CN104147481B - A kind of antipruritic external medicine composition and preparation method thereof - Google Patents
A kind of antipruritic external medicine composition and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of antipruritic external medicine composition and preparation method thereof.The Chinese medicine composition is prepared from by following Chinese medicine material：The root of fangji, luffa, radix rehmanniae recen, pawpaw, rush, radix glycyrrhizae, akebi, safflower, the fruit of Cherokee rose, the fruit of Chinese magnoliavine, asparagus fern, caulis bambusae in taenian, the root bark of Chinese wolf-berry, great burdock achene, the windproof, dried immature fruit of citron orange, the seed of Oriental arborvitae, the Fructus Sophorae, rhizoma cyperi, Morinda officinalis, raspberry, Asiatic plantain, rose hip, galangal, Semen Hoveniae (Fructus Hoveniae), purslane, fresh Rhizoma Phragmitis, evodia rutaecarpa, the bark of official magnolia, eclipta, cattail pollen, puncture vine, cymose buckwheat rhizome, Herba Saussureae Involueratae, radix bardanae.Chinese medicine composition of the present invention, when being particularly prepared into external preparation, can more effectively release itch caused by allergic, eczema, or mosquito bite and insect bite etc..
Description
Technical field
The present invention relates to drug field, and in particular to a kind of antipruritic external medicine composition and preparation method thereof.
Background technology
Itch onset reason is complicated, and skin has the receptor of gargalesthesia, and is transmitted to brain by nerve endings.Affected tissue
The release of amine can promote gargalesthesia.Scratch because tenderness has itching-relieving action, but promote the more histamines of release, aggravate gargalesthesia, shape
Into itching -- the vicious circle grabbed, cause even more serious skin injury and inflammation.
Allergic is the chief complaint for causing pruitus, and the reason for causing allergic has a lot, and wherein eczema is
A kind of most common anaphylaxis dermatosis, its pathogenesis is：It is caused on the basis of complicated internal factor and extraneous factor
Tardive allergy.But some eczemas are then unrelated with allergy.The change of patient's reaction, be often related to it is many because
Element, some are not clear, still need to be studied from now on.
The traditional Chinese medical science think eczema often because of intemperance of taking food, be addicted to drink or overfeeding is pungent stimulates raw meat to start the product of wind, injure taste, spleen loses
Strong fortune, causes retention of damp-heat in the interior, and diseases caused by external factors rheumatism heat evil, and inside and outside two heresy is mutually fought, and fills in space between skin and muscles, contamination skin hair is this disease.Or because
In poor health, spleen is wet because of failure of skin and muscle to be nourished.Or accumulate long because damp and hot, impairment of yin blood, dryness-transformation life wind are consumed, and blood-deficiency and wind-dry is caused, skin first
It is wrong.
The traditional Chinese medical science is clinically by eczema point：Humidifier fever, blood-deficiency and wind-dry disease.The traditional Chinese medical science advises that humidifier fever eczema patients should be avoided
Drink, coffee, pungent stimulation and fried food, diet should be light, absorbs water fruit vegetable more.Durian, mango, longan, lichee etc.
Belong to hot fruit to eat less, in order to avoid the state of an illness " pouring oil on the fire ".Patient can eat the clearing heat and promoting diuresis such as mung bean, wax gourd, lotus seeds, balsam pear food more
Product.Blood-deficiency and wind-dry disease：Blood-deficiency and wind-dry disease should be noted that high liver fire, diet try one's best it is light based on, eat green vegetables, celery, Hu Luo more
Foretell, it is certain note avoiding face tobacco and wine, while can with the medicines of some recuperating qi-bloods, it is antipruritic moisturize, clearing heat and promoting diuresis.Keep mood
It is happy, should not constipation etc., most important is that autopath's contact allergy of trying not is former.
Allergic western medicine therapy has：
(1) general treatement：The cause of disease is pursued, completely cuts off sensitization source, it is to avoid stimulate again.Focus is removed, whole body chronic disease is treated,
Such as indigestion, intestinal parasitic disease, diabetes, spiritual dysautonomia, shank vein varicose.
(2) constitutional treatment：
1. nonspecific desensitization is treated：Acute or subacute eczema can use 10% calcium gluconae 10ml or 10% thio sulphur
Sour sodium 10ml intravenous injections, 1 time/d；Or 0.25% procaine 20ml add 1~2g of vitamin C be injected intravenously, 1 time/d.
2. glucocorticoid：General not advocate application, notable to acute phase inflammatory and general originator is contemplated that to be taken in short term, such as
20~40mg/d of metacortandracin, can take the circumstances into consideration decrement so that disabling after taking effect.
3. immunomodulator：Freeze dried BCG vaccine (EXTRA-B. C. G), thymosin extrasin, transfer factor, levamisol etc. are can select, to slow
Property eczema, especially gerontal patient is effective.
4. antibiotic：To with bacterium infection, heating, enlargement of lymph nodes person, can select such as erythromycin, Ciprofloxacin for oral administration
Or intramuscular injection penicillin etc..
(3) physics and radiotherapy liquid nitrogen cryotherapy, superficial X-ray or radionuclide (32P or 90Sr) plastering therapy
Deng available for the chronic regional eczema of stadium relatively long with stubbornness.
The drawbacks of hormone medicine：If the heavy dose of hormonal medicaments treatment of long-term or short time, can also cause fat, many
Hair, acne, blood glucose rise, hypertension, sodium retention, oedema, blood potassium reduction, paramenia, osteoporosis, aseptic sclerotin are bad
Extremely, the complication such as gastric and duodenal ulcer.Certain infringement can be also caused to kidney, renal glomerular disease albuminuria is such as aggravated, adds
Glomerulosclerosis, easily cause kidney calcification or calculus, induce or aggravate renal infectious disease, cause low potassium nephrosis etc. again.Can also
Cause a series of metabolisms such as body sugar, protein, fat and Water-Electrolyte disorderly, destroy defence system and the suppression of body
Immune response ability.Patient must also keep anaphylactogen firmly in mind, it is to avoid edible or contact, and the aggravation that arrives.If patient exist
Because using corticoid medicine in therapeutic process, and hormone is generated after dependence, drug withdrawal primary affection knock-on aggravate with
Secondary side effect, can make patient produce very big pain, so it is thorough to reach that the thorough purpose for curing disease of safety needs
Eradicate anaphylactogen.Patient must also keep anaphylactogen firmly in mind, it is to avoid edible or contact, and the aggravation that arrives.
Therefore, allergic caused itch is fundamentally treated, body is still adjusted from inside to outside with Chinese medicine and puts down
Weighing apparatus, improves condition rate and reduction recurrence rate.
The content of the invention
It is an object of the invention to provide a kind of antipruritic external medicine composition；
It is a further object of the present invention to provide a kind of preparation method of antipruritic external medicine composition.
The purpose of the present invention is realized by following technical scheme：
Antipruritic external medicine composition of the present invention, it is prepared from by the raw material of following parts by weight：
4-8 parts of the root of fangji, 8-12 parts of luffa, 6-10 parts of radix rehmanniae recen, 7-11 parts of pawpaw, 4-8 parts of rush, 4-8 parts of radix glycyrrhizae,
3-7 parts of akebi, 6-10 parts of safflower, 6-10 parts of the fruit of Cherokee rose, 6-10 parts of the fruit of Chinese magnoliavine, 4-8 parts of asparagus fern, 6-10 parts of caulis bambusae in taenian, root bark of Chinese wolf-berry 6-
10 parts, 7-11 parts of great burdock achene, windproof 4-8 parts, 4-8 parts of the dried immature fruit of citron orange, 4-8 parts of the seed of Oriental arborvitae, 3-7 parts of the Fructus Sophorae, 6-10 parts of rhizoma cyperi, Morinda officinalis
3-7 parts, 4-8 parts of raspberry, 3-7 parts of Asiatic plantain, 4-8 parts of rose hip, 3-7 parts of galangal, 6-10 parts of Semen Hoveniae (Fructus Hoveniae), purslane 4-8
Part, 6-10 parts of fresh Rhizoma Phragmitis, 4-8 parts of evodia rutaecarpa, 3-7 parts of the bark of official magnolia, 6-10 parts of eclipta, 4-8 parts of cattail pollen, 4-8 parts of puncture vine, cymose buckwheat rhizome
4-8 parts, 2-4 parts of Herba Saussureae Involueratae, 6-10 parts of radix bardanae；
Preferably, it is to be prepared from by the raw material of following parts by weight：
7 parts of the root of fangji, 11 parts of luffa, 7 parts of radix rehmanniae recen, 10 parts of pawpaw, 5 parts of rush, 5 parts of radix glycyrrhizae, 6 parts of akebi, safflower 6
Part, 7 parts of the fruit of Cherokee rose, 7 parts of the fruit of Chinese magnoliavine, 7 parts of asparagus fern, 7 parts of caulis bambusae in taenian, 8 parts of the root bark of Chinese wolf-berry, 8 parts of great burdock achene, windproof 7 parts, 7 parts of the dried immature fruit of citron orange, cypress
Sub- 5 parts of benevolence, 4 parts of the Fructus Sophorae, 7 parts of rhizoma cyperi, 6 parts of Morinda officinalis, 6 parts of raspberry, 4 parts of Asiatic plantain, 5 parts of rose hip, 6 parts of galangal, trifoliate orange
7 parts of chess piece, 5 parts of purslane, 9 parts of fresh Rhizoma Phragmitis, 7 parts of evodia rutaecarpa, 6 parts of the bark of official magnolia, 7 parts of eclipta, 7 parts of cattail pollen, 7 parts of puncture vine, Jin Qiao
5 parts of wheat, 2 parts of Herba Saussureae Involueratae, 9 parts of radix bardanae.
The following is the crude drug source and primary efficacy of Chinese medicine preparation of the present invention：
The root of fangji：For menispermaceous plants Fourstamen Stephania Root Stephania tetrandra S.Moore dry root.Autumn excavates,
Clean, remove tertia, shine to half-dried, segment, individual big person rip cutting again, dry.【Nature and flavor and channel tropism】Hardship, trembles with fear.Return bladder, lung channel.
【Function is with curing mainly】Wind-expelling pain-stopping, inducing diuresis for removing edema.For arthralgia pain due to rheumatism, oedema tinea pedis, difficult urination, eczema sore.
Luffa：For the dimension pipe of cucurbitaceous plant sponge gourd Luffa cylindrica (L.) Roem. dry mature fruit
Beam.Summer, two season of autumn fruit maturation, pericarp turn yellow, it is internal pluck when withered, remove crust and pulp, clean, dry, remove kind
Son.【Nature and flavor and channel tropism】It is sweet, put down, return lung, stomach, Liver Channel.【Function is with curing mainly】Wind-dispelling, dredging collateral, promoting blood circulation, lower breast.Arrested for numbness pain
Contraction, distending pain in the chest and hypochondrium, alactation, acute mastitis swells and ache.
Radix rehmanniae recen：For scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch. fresh or dried root.
Autumn excavates, except removing LU, fibrous root and silt, using fresh herb；Or slowly bakee glutinous rehmannia to about most probably dry.The former practises title " freshly
It is yellow ", the latter, which practises, claims " radix rehmanniae recen ".【Nature and flavor and channel tropism】It is sweet, tremble with fear.The thoughts of returning home, liver and kidney channel.【Function is with curing mainly】Clearing heat and cooling blood, yin-nourishing
Promote the production of body fluid.For thermal man's ying blood, febrile virulent maculae, hematemesis and epistaxis, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder constipation, fever due to yin deficiency, hectic fever due to yin
Burdock heat, Heat Diabetes.
Pawpaw：Drying for rosaceous plant chaenomeles lagenaria Chaenomeles speciosa (Sweet) Nakai is closely ripe
Fruit.Summer, two season of autumn fruit it is greenish-yellow when harvest, put and scalded in boiling water to crust canescence, double of vertical profile, dried.【Nature and flavor are with returning
Through】Acid, temperature.Return liver, the spleen channel.【Function is with curing mainly】Stimulate the circulation of the blood and cause the muscles and joints to relax, stomach dampness elimination.Ache again for arthritis with fixed pain caused by dampness contraction waist and knees joint acid
Pain summer-heat and damps are vomited and diarrhoea, convulsion contraction pain, tinea pedis oedema.
Rush：For rush family plant rush Juncus effusus L. drying stem marrow.Late summer to autumn extracts
Stem, is dried, and takes out stem marrow, and reason is straight, is bundled into wisp.【Nature and flavor and channel tropism】It is sweet, light, it is slightly cold.The thoughts of returning home, lung, small intestinl channel.【Function with
Cure mainly】Clearing away the heart-fire, diuresis.For vexed insomnia, the puckery pain of oliguria, aphthae.
Radix glycyrrhizae：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
Inflate Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root and rhizome.Spring, season in autumn two excavation is removed
Fibrous root, is dried.【Nature and flavor and channel tropism】It is sweet, put down.The thoughts of returning home, lung, spleen, stomach.【Function is with curing mainly】Invigorate the spleen and benefit qi, it is clearing heat and detoxicating, dispel
Phlegm and relieving cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction
Anxious pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.【Note】Should not be same with marine alga, Beijing spurge root, Knoxia valerianoide, the root of gansui, lilac daphne
With.
Akebi：For plants of Lardizabalaceae akebi Akebia quinata (Thunb.) Decne., threeleaf akebia Akebia
Trifoliata (Thunb.) Koidz. or akebia trifoliata varaustralis Akebia trifoliata (Thunb.) Koidz.var.australis
(Diels) Rehd. drying rattan.Autumn harvests, and intercepts stem, removes withe, dries in the shade.【Nature and flavor and channel tropism】Hardship, trembles with fear.Return
The heart, small intestine, bladder warp.【Function is with curing mainly】Inducing diuresis for treating strangurtia, relieving restlessness that clears away heart-fire, stimulate the menstrual flow lower breast.For stranguria, oedema, vexed urine is red,
Aphthae, Amenorrhea breast is few, damp and hot numbness pain.
Safflower：Flower is dried for feverfew safflower Carthamus tinctorius L..Summer flower by xanthochromia it is red when adopt
Pluck, dry in the shade or dry.【Nature and flavor and channel tropism】It is pungent, temperature.The thoughts of returning home, Liver Channel.【Function is with curing mainly】Invigorate blood circulation, blood stasis removing analgesic.For
Amenorrhea, dysmenorrhoea, lochia , abdominal lump of mass in abdomen, chest impediment and cardialgia, stasis of blood, chest side of body shouting pain, injury from falling down, sore swell and ache curative.
The fruit of Cherokee rose：For rosaceous plant fruit of Cherokee rose Rosa laevigata Michx. dry mature fruit.10~November
Harvest, dry, except deburring when fruit maturation reddens.【Nature and flavor and channel tropism】It is sour, sweet, puckery, put down.Return kidney, bladder, large intestine channel.【Work(
Can be with curing mainly】Astringent sperm contracting urine, curing metrorrhagia and leukorrhagia, relieving diarrhea with astringents.For emission and spermatorrhea, enuresis frequent micturition, under uterine bleeding band, protracted dysentery and diarrhea.
The fruit of Chinese magnoliavine：For magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. drying and ripening
Fruit.Practise and claim " fructus schisandrae ".Plucked during autumn fruit maturation, dry or dried after steaming, remove carpopodium and impurity.【Nature and flavor with
Channel tropism】It is sour, sweet, temperature.Return lung, the heart, kidney channel.【Function is with curing mainly】Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.For void of coughing long
Breathe heavily, emission, enuresis frequent micturition, endless diarrhea, spontaneous sweating, injury thirst, Heat Diabetes, palpitation and insomnia.
Asparagus fern：For liliaceous plant asparagus fern Asparagus cochinchinensis (Lour.) Merr. dried root.
Autumn, the excavation of season in winter two, clean, remove stem foot and fibrous root, put and boil or steam in boiling water to the saturating heart, crust is removed while hot, clean, do
It is dry.【Nature and flavor and channel tropism】Sweet, hardship, trembles with fear.Return lung, kidney channel.【Function is with curing mainly】Nourishing yin to moisten dryness, clearing lung-heat is promoted the production of body fluid.For dryness of the lung dry cough,
Pertussis phlegm is sticked, soreness of waist and knee joint, osteopyrexia and fever, Heat Diabetes, pyreticosis Tianjin wound, dry throat and mouth, dry constipation of intestines.
Caulis bambusae in taenian：For grass bambusa breviflora Munro Bambusa tuldoides Munro, major part allusion quotation bamboo Sinocalamus
Beecheyanus (Munro) McClure var.pubescens P.F.Li or henon bamboo Phyllostachys nigra
(Lodd.) the drying intermediate layer of Munro var.henonis (Mitf.) Stapf ex Rendle stalk.Whole year can adopt
System, takes fresh stem, removes crust, slightly viridant intermediate layer is spread into strand, or chips, and ties up bunchy, it is cloudy in.The former
Claim " scattered caulis bambusae in taenian ", the latter claims " neat caulis bambusae in taenian ".【Nature and flavor and channel tropism】It is sweet, it is slightly cold.Return lung, stomach, the heart, gallbladder channel.【Function is with curing mainly】Clearly
Thermalization phlegm, relieving restlessness, preventing or arresting vomiting.For phlegm-heat cough, courage fire holds phlegm under the arm, palpitate with fear not peaceful, vexed insomnia, middle wind phlegm fan, aphasia with stiff tongue, stomach
Heat vomiting, pernicious vomiting, fetal irritability.
The root bark of Chinese wolf-berry：For matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lycium barbarum
L. dry root skin.Root is excavated at the beginning of spring or after autumn, is cleaned, is stripped root skin, dry.【Nature and flavor and channel tropism】It is sweet, tremble with fear.Return lung, liver,
Kidney channel.【Function is with curing mainly】Cool blood is except steaming, clearing lung-heat fall fire.For deficiency of Yin hectic fever, hectic fever due to yin night sweat, cough with lung heat spits blood, bleeding from five sense organs or subcutaneous tissue,
Heat Diabetes.
Great burdock achene：For feverfew burdock Arctium lappa dry mature fruit.Fruit is harvested during autumn fruit maturation
Sequence, is dried, and lays fruit, removes impurity, then dry.【Nature and flavor and channel tropism】Pungent, hardship, trembles with fear.Attach to the lung and stomach meridians.【Function is with curing mainly】
Dispelling wind and heat from the body, facilitaing lung promoting eruption, relieving sore-throat of detoxifying.For anemopyretic cold, coughing with a lot of sputum, measles, rubella, abscess of throat, mumps is red
Poison, carbuncle sore tumefacting virus.
It is windproof：For umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk. drying
Root.The root of scape plant is not taken out in spring, the excavation of season in autumn two, removes fibrous root and silt, dries.【Nature and flavor and channel tropism】It is pungent, sweet, tepor.
Return bladder, liver, the spleen channel.【Function is with curing mainly】Expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion.For cold headache, arthralgia pain due to rheumatism, rubella
Itch, lockjaw.
The dried immature fruit of citron orange：For rutaceae bitter orange Citrus aurantium L. and its variety or sweet orange Citrus
Sinensis Osbeck drying young fruit.5~June, collected from the fruit fallen, removes impurity, and crosscutting from middle part is two halves, is dried
Or low temperature drying, smaller directly dries or low temperature drying.【Nature and flavor and channel tropism】Bitter, pungent, acid, is slightly cold.Returns spleen, stomach.【Function
With curing mainly】Relieving stagnant Qi disperse accumulations, resolving sputum dissipates ruffian.For internal stagnation, feeling of fullness distending pain, weight after rush down dysentery suffers from constipation, the resistance of phlegm stagnant gas, chest
Numbness, accumulation of pathogens in chest, visceral organ ptosis.
The seed of Oriental arborvitae：For cupressaceae plant arbor-vitae Platycladus orientalis (L.) Franco dry mature kernal.
Autumn, season in winter two harvesting mature seed, dry, remove kind of a skin, collect benevolence.【Nature and flavor and channel tropism】It is sweet, put down.The thoughts of returning home, kidney, large intestine
Through.【Function is with curing mainly】Mental-tranquilization, relaxes bowel, hidroschesis.For deficiency of YIN-blood, dysphoria insomnia, palpitation and severe palpitation, intestinal dryness is just
It is secret, night sweat due to yin deficiency.
The Fructus Sophorae：For legume Chinese scholartree Sophora japonica L. dry mature fruit.Winter harvests, and removes impurity,
Dry.【Nature and flavor and channel tropism】Hardship, trembles with fear.Return liver, large intestine channel.【Function is with curing mainly】Clearing heat-fire, cooling blood and hemostasis.For intestines heat just
Blood, hemorrhoid swell bleeding, liver heat headache, dizziness hot eyes.
Rhizoma cyperi：For sedge nutgrass flatsedge Cyperus rotundus L. dry rhizome.Autumn excavates, and sing the hair palpus,
Put and dried after slightly boiling or steam in boiling water thoroughly, or directly dry after burning.【Nature and flavor and channel tropism】Pungent, slight bitter, micro-sweet, put down.Return liver, spleen,
Tri-jiao channel.【Function is with curing mainly】Soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain,
Swollen breasts, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is vexed, turgor pain, irregular menstruation, closed dysmenorrhea.
Morinda officinalis：For madder wort Morinda officinalis Morinda officinalis How dry root.Whole year can adopt
Dig, clean, remove fibrous root, shine to 6 seventy percent dry, gently beat flat, dry.【Nature and flavor and channel tropism】It is sweet, pungent, tepor.Return kidney, Liver Channel.
【Function is with curing mainly】Kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.For impotence and seminal emission, uterus cold infertile, irregular menstruation, few abdomen crymodynia, rheumatism
Numbness pain, muscles and bones impotence.
Raspberry：For rosaceous plant rubus chingii Hu Rubus chingii Hu dry fruit.Early summer fruit is by green
Harvested when becoming greenish-yellow, remove stalk, leaf, put in boiling water and slightly scald or slightly steam, taken out, dried.【Nature and flavor and channel tropism】Sweet, acid, temperature.Return
Liver, kidney, bladder warp.【Function is with curing mainly】Supplementing the kidney to control the nocturnal contracting urine, nourishes the liver to improve visual acuity.For emission and spermatorrhea, enuresis frequent micturition, impotence is early
Let out, mesh is secretly dim-sighted.
Asiatic plantain：For plantago plant Chinese herbaceous peony Plantago asiatica L. or ordinary building Plantago depressa
Willd. drying herb.Summer excavates, and removes silt, dries.【Nature and flavor and channel tropism】It is sweet, tremble with fear.Return liver, kidney, lung, small intestinl channel.
【Function is with curing mainly】Reducing fever and causing diuresis is treating stranguria, eliminating the phlegm, cool blood, removing toxic substances.For puckery pain of heat gonorrhea, oedema oliguria, summer heat damp diarrhea, phlegm heat is coughed
Cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Rose hip：Rose family undershrub umbrella spends rose (scientific name：Rosa maximowicziana Regel) fruit.Quilt
European Countries are considered as " treatment scurvy specific drug "；There is the title of " vitamin record holder ".【Nature and flavor and channel tropism】Return liver；Spleen；
Stomach；Bladder warp.【Function is with curing mainly】Reinforcing spleen to promote digestion；Promoting blood circulation for regulating menstruation；Astringe the lung to stop cough.For indigestion；Poor appetite；Gastral cavity abdomen is swollen
Pain etc..
Galangal：For zingiberaceous plant galangal Alpinia officinarum Hance dry rhizome.Adopted at the beginning of autumn late summer
Dig, remove the scale of fibrous root and residual, clean, segment is dried.【Nature and flavor and channel tropism】It is pungent, heat.Returns spleen, stomach.【Function and master
Control】Warm stomach preventing or arresting vomiting, eliminating cold to stop pain.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
Semen Hoveniae (Fructus Hoveniae)：For Rhamnaceae (Rhamnaceae) plant trifoliate orange chess (Hovenia dulcis Thunb.) drying and ripening
Plant.Alias honey raisin tree, manna, tree honey, cockspur, day rattan chicken feet, the inflexible, semen hoveniae of spine etc..The yin-nourishing of this product energy, promote the production of body fluid, moisturize,
Quench the thirst, cool blood.The traditional Chinese medical science thinks there is heat-clearing, diuresis, relieving alcoholism, cures mainly drunk, dysphoria with smothery sensation, thirsty, vomiting, difficulty in urination and defecation etc.
Disease；Its infructescence axle can treat rheumatism；Carpopodium can stomach invigorating, enrich blood, for nourish enrich blood；Leaf does not go out for stillborn foetus；Leaf liquid is used to remove
Body odour.
Purslane：For portulacaceous plant purslane Portulaca oleracea L. dry aerial parts.Summer, autumn
Two seasons harvested, and removed undesirable root and impurity, cleaned, and slightly steamed or were dried after scalding.【Nature and flavor and channel tropism】Acid, trembles with fear.Return liver, large intestine channel.【Work(
Can be with curing mainly】It is clearing heat and detoxicating, cooling blood and hemostasis, stop dysentery.For toxic-heat and blood stasis, carbuncle swells treat sore, eczema, erysipelas, snake bite and insect sting, just
Blood, hemorrhoid blood, metrostaxis.
Reed rhizome：For grass reed Phragmites communis Trin. fresh or dry rhizome.It is annual equal
It can excavate, remove bud, fibrous root and membranaceous leaf, using fresh herb or dry.【Nature and flavor and channel tropism】It is sweet, tremble with fear.Attach to the lung and stomach meridians.【Function and master
Control】Clearing heat-fire, promotes the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis.For pyreticosis polydipsia, cough with lung heat, lung carbuncle pyemesis, stomach hot vomiting,
Puckery pain of heat gonorrhea.
Evodia rutaecarpa：For rutaceae evodia rutaecarpa Euodia rutaecarpa (Juss.) Benth., Shi Hu Euodia
Rutaecarpa (Juss.) Benth.var.officinalis (Dode) Huang or thin hair evodia rutaecarpa Euodia
Rutaecarpa (Juss.) Benth.var.bodinieri (Dode) Huang drying almost ripe fruit.8~November fruit still
When not ftractureing, fruit branch is cut, is dried or low temperature drying, except impurity such as debranching, leaf, carpopodiums.【Nature and flavor and channel tropism】Pungent, hardship, heat；Have
Mild toxicity.Return liver, spleen, stomach, kidney channel.【Function is with curing mainly】Eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For jueyin headache, cold hernia
Stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal distention vomits acid regurgitation, Diarrhoea.
The bark of official magnolia：For Magnoliacea plant bark of official magnolia Magnolia officinalis Rehd.et Wils. or Magnolia bilola
Magnolia offinalis Rehd.et Wils.var.biloba Rehd.et Wils. drying dry hide, root skin and branch
Skin.4~June strips, root skin and branch skin Directly Dried in Shadow；Dry hide put in boiling water it is micro- boil after, bank up dark and damp place, " sweating " to inner surface
When becoming puce or sepia, steam soft, take out, be rolled into tubular, dry.【Nature and flavor and channel tropism】It is bitter, pungent, temperature.It is returns spleen, stomach, lung, big
Intestines are passed through.【Function is with curing mainly】Eliminating dampness dissolving phlegm, lower gas removes full.For in humidity hysteresis wound, abdominal swelling and diarrhea, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm
Drink is breathed with cough.
Eclipta：For feverfew Eclipta prostrata Eclipta prostrata L. dry aerial parts.Tap, shine when the flowers are in blossom
It is dry.【Nature and flavor and channel tropism】Sweet, acid, trembles with fear.Return kidney, Liver Channel.【Function is with curing mainly】It is nourishing liver and kidney, cooling blood and hemostasis.For the deficiency of liver-yin and kidney-yin,
Tooth mobility, poliosis, dizziness and tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, metrostaxis, outside
Hinder bleeding.
Cattail pollen：For Typhaceae plant raupo cattail Typha angustifolia L., typha orientalis Typha
Orientalis Presl or congener dry pollen.The yellow male inflorescence on summer harvesting cattail's spike top, dries rear rolloff,
Sieve takes pollen.After clip male flower, dry, as the pollen with male flower, as POLLEN TYPHAE CUM STAMEN.【Nature and flavor and channel tropism】It is sweet, flat.Return
Liver, pericardium channel.【Function is with curing mainly】Hemostasis, stagnation resolvation is treating stranguria.For spitting blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, uterine bleeding, traumatism and bleeding, Amenorrhea is led to
Through chest and abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.
Puncture vine：For zygophyllaceae plant puncture vine Tribulus terrestris L. dry mature fruit.Autumn fruit into
Plant is tapped when ripe, is dried, fruit is laid, impurity is removed.【Nature and flavor and channel tropism】Pungent, hardship, tepor；It is slightly poisonous.Return liver warp.【Work(
Can be with curing mainly】Flat liver solution strongly fragrant, promoting blood circulation by removing wind, improving eyesight is antipruritic.For dizziness of having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract,
Rubella itch.
Cymose buckwheat rhizome：For polygonaceae plant cymose buckwheat rhizome Fagopyrum dibotrys (D.Don) Hara dry rhizome.Winter adopts
Dig, except stem and fibrous root is lost, clean, dry.【Nature and flavor and channel tropism】It is micro-pungent, puckery, it is cool.Return lung is passed through.【Function is with curing mainly】It is clearing heat and detoxicating,
Apocenosis dissolving stasis.For lung carbuncle pyemesis, dyspnea and cough due to lung-heat, acute tonsillitis is swollen and ache.
Herba Saussureae Involueratae：This strain Uygur nationality conventional crude drugs.For feverfew Herba Saussureae Involueratae Saussurea
Involucrata (Kar.et Kir.) Sch.Bip. dry aerial parts.Summer, season in autumn two harvest when the flowers are in blossom, it is cloudy in.【Property
Taste】Uygur medicine：Property, two grades damp and hot.The traditional Chinese medical science：Slight bitter, temperature.【Function is with curing mainly】Uygur medicine：Invigorating kidney, promoting blood circulation, strengthening the bones and muscles,
Trophic nerve, dysregulation body fluid.For rheumatic arthritis, arthralgia, lung cold cough, kidney and cold and pain in the lower abdomen, leukorrhea mistake
It is many etc..The traditional Chinese medical science：Warming kidney and enhancing yang, expelling wind and eliminating dampness restores menstrual flow and invigorates blood circulation.For rheumatism numbness pain, rheumatoid arthritis, cold and pain in the lower abdomen,
Irregular menstruation.
Radix bardanae：For feverfew burdock Arctium lappa dried roots.The root of excavation more than 2 years, is washed between October
Only dry.【Nature and flavor and channel tropism】Pungent, hardship, trembles with fear.Return lung, the heart channel of Hang-Shaoyin.【Function is with curing mainly】Wind-dispelling heat, detumescence poison.Control wind toxin edema of the face, head
Dizzy, throat heat is swollen, dentalgia, and cough is quenched one's thirst, ulcer sore scabies.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and this method is
Extracted using the alcohol reflux of water extraction or 40-80% concentration expressed in percentage by volume.Specific preparation method is as follows：
Scheme one：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, often
Secondary extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is 1.10-1.25's when filtrate is concentrated into 70-80 DEG C
Clear cream, produces active component.
Scheme two：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, often
Secondary extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is 1.05-1.20's when filtrate is concentrated into 70-80 DEG C
Clear cream, adds ethanol, and it is 40-70% to make alcohol content, stands 12-24 hours, filtration, and filtrate is concentrated into relatively close at 70-80 DEG C
The medicinal extract for 1.10-1.25 is spent, active component is produced.
Scheme three：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is medicinal material total amount
4-10 times, extraction time is 1-4 hours, merges extract solution, is filtered, and relative density is 1.10- when filtrate is concentrated into 60-80 DEG C
1.25 medicinal extract, produces active component.
Antipruritic external medicine composition of the present invention, can be made with pharmaceutically acceptable carrier combination
Various conventional external preparations, such as liniment, lotion, tincture, finish, paste, (soft) paste, pulvis.
The pharmaceutically acceptable carrier of the present invention includes but is not limited to following：
Diluent：Distilled water, ethanol etc..
Cosolvent：The polyalcohols such as glycerine, sorbierite.
Preservative：Benzoic acid, sodium benzoate, propionic acid, parabens, ethyl-para-hydroxybenzoate etc..
Oleaginous base：Vaseline, liquid paraffin, lanolin, beeswax, animal oil, vegetable oil, glycerin monostearate,
Octadecyl alcolol etc. and its mixture,
Water-soluble base：Glycerine, sodium alginate, carbopol resin, starch gelatin, methylcellulose, carboxymethyl cellulose
Plain sodium, polyethylene glycol, polyvinyl alcohol.
Transdermal enhancer：Cutin moisturizing diuretin, pyrrolones derivative, linoleic acid, laruyl alcohol, tween, dodecyl front three
Base ammonium bromide, dodecyl sodium sulfate, lauryl sodium sulfate, menthol, Laurocapram (azone) etc..
For example, it can be prepared as various common dosage forms by one of following method：
Method 1：Liniment
Take scheme one one of to the gained active component of scheme three, add liniment and often use auxiliary material, routinely prepared by production method
Obtain liniment of the present invention.
Above-mentioned liniment often includes one of diluent, preservative, cosolvent, transdermal enhancer or whole with auxiliary material.
Method 2：Tincture
Active component obtained by taking scheme 1-3, by the customary preparation methods of tincture, is made the tincture of Chinese medicine composition of the present invention
Agent.
Method 3：Ointment
Active component obtained by taking scheme 1-3, by the customary preparation methods of ointment, is made the soft of Chinese medicine composition of the present invention
Paste.
Method 4：Pulvis
Whole raw medicinal materials are taken, are cleaned, crushes, produces pulvis of the present invention.
Allergic its etiology and pathogenesis of card is ferritic insufficiency of vital energy and blood, and weakened defensive QI, the heresy of chill is taken advantage of a weak point in opponent's defence and people, attacks fleshy exterior
It is caused.The method used in treatment adjusts battalion, cold dispelling dispelling wind and arresting itching to enrich blood.If any the product of clearind deficient heat a small amount of Nei Rezekejia,
Should be based on the invigorating the spleen tonifying Qi and blood to quality valetudinarian, invalid.The present invention is with radix rehmanniae recen, rush, asparagus fern, caulis bambusae in taenian, the root bark of Chinese wolf-berry, burdock
Son, luffa, safflower are all monarch drug in a prescription, dispelling wind and heat from the body, facilitaing lung promoting eruption, clearing heat and cooling blood, invigorate blood circulation and removing toxic substances, can be relieved dizziness, high fever, infantile convulsions, epilepsy, etc. only
Itch, but can eliminating toxic send an expedition against, for stubbornness accumulate it is deep long wet poison have an itch, it is the most suitable with it；With the root of fangji, pawpaw, windproof, trifoliate orange
Real, rose hip is ministerial drug, is stimulated the circulation of the blood and cause the muscles and joints to relax, stomach dampness elimination, relieving stagnant Qi disperse accumulations, it is intended to which the knot of promoting the circulation of qi gut purge stomach is warm, to regulating gastointestinal,
Clear away the dampness and heat and accumulate the root of product；The seed of Oriental arborvitae, Morinda officinalis, raspberry, eclipta, Herba Saussureae Involueratae, rhizoma cyperi, galangal, evodia rutaecarpa, wood
The logical, Fructus Sophorae, Asiatic plantain, Semen Hoveniae (Fructus Hoveniae), purslane, fresh Rhizoma Phragmitis, cymose buckwheat rhizome, radix bardanae, the fruit of Cherokee rose, the fruit of Chinese magnoliavine, the bark of official magnolia, cattail pollen, puncture
Lamb's-quarters is assistant, nourishing liver and kidney, warming kidney and enhancing yang, stagnation of QI due to dyspepsia, expelling wind and eliminating dampness, eliminating cold to stop pain, flat liver solution strongly fragrant, promoting blood circulation by removing wind；Radix glycyrrhizae is
And medicine.The wind in interior appearance can be ceased entirely, can lead to the gas of lung and large intestine, clear gastrointestinal retention is washed, and wind-repellent itching-relieving dissipates poison, and sample is simultaneous
Turn round and look at, all medicine phases coordinate, itching-relieving efficacies are extremely strong.
A kind of external medicine composition for analgesic that the present invention is provided has advantages below：
1st, the Chinese medicine composition that the present invention is provided can effectively treat allergic particularly pruitus caused by eczema, can show
Write and mitigate pruritis.Compared with common western medicine group, cure-remarkable-effectiveness rate of the present invention is up to 100%, and curative effect is extremely notable, hence it is evident that better than existing
There is western medicine scheme.
2nd, the external medicine composition that the present invention is provided is for treating a variety of causes not allergic caused skin scabies of name
When itching, due to the affected part that can go directly, and the efficacy of a drug is sufficient, the residence time is long, proves through clinical usage, cure-remarkable-effectiveness rate of the present invention reaches
90%, itch can be substantially eliminated within a short period of time, reduce patient suffering.
3rd, it is of the invention to cannot be only used for itch caused by allergic, eczema, for treating skin caused by mosquito bite and insect bite
Skin itch effect equally extremely substantially, it is outer apply it is latter as can be antipruritic in half a minute, it is red and swollen after 20 minutes to disappear.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate
The present invention rather than limitation of the present invention.The present invention is belonged to according to the simple modifications that the essence of the present invention is carried out to the present invention
Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
The liniment of embodiment 1
Weigh root of fangji 7g, luffa 11g, radix rehmanniae recen 7g, pawpaw 10g, rush 5g, radix glycyrrhizae 5g, akebi 6g, safflower 6g,
Fruit of Cherokee rose 7g, fruit of Chinese magnoliavine 7g, asparagus fern 7g, caulis bambusae in taenian 7g, root bark of Chinese wolf-berry 8g, great burdock achene 8g, windproof 7g, dried immature fruit of citron orange 7g, seed of Oriental arborvitae 5g, the Fructus Sophorae
4g, rhizoma cyperi 7g, Morinda officinalis 6g, raspberry 6g, Asiatic plantain 4g, rose hip 5g, galangal 6g, Semen Hoveniae (Fructus Hoveniae) 7g, purslane 5g, fresh reed
Root 9g, evodia rutaecarpa 7g, bark of official magnolia 6g, eclipta 7g, cattail pollen 7g, puncture vine 7g, cymose buckwheat rhizome 5g, Herba Saussureae Involueratae 2g, radix bardanae 9g, are used
40% alcohol reflux is extracted 3 times, and each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, 4 times, and extraction time difference 4 is small
When, 2 hours, 1 hour, merge extract solution, filtering, relative density is 1.25 medicinal extract when filtrate concentrates 60 DEG C, plus purified water is extremely
Gross weight is 2 times of medicinal material gross weight, adds 0.1% sodium benzoate, 0.05% methyl hydroxybenzoate, mixes, and packing is produced
Liniment of the present invention.
The liniment of embodiment 2
Weigh root of fangji 4g, luffa 8g, radix rehmanniae recen 6g, pawpaw 7g, rush 4g, radix glycyrrhizae 4g, akebi 3g, safflower 6g, gold
Cherry 6g, fruit of Chinese magnoliavine 6g, asparagus fern 4g, caulis bambusae in taenian 6g, root bark of Chinese wolf-berry 6g, great burdock achene 7g, windproof 4g, dried immature fruit of citron orange 4g, seed of Oriental arborvitae 4g, the Fructus Sophorae
3g, rhizoma cyperi 6g, Morinda officinalis 3g, raspberry 4g, Asiatic plantain 3g, rose hip 4g, galangal 3g, Semen Hoveniae (Fructus Hoveniae) 6g, purslane 4g, fresh reed
Root 6g, evodia rutaecarpa 4g, bark of official magnolia 3g, eclipta 6g, cattail pollen 4g, puncture vine 4g, cymose buckwheat rhizome 4g, Herba Saussureae Involueratae 2g, radix bardanae 6g, add water
Extract 3 times, three amount of water are respectively equivalent to 12 times of medicinal material gross weight, 8 times, 6 times, each extraction time distinguish 3 hours, 2
Hour, 1 hour, merge extract solution, filter, relative density is 1.20 clear cream when filtrate is concentrated into 70 DEG C, adds ethanol, makes to contain
Alcohol amount is 40%, stands 24 hours, filtration, and filtrate is concentrated into the medicinal extract that relative density when filtrate is concentrated into 70 DEG C is 1.10, plus
It is 3 times of medicinal material gross weight to enter purified water ad pond om, produces liniment of the present invention.
The paste of embodiment 3
Weigh root of fangji 80g, luffa 120g, radix rehmanniae recen 100g, pawpaw 110g, rush 80g, radix glycyrrhizae 80g, akebi 70g,
It is safflower 100g, fruit of Cherokee rose 100g, fruit of Chinese magnoliavine 100g, asparagus fern 80g, caulis bambusae in taenian 100g, root bark of Chinese wolf-berry 100g, great burdock achene 110g, windproof
80g, dried immature fruit of citron orange 80g, seed of Oriental arborvitae 80g, Fructus Sophorae 70g, rhizoma cyperi 100g, Morinda officinalis 70g, raspberry 80g, Asiatic plantain 70g, rose hip
80g, galangal 70g, Semen Hoveniae (Fructus Hoveniae) 100g, purslane 80g, fresh Rhizoma Phragmitis 100g, evodia rutaecarpa 80g, bark of official magnolia 70g, eclipta 100g, Pu
Yellow 80g, puncture vine 80g, cymose buckwheat rhizome 80g, Herba Saussureae Involueratae 40g, radix bardanae 100g, extracting in water 3 times, three times amount of water is respectively medicine
12 times, 8 times, 6 times of material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extract solution, are filtered, filter
Relative density is 1.10 clear cream when liquid is concentrated into 80 DEG C, standby.
Stearic acid 2g, vaseline 12g, lanolin 10g, glyceryl stearate 4g, hexadecanol 10g are weighed, 85 DEG C are heated to,
Stir evenly, it is standby as oil phase；Another to take glycerine 16g, ethyl-para-hydroxybenzoate 0.3g, lauryl sodium sulfate 3g, bay nitrogen is tall and erect
Ketone 3g, adds above-mentioned medicinal extract, and water use regulation makes oil, the common 150g of water two-phase, as aqueous phase, is heated to 90 DEG C, after all dissolving,
Constant temperature is stirred evenly to 85 DEG C；Oil phase is slowly added into aqueous phase, puts in refiner and stirs, is cooled down, is solidified, packing produces cream of the present invention
Agent.
The paste of embodiment 4
Weigh root of fangji 4g, luffa 12g, radix rehmanniae recen 6g, pawpaw 11g, rush 4g, radix glycyrrhizae 8g, akebi 3g, safflower 10g,
Fruit of Cherokee rose 6g, fruit of Chinese magnoliavine 10g, asparagus fern 4g, caulis bambusae in taenian 10g, root bark of Chinese wolf-berry 6g, great burdock achene 11g, windproof 4g, dried immature fruit of citron orange 8g, seed of Oriental arborvitae 4g,
Fructus Sophorae 7g, rhizoma cyperi 6g, Morinda officinalis 7g, raspberry 4g, Asiatic plantain 7g, rose hip 4g, galangal 7g, Semen Hoveniae (Fructus Hoveniae) 6g, purslane 8g,
Fresh Rhizoma Phragmitis 6g, evodia rutaecarpa 8g, bark of official magnolia 3g, eclipta 10g, cattail pollen 4g, puncture vine 8g, cymose buckwheat rhizome 4g, Herba Saussureae Involueratae 4g, radix bardanae
6g, is extracted 2 times, each concentration of alcohol is respectively 80%, 60%, and each ethanol consumption is respectively medicinal material total amount with alcohol reflux
10 times, 8 times, extraction time is respectively 4 hours, 3 hours, merges extract solution, is filtered, relative density is when filtrate is concentrated into 80 DEG C
1.10 medicinal extract, it is standby.
Stearic acid 3g, vaseline 16g, lanolin 12g, glyceryl stearate 5g, hexadecanol 10g are weighed, 85 DEG C are heated to,
Stir evenly, it is standby as oil phase；Another to take glycerine 12g, ethyl-para-hydroxybenzoate 0.2g, lauryl sodium sulfate 3g, bay nitrogen is tall and erect
Ketone 4g, adds above-mentioned medicinal extract, and water use regulation makes oil, the common 130g of water two-phase, as aqueous phase, is heated to 90 DEG C, after all dissolving,
Constant temperature is stirred evenly to 85 DEG C；Oil phase is slowly added into aqueous phase, puts in refiner and stirs, is cooled down, is solidified, packing produces cream of the present invention
Agent.
The tincture of embodiment 5
Weigh root of fangji 8g, luffa 8g, radix rehmanniae recen 10g, pawpaw 7g, rush 8g, radix glycyrrhizae 4g, akebi 7g, safflower 6g, gold
Cherry 10g, fruit of Chinese magnoliavine 6g, asparagus fern 8g, caulis bambusae in taenian 6g, root bark of Chinese wolf-berry 10g, great burdock achene 7g, windproof 8g, dried immature fruit of citron orange 4g, seed of Oriental arborvitae 8g, the Fructus Sophorae
It is 3g, rhizoma cyperi 10g, Morinda officinalis 3g, raspberry 8g, Asiatic plantain 3g, rose hip 8g, galangal 3g, Semen Hoveniae (Fructus Hoveniae) 10g, purslane 4g, fresh
Reed rhizome 10g, evodia rutaecarpa 4g, bark of official magnolia 7g, eclipta 6g, cattail pollen 8g, puncture vine 4g, cymose buckwheat rhizome 8g, Herba Saussureae Involueratae 2g, radix bardanae 10g,
Extracting in water 2 times, amount of water is respectively 12 times of medicinal material gross weight, 10 times twice, twice extraction time be respectively 3 hours, it is 2 small
When, merge extract solution, filter, relative density is 1.25 clear cream when filtrate is concentrated into 70 DEG C, standby；Qinghuo reagent, plus 85% second
Alcohol is diluted to every 100ml equivalent to crude drug gross weight 10g, produces tincture.
The tincture of embodiment 6
Weigh root of fangji 7g, luffa 8g, radix rehmanniae recen 10g, pawpaw 10g, rush 4g, radix glycyrrhizae 8g, akebi 6g, safflower 6g,
Fruit of Cherokee rose 10g, fruit of Chinese magnoliavine 7g, asparagus fern 4g, caulis bambusae in taenian 10g, root bark of Chinese wolf-berry 8g, great burdock achene 7g, windproof 8g, dried immature fruit of citron orange 7g, seed of Oriental arborvitae 4g, Chinese scholartree
It is angle 7g, rhizoma cyperi 7g, Morinda officinalis 3g, raspberry 8g, Asiatic plantain 4g, rose hip 4g, galangal 7g, Semen Hoveniae (Fructus Hoveniae) 7g, purslane 4g, fresh
Reed rhizome 10g, evodia rutaecarpa 7g, bark of official magnolia 3g, eclipta 10g, cattail pollen 7g, puncture vine 4g, cymose buckwheat rhizome 8g, Herba Saussureae Involueratae 2g, radix bardanae 6g,
Extracting in water 2 times, each amount of water is respectively equivalent to 12 times of medicinal material gross weight, 10 times, and each extraction time is respectively 3 small
When, 2 hours, merge extract solution, filtration, filtrate is concentrated into the clear cream that relative density at 80 DEG C is 1.05, adds ethanol, make containing alcohol
Measure as 70%, stand 12 hours, filtration, relative density is 1.25 medicinal extract when filtrate is concentrated into 70 DEG C, standby；Qinghuo reagent, plus
70% ethanol is diluted to every 100ml equivalent to crude drug gross weight 10g, produces tincture.
The pulvis of embodiment 7
Weigh root of fangji 7g, luffa 11g, radix rehmanniae recen 7g, pawpaw 10g, rush 5g, radix glycyrrhizae 5g, akebi 6g, safflower 6g,
Fruit of Cherokee rose 7g, fruit of Chinese magnoliavine 7g, asparagus fern 7g, caulis bambusae in taenian 7g, root bark of Chinese wolf-berry 8g, great burdock achene 8g, windproof 7g, dried immature fruit of citron orange 7g, seed of Oriental arborvitae 5g, the Fructus Sophorae
4g, rhizoma cyperi 7g, Morinda officinalis 6g, raspberry 6g, Asiatic plantain 4g, rose hip 5g, galangal 6g, Semen Hoveniae (Fructus Hoveniae) 7g, purslane 5g, fresh reed
Root 9g, evodia rutaecarpa 7g, bark of official magnolia 6g, eclipta 7g, cattail pollen 7g, puncture vine 7g, cymose buckwheat rhizome 5g, Herba Saussureae Involueratae 2g, radix bardanae 9g, only
Choosing, crushes, produces pulvis of the present invention.
Clinical treatment is summarized
Itch clinical data caused by 1 treatment eczema
1.1 general information
84 eczema patients are our hospital's outpatient service and inpatient, are randomly divided into two groups, treatment group 42, male 28,
Women 14,20~72 years old age；Control group 42, male 26, women 16,18~68 years old age.Two groups in age, property
Not, it is statistically analyzed in terms of the course of disease, parting, there was no significant difference (P>0.05), with comparativity.
1.2 clinical manifestation
1.2.1 position is originated
Skin damaged is with starting 46 of four limbs, starting 18 of trunk, starting 8 of Head And Face, whole body 12.
1.2.2 skin damaged is distributed
With trunk four limbs involvement be main person 49, whole body affected individual 12, using four limbs involvement as main person 13, Head And Face and
Trunk affected individual 3, with Head And Face and four limbs involvement for main person 1, using trunk involvement as main person 2, with facial and breast by
Tire out for main person 1, using neck and trunk as main affected individual 3.
1.2.3 parting limitation eczema 18, universal eczema 66；Acute eczema 16, subacute eczema 4, slowly
Property eczema 64.
1.2.4 skin damaged feature
All patients are respectively provided with the multifarious feature of eczema.Patients during acute stage skin damaged is with erythema, papule, papulo-vesicle, erosion
Based on, boundary owes clear, and most of patient is symmetric, and has and oozes out tendency or ooze out substantially.Subacute stage lesions of patients with
Papule, scratch, incrustation, based on the scales of skin that peel off, show as a variety of damaging and depositing.Chronic phase skin damaged using patch, lichenification, the scales of skin that peel off as
Main, boundary is clear, in brownish red or grey, pigmentation, rough surface, infiltrate in plump skin damaged or periphery may occur in which it is red
The acute lesions such as spot, papule, papulo-vesicle.There is the infringement of each phase simultaneously in some patientss, each phase patient have different degrees of itch with
And dry skin.
1.3 treatment
1.3.1 treatment packet
Treatment group：The traditional Chinese medicine for external application of the embodiment of the present invention 1, applies affected part, twice daily, the course for the treatment of 1 week.
Control group：According to different skin damaged types, the external preparation treatment of selection different dosage forms.3% boron can be given at sepage
Give package treatment and block itch-vicious circle of scratching, liver mossization model in acid solution or physiological saline soak, the position often scratched
Enclose it is less give local block therapy, dry skin person, which gives, applies NMF, and concurrent infection gives topical antibiotic ointment.
1.3.2 efficacy result
Compare the t compared using paired data mean in the measurement data group of this clinical research to examine, compare use between group
The t that two sample averages compare is examined, and enumeration data uses x2Examine, ranked data are examined with Ridit, and all continuous datas are adopted
WithRepresent, statistical procedures are completed using SPSS13.0 softwares.
Two groups of cure-remarkable-effectiveness rates are through x2Examine, P<0.05, there is significant difference, treatment group's curative effect is substantially better than control group.It is shown in Table
1。
1 two groups of Clinical efficacy comparisons of table
Note：Compared with control group, * P<0.05.
1.4 conclusion
Eczema patient and the puzzlement of heated and wet two kinds of disease and evils.On the one hand patient has excess fire, but because physical function is dull,
So that liver fails to play the function of catharsis toxin expelling, internal heat toxin is just excreted from a big young waiter in a wineshop or an inn.As a result have to transfer from
Pore is discharged, if microcirculqtory system is not good enough or chosure of pores, toxin will be gathered in vivo.When accumulation is to certain degree, or eat
After the food of some sensitization, the skin disease of eczema etc will occur.Secondly, in addition to skin problem, damp and hot person also has chest
Abdominal distension is vexed not to relax, constipation or the illness such as diarrhea, oliguresis be helvolus.Chinese medicine composition of the present invention, is especially formed into external application
During preparation, disease institute can be directly penetrated into, it is rapid to eliminate or alleviate pruritis.Clinical observation result is proved：The present invention and control group
There is different degrees of improvement degree to itch caused by eczema or various symptoms, but the therapeutic effect of the present invention is better than control group,
And with significant difference (P<0.05).Clinical observation result is pointed out：Scabies caused by external medicine composition treatment eczema of the present invention
Effect of itching is good, effect is fast, price is low, Small side effects, better than prior art.
2 treatment anaphylaxis itch clinical datas
2.1 general information
50 are out-patient, wherein man 28, female 21；Average age 35 years old (13~55 years old), average course of disease 3
My god.Wherein drug allergy 4, contact dermatitis 15, anaphylactogen is because failing to understand 31.
2.2 clinical main performances
Unexpected onset, skin damaged is based on the performance of wheal, erythema or papule, violent itch.
2.3 treatment method
The traditional Chinese medicine for external application of the embodiment of the present invention 2 is given, affected part, twice daily, the course for the treatment of 1 week is applied.
2.4 efficacy results, are shown in Table 2
Table 2 treats allergic clinical efficacy
2.5 conclusion
50 patients received hormone and (or) antihistamine drug treatment before external medication of the present invention is received,
The course for the treatment of is more than 3 days, but curative effect is undesirable.After being treated using external preparation of the present invention, next day itch disappears, skin on the 3rd
Rash disappears；Most of patient substantially all disappearance of symptom after 1 week.Clinical observation result is proved：The present invention is to caused by a variety of causes
Pruitus has different degrees of improvement degree, and it is rapid to work, and therapeutic effect is preferable.
Model case
1st, certain is thanked, 35 years old, man.Main suit's pruitus, is many using four limbs, starts to be dispersed in whole body, increases later by slabbing,
Pole is itched, and yellow water is flowed after scratching, and no heating, diet is still good, is slept unreal, and stool and urine is normal, and tongue nature is normal, yellow and greasy fur, arteries and veins Chen Xian
Count accurately.Examine as eczema itch.Give the liniment of the embodiment of the present invention 1 and smear affected part after 2 weeks, do not have recurrence, fully recover.
2nd, beam, 58 years old, man.The visible erythema of main suit's skin, swelling, papule, acute pruritus, with tired burnout, constipation,
Scanty drak urine.Examine as allergic skin, give 3 paste application affected part of the embodiment of the present invention after 2 weeks, do not there is recurrence, fully recover.
3rd, what certain, women, 26 years old.Patient main suit over nearly 2 months it is facial blow to the wind after very itch unbearably, then there is size not
Deng fash, skin turgor, vexed, Lock-out after wind sheltering, again and again, multiple hospitals of once seeking medical advice take chlorpheniramine, cease this
Sensitizing drug 2 weeks is without any effect.Facial swelling is looked into, there is slight dimly visible fash, pale tongue, small and weak pulse, it is believed that ferritic gas
The deficiency of blood is weak, experiences allergic caused by cold-evil.Using 4 paste affected part of exterior coating of the embodiment of the present invention 2 weeks, then cold wind was contacted without recurrence
Itch, is judged to recovery from illness.
4th, Zhao, 39 years old, male.Patient main suit suffers from high blood pressure and heart disease usually, activity then palpitation greatly.Closely
To winter and season in late autumn, as long as to outdoor activity, there is the papule differed in size in facial, neck and both hands, mutually touch within 2 years
Close, lip and Dual-eyelid edema, local scorching hot, phlegm are itched when serious, and wind sheltering is cold and heat can die away.Indagation disease neck face dissipates
Rash is existing, both hands because not exposing no fash appearance, body is become thin, language is humble, tongue nature is light red, small and wiry pulse, it is believed that ferritic
Contained in the weak, fire of deficiency type, be affected by the cold and send out allergic.Applied 2 weeks, fully recovered outside using the tincture of the embodiment of the present invention 5 according to arteries and veins card.
5th, Xian, 10 years old, male, summer was stung to obtain after the red blister of whole body, the outer tincture of the painting embodiment of the present invention 6 by mosquito, at once
Antipruritic, sense of discomfort is disappeared, and the phlycten that mosquito stings after 20 minutes is vanished from sight.
Although above having made to retouch in detail to the present invention with general explanation, embodiment and experiment
State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (7)
1. a kind of antipruritic external medicine composition, it is characterised in that it is prepared from by the raw material of following parts by weight：It is anti-
Own 4-8 parts, 8-12 parts of luffa, 6-10 parts of radix rehmanniae recen, 7-11 parts of pawpaw, 4-8 parts of rush, 4-8 parts of radix glycyrrhizae, 3-7 parts of akebi,
6-10 parts of safflower, 6-10 parts of the fruit of Cherokee rose, 6-10 parts of the fruit of Chinese magnoliavine, 4-8 parts of asparagus fern, 6-10 parts of caulis bambusae in taenian, 6-10 parts of the root bark of Chinese wolf-berry, great burdock achene
7-11 parts, windproof 4-8 parts, 4-8 parts of the dried immature fruit of citron orange, 4-8 parts of the seed of Oriental arborvitae, 3-7 parts of the Fructus Sophorae, 6-10 parts of rhizoma cyperi, 3-7 parts of Morinda officinalis, cover basin
Sub- 4-8 parts, 3-7 parts of Asiatic plantain, 4-8 parts of rose hip, 3-7 parts of galangal, 6-10 parts of Semen Hoveniae (Fructus Hoveniae), 4-8 parts of purslane, fresh Rhizoma Phragmitis 6-
10 parts, 4-8 parts of evodia rutaecarpa, 3-7 parts of the bark of official magnolia, 6-10 parts of eclipta, 4-8 parts of cattail pollen, 4-8 parts of puncture vine, 4-8 parts of cymose buckwheat rhizome, Tianshan Mountains
2-4 parts of saussurea involucrata, 6-10 parts of radix bardanae.
2. Chinese medicine composition according to claim 1, it is characterised in that it is prepared from by the raw material of following parts by weight
's：7 parts of the root of fangji, 11 parts of luffa, 7 parts of radix rehmanniae recen, 10 parts of pawpaw, 5 parts of rush, 5 parts of radix glycyrrhizae, 6 parts of akebi, 6 parts of safflower, gold
7 parts of cherry, 7 parts of the fruit of Chinese magnoliavine, 7 parts of asparagus fern, 7 parts of caulis bambusae in taenian, 8 parts of the root bark of Chinese wolf-berry, 8 parts of great burdock achene, windproof 7 parts, 7 parts of the dried immature fruit of citron orange, the seed of Oriental arborvitae 5
Part, 4 parts of the Fructus Sophorae, 7 parts of rhizoma cyperi, 6 parts of Morinda officinalis, 6 parts of raspberry, 4 parts of Asiatic plantain, 5 parts of rose hip, 6 parts of galangal, Semen Hoveniae (Fructus Hoveniae) 7
Part, 5 parts of purslane, 9 parts of fresh Rhizoma Phragmitis, 7 parts of evodia rutaecarpa, 6 parts of the bark of official magnolia, 7 parts of eclipta, 7 parts of cattail pollen, 7 parts of puncture vine, 5 parts of cymose buckwheat rhizome,
2 parts of Herba Saussureae Involueratae, 9 parts of radix bardanae.
3. the Chinese medicine composition as any one of claim 1-2, it is characterised in that its active component is to use water extraction
Or 40-80% the alcohol reflux of concentration expressed in percentage by volume extract and be prepared from.
4. Chinese medicine composition as claimed in claim 3, it is characterised in that its active component be prepared by the following method and
Into：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time
For 1-3 hours, merge extract solution, filter, relative density is 1.10-1.25 clear cream when filtrate is concentrated into 70-80 DEG C, is produced
Active component.
5. Chinese medicine composition as claimed in claim 3, it is characterised in that its active component be prepared by the following method and
Into：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time
For 1-3 hours, merge extract solution, filter, relative density is 1.05-1.20 clear cream when filtrate is concentrated into 70-80 DEG C, is added
Ethanol, it is 40-70% to make alcohol content, stands 12-24 hours, filtration, and relative density is 1.10- when filtrate is concentrated into 70-80 DEG C
1.25 medicinal extract, produces active component.
6. Chinese medicine composition as claimed in claim 3, it is characterised in that its active component be prepared by the following method and
Into：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is 4-10 times of medicinal material total amount, is carried
It is 1-4 hours to take the time, merges extract solution, is filtered, and relative density is 1.10-1.25 medicinal extract when filtrate is concentrated into 60-80 DEG C,
Produce active component.
7. a kind of antipruritic external medicine composition, including the antipruritic external medicine composition of any one of claim 1~2 with
Pharmaceutically acceptable carrier.
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| CN1065489A (en) * | 1992-01-06 | 1992-10-21 | 张戈平 | The prescription of strengthening wine and preparation technology |
| CN1136929A (en) * | 1995-05-31 | 1996-12-04 | 王超 | Antipruritic skin care preparation |
| CN1927315A (en) * | 2006-09-18 | 2007-03-14 | 杨玉海 | Medicine for treating psoriasis mainly and its preparation method and use |
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2014
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| CN1065489A (en) * | 1992-01-06 | 1992-10-21 | 张戈平 | The prescription of strengthening wine and preparation technology |
| CN1136929A (en) * | 1995-05-31 | 1996-12-04 | 王超 | Antipruritic skin care preparation |
| CN1927315A (en) * | 2006-09-18 | 2007-03-14 | 杨玉海 | Medicine for treating psoriasis mainly and its preparation method and use |
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