CN105663434A - Traditional Chinese medicine for treating allergic cutaneous vasculitis and preparation method - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating allergic cutaneous vasculitis and a preparation method. The traditional Chinese medicine comprises the following raw medicine materials: polygonum filiforme, dindygulen peperomia herb, Indian skullcap herb with root, endive, physalis angulata, polygonum orientale root, diplospora dubia, threeleaf loosestrife herb, unilocular crateva root, passiflora papilio, acanthopanax trifoliatus branches and leaves, bast willow root, faber meadowrue root and rhizome and ophiorrhiza japonica. The traditional Chinese medicine provided by the invention has the beneficial effects of exact curative effect, no toxic or side effect and no adverse reaction when used for treating allergic cutaneous vasculitis by matching with a western medical conventional method.

Description

A kind of Chinese medicine treating allergic cutaneous vasculitis and preparation method

Technical field

The present invention relates to containing the medicinal preparation deriving from plant, animal or mineral component, particularly relate to a kind of Chinese medicine treating allergic cutaneous vasculitis and preparation method.

Background technology

Allergic cutaneous vasculitis (allergiccutaneousvasculitis) is also known as allergic vasculitis (allergicvasculitis), systemic allergic vasculitis (systemicallergicvasculitis), nodositas skin allergid (nodulardermalallergidi). It it is the gangrenous inflammation of dermal capillary and capillary vessel. Being more common in adolescence, primary disease premorbid often has acute bacterial or virus infection history in 1～2 week. Most of patients is skin involvement only, and minority can involve internal organs.

Skin lesion onset be foxtail millet grain to Semen phaseoli radiati large red maculopapule and purpura, cumulative greatly, become vesicle or blood blister, it is possible to for kermesinus tuberosity, ulcer, overlying drying property blood crusts after tuberosity necrosis, can be formed. Atrophic scar is often left after ulcer healing. Multiple infringement often exists simultaneously, but with purpura, tuberosity, necrosis and ulcer for feature. Erythra is apt to occur in shank, ankle and upper limb etc., is symmetric, it is possible to involve trunk. Conscious pain or burn feeling. Some patients can accompany internal organs to get involved, and such as kidney, gastrointestinal, nervous system etc., is called allergic skin-systemic vasculitis.

Primary disease pathogenic factors is more and complicated, it is considered that cause mainly due to medicine and infection, and modal causative agents has group of barbiturates, phenothiazines, sulfonamides, penicillin, iodides, aspirin and foreign protein etc. Infecting also is a key factor, such as virus, streptococcus, tubercule bacillus, leprosy bacillus etc. Fungus and protozoon are believed to be a kind of paathogenic factor. Insecticides (tech) & Herbicides (tech) and petroleum product are also relevant with primary disease. In addition having the disease of inwardness, such as frozen egg leukemia, hyperglobulinemia, systemic lupus erythematosus (sle), rheumatoid arthritis etc. also can cause primary disease. The state of an illness can recurrent exerbation several months or several years. Doctor trained in Western medicine hormone therapy side effect is more apparent, and relapse rate is high, and dosage is difficult to control to, unsuitable prolonged application.

Summary of the invention

The technical problem to be solved is in that, it is provided that a kind of determined curative effect and the Chinese medicine for the treatment of allergic cutaneous vasculitis having no side effect and preparation method.

In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine treating allergic cutaneous vasculitis, its raw medicinal material includes: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Herba Peperomiae Dindygulensis, Herba Scutellariae indicae, Herba Sonchi Arvensis, hardship, Herba Polygoni Orientalis root, Radix Tricalysiae dubiae, Herba Lysimachiae Insignis, Radix Crataevae Unilocularis, butterfly rattan, white branch and leaf, Radix pterocaryae stenopterae, Radix et Rhizoma Thalictri Faberi and Herba ophiorrhizae japonicae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10～20 parts, Herba Peperomiae Dindygulensis 5～15 parts, Herba Scutellariae indicae 5～15 parts, Herba Sonchi Arvensis 30～40 parts, bitter 45～55 parts, Herba Polygoni Orientalis root 25～35 parts, Radix Tricalysiae dubiae 5～15 parts, Herba Lysimachiae Insignis 45～55 parts, Radix Crataevae Unilocularis 10～20 parts, 20～30 parts of butterfly rattan, 10～20 parts of white branch and leaf, Radix pterocaryae stenopterae 20～30 parts, Radix et Rhizoma Thalictri Faberi 55～65 parts and Herba ophiorrhizae japonicae 30～40 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10～15 parts, Herba Peperomiae Dindygulensis 5～10 parts, Herba Scutellariae indicae 5～10 parts, Herba Sonchi Arvensis 30～35 parts, bitter 45～50 parts, Herba Polygoni Orientalis root 25～30 parts, Radix Tricalysiae dubiae 5～10 parts, Herba Lysimachiae Insignis 45～50 parts, Radix Crataevae Unilocularis 10～15 parts, 20～25 parts of butterfly rattan, 10～15 parts of white branch and leaf, Radix pterocaryae stenopterae 20～25 parts, Radix et Rhizoma Thalictri Faberi 55～60 parts and Herba ophiorrhizae japonicae 30～35 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 11 parts, Herba Peperomiae Dindygulensis 6 parts, Herba Scutellariae indicae 8 parts, Herba Sonchi Arvensis 32 parts, bitter 49 parts, Herba Polygoni Orientalis root 26 parts, Radix Tricalysiae dubiae 7 parts, Herba Lysimachiae Insignis 46 parts, Radix Crataevae Unilocularis 14 parts, 22 parts of butterfly rattan, 13 parts of white branch and leaf, Radix pterocaryae stenopterae 24 parts, Radix et Rhizoma Thalictri Faberi 58 parts and Herba ophiorrhizae japonicae 34 parts.

The preparation method that present invention also offers above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine composition raw medicinal material, adds the ethanol that determining alcohol is 80～90% relative to mixture quality 3～5 times, is heated to reflux 40～60 minutes, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to medicinal residues quality 2～3 times, be heated to reflux 30～50 minutes, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes and sieves the micropowders of acquisition 100～200 order;

3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3～0.5 times, the starch of 0.3～0.5 times, the magnesium stearate of 0.005～0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is loaded in capsule housing, namely obtains capsule finished product.

The preparation method that present invention also offers above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 70～80% relative to 4～6 times of mixture, heat to boiling reflux 2～3 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 70～80 DEG C subsequently under vacuum 0.01～0.05Mpa is the mastic of 1.03～1.05, spray drying, the inlet temperature of spray dryer 165～185 DEG C, leaving air temp 65～85 DEG C, it is ground into powder subsequently, makes dried cream powder;

Second step: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.4～0.6 times and 0.4～0.6 times in the dried cream powder obtained, make granule, dries in 65～75 DEG C, it is thus achieved that granule.

Beneficial effects of the present invention: Chinese medicine of the present invention coordinates doctor trained in Western medicine conventional treatment allergic cutaneous vasculitis to have definite curative effect, has no side effect and untoward reaction.

Detailed description of the invention

The invention provides a kind of Chinese medicine treating allergic cutaneous vasculitis, its raw medicinal material includes: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Herba Peperomiae Dindygulensis, Herba Scutellariae indicae, Herba Sonchi Arvensis, hardship, Herba Polygoni Orientalis root, Radix Tricalysiae dubiae, Herba Lysimachiae Insignis, Radix Crataevae Unilocularis, butterfly rattan, white branch and leaf, Radix pterocaryae stenopterae, Radix et Rhizoma Thalictri Faberi and Herba ophiorrhizae japonicae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis): [source] is the herb of polygonaceae plant Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), undercoat Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis). [nature and flavor] are pungent, bitter, cool in nature. [function cures mainly] cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain. Main hemoptysis, spit blood, have blood in stool, metrorrhagia, have loose bowels, dysentery, stomachache, abdominal pain in menstruation, puerperal abdominal pain due to blood stasis, traumatic injury, rheumatic arthralgia, scrofula, carbuncle.

Herba Peperomiae Dindygulensis: [source] is the herb of Piperaceae plant Herba Peperomiae Dindygulensis. [nature and flavor] are pungent, cool. [return through] returns lung, spleen, liver, kidney channel. [function cures mainly] heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, inducing diuresis to remove edema. Main lung-heat cough with asthma, measles, sore, cancerous protuberance, burn and scald, traumatic injury, oedema due to nephritis.

Herba Scutellariae indicae: [source] is the herb of labiate Herba Scutellariae indicae. [nature and flavor] acrid in the mouth, bitter, cold in nature. [return through] GUIXIN, liver, lung meridian. [function cures mainly] heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, hemostasia and detumescence. Main carbuncle furunculosis, lung abscess, acute appendicitis, scrofula, venom, lung-heat cough with asthma, toothache, laryngalgia, pharyngalgia, bones and muscles pain, spit blood, spitting of blood, have blood in stool, traumatic injury, wound hemorrhage, skin pruritus.

Herba Sonchi Arvensis: [source] is the herb of feverfew Herba Sonchi Arvensis. [nature and flavor] bitter in the mouth, cold in nature. [function cures mainly] heat-clearing and toxic substances removing, promoting diuresis and pus discharge, cooling blood for hemostasis. Main laryngopharynx swelling and pain, furuncle toxic swelling, hemorrhoid, acute bacillary dysentery, enteritis, lung abscess, acute appendicitis, epistaxis, spitting of blood, hematuria, have blood in stool, metrorrhagia.

Bitter: [another name], Calyx seu fructus physalis yellow, careless, little, Fructus Seu Herba Pubescentis, Herba Clerodendri fortunati, Herba seu Fructus Physalis Minimae, firecracker grass, to split bat grass, Herba Crotalariae Ferrugineae, loud lake. [source] medical material Ji Yuan: for the herb that plant of Solanaceae is bitter. Gather and store: adopting herb in summer, autumn, using fresh herb or dry. [nature and flavor] bitter in the mouth; Acid; Cold in nature. [function cures mainly] heat clearing away; Diuresis; Removing toxic substances; Detumescence. Main flu; Cough due to lung-heat; Laryngopharynx swelling and pain; Gingival swelling and pain; Jaundice due to damp-heat; Dysentery; Edema; Pyretic stranguria; Pemphigus; Furuncle. [each discussion] 1. " Jiangxi traditional herbal medicine ": control a day skin ulcer, infection with swollen head, furuncle of finger, gingival swelling and pain, jaundice due to damp-heat, red swelling and pain of throat, cough due to lung-heat, pyretic stranguria. 2. " Chinese herbal medicine is commonly used in Shanghai ": heat-clearing and toxic substances removing, diuresis is stopped blooding, dispersing swelling and dissipating binds. Control laryngopharynx swelling and pain, lung abscess, parotitis; Dysuria, hematuria. Gingival swelling and pain, pemphigus.

Herba Polygoni Orientalis root: [another name] Herba Polygoni Orientalis root, smartweed root. [source] medical material Ji Yuan: for the rhizome of polygonaceae plant Polygonum knotweed. Gather and store: summer, autumn take root, cleaning, dry or using fresh herb. [nature and flavor] are pungent; Cool in nature. [function cures mainly] heat-clearing and toxic substances removing; Eliminating dampness and dredging channels; Promoting tissue regeneration and ulcer healing. Main dysentery; Intestinal is scorching; Edema; Foot gas; Rheumatic arthralgia; Traumatic injury; Urticaria; Sore, carbuncle and painful swelling or of a specified duration bursting are not held back.

Radix Tricalysiae dubiae: [source] is the root of Maguireothamnus speciosus Radix Tricalysiae dubiae. [nature and flavor] are bitter, cool. [return through] returns Liver Channel. [function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds. Main scrofula, backache, head furuncle, treating swelling and pain by traumatic injury.

Herba Lysimachiae Insignis: herb that [source] is Ofthe Primulaceae SANYE Rhizoma et radix valerianae or root. [nature and flavor] are pungent, bitter, warm in nature. [function cures mainly] dispelling wind and removing obstruction in the collateral, promoting flow of QI and blood. Main air pain of dampness syndrome, coldness and pain in the epigastrium, treating swelling and pain by traumatic injury.

Radix Crataevae Unilocularis: [source] comes from " choosing of Simao, Yunnan Chinese herbal medicine ". [source] medical material Ji Yuan: for root or the bark of Capparidaceae tree head dish. Gather and store: autumn gathers, using fresh herb or dry. [nature and flavor] bitter in the mouth; Cold in nature. [function cures mainly] heat-clearing and toxic substances removing; Damp eliminating is active; Pain relieving. Main hepatitis; Dysentery; Diarrhoea; Lithangiuria; Tonsillitis; Rheumatic arthritis; Stomachache.

Butterfly rattan: [another name] floral leaf butterfly rattan, Herba Christiae leaf careless, half of. [source] medical material Ji Yuan: for the herb of Passifloraceae plant gold foxtail millet rattan. Gather and store: autumn takes Herb, cleaning, cutting, dry. [nature and flavor] bitter in the mouth; Sweet; Property is put down. [function cures mainly] promoting blood circulation and hemostasis; Damp-clearing pain-relieving; Heat-clearing and toxic substances removing. Main haematemesis; Have blood in stool; Puerperal hemorrhage is more than; Dysfunctional uterine hemorrhage; Stomachache; Rheumatic arthritis and venom.

Bai Zhiye: [another name] Bai Ciye, Bai Leyuan. [source] medical material Ji Yuan: for the browse that Araliaceae is white. Gather and store: the whole year all can adopt, using fresh herb or dry. [nature and flavor] bitter in the mouth; Pungent; Cold nature. [function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and detumescence; Dehumidifying sore. Main cold, fever; Cough chest pain; Dysentery; Rheumatic arthralgia; Traumatic injury; Fracture; Knife injury; Ulcerative carbuncle furuncle furuncle; Aphtha; Eczema; Scabies; Insect-bite.

Radix pterocaryae stenopterae: [another name] Pterocarya Stenoptera root. [source] comes from " classifying herbal ". [source] medical material Ji Yuan: for root or the root bark of juglandaceae plant Pterocarya Stenoptera. Gather and store: the whole year all can excavate or excavate in conjunction with lumbering, and elimination is gone earth, cleaning, dry, or when taking advantage of fresh, strip root bark, dry. [nature and flavor] are bitter; Pungent; Hot in nature. [return through] lung; Liver Channel. [function cures mainly] wind-expelling pain-stopping; Killing parasites for relieving itching; Removing toxic substances sore. Main air pain of dampness syndrome; Toothache; Scabies; Sore swollen toxin; With the passing of time ulcer do not hold back; The burning hot wound of soup; Cough.

Radix et Rhizoma Thalictri Faberi: [source] be ranunculaceae plant great Ye Thalictrum aquilegifolium L. var. sibiricum Regel, the rhizome of point leaf Thalictrum aquilegifolium L. var. sibiricum Regel and East China Thalictrum aquilegifolium L. var. sibiricum Regel and root. [nature and flavor] bitter in the mouth, cold in nature. [return through] returns large intestine, Liver Channel. [function cures mainly] heat clearing away, pathogenic fire purging, removing toxic substances. Main dysentery, diarrhoea, conjunctival congestion and swelling pain, jaundice due to damp-heat.

Herba ophiorrhizae japonicae: [source] is the herb of Maguireothamnus speciosus Herba ophiorrhizae japonicae. [nature and flavor] put down, light. [return through] returns Liver Channel. [function cures mainly] expelling phlegm for arresting cough, promoting blood flow to regulate menstruation. Main cough, over-strained hemoptysis, hematochezia of defecating, dysmenorrhes, menoxenia, bones and muscles pain, bruise.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10～20 parts, Herba Peperomiae Dindygulensis 5～15 parts, Herba Scutellariae indicae 5～15 parts, Herba Sonchi Arvensis 30～40 parts, bitter 45～55 parts, Herba Polygoni Orientalis root 25～35 parts, Radix Tricalysiae dubiae 5～15 parts, Herba Lysimachiae Insignis 45～55 parts, Radix Crataevae Unilocularis 10～20 parts, 20～30 parts of butterfly rattan, 10～20 parts of white branch and leaf, Radix pterocaryae stenopterae 20～30 parts, Radix et Rhizoma Thalictri Faberi 55～65 parts and Herba ophiorrhizae japonicae 30～40 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10～15 parts, Herba Peperomiae Dindygulensis 5～10 parts, Herba Scutellariae indicae 5～10 parts, Herba Sonchi Arvensis 30～35 parts, bitter 45～50 parts, Herba Polygoni Orientalis root 25～30 parts, Radix Tricalysiae dubiae 5～10 parts, Herba Lysimachiae Insignis 45～50 parts, Radix Crataevae Unilocularis 10～15 parts, 20～25 parts of butterfly rattan, 10～15 parts of white branch and leaf, Radix pterocaryae stenopterae 20～25 parts, Radix et Rhizoma Thalictri Faberi 55～60 parts and Herba ophiorrhizae japonicae 30～35 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 11 parts, Herba Peperomiae Dindygulensis 6 parts, Herba Scutellariae indicae 8 parts, Herba Sonchi Arvensis 32 parts, bitter 49 parts, Herba Polygoni Orientalis root 26 parts, Radix Tricalysiae dubiae 7 parts, Herba Lysimachiae Insignis 46 parts, Radix Crataevae Unilocularis 14 parts, 22 parts of butterfly rattan, 13 parts of white branch and leaf, Radix pterocaryae stenopterae 24 parts, Radix et Rhizoma Thalictri Faberi 58 parts and Herba ophiorrhizae japonicae 34 parts.

The preparation method that present invention also offers above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine composition raw medicinal material, adds the ethanol that determining alcohol is 80～90% relative to mixture quality 3～5 times, is heated to reflux 40～60 minutes, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to medicinal residues quality 2～3 times, be heated to reflux 30～50 minutes, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes and sieves the micropowders of acquisition 100～200 order;

3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3～0.5 times, the starch of 0.3～0.5 times, the magnesium stearate of 0.005～0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is loaded in capsule housing, namely obtains capsule finished product.

The preparation method that present invention also offers above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 70% relative to 4 times of mixture, heat to boiling reflux 2 hours, filter, adopt percolation with per minute 1 speed slowly percolation, collect percolate, being evaporated to relative density when 80 DEG C subsequently under vacuum 0.03Mpa is the mastic of 1.03, spray drying, the inlet temperature of spray dryer 185 DEG C, leaving air temp 85 DEG C, it is ground into powder subsequently, makes dried cream powder;

Second step: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.4 times and 0.4 times in the dried cream powder obtained, make granule, dries in 75 DEG C, it is thus achieved that granule.

Hereinafter adopt embodiment to describe embodiments of the present invention in detail, fully understand that how application technology means are to solve technical problem for the present invention, reach technique effect and implement according to this whereby.

Embodiment 1: capsule

Take Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 110g, Herba Peperomiae Dindygulensis 60g, Herba Scutellariae indicae 80g, Herba Sonchi Arvensis 320g, bitter 490g, Herba Polygoni Orientalis root 260g, Radix Tricalysiae dubiae 70g, Herba Lysimachiae Insignis 460g, Radix Crataevae Unilocularis 140g, butterfly rattan 220g, white branch and leaf 130g, Radix pterocaryae stenopterae 240g, Radix et Rhizoma Thalictri Faberi 580g and Herba ophiorrhizae japonicae 340g;

Prepare according to the following steps:

The first step, is mixed in proportion each for described Chinese medicine composition raw medicinal material, adds the ethanol that determining alcohol is 80% relative to mixture quality 4 times, is heated to reflux 60 minutes, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80% relative to medicinal residues quality 3 times, be heated to reflux 30 minutes, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;

Second step, by the first step obtain dry cream be placed in super micron mill pulverize 1 hour, pulverize and sieve obtain 200 orders micropowders;

3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.4 times, the starch of 0.4 times, the magnesium stearate of 0.03 times, carries out mixing process, namely obtains capsule 's content, described Capsule content is loaded in capsule housing, namely obtains capsule finished product.

Embodiment 2 granule

Take Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 130g, Herba Peperomiae Dindygulensis 90g, Herba Scutellariae indicae 70g, Herba Sonchi Arvensis 350g, bitter 460g, Herba Polygoni Orientalis root 280g, Radix Tricalysiae dubiae 50g, Herba Lysimachiae Insignis 480g, Radix Crataevae Unilocularis 110g, butterfly rattan 250g, white branch and leaf 120g, Radix pterocaryae stenopterae 220g, Radix et Rhizoma Thalictri Faberi 560g and Herba ophiorrhizae japonicae 320g;

Prepare according to the following steps:

The first step: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 90% relative to 3 times of mixture, heat to boiling reflux 2 hours, filter, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 75 DEG C subsequently under vacuum 0.01Mpa is the mastic of 1.05, spray drying, the inlet temperature of spray dryer 180 DEG C, leaving air temp 80 DEG C, it is ground into powder subsequently, makes dried cream powder;

Second step: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.5 times and 0.5 times in the dried cream powder obtained, make granule, dries in 70 DEG C, it is thus achieved that granule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 30～30g, carries out acute toxicity test. Mice is randomly divided into two groups, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.48g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.4 crude drugs/kg), and matched group gives normal saline, within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll. Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal. Capsule LD50 > 42.4 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 84.8 crude drugs/kg/ day. The Chinese medicine clinical application amount of the present invention be 8.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day. By weighing machine: 606 times that the dosis tolerata of the Chinese medicine of mice (average weight with 25g) the oral administration gavage present invention is quantity. Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention to three groups of mices (often group 20) by 13.88,22.32 and 43.56g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, Organs of Mice is all without substantially changing. Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.

Clinical data:

Case selection: whole 96 example cases are my Out-patient Department patient. Patient is randomly divided into treatment group and matched group, wherein, treatment group 48 people, male 22 people, women 26 people, 18～53 years old age; The course of disease 1～34 month. Matched group 48 people, male 19 people, women 29 people, 18～50 years old age; The course of disease 1～32 month. Two groups there was no significant difference through statistical analysis in sex, age, the course of disease and coincident with severity degree of condition etc., have comparability.

Diagnostic criteria: the diagnostic criteria with reference in " guideline of clinical investigations of new Chinese medicine treatment allergic cutaneous vasculitis " in " new Chinese medicine guideline of clinical investigations (the 3rd volume) " that Ministry of Public Health is developed and published for 1997: primary disease often betides youth of both sexes, in acute onset, chronic process, recurrent exerbation; Skin lesion is apt to occur in lower limb, and particularly shank and instep, symmetrical; Skin lesion multiform, often has pimple, purpura, tuberosity, necrosis and a ulcer etc., and its purpuric maculopapule (i.e. raised palp ecchymosis, scarlet in aubergine, press colour-fast) there is characteristic; Conscious pain or scorching hot sufferings; Lab testing can have eosinophil leucocyte to increase, and acute stage platelet reduces, and erythrocyte sedimentation rate is accelerated, and anti-" O " increases, and renal involvement can have albuminuria, hematuria and cast, and total complement of serum can reduce; Histopathological examination display corium leukocytoclastic angiitis.

Therapeutic Method:

Matched group: oral prednisone acetate tablets, each 10mg, every day 3 times, when the scope relatively baseline decline >=90% of skin lesion, drug dose reduces by half; Companion the infected, adds with Roxithromycin Tablets, each 0.15g, every day 2 times; Within 2 weeks, it is 1 course for the treatment of, treats 2 courses for the treatment of.

Treatment group: on matched group western medicine routine treatment basis, oral Chinese medicine embodiment 1 capsule of the present invention, each 2, every day 3 times; Within 2 weeks, it is 1 course for the treatment of, treats 2 courses for the treatment of.

Curative effect judging standard: cure: no conscious sympton, ulcer healing, tuberosity disappears, and other skin lesion also disappear, and only leaves over local cicatrix or pigmentation, and histopathological examination has recovered normal, follows up a case by regular visits to more than 3 months without recurrence. Effective: skin lesion disappears>=70%, and symptom disappears substantially; Or skin lesion disappear latter 3 months in still have slight recurrence; Or after skin lesion recovery from illness, histopathological examination vasculitis not yet all disappears. Effective: 30%≤skin lesion disappears, and<70%, alleviation of pain of itching is light. Invalid: skin lesion disappears less than 30%, even adds severe one.

Therapeutic outcome: see following table.

Group	n	Cure	Effective	Effectively	Invalid	Total effective
							Treatment group	48	30	10	5	3	45 (93.75%)
Matched group	48	14	15	9	10	38 (79.17%)

Treatment group and matched group comparison therapy group curative effect are better than matched group, two groups of Different therapeutical effects statistically significant (P < 0.05).

Untoward reaction: in matched group, there is nauseating, loss of appetite in 3 examples, and menoxenia occurs in 1 example, and cardiopalmus occur in 2 examples, without hepatic and renal function injure or other obvious adverse reaction. There is not hepatic and renal function injure or other untoward reaction in treatment group.

Concrete case: Wang, male, 36 years old. Course of disease a year and a half has a surplus, and repeatedly recurs after treatment. Before 5 days, lower limb start erythema occur, and then form tuberosity and ulcer, see a doctor to the court, it is seen that purpura, tuberosity, ulcer, scorching hot pain; Companion's arthralgia; Blood, urine, feces are conventional normal; Red tongue, yellow fur, slippery and rapid pulse, diagnose as allergic cutaneous vasculitis. Giving oral prednisone acetate tablets, each 10mg, every day 3 times, when the scope relatively baseline decline >=90% of skin lesion, drug dose reduces by half; Oral Chinese medicine embodiment 1 capsule of the present invention, each 2, every day 3 times; After treating 3 weeks, no conscious sympton, ulcer healing, tuberosity disappears, and other skin lesion also disappear, and only leaves over local cicatrix or pigmentation, and histopathological examination has recovered normal, follows up a case by regular visits to 6 months without recurrence, cures.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above. But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.

Claims (8)

1. the Chinese medicine treating allergic cutaneous vasculitis, it is characterised in that each raw medicinal material of described Chinese medicine includes: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Herba Peperomiae Dindygulensis, Herba Scutellariae indicae, Herba Sonchi Arvensis, bitter, Herba Polygoni Orientalis root, Radix Tricalysiae dubiae, Herba Lysimachiae Insignis, Radix Crataevae Unilocularis, butterfly rattan, white branch and leaf, Radix pterocaryae stenopterae, Radix et Rhizoma Thalictri Faberi and Herba ophiorrhizae japonicae.

2. Chinese medicine as claimed in claim 1, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10～20 parts, Herba Peperomiae Dindygulensis 5～15 parts, Herba Scutellariae indicae 5～15 parts, Herba Sonchi Arvensis 30～40 parts, bitter 45～55 parts, Herba Polygoni Orientalis root 25～35 parts, Radix Tricalysiae dubiae 5～15 parts, Herba Lysimachiae Insignis 45～55 parts, Radix Crataevae Unilocularis 10～20 parts, 20～30 parts of butterfly rattan, 10～20 parts of white branch and leaf, Radix pterocaryae stenopterae 20～30 parts, Radix et Rhizoma Thalictri Faberi 55～65 parts and Herba ophiorrhizae japonicae 30～40 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10～15 parts, Herba Peperomiae Dindygulensis 5～10 parts, Herba Scutellariae indicae 5～10 parts, Herba Sonchi Arvensis 30～35 parts, bitter 45～50 parts, Herba Polygoni Orientalis root 25～30 parts, Radix Tricalysiae dubiae 5～10 parts, Herba Lysimachiae Insignis 45～50 parts, Radix Crataevae Unilocularis 10～15 parts, 20～25 parts of butterfly rattan, 10～15 parts of white branch and leaf, Radix pterocaryae stenopterae 20～25 parts, Radix et Rhizoma Thalictri Faberi 55～60 parts and Herba ophiorrhizae japonicae 30～35 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 11 parts, Herba Peperomiae Dindygulensis 6 parts, Herba Scutellariae indicae 8 parts, Herba Sonchi Arvensis 32 parts, bitter 49 parts, Herba Polygoni Orientalis root 26 parts, Radix Tricalysiae dubiae 7 parts, Herba Lysimachiae Insignis 46 parts, Radix Crataevae Unilocularis 14 parts, 22 parts of butterfly rattan, 13 parts of white branch and leaf, Radix pterocaryae stenopterae 24 parts, Radix et Rhizoma Thalictri Faberi 58 parts and Herba ophiorrhizae japonicae 34 parts.

5. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine composition raw medicinal material, adds the ethanol that determining alcohol is 80～90% relative to mixture quality 3～5 times, is heated to reflux 40～60 minutes, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to medicinal residues quality 2～3 times, be heated to reflux 30～50 minutes, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes and sieves the micropowders of acquisition 100～200 order;

3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3～0.5 times, the starch of 0.3～0.5 times, the magnesium stearate of 0.005～0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is loaded in capsule housing, namely obtains capsule finished product.

6. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 70～80% relative to 4～6 times of mixture, heat to boiling reflux 2～3 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 70～80 DEG C subsequently under vacuum 0.01～0.05Mpa is the mastic of 1.03～1.05, spray drying, the inlet temperature of spray dryer 165～185 DEG C, leaving air temp 65～85 DEG C, it is ground into powder subsequently, makes dried cream powder;

Second step: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.4～0.6 times and 0.4～0.6 times in the dried cream powder obtained, make granule, dries in 65～75 DEG C, it is thus achieved that granule.

7. the preparation method of Chinese medicine described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine composition raw medicinal material, adds the ethanol that determining alcohol is 80～90% relative to mixture quality 3～5 times, is heated to reflux 40～60 minutes, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to medicinal residues quality 2～3 times, be heated to reflux 30～50 minutes, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes and sieves the micropowders of acquisition 100～200 order;

3rd step, the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3～0.5 times, the starch of 0.3～0.5 times, the magnesium stearate of 0.005～0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is loaded in capsule housing, namely obtains capsule finished product.

8. the preparation method of Chinese medicine described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 70～80% relative to 4～6 times of mixture, heat to boiling reflux 2～3 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 70～80 DEG C subsequently under vacuum 0.01～0.05Mpa is the mastic of 1.03～1.05, spray drying, the inlet temperature of spray dryer 165～185 DEG C, leaving air temp 65～85 DEG C, it is ground into powder subsequently, makes dried cream powder;

Second step: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.4～0.6 times and 0.4～0.6 times in the dried cream powder obtained, make granule, dries in 65～75 DEG C, it is thus achieved that granule.