CN1927315A - Medicine for treating psoriasis mainly and its preparation method and use - Google Patents
Medicine for treating psoriasis mainly and its preparation method and use Download PDFInfo
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- CN1927315A CN1927315A CN 200610152182 CN200610152182A CN1927315A CN 1927315 A CN1927315 A CN 1927315A CN 200610152182 CN200610152182 CN 200610152182 CN 200610152182 A CN200610152182 A CN 200610152182A CN 1927315 A CN1927315 A CN 1927315A
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Abstract
The invention relates to a medicament for treating psoriasis, process for preparation and use thereof, wherein the raw materials include dried rehmannia root, alkanna tinctoria, dandelion, herba patriniae, pawpaw, cattail pollen, Schizonepeta tenuifolia, root bark of chinese wolf berry, cicada shell, Chinese dittany bark, arctium fruit, puncturevine and licorice root.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof and application, relate in particular to a kind of medicine and preparation method thereof and application for the treatment of psoriasis.
Background technology
Psoriasis is the common multiple dermatosis of modern.The medicine that China treats this disease at present is a lot, as: medicines such as enlightening silver strip, acitretin capsule, bimolane, second imido, FUFANG QINGDAI WAN.
Because the psoriasis course of disease is long, be difficult to cure, so need take Drug therapy for a long time, but medicine can cause that lesions of liver and kidney, gastrointestinal reaction and hematopoietic function are impaired after taking for a long time, cause other diseases and cause new slight illness to the patient.
Good and the psoriatic medicine of treatment that toxic and side effects is little of exploitation therapeutic effect is pressing for of present extensive patients.
Summary of the invention
The object of the present invention is to provide a kind of to dermatosiss such as psoriasis have significant curative effect and take for a long time to human internal organ and function do not occur damaging, novel drugs without any side effects.
Another object of the present invention provides the preparation method of this therapeutic agent.
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components is for all to have curative effect preferably in the following weight parts scope:
Radix Rehmanniae 50-300 Radix Arnebiae (Radix Lithospermi) 15-100 Herba Taraxaci 30-200 Herba Patriniae 50-200
Fructus Chaenomelis 10-100 Pollen Typhae 6-60 Herba Schizonepetae 10-100 Cortex Lycii 30-200
Periostracum Cicadae 3-50 Cortex Dictamni 30-150 Fructus Arctii 10-100 Fructus Tribuli 15-100
Radix Glycyrrhizae 10-100
Weight (part) ratio range of the formula optimization of preparation medicine of the present invention is:
Radix Rehmanniae 230-270 Radix Arnebiae (Radix Lithospermi) 65-85 Herba Taraxaci 130-170 Herba Patriniae 130-170
Fructus Chaenomelis 30-60 Pollen Typhae 15-40 Herba Schizonepetae 30-70 Cortex Lycii 130-170
Periostracum Cicadae 10-20 Cortex Dictamni 80-120 Fructus Arctii 30-70 Fructus Tribuli 65-90
Radix Glycyrrhizae 30-70
Optimum weight (part) proportioning of preparation medicine of the present invention is:
Radix Rehmanniae 250 Radix Arnebiae (Radix Lithospermi)s 75 Herba Taraxacis 150 Herba Patriniae 150 Fructus Chaenomeliss 50
Pollen Typhae 30 Herba Schizonepetae 50 Cortex Lycii 150 Periostracum Cicadaes 15 Cortex Dictamni 100
Fructus Arctii 50 Fructus Tribulis 75 Radix Glycyrrhizaes 50
Above-mentioned prescription of the present invention and medically acceptable adjuvant can be prepared into the dosage form on any pharmaceuticss such as capsule, granule, powder, pill or oral liquid.
Preferably, the preparation method of medicament active composition of the present invention comprises the steps:
(1) Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Herba Patriniae, Fructus Chaenomelis, Pollen Typhae, Herba Schizonepetae, Cortex Lycii, Periostracum Cicadae, Cortex Dictamni, Fructus Arctii, Fructus Tribuli and Radix Glycyrrhizae 13 flavor medicines are standby after choosing medicine, washing, oven dry; (2) take by weighing above-mentioned 13 flavor medicines by required weight proportion, put in the extractor, add water, decoct 2-3 time, each amount of water was not advisable to have powder; (3) collecting decoction, filtration are condensed into the clear paste that relative density is 1.00-1.15; (4) treat that above-mentioned clear paste is chilled to room temperature after, add 1-2 doubly 95% ethanol carry out precipitate with ethanol; (5) get upper strata filtrate, reclaim ethanol and be condensed into the thick paste that relative density is 1.30-1.33; (6) get above-mentioned thick paste, add medically acceptable adjuvant, make various dosage forms.
In the above-mentioned preparation method, the preferred version of each step is: (1) is standby after choosing medicine, washing, oven dry with Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Herba Patriniae, Fructus Chaenomelis, Pollen Typhae, Herba Schizonepetae, Cortex Lycii, Periostracum Cicadae, Cortex Dictamni, Fructus Arctii, Fructus Tribuli and Radix Glycyrrhizae 13 flavor medicines; (2) take by weighing above-mentioned 13 flavor medicines by required weight proportion, put in the extractor, decoct with water 2 times, decoct for the first time institute's amount of water and be 8 times of raw material weight, soaked 1 hour, decocted 1 hour; Decocting for the second time is to add 6 times of amounts of water, soaks 1 hour, decocts 1 hour; (3) collecting decoction, filtration are concentrated into relative density and are 1.07 clear paste under 70-80 ℃; (4) treat that above-mentioned clear paste is chilled to room temperature after, add 95% ethanol and make that to contain alcohol amount be 65%, leave standstill and carried out precipitate with ethanol in 24 hours; (5) take out upper strata filtrate, and with the precipitate of precipitate with ethanol gained 50%-60% ethanol thorough washing, the above-mentioned filtrate of cleaning mixture and precipitate with ethanol gained merges; Reclaim ethanol and be condensed into the thick paste that relative density is 1.30-1.33; (6) get above-mentioned thick paste, add medically acceptable adjuvant, make various dosage forms.
The active component of medicine of the present invention can add various adjuvants required when preparing different dosage form, be prepared into any dosage form as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as capsule, granule, powder, pill or oral liquid etc.
In the preparation method of the present invention, with the thick paste that makes, add cane sugar powder, dextrin system soft material in the preferred steps (6), oven dry adds an amount of wetting agent after pulverizing, and granulates drying.More preferably: get 1 part of the clear paste that makes, 1.8 parts of cane sugar powders, 2.1 parts of systems of dextrin soft material, oven dry adds ethanol after pulverizing, and crosses 14 mesh sieves and granulates 65 ℃ of oven dry; Granulate sieves, packing.
Medicament selection Radix Rehmanniae of the present invention, Radix Arnebiae (Radix Lithospermi) clearing away heat and cooling blood; With Cortex Lycii, Cortex Dictamni, Herba Taraxaci, the blood stasis dispelling of Herba Patriniae clearing away heat-damp and expelling toxic material; Fructus Chaenomelis grows greasy fraud with the system Radix Rehmanniae, removing dampness and stomach function regulating; And with Herba Schizonepetae, Periostracum Cicadae, Fructus Arctii, Fructus Atriplicis Sibiricae dispelling wind for relieving itching, the through sick institute of priming; Be in harmonious proportion the property of medicine with Radix Glycyrrhizae.With these drug regimens, make each efficacy of drugs produce synergism, all medicines cooperate the effect of playing removing pathogenic heat from blood and toxic substance from the body dampness dispelling wind for relieving itching altogether, thereby can effectively treat dermatosis.This side is mainly used in the treatment psoriasis, according to the theory of theory of Chinese medical science treating the same disease with different methods, treating different diseases with the same therapeutic principle, can be used for treating eczema, dermatitis, viral dermatosis etc. equally.
The present invention uses for many years, the tens thousand of examples of treatment patient, clinical its unrivaled superiority that proved.Medication effect of the present invention is good, do not recur, taking convenience, human body is had no side effect.The present invention is mainly used in the treatment psoriasis, also can be used for treating the identical eczema of pathogenesis, dermatitis, viral dermatosis etc. according to the theory of theory of Chinese medical science treating the same disease with different methods, treating different diseases with the same therapeutic principle.
The specific embodiment
The test example:
Data and method:
1, case history inclusion criteria: 1. agree to enter the clinical diagnosis case history through me, 2. 3. not system applies glucocorticoid, immunosuppressant and immunomodulator in all patients 1 month do not have hypertension, aldosterone disease, hypokalemia, myopathy and other serious organ and systemic disease.
2, ordinary circumstance: 76 examples are organized in treatment, male 46 examples, women 30 examples, 12～69 years old age, average (35.63 ± 17.76) year, the shortest 10d of the course of disease, the longest 21 years, wherein drip shape 16 examples, speckle shape 18 examples are mixed shape 32 examples, Folium Styracis Suberifoliae characteristic of disease 10 examples.Matched group 60 examples, male 36 examples, women 24 examples, 12～66 years old age, average (36.23 ± 17.86) year, the shortest 15d of the course of disease, the longest 19 years, wherein drip shape 12 examples, speckle shape 16 examples are mixed shape 24 examples, Folium Styracis Suberifoliae characteristic of disease 8 examples.
3, Therapeutic Method: the treatment group adopts granule of the present invention oral, every day 2 times, each 18g; It is oral that matched group is taken FUFANG QINGDAI WAN, every day 3 times, each 6g; Take medicine continuously and 8 weeks carried out therapeutic evaluation.1～3 month course of treatment, follow up a case by regular visits to half a year.
4, criterion: the scope and the order of severity according to patient's erythema, infiltration, squama before and after treatment are carried out the PASI scoring, and calculate the variation percentage rate for the treatment of front and back PASI, computational methods are as follows: PASI changes percentage rate=(total points after total points before the treatment-treatment)/total points * 100% before treating.Percentage rate＞95% be base more, 61%～95% be produce effects, 31%～60% be that effectively percentage rate≤30% is invalid, case load * 100% of total effective rate=(base heal the routine number of routine number+produce effects)/always.Detect blood pressure and blood potassium level during the treatment, take place serious adverse reaction withdraw from the observer be judged to invalid.Base is healed and the produce effects case is followed up a case by regular visits to half a year, and the PASI scoring does not have the person of increasing and is judged to the nothing recurrence.
5, statistical procedures:, two groups of total effective routine numbers of treatment are carried out x to PASI scoring before and after every group of treatment and two kinds of method treatment back PASI scoring carrying out respectively t check
2Check.
The result:
Treatment organize in 76 examples base more 28 examples account for 36.8%, produce effects 30 examples account for 39.5%, effective 6 examples, invalid 12 examples, total effective rate 76.3%.Basic more 4 examples account for 6.7% in matched group 60 examples, and produce effects 28 examples account for 46.7%, effective 4 examples, and invalid 16 examples, 53.3%, two group of total effective rate difference of total effective rate has statistical significance (x
2=3.95, p＜0.05).The PASI diversity of values all has statistical significance, (t=2.10, p＜0.05) before and after two groups of treatments.See the following form.
() compared in the PASI scoring before and after two groups of treatment psoriasises
| Group | The example number | Before the treatment | After the treatment | The t value | The p value |
| Treatment group matched group | 76 60 | 11.13±4.70 11.28±4.70 | 2.61±3.31 4.62±4.34 | 11.59 9.13 | ＜0.001 ＜0.001 |
Do not have and to withdraw from case, follow up a case by regular visits to half a year after, the treatment group does not have recurrent cases, matched group recurs 2 examples.
Untoward reaction: treatment is organized none routine untoward reaction and is taken place.Chronic abdominal pain 20 examples appear in matched group, 15 examples of suffering from diarrhoea, and constipation 5 examples, liver enzyme 3 examples that raise behind the symptomatic treatment, make 43 routine patients finish the overall process of treatment.
The preparation of embodiment 1 medicinal granule of the present invention:
Prescription: Radix Rehmanniae 250g Radix Arnebiae (Radix Lithospermi) 75g Herba Taraxaci 150g Herba Patriniae 150g Fructus Chaenomelis 50g Pollen Typhae 30g Herba Schizonepetae 50g Cortex Lycii 150g Periostracum Cicadae 15g Cortex Dictamni 100g Fructus Arctii 50g Fructus Tribuli 75g Radix Glycyrrhizae 50g
Method for making: 13 flavor medicine weighings after choosing medicine, washing, oven dry in the general side.Put and add 8 times of water gagings in the extractor, soaked 1 hour, decoct 2 times (adding 6 times of water gagings for the second time), each 1 hour, collecting decoction, filtration.Be concentrated into relative density and be about 1.07 (70-80 ℃), room temperature to be chilled to, adding 95% ethanol, to make the alcohol amount of containing be 65% to leave standstill 24 hours. get supernatant and reclaim ethanol, being concentrated into relative density is the thick paste of 1.30-1.33 (80 ℃).Get 1 part of thick paste, 1.8 parts of cane sugar powders, 2.1 parts of systems of dextrin soft material, oven dry is pulverized and is added 65 ℃ of oven dry of an amount of mistake 14 mesh sieves granulation of ethanol, makes 1000g.Granulate sieves, and packing promptly.
Embodiment 2-7
Preparation method is with embodiment 1.
The prescription of each embodiment sees the following form: (its unit of weight is gram)
| Material name | Radix Rehmanniae | Radix Arnebiae (Radix Lithospermi) | Herba Taraxaci | Herba Patriniae | Fructus Chaenomelis | Pollen Typhae | Herba Schizonepetae | Cortex Lycii | Periostracum Cicadae | Cortex Dictamni | Fructus Arctii | Fructus Tribuli | Radix Glycyrrhizae |
| Example 1 | 250 | 75 | 150 | 150 | 50 | 30 | 50 | 150 | 15 | 100 | 50 | 75 | 50 |
| Example 2 | 200 | 60 | 125 | 125 | 40 | 25 | 40 | 125 | 12 | 85 | 40 | 60 | 40 |
| Example 3 | 175 | 55 | 110 | 110 | 35 | 18 | 35 | 110 | 10 | 80 | 35 | 55 | 35 |
| Example 4 | 150 | 40 | 90 | 90 | 30 | 13 | 30 | 90 | 8 | 70 | 30 | 40 | 30 |
| Example 5 | 100 | 30 | 70 | 70 | 24 | 10 | 24 | 70 | 6 | 55 | 24 | 30 | 24 |
| Example 6 | 75 | 25 | 50 | 50 | 18 | 8 | 18 | 50 | 5 | 40 | 18 | 25 | 18 |
| Example 7 | 50 | 15 | 30 | 30 | 10 | 6 | 10 | 30 | 3 | 30 | 10 | 15 | 10 |
Other embodiment:
Adopt the prescription among the foregoing description 1-7 successively, prepare capsule, powder, pill and oral liquid formulation with the method for Chinese medicinal of routine.
Different dosage form and instructions of taking:
A 18g is oral for granule one twice-daily
Three times one time on the one 0.5g * 8 of tablet are slice oral
A 9g * 1 ball is oral for pill one twice-daily
A 100ml is oral for decoction one twice-daily
Three times one time on the one 0.25g * 6 of capsule are oral
A 20ml is oral for oral liquid one twice-daily
Obviously, the above embodiment of the present invention only is for example of the present invention clearly is described, and is not to be qualification to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here need not also can't give exhaustive to all embodiments.And these belong to conspicuous variation or the change that spirit of the present invention extended out and still are among protection scope of the present invention.
Claims (10)
1. the medicine of a treating psoriasis is characterized in that it mainly is to be made by the following weight proportion raw material: Radix Rehmanniae 50-300, Radix Arnebiae (Radix Lithospermi) 15-100, Herba Taraxaci 30-200, Herba Patriniae 50-200, Fructus Chaenomelis 10-100, Pollen Typhae 6-60, Herba Schizonepetae 10-100, Cortex Lycii 30-200, Periostracum Cicadae 3-50, Cortex Dictamni 30-150, Fructus Arctii 10-100, Fructus Tribuli 15-100, Radix Glycyrrhizae 10-100.
2. medicine according to claim 1, wherein the weight proportion of each raw material is: Radix Rehmanniae 230-270, Radix Arnebiae (Radix Lithospermi) 65-85, Herba Taraxaci 130-170, Herba Patriniae 130-170, Fructus Chaenomelis 30-60, Pollen Typhae 15-40, Herba Schizonepetae 30-70, Cortex Lycii 130-170, Periostracum Cicadae 10-20, Cortex Dictamni 80-120, Fructus Arctii 30-70, Fructus Tribuli 65-90, Radix Glycyrrhizae 30-70.
3. medicine according to claim 1, wherein the weight proportion of each raw material is: Radix Rehmanniae 250, Radix Arnebiae (Radix Lithospermi) 75, Herba Taraxaci 150, Herba Patriniae 150, Fructus Chaenomelis 50, Pollen Typhae 30, Herba Schizonepetae 50, Cortex Lycii 150, Periostracum Cicadae 15, Cortex Dictamni 100, Fructus Arctii 50, Fructus Tribuli 75, Radix Glycyrrhizae 50.
4. according to claim 1,2 or 3 described medicines, it is characterized in that it being to form dosage form on any pharmaceutics with medically acceptable adjuvant.
5. medicine according to claim 4 is characterized in that it being to form capsule, granule, powder, pill or oral liquid with medically acceptable adjuvant.
6. the preparation method of medicine according to claim 4, it comprises the following steps: that (1) is standby after choosing medicine, washing, oven dry with Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Herba Patriniae, Fructus Chaenomelis, Pollen Typhae, Herba Schizonepetae, Cortex Lycii, Periostracum Cicadae, Cortex Dictamni, Fructus Arctii, Fructus Tribuli and Radix Glycyrrhizae 13 flavor medicines; (2) take by weighing above-mentioned 13 flavor medicines by required weight proportion, put in the extractor, add water, decoct 2-3 time, each amount of water was not advisable to have powder; (3) collecting decoction, filtration are condensed into the clear paste that relative density is 1.00-1.15; (4) treat that above-mentioned clear paste is chilled to room temperature after, add 1-2 doubly 95% ethanol carry out precipitate with ethanol; (5) get upper strata filtrate, reclaim ethanol and be condensed into the thick paste that relative density is 1.30-1.33; (6) get above-mentioned thick paste, add medically acceptable adjuvant, make various dosage forms.
7. the preparation method of medicine according to claim 6 is wherein in step (2): decoct with water twice; Decoct for the first time institute's amount of water and be 8 times of raw material weight, soaked 1 hour, decocted 1 hour; Decocting for the second time is to add 6 times of amounts of water, soaks 1 hour, decocts 1 hour; In the step (3): be that to be concentrated into relative density under 70-80 ℃ be 1.07 clear paste; In the step (4): add ethanol and make that to contain the alcohol amount be 65%, leave standstill and carried out precipitate with ethanol in 24 hours; In the step (5): with the precipitate of precipitate with ethanol gained 50%-60% ethanol thorough washing, the filtrate of cleaning mixture and precipitate with ethanol gained merges; Decompression filtrate recycling ethanol with after merging is condensed into thick paste.
8. the preparation method of medicine according to claim 7, step wherein (6) is: get the thick paste that makes, add cane sugar powder, dextrin system soft material, oven dry adds an amount of wetting agent after pulverizing, granulation, drying.
9. the preparation method of medicine according to claim 8, wherein in step (1): the consumptions of 13 flavor medicines are: Radix Rehmanniae 250 grams, Radix Arnebiae (Radix Lithospermi) 75 grams, Herba Taraxaci 150 grams, Herba Patriniae 150 grams, Fructus Chaenomelis 50 grams, Pollen Typhae 30 grams, Herba Schizonepetae 50 grams, Cortex Lycii 150 grams, Periostracum Cicadae 15 grams, Cortex Dictamni 100 grams, Fructus Arctii 50 grams, Fructus Tribuli 75 grams, Radix Glycyrrhizae 50 grams; In the step (6): get 1 part of the clear paste that makes, 1.8 parts of cane sugar powders, 2.1 parts of systems of dextrin soft material, oven dry adds ethanol after pulverizing, and crosses 14 mesh sieves and granulates 65 ℃ of oven dry; Granulate sieves, packing.
10. according to claim 1, the application of 2 or 3 described medicines in the medicine of preparation treatment psoriasis, eczema, dermatitis, viral dermatosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610152182XA CN100381144C (en) | 2006-09-18 | 2006-09-18 | Medicine for treating psoriasis mainly and its preparation method and use |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200610152182XA CN100381144C (en) | 2006-09-18 | 2006-09-18 | Medicine for treating psoriasis mainly and its preparation method and use |
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| CN1927315A true CN1927315A (en) | 2007-03-14 |
| CN100381144C CN100381144C (en) | 2008-04-16 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068639A (en) * | 2011-01-10 | 2011-05-25 | 王宝香 | Externally traditional Chinese medicine for treating pustulosis |
| CN103239655A (en) * | 2013-05-08 | 2013-08-14 | 徐金法 | Macule-transforming decoction for treating psoriasis |
| CN104147481A (en) * | 2014-07-17 | 2014-11-19 | 覃业宇 | Externally used traditional Chinese medicine (TCM) composition for relieving itching and preparation method thereof |
| CN104491084A (en) * | 2014-12-04 | 2015-04-08 | 翟永华 | Traditional Chinese medicine for treating dermatitis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129577A (en) * | 1995-09-15 | 1996-08-28 | 贾阳春 | Pellets for curing tinea |
| CN1056531C (en) * | 1997-08-29 | 2000-09-20 | 刘进成 | Chinese medicinal herb composition for treating skin disease |
-
2006
- 2006-09-18 CN CNB200610152182XA patent/CN100381144C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068639A (en) * | 2011-01-10 | 2011-05-25 | 王宝香 | Externally traditional Chinese medicine for treating pustulosis |
| CN103239655A (en) * | 2013-05-08 | 2013-08-14 | 徐金法 | Macule-transforming decoction for treating psoriasis |
| CN103239655B (en) * | 2013-05-08 | 2014-07-16 | 徐金法 | Macule-transforming decoction for treating psoriasis |
| CN104147481A (en) * | 2014-07-17 | 2014-11-19 | 覃业宇 | Externally used traditional Chinese medicine (TCM) composition for relieving itching and preparation method thereof |
| CN104147481B (en) * | 2014-07-17 | 2017-10-20 | 覃业宇 | A kind of antipruritic external medicine composition and preparation method thereof |
| CN104491084A (en) * | 2014-12-04 | 2015-04-08 | 翟永华 | Traditional Chinese medicine for treating dermatitis |
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| Publication number | Publication date |
|---|---|
| CN100381144C (en) | 2008-04-16 |
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