NL2031436B1

NL2031436B1 - Hemorrhoid and fistula mixture

Info

Publication number: NL2031436B1
Application number: NL2031436A
Authority: NL
Inventors: Li Zuomin
Original assignee: Li Zuomin
Priority date: 2021-12-20
Filing date: 2022-03-29
Publication date: 2023-06-28
Also published as: CN114699451A

Abstract

The present disclosure provides a hemorrhoid and fistula mixture, belongs to the technical field, of traditional Chinese medicine preparation. The hemorrhoid and fistula mixture comprises an external traditional Chinese medicine composition and an oral traditional Chinese medicine composition. The oral traditional Chinese medicine composition of the invention can treat hemorrhoids through the systematic circulation to the microcirculation, and simultaneously change the patient's constitution, improve the body's Qi, enhance the human body's immune function, and is not easy to relapse after being cured; the external traditional Chinese medicine composition can be absorbed through local microcirculation, and together with the appropriate temperature, can enhance the local microcirculation, clear and purify the local purulent or non—purulent compounds, increase local disease resistance, and quickly eliminate incarcerated lesions, and the symptoms of edema, inflammation and suppuration, quickly relieve the pains, to achieve the immediate therapeutic effect.

Description

HEMORRHOID AND FISTULA MIXTURE

TECHNICAL FIELD

The present disclosure relates to the technical field of tra- ditional Chinese medicine preparation, and particularly relates to a hemorrhoid and fistula mixture.

BACKGROUND ART

Hemorrhoid and fistula is a common and frequently-occurring disease in clinical practice. The main symptoms of hemorrhoid and fistula are blood in the stool, pain, prolapse, increased local secretions and difficulty in defecation, etc. The main causes of the disease are the imbalance of yin and yang in the human body, together with the factors of external wind, heat, dryness and dampness, and internal injuries such as six evils and seven emo- tions. Hemorrhoids can be classified into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids according to their ana- tomical location. The disease is caused by prolonged standing, sedentary or overwork, and is a local venous return disorder. Pa- tients are extremely distressed, restless in severe cases, and af- fect their normal work and life.

The traditional method of treating hemorrhoids is to use western medicines to reduce inflammation or surgical excision and repair. Western medicines are expensive and have toxic and side effects. However, surgical excision cannot cure it, the cost is gradually increased, and the phenomenon of recurrence often oc- curs. Some patients are not suitable for surgery, and even have life-threatening conditions. At present, although there are re- ports of traditional Chinese medicines for the treatment of hemor- rhoids, they are basically single prescriptions, which are oral traditional Chinese medicine compositions or external traditional

Chinese medicine compositions. Side effects are large, and some have a high recurrence rate after use. In addition, their curative effect is different, some medicines have slow effect, short dura- tion of drug effect, some medicines have serious side effects, and some medicines have high recurrence rate after use.

SUMMARY

The present disclosure aims to provide a hemorrhoid and fis- tula mixture. The hemorrhoid and fistula mixture has the effects of being quick in effect, high in cure rate and not prone to re- lapse.

In order to achieve the above purpose, the present disclosure provides the following technical solutions:

The present disclosure provides a hemorrhoid and fistula mix- ture. The hemorrhoid and fistula mixture comprises an external traditional Chinese medicine composition, and the external tradi- tional Chinese medicine composition is prepared from the following components in parts by weight: 50-60 parts of LINDERA GLAUCA (SIEB. ETZUCC.)BL., 70-80 parts of ILICIS CHINENSIS FOLIUM, 40-50 parts of SOPHORAE FLAVESCENTIS RADIX,40-50 parts of CITRI RETICU-

LATAE PERICARPIUM, 40-50 parts of MUME FRUCTUS, 20-30 parts of

RHEI RADIX ET RHIZOMA, 20-30 parts of NATRII SULFAS and 40-50 parts of ARNEBIAE RADIX.

The present disclosure provides a hemorrhoid and fistula mix- ture. The hemorrhoid and fistula mixture further comprises an oral traditional Chinese medicine composition, wherein the oral tradi- tional Chinese medicine composition is prepared from the following components in parts by weight: 40-50 parts of LONICERAE JAPONICAE

FLOS, 50-60 parts of HOUTTUYNIAE HERBA, 20-30 parts of PAEONIAE

RADIX RUBRA, 20-30 parts of PAEONIAE RADIX ALBA, 10-20 parts of

GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE, 30-40 parts of

VIGNAE SEMEN, 60-70 parts of COICIS SEMEN, 20-30 parts of

PLANTAGINIS SEMEN, 40-50 parts of ASTRAGALI RADIX, 90-100 parts of

ILEX PUBESCENS HOOK. ET ARN., 10-20 parts of LYCOPI HERBA, 10-16 parts of HIRUDO, 70-80 parts of FRUCTUS HORDEI GERMINATUS, 60-70 parts of HORDEI FRUCTUS GERMINATUS and 10-20 parts of VESPAE NI-

DUS.

The present disclosure provides a method for preparing a hem- orrhoid and fistula mixture. The preparation method comprises the following steps: crushing all components of an external tradition- al Chinese medicine composition into fine powder with the size of

70-100 meshes, and uniformly mixing to obtain the external tradi- tional Chinese medicine composition.

The present disclosure further provides an application of a hemorrhoid and fistula mixture in preparation of a medicine for treating hemorrhoid and fistula. An application method of the ex- ternal traditional Chinese medicine composition comprises the fol- lowing steps: soaking the external traditional Chinese medicine composition with 2,000-2,500 ml of boiled water for 20-30 min; and after cooled to 40-50°C, carrying out hip bath for 20-30 min, once or twice a day. An application of an oral traditional Chinese med- icine composition comprises the following steps: taking one dose of the oral traditional Chinese medicine composition after mixing with boiled water for 3-4 times for a patient with a body weight more than 75 kg each time; taking one dose of the oral traditional

Chinese medicine composition after mixing with boiled water for 2- 3 times for a patient with a body weight of 50 kg-75 kg each time; and taking one dose of the oral traditional Chinese medicine com- position after mixing with boiled water for once or twice for a patient with a body weight less than 50 kg each time.

Preferably, the dosage of the oral traditional Chinese medi- cine composition is 115-125 g/dose.

Compared with the prior art, the present disclosure has the following beneficial effects: 1, the hemorrhoid and fistula mixture combines local medica- tion and oral administration, and compared with modern hemorrhoid local injection medication or operative treatment, the hemorrhoid and fistula mixture is free of pain and safe. 2, the hemorrhoid and fistula mixture is fast in effect, high in cure rate and not prone to relapse, the relapse rate of modern western medicine local injection and operation is high, and anus can become small. 3, the oral traditional Chinese medicine composition in the hemorrhoid and fistula mixture can comprehensively improve a pa- tient’s physical conditions and improve immunity, can treat hemor- rhoid and fistula, and can improve the symptoms of emphysema, ir- regular menstruation {all Qi deficiency types), fatigue and weak- ened immunity (frequent cold).

5, the hemorrhoid and fistula mixture is low in cost and has wide popularization.

DETAILED DESCRIPTION OF THE EMBODIMENTS

The present disclosure provides a hemorrhoid fistula mixture, which comprises an external Chinese medicine composition and an oral traditional Chinese medicine composition.

In the present disclosure, the external traditional Chinese medicine composition is preferably prepared from the following components in parts by weight: 50-60 parts of LINDERA GLAUCA (SIEB. ETZUCC.)BL., 70-80 parts of ILICIS CHINENSIS FOLIUM, 40-50 parts of SOPHORAE FLAVESCENTIS RADIX, 40-50 parts of CITRI RETICU-

LATAE PERICARPIUM, 40-50 parts of MUME FRUCTUS, 20-30 parts of

RHEI RADIX ET RHIZOMA, 20-30 parts of NATRII SULFAS and 40-50 parts of ARNEBIAE RADIX; more preferably from the following compo- nents in parts by weight: 53-55 parts of LINDERA GLAUCA (SIEB.

ETZUCC. )BL., 73-76 parts of ILICIS CHINENSIS FOLIUM, 44-47 parts of SOPHORAE FLAVESCENTIS RADIX, 44-47 parts of CITRI RETICULATAE

PERICARPIUM, 44-47 parts of MUME FRUCTUS, 24-26 parts of RHEI RA-

DIX ET RHIZOMA, 24-26 parts of NATRII SULFAS and 44-47 parts of

ARNEBIAE RADIX The components of external traditional Chinese med- icine composition provided in the embodiments of the present dis- closure are qualified decoction pieces provided by Jiafang Medi- cine Company in Wanzhou district. The combination of LINDERA GLAU-

CA (SIEB. ETZUCC.)BL., ILICIS CHINENSIS FOLIUM and RHEI RADIX ET

RHIZOMA has the effects of diminishing swelling, dispersing blood stasis and relieving pain; the combination of CITRI RETICULATAE

PERICARPIUM, MUME FRUCTUS and ARNEBIAE RADIX has the effects of astringing, stopping bleeding and preventing corrosion; and the combination of SOPHORAE FLAVESCENTIS RADIX and NATRII SULFAS has the effects of eliminating dampness and diminishing swelling.

The oral traditional Chinese medicine composition is prefera- bly prepared from the following components in parts by weight: 40- 50 parts of LONICERAE JAPONICAE FLOS, 50-60 parts of HOUTTUYNIAE

HERBA, 20-30 parts of PAEONIAE RADIX RUBRA, 20-30 parts of PAEONI-

AE RADIX ALBA, 10-20 parts of GLYCYRRHIZAE RADIX ET RHIZOMA PRAE-

PARATA CUM MELLE, 30-40 parts of VIGNAE SEMEN, 60-70 parts of COI-

CIS SEMEN, 20-30 parts of PLANTAGINIS SEMEN, 40-50 parts of

ASTRAGALI RADIX, 90-100 parts of ILEX PUBESCENS HOOK. ET ARN., 10- 20 parts of LYCOPI HERBA, 10-16 parts of HIRUDO, 70-80 parts of

FRUCTUS HORDEI GERMINATUS, 60-70 parts of HORDEI FRUCTUS GERMINA- 5 TUS and 10-20 parts of VESPAE NIDUS; more preferably prepared from the following components in parts by weight: 44-47 parts of LONIC-

ERAE JAPONICAE FLOS, 54-55 parts of HOUTTUYNIAE HERBA, 23-26 parts of PAEONIAE RADIX RUBRA, 23-26 parts of PAEONIAE RADIX ALBA, 13-16 parts of GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE, 34-36 parts of VIGNAE SEMEN, 64-67 parts of COICIS SEMEN, 13-16 parts of

PLANTAGINIS SEMEN, 44-47 parts of ASTRAGALI RADIX, 94-97 parts of

ILEX PUBESCENS HOOK. ET ARN., 13-16 parts of LYCOPI HERBA, 12-14 parts of HIRUDO, 74-78 parts of FRUCTUS HORDEI GERMINATUS, 64-67 parts of HORDEI FRUCTUS GERMINATUS and 13-16 parts of VESPAE NI-

DUS. The combination of LONICERAE JAPONICAE FLOS, HOUTTUYNIAE

HERBA, PAEONIAE RADIX RUBRA, VIGNAE SEMEN, COICIS SEMEN and

PLANTAGINIS SEMEN has the effects of inducing diuresis, clearing heat and diminishing swelling, controls local inflammation and swelling of hemorrhoid and fistula, and relieves incarceration edema symptoms and causes; the combination of LYCOPI HERBA and

HIRUDO has the effects of dispersing blood stasis and improving blood circulation; CITRI RETICULATAE PERICARPIUM has the effect of regulating Qi; the combination of ILEX PUBESCENS HOOK. ET ARN. and

LYCOPI HERBA has the effects of activating meridians to stop pain and promoting blood circulation; the combination of PAEONIAE RADIX

ALBA and GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE has the effects of relieving various diseases (including smooth muscle spasm); the GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE root also has the effect of preventing allergy of patients; VESPAE

NIDUS has the effects of resisting bacteria and prolonging the drug effects of other drugs; and the combination of ASTRAGALI RA-

DIX, FRUCTUS HORDEI GERMINATUS and HORDEI FRUCTUS GERMINATUS has the effect of improving the immunity and digestive function of pa- tients, and also can enable the patients to have normal diets.

In the embodiments of the present disclosure, the components of the oral traditional Chinese medicine composition are tradi- tional Chinese medicine granules respectively provided by Guang-

dong Yifang Parmaceutical Co., Ltd., the traditional Chinese medi- cine granules are single-ingredient granules prepared by selecting high-quality traditional Chinese medicine decoction pieces with standard processing as raw materials and extracting and concen- trating, the properties and flavor effects of the single- ingredient granules are consistent with those of the original tra- ditional Chinese medicine decoction pieces, and the single- ingredient granules are used for a traditional Chinese medicine clinical formula. According to the oral traditional Chinese medi- cine composition provided by the present disclosure, the single- ingredient granules are uniformly mixed based on the component ra- tio, preferably, the single-ingredient granules are subpackaged according to 115-125 g/dose, and more preferably, the single- ingredient granules are subpackaged according to 119 g/dose.

In the present disclosure, the preparation method of the ex- ternal traditional Chinese medicine composition comprises the fol- lowing steps: crushing all components of an external traditional

Chinese medicine composition into fine powder with the size of 70- 100 meshes, and uniformly mixing, and repeating the crushing and mixing for 2 to 5 times, to obtain the external traditional Chi- nese medicine composition powder. Preferably, traditional Chinese medicine composition powder is subpackaged in sealed bags accord- ing to the proportion of 140-160 g/dose to obtain the external traditional Chinese medicine composition. More preferably, the traditional Chinese medicine composition is subpackaged in sealed bags according to the proportion of 150 g/dose. The hemorrhoid and fistula mixture is directly smashed, is not prepared into a water agent or an ointment, thus protecting and keeping the biological activity of each medicine in the prescription, especially medi- cines with aromatic smell such as RHEI RADIX ET RHIZOMA and ILICIS

CHINENSIS FOLIUM. Each dose of the external traditional Chinese medicine composition is used for hip bath once or twice.

In the present disclosure, an application method of the ex- ternal traditional Chinese medicine composition preferably com- prises the following steps: soaking the external traditional Chi- nese medicine composition with 2,000-2,500 ml of boiled water for 20-30 min; and after cooled to 40-50°C, carrying out hip bath for

20-30 min, one dose per day, once or twice a day. A metal basin or a wooden bidet is preferably adopted for hip bath, and a plastic basin cannot be used. In the present disclosure, a non-woven fab- ric bagged medicinal powder is required to be soaked in water for hip bath for female, and hip bath cannot be performed during men- strual period. In the present disclosure, a bagged Chinese medici- nal composition is required to be equally used when hip bath is performed twice every day.

In the present disclosure, an application of an oral tradi- tional Chinese medicine composition preferably comprises the fol- lowing steps: taking one dose of the oral traditional Chinese med- icine composition after mixing with boiled water for 3-4 times for a patient with a body weight more than 75 kg each time; taking one dose of the oral traditional Chinese medicine composition after mixing with boiled water for 2-3 times for a patient with a body weight of 50 kg-75 kg each time; and taking one dose of the oral traditional Chinese medicine composition after mixing with boiled water for once or twice for a patient with a body weight less than 50 kg each time. The oral traditional Chinese medicine composition of the present disclosure cannot be taken by women during menstru- ation; and those with thrombocytopenia, hemophilia and severe ane- mia are not suitable to take. The oral traditional Chinese medi- cine composition of the present disclosure is preferably 115-125 g per dose, more preferably 119 g per dose.

The technical solution of the present disclosure will be de- scribed clearly and completely below in conjunction with the em- bodiments. Obviously, embodiments described are only a part of em- bodiments of the present disclosure, and are not all of embodi- ments thereof. All other embodiments obtained by persons of ordi- nary skill in the art based on the embodiments of the present dis- closure without creative efforts shall fall within the protection scope of the present disclosure.

Example 1

The external traditional Chinese medicine composition was prepared from the following components in parts by weight: 60 parts of LINDERA GLAUCA (SIEB. ETZUCC.)BL., 80 parts of ILICIS

CHINENSIS FOLIUM, 50 parts of SOPHORAE FLAVESCENTIS RADIX, 50 parts of CITRI RETICULATAE PERICARPIUM, 50 parts of MUME FRUCTUS, 30 parts of RHEI RADIX ET RHIZOMA, 30 parts of NATRII SULFAS and 50 parts of ARNEBIAE RADIX

The oral traditional Chinese medicine composition was pre- pared from the following components in parts by weight: 50 parts of LONICERAE JAPONICAE FLOS, 60 parts of HOUTTUYNIAE HERBA, 30 parts of PAEONIAE RADIX RUBRA, 30 parts of PAEONIAE RADIX ALBA, 20 parts of GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE, 40 parts of VIGNAE SEMEN, 70 parts of COICIS SEMEN, 30 parts of

PLANTAGINIS SEMEN, 50 parts of ASTRAGALI RADIX, 100 parts of ILEX

PUBESCENS HOOK. ET ARN., 20 parts of LYCOPI HERBA, 16 parts of

HIRUDO, 80 parts of FRUCTUS HORDEI GERMINATUS, 70 parts of HORDEI

FRUCTUS GERMINATUS and 20 parts of VESPAE NIDUS.

A preparation method of the external traditional Chinese med- icine composition comprised the following steps: crushing all com- ponents of an external traditional Chinese medicine composition into fine powder with the size of 80 meshes, and uniformly mixing, repeating the crushing and the mixing for 5 times, to obtain the external traditional Chinese medicine composition powder. The tra- ditional Chinese medicine composition powder was subpackaged into sealed bags by 150 g/bag to obtain the external traditional Chi- nese medicine composition.

A preparation method of the oral traditional Chinese medicine composition comprised the following steps: extracting and concen- trating into single-ingredient granules by adopting modern high technology by Guangdong Yifang Pharmaceutical Co., Ltd., and then uniformly mixing the single-ingredient granules according to the weight parts of the components, subpackaging by 119 g/dose, to cb- tain the oral traditional Chinese medicine composition.

Example 2

The external traditional Chinese medicine composition was prepared from the following components in parts by weight: 50 parts of LINDERA GLAUCA (SIEB. ETZUCC.)BL., 70 parts of ILICIS

CHINENSIS FOLIUM, 50 parts of SOPHORAE FLAVESCENTIS RADIX, 50 parts of CITRI RETICULATAE PERICARPIUM, 40 parts of MUME FRUCTUS, 30 parts of RHEI RADIX ET RHIZOMA, 30 parts of NATRII SULFAS and parts of ARNEBIAE RADIX

The oral traditional Chinese medicine composition was pre- pared from the following components in parts by weight: 40 parts of LONICERAE JAPONICAE FLOS, 55 parts of HOUTTUYNIAE HERBA, 20 parts of PAEONIAE RADIX RUBRA, 20 parts of PAEONIAE RADIX ALBA, 10 parts of GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE, 30 parts of VIGNAE SEMEN, 50 parts of COICIS SEMEN, 20 parts of

PLANTAGINIS SEMEN, 40 parts of ASTRAGALI RADIX, 93 parts of ILEX

PUBESCENS HOOK. ET ARN., 10 parts of LYCOPI HERBA, 10 parts of

HIRUDO, 72 parts of FRUCTUS HORDEI GERMINATUS, 63 parts of HORDEI

FRUCTUS GERMINATUS and 13 parts of VESPAE NIDUS.

A preparation method of the external traditional Chinese med- icine composition comprised the following steps: crushing all com- ponents of an external traditional Chinese medicine composition into fine powder with the size of 70 meshes, and uniformly mixing, repeating the crushing and the mixing for 3 times, to obtain the external traditional Chinese medicine composition powder. The tra- ditional Chinese medicine composition powder was subpackaged into sealed bags by 160 g/bag to obtain the external traditional Chi- nese medicine composition.

The preparation method of the oral traditional Chinese medi- cine composition was the same as that in Example 1.

Example 3

CHINENSIS FOLIUM, 40 parts of SOPHORAE FLAVESCENTIS RADIX, 40 parts of CITRI RETICULATAE PERICARPIUM, 50 parts of MUME FRUCTUS, 20 parts of RHEI RADIX ET RHIZOMA, 20 parts of NATRII SULFAS and 50 parts of ARNEBIAE RADIX

PLANTAGINIS SEMEN, 43 parts of ASTRAGALI RADIX, 100 parts of ILEX

PUBESCENS HOOK. ET ARN., 19 parts of LYCOPI HERBA, 13 parts of

HIRUDO, 80 parts of FRUCTUS HORDEI GERMINATUS, 70 parts of HORDET

FRUCTUS GERMINATUS and 20 parts of VESPAE NIDUS.

A preparation method of the external traditional Chinese med- icine composition comprised the following steps: crushing all com- ponents of an external traditional Chinese medicine composition into fine powder with the size of 100 meshes, and uniformly mix- ing, repeating the crushing and the mixing for 4 times, to obtain the external traditional Chinese medicine composition powder. The traditional Chinese medicine composition powder was subpackaged into sealed bags by 150 g/bag to obtain the external traditional

Chinese medicine composition.

The preparation method of the oral traditional Chinese medi- cine composition was the same as that in Example 1 except of the subpackage of 122 g/dose.

Example 4

The external traditional Chinese medicine composition was prepared from the following components in parts by weight: 58 parts of LINDERA GLAUCA (SIEB. ETZUCC.)BL., 74 parts of ILICIS

CHINENSIS FOLIUM, 48 parts of SOPHORAE FLAVESCENTIS RADIX, 46 parts of CITRI RETICULATAE PERICARPIUM, 41 parts of MUME FRUCTUS, 26 parts of RHEI RADIX ET RHIZOMA, 26 parts of NATRII SULFAS and 48 parts of ARNEBIAE RADIX

The oral traditional Chinese medicine composition was pre- pared from the following components in parts by weight: 47parts of

LONICERAE JAPONICAE FLOS, 54parts of HOUTTUYNIAE HERBA, 29 parts of PAEONIAE RADIX RUBRA, 27 parts of PAEONIAE RADIX ALBA, 19 parts of GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE, 37 parts of

VIGNAE SEMEN, 65 parts of COICIS SEMEN, 27 parts of PLANTAGINIS

SEMEN, 45 parts of ASTRAGALI RADIX, 94 parts of ILEX PUBESCENS

HOOK. ET ARN., 16 parts of LYCOPI HERBA, 16 parts of HIRUDO, 75 parts of FRUCTUS HORDEI GERMINATUS, 64 parts of HORDEI FRUCTUS

GERMINATUS and 20 parts of VESPAE NIDUS.

A preparation method of the external traditional Chinese med- icine composition comprised the following steps: crushing all com- ponents of an external traditional Chinese medicine composition into fine powder with the size of 90 meshes, and uniformly mixing, repeating the crushing and the mixing for 4 times, to obtain the external traditional Chinese medicine composition powder. The tra- ditional Chinese medicine composition powder was subpackaged into sealed bags by 140 g/bag to obtain the external traditional Chi- nese medicine composition.

Example 5

The external traditional Chinese medicine composition was prepared from the following components in parts by weight: 55 parts of LINDERA GLAUCA (SIEB. ETZUCC.)BL., 79 parts of ILICIS

CHINENSIS FOLIUM, 43 parts of SOPHORAE FLAVESCENTIS RADIX, 46 parts of CITRI RETICULATAE PERICARPIUM, 42 parts of MUME FRUCTUS, 23 parts of RHEI RADIX ET RHIZOMA, 21 parts of NATRII SULFAS and 41 parts of ARNEBIAE RADIX

The oral traditional Chinese medicine composition was pre- pared from the following components in parts by weight: 50 parts of LONICERAE JAPONICAE FLOS, 60 parts of HOUTTUYNIAE HERBA, 26 parts of PAEONIAE RADIX RUBRA, 26 parts of PAEONIAE RADIX ALBA, 10 parts of GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE, 33 parts of VIGNAE SEMEN, 66 parts of COICIS SEMEN, 22 parts of

PLANTAGINIS SEMEN, 46 parts of ASTRAGALI RADIX, 98 parts of ILEX

PUBESCENS HOOK. ET ARN., 10 parts of LYCOPI HERBA, 10 parts of

HIRUDO, 75 parts of FRUCTUS HORDEI GERMINATUS, 64 parts of HORDEI

FRUCTUS GERMINATUS and 20 parts of VESPAE NIDUS.

A preparation method of the external traditional Chinese med- icine composition comprised the following steps: crushing all com- ponents of an external traditional Chinese medicine composition into fine powder with the size of 80 meshes, and uniformly mixing, repeating the crushing and the mixing for 3 times, to obtain the external traditional Chinese medicine composition powder. The tra- ditional Chinese medicine composition powder was subpackaged into sealed bags by 150 g/bag to obtain the external traditional Chi- nese medicine composition.

The preparation method of the oral traditional Chinese medi- cine composition was the same as that in Example 1 except of the subpackage of 118 g/dose.

Example 6 Clinical observation (1) Clinical data: From the beginning of 2018 to the end of

September 2021, a total of 355 patients were admitted, and the pa- tients were clinically observed and treated. (2) Use method: a use method of an external traditional Chi- nese medicine composition comprised the following steps: soaking the external traditional Chinese medicine composition with 2,000- 2,500 ml of boiled water for 20-30 min, and performing hip bath for 20-30 min when cooled to 40-50 °C, wherein one bag of the ex- ternal traditional Chinese medicine composition was used every day, once or twice a day.

A use method of an oral traditional Chinese medicine composi- tion comprises the following steps: taking one dose of the oral traditional Chinese medicine composition after mixing with boiled water for 3-4 times for a patient with a body weight being greater than 75 kg; taking one dose of the oral traditional Chinese medi- cine composition after mixing with boiled water for 2-3 times for a patient with a body weight being 50-75 kg; and taking one dose of the oral traditional Chinese medicine composition after mixing with boiled water for once or twice for a patient with a body weight being less than 50 kg. (3) Efficacy criteria

Cure: The original symptoms of edema, incarceration, pro- lapse, pain, pus, bleeding and suppuration of the anus disap- peared.

Remarkably effective: Symptoms such as edema, pain, pus, bleeding, suppuration caused by annular mixed hemorrhoids, inter- nal and external hemorrhoids, or mixed hemorrhoids incarcerated basically disappeared or completely disappeared.

Effective: Pain relief, painless walking, smaller hemorrhoids and thrombolysis.

Ineffective: No symptomatic changes. (4) Clinical results

The clinical effective rate was 98%, the cure rate was 90%, and the remarkably effective rate was 75%. So far, no allergic pa- tients have been found.

Typical case 1

Li Moufeng, female, 32 years old, was diagnosed with perianal abscess in the hospital at the beginning of 2019, and was referred to our clinic for treatment. The perianal abscess in the affected area had no symptoms of pus discharge from the external mouth, and there was severe pain on both sides when touching the perianal ar- ea with fingers, the patient was afraid of surgical treatment and was looking for a painless treatment method. The present inventor prescribed a prescription and medication in Example 1 for the pa- tient: external traditional Chinese medicine composition, one dose per day, twice a day, once in the morning and once in the evening; oral traditional Chinese medicine composition, 3 times a day, once every 8 h. After the combined treatment of oral and external Chi- nese medicine compositions, she was completely cured after a week, and there was no pain when touching the affected area, and there has been no recurrence so far.

Typical case 2

Ma xx, male, 45 years old, felt perianal pain in the summer of 2019, was diagnosed with perianal abscess in the hospital, and was referred to our clinic for treatment. The patient provided relevant evidence for examination in the hospital, and communicat- ed with the inventor in detail about the condition through video.

The present inventor prescribed the prescription and medication in

Example 1: 7 doses of external composition, one dose per day for a hip bath; 7 doses of oral traditional Chinese medicine composi- tion, one dose per day, three times a day, and once every 8 hours. 7 doses of the external Chinese medicine composition and 7 doses of the oral Chinese medicine composition were delivered to the pa- tient, and after one week of treatment, he was completely cured, and there has been no recurrence so far.

Typical case 3

Ren xx, male, 45 years old, in June 2018, suffered from peri- anal abscess due to fatigue and could not sit and was referred to our clinic. The inventor prescribed the prescription and medica- tion in Example 1 for the patient: external Chinese medicine com- position for a week, hip bath twice a day, once in the morning and once in the evening, 5 doses of oral traditional Chinese medicine composition, 3 times a day, once every 8 hours. He was cured after a week.

Typical case 4

Yu xx, male, was a student of 24 years old. Ten years ago, the patient returned to Wanzhou for the Spring Festival before graduation. During this period, he developed a perianal abscess.

The patient's constitution was poor. After the surgery in the hos- pital, the abscess did not cure for a long time, and the abscess was dripping. At this time, the patient was unable to go back to school due to the disease, and was very anxious. He was referred to our clinic. Physical examination: the external opening of the anal fistula was orthopedic and cured. The inventor cut off the orthopedic skin with hemorrhoid-eliminating scissors, and then took a hip bath with Chinese herbal decoction, and prescribed med- icine for invigorating Qi and removing blood stasis for oral ad- ministration, which was soon cured. But the disease recurred in the second year due to that the left side suffered from perianal abscess, and now the right side had perianal abscess. The inventor prescribed the prescription in Example 2 for him. It took half a year to finally cure the disease completely, and there has been no recurrence so far.

Typical case 5

Yuan xx, male, 43 years old, was a driver, he suffered from annular mixed hemorrhoids, incarcerated and edema in October 2017.

He was treated by circumcision in the hospital. In theory, the pa- tient should no longer suffer from hemorrhoids. However, after the operation about three months ago, the patient had an unbearable swelling and pain in the anus. He was referred to our clinic.

Physical examination: knee-chest position, anal thrombosis at 3-5 points of the anus, about 1.5 cm in diameter. Treatment plan: 3 doses of external traditional Chinese medicine composition in the

Example 3, each dose was taken by twice, twice a day for hip bath, once in the morning and once in the evening; 3 doses (6 bags) of oral traditional Chinese medicine composition in Example 3, 1 bag each time, twice a day, taking after mixing with boiled water in the morning and evening. On the 4% day, he came to the clinic for re-examination and basically cured, and there has been no recur-

rence so far.

Comparative typical case 1

Zhang xx, male, 70 years old, came to our clinic six years ago to seek medical treatment. He complained that: in recent years, whenever he wanted to defecate, the stool flowed into his crotch if he could not go to the toilet quickly. Physical examina- tion: perianal abscess and surrounding muscle tissues have been surgically removed, the wound was sutured and cured well. The pa- tient underwent surgery in a specialized hospital, and has never had hemorrhoids recur so far. Digital examination with finger cots: no cell mass, pus and blood, anal defect, and sphincter mus- cle relaxation and weakness. For patients cured by this type of operation, the inventors could not remedy the irreversible defects caused by the operation. The hemorrhoid mixture of the present disclosure was easy to cure without any damage, no sequelae, and difficult recurrence, without causing such sequelae.

Comparative typical case 2

Wang xx, male, 45 years old, came to our clinic for an opera- tion to treat anal fissure in the summer of 2016. Consultation: long-term excessive dieting, nutritional deficiencies, body weight loss, anal fissure and habitual constipation symptoms. The inven- tor provided the following treatment plan: treating habitual con- stipation with traditional Chinese medicine decoction first. Anal fissure could be cured slowly by itself. Even if it didn’t cure, surgery could be done after the body got better. The patient did not accept the plan and suggestion of the inventor, and then went to the hospital. After surgical treatment, the anus was bleeding for a long time and did not cure, causing the patient to dare not eat and drink, and his health deteriorated, and he died soon.

The foregoing description merely describes the preferred em- bodiments of the present disclosure. It should be noted that for those of ordinary skill in the art, several improvements and modi- fications can be made without departing from the principle of the present disclosure, and these improvements and modifications shall also fall within the scope of protection of the present disclo- sure.

Claims

CONCLUSIONS

A mixture for the treatment of hemorrhoids and fistulas, comprising an external composition of traditional Chinese medicine, and wherein the external composition of traditional Chinese medicine is prepared from the following components by weight: 50 to 60 parts of LINDERA GLAUCA (SIEB ET-ZUCC.)BL., 70 to 80 parts of ILICIS CHINENSIS FOLIUM, 40 to 50 parts of SOPHORAE FLAVESCENTIS RADIX, 40 to 50 parts of CITRI RETICULATAE PERICARPIUM, 40 to 50 parts of MUME FRUCTUS, 20 to 30 parts of RHEI RADIX ET RHIZOMA, 20 to 30 parts of NATRII SULFAS and 40 to 50 parts of ARNEBIAE RADIX.

The mixture for treatment of hemorrhoids and fistulas according to claim 1, wherein the mixture for treatment of hemorrhoids and fistulas further comprises an oral composition of traditional Chinese medicine, wherein the oral composition of traditional Chinese medicine is prepared from the following ingredients by weight: 40 to 50 parts of LONICERAE JAPONICAE FLOS, 50 to 60 parts of HOUTTUYNIAE HERBA, 20 to 30 parts of PAFEONIAE RADIX RUBRA, 20 to 30 parts of PAEONIAE RADIX ALBA, 10 to 20 parts of GLYCYRRHIZAE RADIX ET RHIZOMA PRAEPARATA CUM MELLE, 30 to 40 parts of VIGNAE SEMEN, 60 to 70 parts of COICIS SEMEN, 20 to 30 parts of PLANTAGINIS SEMEN, 40 to 50 parts of ASTRAGALI RADIX, 90 to 100 parts of ILEX PUBESCENS HOOK. ET ARN., 10 to 20 parts of LYCOPI HERBA, 10 to 16 parts of HIRUDO, 70 to 80 parts of FRUCTUS HORDEI GERMINATUS, 60 to 70 parts of HORDEI FRUCTUS GERMINATUS and 10 to 20 parts of VESPAE NIDUS.

A method for preparing a mixture for the treatment of hemorrhoids and fistulas according to claim 1, comprising the steps of: grinding all components of an external composition of traditional Chinese medicine into fine powder with the size of 70 to 100 mesh, and mixing it uniformly to obtain the external composition according to traditional Chinese medicine.

Use of the mixture for the treatment of hemorrhoids and fistulas according to claim 1 or 2 for preparing a medicament for the treatment of hemorrhoids and fistulas, wherein the application method of the external composition of traditional Chinese medicine is the following steps include: soaking the external composition of traditional Chinese medicine with 2,000 to 2,500 ml of boiled water for 20 to 30 minutes; and after cooling to 40 to 50°C, performing a hip bath for 20 to 30 minutes once or twice a day.

Use of the mixture for the treatment of hemorrhoids and fistulas according to claim 1 or 2 for preparing a medicament for the treatment of hemorrhoids and fistulas, wherein the use of the oral composition of traditional Chinese medicine comprises the following steps include: taking one dose each time of the oral composition of traditional Chinese medicine after mixing with boiled water for 3 to 4 times in case of a patient whose body weight is more than 75 kg; taking one dose each time of the oral composition of traditional Chinese medicine after mixing with boiled water for 2 to 3 times in case of a patient whose body weight is 50 kg to 75 kg; and taking one dose each time of the oral composition of traditional Chinese medicine after mixing with boiled water for one or two times in case of a patient whose body weight is less than 50 kg.

Use according to claim 5, wherein the dosage of the oral composition of traditional Chinese medicine is 115 to 125 g/dose.