CN1618439A - Broad-specturm medicine for treating snake venom poisoning - Google Patents

Abstract

A broad-spectrum Chinese medicine for treating the biting injury of various vipers, carbuncle, subcutaneous ulcer and furuncle is prepared from 27 Chinese-medicinal materials including coptis root, phellodendron bark, scutellaria root, notoginseng, etc. Its advantage is high curative effect.

Description

A kind of Broad-specturm medicine for treating snake venom poisoning

Technical field

The present invention relates to a kind of pharmaceutical composition, particularly a kind of dragon and phoenix Broad-specturm medicine for treating snake venom poisoning.

Technical background

China is located in temperate zone and subtropical zone, and is with a varied topography, and especially south is more suitable for Serpentis class growth and breeding because rainfall is abundant.No matter be mountain area or coastal, the tens of thousands of people is all arranged by venom every year, be engaged in field work person and more subject to the poisonous snake injury.By venom, if early time treatment is improper or do not have easy medicine and carry out first aid, its consequence is hardly imaginable, and it relates to systems such as breathing, circulation, digestion, urinary system, nerve.And most regular hospital seldom is provided with " snakebite section ", therefore makes troubles to the patient.Some is provided with the hospital of " snakebite section ", and its therapeutic scheme is with player's section headed by quiet " venom " serum mostly, although this biological product curative effect is pretty good, also has many practical problems: one needs cold depositing in refrigerator throughout the year.It should cooperate regular nursing staff by the medical practitioner, just can carry out medication in the place that possesses Emergency equipment (as oxygen, Claritin), also must make 20-30 minute skin test earlier before use.False negative or false positive phenomenon also can appear in accidental some patient, not only exist skin test result's error in judgement, have also delayed early treatment's quality time.Its two said preparation needs just can be effective at same toxic venom person.Unsighted or misunderstand poisonous snake kind time-like as the patient, as by main suit's prescribe medicine, not only invalid is " adding poison on the poison " on the contrary, and its consequence will be hardly imaginable.Its three uses said preparation preferably will just have produce effects in 24 hours, then effect is not good enough to treatment middle and advanced stage snakebite.Therefore constraint in time makes troubles for ungetable outlying district patient.Its tetravalence lattice costliness is not suitable for treating light, moderate intoxication patient.It five can not be carried and penetration and promotion.

In view of this, the applicant has applied for a kind of multi-functional antidote for snake bites (number of patent application: 03115316.X).This antidote for snake bites mainly adopts the medicine materials such as medicine material, tubers medicine material, whole grass medicine material and oils and fats mineral of insecticide animal class to carry out the combo preparation, though above-mentioned antidote for snake bites function is many, can control venom, also bite and the treatment of carbuncle, furuncle, furuncle innominate toxic swelling applicable to the poisonous insect bee venom, have broad-spectrum high efficacy, carry and deposit convenient advantage, but blemish in an otherwise perfect thing is can only be as external used medicine, and processing technique is complicated, and cost of material is more expensive.

Summary of the invention

The purpose of this invention is to provide more reasonably dragon and phoenix Broad-specturm medicine for treating snake venom poisoning (being called for short the dragon and phoenix antidote for snake bites) of a kind of combo (compatibility), it has broad-spectrum high efficacy equally, and both oral administrations, but external again, preparation easily, usage is simple, and is easy to carry.

The present invention adopts following technical scheme to realize that its constituent comprises following active princlple (being weight portion)

A group: the medicine material (comprise that some fibre-bearings are more, be difficult for pulverizing and the bigger medicine of volume) of making extractum: Radix Gentianae 5～20, Herba Pteridis Multifidae 10～40, Radix Scutellariae 3～15, Rhizoma Coptidis 3～15, Cortex Phellodendri 3～15, Rhizoma Paridis 3～15, Herba Lobeliae Chinensis (suddenly separating rope) 9～25, Radix Ophiopogonis 10～25, Herba Scutellariae Barbatae 10～40, Herba Hedyotidis Diffusae 10～40, Herba Senecionis Scandentis 15～40, abacus bead (calabazilla) 15～40;

B group: the medicine material of pulverization (comprising some valuable, starch-containing more and frangible medicines): Radix Et Rhizoma Rhei (noiseless tiger) 3～15, Olibanum 6～20, Myrrha 6～20; Radix Pseudostellariae 10～30, Radix Aristolochiae 3～12, Radix Notoginseng 3～10; it bamboo root 6～15; Rhizoma Corydalis 5～10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3～15, the Radix Angelicae Dahuricae 2～10; Bombyx Batryticatus (parched with bran) 1～3; Serpentis (the tail parched with bran of decaptitating) 2～6, Scolopendra, Scorpio (wine is washed the back parched with bran) each 0.6～2, the artificial Calculus Bovis 0.2～0.5.

The present invention adopts the said medicine raw material to carry out formulated in combination, is to have heat clearing and damp drying because of Radix Gentianae, and the eliminating pathogen in the liver effect of fire cures mainly dampness-heat in the liver and gallbladder, and frightened pain is mad dry, diseases such as skin infection; Herba Pteridis Multifidae: subduing swelling and detoxicating, clearing away heat-damp and promoting diuresis, removing heat from blood, hemostasis, (therefore two herbal medicines are the indispensable medicine in the prescription to cure mainly intestinal fire, liver-fire, lung-fire, get its dragon (Radix Gentianae) phoenix (Herba Pteridis Multifidae) two words and constitute " dragon and phoenix antidote for snake bites ", be convenient to memory first, the meaning of expectation " prosperity brought by the dragon and the phoenix " is second arranged).Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri three all have heat clearing away, dampness, the effect of the fire of dispelling, detoxifcation, but that the property of medicine is returned through each is variant, and Radix Scutellariae is longer than the fire that rushes down the part of the body cavity above the diaphragm housing the heart and lungs, Jiao's fire during Rhizoma Coptidis is longer than and rushes down, and Cortex Phellodendri is longer than the fire that rushes down the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and three medicines share more apparent special effect.Rhizoma Paridis, Herba Lobeliae Chinensis (suddenly separating rope), ear are climbed grass, the Herba Hedyotidis Diffusae effect with tool heat-clearing and toxic substances removing, reducing swelling and alleviating pain, relieving stranguria by diuresis, are the general key medicines of grass antidote for snake bites among the people.Herba Senecionis Scandentis: heat-clearing and toxic substances removing, antipruritic cures mainly: erysipelas, furuncle and phyma, eczema etc.Abacus bead (calabazilla): clearing away heat-damp and promoting diuresis, dispelling, collateral-activating cure mainly: rheumatic arthritis, throat pain, traumatic injury etc.Radix Ophiopogonis: eliminating heart-fire, lung moistening, promote the production of body fluid, cure mainly: dry pharynx, thirsty and consumption of body fluid caused by febrile disease, spitting of blood, hematemesis etc.Radix Et Rhizoma Rhei: clearing away heat-fire, blood circulation promoting and blood stasis dispelling, the relieving constipation detoxifcation cures mainly excessive noxious heat, the carbuncle erysipelas.Radix Aristolochiae: circulation of qi promoting, detoxifcation, blood pressure lowering cure mainly: chest and abdomen swelling and pain, carbuncle skin ulcer furuncle is itched and venom.Radix Notoginseng: eliminating stasis to stop pain, be used for various hemorrhage, breast ventral spine pain, carbuncle pain etc.It bamboo root: dispel the wind, pain relieving, detoxifcation, cure mainly rheumatic arthralgia, antidote against snake bite.Olibanum: invigorate blood circulation, detumescence, pain relieving, putrefaction-removing granulation-promoting cures mainly swollen ulcer drug, hard pain.Myrrha: the same Olibanum of nature,taste and action, the blood blood stasis dispelling of relatively loosing.Rhizoma Corydalis: promoting flow of QI and blood, eliminating stasis to stop pain cures mainly the limbs pain that causes because of QI and blood retardance etc.The Radix Angelicae Dahuricae: wind-expelling pain-stopping, detumescence, evacuation of pus, dampness are used for headache due to cold-damp, ulcer sores.Radix Pseudostellariae: tonifying QI to produce body fluid, it is tired to cure mainly deficiency of vital energy god, insufficiency of the spleen lack of appetite, thirsty hyperhidrosis.Bombyx Batryticatus: expelling wind to relieve convulsion, dissipating phlegm and resolving masses cures mainly: convulsion with spasms, laryngopharynx swelling and pain, middle wind headache, aphonia etc.Serpentis: wind-damp dispelling, relieving convulsion, counteracting toxic substances, cure mainly: Fengshi Guanjie is ached, extremity spasm of muscles and vessels etc.Scolopendra: it is relieving convulsion to dispel the wind, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain, treatment of ulcer toxic swelling, snake bite and insect sting.Scorpio (main thin worm): spasmolytic endogenous wind stopping, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain cure mainly: the malignant boil toxic swelling.The artificial Calculus Bovis: it is analgesic to clear away heart-fire, and eliminating phlegm spasmolytic, detoxifcation cure mainly: unconsciousness due to high fever, convulsion with spasms, carbuncle furuncle etc.The Pseudobulbus Bletillae (Rhizoma Bletillae): hemostasis convergence, detumescence and promoting granulation.The purpose that adds the Pseudobulbus Bletillae (Rhizoma Bletillae) among the we, except bringing into play its drug effect that has, main is to utilize " Pseudobulbus Bletillae (Rhizoma Bletillae) " to add water can produce this unique ability of very strong viscosity, makes it " binding agent " as tabletting, simultaneously can be Dermallly affixed when external powder, and make the medicine difficult drop-off.

Why the present invention adopts said medicine to be prepared, and considers that also the toxicity of poisonous snake is divided into the fire-toxin type, pathogenic wind toxic type and wind-fire poison type (being admixture poison again) three kinds.Selected for use Radix Gentianae, Herba Pteridis Multifidae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Rhizoma Paridis, the anxious rope multi-flavor medicines such as (Herba Lobeliae Chinensis) of separating to come clear its heat, separate its poison in the constituent.In various degree pain, swelling are all arranged behind fire-toxin type, the wind-fire poison type venom, the Olibanum in the side, Myrrha, Rhizoma Corydalis, Radix Notoginseng etc. have invigorate blood circulation, the effect of detumescence, blood stasis dispelling, pain relieving.Therapeutic Principle behind the pathogenic wind toxic type venom be expelling wind and relieving convulsion, dispelling wind detoxifcation.Select medicines such as Bombyx Batryticatus, Serpentis, Scolopendra, Scorpio (main thin worm), artificial Calculus Bovis in the prescription for use, be used for that endogenous wind stopping relieving convulsion, arresting convulsion are jerked, the meridian dredging, antidote against snake bite.Manyly behind the venom can cause deficiency of both QI and blood, weakness of the spleen and stomach, dry throat and mouth is selected Radix Pseudostellariae, Radix Ophiopogonis for use in the side, can have an effect that tonifying QI to produce body fluid, nourishing kidney moisturize, and makes the patient be unlikely to cause vigour and body fluid loss because of toxin expelling.Whole prescription both has been suitable for, in fire-toxin type snakebite, be applicable to pathogenic wind toxic type snakebite again, more be applicable to wind-fire poison type snakebite.But while both externals, also oral administration.

Though the present invention has adopted some deleterious medicines own in the prescription raw material.As main thin worm, Scolopendra, Bombyx Batryticatus, Serpentis etc.But after the special processing process of preparing Chinese medicine, toxicity is reduced, the consumption per day of this medicine all is controlled in the safe dose scope simultaneously, therefore is unlikely poisoning at all.

In sum, the medicine that the present invention adopts is except that a part is Chinese crude drug, and all the other all use some wide-spread treating snakebite name medical herbs among the people, and medicine money is very abundant, greatly reduces the cost of medicine.Making principle and technology according to tradition " powder cream sheet ", to wherein a part of costly medicine, starch-containing more and frangible medicine pulverization, all the other some fibre-bearings are more, and the volatile more greatly and not medicine of volume is made extractum, row is dry again behind both mixings, is made into powder, tablet and capsule according to clinical needs at last.The original performance that had both kept medicine has improved the curative effect of medicine again.Compare with pure crude drug preparation, dose greatly reduces.Both can produce the former powerful of medicine with Pseudobulbus Bletillae (Rhizoma Bletillae) powder as excipient (binding agent), can save expense again, and make product become real " pure Chinese medicinal preparation " with other chemical adhesives (as Arabic glue).Not only be fit to the treatment of various snakebites, simultaneously honeybee, Scolopendra, insect-bite being injured carbuncle, cellulitis, furuncle etc. all has better curative effect.Have of many usesly, usage is simple, but not only oral administration, but also external carried and deposited advantages such as convenient.Especially being fit to those does not possess the medical knowledge person uses.For many years, the use result according to hundreds of routine patients shows that its effective percentage can reach more than 90%.If cooperate some other treatments again, as quiet, intramuscular injection and more oral other medicine that antidotes against snake bite, then curative effect is better.

The specific embodiment

Below the specific embodiment of the present invention is described in further detail: the present invention removes when making tablet, adds an amount of distilled water as outside the binding agent, and powder and capsule all do not add any antiseptic and additive.Its function of the antidote for snake bites of three kinds of dosage forms with cure mainly identical, and the active ingredient that can keep former medicine for a long time.

When desiring to make " powder cream type " powder, adopt following technology to make: A is organized medicine chooses and be cut into decoction pieces after clean, put then to add water in the container and exceed the about three centimeters places of powder, dip after about 30 minutes straight fire decoct, and the time add stirring.With high heat, slow fire use in the back of boiling before boiling, keeps little boiling 20-30 minute after, filter only.After medicinal residues decocted with water and keep little boiling 20 minutes, filter was clean again.Merging two slag medicinal liquids leaves standstill and gets the clear liquor reuse fire of living during to concentrated solution at a simmer after 24 hours.Other fine powders of crossing 120 mesh sieves in extractum of after the cooling A being organized and the B group except that " artificial Calculus Bovis " are mixed thoroughly.After super-dry, grind to the powder again and cross 120 mesh sieves, add at last " artificial Calculus Bovis " an amount of and mix thoroughly and be powder.

When desiring to make capsule, get final product every ball net weight 0.4 gram in the large size capsule of the powder of doing with epipodium can being packed into.Pack into the bottle in or aluminium sheet in keep in Dark Place.

When desiring to make tablet, powder can be added an amount of distilled water, make wet granular after, go tabletting again, every net weight 0.5 gram, the sealing of dry back is kept in Dark Place.

Claims (2)

1, a kind of dragon and phoenix Broad-specturm medicine for treating snake venom poisoning is characterized in that its constituent comprises following active princlple (being composition by weight):

A group: the medicine material of making extractum: Radix Gentianae 5～20, Herba Pteridis Multifidae 10～40, Radix Scutellariae 3～15, Rhizoma Coptidis 3～15, Cortex Phellodendri 3～15, Rhizoma Paridis 3～15, Herba Lobeliae Chinensis 9～25, Radix Ophiopogonis 10～25, Herba Scutellariae Barbatae 10～40, Herba Hedyotidis Diffusae 10～40, Herba Senecionis Scandentis 15～40, abacus bead (calabazilla) 15～40;

B group: the medicine material of pulverization: Radix Et Rhizoma Rhei 3～15, Olibanum 6～20, Myrrha 6～20; Radix Pseudostellariae 10～30, Radix Aristolochiae 3～12, Radix Notoginseng 3～10; the bamboo root 6～15 of dying young; Rhizoma Corydalis 5～10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3～15, the Radix Angelicae Dahuricae 2～10; Bombyx Batryticatus (parched with bran) 1～3; Serpentis 2～6, Scolopendra, Scorpio each 0.6～2, the artificial Calculus Bovis 0.2～0.5.

2, Broad-specturm medicine for treating snake venom poisoning according to claim 1 is characterized in that and can also make powder, tablet and three kinds of dosage forms of capsule according to clinical needs.