CN101982194B - Coptis root compound preparation for treating dampness-heat spleen encumbering type diabetes - Google Patents
Coptis root compound preparation for treating dampness-heat spleen encumbering type diabetes Download PDFInfo
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- CN101982194B CN101982194B CN2010105476976A CN201010547697A CN101982194B CN 101982194 B CN101982194 B CN 101982194B CN 2010105476976 A CN2010105476976 A CN 2010105476976A CN 201010547697 A CN201010547697 A CN 201010547697A CN 101982194 B CN101982194 B CN 101982194B
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Abstract
The invention relates to a traditional Chinese medicine compound preparation for treating dampness-heat spleen encumbering type diabetes, which comprises the following components of 1-90% of Mongolian snakegourd root, 0.1-60% of grassleaf sweelflag rhizome, 0.1-40% of coptis root, 0.1-40% of round cardamom, 0-40% of coix seed, 0-40% of wrinkled gianthyssop herb, 0-40% of atractylodes rhizome, 0-40% of officinal magnolia bark, 0-40% of alisma rhizome and the like. The preparation method of the compound preparation comprises the following steps: crushing the raw materials into fine powder and pelleting; or carrying out reflux extraction with medicinal alcohol (or water) for 10 to 120 minutes, filtering to obtain extracting solution, concentrating until being dry, encapsuling or tabletting or pelleting; or concentrating the extracting solution into a half of the volume of the raw medicinal materials, sterilizing and bottling. The product is taken according to 1-50g or 5-20ml of the concentrated solution per person per day and has obvious blood sugar reduction effect.
Description
Technical field
The invention belongs to Chinese herbal compound preparation, be specifically related to a kind of compound Chinese medicinal preparation of treating damp and hot tired spleen type diabetes.
Background technology
Diabetes have become the significant problem that threatens human health.The number of China's diabetics ranks first in the world, and it is surprising to gather way: about 8,000 ten thousand people of China's diabetes (containing hyperglycemia) patient sum according to the preliminary statistics are mainly type 2 diabetes mellitus; China's type 2 diabetes mellitus sickness rate in 1979 is merely 1.00%, 1994 year prevalence and has risen to 2.5%, has broken through 5% at present.The advantage of performance Chinese medicine is made an effort for the prevention and the treatment of diabetes, is the huge contribution to the mankind.
Radix Trichosanthis is the cucurbitaceous plant Fructus Trichosanthis
Trichosanthes kirilowiiMaxim. or trichosanthes rosthornii Harms
Trichosanthes rosthorniiThe dry root of Harms; Sweet, the little hardship of property, be slightly cold; Attach to the lung and stomach meridians, have effects such as clearing heat, purging intense-heat, promoting the production of body fluid to quench thirst, detumescence and apocenosis, be used for calentura excessive thirst, lung-heat type cough, interior-heat quench one's thirst (diabetes), sore swollen toxin (" 2010 editions one one 52 pages of Chinese pharmacopoeia).The main component of Radix Trichosanthis be protein, starch, lectins, polysaccharide, saponin etc. (Li Zhenhong, Lu Yang, Liu Jingxing. Radix Trichosanthis chemical constituent and pharmacologically active [J]. external medical plant amedica fascicle, 2003,18 (1): 1-4); Its lectins (Radix Trichosanthis agglutinin) have that the lipotropism fat decomposes and promote ILA such as lipogenesis (Chou Weixin. Radix Trichosanthis pharmaceutical research progress [J]. Chinese Chinese medicine information magazine, 1996,3 (6): 11-13), have hypoglycemic activity; The Japan scholar is also isolating to a plurality of hypoglycemic activity composition (Hikino H from Radix Trichosanthis; Et al. Isolation and hypoglycemic activity of trichosans A; B, C, D and E:glycans of Trichosanthes kirilowii roots. Planta Medica; 1989,55 (4): 349).In the ancient prescription of Chinese medicine; Radix Trichosanthis in a large number as hypoglycemic medicine (Zhou Jun, Feng Yan. the period of Ming and Qing medical record 59 routine medication statistical analysiss [J] of quenching one's thirst. traditional Chinese medical science forum, 2005; 20 (6): 18); And frequency of utilization very high (Zheng Hong. the prescription compatibility The law [J] of Chinese traditional treatment diabetes. Shandong Traditional Chinese Medicine University's journal, 2008,32 (4): 286); Variola is divided the medicine as treatment diabetes (diabetes), for middle slake diabetes due to kidney-deficiency all have better curative effect (Sun Fenglei, high China. Compendium of Material Medica treatment diabetes medicine simple analysis [J]. Liaoning Journal of Traditional Chinese Medicine, 2003,30 (2): 83).
Rhizoma Coptidis is the ranunculaceae plant Rhizoma Coptidis
Coptis chinensisFranch
., Coptis deltoidea C.Y.Cheng et Hsiao
Coptis deltoidea C. Y.Cheng et Hsiao or Coptis Teeta Wall
Coptis teetaWall
.Dry rhizome; The property bitter, cold; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel have the effect of heat clearing and damp drying, eliminating fire and detoxication, all diseases such as be used to quench one's thirst (diabetes), damp and hot feeling of fullness, vomiting acid regurgitation, dysentery (" 2010 editions one one 285 pages of Chinese pharmacopoeia).The main active of Rhizoma Coptidis is berberine Rhizoma Coptidis alkaloids such as (BBR).BBR has blood sugar lowering, correct lipid metabolic disorder, reduce body weight, improve function such as insulin resistant (appoint firm, Yang Jing.Berberine is treated the progress of 2 type diabetes mechanism of action.Combination of Chinese and Western medicine cardiovascular and cerebrovascular disease magazine, 2008,6 (2): 208～210); BBR can increase the HepG2 cell to the consumption of glucose, suppress cell (3T3-L1) before the fat differentiation, increase HepG2 cell surface low density lipoprotein receptor (LDLR) content, suppress the lipogenesis enzyme activity, increase adipose cell secretion adiponectin and suppress the secretion etc. of leptin; Thereby show good hypoglycemic activity (appoint firm, Yang Jing.Berberine is treated the progress of 2 type diabetes mechanism of action.Combination of Chinese and Western medicine cardiovascular and cerebrovascular disease magazine, 2008,6 (2): 208～210); BBR can suppress the adipose cell differentiation, when improving insulin resistant, can lose weight and blood fat reducing, and its blood sugar reducing function does not rely on the release of insulin and summation action is arranged, and in correcting glycolipid metabolism, has unique mechanism and curative effect.Therefore, Rhizoma Coptidis and active component thereof (BBR) are the natural drugs of more satisfactory treatment diabetes.
Rhizoma Acori Graminei is an acorus gramineus araceae plant
Acorus tatarinowiiThe dry rhizome of Schott; The property hot, bitter, warm; GUIXIN, stomach warp have effects such as the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae, removing dampness appetizing, are used for that coma epilepsy, forgetful insomnia, Hiccough and deaf, gastral cavity painful abdominal mass are not hungry, mouthful dysentery of keeping silent (" 2010 editions one one 85 pages of Chinese pharmacopoeia).The main active of Rhizoma Acori Graminei is a volatile oil, comprises that (Li Ji comes materials such as beta-Asarone, α-asaricin, Chen Feilong; He Feng; Deng. the comparative study [J] of the GC of Rhizoma Acori Graminei volatile oil composition-MS analysis and Different Extraction Method. Chinese crude drug, 2001,24 (7): 494 – 495).Rhizoma Acori Graminei and active component thereof are used to data cardiovascular disease (Wu Qiduan.The pharmacodynamic study and the mechanism of Rhizoma Acori Graminei volatile oil and beta-Asarone control acute myocardial infarction are inquired into.Traditional Chinese Medicine University Of Guangzhou's master thesis.2006）。
Fructus Amomi Rotundus is the zingiberaceous plant Fructus Amomi Rotundus
Amomum kravanhPierre ex Gagnep. or melon Fructus Amomi Rotundus
Amomum compactumThe dry mature fruit of Soland ex Maton..The property hot, temperature is returned lung, spleen, stomach warp, has the removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, the effect of appetite-stimulating indigestion-relieving.The effective ingredient of Fructus Amomi Rotundus has volatility or sublimability (Liu's generaI investigation, Zhao Haifeng, Song Yijun, Ji Defu, Hou Minna.Fructus Amomi Rotundus volatile oil Study on extraction.The ShanXi Chinese Medicine Academy journal, 2007,30 (5): 75～77).
The traditional Chinese medical science is divided into type in 5 (" study of tcm new drug clinical guidance principle ", 2003) with " diabetes " (diabetes): and intense heat due to deficiency of YIN card (dry mouth and throat, vexed fear heat), damp and hot tired spleen card (breast gastral cavity abdominal distention, or the food back is full; Heaviness sensation over the head and body), (acid of waist knee joint is cold for spiritlessness and weakness, dry mouth and throat for syndrome of deficiency of both qi and yin (dry mouth and throat, fatigue and weakness), deficiency syndrome of both YIN and YANG and blood stasis causing water retention card; Or brothers' fear of cold, nocturia), blood stasis venation card (chest pain, hypochondriac pain; Lumbago, backache, the position is fixed; Or for twinge, numb limbs and tense tendons, pain night is very) etc.The compound recipe that Chinese medicine is used to treat diabetes is a lot, is used for treatment " intense heat due to deficiency of YIN ", " deficiency of both QI and YIN ", " deficiency of both YIN and YANG ", " blood stasis venation " and waits the Chinese medicine preparation of 4 type diabetess more, and the Chinese medicine preparation of treating " damp and hot tired spleen " type diabetes is few.
This method is the basis with the ancient prescription " Rhizoma Acori Graminei looses " (" Shengji Zonglu " volume 59 " Rhizoma Acori Graminei looses ": Rhizoma Acori Graminei one or two, two liang of RADIX TRICHOSANTHISs, Rhizoma Coptidis half two) of treatment " diabetes "; Add Fructus Amomi Rotundus with removing dampness circulation of qi promoting effect; To strengthen the effect (Radix Trichosanthis, Rhizoma Coptidis, Rhizoma Acori Graminei, the Radix Aucklandiae) of the compound recipe of treating " damp and hot tired spleen " type diabetes, do not appear in the newspapers as yet.
Summary of the invention
The objective of the invention is to provides a kind of Rhizoma Coptidis compound preparation of treating damp and hot tired spleen type diabetes to the prior art defective.
The Chinese medicine compound of this treatment diabetes comprises the raw material of Chinese medicine of following percentage by weight: Radix Trichosanthis 1～90%, Rhizoma Acori Graminei 0.1～60%, Rhizoma Coptidis 0.1～40%, Fructus Amomi Rotundus 0.1～40%, Semen Coicis 0～40%, Herba Pogostemonis 0～40%, Rhizoma Atractylodis 0～40%, Cortex Magnoliae Officinalis 0～40%, Rhizoma Alismatis 0～40%.
Preferred compositions is following raw materials by weight percent in the said preparation: Radix Trichosanthis 30～80%, Rhizoma Acori Graminei 5～40%, Rhizoma Coptidis 5～40%, Fructus Amomi Rotundus 5～40%.
It prepares as follows: above-mentioned raw materials is added on together in proportion, is ground into the fine powder pill; Perhaps use medicinal ethanol (or water) to decoct 10～120 minutes, filter and obtain extracting solution, be concentrated into driedly, encapsulated or tabletting gets final product; Or extracting solution is concentrated into 1/2 of raw material volume, sterilization bottling then.This product according to for each person every day 1～50 the gram or concentrated solution take for 5～20 milliliters, have the obvious functions of blood sugar effect.
Among the present invention, Radix Trichosanthis and Rhizoma Coptidis have very strong hypoglycemic activity, are the main hypoglycemic activity composition of this product.Rhizoma Acori Graminei and Fructus Amomi Rotundus have the damp and hot effect of removing, and strengthen the function of preparation clearing away damp-heat, and then strengthen the effect that its treatment " is quenched one's thirst ".
The effect that below is this compound product treatment diabetes compares.
The preparation of experiment medicine: Radix Trichosanthis 15g, Rhizoma Acori Graminei 4g, Rhizoma Coptidis 2g, Fructus Amomi Rotundus 3g.Above-mentioned raw materials is added on together, extracted 60 minutes, filter and obtain extracting solution with medicinal reflow of alcohol, 1/2nd (12 milliliters) of simmer down to Chinese crude drug raw material volume, subsequent use.
The preparation of control drug 1 (not containing Fructus Amomi Rotundus): Radix Trichosanthis 15g, Rhizoma Acori Graminei 4g, Rhizoma Coptidis 2g.Above-mentioned raw materials is added on together, extracted 60 minutes, filter and obtain extracting solution with medicinal reflow of alcohol, 1/2nd (10.5 milliliters) of simmer down to Chinese crude drug raw material volume, subsequent use.
The blood sugar lowering experiment: choose 100 of clean level mices, balance was fed after 3 days, tail vein injection alloxan; After 3 days, get blood measuring blood glucose.The mice of choosing blood glucose value and be 10～25 μ mle/mL is a modeling success mice, and then that modeling is successful mice is divided into four groups (10 every group).One group is high sugared model control group, irritates and feeds distilled water (matched group); One group of positive medicine matched group (acarbose) is irritated and is fed acarbose medicine (10mg/Kg); One group is 1 group of control drug, irritates and feeds trial drug (1mL/Kg); One group is compound antihypelipidemic medicine group, irritates and feeds trial drug (1mL/Kg); Continuous irrigation was fed after 30 days, measured blood sugar content (table 1) in the blood.
Table 1, blood sugar lowering experimental result
| ? | Post-prandial glycemia ( μmle/mL） | Fasting glucose ( μmle/mL） | Dead number of elements (only) |
| Normal group | 10.42±1.45 | 5.34±0.91 | 0 |
| High sugared matched group | 23.44±3.22 | 14.33±2.99 | 2 |
| The acarbose group | 15.12±2.67 | 7.56±2.45 | 0 |
| Control drug 1 | 12.24±1.63 | 6.45±1.43 | 0 |
| Drug group | 11.24±1.71 | 5.95±1.34 | 0 |
Experimental result shows that the blood sugar decreasing effect of this product obviously is superior to acarbose, and can blood glucose be dropped to normal basically level; Hypoglycemic effect is better after adding Fructus Amomi Rotundus.
This shows that present technique has following advantage:
1, this compound preparation looses with Rhizoma Acori Graminei and is the basis, behind the interpolation Fructus Amomi Rotundus, and the better effects if of its treatment diabetes.
2, this compound recipe is the basis with the ancient prescription, adds and subtracts according to the ultimate principle of Chinese medicine, and the novel formulation of exploitation is safe.
The specific embodiment
Embodiment one:
Radix Trichosanthis 60g, Rhizoma Acori Graminei 20g, Rhizoma Coptidis 10g, Fructus Amomi Rotundus 10g.Above-mentioned raw materials is added on together, pulverizes, pill, subsequent use.This product has the obvious functions of blood sugar effect according to 50 overcoming usefulness for each person every day.
Embodiment two:
Radix Trichosanthis 20g, Rhizoma Acori Graminei 10g, Rhizoma Coptidis 10g, Fructus Amomi Rotundus 10g, Herba Pogostemonis 10g, Rhizoma Atractylodis 10g, Cortex Magnoliae Officinalis 10g, Semen Coicis 10g, Rhizoma Alismatis 10g.Above-mentioned raw materials is added on together, extracted 60 minutes with medicinal reflow of alcohol, filter and obtain extracting solution, be concentrated into the dried extractum 20g that obtains, encapsulated or tabletting gets final product.This product has the obvious functions of blood sugar effect according to 1 overcoming usefulness for each person every day.
Embodiment three:
Radix Trichosanthis 90g, Rhizoma Acori Graminei 1g, Rhizoma Coptidis 1g, Fructus Amomi Rotundus 1g, Herba Pogostemonis 4g, Semen Coicis 3g.Above-mentioned raw materials is added on together, extracted 60 minutes with medicinal reflow of alcohol, filter and obtain extracting solution, be concentrated into the dried extractum 20g that obtains, encapsulated or tabletting gets final product.This product has the obvious functions of blood sugar effect according to 5 overcoming usefulness for each person every day.
Embodiment four:
Radix Trichosanthis 10g, Rhizoma Acori Graminei 50g, Rhizoma Coptidis 2g, Fructus Amomi Rotundus 2g, Rhizoma Atractylodis 24g, Cortex Magnoliae Officinalis 12g.Above-mentioned raw materials is added on together, and medication water reflux, extract, 60 minutes is filtered and is obtained extracting solution, is concentrated into the half the of former medicine volume, obtains 50 milliliters of concentrated solutions.This product according to for each person every day 5 milliliters take, have the obvious functions of blood sugar effect.
Embodiment five:
Radix Trichosanthis 40g, Rhizoma Acori Graminei 20g, Rhizoma Coptidis 20g, Fructus Amomi Rotundus 10g, Cortex Magnoliae Officinalis 10g.Above-mentioned raw materials is added on together, and medication water reflux, extract, 60 minutes is filtered and is obtained extracting solution, is concentrated into the half the of former medicine volume, obtains 50 milliliters of concentrated solutions.This product according to for each person every day 20 milliliters take, have the obvious functions of blood sugar effect.
Claims (1)
1. the Rhizoma Coptidis compound preparation of the damp and hot tired spleen type diabetes of treatment is characterized in that its raw material is: Radix Trichosanthis 30～80%, Rhizoma Acori Graminei 5～40%, Rhizoma Coptidis 5～40%, Fructus Amomi Rotundus 5～40%; Above-mentioned raw materials is added on together in proportion, is ground into the fine powder pill; Perhaps boiled 10～120 minutes with medicinal ethanol or decocting, filter and to obtain extracting solution, be concentrated into driedly, encapsulated or tabletting gets final product; Or said extracting solution is concentrated into 1/2 of raw material volume, sterilization bottling then.
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| CN103053748B (en) * | 2012-12-31 | 2014-06-18 | 青岛华仁技术孵化器有限公司 | Kudzu vine root fat-reducing sugar-reducing health-care tea and preparation method thereof |
| CN106138701A (en) * | 2016-09-06 | 2016-11-23 | 湖南灼华生物科技有限公司 | A kind of Chinese medicine composition improving damp-heat stagnating in the spleen and its preparation method and application |
| CN113025707A (en) * | 2021-05-19 | 2021-06-25 | 北京中医药大学 | Application of biomarker in preparation of product for diagnosing damp-heat spleen-encumbering type 2 diabetes and kit |
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| CN101513474A (en) * | 2008-02-22 | 2009-08-26 | 北京天科仁祥医药科技有限公司 | Chinese medicinal oral liquid for treating diabetes |
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