CN104107325A - Medicinal composition with effect of improving memory and preparation method of medicinal composition - Google Patents
Medicinal composition with effect of improving memory and preparation method of medicinal composition Download PDFInfo
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Abstract
The invention belongs to the technology of traditional Chinese medicinal preparations and the technical field of healthy foods, and particularly relates to a medicinal composition with an effect of improving memory and a preparation method of the medicinal composition. The medicinal composition is prepared by compatibility of the following raw medicinal materials: ginkgo leaf, polygala tenuifolia, lucid ganoderma, polygonatum kingianum and fructus lycii, which has the effects of tonifying qi and tranquilizing, activating blood circulation to remove stasis and tonifying liver and kidney and the raw medicinal materials can together exert the function of improving memory.
Description
Technical field
The invention belongs to pharmaceutical preparation and health food, food technology field, be specifically related to a kind of pharmaceutical composition of improving memory effect and preparation method thereof that has.
Background technology
Memory refers to draws the fresh information that obtains from surrounding or experience, knowledge specific part symbolization, storage at brain by it of study, then the process of recalling.Multiple stages that the process of memory is divided into absorption, symbolization, strengthens, maintains, recalls.Along with modern society is complicated, specialized development trend, need to obtain bulk information and study, and along with the prolongation of human longevity requires the ergasia of height more gradually, therefore brain needs effectively motion.But modern many people are because the dysmnesia that aging and disease cause cause the inconvenience in work, studying and living.
Dysmnesia (Impaired Memory), refer to that individual can not remember or the state of memory information or technical ability in a kind of, be likely the permanent or temporary dysmnesia that cause due to reason Pathophysiology or situation, wherein temporary dysmnesia are medically called again amnesia.Human memory's obstacle is an important medical science and Psychologic Problems.This phenomenon all has and occurs and the sickness rate trend that becomes younger at mankind's all age group, comprises the retarded and childhood hyperkinetic syndrome of the children's of Childhood; Adolescence's dysmnesia are mainly dyslexia, dysmnesia; Old dysmnesia main manifestations is various types of dementias.Dysmnesia can be divided into organic and functional two large classes, and organic dysmnesia are mainly to cause due to the organic disease of health or wound reason, comprise the cerebral tumor, cerebral trauma, encephalitis, apoplexy etc., cause hypomnesis or forfeiture; Some chronic disease, as endocrine dysfunction, malnutrition, chronic poisoning, arteriosclerosis, cervical spondylosis etc., also can damage brain and cause learning memory disorder.Functional dysmnesia are mainly manifested in: age growth, and hobby tobacco and wine, life, the large initiation psychological problems of operating pressure, absorption undernutrition etc. causes learning memory disorder.Mostly children's learning memory disorder is that this class crowd is very many because pressure and nutrition cause, according to World Health Organization's statistics, the amnemonic number ratio of Global Learning, about 1-3%, calculates accordingly, and China patient is greatly about more than 1,000 ten thousand.So numerous patients, will be serious Medicine and society's problem.Carried out multiple effort in order well to tackle this situation people, what be for example necessary carries out ergasia so that brain is clear, promote memory, and is necessary to develop medicine or the functional food etc. that can effectively improve memory.Chinese medicine prevention disease is gone through the clinical practice of thousands of years, has accumulated rich experience, has formed unique theory and method, has good clinical effectiveness.Chinese medicine has feature natural, efficient, low toxicity for improving learning and memory, is one of focus of recent domestic research.For this reason, the present invention, according to the traditional Chinese medical science and modern pharmacology, provides a kind of pharmaceutical composition that improves memory effect that has.
Summary of the invention
For this reason, technical problem to be solved by this invention is to provide a kind of pharmaceutical composition of improving memory effect and preparation method thereof that has.
For solving the problems of the technologies described above, the invention provides a kind of pharmaceutical composition that improves memory effect that has, the crude drug of described pharmaceutical composition consists of: Folium Ginkgo 10-20 weight portion, Radix Polygalae 10-20 weight portion, Ganoderma 10-20 weight portion, Rhizoma Polygonati 10-20 weight portion and Fructus Lycii 10-20 weight portion.
Further, the crude drug of described pharmaceutical composition consists of: Folium Ginkgo 20 weight portions, Radix Polygalae 15 weight portions, Ganoderma 15 weight portions, Rhizoma Polygonati 15 weight portions and Fructus Lycii 15 weight portions.
The present invention also provides a kind of method of preparing aforementioned pharmaceutical compositions, comprises the steps:
(1) take Folium Ginkgo according to selected parts by weight and pulverize, add alcohol reflux, reclaim ethanol, concentrated, obtain alcohol extraction concentrated solution;
(2) take Radix Polygalae, Ganoderma, Rhizoma Polygonati and Fructus Lycii according to selected parts by weight, add purified water extraction, filter gained extracting solution, concentrated, obtain water extracting liquid;
(3) merge above-mentioned alcohol extraction concentrated solution and water extracting liquid, require suitably to concentrate, and add conventional adjuvant according to preparation, technique is made acceptable dosage form clinically routinely.
Further, described preparation method comprises the steps:
(1) get Folium Ginkgo according to selected parts by weight and pulverize, add the 40%-80% ethanol of 6-12 times of weight amount, 60 DEG C of-80 DEG C of reflux, extract, 1-3 time, each 1-4 hour, filters merge extractive liquid,, reclaim ethanol, while being concentrated into 70 DEG C, relative density is 1.03-1.10, obtains alcohol extraction concentrated solution;
(2) take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii according to selected parts by weight, add 6-10 times of weight amount purified water extraction 1-3 time, each 1-3 hour, filter, merge extractive liquid,, while being evaporated to 70 DEG C, relative density is 1.05-1.15, obtains water extracting liquid;
(3) merge above-mentioned alcohol extraction concentrated solution and water extracting liquid, while continuing to be concentrated into 70 DEG C, relative density is 1.15-1.25, by gained concentrated solution and conventional adjuvant routinely technique make acceptable dosage form clinically.
Further, described preparation method comprises the steps:
(1) getting Folium Ginkgo according to selected parts by weight pulverizes, 60 DEG C of reflux, extract, 2 times, add for the first time 10 times of weight amount 70% ethanol extraction 4 hours, add for the second time 8 times of weight amount 70% ethanol extraction 3 hours, filter, merge extractive liquid,, reclaims ethanol, while being concentrated into 70 DEG C, relative density is 1.03, obtains alcohol extraction concentrated solution;
(2) take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii according to selected parts by weight, add purified water extraction 2 times, adding for the first time 10 times of weight water gagings extracts 1 hour, adding for the second time 8 times of weight water gagings extracts 1 hour, filter, merge extractive liquid,, while being evaporated to 70 DEG C, relative density is 1.05, obtains water extracting liquid;
(3) merge above-mentioned alcohol extraction concentrated solution and water extracting liquid, while continuing to be concentrated into 70 DEG C, relative density is 1.15, adds conventional adjuvant, makes acceptable dosage form clinically according to conventional method.
The present invention also provides another to have the pharmaceutical composition that improves memory effect, and described drug regimen raw material consists of: Folium Ginkgo extract 1-3 weight portion, Radix Polygalae 10-20 weight portion, Ganoderma 10-20 weight portion, Rhizoma Polygonati 10-20 weight portion and Fructus Lycii 10-20 weight portion.
Preferably, the crude drug of described pharmaceutical composition consists of: Folium Ginkgo extract 3 weight portions, Radix Polygalae 15 weight portions, Ganoderma 20 weight portions, Rhizoma Polygonati 10 weight portions and Fructus Lycii 15 weight portions.
The present invention also provides a kind of method of preparing above-mentioned pharmaceutical composition, comprises the steps:
(1) take Radix Polygalae, Ganoderma, Rhizoma Polygonati and Fructus Lycii according to selected parts by weight, add purified water extraction, filter and extracting solution is concentrated, obtain water extracting liquid or make dry extract;
(2) by above-mentioned water extracting liquid or dry extract, add Folium Ginkgo extract, add conventional adjuvant, technique is made acceptable dosage form clinically routinely.
Further, described preparation method comprises the steps:
(1) take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii according to selected parts by weight, add 6-10 times of weight amount purified water extraction 1-3 time, each 1-3 hour, extracting liquid filtering, merging filtrate, while being evaporated to 70 DEG C, relative density is 1.05-1.15, obtains concentrated solution, or is dried, pulverizes and to obtain dry extract;
(2) above-mentioned concentrated solution or dry extract are added to Folium Ginkgo extract, add conventional adjuvant routinely technique make acceptable dosage form clinically.
Preferably, described preparation method comprises the steps:
(1) take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii according to selected parts by weight, add purified water extraction 2 times, adding for the first time 10 times of weight water gagings extracts 1 hour, adding for the second time 8 times of weight water gagings extracts 1 hour, extracting liquid filtering, merging filtrate, while being evaporated to 70 DEG C, relative density is 1.10, obtains concentrated solution;
(2) above-mentioned concentrated solution is added appropriate amount of auxiliary materials spraying dry, obtain spraying dry powder, the dry powder of spraying is mixed homogeneously with Folium Ginkgo extract, and subpackage, to obtain final product.
Wherein, described Folium Ginkgo extract prepares by the following method: get Folium Ginkgo and pulverize, add the ethanol of 6-12 times of weight amount 40%-80%, in 60 DEG C of-80 DEG C of reflux, extract, 1-3 time, each 1-4 hour, filter, merge extractive liquid, reclaim ethanol, by macroporous adsorbent resin on extracting solution, cross post with purified water and 10%-30% ethanol and remove impurity, then use 40-80% ethanol elution, collect eluent, concentrating under reduced pressure obtains dry extract, and dry extract is added to 60 DEG C of-80 DEG C of reflux, extract, of 95% ethanol, filter extracting solution, concentrating under reduced pressure obtains dry extract, pulverize, obtain.
The invention also discloses and a kind ofly add conventional adjuvant by above-mentioned pharmaceutical composition, the pharmaceutical preparation of making according to common process or health food, food.
Described preparation, includes but not limited to granule, capsule, tablet, mixture, pill, syrup, electuary, medicated wine, tincture, soft extract, powder, injection, oral liquid, solid beverage, liquid beverage or bakes and banks up with earth food.
The invention also discloses described pharmaceutical composition and there is the purposes in medicine, health food or the food that improves memory effect in preparation.
Pharmaceutical composition Main Basis Chinese medical theory of the present invention, Folium Ginkgo extract blood circulation promoting and blood stasis dispelling in prescription, removing obstruction in the collateral to relieve pain, change turbid blood fat reducing, the Radix Polygalae Fructus Alpiniae Oxyphyllae of calming the nerves, restoring normal coordination between the heart and kidney, Ganoderma invigorating QI and tranquilization, Rhizoma Polygonati boosting qi and nourishing yin, kidney tonifying, Fructus Lycii nourishing the liver and kidney, benefit essence, by by above material combination application, there is effect of invigorating QI and tranquilization, blood circulation promoting and blood stasis dispelling, liver and kidney tonifying, common performance improves the function of memory.
Experimental example
Tested material is following according to the granule of filling a prescription in embodiment 1, prepared by technique.Press the principle of voluntariness and select 18-55 year experimenter 60 examples.Adopt before and after self reply according to and group between contrast two kinds of forms.60 experimenters are divided into test group and matched group at random, and test group is taken tested material, and matched group is taken the idle effect placebo of identical character.Each serving with 1 bag, every day 2 times, dose is 12g/ day, and continuous 45 days, experimenter cut out medicine or other health product relevant with improving memory during test-meal, does not participate in this and tests irrelevant memory quotient or IQ test.
Before and after taking, adopt the test of Clinical Memory scale, look into scale score with original point of the each subtest after test, each subtest scale score is added and obtains always scale score, looks into memory quotient with total scale score.Measure respectively and point to that memory, learning by association, random shape are re-recognized, image is freed recall and the association of portrait feature according to sequencing.Take every memory index situation of change of before and after test group and matched group in table 1.
The every memory index of table 1 is taken front and back situation of change
Note: * and matched group be P<0.05 relatively, and * * and matched group be P<0.01 relatively,
#with P<0.05 relatively before self test-meal,
##with relatively P<0.01 of matched group
From table 1, take every memory index scale no significant difference of before and after test group, matched group.Test group is taken rear every memory index scale and is taken front comparison, and difference all has significance (P<0.05), points to memory and extremely significantly (P<0.01) of portrait feature contact scale difference.Except random shape is re-recognized, other memory index scale of test group, with matched group comparison, difference has has significance (P<0.05), points to memory and extremely significantly (P<0.01) of portrait feature contact scale difference.More than illustrate that pharmaceutical composition of the present invention has the effect of good improvement memory.
Detailed description of the invention
Embodiment 1 granule
[prescription] Folium Ginkgo 20kg, Radix Polygalae 15kg, Ganoderma 15kg, Rhizoma Polygonati 15kg and Fructus Lycii 15kg.
It is broken that [preparation method] measures ginkgo leaf powder by prescription, and 60 DEG C of reflux, extract, 2 times, add 10 times of amount 70% ethanol extractions 4 hours for the first time, add for the second time 8 times of amount 70% ethanol extractions 3 hours, filter merge extractive liquid,, reclaim ethanol, being concentrated into relative density is 1.03 (70 DEG C of surveys).Take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii by recipe quantity, add purified water extraction 2 times, adding for the first time 10 times of water gagings extracts 1 hour, adding for the second time 8 times of water gagings extracts 1 hour, filter, merge extractive liquid,, being evaporated to relative density is 1.05 (70 DEG C of surveys), merge alcohol extraction concentrated solution and water extracting liquid, continuing to be concentrated into relative density is 1.15 (70 DEG C of surveys).By above-mentioned concentrated solution and appropriate conventional adjuvant and correctives stirring and evenly mixing, make soft material and cross 16 mesh sieve extruding granulations, dry, granulate, subpackage, to obtain final product.
Embodiment 2 tablets
[prescription] Folium Ginkgo 15 weight portions, Radix Polygalae 20 weight portions, Ganoderma 10 weight portions, Rhizoma Polygonati 20 weight portions and Fructus Lycii 10 weight portions.
It is broken that [preparation method] measures ginkgo leaf powder by prescription, and 70 DEG C of reflux, extract, 2 times, add 8 times of amount 60% ethanol extractions 3 hours for the first time, add for the second time 8 times of amount 60% ethanol extractions 1 hour, filter merge extractive liquid,, reclaim ethanol, being concentrated into relative density is 1.05 (70 DEG C of surveys).Take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii by recipe quantity, add purified water extraction 2 times, adding for the first time 8 times of water gagings extracts 2 hours, adding for the second time 6 times of water gagings extracts 1 hour, filter, merge extractive liquid,, being evaporated to relative density is 1.08 (70 DEG C of surveys), merge alcohol extraction concentrated solution and water extracting liquid, continuing to be concentrated into relative density is 1.20 (70 DEG C of surveys).Above-mentioned concentrated solution is mixed homogeneously with appropriate conventional adjuvant, add 50% ethanol high speed wet granulation, dry, granulate, tabletting, to obtain final product.
Embodiment 3 capsules
[prescription] Folium Ginkgo 20 weight portions, Radix Polygalae 10 weight portions, Ganoderma 15 weight portions, Rhizoma Polygonati 15 weight portions and Fructus Lycii 15 weight portions.
It is broken that [preparation method] measures ginkgo leaf powder by prescription, 80 DEG C of reflux, extract, 3 times, add for the first time 12 times of amount 50% ethanol extractions 2 hours, add for the second time 8 times of amount 50% ethanol extractions 1 hour, add for the third time 6 times of amount 50% ethanol extractions 1 hour, filter merge extractive liquid,, reclaim ethanol, being concentrated into relative density is 1.08 (70 DEG C of surveys).Take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii by recipe quantity, add purified water extraction 3 times, adding for the first time 8 times of water gagings extracts 1 hour, add for the second time 6 times of water gagings and extract 1 hour, add for the third time 6 times of water gagings and extract 1 hour, filter, merge extractive liquid,, being evaporated to relative density is 1.10 (70 DEG C of surveys), merges alcohol extraction concentrated solution and water extracting liquid, and continuing to be concentrated into relative density is 1.25 (70 DEG C of surveys).Above-mentioned concentrated solution is added to appropriate amount of auxiliary materials mix homogeneously, and spraying is dry, and dry-pressing is granulated, and filled capsules, to obtain final product.
Embodiment 4 mixture
[prescription] Folium Ginkgo 10 weight portions, Radix Polygalae 15 weight portions, Ganoderma 20 weight portions, Rhizoma Polygonati 10 weight portions and Fructus Lycii 20 weight portions.
It is broken that [preparation method] measures ginkgo leaf powder by prescription, adds 60 DEG C of reflux, extract, of 12 times of amount 70% ethanol 1 time, filters, and reclaims ethanol, and being concentrated into relative density is 1.10 (70 DEG C of surveys).Take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii by recipe quantity, add purified water extraction 3 times, add for the first time 8 times of water gagings and extract 1 hour, add for the second time 6 times of water gagings and extract 1 hour, add for the third time 6 times of water gagings and extract 1 hour, filter, merge extractive liquid,, being evaporated to relative density is 1.10 (70 DEG C of surveys), merges alcohol extraction concentrated solution and water extracting liquid, add appropriate correctives and antiseptic, adding water and adjusting medicinal liquid total weight parts is 150.Fill, sterilizing, to obtain final product.
Embodiment 5 solid beverages
[prescription] Folium Ginkgo extract 3 weight portions, Radix Polygalae 15 weight portions, Ganoderma 20 weight portions, Rhizoma Polygonati 10 weight portions and Fructus Lycii 15 weight portions.Described Folium Ginkgo extract is commercially available prod.
[preparation method] takes Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii by recipe quantity, add purified water extraction 2 times, adding for the first time 10 times of water gagings extracts 1 hour, adding for the second time 8 times of water gagings extracts 1 hour, extracting liquid filtering, merging filtrate, being evaporated to relative density is 1.10 (70 DEG C of surveys), obtains concentrated solution.Add appropriate amount of auxiliary materials spraying dry above-mentioned concentrated solution, obtain spraying dry powder, the dry powder of spraying is mixed homogeneously with Folium Ginkgo extract, and subpackage, to obtain final product.
Embodiment 6 liquid beverages
[prescription] Folium Ginkgo extract 2 weight portions, Radix Polygalae 20 weight portions, Ganoderma 10 weight portions, Rhizoma Polygonati 15 weight portions and Fructus Lycii 20 weight portions.
Described Folium Ginkgo extract obtains as follows: get Folium Ginkgo and pulverize, add the ethanol of 12 times of weight amounts 40%, in 80 DEG C of reflux, extract, 1 time, each 3 hours, filter merge extractive liquid,, reclaim ethanol, by macroporous adsorbent resin on extracting solution, cross post with purified water and 30% ethanol and remove impurity, then use 40% ethanol elution, collect eluent, concentrating under reduced pressure obtains dry extract, and dry extract is added to 60 DEG C of reflux, extract, of 95% ethanol, and filtering extracting solution, concentrating under reduced pressure obtains dry extract, pulverize, to obtain final product.
[preparation method] takes Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii by recipe quantity, add purified water extraction 3 times, adding for the first time 8 times of water gagings extracts 1 hour, adding for the second time 6 times of water gagings extracts 1 hour, add for the third time 6 times of water gagings and extract 1 hour, extracting liquid filtering, merging filtrate, being evaporated to relative density is 1.05 (70 DEG C of surveys), obtains concentrated solution.Above-mentioned concentrated solution is added to Folium Ginkgo extract and appropriate correctives, antiseptic mix homogeneously, and adjusting liquid total weight parts is 150, fill, and sterilizing, to obtain final product.Embodiment 7 pressed candies
[prescription] Folium Ginkgo extract 1 weight portion, Radix Polygalae 10 weight portions, Ganoderma 15 weight portions, Rhizoma Polygonati 20 weight portions and Fructus Lycii 10 weight portions.
Described Folium Ginkgo extract obtains as follows: get Folium Ginkgo and pulverize, add the ethanol of 9 times of weight amounts 60%, in 70 DEG C of reflux, extract, 2 times, each 2 hours, filter merge extractive liquid,, reclaim ethanol, by macroporous adsorbent resin on extracting solution, cross post with purified water and 20% ethanol and remove impurity, then use 60% ethanol elution, collect eluent, concentrating under reduced pressure obtains dry extract, and dry extract is added to 70 DEG C of reflux, extract, of 95% ethanol, and filtering extracting solution, concentrating under reduced pressure obtains dry extract, pulverize, to obtain final product.
[preparation method] takes Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii by recipe quantity, adds 10 times of amount purified water extraction 3 hours, extracting liquid filtering, and being evaporated to relative density is 1.02 (70 DEG C of surveys), obtains concentrated solution.By concentrated solution drying under reduced pressure, pulverize, obtain dry extract.By dry extract, Folium Ginkgo extract and Icing Sugar mix homogeneously, high speed wet granulation, granulate, 60 DEG C are dry, and tabletting, to obtain final product.
Obviously, above-described embodiment is only for example is clearly described, and the not restriction to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here without also giving exhaustive to all embodiments.And the apparent variation of being extended out thus or variation are still among the protection domain in the invention.
Claims (12)
1. one kind has the pharmaceutical composition that improves memory effect, it is characterized in that, the crude drug of described pharmaceutical composition consists of: Folium Ginkgo 10-20 weight portion, Radix Polygalae 10-20 weight portion, Ganoderma 10-20 weight portion, Rhizoma Polygonati 10-20 weight portion and Fructus Lycii 10-20 weight portion.
2. pharmaceutical composition according to claim 1, is characterized in that, the crude drug of described pharmaceutical composition consists of: Folium Ginkgo 20 weight portions, Radix Polygalae 15 weight portions, Ganoderma 15 weight portions, Rhizoma Polygonati 15 weight portions and Fructus Lycii 15 weight portions.
3. a method of preparing pharmaceutical composition described in claim 1 or 2, is characterized in that, comprises the steps:
(1) take Folium Ginkgo according to selected parts by weight and pulverize, add alcohol reflux, reclaim ethanol, concentrated, obtain alcohol extraction concentrated solution;
(2) take Radix Polygalae, Ganoderma, Rhizoma Polygonati and Fructus Lycii according to selected parts by weight, add purified water extraction, filter gained extracting solution, concentrated, obtain water extracting liquid;
(3) merge above-mentioned alcohol extraction concentrated solution and water extracting liquid, require suitably to concentrate, and add conventional adjuvant according to preparation, technique is made acceptable dosage form clinically routinely.
4. according to preparation method claimed in claim 3, it is characterized in that, comprise the steps:
(1) take Folium Ginkgo according to selected parts by weight and pulverize, add 6-12 and doubly measure 40%-80% ethanol, 60 DEG C of-80 DEG C of reflux, extract, 1-3 time, each 1-4 hour, filters merge extractive liquid,, reclaim ethanol, being concentrated into relative density at 70 DEG C is 1.03-1.10, obtains alcohol extraction concentrated solution;
(2) take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii according to selected parts by weight, add 6-10 doubly to measure purified water extraction 1-3 time, each 1-3 hour, filters, merge extractive liquid,, and being evaporated to relative density at 70 DEG C is 1.05-1.15, obtains water extracting liquid;
(3) merge alcohol extraction concentrated solution and water extracting liquid, while continuing to be concentrated into 70 DEG C, relative density is 1.15-1.25, by gained concentrated solution and conventional adjuvant routinely technique make acceptable dosage form clinically.
5. one kind has the pharmaceutical composition that improves memory effect, it is characterized in that, described drug regimen raw material consists of: Folium Ginkgo extract 1-3 weight portion, Radix Polygalae 10-20 weight portion, Ganoderma 10-20 weight portion, Rhizoma Polygonati 10-20 weight portion and Fructus Lycii 10-20 weight portion.
6. pharmaceutical composition according to claim 5, is characterized in that, the crude drug of described pharmaceutical composition consists of: Folium Ginkgo extract 3 weight portions, Radix Polygalae 15 weight portions, Ganoderma 20 weight portions, Rhizoma Polygonati 10 weight portions and Fructus Lycii 15 weight portions.
7. a method of preparing the pharmaceutical composition described in claim 5 or 6, is characterized in that, comprises the steps:
(1) take Radix Polygalae, Ganoderma, Rhizoma Polygonati and Fructus Lycii according to selected parts by weight, add purified water extraction, filter and extracting solution is concentrated, obtain water extracting liquid or make dry extract;
(2) by above-mentioned water extracting liquid or dry extract, add Folium Ginkgo extract, add conventional adjuvant, technique is made acceptable dosage form clinically routinely.
8. preparation method according to claim 7, is characterized in that, comprises the steps:
(1) take Radix Polygalae, Ganoderma, Rhizoma Polygonati, Fructus Lycii according to selected parts by weight, add purified water extraction 2 times, adding for the first time 10 times of weight water gagings extracts 1 hour, adding for the second time 8 times of weight water gagings extracts 1 hour, extracting liquid filtering, merging filtrate, while being evaporated to 70 DEG C, relative density is 1.10, obtains concentrated solution;
(2) above-mentioned concentrated solution is added appropriate amount of auxiliary materials spraying dry, obtain spraying dry powder, the dry powder of spraying is mixed homogeneously with Folium Ginkgo extract, and subpackage, to obtain final product.
9. according to the preparation method described in claim 7 or 8, it is characterized in that, described Folium Ginkgo extract prepares by the following method: get Folium Ginkgo and pulverize, add the ethanol of 6-12 times of weight amount 40%-80%, in 60 DEG C of-80 DEG C of reflux, extract, 1-3 time, each 1-4 hour, filter, merge extractive liquid, reclaim ethanol, by macroporous adsorbent resin on extracting solution, cross post with purified water and 10%-30% ethanol and remove impurity, then use 40%-80%% ethanol elution, collect eluent, concentrating under reduced pressure obtains dry extract, and dry extract is added to 60 DEG C of-80 DEG C of reflux, extract, of 95% ethanol, filter extracting solution, concentrating under reduced pressure obtains dry extract, pulverize, obtain.
10. add conventional adjuvant, the pharmaceutical preparation of making according to common process or health food, food by the pharmaceutical composition described in claim 1,2,5 or 6.
11. preparations according to claim 10, it is characterized in that, comprise granule, capsule, tablet, mixture, pill, syrup, electuary, medicated wine, tincture, soft extract, powder, injection, oral liquid, solid beverage, liquid beverage or bake and bank up with earth food.
Pharmaceutical composition described in 12. claim 1,2,5 or 6 has the purposes in medicine, health food or the food that improves memory effect in preparation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194091A (en) * | 2015-11-09 | 2015-12-30 | 中国热带农业科学院热带生物技术研究所 | Composition with effect of preventing senile dementia and preparation method thereof |
| CN112755074A (en) * | 2021-01-21 | 2021-05-07 | 上海普康药业有限公司 | Pharmaceutical composition containing oryzanol and preparation method and application thereof |
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2014
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194091A (en) * | 2015-11-09 | 2015-12-30 | 中国热带农业科学院热带生物技术研究所 | Composition with effect of preventing senile dementia and preparation method thereof |
| CN112755074A (en) * | 2021-01-21 | 2021-05-07 | 上海普康药业有限公司 | Pharmaceutical composition containing oryzanol and preparation method and application thereof |
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Application publication date: 20141022 |
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