CN104042774A

CN104042774A - Medicine composition for treatment of osteoporosis

Info

Publication number: CN104042774A
Application number: CN201410281661.6A
Authority: CN
Inventors: 曾翠芸
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-23
Filing date: 2014-06-23
Publication date: 2014-09-17

Abstract

The invention discloses a medicine composition for the treatment of osteoporosis. The medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of rhizoma drynariae, 10-20 parts of eucommia barks, 10-20 parts of astragalus membranaceus, 6-14 parts of radix dipsaci, 6-14 parts of fructus ligustri lucidi, 6-14 parts of dodder, 6-14 parts of medicinal indianmulberry roots, 4-8 parts of epimedium, 6-14 parts of herb pyrolae, 6-14 parts of cornel, 6-14 parts of fructus lycii and 6-14 parts of cortex periplocae. The medicine composition disclosed by the invention overcomes defects of existing medicine compositions for the treatment of osteoporosis, and the medicine composition has good treatment effect on osteoporosis.

Description

A kind of pharmaceutical composition for the treatment of osteoporosis

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of osteoporosis.

Background technology

Osteoporosis is common complaint among the elderly, and the cause of disease mainly contains endocrine decline, old people is movable few.Main manifestations feature is lower limb back pain, even whole body osteodynia of two hip pain, weak, when serious, can cause fracture because of microtrauma or light activity, and often more difficult healing of senile fracture.The whole world approximately 200,000,000 people suffer from osteoporosis at present, its sickness rate has leapt to commonly encountered diseases, frequently-occurring disease the 7th, World Health Organization (WHO) is by location on annual October 20 " international osteoporosis day ", to get up to arouse attention and the control of the whole world to osteoporosis for this reason.

Medical circle is mainly with chemotherapy osteoporosis, but chemicals mostly has some side effect.The life-span that enters aged society and people along with China is more and more longer, and the patient who suffers from osteoporosis can be more, and this will be a serious social problem.

Summary of the invention

The technical problem to be solved in the present invention is the deficiency that overcomes the medicine of the pharmaceutical composition of existing treatment osteoporosis, and a kind of pharmaceutical composition for the treatment of osteoporosis is provided.

The technical scheme of a kind of pharmaceutical composition for the treatment of osteoporosis of the present invention is achieved in that a kind of pharmaceutical composition for the treatment of osteoporosis, in weight portion, its component is: 10～20 parts of Rhizoma Drynariae, 10～20 parts of the Cortexs Eucommiae, 10～20 parts of the Radixs Astragali, 6～14 parts of Radix Dipsacis, 6～14 parts of Fructus Ligustri Lucidi, 6～14 parts of Semen Cuscutae, 6～14 parts of Radix Morindae Officinaliss, 4～8 parts of Herba Epimedii, 6～14 parts of Herba Pyrolaes, 6～14 parts of Fructus Corni, 6～14 parts of Fructus Lycii, 6～14 parts of Cortex Acanthopanciss.

And the weight portion of described pharmaceutical composition is preferably: 12～18 parts of Rhizoma Drynariae, 12～18 parts of the Cortexs Eucommiae, 12～18 parts of the Radixs Astragali, 8～12 parts of Radix Dipsacis, 8～12 parts of Fructus Ligustri Lucidi, 8～12 parts of Semen Cuscutae, 8～12 parts of Radix Morindae Officinaliss, 5～7 parts of Herba Epimedii, 8～12 parts of Herba Pyrolaes, 8～12 parts of Fructus Corni, 8～12 parts of Fructus Lycii, 8～12 parts of Cortex Acanthopanciss.

Optimum weight part of described pharmaceutical composition is: 15 parts of Rhizoma Drynariae, 15 parts of the Cortexs Eucommiae, 15 parts of the Radixs Astragali, 10 parts of Radix Dipsacis, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Radix Morindae Officinaliss, 6 parts of Herba Epimedii, 10 parts of Herba Pyrolaes, 10 parts of Fructus Corni, 10 parts of Fructus Lycii, 10 parts of Cortex Acanthopanciss.

Described pharmaceutical composition, deficiency of YIN person removes Radix Morindae Officinalis, Herba Epimedii partially, adds 22～40 parts of Herba Ecliptaes.

The dosage form of pharmaceutical composition of the present invention can be the medically acceptable dosage forms such as capsule, tablet, spray, decoction, and their preparation method, supplementary product consumption are undertaken by existing common process.

The present invention also comprises the application of aforementioned pharmaceutical compositions in the medicine of preparation treatment osteoporosis.

In pharmaceutical composition prescription of the present invention:

Rhizoma Drynariae, another name monkey Rhizoma Zingiberis Recens, monkey Rhizoma Zingiberis Recens, Shi Maojiang, Shi An, Cortex Ampelopsis Aconitifoliae Radicis, stone Rhizoma Alpiniae Officinarum, delevay drynaria, Fortune's Drynaria Rhizome, broken benefit, tree Scolopendra, DIWUGONG, yellow parthenocissus, partridge chickens wing, Radix scopoliae sinensis, the broken benefit of meat, monkey palm Rhizoma Zingiberis Recens, Shi Lian, Rhizoma Zingiberis Recens, stone palm, Mao Jiang, drynaria baronii, rock Rhizoma Zingiberis Recens.Composition: Drynaria fortunei(Kunze) J.Smith rhizome is starch-containing 16.4%, glucose 5.37%, also containing naringin.Function cures mainly: the kidney invigorating bone strengthening, continues and hinder pain relieving; For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.1. " property of medicine opinion ": " poison in main bone, wind blood pain, five kinds of over strain six types of severe debility disease, mouthful (one makes " foot ") hands is not received, upper heat and lower cold." 2. " Japan hanako materia medica ": " controls malignant boil, loses rotten meat, parasite killing." 3. " Kaibao Bencao ": " main removing blood stasis, hemostasis, benefit is traumaticd fracture." 4. " book on Chinese herbal medicine just ": " treats the bone poison of being possessed, wind heat pain, or diseases caused by exogenous pathogenic factor rheumatism, so that the weak pain of two flaccidity of the lower limbs." 5. " book on Chinese herbal medicine is stated ": " controls lumbago migratory arthralgia, and apoplexy arthroncus of knee contraction gas card, has loose bowels, and drenches seminal emission, proctoptosis." 6. " Guangxi Chinese medicinal herbal ": " controls infantile malnutrition." 7. " Traditional Chinese Medicine in Sichuan will ": " lets out wet, stimulates the menstrual flow.″

The Cortex Eucommiae, is Eucommiaceae plant, has another name called think of celestial being, think of secondary, wooden silk floss, Mian, Shi Sixian, pulls a skin, a gross weight, a jade skin, silk flosssilk wadding skin, and medicinal part is the bark of the Eucommiaceae plant Cortex Eucommiae.Function cures mainly: the Cortex Eucommiae is warm in nature, and sweet in the mouth has invigorating the liver and kidney, strong waist knee joint, bone and muscle strengthening, antiabortive effect.The Cortex Eucommiae has regulating action in various degree to immune system, hormonal system, central nervous system, blood circulation and urinary system, the excited Pituitary Adrenal cortex system of Cortex Eucommiae energy, adrenal cortex reinforcing function.1. " herbal classic ": " main pain along the spinal column, invigorating middle warmer benefit vital essence, hard muscles and bones, Qiang Zhi, wet except itching under the moon, dribbling urination.In " 2. " not Lu ": " main foot, ache, do not want to trample ground." 3. " property of medicine opinion ": " controls the cold buttocks lumbago of kidney, waist disease people void and stiffness of the body is straight, and wind is also.Unfavorable adding of waist and use it." 4. " Japan hanako materia medica ": " controls impairment of the kidney caused by overstrain, spinal column contraction.Be used as medicine and process use." 5. Wang Haogu: " profit liver is dry, and tonifying liver is through wind void." 6. " book on Chinese herbal medicine just ": " stops little water nocturnal emission, warm uterus, antiabortive gas." 7. " beautiful Chinese catalpa medicine solution ": " liver and kidney tonifying, nourishing muscle and tendon bone, goes to joint wet excessive.Control soreness of waist and knee joint, the contracture of lower limb foot." 8. " book on Chinese herbal medicine is new again ": " fills biceps, Yang path strenghtening.″

The Radix Astragali, another name Radix Astragali, continuous stilbene, the continuous Radix Astragali, the cotton Radix Astragali, Radix astragali, Radix Astragali, arrow stilbene, the arrow Radix Astragali etc., medicinal part is dry of the universe of leguminous plant Radix Astragali or Radix Astagali.Composition: saponin, flavone etc.; Saponin main component is Radix Astragali saponin I, II, and Radix Astragali is separately containing Radix Astragali saponin A, B, and Radix Astagali is separately containing Radix Astragali saponin IV, soybean saponin I; In flavone, main component is formononetin and calycosin etc.; Still containing aminoacid, betanin etc.; Radix Astagali is also containing astragalus polysaccharides I, II, III etc.Function cures mainly: enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely; But table excess pathogen is contained, retention of dampness due to stagnation of QI, food stagnation is stagnated, carbuncle from the beginning of or burst after the excess syndrome such as pyretic toxicity Shang Sheng, and hyperactivity of YANG due to deficiency of YIN person, must prohibit clothes.

Radix Dipsaci, calls imperial bean, genus folding, synthetism, south grass, Rhizoma seu Herba Elatostematis stewardii, shaven head, and medicinal part is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, because energy " synthetism of continuous folding " is gained the name.Composition: Radix Dipsaci root is containing alkaloid, volatile oil, and Radix Dipsaci root is containing Radix Dipsaci alkali and volatile oil.Function cures mainly: invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating; Control aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer is swollen.1. " herbal classic ": " main typhoid fever, tonifying for the deficiency, incised wound, carbuncle and ulcer, folding falls, reuniting the fractured tendons and bones, married woman's breast is difficult, takes for a long time physical strength profiting." 2. " not Lu ": " main metrorrhagia is leaked blood, incised wound blood internal hemorrhage due to trauma, pain relieving, granulation promoting meat, wrist wound, stagnant blood, lumbago, joint emergency." 3. " property of medicine opinion ": " main wound absolutely, removes all temperature poison, can declare qualcomm meridian." 4. " Japan hanako materia medica ": " helps gas, and blood circulation regulating is mended five kinds of strain and seven kinds of impairment ， Po Disorder knot blood stasis, detumescence poison, and hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, acute mastitis, scrofula, flutters damage, all diseases after married woman is antenatal, yellowish complexion edema due to deficiency, urine reducing, stopping leak essence, hematuria, vaginal bleeding during pregnancy, uterus is cold." 5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " tonifying liver, bone and muscle strengthening, walks meridians, only through in (muscles and bones) ache, antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, the dead a word used in place name that falls, the cough-relieving hemoptysis of coughing, controls red white turbid urine." 6. " this sketch of the southern regions of the Yunnan Province is said ": " controls all innominate toxic swellings, Fructus Myricae rubrae, day all skin ulcers of bubble.″

Fructus Ligustri Lucidi, another name Fructus Ligustri Lucidi reality, Fructus Ilicis Purpureae, quick-fried lattice flea, white beeswax tree, Mus Chinese catalpa.Composition: nuzhenide (nuzhenide), oleuropein (oleuropein), oleanolic acid (oleanolicacid), 4-hydroxyl-B-phenethyl-B-D-glycoside, betulinol (betulin) etc.Function cures mainly: invigorating the liver and kidney, strong waist knee joint; Control yin asthenia generating intrinsic heat, dizziness, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair; Nourishing the liver and kidney, improving eyesight black hair; For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.1. " herbal classic ": " main invigorating middle warmer, settling five organs are supported spirit, except hundred diseases.Clothes are fertile strong for a long time." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " black palpus of hair color, strong rigidity of soft tissues power, the wind of enriching blood that takes more." 3. " detailed outline ": " reinforcing YIN-essence, strong waist knee joint, improving eyesight." 4. " Bencao Jingshu ": " removing heat from blood, beneficial blood." 5. " book on Chinese herbal medicine is just ": " yin nourishing gas, Pingyin fire, separates dysphoria with smothery sensation hectic fever due to YIN-deficiency, and only sweating due to debility, quenches one's thirst, and stranguria with turbid discharge, and metrorrhagia, has blood in stool, hematuria, the erosion of vulva, anal fistula pain.Also clearing away liver-fire, can improving eyesight arresting lacrimation." 3. " book on Chinese herbal medicine is new again ": " replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI.Control lumbago and skelalgia, stimulate the menstrual flow and blood." 7. " Guangxi Chinese medicinal herbal ": " the punish-old people constipation due to insufficiency of defecating.″

Semen Cuscutae, another name Herba cuscutae reality, SEMEN CUSCUTAE, without ma rattan rice rice, Caulis Fibraureae, imperial palpus, trailing plants SIZI, yellow net, Huang Luozi, bean palpus, twine imperial son, yellow SIZI, medicinal part is the seed of convolvulus cuscuta plant or cuscuta japonica Choisy.Composition: the resinous glycoside of Semen Cuscutae, saccharide.Cuscuta japonica Choisy glucoside-containing, retinoid material, its content is calculated as 0.0378% by vitamin A.Soybean Dodder is containing beta-carotene, gamma carotene, 5,6-epoxy-alpha-carotene, taraxanthin and phylloxanthin.Function cures mainly: invigorating the liver and kidney, beneficial marrow, improving eyesight; Control soreness of waist and knee joint, seminal emission, quenches one's thirst, dripping urination, and order is dark.1. " herbal classic ": " main continuous wound absolutely, tonifying for the deficiency, physical strength profiting, fertile strong people, takes improving eyesight for a long time." 2. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " mends artificial satellite's gas, the muscle arteries and veins of helping others." 3. " not Lu ": " supports flesh reinforcing YIN-essence, hard muscles and bones, and stem invasion by pathogenic cold, essence, from going out, is drowned and is had the heeltap, and bitter taste is dry thirsty, and cold blood is for long-pending." 4. " property of medicine opinion ": " controls man woman cold caused by deficiency, and sperm adding and marrow healthing, goes pain in the lumbar region knee joint cold, and main quenching one's thirst hankered again." 5. " Japan hanako materia medica ": " mends five kinds of strain and seven kinds of impairment, controls and lets out essence, hematuria, profit cardiopulmonary.The dirty wind void of " 6. king accounts for well: " tonifying liver." 7. " Shandong Chinese medicine ": " controls married woman Chang Xi miscarriage.″

Radix Morindae Officinalis, another name bar halberd, Radix Morindae Officinalis, rabbit intestinal.Medicinal part is the root of Maguireothamnus speciosus Radix Morindae Officinalis.Composition: root is containing anthraquinone, flavone compound.Function cures mainly: kidney-replenishing, strengthening bone and muscle, wind-damp dispelling.Control sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint.1. " herbal classic ": " main strong wind pathogen, impotence does not rise, bone and muscle strengthening, settling five organs, invigorating middle warmer increases will QI invigorating." 2. " not Lu ": " treats women's head-ornaments urticaria, phase dragging pain in lower abdomen and the moon, and the therapeutic method to keep the adverse QI flowing downwards, mends five kinds of over strain, benefit essence." 3. " property of medicine opinion ": " controlled man's sexual intercourse in dream and let out essence, reinforcing YIN-essence, and except women's head-ornaments apoplexy, the main therapeutic method to keep the adverse QI flowing downwards, strong wind blood leprosy." 4. " Japan hanako materia medica ": " settling five organs, centering gas, except a wind cutting.Treat edema." 5. " detailed outline ": " controls beriberi, goes wind disease, the sea of enriching blood." 6. " it is former that book on Chinese herbal medicine is asked ": " reduces phlegm, and controlling coughs breathes heavily, dizzy, have loose bowels, and lack of appetite." 7. Guangzhou army " conventional Chinese herbal medicine handbook ": " kidney invigorating and YANG supporting, bone and muscle strengthening, wind-damp dispelling.Control the waist foot of suffering from a deficiency of the kidney unable, flaccidity syndrome and arthralgia syndrome paralysis, rheumatic ostalgia, neurasthenia, impotence and seminal emission, premature ejaculation, insomnia; Women is sterile.″

Herba Epimedii, another name Herba Epimedii, Herba Epimedii, celestial spirit are adjoined, Herba Epimedii, abandon cane grass, thousand liang of gold, dry chicken muscle, Rhizoma Coptidis ancestral, Epimedium, Birdfoot, Herba Epimedii, stable pestle, three furculas, Herba Saniculae lamelligerae, Rhizoma Smilacis Chinensis, and medicinal part is the stem and leaf of Berberidaceae plant Herba Epimedii, Epimedium brevicornum or arrow leaf Herba Epimedii.Composition: Herba Epimedii stem, leaf are containing icariine, and leaf is still containing volatile oil, ceryl alcohol, 1 alkane, plant sterol, tannin, oils and fats.Fatty acid in fatty oil has Palmic acid, stearic acid, oleic acid, linoleic acid.Function cures mainly: kidney invigorating and YANG supporting, expelling wind and removing dampness; Control sexual impotence erectile problem, dribbling urination, muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.1. " herbal classic ": " main impotence is hindered absolutely, pains in the penis.Diuresis, physical strength profiting, Qiang Zhi." 2. " not Lu ": " hard muscles and bones.Scrofula, red carbuncle disappear; Skin ulcer is arranged at bottom, washes, and goes out worm." 3. " Japan hanako materia medica ": " controls all cold wind consumptive disease, mends waist knee joint, heart tonifying power, and husband is exhausted, and sun does not rise, the exhausted cloudy loss of fecundity of woman, muscles and bones contraction is anxious, and extremity are not appointed, old man's dusk octogenarian, the middle age is forgetful." 4. " Elementary Medicine ": " the kidney invigorating void, supporing yang.Control hemiplegia hands and feet caused by paralysis, extremity munbness.″

Herba Pyrolae, another name Herba pyrolae japonicae, Herba Pyrolae, deer peace tea, Herba pyrolae japonicae, checkerberry, Pyrola rotundifolia ssp.chinensis, Herba Polygalae Telephioidis, medicinal part is the herb of polygonaceae plant halberd leaf knotweed.Composition: Pyrolin is 2,5-orcin (2,5-dihydroxytoluene), kaempferol-3-O-glycoside (kaempfer-ol-3-O-glucoside), Quercetin-3-O-glycoside (quercetin-3-O-gluco-Side) etc.Function cures mainly: wind-damp dispelling, bone and muscle strengthening, hemostasis; For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.

Fructus Corni, another name another name for Sichuan Province Zao, Qi reality, Mus arrow, chicken foot, Fructus Corni, real Fructus Jujubae, meat Fructus Jujubae, Fructus Corni, medicine Fructus Jujubae, Fructus Jujubae skin, medicinal part is the sarcocarp of Cornaceae plant Fructus Corni.Composition: Fructus Corni tan hair (cornus-tannin) 1,2,3[1], Fructus Corni tannin 1 is that different terchebin (isoterchebin) [2] has another name called Pedicellus et Pericarpium Trapae and belongs to tannin (trapain) [4], Fructus Corni tannin 2 is new miterwort element II (tel-limagrandin II) [2], and Fructus Corni tannin 2 is new miterwort element I (tellima-grandin I) etc.Function cures mainly: invigorating the liver and kidney, and arresting seminal emission gas, Gu collapse; Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse; Liver and kidney tonifying, essence astringing and desertion stemming.Quench one's thirst for vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse, interior-heat; Warming the liver the kidney invigorating, except a wind cutting, only menorrhagia, controls senile frequent micturition.1. " herbal classic ": " pathogen cold and heat under the main heart, warming middle-JIAO, by cold-damp numbness, go three worms." 2. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " primordial qi strengthening gas, secret essence." 3. " not Lu ": " the intestines and stomach ailment said due to cold or exposure, cold and heat hernia abdominal mass, wind syndrome of head, pathogenic wind goes, nasal obstruction, icteric sclera, deafness, pimples, warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, perspires, reinforcing YIN-essence, benefit essence, settling five organs, logical nine orifices, only normal urination, improving eyesight, brute force." 4. " property of medicine opinion ": " controls brain osteodynia, and only month water is indefinite, the kidney invigorating gas; Xing Yangdao, adds marrow, treats tinnitus, except skin ulcer on face, and the diaphoresis of main energy, only old man's urine does not save." 5. " Japan hanako materia medica ": " warms up waist knee joint, helps water dirty, except a wind cutting, cuts one by one gas, and broken Disorder knot, controls wine Zha." 6. " pearl sac ": " warming the liver." 7. " it is former that book on Chinese herbal medicine is asked ": " be chronic diarrhea only, the fever and sweating of having a guilty conscience.″

Fructus Lycii: another name Gou Qizi, Fructus Lycii red real, Radix Betae is sub, FRUCTUS LYCII BARBARI, Canis familiaris L. milk, dark purple green pepper, Chinese holly hoof, FRUCTUS LYCII, frame, Chinese holly eggplant eggplant, red ear pendant, blood Fructus Lycii, Chinese holly ground bud, Fructus Lycii bean, blood Fructus Lycii, fructus lycii sinensis, medicinal part is the mature fruit of matrimony vine of solanaceae plant or lycium barbarum.Composition: carotene, lycium barbarum polysaccharide, monosaccharide, betanin, fatty acid, proteins and peptides, vitamin B1, vitamin B2, vitamin B6, vitamin C, 18 seed amino acids (containing 8 kinds of essential amino acids), trace element (calcium, zinc, magnesium, ferrum, manganese, phosphorus etc.).Function cures mainly: nourishing the liver and kidney, beneficial intensive culture blood, improving eyesight removing nebula, nourishing the lung to arrest cough; Cure mainly the atrophic debility of bones of suffering from a deficiency of the kidney, impotence and seminal emission, fertility for a long time, senilism senilism, early whitening of beard and hair, blood deficiency and yellow complexion, puerperal, breast was few, poor vision, interior external oculopathy eye, interior-heat is quenched one's thirst, consumptive fever hectic fever due to YIN-deficiency, chronic consumptive disease cough, the diseases such as the few expectorant of dry cough.

Cortex Acanthopancis, another name CORTEX ACANTHOPANACIS, grain rice skin, Radix Tetrastigmatis Obovati skin, medicinal part is for being the root bark such as Araliaceae slender acanthopanax or Acanthopanax sessiliflorus(Rupr.et Maxim.) Seem., Radix Et Caulis Acanthopanacis Senticosi, rough leaf slender acanthopanax, acanthopanax verticillatus Hao.Composition: acanthopanax gracilistylus root bark is containing Syringin (syringin), eleutheroside (eleutheroside) B1, be different Chun Piding-alpha-D-glucose glycoside (isofraxidin-α-D-glucoside), dextrorotation sesamin (sesamin), 16 Alpha-hydroxies-(-)-shell pine-19-acid [16 α-hydroxy-(-)-kauran-19-oic acid) [2], cupreol (β-sitosterol), cupreol glycoside (β-sitosterol glucoside), stearic acid (stearc acid) [1] [1], Palmic acid (palmitic acid), linolenic acid (linolenic acid) and vitamin A, B1 etc. [3].Also comprise volatilization stain, inside have the compositions [3] such as 4-Methyl Salicylaldehyde (4-methyl salicylaldehyde).Acanthopanax sessiliflorus(Rupr.et Maxim.) Seem. root and root bark are containing left-handed sesamin, left-handed Savinin (savinin) [4], also containing acanthoside (acanthoside) A, B, C, D, K2, K3[5-7], wherein the structure of glycoside A and glycoside C it be unclear that, glycoside B and glycoside D are respectively single glycoside and two glycosides of syringaresinol (syrinaresinol), they all belong to lignan's class, and glycoside K2 and glycoside K3 belong to triterpenes.Again containing cupreol, (daucosterin (is cupreol glycoside to daucosterol, stigmasterol (stig-masterol), Lay oil sterol (campesterol) [7,8], depth of water polysaccharide and alkaline polysaccharide [9], cardiotonic glycoside and trace volatile oil [10].Function cures mainly: wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt; Control anemofrigid-damp arthralgia, muscles and bones contraction is anxious, lumbago, sexual impotence, flaccidity of the lower limbs, children's's walking retardation in children, edema, beriberi, skin ulcer cellulitis toxic swelling, traumatic injury impairment caused by overstrain.1. " herbal classic ": " main trusted subordinate's hernia, stomachache, QI invigorating Liao lame, children's can not go, the erosion of the vulva of cellulitis skin ulcer." 2. " not Lu ": " treats man's impotence, wet under capsule, dribbling urination, and woman's pudendal pruritus and pain along the spinal column, a little less than bipod pain numbness wind, five slow weakness with emaciation, invigorating middle warmer benefit essence, hard muscles and bones, Qiang Zhiyi." 3. " property of medicine opinion ": " can break by aversion to wind blood, and extremity are unsuccessful, and harmful wind is hurted sb.'s feelings, weak foot, and buttocks waist, main blood stasis for many years, at musculus cutaneus, is controlled numbness wet interior not enough, main weakness with emaciation, children's can not go for three years old." 4. " Japan hanako materia medica ": " improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, controls apoplexy joint contraction anxious, mends five kinds of strain and seven kinds of impairment." 5. " detailed outline)): " dispelling the wind and dampness pathogens flaccidity syndrome and arthralgia syndrome, strengthening bone and muscle." 6. " book on Chinese herbal medicine is new again ": " eliminating phlegm and removing dampness, supports kidney benefit essence, removes emaciation due to emotional upset water, and reason beriberi lumbago, controls all poison of skin ulcer scabies." 7. " Shaanxi Chinese herbal medicine ": " promoting blood circulation and detumescence.Dispelling the wind and dampness pathogens arthralgia, eczema scrotum, traumatic injury, edema, dysuria." " be " Yunnan Chinese herbal medicine " 8.: " control traumatic injury, fracture, sore, malaria.″

The traditional Chinese medical science is thought kidney governing bones, raw marrow, thinks that the whether strong of bone and the power of kidney have direct relation, and kidney qi is filled and contained that bone marrow is full, and muscles and bones is powerful; Deficiency of kidney-essence, bone marrow inanition, just there will be soreness of the waist and knees, even the foot flaccidity symptom such as can not take action.

Pharmaceutical composition of the present invention is for the patients' such as lower limb back pain, two hip pain, osteoporosis treatment, and taking the strong muscle of the kidney invigorating as main, in side, Rhizoma Drynariae, the Cortex Eucommiae, the Radix Astragali are monarch drug, invigorating the liver and kidney, strong waist knee joint, stimulates the menstrual flow and blood; Radix Dipsaci, Fructus Ligustri Lucidi, Semen Cuscutae, Radix Morindae Officinalis etc. are ministerial drug, expelling wind and removing dampness, the pain of dispelling blood stasis dispelling; Herba Epimedii is for making medicine, nourishing the liver and kidney, beneficial intensive culture blood.The present invention has passed through clinical proof, and medication is good, have no side effect.

Detailed description of the invention

Embodiment 1

Treat a pharmaceutical composition for osteoporosis, its composition comprises: Rhizoma Drynariae 100g, Cortex Eucommiae 100g, Radix Astragali 100g, Radix Dipsaci 60g, Fructus Ligustri Lucidi 60g, Semen Cuscutae 60g, Herba Ecliptae 220g, Herba Pyrolae 60g, Fructus Corni 60g, Fructus Lycii 60g, Cortex Acanthopancis 60g.

Preparation method: take above each raw material by proportional quantity, dry, pulverize, cross 80 mesh sieves, soak 2 months with 50 degree rice wine 40kg, filter and remove residue, gets supernatant and adds the penetrating agent of conventional amount used and antiseptic to shake even spray.

Embodiment 2

Treat a pharmaceutical composition for osteoporosis, its composition comprises: Rhizoma Drynariae 200g, Cortex Eucommiae 200g, Radix Astragali 200g, Radix Dipsaci 140g, Fructus Ligustri Lucidi 140g, Semen Cuscutae 140g, Radix Morindae Officinalis 140g, Herba Epimedii 80g, Herba Pyrolae 140g, Fructus Corni 140g, Fructus Lycii 140g, Cortex Acanthopancis 140g.

Preparation method: take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), the cane sugar powder that adds conventional amount used, mixes granulation.

Embodiment 3

Treat a pharmaceutical composition for osteoporosis, its composition comprises: Rhizoma Drynariae 120g, Cortex Eucommiae 120g, Radix Astragali 120g, Radix Dipsaci 80g, Fructus Ligustri Lucidi 80g, Semen Cuscutae 80g, Herba Ecliptae 400g, Herba Pyrolae 80g, Fructus Corni 80g, Fructus Lycii 80g, Cortex Acanthopancis 80g.

Preparation method: take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), the magnesium stearate adjuvant that adds conventional amount used, technique becomes tablet routinely, specification 0.5g/ sheet.

Embodiment 4

Treat a pharmaceutical composition for osteoporosis, its composition comprises: Rhizoma Drynariae 180g, Cortex Eucommiae 180g, Radix Astragali 180g, Radix Dipsaci 120g, Fructus Ligustri Lucidi 120g, Semen Cuscutae 120g, Radix Morindae Officinalis 120g, Herba Epimedii 70g, Herba Pyrolae 120g, Fructus Corni 120g, Fructus Lycii 120g, Cortex Acanthopancis 120g.

Preparation method: take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct collecting decoction 1.5 hours, filter, filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), adds the dextrin adjuvant of conventional amount used, technique routinely, make capsule, 0.5g/ grain.

Embodiment 5

A kind of pharmaceutical composition for the treatment of osteoporosis, in weight portion, its component is: Rhizoma Drynariae 150g, Cortex Eucommiae 150g, Radix Astragali 150g, Radix Dipsaci 100g, Fructus Ligustri Lucidi 100g, Semen Cuscutae 100g, Radix Morindae Officinalis 100g, Herba Epimedii 60g, Herba Pyrolae 100g, Fructus Corni 100g, Fructus Lycii 100g, Cortex Acanthopancis 100g.

Preparation method: take above each raw material, decoct with water three times, add the water of doubling dose at every turn, decoct at every turn one 30 minutes, filter, merging filtrate, technique is made decoction routinely.

Experimental example: pharmaceutical composition of the present invention is for the clinical efficacy of patients with osteoporosis

Experiment material: pharmaceutical composition prepared by the embodiment of the present invention 5.

Experiment place: Pubei, Guangxi local hospital.

1, physical data: 2008---since 2014 05 month, in the situation that patient is voluntary, accepted outpatient service postoperative patient 80 examples for medical treatment, wherein minimum 60 years old of age, maximum 85 years old, the course of disease was the shortest 1 year, the longest 20 years; Be divided into matched group and treatment group, two groups of patients in mean age, the course of disease, the state of an illness without significant difference.

2, clinical efficacy evaluation criteria: (1) cures: clinical symptoms all disappears, recovers normal activity function, and union of fracture or compression vertebral body recover.(2) take a turn for the better: clinical symptoms is most of to disappear, union of fracture or delayed union, Vertebral Compression is without increasing the weight of, and osteoporosis symptom is improved, and recovers daily routines.(3) invalid: main clinic symptoms, sign, movable function and osteoporosis are without improving or increasing the weight of.

3, Therapeutic Method:

Matched group: 20 examples, patients with osteoporosis, cures by traditional method, within 4 weeks, is 1 course for the treatment of, is used in conjunction 3 courses for the treatment of;

Treatment group: 80 examples, patients with osteoporosis, takes the decoction that the embodiment of the present invention 5 is boiled into, every day 2 times, each 100mL, oral; Within 4 weeks, be 1 course for the treatment of, be used in conjunction 3 courses for the treatment of.

4, clinical effectiveness

Group	Number of cases	Cure	Take a turn for the better	Invalid	Total effective rate
						Treatment group	80	58	19	3	96.2％
Matched group	20	8	8	4	72.8％

6, untoward reaction: therapeutic process is showed no the untoward reaction relevant to medicine.

7, result shows: 5 groups of medications of the embodiment of the present invention 12 weeks, to patients with osteoporosis total effective rate 96.2%, obviously exceed 80% of matched group, and cure rate, the effective percentage for the treatment of group all obviously exceed matched group.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.

Claims

1. a pharmaceutical composition for the treatment of osteoporosis, is characterized in that: this pharmaceutical composition is to be made up of the raw material of following weight parts:

10～20 parts of Rhizoma Drynariae, 10～20 parts of the Cortexs Eucommiae, 10～20 parts of the Radixs Astragali, 6～14 parts of Radix Dipsacis, 6～14 parts of Fructus Ligustri Lucidi, 6～14 parts of Semen Cuscutae, 6～14 parts of Radix Morindae Officinaliss, 4～8 parts of Herba Epimedii, 6～14 parts of Herba Pyrolaes, 6～14 parts of Fructus Corni, 6～14 parts of Fructus Lycii, 6～14 parts of Cortex Acanthopanciss.

2. the pharmaceutical composition for the treatment of as claimed in claim 1 osteoporosis, is characterized in that: this pharmaceutical composition is to be made up of the raw material of following weight parts:

12～18 parts of Rhizoma Drynariae, 12～18 parts of the Cortexs Eucommiae, 12～18 parts of the Radixs Astragali, 8～12 parts of Radix Dipsacis, 8～12 parts of Fructus Ligustri Lucidi, 8～12 parts of Semen Cuscutae, 8～12 parts of Radix Morindae Officinaliss, 5～7 parts of Herba Epimedii, 8～12 parts of Herba Pyrolaes, 8～12 parts of Fructus Corni, 8～12 parts of Fructus Lycii, 8～12 parts of Cortex Acanthopanciss.

3. the pharmaceutical composition for the treatment of as claimed in claim 2 osteoporosis, is characterized in that: this pharmaceutical composition is to be made up of the raw material of following weight parts:

15 parts of Rhizoma Drynariae, 15 parts of the Cortexs Eucommiae, 15 parts of the Radixs Astragali, 10 parts of Radix Dipsacis, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Radix Morindae Officinaliss, 6 parts of Herba Epimedii, 10 parts of Herba Pyrolaes, 10 parts of Fructus Corni, 10 parts of Fructus Lycii, 10 parts of Cortex Acanthopanciss.

4. the pharmaceutical composition for the treatment of osteoporosis as described in claim 1～3, is characterized in that: deficiency of YIN person removes Radix Morindae Officinalis, Herba Epimedii partially, adds 22～40 parts of Herba Ecliptaes.

5. the application of the pharmaceutical composition described in any one in the medicine of preparation treatment osteoporosis in claim 1～4.