CN106138701A - A kind of Chinese medicine composition improving damp-heat stagnating in the spleen and its preparation method and application - Google Patents
A kind of Chinese medicine composition improving damp-heat stagnating in the spleen and its preparation method and application Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a kind of Chinese medicine composition improving damp-heat stagnating in the spleen and its preparation method and application, the effective ingredient of described Chinese medicine composition is prepared from by the crude drug of following weight parts: the Radix Aucklandiae 36 parts, Rhizoma Dioscoreae 10 20 parts, Folium Microcoris paniculatae 15 25 parts, Rhizoma Coptidis 15 parts, Radix Puerariae 8 15 parts, Radix Ophiopogonis 5 10 parts, 10 15 parts of Poria, Rhizoma Atractylodis 1 10 parts, Cortex Magnoliae Officinalis 1 10 parts, Herba Eupatorii 1 10 parts.Described Chinese medicine composition compatibility is reasonable, and all medicines share, and play the effect improving syndrome of dampness-heat stagnating in spleen altogether.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition improving damp-heat stagnating in the spleen and preparation method thereof
And application.
Background technology
Chinese medicine thinks that taste are the foundation of acquired constitution, source of generating QI and blood, is the maincenter of zang-fu differentiation.Taste scholar's Li Dong Yuan
Point out, " disorder of the spleen and stomach caused by internal damage, all kinds of diseases and ailments are by giving birth to ", " all kinds of diseases and ailments are all declined by taste and give birth to also ".Owing to The spleen has the function to transport and transform nutrients, can be by the food of peptic digestion
Further digestion, is converted into cereal nutrient, transports whole body with QI and blood, maintains the vital movement of human body, if therefore taste internal injury and
Weak, it is impossible to biochemical QI and blood, insufficiency of vital energy and blood, then in be not enough to maintain the activity of body and mind, the invasion and attack of the pathogenic factor that is not enough to outward to contend with, past
Toward the generation causing disease.
It is known that summer temperature is higher, modern life rhythm is very fast in addition, the many heresies damp and hot because of sense of old friends, or mistake
Food delicious food savoury, damp and hot interior life, or intemperance of taking food, impairing the spleen and stomach, damp-stagnancy heat-transformation, make middle burnt ascending or descending movement of vital Qi not normal, occur in
Then feel sick tending to vomit, in then distension and fullness in the abdomen, indigestion and loss of appetite, detest greasy, mouth is glutinous and sweet, not well in lower then diarrhea with loose stool；Heat stagnation then generates heat, and mouth sticks
Bitter taste, red tongue, yellow and greasy fur, rapid pulse or moisten number；The tired weight of dampness then limbs, greasy fur, soft pulse；The jaundice of appearance skin is damp and hot strongly fragrant resistance
Middle Jiao, the liver failing to maintain the normal flow of QI, bile is excessive caused.In short, disease sees that gastral cavity abdominal distention is vexed, thirsty few drink, lack of appetite is indigestion and loss of appetite, big loose stool and not
Refreshing, red tongue, yellowish fur；Have also has the tired weight of limbs, indistinctive fever or no relieving of symptom after perspiration, distention and fullness in the abdomen, nausea of feeling sick, body mesh concurrently
Jaundice color is distinct, soft and rapid pulse.These problems all affect the mental status of people and healthy.
Summary of the invention
Based on this, the present invention provides a kind of Chinese medicine composition improving damp-heat stagnating in the spleen.
The concrete technical scheme solving above-mentioned technical problem is as follows:
A kind of Chinese medicine composition improving damp-heat stagnating in the spleen, former by following weight parts of the effective ingredient of described Chinese medicine composition
Material medicine is prepared from: Radix Aucklandiae 3-6 part, Rhizoma Dioscoreae 10-20 part, Folium Microcoris paniculatae 15-25 part, Rhizoma Coptidis 1-5 part, Radix Puerariae 8-15 part, 5-Radix Ophiopogonis
10 parts, Poria 10-15 part, Rhizoma Atractylodis 1-10 part, Cortex Magnoliae Officinalis 1-10 part, Herba Eupatorii 1-10 part.
In certain embodiments, the effective ingredient of described Chinese medicine composition is prepared from by the crude drug of following weight parts:
Radix Aucklandiae 4-6 part, Rhizoma Dioscoreae 13-18 part, Folium Microcoris paniculatae 18-23 part, Rhizoma Coptidis 2-4 part, Radix Puerariae 9-13 part, 6-9 part Radix Ophiopogonis, Poria 11-14
Part, Rhizoma Atractylodis 4-9 part, Cortex Magnoliae Officinalis 4-9 part, Herba Eupatorii 3-8 part.
In certain embodiments, the effective ingredient of described Chinese medicine composition is prepared from by the crude drug of following weight parts:
Radix Aucklandiae 5-6 part, Rhizoma Dioscoreae 15-16 part, Folium Microcoris paniculatae 19-21 part, Rhizoma Coptidis 2-3 part, Radix Puerariae 10-11 part, 7-8 part Radix Ophiopogonis, Poria 12-13
Part, Rhizoma Atractylodis 6-8 part, Cortex Magnoliae Officinalis 6-8 part, Herba Eupatorii 5-6 part.
Another object of the present invention is to provide the preparation method of a kind of Chinese medicine composition improving damp-heat stagnating in the spleen, including with
Lower step:
1) take the Radix Aucklandiae, Rhizoma Dioscoreae, Folium Microcoris paniculatae, Rhizoma Coptidis, Radix Puerariae, Radix Ophiopogonis, Poria, the decoction of Rhizoma Atractylodis magnolia obovata, filter, obtain filtrate；
2) take Herba Eupatorii micro-pan-fried, filter, obtain filtrate；
3) by step 1) and step 2) gained filtrate mixing, be concentrated into thick paste,.
In certain embodiments, step 1) described in the number of times of decoction be 1-3 time.
Another object of the present invention is to provide a kind of Chinese medicine composition preparation for improve damp-heat stagnating in the spleen medicine or
Application in health product.
A kind of Chinese medicine composition improving damp-heat stagnating in the spleen of the present invention and preparation method and application thereof have following excellent
Point and beneficial effect:
1) Chinese medicine composition compatibility of the present invention is reasonable, and all medicines share, and play the effect improving damp-heat stagnating in the spleen altogether, can be effective
Improve gastral cavity abdominal distention vexed, thirsty few drink, lack of appetite is indigestion and loss of appetite, big loose stool and not well, red tongue, yellowish fur, and the tired weight of limbs, fever of the body is not
Raising or no relieving of symptom after perspiration, distention and fullness in the abdomen, nausea of feeling sick, body mesh jaundice color is distinct, the symptom of soft and rapid pulse.
2) preparation method of the present invention, it decocts respectively according to each character of medicinal material, gives full play to each medical material drug effect,
Simply, conveniently, effectively.
Detailed description of the invention
Below with reference to specific embodiment, the present invention will be further described, in order to those skilled in the art are clearer
Solve the present invention, but and be not so limited the present invention.
Embodiment 1
The present embodiment relates to a kind of Chinese medicine composition improving damp-heat stagnating in the spleen, and its effective ingredient is by the crude drug of following weight
It is prepared from: Radix Aucklandiae 5g, Rhizoma Dioscoreae 15g, Folium Microcoris paniculatae 20g, Rhizoma Coptidis 2g, Radix Puerariae 10g, 7g Radix Ophiopogonis, Poria 12g, Rhizoma Atractylodis 6g, Cortex Magnoliae Officinalis
7g, Herba Eupatorii 5g.
The preparation method of the above-mentioned Chinese medicine composition improving damp-heat stagnating in the spleen, comprises the following steps:
1) take the Radix Aucklandiae, Rhizoma Dioscoreae, Folium Microcoris paniculatae, Rhizoma Coptidis, Radix Puerariae, Radix Ophiopogonis, Poria, Rhizoma Atractylodis magnolia obovata decoct 3 times, filter, take filter
Liquid；
2) take Herba Eupatorii micro-pan-fried, filter, take filtrate；
3) by step 1) and step 2) gained filtrate mixing, be concentrated into thick paste (relative density is 1.30-1.35), i.e.
Can.
Embodiment 2
The present embodiment relates to a kind of Chinese medicine composition improving damp-heat stagnating in the spleen, and its effective ingredient is by the crude drug of following weight
It is prepared from: Radix Aucklandiae 3g, Rhizoma Dioscoreae 10g, Folium Microcoris paniculatae 15g, Rhizoma Coptidis 2g, Radix Puerariae 15g, 10g Radix Ophiopogonis, Poria 15g, Rhizoma Atractylodis 10g, Cortex Magnoliae Officinalis
10g, Herba Eupatorii 10g.
The preparation method of the above-mentioned Chinese medicine composition improving damp-heat stagnating in the spleen is with reference to embodiment 1.
Embodiment 3
The present embodiment relates to a kind of Chinese medicine composition improving damp-heat stagnating in the spleen, and its effective ingredient is by the crude drug of following weight
Be prepared from: Radix Aucklandiae 5g, Rhizoma Dioscoreae 18g, Folium Microcoris paniculatae 23g, Rhizoma Coptidis 4g, Radix Puerariae 9g, 6g Radix Ophiopogonis, Poria 11g, Rhizoma Atractylodis 4g, Cortex Magnoliae Officinalis 4g,
Herba Eupatorii 3g.
The preparation method of the above-mentioned Chinese medicine composition improving damp-heat stagnating in the spleen is with reference to embodiment 1.
Hereinafter beneficial effects of the present invention is described further by knot clinical data and model case.
Observing damp-heat stagnating in the spleen type patient, experiment content is as follows:
1, physical data
200 example patients all meet and improves damp-heat stagnating in the spleen pattern of syndrome diagnostic criteria, be randomly divided into treatment group 1, treatment group 2, control
Treatment group 3 and each 50 examples of matched group.Treatment group 1: male 27 examples, female 23 example, age 25-65 year, 42 years old mean age, the course of disease 5 months
To 1 year.Treatment group 2: male 21 examples, female 29 example, age 25-61 year, 39 years old mean age, the course of disease 4 months to 1 year.Treatment group 3:
Man 18 examples, female 32 example, age 24-60 year, 39 years old mean age, the course of disease 5 months to 1 year.Matched group: male 25 examples, female 25 example, year
26-60 year in age, 40 years old mean age, the course of disease 5 months to 1 year.Four groups the aspects such as sex, age, the course of disease without significant difference (P >
0.05), there is comparability.
2, diagnostic criteria main syndromes
Primary symptom: gastral cavity abdominal distention is vexed, thirsty few drink, lack of appetite is indigestion and loss of appetite, big loose stool and not well, red tongue, yellowish fur.
Secondary disease: the tired weight of limbs, indistinctive fever or no relieving of symptom after perspiration, distention and fullness in the abdomen, nausea of feeling sick, body mesh jaundice color is distinct, soft pulse
Number.
Syndrome of dampness-heat stagnating in spleen primary symptom 3 (picture of the tongue is indispensable)；Or primary symptom 2 (picture of the tongue is indispensable), add time disease 2, the most diagnosable.
3, the Chinese and western medicine Disease Diagnosis Standard that assertive evidence relates to is sick
If assertive evidence relates to Chinese and western medicine disease, need to enter by domestic and international domestic generally acknowledged, the up-to-date Chinese and western medicine diagnostic criteria of this disease
Row diagnosis.
4, inclusive criteria
(1) meet warm and accumulate spleen card diagnostic criteria.
(2) if relating to Chinese and western medicine disease patient, the Chinese and western medicine Disease Diagnosis Standard of defined should be met.
(3) according to the age range of the requirement reasonable definition experimenter of clinical trial by stages.II clinic age phase was at 18 years old
Above, less than 65 years old.
(4) signature Informed Consent Form person.
5, exclusion standard
(1) syndrome of dampness-heat stagnating in spleen diagnostic criteria person is not met.
(2) case in medicine sphere of action it is not belonging to.
(3) have and substantially hold concurrently folder syndrome or merge patient.
(4) suckling, gestation or be ready for gestation women.
(5) allergic constitution and to test medicine prescription Chinese medicine allergy sufferers.
(6) severe primary disease and the psychotics such as liver, kidney, hemopoietic system, hormonal system are merged.
(7) state of an illness is critical, it is difficult to effectiveness and safety to new drug make definite estimator.
6, observation index
A, safety observation
A. general health check-up item inspection.
B. blood, urine, feces routine examination.
C. the heart, Liver and kidney function inspection.
D. the untoward reaction being likely to occur.
B, health giving quality are observed
A. the related symptoms of this test requirements document and tongue pulse condition.
B. relevant laboratory parameters.Should be specifically noted that in selection study on syndrome nature, discovery is close with syndrome of dampness-heat stagnating in spleen
Relevant laboratory parameters.
If c. relating to Chinese and western medicine disease, optional index of correlation.
7, Therapeutic Method
Treatment group 1, treatment group 2, treatment group 3 take the Chinese medicine composition described in embodiment 1-3 respectively, and matched group is taken:
Radix Aucklandiae 5g, Rhizoma Dioscoreae 18g, Folium Microcoris paniculatae 23g, Rhizoma Coptidis 4g, Radix Puerariae 9g, 6g Radix Ophiopogonis, Poria 11g, Rhizoma Atractylodis 4g, preparation method is with reference to implementing
Example 1, potion, divided and sooner or later took for 2 times every day.Within 4 weeks, being a course for the treatment of, treatment group 1, treatment group 2, treatment group 3 and matched group all treat 1
The individual course for the treatment of.
8, criterion of therapeutical effect
(1) clinical cardinal symptom disappears, and secondary disease substantially disappears or disappears.
(2) effective: cardinal symptom disappears, and secondary disease disappears substantially.
(3) effective: cardinal symptom substantially alleviates.
(4) invalid: not reach the case of effective standard.
9, therapeutic effect
Four groups treatment 1 the course for the treatment of comparitive study, treatment group 1 (50 example), wherein cure 12 examples (24%), effective 18 examples
(36%), effective 14 examples (28%), invalid 6 examples (12%)；Treatment group 2 (50 example), wherein cures 10 examples (20%), effective 17 examples
(34%), effective 13 examples (26%), invalid 10 examples (20%)；Treatment group 3 (50 example), wherein cures 9 examples (18%), effective 15 examples
(30%), effective 15 examples (30%), invalid 11 examples (22%)；Matched group (50 example), wherein cures 4 examples (8%), effective 8 examples
(16%), effective 11 examples (22%), invalid 27 examples (54%).
Relatively understand: treatment group 1, treatment group 2 and the cure rate for the treatment of group 3, total effective rate are substantially better than matched group, have
Comparability (P < 0.05).In therapeutic process, patient does not has obvious adverse reaction.
Claims (6)
1. the Chinese medicine composition improving damp-heat stagnating in the spleen, it is characterised in that: the effective ingredient of described Chinese medicine composition is by following
The crude drug of weight portion is prepared from: Radix Aucklandiae 3-6 part, Rhizoma Dioscoreae 10-20 part, Folium Microcoris paniculatae 15-25 part, Rhizoma Coptidis 1-5 part, Radix Puerariae 8-15
Part, 5-10 part Radix Ophiopogonis, Poria 10-15 part, Rhizoma Atractylodis 1-10 part, Cortex Magnoliae Officinalis 1-10 part, Herba Eupatorii 1-10 part.
The Chinese medicine composition improving damp-heat stagnating in the spleen the most according to claim 1, it is characterised in that: described Chinese medicine composition
Effective ingredient is prepared from by the crude drug of following weight parts: Radix Aucklandiae 4-6 part, Rhizoma Dioscoreae 13-18 part, Folium Microcoris paniculatae 18-23 part, Rhizoma Coptidis
2-4 part, Radix Puerariae 9-13 part, 6-9 part Radix Ophiopogonis, Poria 11-14 part, Rhizoma Atractylodis 4-9 part, Cortex Magnoliae Officinalis 4-9 part, Herba Eupatorii 3-8 part.
The Chinese medicine composition improving damp-heat stagnating in the spleen the most according to claim 2, it is characterised in that: described Chinese medicine composition
Effective ingredient is prepared from by the crude drug of following weight parts: Radix Aucklandiae 5-6 part, Rhizoma Dioscoreae 15-16 part, Folium Microcoris paniculatae 19-21 part, Rhizoma Coptidis
2-3 part, Radix Puerariae 10-11 part, 7-8 part Radix Ophiopogonis, Poria 12-13 part, Rhizoma Atractylodis 6-8 part, Cortex Magnoliae Officinalis 6-8 part, Herba Eupatorii 5-6 part.
4. a preparation method for the Chinese medicine composition improving damp-heat stagnating in the spleen as described in any one of claim 1-3, its feature
It is, comprises the following steps:
1) take the Radix Aucklandiae, Rhizoma Dioscoreae, Folium Microcoris paniculatae, Rhizoma Coptidis, Radix Puerariae, Radix Ophiopogonis, Poria, the decoction of Rhizoma Atractylodis magnolia obovata, filter, take filtrate；
2) take Herba Eupatorii micro-pan-fried, filter, take filtrate；
3) by step 1) and step 2) gained filtrate mixing, be concentrated into thick paste,.
The preparation method of the Chinese medicine composition improving damp-heat stagnating in the spleen the most according to claim 4, it is characterised in that step 1)
The number of times of described decoction is 1-3 time.
6. the Chinese medicine composition improving damp-heat stagnating in the spleen described in any one of claim 1-3 is being prepared for improving damp-heat stagnating in the spleen
Application in medicine or health product.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007154A (en) * | 2006-01-23 | 2007-08-01 | 金沈蓉 | Orally-taken Chinese medicine for treating syndromes caused by stagnation of damp and heat in spleen and functional dyspepsia |
| CN101982194A (en) * | 2010-11-17 | 2011-03-02 | 西南大学 | Coptis root compound preparation for treating dampness-heat spleen encumbering type diabetes |
| CN103735984A (en) * | 2013-12-20 | 2014-04-23 | 孙丽 | Traditional Chinese medicine for treating spleen disease with syndrome of dampness-heat accumulation in spleen |
| CN105749156A (en) * | 2016-03-11 | 2016-07-13 | 沈宁 | Traditional Chinese medicine composition for treating syndrome of dampness-heat stagnating in spleen and preparation method thereof |
-
2016
- 2016-09-06 CN CN201610805260.5A patent/CN106138701A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007154A (en) * | 2006-01-23 | 2007-08-01 | 金沈蓉 | Orally-taken Chinese medicine for treating syndromes caused by stagnation of damp and heat in spleen and functional dyspepsia |
| CN101982194A (en) * | 2010-11-17 | 2011-03-02 | 西南大学 | Coptis root compound preparation for treating dampness-heat spleen encumbering type diabetes |
| CN103735984A (en) * | 2013-12-20 | 2014-04-23 | 孙丽 | Traditional Chinese medicine for treating spleen disease with syndrome of dampness-heat accumulation in spleen |
| CN105749156A (en) * | 2016-03-11 | 2016-07-13 | 沈宁 | Traditional Chinese medicine composition for treating syndrome of dampness-heat stagnating in spleen and preparation method thereof |
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Application publication date: 20161123 |