CN101036713A - Shumitong concentrated pill and the method for preparing the same - Google Patents
Shumitong concentrated pill and the method for preparing the same Download PDFInfo
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- CN101036713A CN101036713A CN 200610065789 CN200610065789A CN101036713A CN 101036713 A CN101036713 A CN 101036713A CN 200610065789 CN200610065789 CN 200610065789 CN 200610065789 A CN200610065789 A CN 200610065789A CN 101036713 A CN101036713 A CN 101036713A
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Abstract
The invention relates to a Shubiton condensed pill and a preparing method therefor. The condensed pill is formed by the following materials based on weight ratio: 2000 gram armand clematis, 1000 gram uncaria, 1000 gram wild chrysanthemum, and 230 gram loosestrife, wherein the wild chrysanthemum calculated by linarin is more than 6.0 mg based on per gram of the product. The Shubiton condensed pill has fine and reliable curative effect, which has rapid improving effect of symptom of a benign prostatic hyperplasia patient, in particular has a remarkable reducing action of residual urine, thus quality of the patient life is improved; the preparing process is simple, and it is convenient for taking and carrying with good quality and reliable medicine; the invention maintains advantages of traditional medicine, has big profit margin and fine market prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Shumitong concentrated pill and preparation method thereof.
Background technology
Prostatitis is the commonly encountered diseases of male senile patient, its consequence is comparatively serious, and the clinical manifestation during morbidity has symptoms such as frequent micturition, urgent micturition, dysurea, dysuria, urine retention sense, urine retention, urinary incontinence, hematuria, urinary system infection, renal function injury, vesical calculus.Above symptom all belongs to the stranguria category of the traditional Chinese medical science.So application Chinese medicine, with heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, hard masses softening and resolving are the rule of treatment.
SHUMITONG JIAONANG is Yi nationality, distributed over Yunnan, Sichuan and Guizhou's medicine prescription, includes Caulis Clematidis Armandii, Ramulus Uncariae Cum Uncis, Flos Chrysanthemi Indici and Herba Lysimachiae.The doctor of Yi nationality thinks: Xi Fuse mile mile promise slave promise, and Fu Sakai slave, it is uncommon to tell soil, the female Ge Ji of sieve; The traditional Chinese medical science thinks that it has heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, the effect of hard masses softening and resolving.Be used for the difficulty in urination due to the damp-heat accumulation, the urine amount is few, and heat is red not well, and prostate hyperplasia is seen above-mentioned card marquis person.Whole prescription forward-backward correlation mutually replenishes, and has both strengthened the power of principal agent, each its merit of holding concurrently again, and all medicines share, and also clearly also rush down diuresis and do not flow heresy, and hard masses softening and resolving again.
Widely apply the Caulis Clematidis Armandii clearing away heat and promoting diuresis in the side, be used for edema, gonorrhea, urinary obstruction, arthralgia; Be aided with the Herba Lysimachiae eliminating damp-heat, treating stranguria, detumescence is used for pyretic stranguria, and husky the pouring urinated and puckeryly had a pain jaundice dark coloured urine, carbuncle furuncle, lithangiuria; Ramulus Uncariae Cum Uncis endogenous wind stopping relieving convulsion, the heat clearing away suppressing the hyperactive liver, it is dizzy to be used to have a headache, and infantile convulsion is twitched, vascular hypertension; The Flos Chrysanthemi Indici heat-clearing and toxic substances removing is used for the furuncle carbuncle, conjunctival congestion and swelling pain, and it is dizzy to have a headache.All medicines share, but heat-clearing and toxic substances removing just, inducing diuresis for treating stranguria syndrome, and reach hard masses softening and resolving.
Yet most flavour of a drug water is carried in the method for making of SHUMITONG JIAONANG, and extracting solution concentrates, and drying is beaten powder and all the other minority medical material fine powders and mixed, and is directly encapsulated, because extract powder accounts for to such an extent that ratio is very big, and the easy in process of production moisture absorption, environment is wayward.
Summary of the invention
The inventor is in order to improve stability of formulation, increase preparation variety, adapt to the different needs of extensive patients, simultaneously again because of advantages such as the production technology of pill are simple and direct, change the SHUMITONG JIAONANG agent into concentrated pill (pill that the concentrated back of part medicinal material extract and all the other medical material fine powders are made with water), and carried out relevant experimental study.This preparation is fit to the needs of disease and the character of medicine own, meets the requirement of official preparation general rule.
Lack the technological parameter that decocts the water yield in the preparation method of original capsule, the inventor is according to the physicochemical property of its composition, and by the paste-forming rate of water extraction and two indexs of linarin extraction ratio in the assay composition Flos Chrysanthemi Indici, the decoction amount of water has been investigated in refinement.In addition, technologies such as pulverizing, mixing, preparations shaping, drying have been carried out systematic study, obtained feasible technological parameter in detail, made the present invention in suitability for industrialized production, have more operability.
Shumitong concentrated pill is the concentrated pill of being processed into by Caulis Clematidis Armandii, Ramulus Uncariae Cum Uncis, Flos Chrysanthemi Indici, Herba Lysimachiae four flavor Chinese medicines and extract thereof, it is as national medicine, is mainly used in the difficulty in urination due to the treatment damp-heat accumulation, and the urine amount is few, heat is red not well, and prostate hyperplasia is seen above-mentioned card marquis person.
Technical scheme of the present invention is:
A kind of Shumitong concentrated pill, it comprises that following raw material makes by weight ratio:
Caulis Clematidis Armandii 2000g Ramulus Uncariae Cum Uncis 1000g Flos Chrysanthemi Indici 1000g Herba Lysimachiae 230g
The every gram of finished product contains Flos Chrysanthemi Indici and is no less than 6.0mg in linarin.
The preparation method of Shumitong concentrated pill of the present invention may further comprise the steps: above four flavors, and depletion money grass meal is broken into fine powder; Ramulus Uncariae Cum Uncis, Caulis Clematidis Armandii and Flos Chrysanthemi Indici three flavors are ground into coarse powder, add 6-10 times of water gaging and decoct three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter merging filtrate, be concentrated into the thick paste of 50 ℃ of following relative densities 1.35~1.40, be dried to dry extract, be ground into fine powder, with dry extract and Herba Lysimachiae fine powder mixing, add suitable quantity of water and make concentrated pill, the 500g finished product is made in the drying polishing.
Wherein: the raw material Flos Chrysanthemi Indici is pressed dry product and is calculated, and contains linarin (C
28H
32O
14) must not be less than 0.80%; The every gram of finished product contains Flos Chrysanthemi Indici with linarin (C
28H
32O
14) meter, be no less than 6.0mg.
Studies show that preparation method of the present invention is mature and stable, guaranteed that end product quality is reliable and stable.The pill outward appearance that the method is made is bright and clean attractive in appearance, and meets " every inspection that an appendix IA of Chinese pharmacopoeia version in 2005 pill is stipulated down.
Below be the preferred foundation of process conditions in the preparation method:
The pulverizing of Herba Lysimachiae
Herba Lysimachiae is ground into fine powder with Universalpulverizer, and fine powder is by " regulation in " note on the use " that Chinese pharmacopoeia version in 2005 is an one is meant all and sieves by No. five, and contain can be by 95% the powder of being no less than that sieves for No. six.
Three flavor extraction solvent consumptions such as Caulis Clematidis Armandii
The chemical constituent of below respectively distinguishing the flavor of in the medical material mostly is the glycoside composition and exists, and they mostly are water soluble ingredient greatly, so that water is carried is more complete.In the preparation method of original capsule, lack the technological parameter that decocts the water yield, therefore, the inventor during to three flavor decoctings such as Caulis Clematidis Armandii the parameter of amount of water investigate.
Composition with reference to assay in the former prescription is a Flos Chrysanthemi Indici, according to the modern pharmacy progress with " in one one of the Chinese pharmacopoeia version in 2005 to Flos Chrysanthemi Indici assay index, the inventor is when doing the decocting process investigation, two indexs of extraction ratio of extractum yield and linarin have been selected for use, wherein based on the linarin extraction ratio, with paste-forming rate is auxilliary, determines the amount of water that water is carried according to its yield.Found that, use the 6-10 times of water gaging decoction extractum yield and the linarin rate of transform all higher.Take all factors into consideration factors such as energy consumption, paste-forming rate, more preferably with 8 times of water gaging decocting herbs.
Concentrate
The condition of concentrating: adopt normal pressure to concentrate earlier, adopt vacuum concentration again, vacuum 0.06Kpa, temperature 70-80 ℃.Decocting liquid is concentrated into the thick paste that relative density is 1.35~1.40 (50 ℃).
Dry
For the drying process of extract, can adopt the normal pressure forced air drying, drying under reduced pressure or spray drying.Wherein normal pressure forced air drying temperature is 80 ℃; The drying under reduced pressure condition is 70~80 ℃, 0.08~0.09MPa; The spray drying condition is 100~110 ℃ of inlet temperature, 80~90 ℃ of leaving air temps.Wherein better with the moisture of spray drying and drying under reduced pressure and dissolubility effect.But because the easy moisture absorption of spray-dried powders, and yield lacks than drying under reduced pressure, so more preferably adopt drying under reduced pressure.
Facing-up mixes
Dry extract and described Herba Lysimachiae fine powder with the method facing-up that equivalent increases progressively, are sieved mixing.
Preparations shaping technology
With fine powder and dry extract mixing, machinery is moulded and is made ball, every ball control 0.2g.
1 amount of water is investigated
Because extractum and medical material powder are dried powder, prepare the method that concentrated pill is suitable for adopting the interpolation wetting agent, it is better that the inventor adopts water to prepare effect, and amount of water and mixed powder are than 1ml: pill forming during 5-10g.
2 dryings
Behind the pill, baking temperature is decided to be 70-80 ℃.
3 waxings
Dry good pill is waxed with Cera Chinensis.
Character
Finished product of the present invention is the concentrated pill of sepia to brownish black; Feeble QI, mildly bitter flavor.
Usage and dosage
Oral, a 5-10 ball, 3 times on the one.
Shumitong concentrated pill of the present invention has following characteristics: good effect and stable, and rapid to prostatic hyperplasia patient's doing well,improving effect, especially very remarkable to residual urine volume minimizing effect, improved quality of life of patient; Production technology is simple, take and easy to carry, quality assurance, medicine stable; Kept the traditional medicine characteristics, profit margin is big, good market prospects.
The specific embodiment
Illustrate Shumitong concentrated pill of the present invention and preparation method thereof below.
Embodiment 1:
Caulis Clematidis Armandii 2000g Ramulus Uncariae Cum Uncis 1000g Flos Chrysanthemi Indici 1000g Herba Lysimachiae 230g
More than four the flavor, depletion money grass meal is broken into fine powder; Ramulus Uncariae Cum Uncis, Caulis Clematidis Armandii and Flos Chrysanthemi Indici three flavors are ground into coarse powder, add 8 times of water gagings and decoct three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter, merging filtrate, be concentrated into the thick paste of 50 ℃ of following relative densities 1.35~1.40, drying under reduced pressure becomes dry extract, is ground into fine powder, with dry extract and Herba Lysimachiae fine powder mixing, (ratio of amount of water and mixed powder is 1ml: 8g), make concentrated pill, the 500g finished product is made in the drying polishing to add the water pill.After testing, the every gram of finished product contains Flos Chrysanthemi Indici and counts 9.12mg with linarin.
Claims (10)
1. Shumitong concentrated pill is characterized in that it comprises that following raw material makes by weight ratio:
Caulis Clematidis Armandii 2000g Ramulus Uncariae Cum Uncis 1000g Flos Chrysanthemi Indici 1000g Herba Lysimachiae 230g
The every gram of described concentrated pill finished product contains Flos Chrysanthemi Indici and is no less than 6.0mg in linarin.
2. Shumitong concentrated pill as claimed in claim 1 is characterized in that its preparation method comprises: above four flavors, and depletion money grass meal is broken into fine powder; Ramulus Uncariae Cum Uncis, Caulis Clematidis Armandii and Flos Chrysanthemi Indici three flavors are ground into coarse powder, add 6-10 times of water gaging and decoct three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter merging filtrate, be concentrated into the thick paste of 50 ℃ of following relative densities 1.35~1.40, be dried to dry extract, be ground into fine powder, with dry extract and Herba Lysimachiae fine powder mixing, add suitable quantity of water and make concentrated pill, the 500g finished product is made in the drying polishing.
3. the preparation method of a Shumitong concentrated pill as claimed in claim 1 is characterized in that may further comprise the steps: above four flavors, and depletion money grass meal is broken into fine powder; Ramulus Uncariae Cum Uncis, Caulis Clematidis Armandii and Flos Chrysanthemi Indici three flavors are ground into coarse powder, add 6-10 times of water gaging and decoct three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter merging filtrate, be concentrated into the thick paste of 50 ℃ of following relative densities 1.35~1.40, be dried to dry extract, be ground into fine powder, with dry extract and Herba Lysimachiae fine powder mixing, add suitable quantity of water and make concentrated pill, the 500g finished product is made in the drying polishing.
4. preparation method as claimed in claim 3 is characterized in that: the raw material Flos Chrysanthemi Indici is pressed dry product and is calculated, and contains linarin and must not be less than 0.80%.
5. as claim 3 or 4 described preparation methoies, it is characterized in that the condition that concentrates is: adopt normal pressure to concentrate earlier, adopt vacuum concentration again, vacuum 0.06Kpa, temperature 70-80 ℃.
6. as each described preparation method among the claim 3-5, it is characterized in that: the drying of described thick paste adopts drying under reduced pressure, 70~80 ℃ of temperature, pressure 0.08~0.09MPa.
7. as each described preparation method among the claim 3-6, it is characterized in that: described dry extract and described Herba Lysimachiae fine powder sieve mixing with the method facing-up that equivalent increases progressively.
8. as each described preparation method among the claim 3-7, it is characterized in that: the ratio of amount of water and mixed powder is 1ml: 5-10g during pill.
9. as each described preparation method among the claim 3-8, it is characterized in that: behind the pill, baking temperature is 70-80 ℃.
10. as each described preparation method among the claim 3-9, it is characterized in that: dry good pill is waxed with Cera Chinensis.
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CN 200610065789 CN101036713A (en) | 2006-03-16 | 2006-03-16 | Shumitong concentrated pill and the method for preparing the same |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102861302A (en) * | 2011-07-08 | 2013-01-09 | 余毅 | Traditional Chinese preparation for treating benign prostatic hyperplasia and preparation method for traditional Chinese preparation |
CN104666534A (en) * | 2015-02-14 | 2015-06-03 | 浙江大学 | Method for improving quality of Ganmaoling granule intermediates |
CN105012441A (en) * | 2015-07-07 | 2015-11-04 | 西安交通大学 | Application of uncaria active alkaloid to preparation of prostate medicaments |
CN108693296A (en) * | 2018-05-23 | 2018-10-23 | 云南中丹红制药有限责任公司 | SHUMITONG JIAONANG and its raw material detection method |
-
2006
- 2006-03-16 CN CN 200610065789 patent/CN101036713A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102861302A (en) * | 2011-07-08 | 2013-01-09 | 余毅 | Traditional Chinese preparation for treating benign prostatic hyperplasia and preparation method for traditional Chinese preparation |
CN102861302B (en) * | 2011-07-08 | 2014-05-07 | 余毅 | Traditional Chinese preparation for treating benign prostatic hyperplasia and preparation method for traditional Chinese preparation |
CN104666534A (en) * | 2015-02-14 | 2015-06-03 | 浙江大学 | Method for improving quality of Ganmaoling granule intermediates |
CN104666534B (en) * | 2015-02-14 | 2018-04-20 | 浙江大学 | A kind of method of weight among raising Ganmaoling Granules |
CN105012441A (en) * | 2015-07-07 | 2015-11-04 | 西安交通大学 | Application of uncaria active alkaloid to preparation of prostate medicaments |
CN108693296A (en) * | 2018-05-23 | 2018-10-23 | 云南中丹红制药有限责任公司 | SHUMITONG JIAONANG and its raw material detection method |
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Open date: 20070919 |