CN115120656A - Medicine for wound repair and preparation method thereof - Google Patents
Medicine for wound repair and preparation method thereof Download PDFInfo
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Abstract
The application provides a medicine for wound repair and a preparation method thereof, and relates to the technical field of medicines. A medicine for wound repair comprises the following components in parts by weight: 80-120 parts of sesame oil, 0.1-5 parts of saffron, 1-15 parts of angelica, 3-20 parts of radix rehmanniae, 4-20 parts of calamine, 2-15 parts of gypsum, 2-15 parts of crinis carbonisatus, 15-30 parts of beeswax, 3-16 parts of vaseline and 2-14 parts of lanolin. The medicine for wound repair has the effects of resisting inflammation, relieving pain, removing blood stasis and stopping bleeding, can promote skin cell tissue regeneration and accelerate wound healing, is mainly used for treating burns and scalds and common trauma, and can also be used for treating postoperative wounds, pressure sores, gangrene, skin ulceration and the like. In the preparation method, the raw materials are decocted in batches, so that the loss of thermosensitive medicinal components can be effectively avoided, the content of the effective components of the medicament is improved, the medicinal effect is enhanced, and the wound repair is accelerated.
Description
Technical Field
The application relates to the technical field of medicines, in particular to a medicine for wound repair and a preparation method thereof.
Background
The wound surface is the damage of normal skin (tissue) caused by the action of external injury factors such as water and fire, sharp instruments and internal factors of the body such as local blood supply disorder. It is often accompanied by a breakdown in the integrity of the skin and the loss of a certain amount of normal tissue, while the normal function of the skin is impaired, also known as a wound or trauma, wound repair, i.e. wound repair. At present, medicines for wound repair have different curative effects on wound injuries under different conditions, and part of medicines have irritation, so that the pain of patients during treatment can be enhanced.
Disclosure of Invention
The application aims to provide a medicament for wound repair, which has the effects of resisting inflammation, easing pain, removing blood stasis and stopping bleeding, can promote skin cell tissue regeneration and accelerate wound healing, is mainly used for treating burns and scalds and common trauma, and can also be used for treating postoperative wounds, pressure sores, gangrene, skin ulceration and the like.
Another objective of the present application is to provide a method for preparing a drug for wound healing, which can effectively avoid the loss of heat-sensitive drug ingredients, improve the content of drug active ingredients, enhance drug efficacy, and accelerate wound healing by decocting the raw materials in batches.
The technical problem to be solved by the application is achieved by adopting the following technical scheme.
The application provides a medicine for wound repair, which comprises the following raw materials in parts by weight: 80-120 parts of sesame oil, 0.1-5 parts of saffron, 1-15 parts of angelica, 3-20 parts of radix rehmanniae, 4-20 parts of calamine, 2-15 parts of gypsum, 2-15 parts of crinis carbonisatus, 15-30 parts of beeswax, 3-16 parts of vaseline and 2-14 parts of lanolin.
The application provides a preparation method of a medicine for wound repair, which comprises the following steps:
heating oleum Sesami, decocting radix rehmanniae for 5-10min, adding radix Angelicae sinensis, decocting for 3-8min, and taking out to obtain unguent A and medicinal liquid A; adding oleum Sesami into the medicinal liquid A, heating, adding Galamina and Gypsum Fibrosum, decocting for 2-6min, adding stigma croci Sativi, decocting for 4-10min, and taking out to obtain unguent B and medicinal liquid B; adding oleum Sesami into the medicinal liquid B, heating, adding Cera flava, vaseline and lanolin, and decocting for 5-10min to obtain medicinal material; mixing the paste A, paste B and the medicinal materials, cooling, adding crinis Carbonisatus, stirring, mixing, and cooling.
The embodiment of the application has at least the following beneficial effects:
in the application, the saffron has the effects of promoting blood circulation to remove blood stasis, cooling blood and detoxifying, resisting inflammation and improving circulation; the angelica has the effects of enriching and activating blood, resisting inflammation, easing pain, stopping bleeding and resisting bacteria; radix rehmanniae has effects in clearing away heat, cooling blood, nourishing yin, promoting salivation, inhibiting bacteria, stopping bleeding, and relieving inflammation; galamina has effects of eliminating dampness, healing sore, removing toxic substance, promoting granulation, relieving itching, inhibiting bacteria, diminishing inflammation, and relieving pain; gypsum Fibrosum has effects of clearing heat, lowering fire, removing toxic substance, promoting granulation, eliminating dampness, healing sore, and stopping bleeding; crinis Carbonisatus has astringent, hemostatic, blood stasis dispelling, antiinflammatory, and antibacterial effects; beeswax has effects of removing toxic substance, healing sore, promoting granulation, relieving pain, and inhibiting bacteria; the sesame oil has the effects of detoxifying, promoting granulation, moistening skin and relieving pain; vaseline and lanolin can promote skin absorption and keep skin moist. The active ingredients are cooperated for use, so that the drug effect is promoted, and the wound healing is realized by the combined action of promoting the generation and the transformation of granulation tissues, improving the circulation, reducing the exudation of secretion, isolating the contact of bacteria and skin and moistening the skin, so that the drug not only can be used for treating burn and scald and common trauma, but also can be used for treating postoperative wounds, pressure sores, gangrene, skin ulceration, diabetic feet, old rotten legs and the like, and has more comprehensive efficacy and higher practicability. The medicine belongs to a wet therapy, and is typically different from the traditional therapy in that scabbing is not generated, and the medicine can directly remove the rotten skin and grow the flesh and the skin without pain.
In the application, the raw materials are decocted in batches, so that the loss of thermosensitive drug ingredients can be effectively avoided, the content of the active ingredients of the drug is improved, the drug effect is enhanced, the growth of granulation tissues and epidermal cells is promoted, and the wound repair is accelerated.
Drawings
FIG. 1 is a schematic representation of clinical example 1 of the present application;
FIG. 2 is a schematic diagram of clinical example 2 of the present application;
FIG. 3 is a schematic representation of clinical example 3 of the present application;
FIG. 4 is a schematic representation of clinical example 4 of the present application.
The figure is as follows: a is a schematic diagram before using the medicine; b is a schematic diagram after the medicament is used.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
Burn and scald are acute injuries caused by fire-heat toxin acting on the body, skin and hair are damaged externally and muscles, bones and muscles are damaged even if the fire-heat toxin is mild, and fluid is consumed by yin because the fire-heat toxin is exuberant, so that toxin invades nutrient and blood and attacks viscera internally to threaten life. One of the important problems faced by tissue regeneration from burns is the inflammatory reaction of the burn wound and the oxidation reaction in the ecological tissue, the barrier effect of the skin disappears after the burn, the exudate of the wound rich in nutrient substances is a good culture medium of bacteria, which aggravates the inflammatory reaction of local wound and even whole body, and good blood circulation is an essential factor for wound healing. For a patient with skin injury after burn and scald, burning pain is the main characteristic, infection control is the key, and the principle is mainly heat clearing and detoxifying, swelling and pain relieving, dampness removing and tissue regeneration promoting; for skin injury patients with common trauma, postoperative injury and pressure sore, the swelling and pain is mainly characterized by promoting blood circulation by removing blood stasis, resisting inflammation and relieving pain, and sterilizing. Thus, the following formulation was used in this example to treat wound injury.
A medicine for wound repair comprises the following raw materials in parts by weight: 80-120 parts of sesame oil, 0.1-5 parts of saffron, 1-15 parts of angelica, 3-20 parts of radix rehmanniae, 4-20 parts of calamine, 2-15 parts of gypsum, 2-15 parts of crinis carbonisatus, 15-30 parts of beeswax, 3-16 parts of vaseline and 2-14 parts of lanolin.
The sesame oil has the effects of detoxifying, promoting tissue regeneration, moistening skin and relieving pain, has the smallest molecular weight and stronger lipophilicity, can prevent water from evaporating, and creates a physiological moist environment for the new skin tissue, so that the generation and transformation of granulation tissue are promoted, and the regeneration of wound skin is realized.
Saffron is sweet in taste, slightly sour, flat and nontoxic, enters heart and liver channels, has the effects of promoting blood circulation to remove blood stasis, cooling blood and detoxifying, dispersing stagnation and releasing stagnation, protecting liver and benefiting gallbladder and soothing nerves, and is used for treating depression and stagnation, chest distress, hematemesis, typhoid fever, absentmindedness, amenorrhea, postpartum blood stasis and abdominal pain and traumatic injury and swelling pain. Crocin has effects of resisting oxidation, resisting inflammation, improving circulation, etc., and has positive effect on healing burn wound.
Chinese angelica is warm in nature, sweet and pungent in flavor, enters liver channel, heart channel and spleen channel, and has the effects of enriching and activating blood, regulating menstruation and relieving pain, relaxing bowel, resisting inflammation and relieving pain. It has hemostatic effect, and can dilate blood vessel in skin tissue, promote epithelial tissue growth, and inhibit bacteria such as Bacillus typhi, Bacillus dysenteriae, and Staphylococcus.
Radix rehmanniae, cold in nature, sweet in taste, and entering heart, liver and kidney meridians, has effects of clearing heat, cooling blood, nourishing yin, promoting fluid production, improving immunity, lowering blood sugar, resisting tumor, resisting allergy, protecting cardiovascular system, resisting fungi, stopping bleeding, resisting disseminated intravascular coagulation, and resisting inflammation and immunity.
Galamina has mild property and sweet taste, enters liver channel and spleen channel, has effects of removing toxic substance, improving eyesight, removing nebula, eliminating dampness, relieving itching, healing sore, removing toxic substance and promoting granulation, can be used for treating skin inflammation or surface wound, can partially dissolve, absorb secretion of pasture wound surface to astringe, can kill local staphylococcus and limit its reproduction, and has good effects of diminishing inflammation and relieving pain.
Gypsum, being cold in nature, sweet and pungent in flavor, enters lung and stomach meridians, and has the effects of clearing heat and lowering fire, relieving restlessness and quenching thirst, and detoxifying and promoting granulation. Calcined gypsum is preferably used, the nature of cold and cool is weaker than that of gypsum, the effects of astringing dampness, healing sore and stopping bleeding are enhanced, and the plaster is commonly used for treating water-fire scald, traumatic bleeding and other symptoms. It can promote wound healing, reduce secretion exudation, prevent infection, and promote wound healing.
Crinis Carbonisatus, mild in nature, bitter in taste, entering liver meridian and stomach meridian, astringing to stop bleeding, removing blood stasis, promoting urination, and has hemostatic, anti-inflammatory and anti-pathogenic microorganism effects. Crinis Carbonisatus mainly contains reflex keratin and key, potassium, zinc, copper, ferrum, manganese, arsenic and other microelements; the organic matter mainly contains cystine, hair melanin composed of sulfur amino acid and non-sulfur amino acid; has the effects of shortening coagulation time and plasma recalcification time; has strong inhibiting effect on Staphylococcus aureus, typhoid bacillus, Parawound bacillus A and Shigella flexneri. The carbonized hair, the sesame oil and the beeswax have the functions of removing the necrotic tissue and promoting the granulation after being decocted.
Beeswax, sweet in taste and slightly warm in nature, enters spleen meridian, has the effects of detoxifying, healing sore, promoting granulation and relieving pain, and is commonly used for unhealed ulcer, ecthyma erosion, traumatic ulceration and burn and scald. Beeswax acts as an anti-inflammatory agent against skin inflammation by inhibiting candida albicans and staphylococcus aureus.
The vaseline can keep the skin moist, so that skin tissues at the wound part can be kept in the optimal state, and the self-repairing capability of the skin is accelerated; can prevent bacteria in the air from contacting with the skin, and reduce the risk of wound infection. It has antiinflammatory, moistening and moisturizing effects, and has no irritation, and can promote skin to absorb effective components of medicine to accelerate wound repair.
Lanolin can delay water loss of skin, and has effects of lubricating skin, caring skin. When the composition is used in combination with vaseline, the permeability of vaseline can be increased, the permeability of effective components to skin can be further improved, and skin absorption can be promoted.
The saffron has the effects of promoting blood circulation, removing blood stasis, cooling blood, removing toxic substances, resisting inflammation and improving circulation; the angelica has the effects of enriching and activating blood, resisting inflammation, easing pain, stopping bleeding and resisting bacteria; radix rehmanniae has effects in clearing away heat, cooling blood, nourishing yin, promoting salivation, inhibiting bacteria, stopping bleeding, and relieving inflammation; galamina has effects of eliminating dampness, healing sore, removing toxic substance, promoting granulation, relieving itching, inhibiting bacteria, diminishing inflammation, and relieving pain; gypsum Fibrosum has effects of clearing heat, lowering fire, removing toxic substance, promoting granulation, eliminating dampness, healing sore, and stopping bleeding; crinis Carbonisatus has astringent, hemostatic, blood stasis dispelling, antiinflammatory, and antibacterial effects; beeswax has effects of removing toxic substance, healing sore, promoting granulation, relieving pain, and inhibiting bacteria; the sesame oil has the effects of detoxifying, promoting granulation, moistening skin and relieving pain; vaseline and lanolin can promote skin absorption and keep skin moist. The active ingredients are cooperated for use, so that the drug effect is promoted, and the wound healing is realized by the combined action of promoting the generation and the transformation of granulation tissues, improving the circulation, reducing the exudation of secretion, isolating the contact of bacteria and skin and moistening the skin, so that the drug not only can be used for treating burn and scald and common trauma, but also can be used for treating postoperative wounds, pressure sores, gangrene, skin ulceration, diabetic feet, old rotten legs and the like, and the drug has more comprehensive efficacy and higher practicability. The medicine belongs to a wet therapy, and is typically different from the traditional therapy in that scabbing is not generated, and the medicine can directly remove the rotten skin and grow the flesh and the skin without pain.
In detail, the medicine for wound repair comprises 90-100 parts of sesame oil, 0.1-0.5 part of saffron, 4-7 parts of angelica, 5-10 parts of radix rehmanniae, 5-10 parts of calamine, 4-8 parts of gypsum, 4-8 parts of crinis carbonisatus, 20-28 parts of beeswax, 5-10 parts of vaseline and 4-8 parts of lanolin, by weight.
In detail, the medicine for wound repair comprises, by weight, 95 parts of sesame oil, 0.32 part of saffron crocus, 5.2 parts of angelica sinensis, 8 parts of radix rehmanniae, 7.2 parts of calamine, 6 parts of gypsum, 6 parts of crinis carbonisatus, 24 parts of beeswax, 8 parts of vaseline and 6 parts of lanolin.
A preparation method of a medicine for wound repair comprises the following steps:
crushing radix rehmanniae, radix Angelicae sinensis, Galamina, Gypsum Fibrosum and crinis Carbonisatus into powder with particle diameter less than 2mm, heating 50 kg oleum Sesami to 240-; adding 20 jin of oleum Sesami into the medicinal liquid A, heating to 240 ℃ and 270 ℃, heating at the rate of 3-8 ℃/min, adding calamine and gypsum, decocting for 2-6min, adding stigma croci Sativi, decocting for 4-10min, and taking out to obtain ointment B and medicinal liquid B; adding 25 jin of sesame oil into the liquid medicine B, heating to 240 ℃ and 270 ℃, heating at the rate of 3-8 ℃/min, adding beeswax, vaseline and lanolin, and decocting for 5-10min to obtain a medicinal material; mixing the paste A, the paste B and the medicinal materials, cooling to 35-50 deg.C at a cooling rate of 1-4 deg.C/min, adding crinis Carbonisatus, stirring and mixing at 100-200r/min for 10-30min, homogenizing at 10-20MPa for 5-10min, cooling, and bottling.
By decocting the raw materials in batches, the loss of thermosensitive drug ingredients can be effectively avoided, the content of the drug active ingredients is improved, the drug effect is enhanced, the growth of granulation tissues and epidermal cells is promoted, and the wound repair is accelerated.
Heating the sesame oil, adding the sesame oil into the liquid medicine A, and adding the sesame oil into the liquid medicine B, wherein the mass ratio of the sesame oil is 5: 2: (2-3).
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A preparation method of a medicine for wound repair comprises the following steps:
raw materials: 95 jin of sesame oil, 0.32 jin of saffron, 5.2 jin of angelica, 8 jin of radix rehmanniae, 7.2 jin of calamine, 6 jin of gypsum, 6 jin of crinis carbonisatus, 24 jin of beeswax, 8 jin of vaseline and 6 jin of lanolin;
firstly, crushing the rehmannia root, the Chinese angelica, the calamine, the gypsum and the crinis carbonisatus powder to the particle size of less than 2 mm;
heating oleum Sesami 50 jin to 260 deg.C, heating at 4 deg.C/min, decocting in radix rehmanniae for 8min, adding radix Angelicae sinensis, decocting for 6min, and taking out to obtain unguent A and medicinal liquid A;
adding 20 jin of oleum Sesami into the medicinal liquid A, heating to 260 deg.C, heating at 4 deg.C/min, adding Galamina and Gypsum Fibrosum, decocting for 2min, adding stigma croci Sativi, decocting for 5min, and taking out to obtain unguent B and medicinal liquid B;
adding 25 jin of sesame oil into the liquid medicine B, heating to 260 ℃, heating at the rate of 4 ℃/min, adding beeswax, vaseline and lanolin, and decocting for 6min to obtain a medicinal material;
mixing the paste A, paste B and materials, cooling to 40 deg.C at a rate of 3 deg.C/min, adding crinis Carbonisatus, stirring at 150r/min for 20min, homogenizing under 15MPa for 8min, cooling, and bottling.
Example 2
A preparation method of a medicine for wound repair comprises the following steps:
raw materials: 90 jin of sesame oil, 0.1 jin of saffron, 4 jin of angelica, 5 jin of radix rehmanniae, 5 jin of calamine, 4 jin of gypsum, 4 jin of crinis carbonisatus, 20 jin of beeswax, 5 jin of vaseline and 4 jin of lanolin;
firstly, crushing the rehmannia root, the Chinese angelica, the calamine, the gypsum and the crinis carbonisatus powder to the particle size of less than 2 mm;
heating oleum Sesami 50 jin to 240 deg.C at a heating rate of 3 deg.C/min, decocting in radix rehmanniae for 5min, adding radix Angelicae sinensis, decocting for 3min, and taking out to obtain unguent A and medicinal liquid A;
adding 20 jin of oleum Sesami into the medicinal liquid A, heating to 240 deg.C, heating at 3 deg.C/min, adding Galamina and Gypsum Fibrosum, decocting for 2min, adding stigma croci Sativi, decocting for 4min, and taking out to obtain unguent B and medicinal liquid B;
adding 20 jin of sesame oil into the liquid medicine B, heating to 240 ℃, heating at the rate of 3 ℃/min, adding beeswax, vaseline and lanolin, and decocting for 5min to obtain a medicinal material;
mixing the ointment A, the ointment B and the medicinal materials, cooling to 35 deg.C at a cooling rate of 1 deg.C/min, adding crinis Carbonisatus, stirring and mixing at 100r/min for 10min, homogenizing at 10MPa for 5min, cooling, and bottling.
Example 3
A preparation method of a medicine for wound repair comprises the following steps:
raw materials: 100 jin of sesame oil, 0.5 jin of saffron, 7 jin of Chinese angelica, 10 jin of rehmannia root, 10 jin of calamine, 8 jin of gypsum, 8 jin of carbonized human hair, 28 jin of beeswax, 10 jin of vaseline and 8 jin of lanolin;
firstly, crushing the rehmannia root, the Chinese angelica, the calamine, the gypsum and the crinis carbonisatus powder to the particle size of less than 2 mm;
heating oleum Sesami 50 jin to 270 deg.C at a heating rate of 8 deg.C/min, decocting in radix rehmanniae for 10min, adding radix Angelicae sinensis, decocting for 8min, and taking out to obtain unguent A and medicinal liquid A;
adding oleum Sesami 20 jin into the medicinal liquid A, heating to 270 deg.C, heating at a rate of 8 deg.C/min, adding Galamina and Gypsum Fibrosum, decocting for 6min, adding stigma croci Sativi, decocting for 10min, and taking out to obtain unguent B and medicinal liquid B;
adding 30 jin of sesame oil into the liquid medicine B, heating to 270 ℃, heating at the rate of 8 ℃/min, adding beeswax, vaseline and lanolin, and decocting for 10min to obtain a medicinal material;
mixing the paste A, paste B and materials, cooling to 50 deg.C at a cooling rate of 4 deg.C/min, adding crinis Carbonisatus, stirring and mixing at 200r/min for 30min, homogenizing at 20MPa for 10min, cooling, and bottling.
Example 4
A preparation method of a medicine for wound repair comprises the following steps:
raw materials: 92 jin of sesame oil, 0.3 jin of saffron, 5 jin of angelica, 7 jin of radix rehmanniae, 6 jin of calamine, 5 jin of gypsum, 5 jin of crinis carbonisatus, 22 jin of beeswax, 6 jin of vaseline and 5 jin of lanolin;
firstly, crushing the rehmannia root, the Chinese angelica, the calamine, the gypsum and the crinis carbonisatus powder to the particle size of less than 2 mm;
heating oleum Sesami 50 jin to 250 deg.C at a heating rate of 5 deg.C/min, decocting in radix rehmanniae for 6min, adding radix Angelicae sinensis, decocting for 4min, and taking out to obtain unguent A and medicinal liquid A;
adding oleum Sesami 20 jin into the medicinal liquid A, heating to 265 deg.C, heating at 6 deg.C/min, adding Galamina and Gypsum Fibrosum, decocting for 5min, adding stigma croci Sativi, decocting for 8min, and taking out to obtain unguent B and medicinal liquid B;
adding 22 jin of sesame oil into the liquid medicine B, heating to 255 ℃, heating at the rate of 6 ℃/min, adding beeswax, vaseline and lanolin, and decocting for 7min to obtain a medicinal material;
mixing the ointment A, the ointment B and the medicinal materials, cooling to 45 deg.C at a cooling rate of 2 deg.C/min, adding crinis Carbonisatus, stirring and mixing at 140r/min for 15min, homogenizing at 12MPa for 7min, cooling, and bottling.
Example 5
A preparation method of a medicine for wound repair comprises the following steps:
raw materials: 98 jin of sesame oil, 0.4 jin of saffron, 6 jin of angelica, 9 jin of radix rehmanniae, 9 jin of calamine, 7 jin of gypsum, 7 jin of crinis carbonisatus, 26 jin of beeswax, 9 jin of vaseline and 7 jin of lanolin;
firstly, crushing the rehmannia root, the Chinese angelica, the calamine, the gypsum and the crinis carbonisatus powder to the particle size of less than 2 mm;
heating oleum Sesami 50 jin to 248 deg.C at a heating rate of 3.5 deg.C/min, decocting radix rehmanniae for 7min, adding radix Angelicae sinensis, decocting for 4min, and taking out to obtain unguent A and medicinal liquid A;
adding oleum Sesami 20 jin into the medicinal liquid A, heating to 256 deg.C, heating at a rate of 4 deg.C/min, adding Galamina and Gypsum Fibrosum, decocting for 3min, adding stigma croci Sativi, decocting for 5min, and taking out to obtain unguent B and medicinal liquid B;
adding 25 jin of sesame oil into the liquid medicine B, heating to 264 ℃, heating at the rate of 4.5 ℃/min, adding beeswax, vaseline and lanolin, and decocting for 7min to obtain a medicinal material;
mixing the paste A, paste B and materials, cooling to 48 deg.C at a rate of 2.5 deg.C/min, adding crinis Carbonisatus, stirring at 180r/min for 22min, homogenizing under 16MPa for 8min, cooling, and bottling.
Test results
50 patients with moderate skin injuries caused by burns and scalds are selected, the patients show local large blisters and difficult pain, the age is 30-40 years old, the patients are randomly divided into 5 groups, 10 people are selected from each group, 1-5 groups respectively correspond to the medicines used in the examples 1-5, and the using method is as follows: the medicine is applied on wound surface until completely covering the wound surface, 1 time per day, and is continuously used for 15 days. After 15 days, the recovery of the patients was counted, and the results are shown in Table 1.
The evaluation standard of curative effect is as follows: refer to the "standards of the Chinese medicine industry of the people's republic of China" made by the national State administration of traditional Chinese medicine of 1994. And (3) healing: the wound surface is completely healed, the epithelium of the wound surface is completely covered, and the scar is solid; the effect is shown: the wound surface is reduced by more than 75 percent, the granulation tissue of the wound surface is fresh, and the color is bright red; improvement: the wound surface is reduced by 25-75%, and granulation tissue of the wound surface is fresh and red; and (4) invalidation: the wound surface is reduced by less than 25 percent, the granulation tissue of the wound surface is dark in color and grows well, and no obvious reduction trend exists.
TABLE 1 test results
| Group of | 1 | 2 | 3 | 4 | 5 |
| Recovery method | 10 | 8 | 7 | 9 | 9 |
| Show effect | 0 | 2 | 2 | 1 | 1 |
| Improvement of life | 0 | 0 | 1 | 0 | 0 |
| Invalidation | 0 | 0 | 0 | 0 | 0 |
According to table 1, the medicine for wound repair prepared by the application has a remarkable treatment effect on patients with moderate burns and scalds, and the cure rate is 100%.
Clinical examples
1. Li Shi, female, 50 years old, burn and scald, local large blister and intolerable pain. The medicine is applied to the affected part for 5 minutes to relieve pain, once a day, and the affected part is healed after 15 days without scars. The results are shown in FIG. 1.
2. Song Dynasty, male, age 40, paraplegia of the lower limbs caused pressure sores. The medicine is applied to the affected part once a day, and the affected part is healed after 3 months. The results are shown in FIG. 2.
3. When a male is in age of 4 years old, the medicine is applied to the affected part once a day and the disease is healed in 20 days. The results are shown in FIG. 3.
4. Wangzhi, 55 years old, was cut by a pulverizer, and the medicine was applied to the affected part once a day for 20 days to heal. The results are shown in FIG. 4.
In summary, in the drug for wound repair in the embodiment of the present application, saffron has the effects of promoting blood circulation to remove blood stasis, cooling blood, removing toxicity, resisting inflammation and improving circulation; the angelica has the effects of enriching and activating blood, resisting inflammation, easing pain, stopping bleeding and resisting bacteria; radix rehmanniae has effects in clearing away heat, cooling blood, nourishing yin, promoting salivation, inhibiting bacteria, stopping bleeding, and relieving inflammation; galamina has effects of eliminating dampness, healing sore, removing toxic substance, promoting granulation, relieving itching, inhibiting bacteria, diminishing inflammation, and relieving pain; gypsum Fibrosum has effects of clearing heat, lowering fire, removing toxic substance, promoting granulation, eliminating dampness, healing sore, and stopping bleeding; crinis Carbonisatus has astringent, hemostatic, blood stasis removing, antiinflammatory, and antibacterial effects; beeswax has effects of removing toxic substance, healing sore, promoting granulation, relieving pain, and inhibiting bacteria; the sesame oil has the effects of detoxifying, promoting granulation, moistening skin and relieving pain; vaseline and lanolin can promote skin absorption and keep skin moist. The active ingredients are cooperated for use, so that the drug effect is promoted, and the wound healing is realized by the combined action of promoting the generation and the transformation of granulation tissues, improving the circulation, reducing the exudation of secretion, isolating the contact of bacteria and skin and moistening the skin, so that the drug not only can be used for treating burn and scald and common trauma, but also can be used for treating postoperative wounds, pressure sores, gangrene, skin ulceration, diabetic feet, old rotten legs and the like, and the drug has more comprehensive efficacy and higher practicability.
According to the preparation method of the medicine for wound repair, the raw materials are decocted in batches, so that the loss of thermosensitive medicine components can be effectively avoided, the content of the effective components of the medicine is improved, the medicine effect is enhanced, the growth of granulation tissues and epidermal cells is promoted, and the wound repair is accelerated.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (10)
1. The medicine for wound repair is characterized by comprising the following raw materials in parts by weight: 80-120 parts of sesame oil, 0.1-5 parts of saffron, 1-15 parts of angelica, 3-20 parts of radix rehmanniae, 4-20 parts of calamine, 2-15 parts of gypsum, 2-15 parts of crinis carbonisatus, 15-30 parts of beeswax, 3-16 parts of vaseline and 2-14 parts of lanolin.
2. A medicament for wound repair according to claim 1, comprising 90-100 parts by weight of sesame oil, 0.1-0.5 part by weight of saffron crocus, 4-7 parts by weight of angelica, 5-10 parts by weight of rehmannia root, 5-10 parts by weight of calamine, 4-8 parts by weight of gypsum, 4-8 parts by weight of crinis carbonisatus, 20-28 parts by weight of beeswax, 5-10 parts by weight of vaseline and 4-8 parts by weight of lanolin.
3. A medicament for wound repair according to claim 2, comprising 95 parts sesame oil, 0.32 parts saffron, 5.2 parts angelica, 8 parts radix rehmanniae, 7.2 parts calamine, 6 parts gypsum, 6 parts crinis carbonisatus, 24 parts beeswax, 8 parts vaseline and 6 parts lanolin, all by weight.
4. A method of preparing a medicament as claimed in any one of claims 1 to 3 for wound repair, comprising the steps of:
heating oleum Sesami, adding radix rehmanniae, decocting for 5-10min, adding radix Angelicae sinensis, decocting for 3-8min, and taking out to obtain unguent A and medicinal liquid A; adding oleum Sesami into the medicinal liquid A, heating, adding Galamina and Gypsum Fibrosum, decocting for 2-6min, adding stigma croci Sativi, decocting for 4-10min, and taking out to obtain unguent B and medicinal liquid B; adding oleum Sesami into the medicinal liquid B, heating, adding Cera flava, vaseline and lanolin, and decocting for 5-10min to obtain medicinal material; mixing the paste A, paste B and the medicinal materials, cooling, adding crinis Carbonisatus, stirring, mixing, and cooling.
5. A method for preparing a medicament for wound healing as claimed in claim 4, wherein the raw materials further comprise radix rehmanniae, radix Angelicae sinensis, Calamina, Gypsum Fibrosum, and crinis Carbonisatus powder pulverized to particle size of less than 2mm before use.
6. The method for preparing a drug for wound healing according to claim 4, wherein the heating is carried out at a temperature of 240 ℃ and 270 ℃ at a heating rate of 3-8 ℃/min.
7. The method for preparing a medicine for wound healing according to claim 4, wherein when the sesame oil is heated, the sesame oil is added into the liquid medicine A, and the sesame oil is added into the liquid medicine B, the mass ratio of the sesame oil is 5: 2: (2-3).
8. A method for preparing a medicament for wound healing as claimed in claim 4, wherein the temperature is reduced to 35-50 ℃ at a rate of 1-4 ℃/min.
9. The method for preparing a drug for wound healing according to claim 4, wherein the stirring is performed at 200r/min for 10-30min during the stirring and mixing.
10. A method for preparing a medicament for wound healing as claimed in claim 9, further comprising homogenizing at 10-20MPa for 5-10min after mixing with stirring.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741353B1 (en) * | 2014-01-27 | 2014-06-03 | May Ghaith M. Al-Mutawaa | Ointment for healing burns and wounds |
| CN106619991A (en) * | 2017-02-08 | 2017-05-10 | 泰州市姜堰中医院 | Granulation-promoting adhesive plaster |
| CN110215497A (en) * | 2019-06-28 | 2019-09-10 | 甘肃中医药大学 | A kind of skin repair cream and its preparation process |
| CN113209199A (en) * | 2021-05-31 | 2021-08-06 | 安徽济梵生医药生物科技有限公司 | Pure traditional Chinese medicine oil agent for promoting wound healing and application method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741353B1 (en) * | 2014-01-27 | 2014-06-03 | May Ghaith M. Al-Mutawaa | Ointment for healing burns and wounds |
| CN106619991A (en) * | 2017-02-08 | 2017-05-10 | 泰州市姜堰中医院 | Granulation-promoting adhesive plaster |
| CN110215497A (en) * | 2019-06-28 | 2019-09-10 | 甘肃中医药大学 | A kind of skin repair cream and its preparation process |
| CN113209199A (en) * | 2021-05-31 | 2021-08-06 | 安徽济梵生医药生物科技有限公司 | Pure traditional Chinese medicine oil agent for promoting wound healing and application method thereof |
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| Title |
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| 马振友等: "《新编中西皮肤药物手册》" * |
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