CN108785530A - A kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof - Google Patents

A kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof Download PDF

Info

Publication number
CN108785530A
CN108785530A CN201810999828.0A CN201810999828A CN108785530A CN 108785530 A CN108785530 A CN 108785530A CN 201810999828 A CN201810999828 A CN 201810999828A CN 108785530 A CN108785530 A CN 108785530A
Authority
CN
China
Prior art keywords
ointment
liquefaction
powder
healing skin
growing muscle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201810999828.0A
Other languages
Chinese (zh)
Inventor
董如金
董胜云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201810999828.0A priority Critical patent/CN108785530A/en
Publication of CN108785530A publication Critical patent/CN108785530A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/32Manganese; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/85Verbenaceae (Verbena family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22Cysteine endopeptidases (3.4.22)
    • C12Y304/22004Bromelain (3.4.22.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/35Extraction with lipophilic solvents, e.g. Hexane or petrol ether

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

A kind of liquefaction ointment for growing muscle and healing skin, prescription are preferably:Rapeseed oil, and by based on rapeseed oil weight:Sibirica walking fern herb 3%, leech 4%, the bletilla striata 3%, Radix Notoginseng 3%, peach leaf 3%, Japanses beauty-berry grass 5%, Chinese gall 4%, pyrolusite powder 3%, catechu powder 3%, pearl powder 0.1%-0.6%, bromelain 0.1%-0.2%, beeswax 10%-25%, vaseline 3%.Preparation method is that the brewed rear small fire of the traditional Chinese medicine ingredients such as stirrup grass is added in rapeseed oil to be fried into yellow oil, then sequentially adds beeswax and vaseline and catechu powder while hot, pearl powder and bromelain forms.Suitable for body surface class sore caused by bacterium infection, always rotten lower limb, the rotten foot of diabetes, vasculitis, bedsore, burn and scald, postoperative incision not more and all ulcer, slough be de-, new meat is raw or long cannot the person of closing in, have the function of antibacterial antivirus, Conservative restoration be damaged cortex, promote blood circulation, impermeable surface wound deeply absorbs, is promoting blood circulation and removing blood stasis, swelling and pain relieving, promotion deep spoilage tissue voluntarily liquefy falls off and discharge pus slough etc..

Description

A kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof
Technical field
The present invention relates to field of medical technology, specifically a kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof.
Background technology
The illnesss such as are not more normal for various wounds and sore class (vasculitis, bedsore, ulcer on the shank), scalpel edge in people's life See, not only incidence is high, but also degree difference is very big, and some conditions of the injury are serious and complicated, or even jeopardize the life of the wounded.Currently, The drug for treating above-mentioned illness on the market has very much, but curative effect is different, and the drugs such as clinical common Yunnan Baiyao, burning hot cream all may be used The wounded's slight illness, auxiliary wound healing, but wound of the existing drug for deep skin, wound can be mitigated to a certain extent The therapeutic wound healings less effectives such as pyogenic infection, body surface chronic and refractory ulcer.Treat the common antibiotic of above-mentioned illness Class drug, effect unobvious, and it is expensive, more important is larger side effect can be generated to patient.The side of western medical treatment Method is typically to use debridement, disinfection, wrapping and operation, and the course for the treatment of is long, and healing is slow, costly, and is easy that there are scars more afterwards.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of antibacterial antivirus with gain, Conservative restoration is damaged cortex, promotees It is deeply absorbed into blood circulation, impermeable surface wound, promoting blood circulation and removing blood stasis, swelling and pain relieving, promotion deep spoilage tissue voluntarily liquefy and take off It falls and discharges pus and the functions such as slough, and treatment course is short, the liquefaction ointment for growing muscle and healing skin and preparation method thereof of preventing from scar.
To achieve the goals above, the technical solution of use is as follows:
A kind of liquefaction ointment for growing muscle and healing skin, the prescription that is made for liquefying ointment for growing muscle and healing skin include:Vegetable oil, and by opposite It is calculated in vegetable oil weight:Sibirica walking fern herb 2.8-3.2%, leech 3.7-4.3%, bletilla striata 2.8-3.2%, Radix Notoginseng 2.8-3.2%, Peach leaf 2.8-3.2%, Japanses beauty-berry grass 4.5-5.5%, Chinese gall 3.7-4.3%, pyrolusite powder 2.8-3.2%, catechu powder 2.8- 3.2% (under rear), pearl powder 0.1%-0.6%, bromelain 0.1%-0.2%, beeswax 10%-25%, vaseline 2.8- 3.2%.
A kind of liquefaction ointment for growing muscle and healing skin as described above, the vegetable oil are rapeseed oil.
A kind of liquefaction ointment for growing muscle and healing skin as described above, the bromelain are 300,000 units.
A kind of liquefaction ointment for growing muscle and healing skin as described above, the prescription that is made for liquefying ointment for growing muscle and healing skin include:Vegetable oil, And by calculating relative to vegetable oil weight:Sibirica walking fern herb 3%, leech 4%, the bletilla striata 3%, Radix Notoginseng 3%, peach leaf 3%, Japanses beauty-berry grass 5%, Chinese gall 4%, pyrolusite powder 3%, catechu powder 3%, pearl powder 0.1%-0.6%, bromelain 0.1%-0.2%, Beeswax 10%-25%, vaseline 3%.
A kind of liquefaction ointment for growing muscle and healing skin as described above, by the beeswax 15%- calculated relative to vegetable oil weight 25%.
A kind of preparation method of above-mentioned liquefaction ointment for growing muscle and healing skin, the preparation method include the following steps:
The first step prepares raw material:
Sibirica walking fern herb, leech, the bletilla striata, Radix Notoginseng, peach leaf, Japanses beauty-berry grass, Chinese gall, pyrolusite powder is taken to immerse plant by set weight In oil, place a couple of days, it is spare;
Second step, it is fried:
Ready medicine oil in the first step is taken, medicine oil is placed on fire, small fire is slow to decoct;
Third walks, fried completion:
The medicine oil of each Chinese medicine to be mixed decocts yellowly oil, then fried completion;
Beeswax and vaseline is added in 4th step:
The medicine oil that third step has been decocted is filtered into the dregs of a decoction, the beeswax and vaseline of set weight are added while hot, its whole is made to melt Change;
5th step:Catechu powder, pearl powder and bromelain is added:
Before the medicine oil cooled and solidified that the 4th step obtains, catechu powder, pearl powder and the bromelain of set weight is added.
The preparation method of liquefaction ointment for growing muscle and healing skin as described above further includes:
6th step, it is filling:
It is carried out before the medicine oil cooling that the 5th step obtains filling.
The preparation method of liquefaction ointment for growing muscle and healing skin as described above, it is 7 days or more to place number of days in the first step.
The preparation method of liquefaction ointment for growing muscle and healing skin as described above, small fire is slow in the second step decoct during, often decoct one section Time turns down the duration and degree of heating, then restores again, repeatedly several times.
The preparation method of liquefaction ointment for growing muscle and healing skin as described above, described is 2-6 times repeatedly several times repeatedly.
The beneficial effects of the invention are as follows:
The present invention is based on modern clinic experiences, are formed in conjunction with clinical practice and case research, first in inventive formulation The pharmacological property and pharmacological effect for the every taste medicine being based on carry out as detailed below.
Sibirica walking fern herb, which has, improves autoimmunity, promoting blood circulation and removing blood stasis, hemostasis function of detoxification, primary treatment thrombosis-obstructive vessel The illnesss such as inflammation, the ulcer of lower limb, hemiplegia, traumatic hemorrhage, neurodermatitis;Leech can improve local circulation, be conducive to nervous function Recovery, can thrombus, have effects that dissipating blood stasis with potent drugs dredging collateral, metal-inflicted wound, blood vessel bolt disease such as phlebitis, occlusive can be treated Vasculitis, embolic arteritis etc.;Bletilla striata energy astringing to arrest bleeding, detumescence and promoting granulation can treat traumatic hemorrhage, sore swollen toxin, scald etc.; Radix Notoginseng has dissipate stasis of blood hemostasis, detumescence ding-tong, sore swell and ache curative, trauma hemostasis, disperse blood stasis and dredge collateral and other effects;Peach leaf is killed with wind-damp dispelling Worm, clearing heat and detoxicating, eczema, sore are antipruritic, the functions such as inducing meastruation to relieve menalgia;Japanses beauty-berry grass has hemostasis, antibacterial action to trauma of spleen and wound, Can anti-inflammatory analgetic, have preferable hemostasis work(to dog liver, trauma of spleen, bullet wound using Japanses beauty-berry grass extracting solution as No. 35 styptic powders of main ingredient Energy;Chinese gall can prevent paddy-field dermatitis, treat cervical erosion, there is convergence antibacterial action;There is catechu promoting blood circulation and stopping pain, hygroscopic to hold back Sore, myogenic control ulcer, the functions such as treatment skin eczema;Pyrolusite is relieved pain with stasis eliminatings, detumescence and promoting granulation, the main metal-inflicted wound function of ulcer on the shank; Pearl powder can adjust endocrine, solve taking poison and growing muscle due, to knife wound, scald, burn, can quick-acting haemostatic powder, and it is fast to close up, and puts on flesh fast, disappears It is scorching fast, and preventing from scar;Beeswax can detoxify, relieve pain, and have treatment burn and scald, myogenic sore pain inside fire attack burst for a long time and does not holds back, dermatitis and eczema etc. Function can receive cream;Select the rape seed oil in vegetable oil, clearing liver cholagogic, anti-inflammatory skin care that can soften blood vessel.What the present invention selected Above-mentioned Chinese medicine, is consistent inside and outside being pharmacologically particular about, and is particular about in effect and efficiently suits the medicine to the illness.
Bromelain is combined in the formula of the present invention, uses the principle of zymetology debridement, zymetology debridement is to use certain A little exogenous enzymes with proteolysis remove the tissue breakdown of necrosis or inactivation, while not damaging normal group neighbouring It knits.Due to the effect for the inhibiting factor that cell generates, these exogenous proteases usually will not generate hydrolysis to living tissue, Necrosis or devitalized tissue are only decomposed, so as to play the role of the debridement with high selectivity in theory.Passing through pineapple egg After the catharsis of white enzyme, liquefaction ointment for growing muscle and healing skin then can farthest transfer the immune system of body itself, and the surface of a wound is made to produce The raw nutrient solution rich in immunocompetent cell and total local capilary for sticking active factors, can effectively adjust wound tissue cell Function, to anti-infective and promotion organization healing.Various wounds are not cured, using different external therapys, the present invention attempts will be with Relative to vegetable oil (rapeseed oil) weight meter, the bromelain of 0.1%-0.2% is added in liquefaction ointment for growing muscle and healing skin, " changes rotten Method of reproduction " achieves preferable effect, promotes the immediate union of the surface of a wound, shortens the treatment time of patient.
Its scope of application of liquefaction ointment for growing muscle and healing skin of the present invention is:It is body surface class sore caused by bacterium infection, old rotten The rotten foot of leg, diabetes, vasculitis, bedsore, burn and scald, postoperative incision are not cured.Not suitable for not de-, the new meat of all ulcer, slough Or it long cannot the person of closing in when life.
Each taste prescription drug of the present invention is selected by clinical test for many years many times on the basis of theoretical research Fixed, the dosage of each taste prescription drug is also gone through to be verified repeatedly, this makes its feature of the liquefaction ointment for growing muscle and healing skin of the present invention not be Be limited to more to the ill, purposes is wide, but on the basis of fully having studied the general character of its targeted each indication mainly for The breakthrough of drug effect, therefore it is totally different from all kinds of omnipotent plaster in the market, relative to plaster in the market, liquefaction of the invention Ointment for growing muscle and healing skin more emphasizes the support of mechanism and the castering action of drug effect.
In summary it analyzes, liquefaction ointment for growing muscle and healing skin provided by the present invention, the following functions with gain:1, antibacterial to kill Malicious function;2, Conservative restoration is damaged the function of cortex;3, promote the blood circulation in affected part;4, impermeable surface wound, deeply absorption Function;5, promoting blood circulation and removing blood stasis, swelling and pain relieving function;6, promote deep spoilage tissue voluntarily liquefy fall off and discharge pus and The function of slough.In addition, as another outstanding feature, liquefaction ointment for growing muscle and healing skin provided by the invention, treatment course is short, no Stay scar.
Specific embodiment
The illustrative embodiments of the disclosure are described in more detail below.It is to be appreciated that providing these embodiments is In order to be best understood from the disclosure, and the scope of the present disclosure can be completely communicated to those skilled in the art Member, may be realized in various forms the disclosure, without should be limited by embodiments set forth herein.
Embodiment 1
A kind of liquefaction ointment for growing muscle and healing skin, the prescription that is made for liquefying ointment for growing muscle and healing skin include:Rapeseed oil, and by opposite It is calculated in rapeseed oil weight:Sibirica walking fern herb 3%, leech 4%, the bletilla striata 3%, Radix Notoginseng 3%, peach leaf 3%, Japanses beauty-berry grass 5%, Chinese gall 4%, pyrolusite powder 3%, catechu powder 3% (under rear), pearl powder 0.1%-0.6%, bromelain 0.1%-0.2%, beeswax 15%-25%, vaseline 3%.
The preparation method of above-mentioned liquefaction ointment for growing muscle and healing skin, the preparation method include the following steps:
The first step prepares raw material:
Sibirica walking fern herb, leech, the bletilla striata, Radix Notoginseng, peach leaf, Japanses beauty-berry grass, Chinese gall, pyrolusite powder 8 are taken by the weight of above-mentioned determination Kind Chinese medicine immerses in vegetable oil, place 7 days or more, it is spare;
Second step, it is fried:
Ready medicine oil in the first step is taken, medicine oil is placed on fire, small fire is slow to decoct, and has to here slow with minimum fire It decocts, not paste, during which, often decoct a period of time, the duration and degree of heating is turned down, is then restored again, 2-6 times repeatedly, such as preferably repeatedly 4 It is secondary;
Third walks, fried completion:
The medicine oil of each Chinese medicines such as to be mixed sibirica walking fern herb, leech, Japanses beauty-berry grass decocts yellowly oil, then fried completion, here still So it is noted that cannot paste, paste that can only just to outwell again feeding fried;
Beeswax and vaseline is added in 4th step:
The medicine oil that third step has been decocted is filtered into the dregs of a decoction, the beeswax and vaseline of above-mentioned determining weight are added while hot, keeps it complete Melt in portion;
5th step:Catechu powder, pearl powder and bromelain is added:
Before the medicine oil cooled and solidified that the 4th step obtains, catechu powder, pearl powder and the pineapple egg of above-mentioned determining weight is added White enzyme.
6th step, it is filling:
It is carried out before the medicine oil cooling that the 5th step obtains filling.
Embodiment 2
The present embodiment be for pearl powder, bromelain, beeswax dosage in embodiment 1 still more preferably, here Still it presses and is calculated relative to rapeseed oil weight, pearl powder 0.3%, bromelain 0.1%, beeswax 20%;Alternatively, pearl powder 0.5%, bromelain 0.2%, beeswax 22%.In addition to this, other prescription dosages of the present embodiment and liquefaction life The preparation method of muscle and healing skin cream is identical as having been described in embodiment 1.
Embodiment 3
A kind of liquefaction ointment for growing muscle and healing skin, the prescription that is made for liquefying ointment for growing muscle and healing skin include:Rapeseed oil, and by opposite It is calculated in rapeseed oil weight:Sibirica walking fern herb 2.9%, leech 4.1%, the bletilla striata 2.9%, Radix Notoginseng 3.2%, peach leaf 2.9%, Japanses beauty-berry grass 5.2%, Chinese gall 3.8%, pyrolusite powder 3.1%, catechu powder 3.2% (under rear), pearl powder 0.2%, bromelain 0.1%, beeswax 20%, vaseline 2.9%.The preparation method of this liquefaction ointment for growing muscle and healing skin, it is in the same manner as in Example 1, it is no longer superfluous It states.
The ointment for growing muscle and healing skin that liquefies described in various embodiments of the present invention can treat the rotten foot of always rotten lower limb, diabetes, osteomyelitis, cotton-padded mattress Sore, postoperative incision be not cured, burn and scald etc., clinical that analysis and pharmacological evaluation are first carried out by taking burn and scald as an example.It is cured using Chinese medicine myogenic Clinical 23 observation of curative effect of skin cream external-used burn and scald treating, for effective percentage up to 100%, cure rate does not stay scar up to 99% or more Trace, short treating period is easy to use, obtains many patients and the approval of medical worker.Now such as by clinical analysis and pharmacological evaluation report Under:
One, analysis
In 23, the oldest 55 years old, minimum 1 years old, male patient 14, female patient 9, maximum area of burning Human body 25% is accounted for, minimum about 3% or so, course of disease longest 98 days is most 1 hour short, 7.7 days average, administration time longest 30 days, most It is 2 days short, it is 16 days average.
Two, drug composition and dosage form
The sibirica walking fern herb of the effects that selecting anti-infective, promoting blood circulation and removing blood stasis, swelling and pain relieving, putrefaction-removing granulation-promoting, sore benefit skin, leech, three The seven equal kinds of traditional Chinese medicines as described in the present embodiment 1, are improved using traditional ointment manufacture craft, are aided with the matrix of moisturizing, are made The pure Chinese medicine external-use ointment for having the non-stimulated odorless of pitch sample gloss as a kind of yellow black, have resistance to evaporation, it is anti-it is dry and cracked without The advantages that being easy to run off.
Three, pharmacological experimental method
Skin irritation test
1, reagent and drug:The second spring depilatory cream:The 9th pharmaceutical factory's product of Shanghai;Chinese medicinal ointment:The Juye clinics Yi Shoushen.
2, animal:The small domesticated dog of adult healthy, 5 kilograms of weight.
3, practice content and method:1. intact skin once daily skin irritatin;2. intact skin multiple dosing skin Stimulation;3. damaged skin single administration skin irritatin;4. the stimulation of damaged skin multiple dosing.
4. result:Above-mentioned four experimental results observation does not occur erythema and oedema, by the scoring of skin wound repair Scale is 0, nonirritant by skin irritatin intensity evaluation standard.
Animal scalds pharmacological action experiment
Experimental method:Healthy domesticated dog 5 is taken, back is lost hair or feathers 200cm2After 24 hours, domesticated dog is fixed, uses liquid wax Constant temperature ----metal object is in direct contact 5 seconds, contact area 30*15cm at 200 ± 1 DEG C with dog skin2, every 4 pieces of domesticated dog scald, And 4 groups are randomly divided into, it is confirmed as II ° of scald through pathological examination.
1. administration group:Apply Chinese medicinal ointment;2. positive control group:Apply snake oil;3. excipients group:Apply excipients;4. blank Control group:It is without any processing.
Table 1:Experimental result
Group Number of animals (only) Scab forming time (day)
Administration group 5 8±0
Positive group 5 10±4.4
Excipients group 5 13±1.1
Blank control group 5 13±1.2
The result shows that:For administration group compared with blank and excipients group, recovery from illness is very fast, and the positive is slightly faster than compared with positive group Group.
Table 2:Bacteriostatic experiment result
Strain Staphylococcus aureus Pseudomonas aeruginosa Escherichia coli
Strain concentration 0.049% 0.049% 0.049%
Culture medium PH 6.6 7.6 7.6
Antibacterial activity ++ + -
From the experimental results:The medicine has preferable antibacterial ability to staphylococcus aureus, also has antibacterial to Pseudomonas aeruginosa Effect acts on unobvious to Escherichia coli.
Four, it summarizes
We are not cured using the various wounds of Chinese medicine ointment treatment burn, and by pharmacological evaluation and clinic trial, this cream is nontoxic Side effect, treatment time is short, curative for effect.This medicine has infection control, convergence growing muscle and healing skin effect to the surface of a wound, is widely applying In the case of antibiotic, drug resistance is generated quickly, and applies Chinese medicine myogenic paste, can reduce the side effect that Western medicine is brought, and There is apparent analgesic effect, therefore traditional Chinese medicinal ointment is a kind of ideal medicament being worthy of promotion and application.
To further demonstrate that the clinical application of the present invention, some clinical cases are set forth below:
Bedsore model case
×× is opened, it is male, 70 years old, Juye supply and marketing cooperative retired cadre, in June, 2011 because apoplexy (cerebral thrombosis) enters county people People hospital, through medical treatment sb.'s illness took a favorable turn stablize, there are the sequelae such as hemiplegia.Because of long-term bed, limitation of activity, in being admitted to hospital Bedsore is formed after three months at coccyx, through with antibiotic effect unobvious, therefore leaves hospital and arrives here diagnosis and treatment.Symptom body disappeared at that time Thin, sallow complexion is indigestion and loss of appetite, hemiplegia, has at sacrococcyx at the ulcer surface two of 8*3cm sizes, and edge is red and swollen, and there is sheet in centre Adherency, color is dark dim, has thin fester to ooze out, and intermediate visible sclerotin is exposed, 38.9 DEG C of body temperature, with ointment for growing muscle and healing skin sliver to cotton-padded mattress Sore deep is added medicine to, and by ointment ribbon gauze complete mulching sore face, wrapping, dressing once a day, the 6th, slough took off, and edge redness disappears Lose, ulcer surface has the new granulation of pale red to grow, and local circumstance is good within the 9th day, and sore face is reduced into 4*2cm, after use this cream to be total to always Treatment 20 days, sore face all healed.
Ulcer of lower limb model case
×× is opened, it is male, 81 years old, retired employees of brewery of county, first visit on April 23 in 2011.
Main suit:Right lower extremity ulcer 3 days.Medical history:Before 3 days, right lower extremity is scratched by bite by mosquitos, preceding right lower extremity by bite by mosquitos Sore face constantly expands after broken, through multi-treatment, curative effect unobvious.Previously there is double lower limb varication history 11 years, checks right lower extremity See the ulcer of 10cm*8cm at 1/3 under inside, sore covering weave canescence changes, and has downright bad sample tissue, with yellow diffusate, Sore face is recessed, and notch is played on side, and the shallow erosion of ulcer surrounding skin table changes with pigmentation sample, and suffering limb has pitting edema.
Laboratory examination:Blood leukocytes 8.3*109/ L, neutrality 78%, empty stomach blood meal 5.21mmol/L.Diagnosis:Right lower extremity Chronic ulcer.
With liquefaction ointment for growing muscle and healing skin after 3 dressings, sore face slough gradually falls off, and tissue gradually turns fresh and alive, and sees there is new life Granulation is grown, and after continuing dressing 20 days, right lower extremity ulcer surface is obviously reduced, and only there are the sore faces of 3cm*2cm, continue dressing 45 It, sore face all healed and receive work(, with controlling more than 1 year no relapse.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Any one skilled in the art in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in, It should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of the claim Subject to enclosing.

Claims (10)

1. a kind of liquefaction ointment for growing muscle and healing skin, which is characterized in that it is described liquefaction ointment for growing muscle and healing skin the prescription that is made include:Vegetable oil, And by calculating relative to vegetable oil weight:Sibirica walking fern herb 2.8-3.2%, leech 3.7-4.3%, bletilla striata 2.8-3.2%, Radix Notoginseng 2.8-3.2%, peach leaf 2.8-3.2%, Japanses beauty-berry grass 4.5-5.5%, Chinese gall 3.7-4.3%, pyrolusite powder 2.8-3.2%, youngster Tea powder 2.8-3.2% (rear under), pearl powder 0.1%-0.6%, bromelain 0.1%-0.2%, beeswax 10%-25% are all Intellectual circle 2.8-3.2%.
2. a kind of liquefaction ointment for growing muscle and healing skin according to claim 1, which is characterized in that the vegetable oil is rapeseed oil.
3. a kind of liquefaction ointment for growing muscle and healing skin according to claim 1, which is characterized in that the bromelain is 300,000 single Position.
4. according to a kind of liquefaction ointment for growing muscle and healing skin of claim 1-3 any one of them, which is characterized in that the liquefaction myogenic is cured The prescription that is made of skin cream includes:Vegetable oil, and by calculating relative to vegetable oil weight:Sibirica walking fern herb 3%, leech 4%, the bletilla striata 3%, Radix Notoginseng 3%, peach leaf 3%, Japanses beauty-berry grass 5%, Chinese gall 4%, pyrolusite powder 3%, catechu powder 3% (under rear), pearl powder 0.1%-0.6%, bromelain 0.1%-0.2%, beeswax 10%-25%, vaseline 3%.
5. a kind of liquefaction ointment for growing muscle and healing skin according to claim 4, which is characterized in that calculated by relative to vegetable oil weight The beeswax be 15%-25%.
6. a kind of a kind of preparation method of liquefaction ointment for growing muscle and healing skin described in claim 1-5 any one, which is characterized in that institute The preparation method stated includes the following steps:
The first step prepares raw material:
Sibirica walking fern herb, leech, the bletilla striata, Radix Notoginseng, peach leaf, Japanses beauty-berry grass, Chinese gall, pyrolusite powder is taken to immerse vegetable oil by set weight In, it places a couple of days, it is spare;
Second step, it is fried:
Ready medicine oil in the first step is taken, medicine oil is placed on fire, small fire is slow to decoct;
Third walks, fried completion:
The medicine oil of each Chinese medicine to be mixed decocts yellowly oil, then fried completion;
Beeswax and vaseline is added in 4th step:
The medicine oil that third step has been decocted is filtered into the dregs of a decoction, the beeswax and vaseline of set weight are added while hot, it is made all to melt;
5th step:Catechu powder, pearl powder and bromelain is added:
Before the medicine oil cooled and solidified that the 4th step obtains, catechu powder, pearl powder and the bromelain of set weight is added.
7. the preparation method of liquefaction ointment for growing muscle and healing skin according to claim 6, which is characterized in that further include:
6th step, it is filling:
It is carried out before the medicine oil cooling that the 5th step obtains filling.
8. the preparation method of liquefaction ointment for growing muscle and healing skin according to claim 6, which is characterized in that placed in the first step Number of days is 7 days or more.
9. the preparation method of liquefaction ointment for growing muscle and healing skin according to claim 6, which is characterized in that small fire in the second step It is slow to decoct period, a period of time is often decocted, the duration and degree of heating is turned down, is then restored again, repeatedly several times.
10. the preparation method of liquefaction ointment for growing muscle and healing skin according to claim 9, which is characterized in that it is described repeatedly several times It is 2-6 times repeatedly.
CN201810999828.0A 2018-08-30 2018-08-30 A kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof Withdrawn CN108785530A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810999828.0A CN108785530A (en) 2018-08-30 2018-08-30 A kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810999828.0A CN108785530A (en) 2018-08-30 2018-08-30 A kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof

Publications (1)

Publication Number Publication Date
CN108785530A true CN108785530A (en) 2018-11-13

Family

ID=64081599

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810999828.0A Withdrawn CN108785530A (en) 2018-08-30 2018-08-30 A kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof

Country Status (1)

Country Link
CN (1) CN108785530A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114558123A (en) * 2020-12-20 2022-05-31 天津中医药大学第二附属医院 Pharmaceutical composition for treating foot ulcer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114558123A (en) * 2020-12-20 2022-05-31 天津中医药大学第二附属医院 Pharmaceutical composition for treating foot ulcer

Similar Documents

Publication Publication Date Title
US11571452B2 (en) Method of treating a skin wound with a liquid-state topical pharmaceutical composition
CN101310748B (en) Ointment for treating empyrosis
CN106728727A (en) It is a kind of to treat ointment of sore and preparation method thereof
CN102366544A (en) Bedsore ointment and preparation method thereof
CN110292602A (en) Yellow burn oil formula of a kind of compound five and preparation method thereof
CN102357203B (en) Cortex ulmis burn ointment for curing burns
CN103893557A (en) Traditional Chinese medicine preparation for treating bedsore
CN108785530A (en) A kind of liquefaction ointment for growing muscle and healing skin and preparation method thereof
CN101401890B (en) External use medicament capable of effectively treating wound surface infection
CN102872244B (en) Burn and scald treatment medicament and preparation method thereof
CN102698086B (en) Chinese medicinal emulsion for treating bedsore accumulated toxin decay
CN111991471A (en) A topical Chinese medicinal preparation for treating knife wound, burn and scald, and its preparation method
CN101036712A (en) Scald and burn ointment
CN101703739B (en) Chinese medicinal linimentum for treating trauma and traumatic infection
CN104147315A (en) Emulsion medicine for treating scald and burn and preparation method thereof
CN110859902A (en) Medicine for treating burn, scald and trauma
CN110384748A (en) A kind of weapons wound badu shengji powder
CN110063992A (en) Burn and scald medication and preparation method thereof
CN102178795B (en) External medicine for treating burns and scalds and preparation method of medicine
CN106728069A (en) It is a kind of to treat the putrefaction-removing granulation-promoting paste for scalding burn
CN101357153B (en) No-scar medicine for treating burn and scald and preparation method thereof
CN115120656A (en) Medicine for wound repair and preparation method thereof
CN113768993A (en) A Chinese medicinal composition for treating soft tissue contusion such as burn, scald and bedsore, and its preparation method
CN104435730A (en) Externally applied traditional Chinese medicine ointment for treating skin ulcer
CN116531460A (en) Traditional Chinese medicine powder for treating huge bedsores and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication

Application publication date: 20181113

WW01 Invention patent application withdrawn after publication