CN110585286A - A topical unguent for treating dermatoses, and its preparation method - Google Patents
A topical unguent for treating dermatoses, and its preparation method Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses an external ointment for treating skin diseases, which comprises the following raw materials in parts by weight: 5-20 parts of dandelion, 5-20 parts of honeysuckle, 1-10 parts of mulberry leaves, 0.5-5 parts of mint, 10-30 parts of pseudo-ginseng, 1-10 parts of rose and 0.5-5 parts of folium artemisiae argyi. The invention also provides a preparation method of the external ointment for treating skin diseases. The external ointment provided by the invention is simple in preparation method, and the expected treatment purpose can be achieved by applying the ointment on the affected part.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external ointment for treating skin diseases and a preparation method thereof.
Background
The skin is used as the first physiological defense line and the largest organ of the human body, constantly participates in the functional activities of the body, maintains the unity of opposition between the body and the natural environment, and the abnormal conditions of the body can be reflected on the surface of the skin. The skin has nearly perfect physiological protection function: such as barrier function, sensory function, body temperature regulation, absorption function, secretion and excretion function, etc., and plays an important role in maintaining the health of the body. The physiological function of the skin is impaired, causing skin diseases. Common dermatosis is viral dermatosis: herpes simplex, herpes zoster, wart, chickenpox, rubella, hand-foot-and-mouth disease; bacterial skin diseases: impetigo, folliculitis, furuncle, carbuncle, cellulitis, erysipelas, and leprosy; fungal dermatosis: the medicine has tinea capitis, tinea corporis, tinea cruris, tinea manus, tinea pedis, onychomycosis, pityriasis versicolor and malassezia folliculitis.
At present, the skin disease symptoms such as mosquito bites, urticaria, eczema, miliaria, diaper rash, oral ulcer, dermatitis, dermatophytosis, scabies and the like are most easily caused in life. Most of the existing western medicines and traditional Chinese medicines for treating skin diseases need to be taken by patients for a long time, and in the taking process, the patients are very easy to generate drug resistance, particularly, most of the oral western medicines for treating skin diseases contain hormones, local pigmentation is easy to occur, the disease condition is easy to relapse, and the diseases are lingering and difficult to heal. Therefore, the research of finding the medicine with good treatment effect and low toxic and side effect becomes the key direction of the research in the field, the traditional Chinese medicine has great advantages in treating the diseases, and the aim of treating the root cause is achieved by locally starting with the method of treatment based on syndrome differentiation of traditional Chinese medicines and by clearing heat, detoxifying, dispelling wind and relieving itching.
Disclosure of Invention
In order to solve the defects in the background art, the invention aims to provide an external ointment for treating skin diseases and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention aims to provide an external ointment for treating skin diseases, which comprises the following raw materials in parts by weight: 5-20 parts of dandelion, 5-20 parts of honeysuckle, 1-10 parts of mulberry leaves, 0.5-5 parts of mint, 10-30 parts of pseudo-ginseng, 1-10 parts of rose and 0.5-5 parts of folium artemisiae argyi.
Preferably, the raw materials comprise the following components in parts by weight: 10 parts of dandelion, 10 parts of honeysuckle, 3 parts of mulberry leaf, 1 part of mint, 20 parts of pseudo-ginseng, 5 parts of rose and 3 parts of folium artemisiae argyi.
The second purpose of the invention is to provide a preparation method of the external ointment for treating skin diseases, which comprises the following steps:
s1, weighing 5-20 parts of fresh dandelion, 5-20 parts of honeysuckle, 1-10 parts of mulberry leaves, 0.5-5 parts of mint, 10-30 parts of pseudo-ginseng, 1-10 parts of rose and 0.5-5 parts of folium artemisiae argyi for later use;
s2, mixing the raw material medicines of the S1, juicing, filtering out medicine residues, and filtering out to obtain medicine juice;
s3, heating and concentrating the medicine juice obtained in the step S2 into clear paste, adding the auxiliary agent after the clear paste is cooled, and stirring and mixing the mixture to form thick paste to obtain the ointment.
The pharmacological action and the drug effect of the traditional Chinese medicine of the invention are as follows:
dandelion: bitter and sweet, cold. Clearing away heat and toxic materials, promoting urination, and resolving hard mass; it can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.
And (3) rose: sweet and slightly bitter, slightly warm in nature, entering liver, spleen and stomach meridians; dispersing aromatic substances; has effects in dispersing stagnated liver qi, resolving stagnation, regulating blood flow, and regulating menstruation; it can be used for treating fullness and oppression in chest and diaphragm, distending pain in stomach, hypochondrium, and breast, menoxenia, leucorrhea with red and white discharge, diarrhea, dysentery, traumatic injury, rheumatism, carbuncle, and swelling. Has excellent effects on dry skin, color spots, scars, wounds, burns and scalds, sunburn, eczema and aged skin.
Honeysuckle flower: is cold in nature and sweet in taste, enters lung, heart and stomach meridians, has the effects of clearing away heat and toxic materials, resisting inflammation, tonifying deficiency and treating wind, and is mainly used for treating diseases such as distending pain, fever due to epidemic febrile disease, toxic heat, carbuncle and ulcer, tumor and the like. It has therapeutic effects on dizziness, thirst, hyperhidrosis, vexation, enteritis, bacillary dysentery, measles, pneumonia, encephalitis B, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle, furuncle, erysipelas, parotitis, and suppurative tonsillitis.
Mulberry leaf: is cold in nature, sweet and bitter in taste, has effects of dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver fire, and improving eyesight, and can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight. The mulberry leaves also have good skin beautifying effect, and especially have better curative effect on acne and brown spots on the face.
Mint: pungent taste and cool nature. Disperse wind-heat, clear heat and improve eyesight, relieve sore throat and promote eruption, sooth liver and move qi. It can be used for treating wind-heat type common cold or warm disease, with the symptoms of wind-heat type common cold, headache, sore throat, food stagnation, flatulence, aphtha, toothache, scabies, urticaria, warm disease, rubella pruritus, stagnation of qi due to depression of the liver, chest distress, hypochondriac pain, and flos Lonicerae.
Pseudo-ginseng: warm in nature and pungent in flavor, has remarkable effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, and has the reputations of Jinbuhuan and Nanguo Shencao. Because it is usually a plant of the genus Panax and its active substances are higher and more than that of Panax, it is also called "king of Ginseng" by modern Chinese materia medica pharmacologist. The Qing dynasty pharmaceutical book 'Ben Cao gang mu Shi Yi' records: ginseng, radix Ginseng and Notoginseng are the most precious of the Chinese herbs, because it tonifies qi the first, and it tonifies blood the first, and its flavor is the same and the same. Chinese patent medicines of Yunnan Baiyao and Pianzaihuang of Yangjiangzhong are prepared by using pseudo-ginseng as a main raw material. It can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain.
Folium artemisiae argyi: pungent, bitter and warm; entering liver, spleen and kidney meridians; warming channels to stop bleeding, dispelling cold and relieving pain; it can be used for external application for eliminating dampness, relieving itching and relieving skin pruritus.
Compared with the prior art, the invention has the beneficial effects that:
1) the external ointment for treating skin diseases provided by the invention takes dandelion and honeysuckle as monarch drugs, has the effects of clearing away heat and toxic materials, dispelling wind and arresting itching, and removing necrotic tissue and promoting granulation; mint and pseudo-ginseng are used as ministerial drugs, so that the effects of promoting blood circulation to remove blood stasis, and relieving swelling and pain are achieved; the rose, the mulberry leaves and the folium artemisiae argyi are used as adjuvant drugs, cold dispelling, pain relieving, dampness eliminating and itching relieving effects are achieved, the raw materials are selected and matched accurately, the pathogenesis of skin diseases is hit, heat and toxic materials are removed, wind dispelling and itching relieving effects are achieved, and the traditional Chinese medicine composition is suitable for skin disease patients suffering from mosquito bites, urticaria, eczema, miliaria, diaper rash, oral ulcer, dermatitis, dermatophytosis, scabies and the like, and can achieve a good treatment effect.
2) The external ointment provided by the invention can dispel wind and heat, clear heat and dry dampness, relieve swelling and detoxify, remove necrotic tissue and promote granulation; is especially suitable for patients with mosquito bite, urticaria, eczema, miliaria, diaper rash, oral ulcer, dermatitis, etc.
3) The external ointment provided by the invention is a traditional Chinese medicine preparation, does not generate drug dependence and has no toxic or side effect, and the plaster prepared by the preparation method keeps the medicinal effects of all medicinal materials to the maximum extent.
Detailed Description
In order to make the technical solutions of the present invention better understood and enable those skilled in the art to practice the present invention, the following embodiments are further described, but the present invention is not limited to the following embodiments.
Example 1
An external ointment for treating skin diseases comprises the following raw materials in parts by weight: 10g of dandelion, 10g of honeysuckle, 3g of mulberry leaf, 1g of mint, 20g of pseudo-ginseng, 5g of rose and 3g of folium artemisiae argyi.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
s1, weighing 10g of fresh dandelion, 10g of honeysuckle, 3g of mulberry leaves, 1g of mint, 20g of pseudo-ginseng, 5g of rose and 3g of folium artemisiae argyi according to parts by weight for later use;
s2, mixing the raw material medicines of the S1, juicing, filtering out medicine residues, and filtering out to obtain medicine juice;
s3, heating and concentrating the medicine juice obtained in the step S2 into clear paste, adding auxiliary agents including 10g of castor oil, 5g of ground borneol and 0.5g of ethylparaben after the clear paste is cooled, and stirring and mixing the materials into thick paste to obtain the ointment.
Example 2
An external ointment for treating skin diseases comprises the following raw materials in parts by weight: 5g of dandelion, 5g of honeysuckle, 1g of mulberry leaf, 0.5g of mint, 10g of pseudo-ginseng, 1g of rose and 0.5g of folium artemisiae argyi.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
s1, weighing 5g of fresh dandelion, 5g of honeysuckle, 1g of mulberry leaf, 0.5g of mint, 10g of pseudo-ginseng, 1g of rose and 0.5g of folium artemisiae argyi according to parts by weight for later use;
s2, mixing the raw material medicines of the S1, juicing, filtering out medicine residues, and filtering out to obtain medicine juice;
s3, heating and concentrating the medicine juice obtained in the step S2 into clear paste, adding auxiliary agents including 8g of castor oil, 3g of ground borneol and 0.2g of ethylparaben after the clear paste is cooled, and stirring and mixing the materials into thick paste to obtain the ointment.
Example 3
An external ointment for treating skin diseases comprises the following raw materials in parts by weight: 20g of dandelion, 20g of honeysuckle, 10g of mulberry leaf, 5g of mint, 30g of pseudo-ginseng, 10g of rose and 5g of folium artemisiae argyi.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
s1, weighing 20g of fresh dandelion, 20g of honeysuckle, 10g of mulberry leaves, 5g of mint, 30g of pseudo-ginseng, 10g of rose and 5g of folium artemisiae argyi according to parts by weight for later use;
s2, mixing the raw material medicines of the S1, juicing, filtering out medicine residues, and filtering out to obtain medicine juice;
s3, heating and concentrating the medicine juice obtained in the step S2 into clear paste, adding auxiliary agents including 15g of castor oil, 6g of ground borneol and 0.8g of ethylparaben after the clear paste is cooled, and stirring and mixing the materials into thick paste to obtain the ointment.
The external ointment for treating skin diseases provided in examples 1 to 3, and the therapeutic effects of the external ointment provided in examples 1 to 3 are substantially parallel, the effects of the present invention will be described below by using only the ointment prepared in example 1 as an example.
The effects of the present invention will be further described below using clinical tests.
Clinical trial
1. Clinical data
The outpatient clinic treatment of skin disease patients is 200 cases from 2019. Wherein 100 cases of men and 100 cases of women are aged newborn to 65 years old; 60 cases of mosquito bites, 55 cases of eczema patients, 30 cases of urticaria, 15 cases of miliaria, 10 cases of diaper rash, 9 cases of oral ulcers, 11 cases of dermatophytosis, 7 cases of scabies and 3 cases of dermatitis.
2. Method of treatment
2.1 case grouping
Intervention studies were performed by randomly dividing 200 patients with skin disease into treatment groups and control groups according to the random number table method.
Treatment groups: 100 patients with dermatosis, 50 cases of each of male and female;
control group: 100 patients with skin disease, 50 of them are male and female.
2.2 methods of treatment
Treatment groups: the external ointment prepared in the embodiment 1 of the invention is applied to the affected part for 1 to 3 times per day, and 30 days are 1 course of treatment.
Control group: the ointment is applied to the affected part 1-3 times per day for 30 days and 1 course.
3. Criteria for determining the efficacy of a disease
And (3) healing: the patient's condition was eliminated without recurrence;
the effect is shown: elimination of the patient's condition;
the method has the following advantages: the symptoms of the patients are improved and not completely eliminated, and the patients need to continue taking the medicine;
and (4) invalidation: the symptoms of the patients are not obviously improved.
4. The results of the clinical trials are shown in table 1.
TABLE 1 results of clinical trials
As can be seen from Table 1, the clinical cure rate, the significant efficiency and the total effective rate of two groups of patients are compared, and P is less than 0.05, and the significant difference exists, the clinical test result of the external ointment provided by the embodiment 1 of the invention shows that the total effective rate is up to 98%, the clinical cure rate is 42%, the total effective rate of the control group is 82%, and the significant efficiency is 26%, so that the external ointment for treating the skin disease patients is better than the treatment method of the conventional Chinese patent medicine.
It should be noted that when the following claims refer to numerical ranges, it should be understood that both ends of each numerical range and any value between the two ends can be selected, and since the steps and methods used are the same as those of the embodiments, the preferred embodiments of the present invention have been described for the sake of avoiding redundancy, and although the preferred embodiments of the present invention have been described, those skilled in the art may make other changes and modifications to the embodiments once they learn the basic inventive concept. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (3)
1. The external ointment for treating the skin diseases is characterized by comprising the following raw materials in parts by weight: 5-20 parts of dandelion, 5-20 parts of honeysuckle, 1-10 parts of mulberry leaves, 0.5-5 parts of mint, 10-30 parts of pseudo-ginseng, 1-10 parts of rose and 0.5-5 parts of folium artemisiae argyi.
2. The external ointment for treating skin diseases according to claim 1, characterized in that the raw materials thereof comprise the following components in parts by weight: 10 parts of dandelion, 10 parts of honeysuckle, 3 parts of mulberry leaf, 1 part of mint, 20 parts of pseudo-ginseng, 5 parts of rose and 3 parts of folium artemisiae argyi.
3. A method for preparing an ointment for external use for treating skin diseases according to claim 1, comprising the steps of:
s1, weighing 5-20 parts of dandelion, 5-20 parts of honeysuckle, 1-10 parts of mulberry leaves, 0.5-5 parts of mint, 10-30 parts of pseudo-ginseng, 1-10 parts of rose and 0.5-5 parts of folium artemisiae argyi for later use;
s2, mixing the raw material medicines of the S1, juicing, filtering out medicine residues, and filtering out to obtain medicine juice;
s3, heating and concentrating the medicine juice obtained in the step S2 into clear paste, adding the auxiliary agent after the clear paste is cooled, and stirring and mixing the mixture to form thick paste to obtain the ointment.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111110762A (en) * | 2020-03-05 | 2020-05-08 | 吴丽娜 | Traditional Chinese medicine preparation for treating tinea pedis |
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2019
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Non-Patent Citations (2)
Title |
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余瀛鳌等: "《一味药增颜值》", 31 January 2017, 中国中医药出版社 * |
罗和古等: "《经方验方巧治皮肤病 上册》", 31 August 2007, 中国医药科技出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111110762A (en) * | 2020-03-05 | 2020-05-08 | 吴丽娜 | Traditional Chinese medicine preparation for treating tinea pedis |
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Application publication date: 20191220 |