CN1106678A - Medicine for treatment of gastroenteritis and gastroenteritic ulcer and preparing process thereof - Google Patents
Medicine for treatment of gastroenteritis and gastroenteritic ulcer and preparing process thereof Download PDFInfo
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- CN1106678A CN1106678A CN94109357A CN94109357A CN1106678A CN 1106678 A CN1106678 A CN 1106678A CN 94109357 A CN94109357 A CN 94109357A CN 94109357 A CN94109357 A CN 94109357A CN 1106678 A CN1106678 A CN 1106678A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Based on the pathological characteristics of pathogen and pharmacological characteristics of Chinese medicine components, the present invention selects at least one from Coptis chinensis, Phellodendron, senecio scandens, Chinese scholartree flower and Gonglaomu, at least one from evodia, notoginseng, Bletilla striata, radish seed and banksia rose, and at least one from Radix paeoniae alba, corydalis tuber, licorice root, Sarcandra glaber and radix bupleuri to dispense the said medicine. The present invention uses quarternary solvent of hydrochloric acid, alcohol, propanediol and water with changed concentration and temp gradients to extract the effective components in Chinese medicinal material. The said medicine is prepared in various forms.
Description
The present invention is the Chinese traditional treatment gastroenteritis, and the medicine of ulcer and technology are comprising pressing Chinese medicine and the preparation process thereof that presses down environment principle prescription in sterilization, protection mucosa, regeneration and restoration, the adjusting gastrointestinal.Existing treatment gastrointestinal inflammation, the method for Peptic Ulcers still have the traditional Chinese medical science to distinguish the disease method of treatment except the doctor trained in Western medicine method.Practice shows that the doctor trained in Western medicine side effect is big, the relapse rate height.The traditional Chinese medical science is pressed damp-heat in the spleen and stomach, and typings such as incoordination between the liver and stomach are dialectical, improve on the clinical symptoms slightly better.Total effective rate is about 90%.The gastroscopy pathology curative effect is about 60-70%.But because the backwardness of dialectical model and the aspect research of pathology pharmacology are incomplete.Chinese and western medical does not all have the active drug of thorough healing.
For example: have the people to combine with clinical disease, cure the disease and control the bonded principle of disease according to the chronic gastroenteritis pathological change.Antiinflammatory is proposed, the rule of treatment of blood stasis dispelling, function of spleen and stomach regulating, but on medicament selection, do not fully take into account the pharmacology characteristics of pathogen pathology and medicine, effect is unsatisfactory.
In addition, traditional Chinese medical science decoct has two big drawbacks.The one, the difficult clothes of bitter in the mouth, the 2nd, decocting can not propose the effective ingredient of some drugs fully.The medication inconvenience, expected effect can not be brought into play.Therefore, should take into full account gastrointestinal inflammation, the clinical pharmacology characteristics of the pathological characteristic of Peptic Ulcers pathogen and Chinese crude drug are selected medicament composing prescription, and utilize suitable technology to propose wherein effective ingredient, are processed into preparation easily, the performance expected effect.
The objective of the invention is by gastroenteritis the etiology and pathology characteristics of ulcer.Selection has sterilization, the protection mucosa, and regeneration and restoration, the Chinese medicine of spasmolytic, pain relieving, adjusting gastrointestinal function is formed prescription.According to the characteristics of Chinese medicine ingredients and pharmacology, adopt suitable technology effective component extracting to form compound preparation then, can be applicable to that Chinese medical discrimination is various.
The present invention is achieved in that by pressing down sterilization and selects at least a in Rhizoma Coptidis, Cortex Phellodendri, Herba Senecionis Scandentis, Flos Sophorae, the Caulis Mahoniae for use for main effect; By the protection mucosa, tissue repair is selected at least a in Fructus Evodiae, Radix Notoginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Aucklandiae, the Semen Raphani for use for main effect; By environment in analgesia, spasmolytic, gastrointestinal protection, the adjusting gastrointestinal is that main separation is write out a prescription with at least a composition in Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Corydalis, Herba Sarcandrae, the Radix Bupleuri.
Preparation technology is: in the said medicine, Radix Notoginseng, Semen Raphani, the Pseudobulbus Bletillae (Rhizoma Bletillae), the former medicated powder of Fructus Evodiae is broken is the 60-120 order, partly or entirely is used for preparation with former medicated powder shape.Other residue Rhizoma Coptidis, Cortex Phellodendri, Radix Glycyrrhizae etc. are crushed to more than 20 orders, utilize hydrochloric acid-ethanol-third=alcohol-water quaternary solvent, change the extraction that cooperates the thermograde variation to finish effective ingredient with the each component Concentraton gradient, the solvent that filters rear filtrate utilizes azeotropic distillation to reclaim.Extract and undrawn former medicated powder mixing granulation after concentrating add in case of necessity with Pulvis Talci or kaolin granulation, according to circumstances further make diffusing, ball, sheet, capsule and are used for clinical.Also prescription medicine all can be extracted and make Emulsion, lotion, unguentum, oral liquid are used for clinical, outside decapacitation treatment gastrointestinal inflammation, the ulcer, still can be used for treating oral inflammation ulcer, bacillary, trichomonal vaginitis, scytitis, diseases such as anal fissure.
The invention has the advantages that: one, select for use Rhizoma Coptidis, Cortex Phellodendri, Herba Senecionis Scandentis, Flos Sophorae, Caulis Mahoniae that helicobacter pylori, campylobacter jejuni are had strong inhibitory or killing effect, can remove the malignant bacteria that causes gastroenteritis, Peptic Ulcers.Utilize protection such as Fructus Evodiae, Radix Notoginseng gastric mucosa, the interior environment of spasmolytic, pain relieving, adjusting gastrointestinal that impels tissue regeneration and utilize Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae etc. is to improve symptom.Each medicine is mutually promoted, and is collaborative mutually, heightens the effect of a treatment, lowers side effect.Can improve symptom, can press down removing extremely again and cause that the antibacterial of pathological changes is to effect a permanent cure.
Two, adopt quaternary solvent strength gradient to cooperate thermograde can guarantee the abundant extraction of effective ingredient among the preparation technology.And the solvent azeotropic reclaims convenient.
Three, oral formulations is convenient uses, and can be applicable to that the traditional Chinese medical science distinguishes that disease is various.
Four, used medicine is nontoxic, low drugs, adds that compatibility prevents side effect.The side effect of patent medicine is low, is better than the western medical treatment medicine, helps adhering to taking medicine.
Five, this medicine still can be used for the treatment of cholecystitis, anal fissure, esophagitis, infectious diarrhea, dysentery.
Six,, make emulsifiable paste, lotion, unguentum, then can be used for treating oral ulcer, anal fissure, anal fistula, bacterial vaginitis, trichomonal vaginitis, scytitis if this medicine all components is all extracted processing.
Below lifting row is illustrated: write out a prescription and make capsule for the medicine warp of Rhizoma Coptidis, Fructus Evodiae, the Radix Aucklandiae, the Radix Paeoniae Alba, Rhizoma Corydalis by preceding described method, be used for the treatment of chronic gastroenteritis, remove pathogenic bacterium in 60 days.Inflammation, redness, hemorrhage, rotten to the corn pathological changes disappear, tissue repair is normal, and gastrointestinal function improves, and diet is good.Cure rate reaches 93%.Clinically do not see the untoward reaction of taking medicine.And McAb against gastric carcinoma is turned out cloudy.
Claims (5)
1, a kind of treatment gastroenteritis, the medicine of ulcer and technology.It is characterized in that the pharmacology of protection mucosa, tissue repair, spasmolytic, pain relieving, adjusting gastrointestinal function is selected three groups of medical material prescriptions for use by pressing down sterilization.Take the solvent gradient to cooperate thermograde to extract among the preparation technology, reclaim and make diffusing, sheet, ball, capsule behind the solvent.
2, described medicine of claim 1 and technology.It is characterized in that having selected for use following three groups of medicines, in every group choosing use at least a kind of, through precomminution with composite after extracting.These three groups of medicines are: (1) Rhizoma Coptidis, Cortex Phellodendri, Herba Senecionis Scandentis, Flos Sophorae, Caulis Mahoniae; (2) Fructus Evodiae, Semen Raphani, Radix Notoginseng, the Radix Aucklandiae, the Pseudobulbus Bletillae (Rhizoma Bletillae); (3) Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis, Herba Sarcandrae, Radix Bupleuri.
3, described medicine of claim 1 and technology is characterized by when preparation Radix Notoginseng, Semen Raphani, the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Evodiae and pulverize to 60-120 fine powder rear section or all be used for compositely, and residual drug is utilized hydrochloric acid-ethanol-third=alcohol-water quaternary solvent extraction.Each concentration of component echelon of solvent changes the variation of cooperation thermograde during extraction.
4, described medicine of claim 1 and technology, its characteristics are that preparation can be ball, sheet, diffusing, capsule.Can also be used for the treatment of cholecystitis, anal fissure, esophagitis, infectious diarrhea, dysentery.
5, described medicine of claim 2 and technology are if all medicine is made emulsifiable paste, lotion, unguentum, oral liquid all through solvent extraction.Except that being used for the treatment of gastroenteritis, ulcer, also be used for the treatment of anal fissure, bacterial vaginitis, trichomonal vaginitis, oral ulcer, scytitis.
Priority Applications (1)
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CN94109357A CN1106678A (en) | 1994-08-23 | 1994-08-23 | Medicine for treatment of gastroenteritis and gastroenteritic ulcer and preparing process thereof |
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CN94109357A CN1106678A (en) | 1994-08-23 | 1994-08-23 | Medicine for treatment of gastroenteritis and gastroenteritic ulcer and preparing process thereof |
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CN1106678A true CN1106678A (en) | 1995-08-16 |
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Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1058890C (en) * | 1997-08-13 | 2000-11-29 | 宋周能 | Weichangning powder for curing gastroenteritic diseases |
CN1063337C (en) * | 1996-07-04 | 2001-03-21 | 陈继忠 | Chinese medicine preparation for stomatocace |
CN1313130C (en) * | 2004-12-08 | 2007-05-02 | 北京华尔孚制药公司 | Medicine composition for treating stomachache, its preparation method and uses |
CN101214349B (en) * | 2007-12-29 | 2010-12-15 | 高彦越 | Medicine for treating peptic ulcer |
CN102166284A (en) * | 2011-03-29 | 2011-08-31 | 山西黄河中药有限公司 | Medicine for treating reflux esophagitis and preparation method thereof |
CN102293972A (en) * | 2011-08-25 | 2011-12-28 | 宁夏医科大学 | Extract for adjusting female vaginal microecology |
CN102327328A (en) * | 2011-09-28 | 2012-01-25 | 广东紫金正天药业有限公司 | Bistort rhizome-containing composition and application thereof |
CN102357215A (en) * | 2011-11-16 | 2012-02-22 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
CN102406903A (en) * | 2011-11-30 | 2012-04-11 | 宋爱民 | Traditional Chinese preparation for treating gastroxynsis |
CN102697926A (en) * | 2012-06-12 | 2012-10-03 | 查迅 | Chinese medicinal ointment for treating ulcerative colitis and preparation method thereof |
CN103239538A (en) * | 2013-01-15 | 2013-08-14 | 湖南新汇制药股份有限公司 | Helicobacter pylori-resisting pharmaceutical composition for stomach illness |
CN103505629A (en) * | 2013-08-31 | 2014-01-15 | 宋景戈 | Traditional Chinese medicine composition for treating acute gastroenteritis |
CN104248666A (en) * | 2009-03-13 | 2014-12-31 | Cj医药健康株式会社 | Compositions for preventing or improving gastrointestinal diseases |
CN107582856A (en) * | 2017-10-13 | 2018-01-16 | 佛山科学技术学院 | A kind of medicine ' Suyusan ' for treating agent for treating canker sore |
CN116270489A (en) * | 2023-03-22 | 2023-06-23 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
-
1994
- 1994-08-23 CN CN94109357A patent/CN1106678A/en active Pending
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1063337C (en) * | 1996-07-04 | 2001-03-21 | 陈继忠 | Chinese medicine preparation for stomatocace |
CN1058890C (en) * | 1997-08-13 | 2000-11-29 | 宋周能 | Weichangning powder for curing gastroenteritic diseases |
CN1313130C (en) * | 2004-12-08 | 2007-05-02 | 北京华尔孚制药公司 | Medicine composition for treating stomachache, its preparation method and uses |
CN101214349B (en) * | 2007-12-29 | 2010-12-15 | 高彦越 | Medicine for treating peptic ulcer |
CN104248666A (en) * | 2009-03-13 | 2014-12-31 | Cj医药健康株式会社 | Compositions for preventing or improving gastrointestinal diseases |
CN102166284B (en) * | 2011-03-29 | 2012-06-27 | 山西黄河中药有限公司 | Medicine for treating reflux esophagitis and preparation method thereof |
CN102166284A (en) * | 2011-03-29 | 2011-08-31 | 山西黄河中药有限公司 | Medicine for treating reflux esophagitis and preparation method thereof |
CN102293972A (en) * | 2011-08-25 | 2011-12-28 | 宁夏医科大学 | Extract for adjusting female vaginal microecology |
CN102293972B (en) * | 2011-08-25 | 2013-06-19 | 宁夏医科大学 | Extract for adjusting female vaginal microecology |
CN102327328A (en) * | 2011-09-28 | 2012-01-25 | 广东紫金正天药业有限公司 | Bistort rhizome-containing composition and application thereof |
CN102357215A (en) * | 2011-11-16 | 2012-02-22 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
CN102357215B (en) * | 2011-11-16 | 2013-01-02 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
CN102406903A (en) * | 2011-11-30 | 2012-04-11 | 宋爱民 | Traditional Chinese preparation for treating gastroxynsis |
CN102406903B (en) * | 2011-11-30 | 2014-01-15 | 宋爱民 | Traditional Chinese preparation for treating gastroxynsis |
CN102697926A (en) * | 2012-06-12 | 2012-10-03 | 查迅 | Chinese medicinal ointment for treating ulcerative colitis and preparation method thereof |
CN102697926B (en) * | 2012-06-12 | 2013-11-27 | 查迅 | Chinese medicinal ointment for treating ulcerative colitis and preparation method thereof |
CN103239538A (en) * | 2013-01-15 | 2013-08-14 | 湖南新汇制药股份有限公司 | Helicobacter pylori-resisting pharmaceutical composition for stomach illness |
CN103239538B (en) * | 2013-01-15 | 2015-07-29 | 湖南新汇制药股份有限公司 | A kind of gastropathy drug composition of anti-helicobacter pylori |
CN103505629A (en) * | 2013-08-31 | 2014-01-15 | 宋景戈 | Traditional Chinese medicine composition for treating acute gastroenteritis |
CN103505629B (en) * | 2013-08-31 | 2015-06-17 | 宋景戈 | Traditional Chinese medicine composition for treating acute gastroenteritis |
CN107582856A (en) * | 2017-10-13 | 2018-01-16 | 佛山科学技术学院 | A kind of medicine ' Suyusan ' for treating agent for treating canker sore |
CN116270489A (en) * | 2023-03-22 | 2023-06-23 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
CN116270489B (en) * | 2023-03-22 | 2023-09-08 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
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