CN100459993C - Compound Chinese medicine for treating bone stitch and its preparation - Google Patents
Compound Chinese medicine for treating bone stitch and its preparation Download PDFInfo
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- CN100459993C CN100459993C CNB200610085406XA CN200610085406A CN100459993C CN 100459993 C CN100459993 C CN 100459993C CN B200610085406X A CNB200610085406X A CN B200610085406XA CN 200610085406 A CN200610085406 A CN 200610085406A CN 100459993 C CN100459993 C CN 100459993C
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese patent medicine in the form of capsule, tablet, or particle for treating spur pain is prepared from 11 Chinese-medicinal materials including dodder seed, schisandra fruit, epimedium, tuckahoe, etc. Its preparing process is also disclosed.
Description
Technical field
What the present invention relates to is a kind of pharmaceutical preparation and preparation method thereof, more particularly, relates to a kind of compound Chinese patent medicine for the treatment of bone stitch and preparation method thereof.A kind of compound Chinese patent medicine for the treatment of bone stitch of the present invention claims " twinge gram " again.
Background technology
Wound, fracture, hyperosteogeny, osteoporosis are the common property of orthopaedics frequently-occurring disease, and its annual morbidity accounts for 10% of population total amount, and promptly annual domestic patient we can say that just up to more than 100,000,000 person-times market is quite big to the demand of this type of medicine.In addition, owing to be subjected to the influence of factors such as vehicle accident, population growth, life stress, the market demand is the impetus that increases year by year.
The clinical of hyperosteogeny is divided into: hyperosteogeny of cervical vertebra, lumbar vertebra hyperosteogeny, knee joint hyperosteogeny.Aspect doctor trained in Western medicine, major part all is to treat with analgesic and hormone at present, to alleviate the sick body symptom.In recent years, orthopaedics Chinese medicine has also won certain market in the world, is accompanied by abroad the understanding to the Western medicine toxic and side effects, and the demand of natural medicine is also being increased year by year.The medicine of treatment hyperosteogeny has JINGFUKANG, GUXIAN PIAN, bony spur spirit, bone spur pain-eliminating liniment or the like both at home and abroad at present, and the said goods because of the limitation of its prescription theory, we can say that curative effect is average, the price height.Aspect the traditional Chinese medical science, all be to remove some slight illness with relaxing muscles and tendons to promote blood circulation, expelling wind and removing dampness.The prescription that most of traditional Chinese medical science are left all is to use some following traditional Chinese medicines, and as the Radix Paeoniae Alba, Fructus Chaenomelis, Radix Glycyrrhizae, Sanguis Gallus domesticus knee joint, Radix Clematidis, Radix Puerariae, Fructus Lycii, the Cortex Eucommiae, Niu Xi, Radix Angelicae Sinensis, Retinervus Luffae Fructus, Ramulus Uncariae Cum Uncis or the like, and effect can only solve patient surface pain problem.
Summary of the invention
The objective of the invention is provides a kind of compound Chinese patent medicine for the treatment of bone stitch and preparation method thereof at above-mentioned weak point, we draft under the theoretical direction of Chinese medicine " kidney governing bones ", make sclerotin obtain the filling of material and repair, fundamentally solve the pain of bony spur.
The present invention is prescription under the theory of Chinese medicine " kidney governing bones ", thinks that bony spur is owing to suffer from a deficiency of the kidney, and can not give birth to that marrow fills bone and the regression that causes bone so the present invention solves patient's the body constitution of suffering from a deficiency of the kidney earlier, is effected a radical cure the pain that bony spur causes from the source.The present invention can greatly improve patient's quality of life, satisfies patient's urgent needs.
Hyperosteogeny belongs to the traditional Chinese medical science " arthromyodynia " category, and good sending out in 35～70 years old age bracket can be described as a kind of normal physiological phenomena.Because motion and work are many, wearing and tearing impelling joint, joint produces the degeneration bone and becomes, about 80% people more or less hyperosteogeny can occur more than 60 years old.Because China just progressively enters the society of aging, so treatment hyperosteogeny, the medicine that alleviates affected part pain are had great demand.
Hyperosteogeny also is bony spur, or title hyperosteogeny, motherland's medical science is referred to as " rheumatism involving the bone ", it is at the vertebra edge or the edge, joint, the outgrowth sclerotin of articular surface and apophysis place is a kind of performance of osteoarthritis, if tissue such as the nerve around the outgrowth sclerotin compressing, blood vessel or when influencing joint motion, corresponding symptoms can appear, i.e. hyperosteogeny or title hypertrophy osteoarthropathy.Hyperosteogeny is found in the heavy burden joint at any position of human body, and is the most common with cervical vertebra, calcaneus, lumbar vertebra, kneecap joint, is one of common ailment of middle-aged and old.Its main clinical manifestation is an affected part pain, and companion acid is expanded numb, and the patient quite thinks hardship, as calcanean spur whenever just upright, severe pain is unbearably when just walking; Cervical vertebra bony spur can cause neck, shoulder, arm, back radiated pain, and headache is felt sick, and is dizzy, dampings off.
The traditional Chinese medical science is thought " kidney governing bones, liver governing tendons, muscle invest bone ", and cervical spondylosis, prolapse of lumbar intervertebral disc, hyperosteogeny and osteoporosis diseases all are the pathological changes of muscles and bones.Middle-aged and elderly people is because hepatic and renal function decline, and suffering from a deficiency of the kidney can not nourishing bone, and deficiency of liver-blood is with nourishing muscle and tendon, adds that soaking of wind-cold damp pathogen attack, or the wound strain, causes qi-blood disharmony, blockage of main and collateral channels, and various symptoms such as pain discomfort, the numb and movable obstruction of body appear in stagnation of QI and blood may bring about pain.
The clinical of hyperosteogeny is divided into: hyperosteogeny of cervical vertebra, lumbar vertebra hyperosteogeny, knee joint hyperosteogeny.Aspect doctor trained in Western medicine, major part all is to treat with analgesic and hormone at present, to alleviate the sick body symptom.Aspect the traditional Chinese medical science, all be to remove some slight illness with relaxing muscles and tendons to promote blood circulation, expelling wind and removing dampness.The prescription that most of traditional Chinese medical science are left all is to use some following traditional Chinese medicines, and as the Radix Paeoniae Alba, Fructus Chaenomelis, Radix Glycyrrhizae, Sanguis Gallus domesticus knee joint, Radix Clematidis, Radix Puerariae, Fructus Lycii, the Cortex Eucommiae, Niu Xi, Radix Angelicae Sinensis, Retinervus Luffae Fructus, Ramulus Uncariae Cum Uncis or the like, and effect can only solve patient surface pain problem.We draft under the theoretical direction of Chinese medicine " kidney governing bones ", make sclerotin obtain the filling of material and repair, and fundamentally solve the pain of bony spur.
A kind of compound Chinese patent medicine for the treatment of bone stitch and preparation method thereof is to take following scheme to realize:
A kind of compound Chinese patent medicine that is used for the treatment of bone stitch is characterized in that the compound Chinese patent medicine agent that it is made by following Chinese crude drug raw material by weight ratio:
Fructus Rubi 200～220, Rhizoma Drynariae 88～94, Semen Cuscutae 57～63, Fructus Schisandrae Chinensis 47～52, Fructus Rosae Laevigatae 38～43, Herba Epimedii 28～32, Poria 29～33, Radix Morindae Officinalis 27～31, Herba Cynomorii 18～22, Fructus Cnidii 28～33, Herba Cistanches 27～33.
A kind of compound Chinese patent medicine that is used for the treatment of bone stitch, its pharmaceutical preparation are capsule
A kind of preparation method that is used for the treatment of the compound Chinese patent medicine of bone stitch: press following weight proportion weighing Chinese crude drug raw material:
Fructus Rubi 200～220, Rhizoma Drynariae 88～94, Semen Cuscutae 57～63, Fructus Schisandrae Chinensis 47～52, Fructus Rosae Laevigatae 38～43, Herba Epimedii 28～32, Poria 29～33, Radix Morindae Officinalis 27～31, Herba Cynomorii 18～22, Fructus Cnidii 28～33, Herba Cistanches 27～33;
After above-mentioned load weighted Chinese crude drug raw material selected, cleans, twice of 70～90% alcohol heating reflux of 7～12 times of amounts of adding, each 0.5～2.5 hour, filter, the filtrate concentrate drying, pulverize Chinese medicine extract, granulate after crossing 80～120 mesh sieves, divide the capsule of packing into, or the adding pharmaceutic adjuvant is pressed into tablet or is distributed into granule.
Described Chinese medicine extract and pharmaceutic adjuvant weight proportion are 1:0.5～4.
Described pharmaceutic adjuvant is selected a kind of or mixture in Pulvis Talci, microcrystalline Cellulose, starch, magnesium stearate, cane sugar powder, the dextrin for use.
The theory of Chinese medicine " kidney governing bones " thinks, bony spur is owing to suffer from a deficiency of the kidney, and can not give birth to that marrow fills bone and the regression that causes bone, so under this theory, draft we.But Herba Epimedii, Semen Cuscutae kidney-replenishing, dredging DU Meridian arteries and veins in the side, warming the kidney to invigorate YANG is a monarch drug; Rhizoma Drynariae is got it can invigorating the liver and kidney, again can bone and muscle strengthening, and the kidney invigorating bone strengthening, the continuous wound are controlled pain and are ministerial drug; Herba Cistanches has the function of kidney invigorating and YANG supporting, life essence-filling, marrow-benefitting, benefiting essence-blood, loosening bowel to relieve constipation, slow down aging; Radix Morindae Officinalis, warming the kidney to invigorate YANG is arranged, benefit is smart, bone and muscle strengthening, the effect of wind-damp dispelling; But the Herba Cynomorii benefiting essence-blood, moisturize nourishing muscle and tendon and control a little less than the flaccidity; Fructus Rubi, Fructus Schisandrae Chinensis equal attribute temperature sweet in the mouth and acid, it is smart that Fructus Rubi grows, and the Fructus Schisandrae Chinensis hemopoietic though two medicines temperature is not hot not dry, plays the synergism that gentleness is secreted smart nourishing kidney altogether; The Poria tool relieves inflammation or internal heat, the effect of detoxifcation, diuresis, spleen invigorating.
The present invention is totally ten Herba indigoferae Pseudotinctoriae, and its nature,taste and action division is as follows:
Fructus Rubi: Fructus Rubi has another name called that the bubble that tills the land, father-in-law are turned round, the milk mother, is a kind of Chinese medicine of common flat invigorating the liver and kidney.Beginning is stated from " Mingyi Bielu ", is listed in top grade.TAO Hong-Jing is said: " flat, nontoxic, main QI invigorating is made light of one's life by commiting suicide for Fructus Rubi, sweet in the mouth, and order is sent out not white, adopts reality May." amplification on Canon of Materia Medica cloud again: " and Fructus Rubi, rectangular, May green is ripe, and Qin state is a lot of, and Yongxing Hua Zhou also has, and in time, the people adopts and sells in the mountain, and its sour in the mouth is sweet, and outer as Fructus Litchi, Fructus Pruni pseudocerasi is permitted big, and is soft red lovely, loses and adopts a then living maggot." Pharmacopoeia of the People's Republic of China version regulation in 2000 certified products is the fruit of Fructus Rubi (rubus chingii Hu).
The sweet sour tepor of Fructus Rubi, the neutralization of property official report is returned liver, kidney channel, the merit of Bearberry Extract hemostasis.The function the liver and the kidney tonifying, supporing yang reducing urination.Be used for enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea, the cloudy insufficiency of essence of woman etc.Tcm clinical practice is helped in the tonification prescription by Fructus Rubi commonly used.Fructus Rubi is applied to the clinical long history that has, and ancient Chinese medicine doctor all has abundant and enriches.Modern pharmacological research such as anti-aging effects, to the regulating action of reproductive system, to immune effect etc., think Fructus Rubi based on invigorating the liver and kidney, also have arresting seminal emission gas, the effect of reducing urination liquid.Though have invigorating the liver and kidney, arresting seminal emission gas, reducing urination liquid three to act on greatly,, be a kind of good tonic actually based on invigorating the liver and kidney.
Rhizoma Drynariae: Rhizoma Drynariae is the grow nonparasitically upon another plant dry rhizome of Jue class Zhi Wu Tong Herba pteridii latiusculi of perennial Os Draconis section, popular name monkey Rhizoma Zingiberis Recens, hair Rhizoma Zingiberis Recens.Rhizoma Drynariae bitter in the mouth, warm in nature, effect are that the kidney invigorating analgesia, blood circulation-invigorating tendon-strengthening, symplectic bone are cured the wound." property of medicine opinion ": " poison in the main bone, wind blood pain, the five kinds of over strain six types of severe debility disease, a mouthful hands is not received upper heat and lower cold." supplement to the Herbal: " master traumatics fracture, and mends osteomiosis "." Bencao Tujing ": " control and dodge folding muscles and bones trauma ", " again with controlling deafness ", " it is medicinal also to go into married woman's vim and vigour ".Modern pharmacology is analyzed: Rhizoma Drynariae contains liposoluble constituent, flavonoid becomes to grade with other, and its rhizome is starch-containing, glucose, naringin etc.Effects such as bone strengthening, blood fat reducing, heart tonifying and analgesia are arranged.Rhizoma Drynariae is mainly used in controls lumbago due to renal deficiency, the rheumatic lumbago and skelalgia, and the chronic diarrhea of suffering from a deficiency of the kidney, the enuresis, little infantile malnutrition have blood stasis in the abdomen, muscle and tendon injury knochenbruch, congestive edema, pain, alopecia areata, chronic dermatitis and control streptomycin toxicity.
Semen Cuscutae: Semen Cuscutae is a conventional Chinese medicine, is a kind of parasitics plant, be used as medicine with seed, and acrid in the mouth, sweet, property is flat.Return the liver,kidney,spleen warp.The main Liver and kidney, replenishing vital essence to improve eyesight, antidiarrheal of taking a tonic or nourishing food to build up one's health is antiabortive etc.Cure mainly soreness of the waist and knees, sexual impotence, lingering diarrhea, frequent micturition, have a dizzy spell, effect such as visual deterioration, frequent fetal movement, threatened abortion and blood pressure lowering.The Semen Cuscutae beginning is stated from Shennong's Herbal and classifies as top grade." Zhenglei Bencao " draws the speech of Su Song: the ＂ summer gives birth to Seedling such as silk and combines and spread on the vegetation, or the false gas of cloud unrooted and giving birth to, and six, July is solid, superfine as silkworm egg, khaki, JIUYUE are received and are adopted cruelly dried ＂.Li Shizhen (1518-1593 A.D.) is said: many virgin soils of ＂ garden old road, and its son is gone into ground, and nascent have root, and long its root is autotomyed along careless thing, no Ye Youhua, white is little red, and perfume (or spice) is also attacked the people, solid as not plump bean and carefully, yellow skin.Modern study shows that the Semen Cuscutae seed contains Quercetin, astragalin, hyperin.Herb contains the Semen Cuscutae polysaccharide to lymphocyte tool mitogenesis, also contains lecithin and cephalin.Its pharmacological action has effects such as the gonad function of enhancing, raise immunity.
Fructus Schisandrae Chinensis: Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (TrucZ.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd.et wils..Sour in the mouth, warm in nature.Return lung, the heart, kidney channel.The energy convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, mind tranquilizing and the heart calming.Cure mainly the chronic cough dyspnea due to deficiency, emission, frequent urination and enuresis, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, palpitation and insomnia." the medical center bun is wanted ": " allay excitement relieving thirst and restlessness, the dream of emesis peace." " property of medicine bun is wanted ": " treat the nocturnal emission lingering diarrhea." " explaining abstruseness of the canon of materia medica ": " controlling nocturnal emission with astringent drugs, arresting sweating." " solar corona ": " and make eye bright, warming the kidney is controlled wind, and the therapeutic method to keep the adverse QI flowing downwards helps digestion, the cholera rotating disk, and mass beside the umbilicus renal mass cold air, consumer edema, regurgitation, trusted subordinate's flatulence is quenched the thirst, and heat clearing away and restlessness relieving is separated the Kaifeng poison, strengthening bone and muscle." modern study shows that Fructus Schisandrae Chinensis mainly contains volatile ingredient (as australene, benzoic acid etc.), lignanoids (as deoxyschizandrin, schisandrin B etc.), organic acid and glycoside etc.Pharmacological research shows, Fructus Schisandrae Chinensis can obviously prolong pentobarbital sodium length of one's sleep, and anticonvulsant action is arranged; The Fructus Schisandrae Chinensis preparation can promote the hepatic glycogen heteroplasia, can promote hepatic glycogen to decompose, and the phosphorylation process of fructose and glucose is strengthened.And liver injury due to the chemical toxicant had protective effect, aged mouse there is certain function in delaying senility.
Fructus Rosae Laevigatae: Fructus Rosae Laevigatae is the fruit of rosaceous plant Fructus Rosae Laevigatae.Sour in the mouth, puckery, property is flat.Return spleen, kidney, urinary bladder channel.But controlling nocturnal emission with astringent drugs, reducing urination, astringing intestine to stop diarrhea, leukorrhagia stopping.Cure mainly seminal emission, spermatorrhea, the enuresis, frequent micturition, chronic diarrhea, chronic dysentery, nebulousurine, leucorrhea, metrorrhagia, proctoptosis, uterine prolapse." another name for Sichuan Province book on Chinese herbal medicine ": " treat the splenic diarrhea dysentery, end normal urination, arresting seminal emission gas.Clothes make us cold-resistant and make light of one's life by commiting suicide for a long time." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control with the passing of time dysentery, metrorrhagia leukorrhagia, arresting seminal emission spermatorrhea." " book on Chinese herbal medicine is just ": " and emesis blood, epistaxis, born fluid are received sweating due to debility, hold back asthenic fire, beneficial marrow, and strengthening bone and muscle is mended five and is hidden, the gas that nourishes blood, flat cough, Dingchuan is anxious, treats the palpitation with a distress feeling palpitation with fear, and only the splenic diarrhea, dysentery and Xiao Shui can't help." " book on Chinese herbal medicine is newly organized ": " arresting seminal emission is sliding, ends nocturnal emission, the enuresis, kills proglottid of tapeworm." " property of medicine is wanted in the medical center bun ": " tonifying the lung unboiled water and spleen eliminating pathogen in the liver, controlling nocturnal emission with astringent drugs, astringing QI ".Modern study shows that the Fructus Rosae Laevigatae fruit contains citric acid, malic acid.The Fructus Rosae Laevigatae peel contains multiple hydrolysis-type tannin: laevigatin A, B, C, D, E, F, G, agrimonine, preceding cyanidin B-3, sanguiin H-4, long stalk aristin, Herba potentillae kleinianae tannin, agrimonic acid A and B etc.Fructus Rosae Laevigatae has antivirus action: the Embryo Gallus domesticus evidence, the Fructus Rosae Laevigatae decoct is to PR
8Etc. several strains of influenza viruses inhibitory action is arranged.
Herba Epimedii: Herba Epimedii is the stem and leaf of Berberidaceae plant Herba Epimedii Epimedium brevieomum Maxim.Acrid in the mouth, sweet, temperature.Return liver, kidney channel.Kidney invigorating and YANG supporting, strengthening the tendons and bones, expelling wind and removing dampness.Be used for impotence and seminal emission, cold caused by deficiency is sterile, the frequent micturition incontinence, and dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, hemiplegia, extremity are meciless.Shennong's Herbal: " main impotence is hindered extremely, pains in the penis.Diuresis, physical strength profiting, strong will." " Mingyi Bielu ": " and hard muscles and bones, the scrofula that disappears, red carbuncle, skin ulcer is arranged at the bottom, washes, and goes out worm." " Japan hanako materia medica ": " and control all cold wind consumptive disease, mend the waist knee joint, heart tonifying power, the husband is exhausted, and sun does not rise, the exhausted cloudy loss of fecundity of woman, the muscles and bones contraction is anxious, and extremity are not appointed, old man's dusk octogenarian, the middle age is forgetful." " Elementary Medicine book on Chinese herbal medicine ": " and the kidney invigorating void, supporing yang, control the hemiplegia hands and feet caused by paralysis, the extremity munbness." " property of medicine is wanted in the medical center bun ": " mending gate of vitality's Liver and kidney, energy Yang strengthening and life essence tonifying, also cold removing numbness ".Modern study shows that Herba Epimedii contains Herba Epimedii glycoside, organic acid, sugar and trace element.Herba Epimedii is to endocrine effect: 1) Herba Epimedii can promote sexual function to be because gonepoiesis is hyperfunction, after seminal vesicle is full of, and sensation nerve, indirect excitation libido and causing.2) Herba Epimedii main component icariine can obviously promote mouse epididymis and the growth of seminal vesicle childhood, and icariine has the effect of androgen sample.Herba Epimedii is to the influence of function of immune system: 1) kidney deficiency human T-cell quantity, drench rate of rotation, antibody, antigen and reticuloendothelial system phagocytic hypofunction, and treatment all can improve through kidney-reinforcing drugs such as Herba Epimedii.2) studies show that epimedium brevicornum polysaccharide has the effect of enhancing human body immunity function, epimedium brevicornum polysaccharide had both increased spleen antibody-producting cell number by the influence to the spleen antibody-producting cell, promoted each plasma cell to produce antibody again.3) anti-aging effects: Herba Epimedii can be from the old and feeble mechanism of different aspects influence.As influence passage, and prolong trophophase, regulate immunity and excretory system, improve organism metabolism and each organ dysfunction.Can cause old and feeble theory according to the traditional Chinese medical science " the positive deficiency of vital energy ", adopt the rule of treatment of " strengthening the body resistance ", keep normal adrenal cortex function and immunologic function, can postpone ager process and the generation that prevents senile disease.And total flavone glucoside of epimedium has the T cellular immunization of enhancing and B cellular immunization and adrenocortical function, illustrates that the delaying senility function of Herba Epimedii is relevant with functions of immune system.Studies show that Herba Epimedii has. function of resisting osteoporosis.
Poria: Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Sohw) Wolf..Sweet in the mouth, light is flat.GUIXIN, lung, spleen, kidney channel.But promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia." herbal classic ": (Poria) " the contrary gas of the main breast side of body, melancholy is angerd frightened evil, probably throbs with fear, and the heart is the knot pain down, cold and heat stuffy sensation with restlessness, cough with dyspnea, mouthful burnt dry tongue, diuresis.Clothes peace soul is reposed not hungry prolonging life for a long time." " not Lu ": (Poria) " only quench one's thirst, like to sleep, big abdomen drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open the breast internal organs, transfer visceral-qi, cut down the kidney heresy, long cloudy, physical strength profiting is during guarantor god keeps." " property of medicine opinion ": (Poria) " appetizing, preventing or arresting vomiting is contrary, kind tranquilizing mind, main consumptive lung disease expectorant is stopped up, and controls pediatric epilepsy scared, treats trusted subordinate's distension, married woman's pyretic stranguria." " solar corona ": (Poria) " mend five kinds of strain and seven kinds of impairment, antiabortive, warm waist knee joint, happy Fructus Alpiniae Oxyphyllae, only forgetful." amplification on Canon of Materia Medica: (Poria) " merit of row water is many, heart-spleen boosting." " concise exposition on febrile disease ": (Poria) " slow spleen of infiltration." " pearl sac ": (Poria) " oozes and lets out, quench the thirst, cut down the kidney heresy.Urine at most can be just it, puckery then can profit." " medicine origin ": (Poria) " only quench one's thirst, diuresis, the dehumidifying benefit is dry, and blood and middle QI invigorating are main between sharp waist umbilicus.Control urinary obstruction, it is yellow or red and unfavorable to drown." curing mainly secret wanting " cloud, it is with having five: antidiarrheal one is also; Diuresis two also; Loosing the interspaces of skin and muscles three also; Remove deficiency-heat four also; Born fluid five also ".Modern study shows that Poria mainly contains compositions such as polysaccharide, triterpenes, fatty acid.Poria has diuresis, antitumor action, sedation, Poria also have protect the liver, antiinflammatory, antipathogen effect, also influential to gastrointestinal function.Poria is to Immune Effects: the effect that pachyman body (pachyman, carboxymethyl pachyman, hydroxyethyl pachyman) has the enhancing human body immunity function.
Radix Morindae Officinalis: Radix Morindae Officinalis is the root of Maguireothamnus speciosus Radix Morindae Officinalis.Acrid in the mouth, sweet, slightly warm in nature.Return liver, kidney channel.But reinforcing the kidney and supporting YANG, bone and muscle strengthening, expelling wind and removing dampness.Cure mainly impotence due to deficiency of the kidney, the seminal emission premature ejaculation, few abdomen cold type of pain, incontinence of urine, cold womb is infertile, anemofrigid-damp arthralgia, soreness of the waist and knees, rheumatism beriberi." herbal classic ": " main strong wind pathogen, sexual impotence does not rise, bone and muscle strengthening, settling five organs, invigorating middle warmer increases the will QI invigorating." " not Lu ": " and treat women's head-ornaments urticaria, phase dragging pain in lower abdomen and the moon, the therapeutic method to keep the adverse QI flowing downwards is mended five kinds of over strain, and benefit is smart, sharp man." " solar corona ": " settling five organs, centering gas removes a wind cutting, controls pathogen, treats edema." " detailed outline ": " control beriberi, go the wind disease, the sea of enriching blood ".Modern study shows that the Radix Morindae Officinalis root contains anthraquinone component: Rubiadin etc., root bark contain 23 kinds of elements such as zinc, manganese, ferrum, chromium.Modern pharmacological research shows, Radix Morindae Officinalis has strong effect, antiinflammatory action, effect in increasing leukocyte, influence to the accessory sex organ: male castration children tooth rat oral gavage gives Radix Morindae Officinalis decoct 30g/kg every day, continuous 15 days, seminal fluid capsule, prostate, preputial glands and levator ani weight all there is not obvious influence.The prompting Radix Morindae Officinalis does not have androgen-like action.
Herba Cynomorii: Herba Cynomorii is the dry meat stem of Cynomoriaceae plant Herba Cynomorii Cynomoriumssongaricum Rupr..Sweet in the mouth, warm in nature.Return spleen, kidney, large intestine channel.But kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.It is soft to be used for waist knee joint flaccidity, sexual impotence spermatorrhea, dryness of the intestine constipation." Amplification on Materia Medica addendum ": (Herba Cynomorii) " nourishing YIN gas is controlled void and constipation due to dry stool usefulness." " detailed outline ": (Herba Cynomorii) " moisturized nourishing muscle and tendon, controlled a little less than the flaccidity." " book on Chinese herbal medicine is original ": (Herba Cynomorii) " nourishing YIN blood deficiency fire, emerging positive controlling nocturnal emission with astringent drugs, reinforcing YIN-essence benefit marrow ".Modern study shows that Herba Cynomorii mainly contains compositions such as volatile oil, aminoacid, triterpenes, also contains steroid class, flavonoid and trace element.Pharmacological research shows that Herba Cynomorii has obvious facilitation, the effect of the free radical of removing is arranged, strengthens resisting oxygen lack humoral immune function, has. antiplatelet aggregative activity.
Fructus Cnidii: Fructus Cnidii is the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cass..Acrid in the mouth, hardship, warm in nature.Return spleen, kidney channel.The Fructus Cnidii warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago, external treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis." detailed outline ": Li Shizhen (1518-1593 A.D.) opinion Fructus Cnidii man woman all suitable " cnidium monnieri is the right kidney gate of vitality, the medicine of few positive three warmers edema caused by disorder of QI, product on legendary god of farming's row are not only assisted the man, and useful married woman." " herbal classic ": (Fructus Cnidii) " swell and ache in housewife people's the moon, the impotence in male pruritus due to damp pathogen removes stagnated QI, sharp joint, epilepsy, malignant boil.Clothes are made light of one's life by commiting suicide for a long time "." not Lu ": (Fructus Cnidii) " warming the middle warmer and descending qi makes the dirty heat of married woman's, and son has been made us in man's postcoital protrusion "." property of medicine opinion ": (Fructus Cnidii) " controls man, woman's void, arthralgia chiefly caused by damp pathogen, malicious wind.Bathe men and women's the moon, go air-cooled, big Yiyang thing "." solar corona ": (Fructus Cnidii) " control cold cruelly, warm husband's yang-energy helps the cloudy gas of woman to pounce on the damage blood stasis, and the waist hip is painful, polyhidrosis around the external genitals exudative dermatitis, extremity insensitive impediment, leucorrhea with red and white discharge, urine reducing "." property of medicine is wanted in the medical center bun ": (Fructus Cnidii) " hard kidney, the profit gate of vitality goes the bottom cold-damp, removes the wind parasite killing ".Modern study shows that the Fructus Cnidii fruit contains volatile oil 1.3%, Coumarins chemical compound (as osthole) and other composition and some trace element.Pharmacological research finds that Fructus Cnidii is influential to reproductive system; To the influence of " yang deficiency " animal, influence the metabolism of cyclic nucleotide and prostaglandin in the body and be one of the mechanism of Fructus Cnidii kidney invigorating and YANG supporting effect or approach, the coumarin composition may be the effective ingredient of Fructus Cnidii kidney invigorating and YANG supporting effect simultaneously; Fructus Cnidii has antiinflammatory and bacteriostatic functions, can suppress pathogenic microorganism and parasite.
Herba Cistanches: Herba Cistanches is the chylocaulous of orobanchaceae plant cistanche.Sweet in the mouth, salty, warm in nature.Return kidney, large intestine channel.The Herba Cistanches kidney-replenishing, benefiting essence-blood, intestine moistening road.Cure mainly the sexual impotence of kidney yang deficiency, asthenia of essence and blood, seminal emission, nebulousurine, the frequent micturition heeltap, the lumbago flaccidity of the lower limbs, tinnitus order flower, menstruation is spread out the phase, infertility, dryness of the intestine constipation." herbal classic ": " main five kinds of strain and seven kinds of impairment, invigorating middle warmer remove stem invasion by pathogenic cold burning pain, support the five internal organs, reinforcing YIN-essence, and beneficial vital essence, how sub, (controlling) married woman
Abdominal mass.Clothes are made light of one's life by commiting suicide for a long time "." not Lu ": " removing the bladder pathogen, (controlling) lumbago, dysentery relieving "." property of medicine opinion ": " beneficial marrow, improving healthy complexion is prolonged life, and controls woman's metrorrhagia, tonifying YANG, big tonification is led red white following "." solar corona ": " it is out of fashion to control the male-sterilisation sun, and the woman is exhausted, and the moon does not produce.Moistening five ZANG-organs, longue meat, warm waist knee joint, the man lets out essence, hematuria is lost drop, leukorrhagia, pain over the perineum ".Modern study shows that the Herba Cistanches chylocaulous contains boschnialoside A, B, C, H.Pharmacological research shows that Herba Cistanches can strengthen low body fluid and the cellular immune function of yang deficiency mice that prednisolone produces; Strengthen monokaryon-macrophage phagocytic ability; Endocrine be can adjust, metabolism and strong effect promoted; Delaying senility function is arranged.
Raw material of the present invention is formed: Fructus Rubi 200～220g, Rhizoma Drynariae 88～94g, Semen Cuscutae 57～63g, Fructus Schisandrae Chinensis 47～52g, Fructus Rosae Laevigatae 38～43g, Herba Epimedii 28～32g, Poria 29～33g, Radix Morindae Officinalis 27～31g, Herba Cynomorii 18～22g, Fructus Cnidii 28～33g, Herba Cistanches 27～33g.
Go up to making the spice of 400～500 capsules, capsular preparation method: after raw material selected, cleans, twice of 70～90% alcohol heating reflux of 7～12 times of amounts of adding, each 0.5～2.5 hour, filter the filtrate concentrate drying, pulverize, granulate after crossing 100 mesh sieves, divide the capsule of packing into, or the adding pharmaceutic adjuvant is pressed into tablet or is distributed into granule.
Its usage and dosage is: each 2, and every day three times.
Raw material of the present invention is formed and can be amplified according to the production scale equal proportion.
The present invention has compared following characteristics with the medicine of existing treatment bony spur pain:
1, curative effect height, effective percentage 95.7%, cure rate 85.9% has made hundreds of patient's rehabilitations through clinical use.
2, reasonable recipe, according to motherland's theory of Chinese medical science, from the essential problem of root solution bony spur pain, through pharmacodynamics test, medicine of the present invention is obvious to the drug effect of animal model.
3, cheap, taking convenience is easy to carry, and has no side effect.
The specific embodiment
By the following examples, in conjunction with results of pharmacodynamic test, further specify the present invention, following embodiment only is used to the present invention is described and to the present invention without limits.
Embodiment 1
Get Fructus Rubi 200g, Rhizoma Drynariae 88g, Semen Cuscutae 57g, Fructus Schisandrae Chinensis 47g, Fructus Rosae Laevigatae 38g, Herba Epimedii 28g, Poria 29g, Radix Morindae Officinalis 27g, Herba Cynomorii 18g, Fructus Cnidii 28g, Herba Cistanches 27g, after selecting, cleaning, twice of 90% alcohol heating reflux of adding 4L, 2 hours for the first time, 0.5 hour for the second time, filter filtrate recycling ethanol, and the vacuum concentration drying, pulverize the 95g Chinese medicine extract.Chinese medicine extract is granulated after crossing 80 mesh sieves, divides the capsule of packing into, every capsules 0.2g that packs into.
Embodiment 2
Get Fructus Rubi 210g, Rhizoma Drynariae 90g, Semen Cuscutae 60g, Fructus Schisandrae Chinensis 50g, Fructus Rosae Laevigatae 40g, Herba Epimedii 30g, Poria 30g, Radix Morindae Officinalis 30g, Herba Cynomorii 20g, Fructus Cnidii 30g, Herba Cistanches 30g, after selecting, cleaning, twice of 80% alcohol heating reflux of adding 6L, 1.5 hours for the first time, 1.5 hours for the second time, filter filtrate recycling ethanol, and the vacuum concentration drying, pulverize the 90g Chinese medicine extract.Chinese medicine extract is granulated after crossing 100 mesh sieves, divides the capsule of packing into, every capsules 0.2g that packs into.
Embodiment 3
Get Fructus Rubi 220g, Rhizoma Drynariae 94g, Semen Cuscutae 63g, Fructus Schisandrae Chinensis 52g, Fructus Rosae Laevigatae 43g, Herba Epimedii 32g, Poria 33g, Radix Morindae Officinalis 31g, Herba Cynomorii 22g, Fructus Cnidii 33g, Herba Cistanches 33g, after selecting, cleaning, twice of 70% alcohol heating reflux of adding 8L, 2.5 hours for the first time, 0.5 hour for the second time, filter filtrate recycling ethanol, and the vacuum concentration drying, pulverize the 106g Chinese medicine extract.Chinese medicine extract is granulated after crossing 120 mesh sieves, divides the capsule of packing into, every capsules 0.2g that packs into.
Embodiment 4
Get Fructus Rubi 220g, Rhizoma Drynariae 94g, Semen Cuscutae 63g, Fructus Schisandrae Chinensis 52g, Fructus Rosae Laevigatae 43g, Herba Epimedii 32g, Poria 33g, Radix Morindae Officinalis 31g, Herba Cynomorii 22g, Fructus Cnidii 33g, Herba Cistanches 33g, after selecting, cleaning, twice of 80% alcohol heating reflux of adding 7L, 1.5 hours for the first time, 1 hour for the second time, filter filtrate recycling ethanol, and the vacuum concentration drying, pulverize the 108g Chinese medicine extract.Chinese medicine extract is granulated after crossing 80 mesh sieves, adds Pulvis Talci 54g, is pressed into tablet, every heavily about 0.2g.
Embodiment 5
Get Fructus Rubi 21og, Rhizoma Drynariae 90g, Semen Cuscutae 60g, Fructus Schisandrae Chinensis 50g, Fructus Rosae Laevigatae 40g, Herba Epimedii 30g, Poria 30g, Radix Morindae Officinalis 30g, Herba Cynomorii 20g, Fructus Cnidii 30g, Herba Cistanches 30g, after selecting, cleaning, twice of 85% alcohol heating reflux of adding 7L, 2.0 hours for the first time, 2.0 hours for the second time, filter filtrate recycling ethanol, and the vacuum concentration drying, pulverize the 93g Chinese medicine extract.Chinese medicine extract is granulated after crossing 100 mesh sieves, adds the 70g microcrystalline Cellulose, is pressed into tablet, every heavily about 0.3g.
Embodiment 6
Get Fructus Rubi 200g, Rhizoma Drynariae 88g, Semen Cuscutae 57g, Fructus Schisandrae Chinensis 47g, Fructus Rosae Laevigatae 38g, Herba Epimedii 28g, Poria 29g, Radix Morindae Officinalis 27g, Herba Cynomorii 18g, Fructus Cnidii 28g, Herba Cistanches 27g, after selecting, cleaning, twice of 90% alcohol heating reflux of adding 5L, 1 hour for the first time, 1 hour for the second time, filter filtrate recycling ethanol, and the vacuum concentration drying, pulverize the 91g Chinese medicine extract.Chinese medicine extract is granulated after crossing 120 mesh sieves, adds 40g microcrystalline Cellulose, 30g starch, 1g magnesium stearate, is pressed into tablet, every heavily about 0.3g.
Embodiment 7
Get Fructus Rubi 200g, Rhizoma Drynariae 88g, Semen Cuscutae 57g, Fructus Schisandrae Chinensis 47g, Fructus Rosae Laevigatae 38g, Herba Epimedii 28g, Poria 29g, Radix Morindae Officinalis 27g, Herba Cynomorii 18g, Fructus Cnidii 28g, Herba Cistanches 27g, after selecting, cleaning, twice of 75% alcohol heating reflux of adding 4.5L, 1.5 hours for the first time, 1.5 hours for the second time, filter filtrate recycling ethanol, and the vacuum concentration drying, pulverize the 94g Chinese medicine extract.Chinese medicine extract is granulated after crossing 100 mesh sieves, adds the 140g cane sugar powder, divides the bag of packing into, every bag of heavily about 1g.
Embodiment 8
Get Fructus Rubi 210g, Rhizoma Drynariae 90g, Semen Cuscutae 60g, Fructus Schisandrae Chinensis 50g, Fructus Rosae Laevigatae 40g, Herba Epimedii 30g, Poria 30g, Radix Morindae Officinalis 30g, Herba Cynomorii 20g, Fructus Cnidii 30g, Herba Cistanches 30g, after selecting, cleaning, twice of 80% alcohol heating reflux of adding 6.5L, 2 hours for the first time, 2 hours for the second time, filter filtrate recycling ethanol, and the vacuum concentration drying, pulverize the 95g Chinese medicine extract.Chinese medicine extract is granulated after crossing 120 mesh sieves, adds 180g cane sugar powder, dextrin 200g, divides the bag of packing into, every bag of heavily about 2g.
Development purpose of the present invention: under the theoretical direction of Chinese medicine " kidney governing bones ", select the Chinese crude drug of kidney-replenishings such as Herba Epimedii, Semen Cuscutae for use, provide new treatment bony spur medicine for clinical.The test of pesticide effectiveness shows that the present invention has antiinflammatory and analgesic activity, and dosage and time-dependent relation are arranged.A kind of compound Chinese patent medicine for the treatment of bone stitch of the present invention claims " twinge gram " again, hereinafter to be referred as " twinge gram ", tests as follows:
The experimental study of twinge gram anti-inflammatory and antalgic drug effect
One, antiinflammatory action:
(1) the rat paw carrageenin causes swollen method:
1, method: adult healthy SD rat 200～300g, male and female half and half, every group 10, divide dosage group (400mg/kg) in solvent control group (o.1%CMC), aspirin 100mg/kg, twinge gram high dose group (800mg/kg), the twinge gram, twinge gram low dose group 200mmg/kg).
2, route of administration: irritate stomach (ig); Administration volume: 4ml/kg.
3, experimental implementation: rat successive administration 5 days, press the sterile working the last time after the administration, injection 1% carrageenin (sterile saline configuration) 0.1ml under the left back sufficient plantar aponeurosis of rat.With the micropipet measurement cause scorching before and cause (per hour once) left and right metapedes volume in scorching back 4 hours, cause with it that value is swelling rate (%) before sufficient volume difference/medicine before and after scorching, relatively be subjected to the significance of reagent group and volume matched group difference.
4, experimental result:
*P＜0.05,
*Compare with the solvent control group p＜0.01
(2) the scorching method of mouse ear caused by dimethylbenzene xylene
1, method: 26～30g male mouse of kunming is divided into 5 groups, 15 every group at random.Experiment divides dosage group (400mg/kg), twinge gram low dose group (200mg/kg) in solvent control group (0.1%CMC), aspirin 100mg/kg, twinge gram high dose group (800mg/kg), the twinge gram.
2, route of administration: irritate stomach (ig); Administration volume: 20ml/kg.
3, experimental implementation: mice successive administration 5 days, after the administration 1 hour the last time, drip in mouse right ear with 100% dimethylbenzene 0.2ml, left ear is done contrast.Behind the 30min dislocation of mice cervical vertebra is caused death, cut two ears, lay the garden auricle at the same position of left and right sides ear respectively, divide torsion balance to weigh, ask left and right sides auricle weight difference with the card punch of diameter 9mm along the auricle baseline, as the swelling degree, comparable group differences significance.
4, experimental result:
*P＜0.05,
*Compare with the solvent control group p＜0.01
Two, analgesic activity:
(1) mice hot plate method:
1, the female kunming mice of method: 26～30g is divided into 5 groups at random, 15 every group.Experiment divides dosage group (400mg/kg), twinge gram low dose group (200mg/kg) in solvent control group (0.1%CMC), morphine (5mg/kg), twinge gram high dose group (800mg/kg), the twinge gram.
2, route of administration: (1) twinge gram: irritate stomach (ig).Administration volume: 20ml/kg.
(2) morphine: lumbar injection (ip).Administration volume: 10ml/kg.
3, experimental implementation:
Mice is placed on 55 ℃ of metallic plates, and with the index of kicking, licking metapedes, jumping and reacting as pain, the threshold of pain stays for testing with interior mice at 30s and uses.
Mice successive administration 5 days, beginning in 1 hour after the administration is the last time measured every Mus threshold of pain every 15min, continuous 2 hours.The significance of comparable group differences.Surpass 60s and represent that analgesic activity is arranged, take out mice immediately.
4, experimental result:
*P＜0.05,
*Compare with the solvent control group p＜0.01
(2) writhing method
1, method: 26～30g male mouse of kunming is divided into 5 groups, 15 every group at random.Experiment divides dosage group (400mg/kg), twinge gram low dose group (200mg/kg) in solvent control group (0.1%CMC), aspirin 100mg/kg, twinge gram high dose group (800mg/kg), the twinge gram.
2, route of administration: irritate stomach (ig); Administration volume: 20ml/kg.
3, experimental implementation: mice successive administration 5 days, beginning in 1 hour after the administration the last time.Mouse peritoneal is injected acetic acid 0.2ml/ of 0.6% fresh configuration, writes down in every Mus 15min and turns round the body number.
4, experimental result:
*P＜0.05,
*Compare with the solvent control group p＜0.01
Three, conclusion (of pressure testing): this test shows that the twinge gram has antiinflammatory and analgesic activity, and dosage and time-dependent relation are arranged.
Claims (5)
1. compound Chinese patent medicine that is used for the treatment of bone stitch is characterized in that the compound Chinese patent medicine agent that it is made by following Chinese crude drug raw material by weight ratio:
Fructus Rubi 200～220, Rhizoma Drynariae 88～94, Semen Cuscutae 57～63, Fructus Schisandrae Chinensis 47～52, Fructus Rosae Laevigatae 38～43, Herba Epimedii 28～32, Poria 29～33, Radix Morindae Officinalis 27～31, Herba Cynomorii 18～22, Fructus Cnidii 28～33, Herba Cistanches 27～33.
2. a kind of compound Chinese patent medicine that is used for the treatment of bone stitch according to claim 1 is characterized in that the compound Chinese patent medicine preparation is tablet or capsule or granule.
3. the described a kind of preparation method that is used for the treatment of the compound Chinese patent medicine of bone stitch of claim 1 is characterized in that: by following weight proportion weighing Chinese crude drug raw material:
Fructus Rubi 200～220, Rhizoma Drynariae 88～94, Semen Cuscutae 57～63, Fructus Schisandrae Chinensis 47～52, Fructus Rosae Laevigatae 38～43, Herba Epimedii 28～32, Poria 29～33, Radix Morindae Officinalis 27～31, Herba Cynomorii 18～22, Fructus Cnidii 28～33, Herba Cistanches 27～33;
After above-mentioned load weighted Chinese crude drug raw material selected, cleans, twice of 70～90% alcohol heating reflux of 7～12 times of amounts of adding, each 0.5～2.5 hour, filter, the filtrate concentrate drying, pulverize Chinese medicine extract, granulate after crossing 80～120 mesh sieves, divide the capsule of packing into, or the adding pharmaceutic adjuvant is pressed into tablet or is distributed into granule.
4. a kind of preparation method that is used for the treatment of the compound Chinese patent medicine of bone stitch according to claim 3 is characterized in that Chinese medicine extract and pharmaceutic adjuvant weight proportion are 1:0.5～4.
5. a kind of preparation method that is used for the treatment of the compound Chinese patent medicine of bone stitch according to claim 3 is characterized in that pharmaceutic adjuvant selects a kind of or mixture in Pulvis Talci, microcrystalline Cellulose, starch, magnesium stearate, cane sugar powder, the dextrin for use.
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