CN101036754A - Condensed pill for treating vertigo and the method for preparing the same - Google Patents
Condensed pill for treating vertigo and the method for preparing the same Download PDFInfo
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- CN101036754A CN101036754A CN 200610065787 CN200610065787A CN101036754A CN 101036754 A CN101036754 A CN 101036754A CN 200610065787 CN200610065787 CN 200610065787 CN 200610065787 A CN200610065787 A CN 200610065787A CN 101036754 A CN101036754 A CN 101036754A
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Abstract
The invention relates to a Pingxuan concentrated pill and preparation method thereof. The said concentrated pill is composed of 360g of crepis phoenix, 360g of aralia chinensis, 48g of polygonatum odoratum, 60g of gastrodia tuber, 60g of notoginseng, 240g of catchweed beastraw and 360g of agrimony by weight. The end product of the concentrated pill contains over 0.6mg of ginsenoside Rg1 per gram. The concentrated pill conquers the disadvantage of easily absorbing moisture of the original capsule, increases the stability and the variety of the preparation to make it easy to be carried about and convenient for production. The time of slaking is long, therefore the purpose of the slow and long-term treatment is obtained.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of condensed pill for treating vertigo and preparation method thereof.
Background technology
Dizziness is a kind of commonly encountered diseases of pilosity.
Flat dizzy capsule is an ethnic groups Yi nationality medical drugs, and Radix Crepidis Ligneae, Cortex araliae chinensis, Rhizoma Gastrodiae share the effect with the detoxifcation of dispeling the wind, suppressing the hyperactive liver to relieve the wind syndrome in the side, suppresses to disturb on the liver-yang, and treatment is had a dizzy spell, cardiopalmus tinnitus; Rhizoma Polygonati has effects such as boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying, but nourishing YIN and YANG hyperactivity suppressing; The hemostasis of becoming silted up of loosing of Cortex araliae chinensis, Radix Notoginseng, subduing swelling and relieving pain, hepatic and renal YIN deficiency and be not enough to carry the blood operation, blood is capable not smooth, is jammed into the stasis of blood, and two medicines can both be invigorated blood circulation, and inspire QI-blood circulation, and dissipation congestion makes the blood smoothness, and the beniol profit is then dizzy from disappearing; The Herba Galii Teneri heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, the effect of reducing swelling and alleviating pain, but removing heat from the liver; Herba Agrimoniae astringing to arrest bleeding, parasite killing, dysentery relieving etc.Whole prescription forward-backward correlation mutually replenishes, and has both strengthened the power of principal agent, each its merit of holding concurrently again, and all medicines share, but just nourishing liver and kidney, suppressing the hyperactive liver and subsiding YANG.Be used for deficiency of the liver and kindey, dizzy due to disturbing on the liver-yang, headache, cardiopalmus tinnitus, insomnia and dreamful sleep, diseases such as soreness of the waist and knees.
Most flavour of a drug water is carried in the flat dizzy capsule prescription, and extracting solution concentrates, and drying is beaten powder and all the other minority medical material fine powders and mixed, and is directly encapsulated, because the ratio that extract powder accounts for is very big, and the easy in process of production moisture absorption, environment is wayward.
Summary of the invention
In order to overcome the shortcoming of the easy moisture absorption of original capsule, improve stability of formulation, increase preparation variety, make the patient easy to carry, production technology because of pill is simple and direct again simultaneously, be convenient to produce, the inventor will put down dizzy capsule and change system into concentrated pill (being to mix the pill made from water with all the other medical material fine powders and dressing after the part medicinal material extract concentrates).This concentrated pill is fit to the needs of disease and the character of medicine own, meets the requirement of official preparation general rule.
Simultaneously, flat dizzy capsule institute at disease mostly be the deficient syndrome of saying in the traditional Chinese medical science, should take medicine for a long time, slowly reach control and treat the purpose of disease.The inventor finds in experiment, and the disintegration time of condensed pill for treating vertigo is slow, about 45 minutes to 1 hour, well imagines to have reached the dissolving of drug slow wherein slowly and the long periods of treatment purpose.
The more former method for making before the dosage changing form does not describe in detail for extraction process by water, and in the correlational study work of dosage changing form, the inventor is according to the physicochemical property of its composition, and by paste-forming rate and two indexs of n-butyl alcohol extractum of water extraction, the decoction amount of water has been investigated in refinement.In addition, the inventor has also carried out systematic study to technologies such as pulverizing, mixing, pill, dryings, especially the pharmaceutical preparation moulding process is studied, and has obtained detailed feasible technological parameter, makes the suitability for industrialized production of this technology have more operability.Result of study shows that the said preparation technical maturity is stable, has guaranteed that end product quality is reliable and stable.
Condensed pill for treating vertigo of the present invention comprises that following raw material makes by weight ratio:
Radix Crepidis Ligneae 360g Cortex araliae chinensis 360g Rhizoma Polygonati 48g Rhizoma Gastrodiae 60g
Radix Notoginseng 60g Herba Galii Teneri 240g Herba Agrimoniae 360g
The every gram of described concentrated pill finished product contains more than the ginsenoside Rg1 0.6mg.
The preparation method of condensed pill for treating vertigo of the present invention comprises: above seven flavors, and get Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder and be broken into fine powder, mixing, it is standby to sterilize; All the other Radix Crepidis Ligneae, Cortex araliae chinensis, Herba Galii Teneri and Herba Agrimoniae four flavors add 6-10 times of water gaging and decoct three times, add 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, merging filtrate, leave standstill, get supernatant concentration, be dried to fine powder to relative density 1.10～1.15 (60 ℃) thick paste of (being equivalent to 1.11-1.16 (50 ℃)), the dry extract that obtains is mixed with the fine powder that Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder are broken into, it is an amount of to add starch, and mixing is made concentrated pill 500g with suitable quantity of water.
The pill outward appearance that the present invention makes is bright and clean attractive in appearance, and meets " every inspection that an appendix IA of Chinese pharmacopoeia version in 2005 pill is stipulated down.
Below be the preferred foundation of process conditions in the preparation method:
The pulverizing of Rhizoma Polygonati, Rhizoma Gastrodiae, Radix Notoginseng
With Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng are ground into fine powder with Universalpulverizer, and fine powder is by " regulation in " note on the use " that Chinese pharmacopoeia version in 2005 is an one is meant all and sieves by No. five, and contain can be by 95% the powder of being no less than that sieves for No. six.
Four flavor extraction solvent consumptions such as Radix Crepidis Ligneae
Former decocting process is existing to decoct number of times and decocting time, but lacks the technological parameter that decocts the water yield.The parameter of amount of water was investigated when therefore, the inventor was to four flavor decoctings such as Radix Crepidis Ligneaes.Found that use 6-10 times of water gaging decocting herbs, extractum yield and n-butyl alcohol extractum yield are all higher.
Dry
For the drying process of extract, can adopt normal pressure forced air drying, drying under reduced pressure and spray drying.Wherein normal pressure forced air drying temperature is 80 ℃; The drying under reduced pressure condition is 80 ℃, 0.08～0.09MPa; The spray drying condition is 100～110 ℃ of inlet temperature, 80～90 ℃ of leaving air temps.And with spray-dired moisture best with the dissolubility effect.
Concentrate
1, concentrates condition
Adopt normal pressure to concentrate earlier, adopt vacuum concentration again, condition is vacuum 0.06Kpa, temperature 70-80 ℃.
2, concentrate density
Dried cream yield height when concentrated density is controlled at 1.10～1.15 (60 ℃).Select spray drying for use as drying means, then concentrating density can be lower, has also saved energy consumption thus.
Facing-up mixes
The fine powder that dry extract and Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder are broken into sieves mixing with the method facing-up that equivalent increases progressively.
Preparations shaping technology
With fine powder and dry extract mixing, machinery is moulded and is made ball, and every ball is controlled at 0.2g.
1, adjuvant
Because the flavour of a drug of extracting in water are more in this prescription, fluid extract after causing it to extract is many, in pelletizing process, find, medical material is sneaked in dry extract, its state is than thickness after adding water, and easy-formation does not consider that adding appropriate amount of auxiliary materials helps molding in principal agent, and it is cheap and have certain disintegrative and absorptive adjuvant kind starch and addition thereof finally to have established price, draws better molding prescription at last.The weight proportion that is starch and principal agent powder is 1: 5-10, wherein the principal agent powder is that the dry extract that Radix Crepidis Ligneae, Cortex araliae chinensis, Herba Galii Teneri and Herba Agrimoniae four flavors obtain mixes the medicated powder that obtains with the fine powder that Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder are broken into.
2, amount of water
The proportioning 1ml of amount of water and mixed powder: pill forming during 5-10g, wherein mixed powder is that starch mixes the medicated powder that obtains with above-mentioned principal agent powder.
3, drying
Behind the pill, baking temperature is decided to be 70-80 ℃.
4, waxing
Dry good pill is waxed with Cera Chinensis.
Character
Condensed pill for treating vertigo of the present invention is the concentrated pill of sepia to brownish black; Gas perfume (or spice), mildly bitter flavor.
Usage and dosage
Oral, a 5-10 ball, 3 times on the one.
Condensed pill for treating vertigo of the present invention has following characteristics: 1, obviously improve symptom, human body immunity improving power, improved quality of life of patient; 2, production technology simple, take and easy to carry, quality assurance, medicine stable; 3, kept the traditional medicine characteristics, profit margin is big, good market prospects.
The specific embodiment
Illustrate condensed pill for treating vertigo of the present invention and preparation method thereof below.
Embodiment 1:
Radix Crepidis Ligneae 360g; Cortex araliae chinensis 360g; Rhizoma Polygonati 48g; Rhizoma Gastrodiae 60g; Radix Notoginseng 60g; Herba Galii Teneri 240g; Herba Agrimoniae 360g.More than seven the flavor, get Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder and be broken into fine powder, mixing, it is standby to sterilize; All the other Radix Crepidis Ligneae, Cortex araliae chinensis, Herba Galii Teneri and Herba Agrimoniae four flavors, adding 8 times of water gagings decocts three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filters, merging filtrate, leave standstill, get the thick paste of supernatant concentration, be spray dried to fine powder to relative density 1.10～1.15 (60 ℃), the dry extract that obtains is mixed with the fine powder that Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder are broken into, add starch (weight proportion of starch and principal agent powder is 1: 7), mixing, (proportioning of water and mixed powder is 1ml: 6g) make concentrated pill 500g with water.The every gram of finished product contains ginsenoside Rg1 4.18mg.
Claims (10)
1. condensed pill for treating vertigo is characterized in that it comprises that following raw material makes by weight ratio:
Radix Crepidis Ligneae 360g Cortex araliae chinensis 360g Rhizoma Polygonati 48g Rhizoma Gastrodiae 60g
Radix Notoginseng 60g Herba Galii Teneri 240g Herba Agrimoniae 360g
The every gram of described concentrated pill finished product contains more than the ginsenoside Rg1 0.6mg.
2. condensed pill for treating vertigo as claimed in claim 1 is characterized in that its preparation method comprises: gets Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder and is broken into fine powder, and mixing, it is standby to sterilize; All the other Radix Crepidis Ligneae, Cortex araliae chinensis, Herba Galii Teneri and Herba Agrimoniae four flavors add 6-10 times of water gaging and decoct three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, merging filtrate, leave standstill, get supernatant concentration to 60 ℃ following relative density and be 1.10～1.15 thick paste, be dried to fine powder, the dry extract that obtains is mixed with the fine powder that Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder are broken into, it is an amount of to add starch, and mixing is made concentrated pill 500g with suitable quantity of water.
3. the preparation method of a condensed pill for treating vertigo as claimed in claim 1 is characterized in that may further comprise the steps: gets Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder and is broken into fine powder, and mixing, it is standby to sterilize; All the other Radix Crepidis Ligneae, Cortex araliae chinensis, Herba Galii Teneri and Herba Agrimoniae four flavors, 6-10 times of water gaging decocts three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, merging filtrate, leave standstill, get supernatant concentration to 60 ℃ following relative density and be 1.10～1.15 thick paste, be dried to fine powder, the dry extract that obtains is mixed with the fine powder that Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder are broken into, it is an amount of to add starch, and mixing is made concentrated pill 500g with suitable quantity of water.
4. preparation method as claimed in claim 3 is characterized in that: the dry spray drying that adopts, and inlet temperature is 100～110 ℃, leaving air temp is 80～90 ℃.
5. as claim 3 or 4 described preparation methoies, it is characterized in that: the condition that concentrates concentrates for adopting normal pressure earlier, adopts vacuum concentration again, and vacuum is 0.06Kpa, and temperature is 70-80 ℃.
6. as each described preparation method among the claim 3-5, it is characterized in that: described dry extract mixes with the method facing-up that equivalent increases progressively with the fine powder that described Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder are broken into.
7. as each described preparation method among the claim 3-6, it is characterized in that: the weight proportion of starch and principal agent powder is 1: 5-10, wherein the principal agent powder is that the dry extract that Radix Crepidis Ligneae, Cortex araliae chinensis, Herba Galii Teneri and Herba Agrimoniae four flavors obtain mixes the medicated powder that obtains with the fine powder that Rhizoma Polygonati, Rhizoma Gastrodiae and Radix Notoginseng powder are broken into.
8. preparation method as claimed in claim 7 is characterized in that: the proportioning of water and mixed powder is 1ml: 5-10g during molding, and wherein mixed powder is that starch mixes the medicated powder that obtains with above-mentioned principal agent powder.
9. as each described preparation method among the claim 3-8, it is characterized in that: the baking temperature behind the pill is 70-80 ℃.
10. preparation method as claimed in claim 9 is characterized in that: dry good pill is waxed with Cera Chinensis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610065787 CN101036754A (en) | 2006-03-16 | 2006-03-16 | Condensed pill for treating vertigo and the method for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610065787 CN101036754A (en) | 2006-03-16 | 2006-03-16 | Condensed pill for treating vertigo and the method for preparing the same |
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| Publication Number | Publication Date |
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| CN101036754A true CN101036754A (en) | 2007-09-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200610065787 Pending CN101036754A (en) | 2006-03-16 | 2006-03-16 | Condensed pill for treating vertigo and the method for preparing the same |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406846A (en) * | 2011-11-28 | 2012-04-11 | 卞毓平 | Application of Pingxuan capsule in preparing medicine capable of treating vasculitis |
| CN105232784A (en) * | 2015-11-20 | 2016-01-13 | 宋大鲁 | Traditional Chinese medicine for treating tinnitus |
| CN110302274A (en) * | 2019-07-30 | 2019-10-08 | 数源汇通（北京）医药科技有限公司 | Alleviate the Traditional Chinese drug mixture and preparation method thereof of stomach disease |
-
2006
- 2006-03-16 CN CN 200610065787 patent/CN101036754A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406846A (en) * | 2011-11-28 | 2012-04-11 | 卞毓平 | Application of Pingxuan capsule in preparing medicine capable of treating vasculitis |
| CN105232784A (en) * | 2015-11-20 | 2016-01-13 | 宋大鲁 | Traditional Chinese medicine for treating tinnitus |
| CN110302274A (en) * | 2019-07-30 | 2019-10-08 | 数源汇通（北京）医药科技有限公司 | Alleviate the Traditional Chinese drug mixture and preparation method thereof of stomach disease |
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