CN104800331A - Traditional Chinese medicine oral liquid for treating varicosity of lower limbs - Google Patents

Abstract

The invention discloses a traditional Chinese medicine oral liquid for treating varicosity of lower limbs. The traditional Chinese medicine oral liquid is prepared from traditional Chinese medicine raw materials in parts by weight as follows: 100-600 parts of Chinese thorowax root, 80-300 parts of India madder root, 80-300 parts of angelica dahurica, 100-300 parts of red paeony root, 100-300 parts of sappan wood, 80-300 parts of flos carthami, 80-300 parts of officinal magnolia bark, 10-50 parts of towel gourd vegetable sponge, 80-300 parts of akebia stem and 80-300 parts of radix ranunculi ternati. The traditional Chinese medicine oral liquid for treating varicosity of lower limbs has a high curative effect, does not have toxic or side effects, is applicable to varicosity of the lower limbs and used for treating mild, medium and severe varicosity of the lower limb on a single side or the lower limbs on two sides, has advantages of remarkable curative effect, low relapse rate, no adverse reaction and the like and has vast economic and social benefits and remarkable clinical popularization value.

Description

A kind of Chinese medicine oral liquid for the treatment of varicose veins of the lower extremity or fried muscle lower limb

Technical field

The present invention relates to varicose veins of the lower extremity or fried muscle lower limb field, be used for one-sided, bilateral for treatment limb varicosis, light, in, severe varicose veins of the lower extremity, especially provide a kind of Chinese medicine oral liquid for the treatment of varicose veins of the lower extremity or fried muscle lower limb.

Background technology

Fried muscle lower limb (varicose veins of the lower extremity) call mainly in the traditional Chinese medical science, fried muscle lower limb main feature is blood vessel enhancement skin surface, as Lumbricus, having many bends or curves, rough.Now along with the many colonies of job specification: the professional Jie Shi highrisk populations that teacher, surgeon, nurse, stylist, special counter Miss, cook, table steward etc. need stand for a long time.In addition varicosis and heredity, oral contraceptive and pregnancy also have relevant.Because the past is not paid attention to varicosis, the research of this respect is also fewer, just in the last few years abroad the disease of this for varicosis phenomenon standard setting " chronic venous insufficiency ".But no matter be in pharmacy or in hospital, there is no the clear and definite labeled for treatment of a kind of medicine " varicosis ".Thus, people generally believe " varicosis medicine is difficult to play a role, and only has last resort to perform the operation ".But we still can treat and prevent cirsoid expanded range and alleviate its symptom by mat drug matching oral liquid.Simultaneously patient should be noted that in the later stage and is: walk, motion that swimming, bicycle etc. comparatively relax, and decapacitation improves outside circulation, can also reduce the speed of new varicosis generation.In diet, high fine, low fat diet should be eaten more and strengthen vitamin C, the supplementing of E.In daily life, then should control body weight, avoid taking contraceptive, avoid the medicated clothing of wear tension and high-heel shoes, lift up cross-legged and avoid sitting or stand for a long time.Before sleeping every day, lower limb is raised a period of time, the left side can be slept to reduce the venacaval pressure of pelvis in side in bed.Smoking can make blood pressure raise and artery and vein impaired, cirsoid patient should give up smoking immediately.The demand of clinical patients, Chinese medicine oral liquid treatment varicose veins of the lower extremity described in the property of the present invention is directed to utilizes is to meet clinical patients, few, this just needs the Chinese medicine oral liquid of a immunotherapy targeted autoantibody varicose veins of the lower extremity or fried muscle lower limb to embody clinical generalization value.

Summary of the invention

The object of the invention is for treatment limb varicosis for one-sided, bilateral, gently, in, the patient with sympotoms such as severe varicose veins of the lower extremity, the problem that a kind of Chinese medicine oral liquid for the treatment of varicose veins of the lower extremity or fried muscle lower limb proposes to meet above-mentioned background technology is especially provided.

To achieve these goals, the invention provides following technical scheme:

A kind of Chinese medicine oral liquid for the treatment of varicose veins of the lower extremity or fried muscle lower limb of the present invention, it is mixed with by the raw material of Chinese medicine of following weight parts proportioning: Radix Bupleuri 100 ~ 600 parts, 80 ~ 300 parts, Radix Rubiae, the Radix Angelicae Dahuricae 80 ~ 300 parts, Radix Paeoniae Rubra 100 ~ 300 parts, Lignum Sappan 100 ~ 300 parts, 80 ~ 300 parts, Flos Carthami, Cortex Magnoliae Officinalis 80 ~ 300 parts, Retinervus Luffae Fructus 10 ~ 50 parts, Caulis Akebiae 80 ~ 300 parts, Radix Ranunculi Ternati 80 ~ 300 parts.

A kind of Chinese medicine oral liquid for the treatment of varicose veins of the lower extremity or fried muscle lower limb of the present invention, preferred is mixed with by the raw material of Chinese medicine of following weight parts proportioning: Radix Bupleuri 300 ~ 500 parts, 180 ~ 300 parts, Radix Rubiae, the Radix Angelicae Dahuricae 180 ~ 300 parts, Radix Paeoniae Rubra 200 ~ 300 parts, Lignum Sappan 200 ~ 300 parts, 180 ~ 300 parts, Flos Carthami, Cortex Magnoliae Officinalis 200 ~ 300 parts, Retinervus Luffae Fructus 30 ~ 50 parts, Caulis Akebiae 200 ~ 300 parts, Radix Ranunculi Ternati 200 ~ 300 parts.

A kind of Chinese medicine oral liquid for the treatment of varicose veins of the lower extremity or fried muscle lower limb of the present invention, best preferred to be mixed with by the raw material of Chinese medicine of following weight parts proportioning: Radix Bupleuri 500 parts, 250 parts, Radix Rubiae, the Radix Angelicae Dahuricae 250 parts, Radix Paeoniae Rubra 250 parts, Lignum Sappan 250 parts, 250 parts, Flos Carthami, Cortex Magnoliae Officinalis 250 parts, Retinervus Luffae Fructus 30 parts, Caulis Akebiae 250 parts, Radix Ranunculi Ternati 250 parts.

Medical material used in the present invention has following characteristic:

Radix Bupleuri: Radix Bupleuri, Chinese medicine name.For the medical herbs that " Chinese Pharmacopoeia " includes, medicinal part is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Another name ground smoke, mountain dish, mushroom grass, faggot, [nature and flavor] hardship, be slightly cold.[return through] returns liver, gallbladder meridian.[function cures mainly] reconciling superficies and interior, soothing the liver, yang invigorating.

Radix Rubiae: [another name] Galium spurium L., uproot plants after their edible portions have been harvested, HUOXUECAO, red Radix Rubiae, carriage, extension draw bean, red line grass, Radix seu Caulis Schisandrae Sinensis, Herba Chenopodii Hybridi, [source] this product is the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..[nature and flavor] are bitter, cold.[return through] returns Liver Channel.[function cures mainly] removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.

The Radix Angelicae Dahuricae: [source] this product is the dry root of umbellate form section plant Radix Angelicae Dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f. or Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan.[nature and flavor] are pungent, temperature.[return through] returns stomach, large intestine, lung meridian.[function cures mainly] loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.

Radix Paeoniae Rubra: [another name] mountain Radix Paeoniae, Paeonia obovata Maxim., [source] this product is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactifloraPall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.[nature and flavor] are bitter, are slightly cold.[return through] returns Liver Channel.[function cures mainly] clearing away heat and cooling blood, eliminating stasis to stop pain.

Lignum Sappan: [source] this product is the dry duramen of pulse family Caesalpinia Lignum Sappan Caesalpinia sappan L..[nature and flavor] are sweet, salty, flat.[return through] GUIXIN, liver, spleen channel.[function cures mainly] promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.

Flos Carthami: [another name] Flos Carthami, [source] this product is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..[character] this product is the tubular flower not with ovary, long 1 ~ 2cm.Surface red is yellow or red.[nature and flavor] are pungent, temperature.[return through] GUIXIN, Liver Channel.[function cures mainly] promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.[extracts] " Chinese Pharmacopoeia ".

Cortex Magnoliae Officinalis: [another name] Cortex Magnoliae Officinalis, CORTEX MAGNOLIAE OFFICINALIS, [source] this product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis Magnolia officinalisRehd.et Wils. or magnolia officinalis rehd.et wils.var.biloba rehd.et wils. Magnolia officinalis Rehd.et Wils.var.biloba Rehd.et Wils., root bark and branch skin.[nature and flavor] are bitter, pungent, temperature.[return through] returns spleen, stomach, lung, large intestine channel.The expectorant of [function cures mainly] dampness, the therapeutic method to keep the adverse QI flowing downwards is except full.

Retinervus Luffae Fructus: [source] this product is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..[nature and flavor] are sweet, flat.[return through] returns lung, stomach, Liver Channel.[function cures mainly] dredging collateral, invigorates blood circulation, dispels the wind.

Caulis Akebiae: [another name] Medulla Tetrapanacis, attached (" herbal classic "), fourth father-in-law (" WU Pu Bencao "), Caulis et Folium piperis (" extensively refined "), Weed rattan (Collective Notes to the Canon of Materia medica), king father-in-law, Wan Nian, 10000 years rattans (" property of medicine opinion "), swallow Fu, black Fu (Tang Materia Medica).[source] is plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, the woody stems of Caulis Akebiae.[nature and flavor] are bitter, cool.[return through] enters the heart, small intestinal, urinary bladder channel.[function cures mainly] pathogenic fire purging row water, promoting blood circulation.

Radix Ranunculi Ternati: [source] this product is the dried root of ranunculaceae plant Seynuns Kugelann Ranunculus ternatus Thunb..[character] this product is spindle, and many 5 ~ 6 cluster, likeness in form ram's horn, and long 3 ~ 10mm, diameter 2 ~ 3mm, there are the residual stem of yellowish-brown or stem trace in top.Surface yellowish-brown or lark, color and luster stored for a long time deepens, and micro-have vertical wrinkle, and has point-like mark of fibrous root and residual fibrous root.Matter is solid, section off-white color or yellow-white, hollow or solid, mealiness.Feeble QI, taste is micro-sweet.[nature and flavor] sweet, acrid, warm.[return through] returns liver, lung meridian.[function cures mainly] eliminating stagnation, detumescence.

The present invention also provides the preparation method of above-mentioned Chinese medicine oral liquid, and the method usually adopting people to know in the art comprises the steps:

1) following weight parts proportioning raw material of Chinese medicine is taken: Radix Bupleuri 100 ~ 600 parts, 80 ~ 300 parts, Radix Rubiae, the Radix Angelicae Dahuricae 80 ~ 300 parts, Radix Paeoniae Rubra 100 ~ 300 parts, Lignum Sappan 100 ~ 300 parts, 80 ~ 300 parts, Flos Carthami, Cortex Magnoliae Officinalis 80 ~ 300 parts, Retinervus Luffae Fructus 10 ~ 50 parts, Caulis Akebiae 80 ~ 300 parts, Radix Ranunculi Ternati 80 ~ 300 parts;

2) above-mentioned raw material of Chinese medicine soak by water secondary, each water consumption is the 8-10 times amount of medical material weight, decocts secondary, each 1-2 hour, filters, and filtrate is condensed into and surveys relative density at 60-65 DEG C is the clear paste of 1.10-1.25;

3) by step 2) to add ethanol to making containing amount of alcohol be 60% for the clear paste that obtains, stir evenly, leave standstill, filter, get filtrate recycling ethanol, be condensed into the extractum containing solid weight 65-67%;

4) by step 3) extractum that obtains adds sucrose 20%, refined honey 12%, antiseptic 1-3%, stock solution embedding, irradiation sterilization, and packed products, makes oral liquid, to obtain final product.

Using method: every day is early, middle and late respectively takes once, and a dose is 15ml, 20 days 1 courses for the treatment of, manyly after taking medicine took effect at 7 days, 1-3 the healing course for the treatment of.(remarks: while oral, this Chinese medicine oral liquid also can be used to become soaked with sweat and wash varicose position 10 ~ 15 minutes, therapeutic effect is better.)

Beneficial effect

The present invention has selected Chinese crude drug as the Chinese medicine oral liquid for the treatment of varicose veins of the lower extremity or fried muscle lower limb, start with from strengthening the body resistance, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic simultaneously, comprehensive determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, thus elimination paathogenic factor, the function of each system of comprehensive adjustment human body, strengthen human body stress and tolerance, therefore therapeutic effect is good.Namely varicose veins of the lower extremity or fried muscle lower limb most patients take has positive effect 20 days (1 course for the treatment of), and veins of lower extremity tortuous attenuates, venous congestion edema goes down, the cutaneous pigmentation of local, and fester, the symptom phenomenons such as ulcer are obviously improved; Continue to take 1-3 the course for the treatment of, varicose veins of the lower extremity recovers normal gradually, is fully recovered.

The effect of Chinese medicine oral liquid of the present invention is set forth further below by way of clinical observation on the therapeutic effect.

1, physical data

Accept out-patient for medical treatment and have 80 examples altogether, 35 ~ 70 years old age, more than the course of disease 6 ~ December.

2, criterion of therapeutical effect

Formulate with reference to " Chinese medicine Clinical Researches of New Drugs guideline ".

Cure: clinical symptom disappearance, varicose veins of the lower extremity recover normal;

Effective: clinical symptoms obviously alleviates, tortuously the attenuating of veins of lower extremity, venous congestion edema go down;

Take a turn for the better: clinical symptoms cutaneous pigmentation, fester, ulcer partial disappearance;

Invalid: without obviously changing after treatment, or after treatment, symptom and Signs increase the weight of.

3, therapeutic outcome, sees the following form:

Detailed description of the invention

Embodiment 1

Raw material: Radix Bupleuri 500 parts, 250 parts, Radix Rubiae, the Radix Angelicae Dahuricae 250 parts, Radix Paeoniae Rubra 250 parts, Lignum Sappan 250 parts, 250 parts, Flos Carthami, Cortex Magnoliae Officinalis 250 parts, Retinervus Luffae Fructus 30 parts, Caulis Akebiae 250 parts, Radix Ranunculi Ternati 250 parts.

Preparation:

1) following weight parts proportioning raw material of Chinese medicine is taken: Radix Bupleuri 500 parts, 250 parts, Radix Rubiae, the Radix Angelicae Dahuricae 250 parts, Radix Paeoniae Rubra 250 parts, Lignum Sappan 250 parts, 250 parts, Flos Carthami, Cortex Magnoliae Officinalis 250 parts, Retinervus Luffae Fructus 30 parts, Caulis Akebiae 250 parts, Radix Ranunculi Ternati 250 parts;

2) above-mentioned raw material of Chinese medicine soak by water secondary, each water consumption is the 8-10 times amount of medical material weight, decocts secondary, each 1-2 hour, filters, and filtrate is condensed into and surveys relative density at 60-65 DEG C is the clear paste of 1.10-1.25;

3) by step 2) to add ethanol to making containing amount of alcohol be 60% for the clear paste that obtains, stir evenly, leave standstill, filter, get filtrate recycling ethanol, be condensed into the extractum containing solid weight 65-67%;

4) by step 3) extractum that obtains adds sucrose 20%, refined honey 12%, antiseptic 1-3%, stock solution embedding, irradiation sterilization, and packed products, makes oral liquid, to obtain final product.

Using method: every day is early, middle and late respectively takes once, and a dose is 15ml, 20 days 1 courses for the treatment of, manyly after taking medicine took effect at 7 days, 1-3 the healing course for the treatment of.(remarks: while oral, this Chinese medicine oral liquid also can be used to become soaked with sweat and wash varicose position 10 ~ 15 minutes, therapeutic effect is better.)

Embodiment 2

Raw material: Radix Bupleuri 600 parts, 300 parts, Radix Rubiae, the Radix Angelicae Dahuricae 300 parts, Radix Paeoniae Rubra 300 parts, Lignum Sappan 300 parts, 300 parts, Flos Carthami, Cortex Magnoliae Officinalis 300 parts, Retinervus Luffae Fructus 50 parts, Caulis Akebiae 300 parts, Radix Ranunculi Ternati 300 parts.

Preparation and application is with embodiment 1.

Embodiment 3

Raw material: Radix Bupleuri 100 parts, 80 parts, Radix Rubiae, the Radix Angelicae Dahuricae 80 parts, Radix Paeoniae Rubra 100 parts, Lignum Sappan 100 parts, 80 parts, Flos Carthami, Cortex Magnoliae Officinalis 80 parts, Retinervus Luffae Fructus 10 parts, Caulis Akebiae 80 parts, Radix Ranunculi Ternati 80 parts.

Preparation and application is with embodiment 1.

Model case

Case 1 Zhang, Xiangshan of Zhejiang Province people, women, 50 years old, outbreak both legs pain after walking since in August, 2010.Patient's both legs pain repeatedly, shows effect during walking.Without pain after taking a load off one's feet.Seek medical advice invalid over the years.The following varicosis of two ankle joint is obvious, works at an early age and stands for a long time.Two leftover bits and pieces is without atrophy.Receive can, sleep poor, sleep every night about 4 hours, cannot fall asleep after waking up, urine is normal, and nocturia 1-2 time, defecates 1-2 days once, normally, time have uncomfortable in chest, dizziness.Light red tongue tongue is white thick greasy, and arteries and veins is slightly slick and frivolous, and two chi is slightly heavy.Facies cruralis posterior pain.From symptom, varicosis or the disease such as phlebitis and thrombosis, use Chinese medicine oral liquid of the present invention afterwards, after 20 days, both legs pain disappears, the following varicosis of two ankle joint goes down, attenuate, thin out, uncomfortable in chest, dizziness also disappears, and adheres to afterwards taking 2 courses for the treatment of (while oral, also use this Chinese medicine oral liquid to become soaked with sweat and wash varicose position 10 ~ 15 minutes) fully recover at present, recurrence that so far there are no.

Case 2 Yang, Yin state, Ningbo hole bridge people, male, 68 years old, right lower extremity suffered from varicosis more than ten years, because family is in rural area, right leg is swollen and is turned sour, and blue veins is given prominence to, cutaneous pigmentation, fester, ulcer, even the swelling of lower limb and bursting property pain, have sense of heaviness when shank is stood, fatiguability, night must not have a rest.Arrive large hospital inspection afterwards: ultrasonic doppler, peripheral vessels somascope, judged that whether Deep venou was unobstructed, judge Muscular loop function situation.Diagnosis: the situations such as Deep venous valve malfunction, thrombophlebitis, venous ulcer, consider that patient is advanced in age, not too be applicable to having an operation, consider Chinese traditional treatment afterwards, selected Chinese medicine oral liquid of the present invention afterwards, take 1 course for the treatment of (while oral, also using this Chinese medicine oral liquid become soaked with sweat wash varicose, the position 10 ~ 15 minutes of festering), the state of an illness takes an evident turn for the better afterwards, right leg swell turn sour, pain relief; Not sense of heaviness as before when shank is stood, festers, ulcer has controlled, and adhere to use 2 courses for the treatment of afterwards again, current patient cures, and health is fine, has no recurrence.

Claims (4)

1. treat the Chinese medicine oral liquid of varicose veins of the lower extremity or fried muscle lower limb for one kind, it is characterized in that, it is mixed with by the raw material of Chinese medicine of following weight parts proportioning: Radix Bupleuri 100 ~ 600 parts, 80 ~ 300 parts, Radix Rubiae, the Radix Angelicae Dahuricae 80 ~ 300 parts, Radix Paeoniae Rubra 100 ~ 300 parts, Lignum Sappan 100 ~ 300 parts, 80 ~ 300 parts, Flos Carthami, Cortex Magnoliae Officinalis 80 ~ 300 parts, Retinervus Luffae Fructus 10 ~ 50 parts, Caulis Akebiae 80 ~ 300 parts, Radix Ranunculi Ternati 80 ~ 300 parts.

2. Chinese medicine oral liquid according to claim 1, it is characterized in that, it is mixed with by the raw material of Chinese medicine of following weight parts proportioning: Radix Bupleuri 300 ~ 500 parts, 180 ~ 300 parts, Radix Rubiae, the Radix Angelicae Dahuricae 180 ~ 300 parts, Radix Paeoniae Rubra 200 ~ 300 parts, Lignum Sappan 200 ~ 300 parts, 180 ~ 300 parts, Flos Carthami, Cortex Magnoliae Officinalis 200 ~ 300 parts, Retinervus Luffae Fructus 30 ~ 50 parts, Caulis Akebiae 200 ~ 300 parts, Radix Ranunculi Ternati 200 ~ 300 parts.

3. Chinese medicine oral liquid according to claim 1, it is characterized in that, it is mixed with by the raw material of Chinese medicine of following weight parts proportioning: Radix Bupleuri 500 parts, 250 parts, Radix Rubiae, the Radix Angelicae Dahuricae 250 parts, Radix Paeoniae Rubra 250 parts, Lignum Sappan 250 parts, 250 parts, Flos Carthami, Cortex Magnoliae Officinalis 250 parts, Retinervus Luffae Fructus 30 parts, Caulis Akebiae 250 parts, Radix Ranunculi Ternati 250 parts.

4. the preparation method of Chinese medicine oral liquid according to claim 1, is characterized in that, the method comprises the steps:

1) following weight parts proportioning raw material of Chinese medicine is taken: Radix Bupleuri 100 ~ 600 parts, 80 ~ 300 parts, Radix Rubiae, the Radix Angelicae Dahuricae 80 ~ 300 parts, Radix Paeoniae Rubra 100 ~ 300 parts, Lignum Sappan 100 ~ 300 parts, 80 ~ 300 parts, Flos Carthami, Cortex Magnoliae Officinalis 80 ~ 300 parts, Retinervus Luffae Fructus 10 ~ 50 parts, Caulis Akebiae 80 ~ 300 parts, Radix Ranunculi Ternati 80 ~ 300 parts;

2) above-mentioned raw material of Chinese medicine soak by water secondary, each water consumption is the 8-10 times amount of medical material weight, decocts secondary, each 1-2 hour, filters, and filtrate is condensed into and surveys relative density at 60-65 DEG C is the clear paste of 1.10-1.25;

3) by step 2) to add ethanol to making containing amount of alcohol be 60% for the clear paste that obtains, stir evenly, leave standstill, filter, get filtrate recycling ethanol, be condensed into the extractum containing solid weight 65-67%;

4) by step 3) extractum that obtains adds sucrose 20%, refined honey 12%, antiseptic 1-3%, stock solution embedding, irradiation sterilization, and packed products, makes oral liquid, to obtain final product.