CN104337920A - Traditional Chinese medicine composition for improving sleep quality - Google Patents
Traditional Chinese medicine composition for improving sleep quality Download PDFInfo
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- CN104337920A CN104337920A CN201410572308.3A CN201410572308A CN104337920A CN 104337920 A CN104337920 A CN 104337920A CN 201410572308 A CN201410572308 A CN 201410572308A CN 104337920 A CN104337920 A CN 104337920A
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Classifications
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Abstract
The invention relates to a traditional Chinese medicine composition for improving sleep quality. The active ingredients of the traditional Chinese medicine composition for improving sleep quality are prepared from main raw and auxiliary materials: spina date seeds, ginseng, lucid ganoderma, polygala tenuifolia and fructus schizandrae. According to conventional pharmaceutical methods, pharmaceutically acceptable auxiliary materials or auxiliary components are added to prepare a clinically acceptable conventional internal preparation (a health product) in pharmaceutics, including troches, tea bags, granules, capsules, pills and oral solutions. The traditional Chinese medicine composition provided by the invention is simple in prescription and has the characteristics of convenience in use and improvement of sleep quality. The traditional Chinese medicine composition provided by the invention is stable in preparation process, controllable in quality, good in repeatability and suitable for large-scale production.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of improving water flood quality.
Background technology
Insomnia is one of common disease clinically, not enough in primary symptom with the length of one's sleep, the degree of depth and allaying tiredness effect.Have difficulty falling asleep, dreaminess, easily wake up with a start, early awakening, insomnia-middle or the multiple situation such as to be all night insomnia.Frequent insomnia can bring great spirit and sensual misery to people, occurs many discomforts such as dizzy, tinnitus is forgetful, absent minded, has a strong impact on the quality of life of people.
Chinese medicine is thought, the ortho sleep of people be Yinyang from however regular conversion results." this moon of sleeping, also, Shen Anze's its master of god sleeps, and refreshing uneasiness is then insomnia "; And " vim and vigour person, the god of people ", above give in the heart then the mind must support, then liver body is soft to be hidden in liver, change and be essence, be built in kidney, the mind intersect then mind stabilize.The cause of disease of being insomnia is then intricate, and symptom deficiency and excess is visible, but clinical disturbing mainly with pathogen, or is common caused by ying-qi deficiency (for pondering over, overstrain, weakness due to chronic disease, seven emotions to become estranged etc. and cause, especially to cross happiness, cross anger, to cross and think or cross compassion be common).Sick position is at the heart, and often involve kidney,liver,spleen, gallbladder, pathological change is overabundance of YANG leading to deficiency of YIN, and negative and positive are lost and handed over.Chinese traditional treatment is with balanced human's negative and positive, and adjustment internal organs QI and blood is principle, is conceived to whole body conditioning, identification of etiology according to differenciation of symptoms and signs, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
Current people mainly based on hypnotic drug, also have assuasive medicine to be also used to clinical to the treatment of insomnia, and these medicines belong to nerve and control sleep, have instant effect, the features such as action time is short.But long-term taking easily produces drug dependence and toxic and side effects, as sleeping pill has dependency and additive, toxic and side effects is large, can suppress to breathe, lessen one's memory, unsuitable life-time service; Formula of biological agent is single, can not be fully absorbed again, is difficult to reach comprehensively, therapeutic effect thoroughly.Chinese medicine is started with from the integrally-regulated of body, less to human body toxic and side effects, without drug dependence.So the Chinese herbal medicine compositions inventing a kind of improving water flood is significant.
Summary of the invention
In order to overcome the above-mentioned deficiency of prior art, the invention provides a kind of component simple, active component is clear and definite, good stability, the Chinese medicine composition of quality controllable raising sleep quality.
For this reason, following technical scheme is adopted:
A pharmaceutical composition for improving water flood, its active component is made up of the crude drug of following weight proportioning: Semen Ziziphi Spinosae 150-220 parts, Radix Ginseng 30-80 parts, Ganoderma 40-80 parts, Radix Polygalae 40-80 parts, Fructus Schisandrae Chinensis 30-80 parts.
Further preferably, it is made up of the active component of following weight portion: Semen Ziziphi Spinosae 180 parts, Radix Ginseng 50 parts, Ganoderma 70 parts, Radix Polygalae 50 parts, Fructus Schisandrae Chinensis 50 parts.
Conveniently pharmaceutical methods, add pharmaceutically acceptable adjuvant or complementary composition, make said conventional oral preparations in said routine in acceptable, pharmaceutics clinically, comprise oral liquid, teabag, granule, capsule, pill or tablet.
The present invention has certain effect to improving model mice sleep quality, judge index mainly contains the pentobarbital sodium Sleep latency time, extends the pentobarbital sodium length of one's sleep and pentobarbital sodium sub-threshold dose sleep rate, especially more obvious on the impact of pentobarbital sodium sub-threshold dose, compared with negative control group, the increase of high dose group sleep number of animals has pole significant difference, and the increase of middle dosage group sleep number of animals has significant difference.
The present invention is except having effect of improving water flood quality, and ingredient also has good nutritive value and health care.The Semen Ziziphi Spinosae of the title of " China sleeps really " is wherein had to cure mainly vexed insomnia, spontaneous sweating; The ginsenoside that Radix Ginseng includes has good therapeutic effect to the central nervous system of mediator, treatment nervous system disease; Ganoderma is also effective sleeping medicine of allaying excitement, and plays good effect to maincenter; Radix Polygalae is used for insomnia and dreamful sleep, staring spells; Fructus Schisandrae Chinensis also has treatment spontaneous sweating effect.The preparation that the present invention makes does not contain chemical sleeping pill composition, determined curative effect, safe ready.
Semen Ziziphi Spinosae: sweet in the mouth, acid, property are put down.There is nourishing the liver, mind calming, calm the nerves, effect of arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility." not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen.”
Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian, heart channel.Have strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly that impairment caused by overstrain is deficient, food told in lack of appetite, asthenia, regurgitation, disease that stool lingering diarrhea, empty cough with asthma are short.
Ganoderma: property is sweet, flat.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.To human liver cancer cell, there is cytotoxicity, also can suppress the release of histamine, there is hepatoprotective effect and there is anti-allergic effects etc.Ganoderma extract energy exciting motion suppresses, mobility is reduced, coordination exercise is lacked of proper care, presents the sick effect in dose-dependent town, can curtail sleep to hexobarbital sleep effect, the time that central stimulants caffeine causes spasm and death can be extended, these results show, Ganoderma is inhibition effect to maincenter.
Radix Polygalae: warm in nature, bitter in the mouth, pungent, the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain." book on Chinese herbal medicine just " is recorded, Radix Polygalae, the wholwe-hearted kidney of merit, therefore can relieving palpitation spasmolytic, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.
Fructus Schisandrae Chinensis: nature and flavor temperature, acid, sweet.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming." herbal classic " is recorded, Fructus Schisandrae Chinensis " main QI invigorating, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence ".All good action is had to the insomnia cardiopalmus of the old deficiency of heart-blood of improvement, insufficiency of heart-QI, disarmony between the heart and kidney.Schisandrin B, SALLRSIPA SAL ADNF-9 schizronol schisanhenol all have antioxidation, and energy scavenging free radicals, suppression lipid peroxide are formed.In addition, Fructus Schisandrae Chinensis can reduce serum cholesterol, increases protein content in brain regulating liver-QI, all shows to have anti-aging effects.
Accompanying drawing explanation
Fig. 1 is that the present invention and documents (200710021857.1) are to the contrast extending the pentobarbital sodium hypnosis time;
Fig. 2 is that the present invention and the impact of documents (200710021857.1) on pentobarbital sodium sub-threshold dose syngignoscism contrast;
Fig. 3 is that the present invention and documents (200710021857.1) contrast the impact of barbital sodium Sleep latency.
In the block diagram of the every group in Fig. 1-Fig. 3, the column on the left side is result of the present invention, and the column on the right is the result of documents (200710021857.1).
Detailed description of the invention
Embodiment 1
A Chinese medicine composition for improving water flood quality, it is made up of the active component of following weight portion: Semen Ziziphi Spinosae 220 parts, Radix Ginseng 30 parts, Ganoderma 50 parts, Radix Polygalae 60 parts, Fructus Schisandrae Chinensis 40 parts.
Embodiment 2
A Chinese medicine composition for improving water flood quality, it is made up of the active component of following weight portion: Semen Ziziphi Spinosae 180 parts, Radix Ginseng 40 parts, Ganoderma 80 parts, Radix Polygalae 70 parts, Fructus Schisandrae Chinensis 30 parts.
Embodiment 3
A Chinese medicine composition for improving water flood quality, it is made up of the active component of following weight portion: Semen Ziziphi Spinosae 160 parts, Radix Ginseng 80 parts, Ganoderma 60 parts, Radix Polygalae 40 parts, Fructus Schisandrae Chinensis 80 parts.
Embodiment 4
A Chinese medicine composition for improving water flood quality, it is made up of the active component of following weight portion: Semen Ziziphi Spinosae 150 parts, Radix Ginseng 60 parts, Ganoderma 40 parts, Radix Polygalae 80 parts, Fructus Schisandrae Chinensis 70 parts.
Embodiment 5
A Chinese medicine composition for improving water flood quality, it is made up of the active component of following weight portion: Semen Ziziphi Spinosae 180 parts, Radix Ginseng 50 parts, Ganoderma 70 parts, Radix Polygalae 50 parts, Fructus Schisandrae Chinensis 50 parts.
The preferred preparation technology of the present invention is the preparation of oral liquid:
Prepared by oral liquid: take the Semen Ziziphi Spinosae of embodiment formula ratio respectively, Radix Ginseng, Ganoderma, Radix Polygalae, Fructus Schisandrae Chinensis put in multi-function extractor, and with 8 times amount 75% alcohol reflux 2 times, each 2 h, filtration, merge twice filtrate, medicinal residues are for subsequent use.Alcohol extract decompression recycling ethanol to without alcohol taste and to continue to be concentrated into relative density be 1.05 ~ 1.08(60 DEG C of mensuration), obtain alcohol extraction concentrated solution.Alcohol extraction medicinal residues add 8 times amount water boiling and extraction 2 times, each 1.5h.Filter, merge twice filtrate, filtering residue abandons it, obtains Aqueous extracts.Be 0.08Mpa by Aqueous extracts in vacuum, temperature is be evaporated to relative density 1.05 ~ 1.08(60 DEG C of mensuration under the condition of 70 ~ 80 DEG C), obtain water extracting liquid.Alcohol extraction concentrated solution and water extracting liquid are merged, cold preservation leaves standstill 48h.Filtered by concentrated solution after cold preservation, obtain filtrate, filtering residue discards.Filtrate is dropped in Agitation Tank, add appropriate sucralose, fully dissolve, then add purified water and be settled to enough, be uniformly mixed, obtain preparation liquid.Carry out centrifugal with supercentrifuge, centrifugal rotational speed is 15000r/min, discards precipitation, makes oral liquid, and 10ml/ bottle, to obtain final product.People's oral recommended dose is that 10ml/ props up, every day 3 times, each 1.
Prepared by granule: after component medical material is selected cleaning, uses alcohol extraction and water extraction technology to be extracted as and merges extractum shape, adds appropriate pharmaceutical excipient mixing, makes every gram of product and be equivalent to the granule of crude drug 5 grams and get final product.People's oral recommended dose is 3g/ bag, every day 3 times, each 1 bag.
Prepared by capsule: after component medical material is selected cleaning, uses alcohol extraction and water extraction technology to be extracted as and merges extractum shape, then uses spraying dry or hypobaric drying method to carry out drying, pulverizing; Add the mixing of appropriate pharmaceutical excipient, make the granule that every gram of product is equivalent to primary crude drug 12.5g, be filled in edible capsule and get final product, specification is 0.4g/ grain.People's oral recommended dose is every day 3 times, each 4.
Prepared by tablet: after component medical material is selected cleaning, uses alcohol extraction and water extraction technology to be extracted as and merges extractum shape, then uses spraying dry or hypobaric drying method to carry out drying, pulverizing; Add the mixing of appropriate pharmaceutical excipient, make the granule that every gram of product is equivalent to primary crude drug 12.5g, be pressed into the tablet of predetermined weight and get final product, specification is 0.4g/ grain.People's oral recommended dose is every day 3 times, each 4.
Prepared by teabag: after component medical material is selected cleaning, uses alcohol extraction and water extraction technology to be extracted as and merges extractum shape, then uses spraying dry or hypobaric drying method to carry out drying, pulverizing; Ovendry power is broken into coarse powder, then mixs homogeneously with extract powder, loads among bubble tea bag bag and get final product.
The production technology of above-mentioned preparation method and various application forms all belongs to existing known technology.
efficacy test research of the present invention
1 materials and methods
1.1 samples: the oral liquid prepared by the present invention, people's oral recommended dose is that 10ml/ props up, every day 3 times, each 1.With distilled water, oral liquid is made into test desired concn.
Beverage including angelica and dried orange peel for improving sleep quality (patent No. 200710021857.1): the beverage be prepared from by its specific implementation method.
1.2 laboratory animals: healthy ICR mice, male, institute of lab animals of body weight 18 ~ 22g(Sichuan Academy of Medical Sciences provides), the quality certification number is scxk(river) 2013-15.
1.3 dosage and grouping: laboratory animal is divided into 4 groups at random, often organize 12.200,100 if, 50ml/kgb.wt./d is respectively high, medium and low dosetest group (being equivalent to 5 times of clinical dosage, 10 times, 20 times respectively), separately set distilled water as negative control group.Each group equal every day per os gavage give tested material once, continuous 30 days, gavage capacity is 0.2ml/10g.bw.
1.4 instruments and reagent: pentobarbital sodium, barbital sodium (analytical pure) import subpackage.
2 experimental techniques
2.1 direct sleep laboratory last gavages terminate latter 15 minutes, matched group observes the sleep quality of mice after giving equal-volume distilled water, to be judged to more than 60 seconds with the righting reflex loss of animal and to enter sleep, awakening is reverted to righting reflex, righting reflex loss is the animal sleep time to recovering during this period of time, record sleep number of mice and the length of one's sleep.
2.2 extend pentobarbital sodium tests last gavage terminate latter 15 minutes the length of one's sleep, to each treated animal through lumbar injection pentobarbital sodium 45mg/kg.bw, injection volume 0.1ml/10g.bw, with the righting reflex loss of animal for index, record pentobarbital sodium length of one's sleep, observe given the test agent and can extend pentobarbital sodium length of one's sleep.
2.3 pentobarbital sodium sub-threshold dose hypnosis test last gavages terminate latter 15 minutes, to each treated animal through lumbar injection pentobarbital sodium 35mg/kg.bw, injection volume 0.1ml/10g.bw, observe the sleep quality of mice in 30 minutes, be sleep standard with righting reflex loss more than 60 seconds, the mice number that in record 30min, each group is fallen asleep.
2.4 barbital sodium Sleep latency experiment last gavages terminate latter 15 minutes, to each treated animal through lumbar injection barbital sodium 245mg/kg, injection volume 0.1ml/10g.bw, with animal righting reflex loss for index, record mice sleep incubation period, observe given the test agent and can shorten barbital sodium Sleep latency.
3 statistical analysiss
Carry out one factor analysis of variance with spss11.0 version software to experimental result, P < 0.05, P < 0.01 represents to have significant difference and pole significant difference respectively.
4 experimental results
After 4.1 direct sleep behaviors are observed and given mice various dose sample, all there is not phenomenon of sleeping in each dosage treated animal, shows that this sample acts on without direct sleep mice.
4.2 on extending the impact of pentobarbital sodium hypnosis time as can be seen from Table 1, tested object height, middle dosage group are compared with negative control group, mouse sleep time significantly improves (P < 0.05), shows that tested material has synergism to pentobarbital sodium, in table 1.
Table 1 tested material extends the pentobarbital sodium result of the test length of one's sleep
Note: * represents (p < 0.05); * represents (p < 0.01)
4.3 make each dosage group sleep mice number increase with dosage increase on the tested material that affects of pentobarbital sodium sub-threshold dose syngignoscism, compared with negative control group, the increase of high dose group sleep number of animals has pole significant difference (P < 0.01), the increase of middle dosage group sleep number of animals has significant difference (P < 0.05), show that tested material has synergism to pentobarbital sodium, in table 2.
Table 2 tested material is on the impact of pentobarbital sodium sub-threshold dose syngignoscism
Note: * represents (p < 0.05); * represents (p < 0.01)
4.4 on the impact of barbital sodium Sleep latency compared with negative control group, tested material high dose group Sleep latency shortens pole significant difference (P < 0.01), shows that tested material and barbital sodium have synergism, in table 3.
Table 3 tested material is on the preclinical impact of barbital sodium
Note: * represents (p < 0.05); * represents (p < 0.01)
4.5 is that the effect contrast of 200710021857.1 beverage including angelica and dried orange peel for improving sleep quality is studied with application number
Application number be 200710021857.1 patent prescription be Radix Angelicae Sinensis, Poria, Radix Ginseng, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Radix Polygalae, Semen Ziziphi Spinosae, Radix Scutellariae, Radix Paeoniae, Fructus Lycii, Semen Cuscutae, Ganoderma, Semen Platycladi, Radix Glycyrrhizae.Compared with the patent that the present invention and application number are 200710021857.1, prescription is simple, can reduce the body of patient, internal organs burden; Chemical composition is simple, strengthens pharmaceutical efficacy and curative effect; The composition that coexists is few, and result of extraction is good.In addition, prescription of the present invention has played the cheap and good-quality advantage of Chinese medicine, has adhered to Chinese medicine principle of medication, rigorous prescription, evident in efficacy.Concrete contrast test is as follows:
4.5.1 to the comparative study extending the pentobarbital sodium hypnosis time
As shown in Figure 1, wherein * * represents (P < 0.01); * (P < 0.05) is represented.
As can be seen from Figure 1, under high dose group, compared with the beverage including angelica and dried orange peel for improving sleep quality that oral liquid prepared by the present invention and application number are 200710021857.1, extremely significantly (P < 0.01) pentobarbital sodium length of one's sleep can be extended, in, significantly (P < 0.05) pentobarbital sodium length of one's sleep can be improved under low dose group, illustrate that improving water flood pharmaceutical composition action effect provided by the invention is better than the beverage including angelica and dried orange peel for improving sleep quality of the patent No. 200710021857.1.
4.5.2 on the impact of pentobarbital sodium sub-threshold dose syngignoscism
As shown in Figure 2, wherein * * represents (P < 0.01); * (P < 0.05) is represented.
As can be seen from Figure 2, under high and low dose group, compared with the beverage including angelica and dried orange peel for improving sleep quality that the oral liquid prepared of the present composition and application number are 200710021857.1, significantly (P < 0.05) quantity of sleep mice can be improved, illustrate that improving water flood pharmaceutical composition action effect provided by the invention is better than the beverage including angelica and dried orange peel for improving sleep quality of the patent No. 200710021857.1.
4.5.3 on the impact of barbital sodium Sleep latency
As shown in Figure 2, wherein * * represents (P < 0.01); * (P < 0.05) is represented.
As can be seen from Figure 3, under high and low dose group, compared with the beverage including angelica and dried orange peel for improving sleep quality that the oral liquid prepared of improving water flood pharmaceutical composition provided by the invention and application number are 200710021857.1, extremely significantly (P < 0.01) barbital sodium Sleep latency can be shortened, illustrate that improving water flood pharmaceutical composition action effect provided by the invention is better than the patent No. 200710021857.1 beverage including angelica and dried orange peel for improving sleep quality.
5 discuss
As can be seen from whole test, the Chinese medicine composition of improving water flood quality provided by the invention has the effect of collaborative Sleeping Time Prolong Ed, shortening barbital sodium Sleep latency, and the beverage including angelica and dried orange peel for improving sleep quality being 200710021857.1 with application number is compared, have significantly or extremely significant sleeping effect.
Claims (3)
1. a Chinese medicine composition for improving water flood quality, is characterized in that: its active component is made up of the crude drug of following weight proportioning: Semen Ziziphi Spinosae 150-220 parts, Radix Ginseng 30-80 parts, Ganoderma 40-80 parts, Radix Polygalae 40-80 parts, Fructus Schisandrae Chinensis 30-80 parts.
2. the Chinese medicine composition of a kind of improving water flood quality according to claim 1, is characterized in that: its active component is made up of the raw material of following weight proportioning: Semen Ziziphi Spinosae 180 parts, Radix Ginseng 50 parts, Ganoderma 70 parts, Radix Polygalae 50 parts, Fructus Schisandrae Chinensis 50 parts.
3. the Chinese medicine composition of a kind of improving water flood quality according to claim 1 and 2, it is characterized in that: with Semen Ziziphi Spinosae, Radix Ginseng, Ganoderma, Radix Polygalae, Fructus Schisandrae Chinensis for crude drug, add pharmaceutically acceptable adjuvant and conventionally make said conventional oral preparations in acceptable, pharmaceutics clinically, comprise oral liquid, teabag, granule, capsule, pill or tablet.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104940327A (en) * | 2015-06-04 | 2015-09-30 | 海南科技职业学院 | Traditional Chinese medicine composite for memory improvement |
| CN108066434A (en) * | 2018-01-19 | 2018-05-25 | 福建农林大学 | A kind of ganoderma lucidum Chinese medicine composition with soporific function and preparation method thereof |
| CN108126057A (en) * | 2018-01-29 | 2018-06-08 | 高志军 | A kind of drug for treating heart and lung diseases and preparation method thereof |
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| CN1390590A (en) * | 2002-06-20 | 2003-01-15 | 成都康弘制药有限公司 | Health-care food for improving sleep |
| WO2003084512A1 (en) * | 2001-10-03 | 2003-10-16 | Robert Gow | Oral delivery of a botanical |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003084512A1 (en) * | 2001-10-03 | 2003-10-16 | Robert Gow | Oral delivery of a botanical |
| CN1390590A (en) * | 2002-06-20 | 2003-01-15 | 成都康弘制药有限公司 | Health-care food for improving sleep |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940327A (en) * | 2015-06-04 | 2015-09-30 | 海南科技职业学院 | Traditional Chinese medicine composite for memory improvement |
| CN108066434A (en) * | 2018-01-19 | 2018-05-25 | 福建农林大学 | A kind of ganoderma lucidum Chinese medicine composition with soporific function and preparation method thereof |
| CN108066434B (en) * | 2018-01-19 | 2021-03-02 | 福建农林大学 | Ganoderma lucidum traditional Chinese medicine composition with sleep improving effect and preparation method thereof |
| CN108126057A (en) * | 2018-01-29 | 2018-06-08 | 高志军 | A kind of drug for treating heart and lung diseases and preparation method thereof |
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