CN105012552A - Traditional Chinese medicine for treating wind-prevailing migratory arthralgia type rheumatic arthritis and preparation method - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating wind-prevailing migratory arthralgia type rheumatic arthritis and a preparation method. The traditional Chinese medicine includes delavay ampelopsis roots, Chinese magnolia, a nude fern herb, white champignons, dinodon rufozonatum, a white chinaure herb, peony, common smoketree, pilose leptodermis leaves, scentedros wood, Korean raspberry roots, a northern maidenhair herb and cymbidium floribundum. The traditional Chinese medicine has the advantages of having the definite curative effect on the wind-prevailing migratory arthralgia type rheumatic arthritis and is small in toxic and side effects.

Description

A kind of Chinese medicine and preparation method for the treatment of domination of wind migratory arthralgia type rheumatic arthritis

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of domination of wind migratory arthralgia type rheumatic arthritis.

Background technology

Rheumatic arthritis is a kind of common acute or chronic ICT.Can recurrent exerbation involve heart.Clinical with joint and muscle migrans miserable, heavily work, pain is for feature.Belong to allergic disease.One of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.

Rheumatic arthritis is the one performance of rheumatic fever.Rheumatic fever is the whole body allergic disease caused by A group beta hemolytic streptococcus infects, and onset of disease has erysipelas etc. to infect medical history often.Rheumatic fever onset is anxious, and is more common in teenager.Rheumatic arthritis can invade heart, causes rheumatic heart disease, and has the performances such as heating, subcutaneous nodule and erythra.

Current western medical treatment rheumatic arthritis there is no good Therapeutic Method, just to ease the pain, symptom management progress is main purpose, clinically also without specific drug, medicine used mostly is nonsteroidal antiinflammatory drug, hormone, slow-acting drug etc., because medicine time is long, toxic and side effects is large, and patient is often difficult to accept.

The rheumatic arthritis book traditional Chinese medical science " arthromyodynia " category, the traditional Chinese medical science thinks that ferritic is weak, space between skin and muscles is not solid, feels wind-cold damp pathogen again, is stranded in meridians, joint.Cause QI-blood circulation smooth, numbness yang channel arteries and veins and produce pain.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of domination of wind migratory arthralgia type rheumatic arthritis, have definite curative effect to domination of wind migratory arthralgia type rheumatic arthritis, toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of domination of wind migratory arthralgia type rheumatic arthritis, its raw medicinal material comprises: Radix Ampelopsis delavayanae, Flos Magnoliae Cocinis, Herba Psiloti Nudi, leopard mushroom, Dinodon rufozonatum (Cantor), Herba Boenninghauseniae Albiflorae, Flos Moutan, Radix seu Folium Heliciae cochinchinensis, Folium Caryophylli, Radix Kadsurae longipedunculatae, Radix rubi coreani, Herba adianti myriosori and NIUJIAOQI.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Ampelopsis delavayanae 10 ~ 20 parts, Flos Magnoliae Cocinis 12 ~ 22 parts, Herba Psiloti Nudi 15 ~ 25 parts, 20 ~ 30 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 10 ~ 20 parts, Herba Boenninghauseniae Albiflorae 15 ~ 25 parts, Flos Moutan 20 ~ 30 parts, Radix seu Folium Heliciae cochinchinensis 20 ~ 30 parts, Folium Caryophylli 10 ~ 20 parts, Radix Kadsurae longipedunculatae 7 ~ 17 parts, Radix rubi coreani 20 ~ 30 parts, Herba adianti myriosori 10 ~ 20 parts and NIUJIAOQI 15 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Ampelopsis delavayanae 10 ~ 15 parts, Flos Magnoliae Cocinis 15 ~ 20 parts, Herba Psiloti Nudi 17 ~ 22 parts, 25 ~ 30 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 13 ~ 18 parts, Herba Boenninghauseniae Albiflorae 17 ~ 22 parts, Flos Moutan 25 ~ 30 parts, Radix seu Folium Heliciae cochinchinensis 23 ~ 28 parts, Folium Caryophylli 15 ~ 20 parts, Radix Kadsurae longipedunculatae 9 ~ 14 parts, Radix rubi coreani 20 ~ 25 parts, Herba adianti myriosori 15 ~ 20 parts and NIUJIAOQI 18 ~ 23 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Ampelopsis delavayanae 15 parts, Flos Magnoliae Cocinis 16 parts, Herba Psiloti Nudi 21 parts, 26 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 17 parts, Herba Boenninghauseniae Albiflorae 18 parts, Flos Moutan 28 parts, Radix seu Folium Heliciae cochinchinensis 24 parts, Folium Caryophylli 18 parts, Radix Kadsurae longipedunculatae 10 parts, Radix rubi coreani 24 parts, Herba adianti myriosori 16 parts and NIUJIAOQI 22 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Ampelopsis delavayanae 12 parts, Flos Magnoliae Cocinis 18 parts, Herba Psiloti Nudi 19 parts, 27 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 15 parts, Herba Boenninghauseniae Albiflorae 20 parts, Flos Moutan 26 parts, Radix seu Folium Heliciae cochinchinensis 25 parts, Folium Caryophylli 16 parts, Radix Kadsurae longipedunculatae 12 parts, Radix rubi coreani 22 parts, Herba adianti myriosori 20 parts and NIUJIAOQI 20 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is ointment, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 45 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 5 ~ 8 times obtained relative to the first step is the ethanol of 75% ~ 85%, and reflux 1 ~ 3 hour, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times more respectively, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to treatment to domination of wind migratory arthralgia type rheumatic arthritis, and toxic and side effects is little.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of domination of wind migratory arthralgia type rheumatic arthritis, its raw medicinal material comprises: Radix Ampelopsis delavayanae, Flos Magnoliae Cocinis, Herba Psiloti Nudi, leopard mushroom, Dinodon rufozonatum (Cantor), Herba Boenninghauseniae Albiflorae, Flos Moutan, Radix seu Folium Heliciae cochinchinensis, Folium Caryophylli, Radix Kadsurae longipedunculatae, Radix rubi coreani, Herba adianti myriosori and NIUJIAOQI.

In above-mentioned Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Radix Ampelopsis delavayanae: [another name] Ramulus et Folium Bischofiae Javanicae is logical, wild Jambul root, five pawl gold, Radix vitis romanetii, Delavay ampelopsis root, Hypoestes poilanei R. Benoistr., Herba Ipomoeae Cairicae, tetrastigma hemsleyanum, red Caulis et Folium cayratiae trifoliae, Radix seu folium Gaultheriae intermediae, fly Caulis Zanthoxyli multijugi, JIANZHONGXIAO, red red Pueraria lobota, red internal diabetes, red Pueraria lobota, black Caulis seu Radix Schisandrae Henryi, SANYE rattan, red Canis familiaris L. poplar.[source] medical material Ji Yuan: be root or the ratan of vitaceae trilobated leaf Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae).[nature and flavor] are pungent; Light; Puckery; Flat.[return through] heart; Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral; Hemostasia and promoting granulation; Removing toxic substances and promoting subsidence of swelling.Main stranguria; Nebulousurine; Hernia; The swelling and hanging down of either of the testes; Rheumatic arthralgia; Traumatic injury congestive edema; Wound hemorrhage; Scald; Carbuncle sore.[extracts] " China's book on Chinese herbal medicine "

Flos Magnoliae Cocinis: [another name] Flos Albiziae, night incense wood blue.[source] medical material Ji Yuan: be the flower of Magnoliacea plant Flos Magnoliae Cocinis.[nature and flavor] are pungent; Warm in nature.[function cures mainly] circulation of qi promoting blood stasis dispelling; Cough-relieving leukorrhagia stopping.Main distending pain over the hypochondrium; Distending pain of the breast; Colicky; Lump in the abdomen; Traumatic injury; Insomnia; Cough and asthma; Leukorrhagia.[extracts] " China's book on Chinese herbal medicine "

Herba Psiloti Nudi: [another name] Folium Pini is blue, iron-stone is loose, ferrum brush handle, Stereocaulon paschale Hoffm., Herba Poae Sphondylodis, bamboo parasitism, Barba Caprae, Herba Sedi Leucocarpi, SHILONG palpus, Herba Lespedezae Cuneatae, rock broom.[source] medical material Ji Yuan: be the herb of Psilotaceae plant Psilotum nudum.[nature and flavor] are sweet; Pungent; Temperature; Nontoxic; Puckery.[return through] heart; Liver; Stomach warp.[function cures mainly] promoting blood circulation and hemostasis; Stimulate the menstrual flow; Expelling wind and removing dampness.Main air pain of dampness syndrome; Women's amenorrhea; Spit blood; Traumatic injury; Rubella.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Leopard mushroom: [another name] Scaly lentinus, white Lentinus Edodes.[source] medical material Ji Yuan: be the sporophore of Bai Mo section fungus leneinus lepideus Franch.[nature and flavor] are sweet; Flat.[return through] heart; Spleen channel.[function cures mainly] fills blood; Benefit conscience.Main insufficiency of vital energy and blood; Deficiency of both the heart and spleen; Fatigue and weak; Insomnia cardiopalmus.[extracts] " China's book on Chinese herbal medicine "

Dinodon rufozonatum (Cantor): [another name] red chain, red company, red chinaberry, red chinaberry Serpentis, fiery red refining, fire white silk Serpentis, erythema Serpentis .[originate] medical material Ji Yuan: be the entirety of Colubridae animal Dinodon rufozonatum (Cantor).Gather and store: autumn in the Summer Solstice catch, catch after kill, dry, burn cloth, grind into powder for subsequent use.Or put into urn after catching, it is hungry 2 right to add a cover, and makes it get rid of feces, then takes out Hai Jing, puts into Sorghum vulgare Pers. Wine or Chinese liquor 2-4 week of leaching, or directly oven dry after cleaning, and grinds into powder.[nature and flavor] sweet in the mouth; Warm in nature.[return through] heart; Spleen channel.[function cures mainly] wind-damp dispelling; Pain relieving; Removing toxic substances sore.Main air wet arthritis; Overall pain; Tuberculous lymphadenitis; Chronic fistula; Ulcer; Scabies.[extracts] " China's book on Chinese herbal medicine "

Herba Boenninghauseniae Albiflorae: [another name] Boenninghausenia albiflora, Song Fengcao, stone Fructus Piperis, smelly sand, orangutan rust Herba rutae, Herba rutae, bitter Dendrobium denneanum Kerr., large Solanum lasiocarpum, She Pancao, scald grass, lead to that flower, Periostracum Serpentis are careless, goatweed, copper foot Herba Achilleae, nine N of two Herba Saxifragae, No. two xanthate.[source] medical material Ji Yuan: be the herb of dicotyledon medicine rutaceae Boenninghausenia albiflora.[nature and flavor] are pungent; Bitter; Cool in nature.[return through] lung; Liver; Spleen channel.[function cures mainly] induces sweat; Preventing the attack (or recurrence) of malaria; Invigorate blood circulation; Removing toxic substances.Main cold, fever; Bronchitis; Malaria; Gastroenteritis; Traumatic injury; Carbuncle skin ulcer swells; Scald.[extracts] " China's book on Chinese herbal medicine "

Flos Moutan: [source] medical material Ji Yuan: be the flower of Paeoniaceae plant Paeonia suffruticosa Paeonia suffruticosaAndr..[nature and flavor] are bitter; Light; Flat.[return through] Liver Channel.[function cures mainly] promoting blood flow to regulate menstruation.Main menoxenia; Abdominal pain during menstruation.[extracts] " China's book on Chinese herbal medicine "

Radix seu Folium Heliciae cochinchinensis: [another name] Weng Zaishu, fall dragsaw, the ten thousand dozens of rods, sheep miaow dung, Chinese olive tree, the young dung of sheep.[source] medical material Ji Yuan: be root or the leaf of Proteaceae plant fruitlet Eumeces Chinensis eye.[nature and flavor] are pungent; Bitter; Cool in nature.[function cures mainly] wind-expelling pain-stopping; Promoting blood circulation and detumescence; Astringing to arrest bleeding.Main rheumatic ostalgia; Traumatic injury congestive edema; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Folium Caryophylli: [another name] Folium Photiniae (Folium Photiniae serrulatae), Flos syringae persicae, Pedicellus Melo, Folium Caryophylli.[source] medical material Ji Yuan: be the leaf of dicotyledon medicine Maguireothamnus speciosus hair Flos syringae persicae.[nature and flavor] are bitter; Flat.[return through] lung meridian.[function cures mainly] expelling wind and removing dampness; Pain relieving.Main headache; Rheumatic arthralgia; Lumbago.[extracts] " China's book on Chinese herbal medicine "

Radix Kadsurae longipedunculatae: [another name] Cortex tripterygii hypoglauci radicis, Jin Guxiang, tight bone are fragrant, cured, the wide good fortune rattan of wood, interior emaciation due to emotional upset, cold meal bag, DAHUOXUE, Radix seu Caulis Schisandrae Sinensis, Radix Campylotropis Hirtella (Herba Myrsines Africanae), interiorly redly to disappear, bradawl, Radix Morindae Officinalis, Ramulus et Folium Mussaendae Pubescentis, Fissistigma bracteolatum Chatt. root, Cortex Ampelopsis Aconitifoliae Radicis.[source] medical material Ji Yuan: be root or the root bark of Schisandraceae Plant Kadsura Longepedunculata.[nature and flavor] are pungent; Bitter; Warm in nature.[return through] spleen; Stomach; Liver Channel.[function cures mainly] regulating QI to relieve pain; Dispelling wind and removing obstruction in the collateral; Promoting blood circulation and detumescence.Main stomachache; Stomachache; Rheumatic arthralgia; Dysmenorrhea; Menoxenia; Puerperal abdonimal pain; Laryngopharynx swelling and pain; Hemorrhoid; Innominate toxic swelling; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix rubi coreani: [another name] Radix Rubi Setchuenensis.[source] medical material Ji Yuan: be the root of rosaceous plant rubus coreanus.Latin plant animal mineral name: Rubus coreanus Miq.[nature and flavor] are pained; Flat; Nontoxic.[return through] liver; Kidney channel.[function cures mainly] promoting blood circulation and hemostasis, expelling wind and removing dampness.Main traumatic injury, fracture, menoxenia, spits blood, epistaxis, rheumatic arthralgia, edema, dysuria, scrofula.[extracts] " China's book on Chinese herbal medicine "

Herba adianti myriosori: [another name] iron Pilus Sus domestica seven, Herba Adianti Flabellulati, thin Herba pteridii latiusculi beanstalk, Herba pteridii latiusculi beanstalk lotus.[source] medical material Ji Yuan: be the herb of adiantaceae plant ass back iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb..[nature and flavor] put down; Light hardship.[return through] urinary bladder channel.[function cures mainly] heat clearing away; Diuretic; Invigorate blood circulation.Main burn and scald; Traumatic injury; Uroschesis; Chilblain.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

NIUJIAOQI: [another name] black Rhizoma Et Radix Notopterygii, meat slender acanthopanax, snow Radix Angelicae Sinensis, Lijing Radix Angelicae Gigatis.[source] medical material Ji Yuan: be the root of Araliaceae Radix Araliae apioidis.[nature and flavor] bitter in the mouth; Pungent; Slightly warm in nature.[function cures mainly] expelling wind and removing dampness; Promoting blood circulation and detumescence.Main air pain of dampness syndrome; Traumatic injury; Fracture; Stomachache; Lumbago; Lymphadenitis.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Ampelopsis delavayanae 10 ~ 20 parts, Flos Magnoliae Cocinis 12 ~ 22 parts, Herba Psiloti Nudi 15 ~ 25 parts, 20 ~ 30 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 10 ~ 20 parts, Herba Boenninghauseniae Albiflorae 15 ~ 25 parts, Flos Moutan 20 ~ 30 parts, Radix seu Folium Heliciae cochinchinensis 20 ~ 30 parts, Folium Caryophylli 10 ~ 20 parts, Radix Kadsurae longipedunculatae 7 ~ 17 parts, Radix rubi coreani 20 ~ 30 parts, Herba adianti myriosori 10 ~ 20 parts and NIUJIAOQI 15 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Ampelopsis delavayanae 10 ~ 15 parts, Flos Magnoliae Cocinis 15 ~ 20 parts, Herba Psiloti Nudi 17 ~ 22 parts, 25 ~ 30 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 13 ~ 18 parts, Herba Boenninghauseniae Albiflorae 17 ~ 22 parts, Flos Moutan 25 ~ 30 parts, Radix seu Folium Heliciae cochinchinensis 23 ~ 28 parts, Folium Caryophylli 15 ~ 20 parts, Radix Kadsurae longipedunculatae 9 ~ 14 parts, Radix rubi coreani 20 ~ 25 parts, Herba adianti myriosori 15 ~ 20 parts and NIUJIAOQI 18 ~ 23 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Ampelopsis delavayanae 15 parts, Flos Magnoliae Cocinis 16 parts, Herba Psiloti Nudi 21 parts, 26 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 17 parts, Herba Boenninghauseniae Albiflorae 18 parts, Flos Moutan 28 parts, Radix seu Folium Heliciae cochinchinensis 24 parts, Folium Caryophylli 18 parts, Radix Kadsurae longipedunculatae 10 parts, Radix rubi coreani 24 parts, Herba adianti myriosori 16 parts and NIUJIAOQI 22 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Ampelopsis delavayanae 12 parts, Flos Magnoliae Cocinis 18 parts, Herba Psiloti Nudi 19 parts, 27 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 15 parts, Herba Boenninghauseniae Albiflorae 20 parts, Flos Moutan 26 parts, Radix seu Folium Heliciae cochinchinensis 25 parts, Folium Caryophylli 16 parts, Radix Kadsurae longipedunculatae 12 parts, Radix rubi coreani 22 parts, Herba adianti myriosori 20 parts and NIUJIAOQI 20 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is ointment, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 45 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 5 ~ 8 times obtained relative to the first step is the ethanol of 75% ~ 85%, and reflux 1 ~ 3 hour, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times more respectively, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1 ointment

Get Radix Ampelopsis delavayanae 120g, Flos Magnoliae Cocinis 180g, Herba Psiloti Nudi 190g, leopard mushroom 270g, Dinodon rufozonatum (Cantor) 150g, Herba Boenninghauseniae Albiflorae 200g, Flos Moutan 260g, Radix seu Folium Heliciae cochinchinensis 250g, Folium Caryophylli 160g, Radix Kadsurae longipedunculatae 120g, Radix rubi coreani 220g, Herba adianti myriosori 200g and NIUJIAOQI 200g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 50 object powder, and adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 200 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.

Embodiment 2 capsule

Get Radix Ampelopsis delavayanae 150g, Flos Magnoliae Cocinis 160g, Herba Psiloti Nudi 210g, leopard mushroom 260g, Dinodon rufozonatum (Cantor) 170g, Herba Boenninghauseniae Albiflorae 180g, Flos Moutan 280g, Radix seu Folium Heliciae cochinchinensis 240g, Folium Caryophylli 180g, Radix Kadsurae longipedunculatae 100g, Radix rubi coreani 240g, Herba adianti myriosori 160g and NIUJIAOQI 220g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 45 minutes, be ground into smalls, be screened into 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 6 times obtained relative to the first step is the ethanol of 85%, and reflux 3 hours, extracts 2 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 6 times more respectively, each decoction 3 hours, decoct 2 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 325 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Excipient is carboxymethyl starch, and its weight content in capsule is 25%;

Disintegrating agent is hydroxypropyl cellulose, and its weight content in capsule is 12%;

Fluidizer is magnesium stearate, and its weight content in capsule is 2.5%.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 2, (concentration is 8.82g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 44.1 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>44.1 crude drug/kg of the present invention, every day, maximum dosage-feeding was 88.2 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.147g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine of the present invention is 600 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: the capsule of Chinese medicine embodiment 2 of the present invention presses 15.78,23.45 and 45.11g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 90 routine cases are my Out-patient Department patient of in July, 2012 ~ 2014 year June.Be divided into treatment group and matched group at random, wherein treatment group 45 people, male 28 people, women 17 people, 20 ~ 63 years old age, the course of disease 5 months ~ 6 years 3 months; Matched group 45 people, male 26 people, women 19 people, 21 ~ 65 years old age, the course of disease 6 months ~ 6 years 6 months.Two groups in age, sex, clinical manifestation etc. through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria: the standard formulated according to the academic conference of Society of Internal Medicine of Chinese Medical Association Second National rheumatism: 1, have hemolytic streptococcal infection history before disease more; 2, extremities joint wandering pain or swell and ache; 3, affected joints red and swollen heat pain, movable function is limited, and some cases can have low grade fever concurrently, erythema nodosum or erythema iris, cardiopulmonary pathological changes etc.; 4, lab testing: active stage erythrocyte sedimentation rate speed, how normal nonmobile phase is; 5, x-ray inspection: the rarely seen soft tissue swelling of affected joints, without bone lesion.

Syndrome Differentiation of Traditional Chinese Medicine standard: domination of wind migratory arthralgia: joint aches, migration is indefinite, joint stuffiness, or has aversion to wind and cold to generate heat, thin fur, floating pulse.

Therapeutic Method:

Treatment group: take the embodiment of the present invention 2 capsule, every day 3 times, each 54 weeks is a course for the treatment of.

Matched group: oral western medicine ibuprofen 0.3g/ time, every day 3 times 4 weeks is a course for the treatment of.

Curative effect judging standard: 1, clinical recovery: affected joints swells and ache disappearance, joint movement function recovers normal, and erythrocyte sedimentation rate and anti-" O " recover normal; 2, effective: affected joints swells and ache and is clearly better, movable joint recovers normal substantially, and erythrocyte sedimentation rate and anti-" O " obviously decline; 3, effective: swelling and ache of affected joints is improved, affected joints movable violent after also some swells and ache, erythrocyte sedimentation rate and anti-" O " decline; 4, invalid: after two courses for the treatment of of taking medicine, affected joints swells and ache without obviously alleviating, and movable function is still limited, erythrocyte sedimentation rate is unchanged with anti-" O ".

Therapeutic outcome: after treating a course for the treatment of, statistical result sees the following form.

Group	n	Clinical recovery	Effective	Effectively	Invalid	Effectively total
							Treatment group	45	12	18	12	3	42(93.3％)
Matched group	45	3	15	19	8	37(82.2％)

Concrete case: Zhang, female, 59 years old, the right gonalgia of patient, meet cold increasing the weight of, joint stuffiness 5 years, nearly 1 month exacerbation of symptoms, right knee joint swelling was obvious, and multi-treatment is invalid.Examine as rheumatic arthritis.According to clinical symptoms: joint aches, migration is indefinite, joint stuffiness, aversion to wind and cold, thin fur, floating pulse, and typing is domination of wind migratory arthralgia type rheumatic arthritis.Take Chinese medicine embodiment 2 capsule of the present invention, every day 3 times, each 5, after 5 days, local swelling disappears substantially, can leave the bed after 15 days walking, joint movement function recovers normal substantially, and after 4 weeks, activity freely, erythrocyte sedimentation rate and anti-" O " recover normal, and clinical cure, follows up a case by regular visits to and have no recurrence in 1 year.

Claims (9)

1. treat a Chinese medicine for domination of wind migratory arthralgia type rheumatic arthritis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Radix Ampelopsis delavayanae, Flos Magnoliae Cocinis, Herba Psiloti Nudi, leopard mushroom, Dinodon rufozonatum (Cantor), Herba Boenninghauseniae Albiflorae, Flos Moutan, Radix seu Folium Heliciae cochinchinensis, Folium Caryophylli, Radix Kadsurae longipedunculatae, Radix rubi coreani, Herba adianti myriosori and NIUJIAOQI.

2. Chinese medicine as claimed in claim 1, is characterized in that, the following Radix Ampelopsis delavayanae of ratio of weight and number 10 ~ 20 parts of each raw medicinal material of described Chinese medicine, Flos Magnoliae Cocinis 12 ~ 22 parts, Herba Psiloti Nudi 15 ~ 25 parts, 20 ~ 30 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 10 ~ 20 parts, Herba Boenninghauseniae Albiflorae 15 ~ 25 parts, Flos Moutan 20 ~ 30 parts, Radix seu Folium Heliciae cochinchinensis 20 ~ 30 parts, Folium Caryophylli 10 ~ 20 parts, Radix Kadsurae longipedunculatae 7 ~ 17 parts, Radix rubi coreani 20 ~ 30 parts, Herba adianti myriosori 10 ~ 20 parts and NIUJIAOQI 15 ~ 25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Ampelopsis delavayanae 10 ~ 15 parts, Flos Magnoliae Cocinis 15 ~ 20 parts, Herba Psiloti Nudi 17 ~ 22 parts, 25 ~ 30 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 13 ~ 18 parts, Herba Boenninghauseniae Albiflorae 17 ~ 22 parts, Flos Moutan 25 ~ 30 parts, Radix seu Folium Heliciae cochinchinensis 23 ~ 28 parts, Folium Caryophylli 15 ~ 20 parts, Radix Kadsurae longipedunculatae 9 ~ 14 parts, Radix rubi coreani 20 ~ 25 parts, Herba adianti myriosori 15 ~ 20 parts and NIUJIAOQI 18 ~ 23 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Ampelopsis delavayanae 15 parts, Flos Magnoliae Cocinis 16 parts, Herba Psiloti Nudi 21 parts, 26 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 17 parts, Herba Boenninghauseniae Albiflorae 18 parts, Flos Moutan 28 parts, Radix seu Folium Heliciae cochinchinensis 24 parts, Folium Caryophylli 18 parts, Radix Kadsurae longipedunculatae 10 parts, Radix rubi coreani 24 parts, Herba adianti myriosori 16 parts and NIUJIAOQI 22 parts.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Ampelopsis delavayanae 12 parts, Flos Magnoliae Cocinis 18 parts, Herba Psiloti Nudi 19 parts, 27 parts, leopard mushroom, Dinodon rufozonatum (Cantor) 15 parts, Herba Boenninghauseniae Albiflorae 20 parts, Flos Moutan 26 parts, Radix seu Folium Heliciae cochinchinensis 25 parts, Folium Caryophylli 16 parts, Radix Kadsurae longipedunculatae 12 parts, Radix rubi coreani 22 parts, Herba adianti myriosori 20 parts and NIUJIAOQI 20 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is ointment, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 45 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 5 ~ 8 times obtained relative to the first step is the ethanol of 75% ~ 85%, and reflux 1 ~ 3 hour, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times more respectively, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is ointment, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;

Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;

3rd step, joins the Chinese medicinal powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 45 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 5 ~ 8 times obtained relative to the first step is the ethanol of 75% ~ 85%, and reflux 1 ~ 3 hour, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times more respectively, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.