CN1056078C - Traditional Chinese Medicine- - Google Patents

Abstract

The present invention relates to a Weichangshu which is a drug for medicinal treatment to cure patients with liver-stomach disharmonious diseases, such as gastric ulcer, duodenal ulcer and chronic gastritis, and a preparation method of the drug. Nine plant drugs of coptis, rhubarb, etc. are taken to form the formula, and advanced preparation processes are adopted which comprise: volatilization adopts the technique of inclusion compound; heating technology is replaced with decompress concentrating and drying at a low temperature; quality control process adopts monitoring berberine hydrochloride in the coptis, and more than half of the drugs in the formula. The medicine of the present invention has good therapeutic effect, less side effect, convenient sources of raw materials, no poison by clinic verification and no discovered toxic or side effect.

Description

A kind of stomach function regulating analgesic

The present invention relates to a kind of medical Chinese patent medicine, particularly a kind of Chinese patent medicine that derives from vegetable drug.

Stomach, duodenal ulcer and chronic gastritis are common frdquently encountered disease, and sickness rate has the trend that progressively raises.Wherein see with liver-stomach disharmony type especially, and often double gas enclosure stagnates, blood stasis or hot and suffocating more.In the prior art, the new Chinese medicine of establishing, having better curative effect at above disease liver-stomach disharmony type patient is more rare, and curative effect is relatively poor.

Purpose of the present invention is intended to avoid the deficiencies in the prior art and a kind of pharmaceutical drugs that stomach, duodenal ulcer and chronic gastritis belong to the liver-stomach disharmony type patient that solves---stomach function regulating analgesic is provided.

The object of the present invention is achieved like this:

A kind of stomach function regulating analgesic is characterized in that being made by Rhizoma Coptidis, Radix Et Rhizoma Rhei, Fructus Amomi, Fructus Evodiae, Herba Taraxaci, Flos Caryophylli, Radix Bupleuri, the Radix Aucklandiae and Rhizoma Corydalis vegetable drug, and prescription by weight percentage is as 1. Rhizoma Coptidis 11-16 Fructus Evodiae 5-8 Radix Bupleuri 11-16

Radix Et Rhizoma Rhei 11-16 Herba Taraxaci 11-16 Radix Aucklandiae 10-15

Fructus Amomi 6-10 Flos Caryophylli 2-6 Rhizoma Corydalis 11-16

2. Rhizoma Coptidis, Fructus Evodiae, the Radix Aucklandiae, Rhizoma Corydalis four Chinese medicine material in will filling a prescription, the 30-60 minute post-heating of acetum dipping that adds 0.2-0.7% extracts 2-3 time, and it is the thick paste 1 of 1.30-1.35 that medical filtration, concentrating under reduced pressure must be measured relative density at 80 ℃;

3. Flos Caryophylli, Fructus Amomi two flavors in will filling a prescription, heating decocts 2-3 time and collects volatile oil, and beta-cyclodextrin inclusion compound is used in the oil dehydration, and is standby;

4. Radix Bupleuri, Herba Taraxaci, Radix Et Rhizoma Rhei three flavors add deionized water dipping 30-60 minute in will filling a prescription, and heating decocts 2-3 time, filter to merge Flos Caryophylli group filtrate, and it is the thick paste 2 of 1.28-1.36 that concentrating under reduced pressure must be measured relative density at 80 ℃;

Thick paste 1, thick paste 2 merging are added appropriate amount of starch and stir at 40 ℃-60 ℃, behind the vacuum drying, pulverize, sieve, powder gets dry extract;

Add the appropriate amount of starch mixing again with Benexate Hydrochloride and dried cream powder, the 0-2 capsule or be pressed into tablet of packing into.

The invention will be further described with embodiment with reference to the accompanying drawings below;

Accompanying drawing 1 is a process chart of the present invention.

Embodiment: choose four Chinese medicine materials such as Rhizoma Coptidis 250 grams, Fructus Evodiae 120 grams, the Radix Aucklandiae 230 grams, Rhizoma Corydalis 250 grams, add 0.5% acetum dipping after 45 minutes, the heating extraction secondary, 2 hours for the first time, 1.5 hours for the second time, medical filtration, concentrating under reduced pressure get thick paste 1 (relative density 1.30-1.35,80 ℃).Choose Flos Caryophylli 75 grams, Fructus Amomi 150 grams two flavors, heating decocts secondary, 2 hours for the first time, also collect volatile oil 1.5 hours second time, and leaching secondary medicinal liquid is incorporated Radix Bupleuri group extracting solution into and concentrated, and continue to collect volatile oil 2.5 hours, β-CDBao He is used in the oil dehydration, and is standby; Choose Radix Bupleuri 250 grams, Herba Taraxaci 250 grams, Radix Et Rhizoma Rhei 250 grams three flavors, add dried up dipping 45 minutes, heating decocts secondary, 2 hours for the first time, 1.5 hours for the second time, filter merging Flos Caryophylli group filtrate, concentrating under reduced pressure gets thick paste 2 (relative density 1.30-1.35,80 ℃).Two groups of thick pastes are added appropriate amount of starch stir, behind the vacuum drying (50 ℃), pulverize, cross 40 mesh sieves, powder gets dry extract.With dried cream powder, beta-CD inclusion and appropriate amount of starch mixing in No. 0 capsule of packing into or be pressed into tablet, make 1000 (sheets), promptly get stomach function regulating acesodyne capsule or tablet.

The present invention's advantage compared with prior art is; Good effect, few side effects, raw material sources Convenient, preparation technology advanced person, quality control are tight.

1, proves through Traditional Chinese Medicine University Of Guangzhou's pharmacodynamics test; To acute gastric mucosal lesion, anxious, The chronic gastric ulcer disease has obvious preventive and therapeutic effect, can gastric acid secretion inhibiting. Through clinical verification and Stomach and alleviating pain treatment group total effective rate reaches 92.93%, and the control group total effective rate is 81.67 %. High more than 10% with stomach and alleviating pain clinical efficacy contrast group, two groups there were significant differences. Level is in a leading position in the similar drug.

2, Weichangshu toxicological test result shows that medicine is substantially nontoxic, in the clinical application process not Find toxic and side effect.

3, raw material sources are convenient, and the prescription Chinese medicine all has the drug standards, all record " in State's pharmacopeia " in nineteen ninety-five one one of the version, general medicinal material company all can purchase.

4, preparation technology advanced person; Volatile oil of the present invention adopts the inclusion compound technology, changes tradition Packing or compressing tablet before spray in the particle, be conducive in the storage process to reduce the loss of volatile oil; Process using reduced pressure concentration and low temperature drying that production process need to heat have reduced temperature to having The destruction of effect composition. Preparation process is stable, and can reach more than 2 years stationary phase.

5, quality control is tight; The present invention the prescription in monarch drug in a prescription---the coptis is major control Medicine is measured content of berberine hydrochloride wherein. And the total amount of having determined nearly to write out a prescription is over half Medicinal material differentiate.

The present invention's medicine has clearing liver and stomach, falls the contrary effect that presses down acid, regulating qi-flowing for relieving pain. Be suitable for Epigastric distending pain due to the liver-stomach disharmony, or pain connects two sides of body, warm tongue acid, noisy, the dry mouth Wait bitterly for disease. Also can be used for gastric and duodenal ulcer, chronic gastritis and other illness see have above-mentioned Symptom belongs to the treatment of liver-stomach disharmony.

Claims (1)

1, a kind of stomach function regulating analgesic, it is characterized in that being made by Rhizoma Coptidis, Radix Et Rhizoma Rhei, Fructus Amomi, Fructus Evodiae, Herba Taraxaci, Flos Caryophylli, Radix Bupleuri, the Radix Aucklandiae and Rhizoma Corydalis vegetable drug, prescription by weight percentage is as 1. Rhizoma Coptidis 11-16 Fructus Evodiae 5-8 Radix Bupleuri 11-16

Radix Et Rhizoma Rhei 11-16 Herba Taraxaci 11-16 Radix Aucklandiae 10-15

Fructus Amomi 6-10 Flos Caryophylli 2-6 Rhizoma Corydalis 11-16

2. with Rhizoma Coptidis, Fructus Evodiae, the Radix Aucklandiae, Rhizoma Corydalis four Chinese medicine material in the prescription, the 30-60 minute post-heating of acetum dipping that adds 0.2-0.7% extracts 2-3 time, and it is the thick paste 1 of 1.30-1.35 that medical filtration, concentrating under reduced pressure must be measured relative density at 80 ℃;

3. with Flos Caryophylli, Fructus Amomi two flavors in the prescription, heating decocts 2-3 time and collects volatile oil, and beta-cyclodextrin inclusion compound is used in the oil dehydration, and is standby;

4. with Radix Bupleuri, Herba Taraxaci, Radix Et Rhizoma Rhei three flavors in the prescription, add deionized water dipping 30-60 minute, heating decocts 2-3 time, filters to merge Flos Caryophylli group filtrate, and it is the thick paste 2 of 1.28-1.36 that concentrating under reduced pressure must be measured relative density at 80 ℃;

Thick paste 1, thick paste 2 merging are added appropriate amount of starch and stir at 40 ℃-60 ℃, behind the vacuum drying, pulverize, sieve, powder gets dry extract;

Add the appropriate amount of starch mixing again with Benexate Hydrochloride and dried cream powder, the 0-2 capsule or be pressed into tablet of packing into.

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