CN103223132B - Medicine for treating allergic dermatitis and preparation method thereof - Google Patents
Medicine for treating allergic dermatitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicine for treating allergic dermatitis, which comprises raw material medicines and auxiliary materials, wherein the raw material medicines include 5-9 parts of cortex dictamni, 3-7 parts of cavalerie mosla herb, 1-3 parts of fructus kochiae, 1-5 parts of typhonium giganteum, 8-12 parts of radix sophorae flavescentis, 3-7 parts of rhizoma atractylodis, 2-6 parts of rhizoma paridis, 1-5 parts of panax pseudoginseng, 2-6 parts of pricklyash peel, 3-7 parts of liquorice, 1-3 parts of borneol, 3-7 parts of radix stemonae, 4-8 parts of cortex phellodendri and 6-10 parts of fructus cnidii by weight; and the auxiliary materials include 4-8 parts of potassium hydroxide, 5-9 parts of triethanolamine, 4-8 parts of stearyl alcohol, 1-3 parts of chlorhexidine acetate and 3-7 parts of dexamethasone by weight. Based on the principle combining traditional Chinese and western medicine, the medicine provided by the invention has functions of dispelling wind, arresting itching, clearing heat and removing dampness, contains a little hormone, and realizes quick itching arresting without causing dependence; according to clinical tests, the curative effect is obvious, the average effective rate reaches 95.34%, and the allergic dermatitis does not recur easily; and when in use, the medicine is spread on the wound, is convenient to use and does not avoid certain food.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be applicable to treat allergic dermatitis, specifically, relate to a kind of medicine and preparation method for the treatment of allergic dermatitis, belong to tcm field.
Background technology
Skin allergy is a kind of allergy of body, the one abnormal reaction of people to koinomatter (anaphylactogen), just can there is allergy in the crowd who touches allergic constitution when anaphylactogen, anaphylactogen has the hundreds of kinds such as pollen, dust, foreign protein, chemical substance, ultraviolet.In anaphylactoid generating process, Anaphylactic mediator plays direct effect, and anaphylactogen is the exopathogenic factor that irritated disease occurs, and machine immunocompetence is low, and the Oxidative demage of a large amount of radical pair mastocytes and basophil is the irritated endogenous cause of ill occurring.
Skin allergy is a kind of very common irritated form, has 20% people to have skin allergy phenomenon.Skin allergy is called again allergic skin.One large feature of allergic skin is itched exactly.Say from medical angle that skin allergy mainly refers to and be subject to various stimulations as air of the cosmetics of untoward reaction, chemicals, pollen, some food, pollution etc. when skin, cause skin occur red and swollen, itch, the skin allergy symptom such as decortication and allergic dermatitis.
Allergic dermatitis is the dermatosis being caused by anaphylactogen, mainly refer to human body to touch some anaphylactogen and cause red swelling of the skin, itch, the skin disorder such as welt, decortication, be a large class disease in dermatosis, symptom can have redness, itches, bitterly, especially obvious with pruritus.At present, the drug main for the treatment of allergic dermatitis will comprise oral western medicine, external Western medicine ointment and external application Chinese medicine ointment, and oral western medicine can not be eradicated on the one hand, and side effect is large on the other hand; External Western medicine ointment instant effect, but contain hormones, dependency is strong, and drug withdrawal is easily recurred; External application Chinese medicine ointment curative effect is not remarkable, takes effect slow.
Summary of the invention
The technical problem to be solved in the present invention is for above deficiency, and a kind of medicine for the treatment of allergic dermatitis is provided, and has overcome the poor defect of therapeutic effect in prior art, adopts after medicine of the present invention, has advantages of good, the effective fast and difficult recurrence of therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of medicine for the treatment of allergic dermatitis, is characterized in that: described medicine comprises crude drug and adjuvant;
Described crude drug and weight part ratio are: 6～10 parts of 5～9 parts of Cortex Dictamni, 3～7 parts of Herba Moslae Cavalerieis, 1～3 part of the Fructus Kochiae, 1～5 part of Herba Typhonii gigantei, 8～12 parts of Radix Sophorae Flavescentiss, 3～7 parts of Rhizoma Atractylodis, 2～6 parts of Rhizoma Paridis, 1～5 part of Radix Notoginseng, 2～6 parts, Pericarpium Zanthoxyli, 3～7 parts, Radix Glycyrrhizae, 1～3 part of Borneolum Syntheticum, 3～7 parts of the Radixs Stemonae, 4～8 parts of Cortex Phellodendris and Fructus Cnidiis;
Described adjuvant and weight part ratio are: 3～7 parts of 4～8 parts of potassium hydroxide, 5～9 parts of triethanolamine, 4～8 parts of stearyl alcohols, 1～3 part of chlorhexidine acetate and dexamethasone.
A kind of concrete prioritization scheme, described crude drug and weight part ratio are: 8 parts of 7 parts of Cortex Dictamni, 5 parts of Herba Moslae Cavalerieis, 2 parts of the Fructus Kochiae, 3 parts of Herba Typhonii gigantei, 10 parts of Radix Sophorae Flavescentiss, 5 parts of Rhizoma Atractylodis, 4 parts of Rhizoma Paridis, 3 parts of Radix Notoginseng, 4 parts, Pericarpium Zanthoxyli, 5 parts, Radix Glycyrrhizae, 2 parts of Borneolum Syntheticums, 5 parts of the Radixs Stemonae, 6 parts of Cortex Phellodendris and Fructus Cnidiis;
Described adjuvant and weight part ratio are: 5 parts of 6 parts of potassium hydroxide, 7 parts of triethanolamine, 6 parts of stearyl alcohols, 2 parts of chlorhexidine acetate and dexamethasone.
Based on above medicine, the present invention provides again a kind of preparation method of described medicine, it is characterized in that: described preparation method comprises the following steps: the face of 1) described crude drug being dried respectively, pulverized, then take by weight each crude drug mix homogeneously, for subsequent use;
2) by described adjuvant according to weight part ratio mix homogeneously, for subsequent use;
3) by step 1) and step 2) in crude drug and adjuvant be placed in container, fully stir, leave standstill 24～48 hours intermediate;
4) by adding purified water in the intermediate obtaining in step 3), stir into pasty state.
In above raw material:
Cortex Dictamni bitter in the mouth, salty, cold, returns spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel, has the effect of heat clearing and damp drying, dispelling wind for relieving itching, removing toxic substances.Cure mainly rubella, eczema, scabies, jaundice, damp-heat arthralgia due to wind heat noxious dampness.
Herba Moslae Cavaleriei acrid in the mouth, warm in nature, nontoxic, the long-pending loose gas pain relieving of dispeling the wind for oral administration, externally used detumescence pain relieving.Cure mainly traumatic injury, sprain, the long-pending wound of breast abdomen, two sides of body injure, external treatment stiffness along the spinal column pain, radical cure rheumatism convulsion pain, lumbar strain.
The Fructus Kochiae is cold in nature, and acrid in the mouth, hardship enter kidney, urinary bladder channel, have the effect of clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Herba Typhonii gigantei acrid in the mouth, sweet, warm in nature, poisonous, return stomach, Liver Channel, there is drying dampness to eliminate phlegm, expelling wind and relieving convulsion, the function of detoxicating and resolving stagnation of pathogens pain relieving.Eye oblique, middle wind-phlegm heap soil or fertilizer over and around the roots in air port in curing mainly due to wind-phlegm, hemiplegia, tetanus, headache, rheumatic arthralgia, numb limbs and tense tendons, scrofula tuberculosis, carbuncle of yin nature toxic swelling are peppery, venom, infantile convulsion epilepsy, swollen ulcer drug.
Radix Sophorae Flavescentis bitter in the mouth, cold in nature, return liver, kidney, large intestine, small intestine meridian, heart channel, urinary bladder channel, there is the effect of heat clearing and damp drying, wind dispelling insecticide.Cure mainly damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection.
Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel, there is the function of drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Main the spleen and stomach being stranded by dampness, asthenia drowsiness, born of the same parents' painful abdominal mass abdominal distention, inappetence, tells and has loose bowels, phlegm retention, damp-edema, exterior syndrome folder is wet, a heavy sensation of the body pain, arthromyodynia warm nature, podomere is ached and is being weighed ， flaccidity of feet with lamenness.
Rhizoma Paridis bitter in the mouth, is slightly cold, slightly poisonous, returns Liver Channel, has the function of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the arresting convulsion of cool liver.For furuncle carbuncle, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, convulsion with spasms.
Radix Notoginseng sweet in the mouth, micro-hardship, warm in nature, return Liver Channel, stomach warp, heart channel, lung meridian, large intestine channel, there is the function of hemostasis, loose blood, analgesic therapy.Cure mainly to fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen, blood stasis amenorrhea, dysmenorrhea, the cloudy stomachache of the stasis of blood in puerperal, sore, carbuncle and painful swelling.
Pericarpium Zanthoxyli acrid in the mouth, warm in nature, slightly poisonous, return spleen, stomach, kidney channel, there is the function of warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.
Radix Glycyrrhizae sweet in the mouth, property is flat, nontoxic, enters spleen, stomach, lung meridian, has the function of QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Cure mainly asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Borneolum Syntheticum acrid in the mouth, hardship, cool in nature, enter the heart, lung meridian, delicate fragrance a surname is loose, has the function of the refreshment of having one's ideas straightened out, the loose poison of heat clearing away, improving acuity of vision and removing nebula.Cure mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, heat-damp in summer is hoodwinked key clearly, sore throat deafness, aphtha tooth is swollen, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium.
Radix Stemonae sweet in the mouth, hardship, slightly warm in nature, returns lung meridian, has the function of nourishing the lung to arrest cough, parasite killing delousing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, pudendum Pruritus; Honey Radix Stemonae nourishing the lung to arrest cough, for deficiency of YIN chronic cough.
Cortex Phellodendri bitter in the mouth, cold in nature, return kidney, bladder, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, function except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire, for hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Fructus Cnidii acrid in the mouth, hardship, warm in nature, slightly poisonous, return kidney channel, the function of there is removing toxic substances, parasite killing, dampness, dispeling the wind.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
In above adjuvant:
Potassium hydroxide, white oblique square crystal, industrial goods are white or ash gray bulk or bar-shaped, soluble in water, are dissolved in ethanol, are slightly soluble in ether, as emulsifying agent.
Triethanolamine, is water white transparency thick liquid under room temperature, has hygroscopicity and ammonia smelly, is alkalescence, irritant.Mixed water-soluble, ethanol and acetone, be slightly soluble in ether, benzene and carbon tetrachloride, as emulsifying agent.
Stearyl alcohol, wax-like white lobule crystal, savory, water insoluble, be dissolved in ethanol, ether, benzene, chloroform, as pharmaceutic adjuvant, emulsifiable paste matrix.
Chlorhexidine acetate, white crystalline powder, is dissolved in ethanol, has the function of sterilization, can suppress most of gram negative bacteria and gram positive bacteria.
Dexamethasone, Aeroseb-Dex, there is antiinflammatory, antiallergic, rheumatism, immunosuppressive action, be mainly used in treating immunological rejection, oncotherapy and the eye inflammation to glucocorticoid sensitivity etc. of severe bacterial infections and severe allergy disease, various thrombocytopenic purpura, granulocytopenia, serious dermatosis, organ transplantation.
The present invention adopts after above technical scheme, compared with prior art, have the following advantages: described medicine adopts the principle of the combination of Chinese and Western medicine, the each composition of crude drug fully mixes with adjuvant medicine after being pulverized and mixed evenly again, leave standstill, crude drug fully expands, between crude drug and the each composition of adjuvant medicine, interact, there is dispelling wind for relieving itching, effect of removing damp-heat, thereby possesses antiinflammatory, antiallergic, itching-relieving efficacies, and contain a small amount of hormone, antipruriticly be unlikely to again to produce soon dependency, through clinical trial, therapeutic effect is obvious, average effectiveness level reaches 95.34%, and be difficult for recurrence, when use, be applied in affected part, easy to use, without dieting.
Below in conjunction with embodiment, the present invention is described in detail.
The specific embodiment
Embodiment 1, a kind of medicine for the treatment of allergic dermatitis, comprise crude drug and adjuvant, crude drug and weight part ratio are: 8 parts of 7 parts of Cortex Dictamni, 5 parts of Herba Moslae Cavalerieis, 2 parts of the Fructus Kochiae, 3 parts of Herba Typhonii gigantei, 10 parts of Radix Sophorae Flavescentiss, 5 parts of Rhizoma Atractylodis, 4 parts of Rhizoma Paridis, 3 parts of Radix Notoginseng, 4 parts, Pericarpium Zanthoxyli, 5 parts, Radix Glycyrrhizae, 2 parts of Borneolum Syntheticums, 5 parts of the Radixs Stemonae, 6 parts of Cortex Phellodendris and Fructus Cnidiis;
Adjuvant and weight part ratio are: 5 parts of 6 parts of potassium hydroxide, 7 parts of triethanolamine, 6 parts of stearyl alcohols, 2 parts of chlorhexidine acetate and dexamethasone.
Embodiment 2, a kind of medicine for the treatment of allergic dermatitis, comprise crude drug and adjuvant, crude drug and weight part ratio are: 10 parts of 5 parts of Cortex Dictamni, 7 parts of Herba Moslae Cavalerieis, 1 part of the Fructus Kochiae, 2 parts of Herba Typhonii gigantei, 9 parts of Radix Sophorae Flavescentiss, 3 parts of Rhizoma Atractylodis, 7 parts of Rhizoma Paridis, 5 parts of Radix Notoginseng, 3 parts, Pericarpium Zanthoxyli, 6 parts, Radix Glycyrrhizae, 3 parts of Borneolum Syntheticums, 4 parts of the Radixs Stemonae, 4 parts of Cortex Phellodendris and Fructus Cnidiis;
Adjuvant and weight part ratio are: 4 parts of 4 parts of potassium hydroxide, 9 parts of triethanolamine, 7 parts of stearyl alcohols, 1 part of chlorhexidine acetate and dexamethasone.
Embodiment 3, a kind of medicine for the treatment of allergic dermatitis, comprise crude drug and adjuvant, crude drug and weight part ratio are: 9 parts of 6 parts of Cortex Dictamni, 6 parts of Herba Moslae Cavalerieis, 3 parts of the Fructus Kochiae, 1 part of Herba Typhonii gigantei, 8 parts of Radix Sophorae Flavescentiss, 4 parts of Rhizoma Atractylodis, 5 parts of Rhizoma Paridis, 4 parts of Radix Notoginseng, 6 parts, Pericarpium Zanthoxyli, 7 parts, Radix Glycyrrhizae, 1 part of Borneolum Syntheticum, 3 parts of the Radixs Stemonae, 5 parts of Cortex Phellodendris and Fructus Cnidiis;
Adjuvant and weight part ratio are: 3 parts of 5 parts of potassium hydroxide, 8 parts of triethanolamine, 8 parts of stearyl alcohols, 1 part of chlorhexidine acetate and dexamethasone.
Embodiment 4, a kind of medicine for the treatment of allergic dermatitis, comprise crude drug and adjuvant, crude drug and weight part ratio are: 6 parts of 8 parts of Cortex Dictamni, 4 parts of Herba Moslae Cavalerieis, 1 part of the Fructus Kochiae, 5 parts of Herba Typhonii gigantei, 12 parts of Radix Sophorae Flavescentiss, 6 parts of Rhizoma Atractylodis, 6 parts of Rhizoma Paridis, 2 parts of Radix Notoginseng, 5 parts, Pericarpium Zanthoxyli, 3 parts, Radix Glycyrrhizae, 3 parts of Borneolum Syntheticums, 7 parts of the Radixs Stemonae, 8 parts of Cortex Phellodendris and Fructus Cnidiis;
Adjuvant and weight part ratio are: 6 parts of 7 parts of potassium hydroxide, 6 parts of triethanolamine, 5 parts of stearyl alcohols, 3 parts of chlorhexidine acetate and dexamethasone.
Embodiment 5, a kind of medicine for the treatment of allergic dermatitis, comprise crude drug and adjuvant, crude drug and weight part ratio are: 7 parts of 9 parts of Cortex Dictamni, 3 parts of Herba Moslae Cavalerieis, 3 parts of the Fructus Kochiae, 4 parts of Herba Typhonii gigantei, 11 parts of Radix Sophorae Flavescentiss, 7 parts of Rhizoma Atractylodis, 3 parts of Rhizoma Paridis, 1 part of Radix Notoginseng, 7 parts, Pericarpium Zanthoxyli, 4 parts, Radix Glycyrrhizae, 1 part of Borneolum Syntheticum, 6 parts of the Radixs Stemonae, 7 parts of Cortex Phellodendris and Fructus Cnidiis;
Adjuvant and weight part ratio are: 7 parts of 8 parts of potassium hydroxide, 5 parts of triethanolamine, 4 parts of stearyl alcohols, 3 parts of chlorhexidine acetate and dexamethasone.
The medicine of above five embodiment is prepared according to following steps respectively:
1) described crude drug is dried respectively, pulverized face, then takes each crude drug mix homogeneously by weight, for subsequent use;
2) by described adjuvant according to weight part ratio mix homogeneously, for subsequent use;
3) by step 1) and step 2) in crude drug and adjuvant be placed in container, fully stir, leave standstill 24～48 hours intermediate;
4) will in the intermediate obtaining in step 3), add purified water, stir into pasty state and obtain the medicine of described treatment allergic dermatitis;
5) subpackage.
Above steps must operate under aseptic condition.
Using method: external, be applied in affected part, every day 1～3 time, within 5 days, be a course for the treatment of, without dieting.
Points for attention: anemia of pregnant woman, baby, dermatorrhagia person's forbidding.
Above five embodiment gained medicines are used for the treatment of to the test of skin allergy, use efficacy assessment standard to be:
Recovery from illness: gargalesthesia disappears, skin lesion depigmentation calmness all disappears outward or only leaves part and do not purify crust, and drug withdrawal above former affected part later six months is without recurrence;
Effective: gargalesthesia obviously alleviates, skin lesion disappears more than 80%, but does not eliminate completely;
Invalid: gargalesthesia is unchanged or increase the weight of, skin lesion disappears unchanged.
Contrast test: choose 180 routine allergic dermatitis patients, be divided at random 5 test group and a matched group, every group of 30 people of test group, matched group 30 people, test group 1 is used the Drug therapy of embodiment 1 gained, test group 2 is used the Drug therapy of embodiment 2 gained, test group 3 is used the Drug therapy of embodiment 3 gained, test group 4 is used the Drug therapy of embodiment 4 gained, test group 5 is used the Drug therapy of the embodiment of the present invention 5 gained, if 30 examples are matched group, matched group adopts chlorpheniramine maleate tablets and dexamethasone to treat, and total effective rate is 73.3%.
The result that obtains of test is as following table:
As can be seen from the above data, the Drug therapy skin allergy that uses five embodiment of the present invention to prepare, the effective percentage of medicine prepared by five embodiment of the present invention is all high than the effective percentage of matched group conventional therapy, and average effectiveness level reaches 95.34%, and wherein the effect of embodiment 1 is best.
The above is giving an example of best mode for carrying out the invention, and the part of wherein not addressing is in detail those of ordinary skills' common practise.Protection scope of the present invention is as the criterion with the content of claim, and any equivalent substitution carrying out based on technology enlightenment of the present invention, also within protection scope of the present invention.
Claims (3)
1. a medicine for the treatment of allergic dermatitis, is characterized in that: described medicine is made up of crude drug and adjuvant;
Described crude drug and weight part ratio are: 6～10 parts of 5～9 parts of Cortex Dictamni, 3～7 parts of Herba Moslae Cavalerieis, 1～3 part of the Fructus Kochiae, 1～5 part of Herba Typhonii gigantei, 8～12 parts of Radix Sophorae Flavescentiss, 3～7 parts of Rhizoma Atractylodis, 2～6 parts of Rhizoma Paridis, 1～5 part of Radix Notoginseng, 2～6 parts, Pericarpium Zanthoxyli, 3～7 parts, Radix Glycyrrhizae, 1～3 part of Borneolum Syntheticum, 3～7 parts of the Radixs Stemonae, 4～8 parts of Cortex Phellodendris and Fructus Cnidiis;
Described adjuvant and weight part ratio are: 3～7 parts of 4～8 parts of potassium hydroxide, 5～9 parts of triethanolamine, 4～8 parts of stearyl alcohols, 1～3 part of chlorhexidine acetate and dexamethasone.
2. a kind of medicine for the treatment of allergic dermatitis as claimed in claim 1, is characterized in that: described crude drug and weight part ratio are: 8 parts of 7 parts of Cortex Dictamni, 5 parts of Herba Moslae Cavalerieis, 2 parts of the Fructus Kochiae, 3 parts of Herba Typhonii gigantei, 10 parts of Radix Sophorae Flavescentiss, 5 parts of Rhizoma Atractylodis, 4 parts of Rhizoma Paridis, 3 parts of Radix Notoginseng, 4 parts, Pericarpium Zanthoxyli, 5 parts, Radix Glycyrrhizae, 2 parts of Borneolum Syntheticums, 5 parts of the Radixs Stemonae, 6 parts of Cortex Phellodendris and Fructus Cnidiis;
Described adjuvant and weight part ratio are: 5 parts of 6 parts of potassium hydroxide, 7 parts of triethanolamine, 6 parts of stearyl alcohols, 2 parts of chlorhexidine acetate and dexamethasone.
3. the preparation method of a kind of medicine for the treatment of allergic dermatitis as claimed in claim 1 or 2, is characterized in that: described preparation method comprises the following steps:
1) described crude drug is dried respectively, pulverized face, then takes each crude drug mix homogeneously by weight, for subsequent use;
2) by described adjuvant according to weight part ratio mix homogeneously, for subsequent use;
3) by step 1) and step 2) in crude drug and adjuvant be placed in container, fully stir, leave standstill 24～48 hours intermediate;
4) by adding purified water in the intermediate obtaining in step 3), stir into pasty state.
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| CN103976921B (en) * | 2014-05-31 | 2016-08-31 | 广州丹奇日用化工厂有限公司 | A kind of Herba Moslae Cavaleriei extracting solution and its preparation method and application |
| US20190054007A1 (en) * | 2015-10-30 | 2019-02-21 | Ankaa Llc | Method of treating or reducing the severity of dermatological conditions |
| CN105770215A (en) * | 2016-04-29 | 2016-07-20 | 张秀真 | Externally applied unguent for treating allergic dermatitis and preparation method thereof |
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| CN1306822A (en) * | 2000-01-26 | 2001-08-08 | 河源特肤康药业有限公司 | Medicament for treating dermatosis and its preparation |
| CN1679754A (en) * | 2005-01-20 | 2005-10-12 | 李木林 | Strong-effect external-applied preparation for treating multiple skin diseases |
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| CN1306822A (en) * | 2000-01-26 | 2001-08-08 | 河源特肤康药业有限公司 | Medicament for treating dermatosis and its preparation |
| CN1679754A (en) * | 2005-01-20 | 2005-10-12 | 李木林 | Strong-effect external-applied preparation for treating multiple skin diseases |
| CN1768841A (en) * | 2005-10-27 | 2006-05-10 | 湖北鼎龙制药有限公司 | Chinese medicinal compound formulation for treating skin disease |
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