CN105664056A - Traditional Chinese medicine composition for treating orthopedic diseases, preparing method of traditional Chinese medicine composition and preparation - Google Patents
Traditional Chinese medicine composition for treating orthopedic diseases, preparing method of traditional Chinese medicine composition and preparation Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating orthopedic diseases, a preparing method of the traditional Chinese medicine composition and a preparation. The traditional Chinese medicine composition is prepared from, by weight, 280-320 parts of cortex phellodendri, 100-140 parts of jasmine, 50-60 parts of gypsum, 40-60 parts of cortex moutan, 40-60 parts of radix angelica sinensis, 30-50 parts of radix scutellariae, 30-50 parts of radix paeoniae rubra, 100-120 parts of rheum, 40-60 parts of white peony roots, 40-60 parts of radix curcuma, 40-60 parts of Chinese thorowax roots, 20-50 parts of flos carthami, 30-50 parts of rhizoma cyperi and 30-50 parts of radix geutianae. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is prepared from 14 kinds of traditional Chinese medicine materials such as cortex phellodendri, is reasonable in compatibility and can effectively treat bone fractures, contusion of bones and muscles, joint injuries, acute and chronic soft tissue injuries, joint muscle strain, neck, shoulder, waist and leg pain and other orthopedic diseases, the effective rate reaches 100%, and no toxic or side effect is caused.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of Chinese medicine composition and its preparation method, the preparation for the treatment of Bone injury disease.
Background technology
Bone injury disease is a kind of common disease and frequently-occurring disease, and clinical common Bone injury disease comprises fracture, muscles and bones contusion, joint injury, acute or chronic soft tissue injury, joint muscular strain, neck-shoulder pain, lumbago and leg pain etc. It is reported, there is 1/5 population in China every year in the torment suffering bone fracture disease, seriously affects the quality of life of patient individual and family.
The method of present therapeutic treatment bone fracture disease has doctor trained in Western medicine operation method and the methods for the treatment of that combines with Chinese medicine of traditional Chinese medical science gimmick. Doctor trained in Western medicine operation method is that one treats the good repositioning method of Bone injury disease, but is also injure maximum methods for the treatment of, and patient is painful big, and economical load weight, after fracture operation, the phenomenon of patient's fracture disunion also occurs repeatedly.
The method that traditional Chinese medical science gimmick combines with Chinese medicine has long history in treatment bone fracture is sick, the traditional Chinese medical science is of long standing and well established to the understanding of traditional Chinese medical bone fracture disease, taking organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as theoretical core, the magical curative effect of traditional Chinese medicine in the sick diagnosis and treatment of bone fracture has obtained generally acknowledging of society. The application of activating blood and removing stasis Method in Bone injury disease: promoting blood circulation and removing blood stasis is the important rules for the treatment of of the traditional Chinese medical science is again one of conventional rule of clinical orthopaedics. After human body is damaged, muscles and bones, soft tissue are destroyed, and cause blood to overflow between skin and flesh muscles and bones, blockage of meridian occur, functional activity of QI being not smooth. Show as limbs local swelling, pain, dysfunction. Must first catch during treatment invigorate blood circulation, stagnation resolvation, logical this rule of network, the adjustable body of this method, improves blood circulation, promoting flow of QI and blood, promoting that hemostasis absorbs, thus make the stagnant dissipation of the stasis of blood, swelling is disappeared, and reaches channels sootheing and network vessel quickening, easing joint movement, alleviate pain, the effect that promotion functions recovers.
But the development along with society, traditional Chinese medicine is produced to ignore by people gradually, thus causes the loss of many ancient prescription proved recipes.Nowadays the plaster sold on medical market is multifarious, but medicine form in the analgesic component of all inevitable appearance doctor trained in Western medicine, and then the phenomenon cured the symptoms, not the disease occurs, namely stick plaster at once pain disappear, remove plaster pain as before. Therefore, it is badly in need of a kind of evident in efficacy and orthopedics and traumatology Chinese medicine that can effect a permanent cure.
Summary of the invention
In view of this, the present invention provides a kind of Chinese medicine composition and its preparation method, the preparation for the treatment of Bone injury disease. This Chinese medicine composition compatibility is reasonable, can effectively treat the Bone injury diseases such as fracture, muscles and bones contusion, joint injury, acute or chronic soft tissue injury, joint muscular strain, neck-shoulder pain, lumbago and leg pain, have efficiency to reach 100%. Have no side effect.
In order to realize foregoing invention object, the present invention provides following technical scheme:
The present invention provides a kind of Chinese medicine composition, with parts by weight, obtains by following bulk drug:
Golden cypress 280～320 parts, cape jasmine 100～140 parts, plaster stone 50～60 parts, Tree Peony Bark 40～60 parts, Radix Angelicae Sinensis 40～60 parts, the root of large-flowered skullcap 30～50 parts, the radix paeoniae rubrathe 30～50 parts, rheum officinale 100～120 parts, the root of herbaceous peony 40～60 parts, 40～60 parts, turmeric, radix bupleuri 40～60 parts, 20～50 parts, safflower, rhizoma cyperi 30～50 parts, Radix Gentianae 30～50 parts.
Golden cypress is the bark of rutaceae cork tree or wampee, golden cypress another name bark of a cork tree wood, bark of a cork tree skin, cork tree, and effect of golden cypress is clearing heat and detoxicating, heat-clearing and damp-drying drug, the effect of golden cypress be control damp and hot dysentery, have loose bowels, jaundice, nocturnal emission, pouring are turbid, it is inferior to be with.
Cape jasmine is the fruit of madder wort cape jasmine. The fruit of cape jasmine is traditional Chinese medicine, and the l belonging to Ministry of Health's promulgation criticizes medicine-food two-purpose resource, has and protects the effect such as liver, profit courage, step-down, calmness, hemostasis, detumescence. The diseases such as treatment icterohepatitis, sprain and contusion, hypertension, diabetes it are usually used at tcm clinical practice.
Plaster stone main component is hydrous calcium sulfate. Curing mainly apoplexy fever and chills, heart subinverse gas is frightened to be breathed heavily, and dry tongue is burnt, can not cease, hardness and fullness in the abdomen pain, and evil removing ghost, produces cotton-padded mattress metal-inflicted wound. Except time gas headache body heat, three burnt big heat, skin heat, ties gas, expelling pathogenic factors from muscles by diaphoresis in stomach, only quench one's thirst tired inverse, the sudden and violent gas of abdominal distension, and pharynx heat of panting, also can do bath soup. Cure the wound cold headache as split. Tea is decocted, pain of decaptitating with green onion. Controlling sky capable fanatic, head wind revolves, lactogenesis, wipes tooth benefit tooth. Except stomach energy lung heat, loose cloudy evil, slow spleen benefit gas. Only sun is bright through headache, fever with chills, and day feeds hectic fever, and drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache.
Tree Peony Bark is ranunculaceae peony dry root skin. Originate in the ground such as Anhui, Sichuan, Henan, Shandong. Bitter, pungent, micro-cold, the thoughts of returning home, liver, kidney channel, have the effects such as clearing heat and cooling blood, invigorating blood circulation silt, reducing the asthenic fever.
Radix Angelicae Sinensis, call dry return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis, Radix Angelicae Sinensis body, contain and return that tail, Radix Angelicae Sinensis are bent, Rhizome and root of Udo, its root can be used as medicine, and is one of the most frequently used Chinese medicine. There is benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation, anti-old, immune effect anticancer, anti-ageing.
The root of large-flowered skullcap, another name Radix Scutellariae, tsuchikane tea root are Labiatae Scutellaria per nnial herbs. The root of the root of large-flowered skullcap is used as medicine, bitter, cold in nature, has heat-clearing and damp-drying drug, eliminating fire and detoxication, hemostasis, the effect such as antiabortive. Cure mainly the diseases such as febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, the swollen furuncle sore of carbuncle.
The radix paeoniae rubrathe is the ranunculaceae plant radix paeoniae rubrathe or the dry root of the river radix paeoniae rubrathe.Spring, Qiu Erji excavate, and remove rhizome, fibrous root and silt, dry. Hardship, micro-cold, return Liver Channel. There is effect of clearing heat and cooling blood, promoting blood circulation to remove blood stasis.
Rheum officinale is being collectively referred to as of the perennial plant of multiple polygonaceae Rheum, is also the title of Chinese medicinal materials. Have and attack stagnant, clearing away damp-heat, purging intense heat, cool blood, effect such as the stasis of blood, removing toxic substances of dispelling.
The root of herbaceous peony also claims to spend Chinese herbaceous peony in vain, is Ranunculaceae Chinese herbaceous peony platymiscium. Having long cultivation history in China, have won fame both at home and abroad, it claims to spend Chinese herbaceous peony in vain. Its root can be used as medicine. Perennial herb or undershrub, be born in hillside, the thicket in mountain valley or thick grass. China's most area is all planted. Effect: flat liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating. Dizzy for having a headache, hypochondriac pain, stomachache, four limbs contraction pain, the deficiency of blood is sallow, menoxenia, spontaneous perspiration, night sweat.
Turmeric, has another name called: root tuber of aromatic turmeric, tripod perfume, milli life, Huang Jiang etc. The stasis of blood is broken in turmeric energy promoting the circulation of qi, inducing meastruation to relieve menalgia. Cure mainly chest abdominal distention and pain, shoulder arm numbness pain, pained unbearably, postpartum blood pain, sore tinea onset, menoxenia, amenorrhoea.
Radix bupleuri, another name ground is smoked, mountain dish, mushroom grass, faggot, and nature and flavor are bitter, micro-trembles with fear, and returns liver, gallbladder channel. In having and inducing sweat, effect of soothing the liver liter sun. For cold, fever, alternate attacks of chills and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, uterine prolapse, menoxenia.
Safflower, another name: red indigo plant flower, thorn safflower, composite family, safflower platymiscium, cure mainly promoting blood circulation to restore menstrual flow, blood stasis removing analgesic, contributes to controlling through closing, the stagnant stomachache of dysmenorrhoea, lochia, Obstruction of qi in the chest and cardialgia, the stasis of blood, the chest side of body shouting pain, sore swell and ache.
Rhizoma cyperi is the dry rhizome of sedge nutgrass flatsedge. For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian full pain vexed, swollen, menoxenia, through closing dysmenorrhoea.
Radix Gentianae is root and the stem of Gentianaceae per nnial herb Gentiana manshurica etc., and bitter is cold in nature, the special heat-clearing and damp-drying drug of merit. Its purging the liver of pathogenic fire courage excess fire effect is very strong, and can cease wind only convulsion pain relieving. Under curing mainly heat-clearing and damp-drying drug, purging the liver of pathogenic fire arresting convulsion, jaundice due to damp-heat, urine leaching pain, cloudy swollen pruritus vulvae, humid tropics, the alliteration headache of liver and gall excess fire, conjunctival congestion with pain and swelling of the eye, deaf ear swell, hypochondriac pain bitter taste, pyreticosis convulsion with spasms.
The present invention adopts golden cypress, cape jasmine, plaster stone, Tree Peony Bark, Radix Angelicae Sinensis, the root of large-flowered skullcap, the radix paeoniae rubrathe, rheum officinale, the root of herbaceous peony, turmeric, radix bupleuri, safflower, rhizoma cyperi, this 14 taste Chinese medicine of Radix Gentianae to obtain, compatibility is reasonable, can effectively treat the Bone injury diseases such as fracture, muscles and bones contusion, joint injury, acute or chronic soft tissue injury, joint muscular strain, neck-shoulder pain, lumbago and leg pain, there is efficiency to reach 100%, have no side effect.
As preferably, with parts by weight, this Chinese medicine composition is obtained by following bulk drug:
Golden cypress 284～304 parts, cape jasmine 116～136 parts, plaster stone 53～57 parts, Tree Peony Bark 46～50 parts, Radix Angelicae Sinensis 46～56 parts, the root of large-flowered skullcap 36～46 parts, the radix paeoniae rubrathe 36～46 parts, rheum officinale 104～114 parts, the root of herbaceous peony 46～56 parts, 43～46 parts, turmeric, radix bupleuri 46～49 parts, 24～34 parts, safflower, rhizoma cyperi 34～44 parts, Radix Gentianae 34～44 parts.
Preferably, with parts by weight, this Chinese medicine composition is obtained by following bulk drug:
Golden cypress 284 parts, cape jasmine 136 parts, plaster stone 57 parts, Tree Peony Bark 46 parts, Radix Angelicae Sinensis 46 parts, the root of large-flowered skullcap 46 parts, the radix paeoniae rubrathe 46 parts, rheum officinale 114 parts, the root of herbaceous peony 46 parts, 46 parts, turmeric, radix bupleuri 46 parts, 34 parts, safflower, rhizoma cyperi 34 parts, Radix Gentianae 34 parts.
Present invention also offers the application of this Chinese medicine composition in preparation treatment Bone injury disease medicine;With parts by weight, this Chinese medicine composition is obtained by following bulk drug:
Golden cypress 280～320 parts, cape jasmine 100～140 parts, plaster stone 50～60 parts, Tree Peony Bark 40～60 parts, Radix Angelicae Sinensis 40～60 parts, the root of large-flowered skullcap 30～50 parts, the radix paeoniae rubrathe 30～50 parts, rheum officinale 100～120 parts, the root of herbaceous peony 40～60 parts, 40～60 parts, turmeric, radix bupleuri 40～60 parts, 20～50 parts, safflower, rhizoma cyperi 30～50 parts, Radix Gentianae 30～50 parts.
In embodiments more provided by the invention, Bone injury disease is fracture, muscles and bones contusion, joint injury, acute or chronic soft tissue injury, joint muscular strain or neck-shoulder pain, lumbago and leg pain.
Present invention also offers the preparation method of this Chinese medicine composition a kind of, with parts by weight, this Chinese medicine composition is obtained by following bulk drug:
Golden cypress 280～320 parts, cape jasmine 100～140 parts, plaster stone 50～60 parts, Tree Peony Bark 40～60 parts, Radix Angelicae Sinensis 40～60 parts, the root of large-flowered skullcap 30～50 parts, the radix paeoniae rubrathe 30～50 parts, rheum officinale 100～120 parts, the root of herbaceous peony 40～60 parts, 40～60 parts, turmeric, radix bupleuri 40～60 parts, 20～50 parts, safflower, rhizoma cyperi 30～50 parts, Radix Gentianae 30～50 parts;
Its preparation method is: get bulk drug, adopts water extraction and alcohol precipitation method, obtains Chinese medicine composition.
As preferably, water extraction and alcohol precipitation method is: add soak by water 2～4 times, decocts every time and boil 1～2h, decoct 2 times that boil that water consumption is bulk drug weight every time; Then concentrate to relative density be 1.40～1.45 thick cream, add volume percent be 60%～90% aqueous ethanolic solution precipitate.
In embodiments more provided by the invention, water extraction and alcohol precipitation method is: the water adding 2 times that are equivalent to bulk drug weight, soaks 12～16h, decocts and boils 1h; Add the water of 2 times that are equivalent to bulk drug weight again, decoct and boil 1h, merging filtrate, filter; Then filtrate is concentrated to relative density be 1.40～1.45 thick cream, add volume percent be 70% aqueous ethanolic solution precipitate, filter, filter cake is concentrated to relative density be 1.32～1.35 thick cream.
Present invention also offers a kind of Chinese medicine treating Bone injury disease, comprise Chinese medicine composition provided by the invention.
As preferably, the formulation of Chinese medicine is decoction, paste, tablet, capsule, oral liquid, pill, powder or injection.
In embodiments more provided by the invention, the formulation of Chinese medicine is paste, except Chinese traditional medicine composition beyond the region of objective existence provided by the invention, paste also comprises one or more in stearic acid, mono-glycerides, white vaseline, whiteruss, potassium hydroxide, tween, glycerine or ethyl p-hydroxybenzoate. But group part of paste is not defined in this, those skilled in the art think that feasible paste component is all within protection domain.
Present invention also offers a kind of plaster treating Bone injury disease, this plaster comprises one or more in Chinese medicine composition of the present invention, stearic acid, mono-glycerides, white vaseline, whiteruss, potassium hydroxide, tween, glycerine or ethyl p-hydroxybenzoate.
In embodiments more provided by the invention, the preparation method of plaster of the present invention is: getting potassium hydroxide, to be dissolved in water for subsequent use; Separately get stearic acid, mono-glycerides, white vaseline, whiteruss heating and melting, during when the temperature to 85 DEG C, add potassium hydroxide aqueous solution, stir evenly, below 60 DEG C, add Tween-80, Chinese medicine composition of the present invention and glycerine; Taking ethylparaben adds in said mixture after adding dissolve with ethanol, stirs evenly, makes plaster.
The present invention provides a kind of Chinese medicine composition and its preparation method, the preparation for the treatment of Bone injury disease.With parts by weight, this Chinese medicine composition is obtained by following bulk drug: golden cypress 280～320 parts, cape jasmine 100～140 parts, plaster stone 50～60 parts, Tree Peony Bark 40～60 parts, Radix Angelicae Sinensis 40～60 parts, the root of large-flowered skullcap 30～50 parts, the radix paeoniae rubrathe 30～50 parts, rheum officinale 100～120 parts, the root of herbaceous peony 40～60 parts, 40～60 parts, turmeric, radix bupleuri 40～60 parts, 20～50 parts, safflower, rhizoma cyperi 30～50 parts, Radix Gentianae 30～50 parts. The useful effect that the present invention has is: the present invention adopts golden cypress, cape jasmine, plaster stone, Tree Peony Bark, Radix Angelicae Sinensis, the root of large-flowered skullcap, the radix paeoniae rubrathe, rheum officinale, the root of herbaceous peony, turmeric, radix bupleuri, safflower, rhizoma cyperi, this 14 taste Chinese medicine of Radix Gentianae to obtain, compatibility is reasonable, can effectively treat the Bone injury diseases such as fracture, muscles and bones contusion, joint injury, acute or chronic soft tissue injury, joint muscular strain, neck-shoulder pain, lumbago and leg pain, there is efficiency to reach 100%, have no side effect.
Embodiment
The present invention discloses a kind of Chinese medicine composition and its preparation method, the preparation for the treatment of Bone injury disease, and those skilled in the art can use for reference content herein, and suitable improving technique parameter realizes. Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention. Method and the application of the present invention are described by better embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope, methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
Identification (in order to avoid occurring in the course of processing mixing erroneous judgement with other drug) to medicament composing prescription:
1) substantially (after hybrid medicine is got 10g, entirety breaks into powder) is seen: this product is yellow or brown powder, mildly bitter flavor;
2) micro-sight (discriminating of similar medication): get this product, observe under being placed in microscope (opticmicroscope OM:10 × 40):
Cape jasmine: pericarp membrane class is square; Containing spar cell similar round, or polygon, wall thickness; Various kinds of cell rectangle, cell includes brown thing;
Golden cypress: stone cell similar round, what have is branched, and fiber and surrounding crystal cell form crystal fiber;
Radix Gentianae: yellow powder similar round, has 3 germ pores. Exodermis cell surface sees fusiform, and endodermis cell surface sees rectangle like.
3) plaster proterties: get this product and spread out in the plaster mounting bright brown on paper, there is gloss, the micro-perfume (or spice) of gas, slightly pungent. Every regulation (Chinese Pharmacopoeia version in 2015 annex 1P) relevant under should meeting plaster item
In the Chinese medicine composition for the treatment of Bone injury disease provided by the invention and its preparation method, preparation, raw materials used medicine or auxiliary material all can be buied by market.
Below in conjunction with embodiment, set forth the present invention further:
The preparation of embodiment 1 Chinese medicine composition
Chinese prescription: golden cypress 284 parts; Cape jasmine 136 parts; Plaster stone 57 parts; Tree Peony Bark 46 parts; Radix Angelicae Sinensis 46 parts; The root of large-flowered skullcap 46 parts; The radix paeoniae rubrathe 46 parts; Rheum officinale 114 parts; The root of herbaceous peony 46 parts; 46 parts, turmeric; Radix bupleuri 46 parts; 34 parts, safflower; Rhizoma cyperi 34 parts; Radix Gentianae 34 parts.
Making method: be soaked in the water of 2 times of bulk drug weight after above medicinal material is mixed, ambient temperatare carries out after putting 12-16h (until it is sunken under water) decocting and boils constantly boiling 1h, draw the water again adding 2 times of bulk drug weight after liquid carry out decocting boil constantly boiling 1h after again draw liquid. Using filter paper to filter after being mixed by 2 liquids, the liquid obtaining clarifying light tone is for subsequent use.Liquid after process is placed in rotary evaporation concentrating instrument, keep 120rpm and 120 DEG C concentrate to relative density be 1.40-1.45 thick cream after for subsequent use, wait is cooled to room temperature, add 70% ethanol and make it precipitation, leave standstill, filter, filtrate recycling ethanol, it is decompressed to the thick cream that relative density is 1.32-1.35, for subsequent use.
The preparation of embodiment 2 plaster
Getting potassium hydroxide 6g is dissolved in 200mL water for subsequent use; Separately get stearic acid 140g, mono-glycerides 30g, white vaseline 60g, whiteruss 35mL heating and melting, during when the temperature to 85 DEG C, add potassium hydroxide aqueous solution, stir evenly, Tween-8020mL, the embodiment 1 obtained thick cream of 610g and glycerine 100mL is added below 60 DEG C, taking ethylparaben 2g adds after ethanol dissolves on a small quantity and adds in said mixture, stirs evenly, makes the plaster that total amount is 1000g.
The preparation of embodiment 3 Chinese medicine composition
Chinese prescription: golden cypress 300 parts, cape jasmine 116 parts, plaster stone 53 parts, Tree Peony Bark 48 parts, Radix Angelicae Sinensis 50 parts, the root of large-flowered skullcap 36 parts, the radix paeoniae rubrathe 36 parts, rheum officinale 104 parts, the root of herbaceous peony 50 parts, 45 parts, turmeric, radix bupleuri 49 parts, 30 parts, safflower, rhizoma cyperi 44 parts, Radix Gentianae 44 parts.
Making method: be soaked in the water of 2 times of bulk drug weight after above medicinal material is mixed, ambient temperatare carries out after putting 12-16h (until it is sunken under water) decocting and boils constantly boiling 1h, draw the water again adding 2 times of bulk drug weight after liquid carry out decocting boil constantly boiling 1h after again draw liquid. Using filter paper to filter after being mixed by 2 liquids, the liquid obtaining clarifying light tone is for subsequent use. Liquid after process is placed in rotary evaporation concentrating instrument, keep 120rpm and 120 DEG C concentrate to relative density be 1.40-1.45 thick cream after for subsequent use, wait is cooled to room temperature, add 70% ethanol and make it precipitation, leave standstill, filter, filtrate recycling ethanol, it is decompressed to the thick cream that relative density is 1.32-1.35, for subsequent use.
The preparation of embodiment 4 plaster
Getting potassium hydroxide 6g is dissolved in 200mL water for subsequent use; Separately get stearic acid 140g, mono-glycerides 30g, white vaseline 60g, whiteruss 35mL heating and melting, during when the temperature to 85 DEG C, add potassium hydroxide aqueous solution, stir evenly, Tween-8020mL, the embodiment 3 obtained thick cream of 610g and glycerine 100mL is added below 60 DEG C, taking ethylparaben 2g adds after ethanol dissolves on a small quantity and adds in said mixture, stirs evenly, makes the plaster that total amount is 1000g.
The preparation of embodiment 5 Chinese medicine composition
Chinese prescription: golden cypress 304 parts, cape jasmine 130 parts, plaster stone 55 parts, Tree Peony Bark 50 parts, Radix Angelicae Sinensis 56 parts, the root of large-flowered skullcap 40 parts, the radix paeoniae rubrathe 40 parts, rheum officinale 110 parts, the root of herbaceous peony 56 parts, 43 parts, turmeric, radix bupleuri 48 parts, 24 parts, safflower, rhizoma cyperi 40 parts, Radix Gentianae 40 parts.
Making method: be soaked in the water of 2 times of bulk drug weight after above medicinal material is mixed, ambient temperatare carries out after putting 12-16h (until it is sunken under water) decocting and boils constantly boiling 1h, draw the water again adding 2 times of bulk drug weight after liquid carry out decocting boil constantly boiling 1h after again draw liquid. Using filter paper to filter after being mixed by 2 liquids, the liquid obtaining clarifying light tone is for subsequent use. Liquid after process is placed in rotary evaporation concentrating instrument, keep 120rpm and 120 DEG C concentrate to relative density be 1.40-1.45 thick cream after for subsequent use, wait is cooled to room temperature, add 70% ethanol and make it precipitation, leave standstill, filter, filtrate recycling ethanol, it is decompressed to the thick cream that relative density is 1.32-1.35, for subsequent use.
The preparation of embodiment 6 plaster
Getting potassium hydroxide 6g is dissolved in 200mL water for subsequent use; Separately get stearic acid 140g, mono-glycerides 30g, white vaseline 60g, whiteruss 35mL heating and melting, during when the temperature to 85 DEG C, add potassium hydroxide aqueous solution, stir evenly, Tween-8020mL, the embodiment 5 obtained thick cream of 610g and glycerine 100mL is added below 60 DEG C, taking ethylparaben 2g adds after ethanol dissolves on a small quantity and adds in said mixture, stirs evenly, makes the plaster that total amount is 1000g.
Embodiment 7 clinical application
2013-2014 adopts embodiment 2 plaster external application for curing wrist joint damage 30 example, obtains and is satisfied with curative effect, specific as follows:
1) physical data: wrist joint patient 30 example, wherein man 23 example, female 7 example; Age minimum person 21 years old, the maximum 52 years old; The shortest person of the course of disease 2 days, most elder 18 days.
2) methods for the treatment of: first allow patient's autonomic activities wrist joint. When wrist joints moving to not position or not a position, direction time one or more pain spot occurs, after pressing judgement " Ashi point " by doctor again, namely this posture is kept not move, centered by the most serious pain spot, cover pain spot used is that principle carries out applying ointment or plaster plaster as far as possible, around wrist joint, bandaging is fixed again, every day 1 time, is for 5 times 1 course for the treatment of.
3) observation of curative effect:
Recovery from illness: symptom completely dissolve, wrist joint recovers normal 22 examples without pressure pain point, movable function, accounts for 73%;
Taking a turn for the better: pain relief, wrist joint pressure pain point reduces, movable function obviously improvement person 8 example, accounts for 27%;
Result: this group 30 example is fully effective, has efficiency to be 100%.
Embodiment 8 clinical application
1 clinical data
1.1 physical data are originally organized in 69 examples, man 40 example, female 29 example. Year at age 22-67, average 42.6 years old. The shortest 3d of the course of disease, the longest 35d, average 7d is morbidity when turning round or bend over to bear a heavy burden, and has 42 examples to feel and has " click " sample bullet sound. Time injured and flank pain, lumbar vertebrae all directions limitation of activity. Handle ruling by law and treat pain relief, but still can not free rotation person.
1.2 clinical manifestation 69 examples have all showed flank pain, and unilateral flank pain person 34 example, exacerbation of symptoms when cough, sneeze, pathology occurs to save section in L1～L5～S1. All have degree different force position, waist muscle anxiety, the obvious tenderness of pathology Minor articulus, knocking pain are positive, lumbar vertebrae all directions limitation of activity, and palpation can find that spine is prominent partially askew 41 examples, with other not point-blank. The oriented arm of main suit or sacrococcygeal region Rediating Pain person 24 example. Have because cold wet and wound factor cause pain in the back medical history person 48 example; Waist is stiff, rises with morning and exacerbation of symptoms during rest, remission person 44 example after movable, prominent partially askew person 45 example of X-ray film lesions showed spine, and 69 examples are all without pathology, locally fracture or other osteopathy.
2 methods for the treatment of Example 2 plaster, spread on trouble portion, and get windy mansion, CHENGSHAN acupoint, press massage and press, and make hotness have as far as possible and pass capable sensation up and down along channels and collaterals.
Auxiliary method: manual reduction has reset bad through examination, row manual reduction. Adopt manipulation of massage, rubbing by loosening waist muscle 15min, then adopt left and right oblique traction, patient gets lateral position, the leg being positioned at lower section stretches naturally, the leg hip in the wrong being positioned at top is gone down on one's knees, and patient stands in the face of patient, supports shoulder and the hip of patient side respectively with two elbows, two elbow is exerted oneself simultaneously, do opposite direction to pull, when executing art, can feel the changing of the relative positions in vertebra joint and normal with sound of getting involved, each 1 time of left and right;Advising patient to get ventricumbent position again, and catch the head of a bed with both hands, patient stands in tailstock and padded, two hand-tight hold the two ankle joint top of patient, mention with bed about 45° angle draw, make waist be dorsiflexion shape, when drawing to maximum, force, firmly shake waist downwards, 3 times repeatedly suddenly; Last patient's both hands are puted the palms together before one, and pat waist with little thenar flesh, and rub by loosening.
3 this group for the treatment of result 69 examples, all adopt embodiment 2 plaster treatment, stick rear symptom and namely start to subtract the lighter 29 example, account for 42.0%; Sticking basic in rear symptom 2～4d disappearance, waist is movable normal, but local pain person 28 example when excessively bending over, account for 40.6%; After 5 days, symptom is obviously alleviated, and forces position to release, and slightly limited person 12 example of waist activity, accounts for 17.4%. The equal completely dissolve of symptom is followed up a case by regular visits to, it is possible to participate in normal operation after half month.
Embodiment 9 clinical application
1.1 physical data
82 routine senile backbone joint disease patients, wherein 35 example neck and shoulder pain patient, man 13 example, female 22 example, minimum 52 years old of age, maximum 92 years old, average 62.3 years old; 47 example pain in the waist and lower extremities patients, man 22 example, female 25 example, minimum 50 years old of age, maximum 93 years old, average 67.7 years old. There is obvious inducement person 33 example. Recurrence after operation person 17 example. Without obvious inducement person 32 example. Maximum 56 years of the course of disease, the shortest 35 days. According to patient's the past and present illness history, clinical sign, neck lumbar spine x line sheet finding is made a definite diagnosis, and accurately inquiry medical history and detailed body are looked into is the main method diagnosing this disease. Again can the diagnosis of reference in conjunction with X-ray, CT, MRI. The 82 old patients of example have 66 examples to have x line sheet, and 28 examples have CT, wherein have that 16 examples are handicapped does not have Image-aided to diagnose. More than enumerate case and all meet clinical diagnosis.
1.2 methods for the treatment of:
Adopting embodiment 2 plaster external application complex therapy method, its method divides four steps to carry out.
1.2.1 choose the position of externally applied ointment: choose Ashi point (pain point) and Chinese medicine meridian diagnosis and treatment based on an overall analysis of the illness and the patient's condition acupoint selection more.
Neck and shoulder pain selects: wind pond, hundred labor, big vertebra, Tian Zong. Pain in the waist and lower extremities is selected: in large intestine Yu, Yaoyangkuan (Du 3), waist leg cave, Huantiao, committee, gb 34, therefrom selects 2-3 acupuncture points external application medicine.
1.2.2 cutaneous acupuncture blood-letting puncture is executed: be advisable to slightly oozing blood choosing acupuncture point is beaten gently.
1.2.3 executing cupping: cup on the acupuncture point beaten, be detained 3-5 minute, take off tank, sucking-off l-2mL blood is good.
1.2.4 externally applied ointment: externally applied ointment on the acupuncture point through sterilization. Sticking plaster and within five minutes, start to occur fiber crops slight in various degree, peppery, significant reaction person has the fear similar cold symptoms of cold heating, and this is all that plaster normally reacts. Within 2nd day, having faint yellow rheuminess thing to ooze out, pain malaise symptoms alleviates. 3rd day clean wound, changes plaster. Change plaster every day once in the future. State of an illness the lighter need to paste seven days, and the state of an illness is severe one need more than 15 days relatively. Being labelled to skin wound to heal completely, namely disease fully recovers. Weak or old sick severe one, then need to add Chinese medicine after treatment.
2. efficacy assessment standard and result:
(1) effective: symptom and sign, neck, shoulder, waist, and leg is movable obviously to be improved. (3) invalid: unchanged before and after treatment. The 82 old backbone joint diseases of example, follow up a case by regular visits to 6 months-30 months, average 14.5 months. 35 example neck and shoulder pain, effective 30 examples (85.7%), 5 examples that take a turn for the better (14.3%), always have efficiency to be 100%. 47 example pain in the waist and lower extremities, effective 38 examples (80.9) %, 9 examples that take a turn for the better (19.1%), always have efficiency to be 100%.
The above is only the preferred embodiment of the present invention; it is noted that for those skilled in the art, under the premise without departing from the principles of the invention; can also making some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition, it is characterised in that, with parts by weight, obtain by following bulk drug:
Golden cypress 280～320 parts, cape jasmine 100～140 parts, plaster stone 50～60 parts, Tree Peony Bark 40～60 parts, Radix Angelicae Sinensis 40～60 parts, the root of large-flowered skullcap 30～50 parts, the radix paeoniae rubrathe 30～50 parts, rheum officinale 100～120 parts, the root of herbaceous peony 40～60 parts, 40～60 parts, turmeric, radix bupleuri 40～60 parts, 20～50 parts, safflower, rhizoma cyperi 30～50 parts, Radix Gentianae 30～50 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that, with parts by weight, obtain by following bulk drug:
Golden cypress 284～304 parts, cape jasmine 116～136 parts, plaster stone 53～57 parts, Tree Peony Bark 46～50 parts, Radix Angelicae Sinensis 46～56 parts, the root of large-flowered skullcap 36～46 parts, the radix paeoniae rubrathe 36～46 parts, rheum officinale 104～114 parts, the root of herbaceous peony 46～56 parts, 43～46 parts, turmeric, radix bupleuri 46～49 parts, 24～34 parts, safflower, rhizoma cyperi 34～44 parts, Radix Gentianae 34～44 parts.
3. Chinese medicine composition according to claim 1 and 2, it is characterised in that, with parts by weight, obtain by following bulk drug:
Golden cypress 284 parts, cape jasmine 136 parts, plaster stone 57 parts, Tree Peony Bark 46 parts, Radix Angelicae Sinensis 46 parts, the root of large-flowered skullcap 46 parts, the radix paeoniae rubrathe 46 parts, rheum officinale 114 parts, the root of herbaceous peony 46 parts, 46 parts, turmeric, radix bupleuri 46 parts, 34 parts, safflower, rhizoma cyperi 34 parts, Radix Gentianae 34 parts.
4. according to any one of claims 1 to 3, Chinese medicine composition treats the application in Bone injury disease medicine in preparation.
5. application according to claim 4, it is characterised in that, described Bone injury disease is fracture, muscles and bones contusion, joint injury, acute or chronic soft tissue injury, joint muscular strain or neck-shoulder pain, lumbago and leg pain.
6. the preparation method of a Chinese medicine composition, it is characterised in that, with parts by weight, obtain by following bulk drug:
Golden cypress 280～320 parts, cape jasmine 100～140 parts, plaster stone 50～60 parts, Tree Peony Bark 40～60 parts, Radix Angelicae Sinensis 40～60 parts, the root of large-flowered skullcap 30～50 parts, the radix paeoniae rubrathe 30～50 parts, rheum officinale 100～120 parts, the root of herbaceous peony 40～60 parts, 40～60 parts, turmeric, radix bupleuri 40～60 parts, 20～50 parts, safflower, rhizoma cyperi 30～50 parts, Radix Gentianae 30～50 parts;
Its preparation method is: get described bulk drug, adopts water extraction and alcohol precipitation method, obtains Chinese medicine composition.
7. preparation method according to claim 6, it is characterised in that, described water extraction and alcohol precipitation method is: add soak by water 2～4 times, decocts every time and boils 1～2h, decocts 2 times that boil that water consumption is bulk drug weight every time; Then concentrate to relative density be 1.40～1.45 thick cream, add volume percent be 60%～90% aqueous ethanolic solution precipitate.
8. treat the Chinese medicine of Bone injury disease for one kind, it is characterised in that, comprise Chinese medicine composition according to any one of claims 1 to 3.
9. Chinese medicine according to claim 8, it is characterised in that, the formulation of described Chinese medicine is decoction, paste, tablet, capsule, oral liquid, pill, powder or injection.
10. treat the plaster of Bone injury disease for one kind, it is characterized in that, described plaster comprises one or more in Chinese medicine composition according to any one of claims 1 to 3, stearic acid, mono-glycerides, white vaseline, whiteruss, potassium hydroxide, tween, glycerine or ethyl p-hydroxybenzoate.
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| CN115252743B (en) * | 2022-08-18 | 2024-04-19 | 贵州既济堂药业有限公司 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia |
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| CN115252743A (en) * | 2022-08-18 | 2022-11-01 | 贵州既济堂药业有限公司 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia |
| CN115252743B (en) * | 2022-08-18 | 2024-04-19 | 贵州既济堂药业有限公司 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia |
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