CN107693767B

CN107693767B - External traditional Chinese medicine composition for preventing and treating diabetic foot, and preparation method and application thereof

Info

Publication number: CN107693767B
Application number: CN201711205856.2A
Authority: CN
Inventors: 郭晶涵
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-11-27
Filing date: 2017-11-27
Publication date: 2020-10-27
Anticipated expiration: 2037-11-27
Also published as: CN107693767A

Abstract

The invention discloses an external traditional Chinese medicine composition for preventing and treating diabetic foot, which comprises the following raw materials: radix astragali, radix Cyathulae, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, Carthami flos, caulis Spatholobi, rhizoma Atractylodis, ramulus Cinnamomi, herba asari, Zingiberis rhizoma, radix Aconiti, herba Ephedrae, radix et rhizoma Rhei, cortex Phellodendri, Natrii sulfas, herba Violae, semen Strychni, Glycyrrhrizae radix, Lumbricus, Olibanum, Myrrha, radix Angelicae Dahuricae, and spina Gleditsiae. The invention also discloses a preparation method and application of the external traditional Chinese medicine composition for preventing and treating diabetic foot. The invention has the effects of promoting blood circulation and promoting qi circulation, warming channels and expelling cold, removing blood stasis and relieving pain, clearing heat and detoxicating, and removing putrefaction and promoting tissue regeneration through dialectic compatibility and assistance of various traditional Chinese medicines. Has definite curative effect on the prevention and treatment of the diabetic foot, has no toxic or side effect, and ensures that the patient is not easy to relapse after being cured.

Description

External traditional Chinese medicine composition for preventing and treating diabetic foot, and preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to an external traditional Chinese medicine composition for preventing and treating diabetic foot, and a preparation method and application thereof.

Background

Diabetes Mellitus (DM) is a common endocrine-metabolic disease mainly characterized by metabolic disorders such as sugar, fat, and protein due to insufficient insulin secretion or defective function in vivo. In recent years, with the improvement of living standard and lifestyle change of people, the incidence rate of diabetes in the world is rapidly increased, and diabetes has become a third most serious common disease after tumor and cardiovascular disease threatening human health and life. Diabetes does not necessarily cause serious harm to patients, but long-term blood sugar is increased, large blood vessels and micro blood vessels are damaged and endanger the heart, brain, kidney, peripheral nerves, eyes, feet and the like, and a series of diabetic complications can be caused along with the progress of the disease course of the patients.

The diabetic complications mainly comprise various diseases such as diabetic foot, diabetic eye disease, diabetic nephropathy, diabetic neuropathy, diabetic cardiovascular disease and the like. Among them, the concept of diabetic foot was first proposed by Oakley in 1956, and in 1972 Catterall defined it as a foot that lost sensation due to neuropathy and vitality due to ischemia, with infection. The World Health Organization (WHO) definition is: foot infections, ulcers and/or deep tissue destruction associated with abnormalities of the distal nerves of the lower extremities and varying degrees of peripheral vasculopathy. The Wagner classification method classified the diabetic foot into the following 5 grades:

level 0: the skin has no open focus. It is often manifested as insufficient blood supply to the extremities, weak pulse of the dorsum of the foot, cool skin, purple brown color, numbness, stabbing pain, burning pain, slow or lost sensation, and accompanied with high risk of foot manifestations such as deformity of the toes or feet.

Level 1: the limb skin has open lesions. Blisters, blebs, corns or calluses, frostbite or scald and other superficial skin ulcers caused by skin lesions. But the lesions have not yet spread to deep tissues.

And 2, stage: the infected lesion has invaded deep muscle tissue. Cellulitis, multiple pus foci and sinus formation, or infection along the muscle gap and enlargement of the foot sole and instep penetrating ulcer, with more purulent secretion, but without destruction of the tendon and ligament.

And 3, level: tendon and ligament tissues are destroyed, cellulitis is fused to form large pus cavities, purulent secretion and necrotic tissues are increased, but the destruction of bone is not obvious.

4, level: severe infections have resulted in bone defects, osteomyelitis and destruction of bone joints or the formation of pseudojoints.

And 5, stage: most or all of the feet are infected or ischemic, resulting in severe wet or dry necrosis. The dark extremities, the trunk of the body, and the frequent spread of the ankle and lower leg.

The number of diabetic gangrene or amputation is 15-40 times more than that of the general people. The diabetic foot amputation is performed every 30 seconds in the world, the quality of life of the diabetic foot amputation is obviously reduced, physical and psychological damage is caused to the diabetic foot patient, the death rate of the diabetic foot patient after operation is high, the death rate in 6 months is 20%, and the death rate after amputation for 5 years is even as high as 50% -70%. Therefore, it is of great importance to develop early prevention and middle-to-late treatment of foot problems in diabetic patients.

At present, western medicine treatment of diabetic foot mainly includes application of insulin and/or oral hypoglycemic drugs to control blood sugar, intravenous application of drugs for promoting blood circulation to remove blood stasis to improve microcirculation, application of antibiotics to resist infection, etc., and although corresponding symptoms can be relieved to a certain extent, the pain of patients cannot be fundamentally removed. If the treatment still fails to alleviate and control the symptoms and complications of the lower limb, amputation will eventually occur.

The traditional Chinese medicine considers that the diabetic foot is mainly caused by deficiency of yin of the body, weak five internal organs, deficiency of kidney yin and dryness-heat of lung and stomach due to improper diet, overeating, emotional disorder and excessive desire; the key point of the pathogenesis is yin deficiency and dryness heat, while yin deficiency is the basis and dryness heat is the index; prolonged illness, impairment of yin involving yang, deficiency of both yin and yang; yin deficiency with dryness-heat consuming fluid and burning fluid, causing blood to be viscous and blood to be stagnant with astringency; yin impairment affecting yang and yang deficiency leading to congealing cold can also lead to blood stasis and yang within the blood. The disease is mostly caused by deficiency of origin and excess of origin, with deficiency of qi, blood, yin and yang as the origin, and obstruction of collaterals, blood stasis, damp-heat and fire-toxin as the targets. Clinically, diabetic foot usually has the manifestations of ischemia, peripheral neuropathy, infection, etc. Especially, in the later period, the foot or limb remote local soft tissue skin erosion is firstly blister or shallow ulcer, and then the ulcer goes deep into tendon and muscular layer to destroy bone, so that the tissue is necrotic and rotten to form pustule cavity and sinus, foul and odor secretion is discharged, and the periphery is in hyperplastic solid swelling.

Clinical practices in recent years show that the traditional Chinese medicine has great advantages in treating diabetic foot, obtains remarkable curative effect and accumulates abundant experiences. Compared with western medicines, the traditional Chinese medicine treatment overcomes the drug resistance defect possibly caused by external antibiotics, and the traditional Chinese medicine external prescription directly acts on local focus of diabetic foot, so that the medicine can directly reach the focus, the safety is higher, the side effect is less, and a considerable part of patients are prevented from amputation.

Disclosure of Invention

On the basis of the research on the dialectical theory of traditional Chinese medicine for diabetic foot, the inventor screens and compounds a plurality of traditional Chinese medicines through years of clinical tests to obtain the formula of the invention.

The invention aims to provide an external traditional Chinese medicine composition for preventing and treating diabetic foot, which has scientific and reasonable formula compatibility, definite curative effect, convenient use, good patient compliance, no toxic or side effect and difficult relapse, and a preparation method and application thereof.

Specifically, in order to achieve the above purpose, the first aspect of the present invention provides an external traditional Chinese medicine composition for preventing and treating diabetic foot, wherein the traditional Chinese medicine composition comprises the following raw materials by weight: the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 30-150 parts of astragalus membranaceus, 15-30 parts of medicinal cyathula root, 5-15 parts of angelica sinensis, 5-15 parts of ligusticum wallichii, 5-10 parts of safflower, 15-30 parts of caulis spatholobi, 5-15 parts of rhizoma atractylodis, 15-30 parts of cassia twig, 5-10 parts of asarum, 10-20 parts of rhizoma zingiberis, 5-15 parts of radix aconiti, 5-10 parts of ephedra, 15-30 parts of rheum officinale, 5-15 parts of golden cypress, 10-20 parts of mirabilite, 5-15 parts of Chinese violet, 5-10 parts of nux vomica, 5-10 parts of liquorice, 5-15 parts of lumbricus, 5-15 parts of frankincense, 5-15 parts of myrrh, 5-20 parts of radix angelicae and 15.

Further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 60-120 parts of astragalus membranaceus, 18-25 parts of medicinal cyathula root, 8-12 parts of angelica sinensis, 5-12 parts of ligusticum wallichii, 5-10 parts of safflower, 18-24 parts of caulis spatholobi, 10-15 parts of rhizoma atractylodis, 18-24 parts of cassia twig, 5-10 parts of asarum, 12-16 parts of rhizoma zingiberis, 5-12 parts of radix aconiti, 5-10 parts of ephedra, 20-30 parts of rheum officinale, 5-15 parts of golden cypress, 15-20 parts of mirabilite, 8-15 parts of Chinese violet, 5-10 parts of nux vomica, 5-10 parts of liquorice, 10-15 parts of lumbricus, 5-15 parts of frankincense, 5-12 parts of myrrh, 10-20 parts of radix angelicae and 15.

Further, the weight parts of the raw materials are as follows: 100 parts of astragalus mongholicus, 20 parts of medicinal cyathula root, 10 parts of Chinese angelica, 9 parts of ligusticum wallichii, 8 parts of safflower carthamus, 20 parts of caulis spatholobi, 15 parts of rhizoma atractylodis, 20 parts of cassia twig, 6 parts of asarum, 15 parts of dried ginger, 10 parts of monkshood, 5 parts of ephedra, 22 parts of rheum officinale, 12 parts of golden cypress, 15 parts of mirabilite, 11 parts of philippine violet herb, 7 parts of nux vomica, 10 parts of liquorice, 12 parts of earthworm, 10 parts of frankincense, 8 parts of myrrh, 16 parts of radix.

Furthermore, when the traditional Chinese medicine composition is used, one or more traditional Chinese medicines for improving or treating concurrent symptoms can be added.

Further, the traditional Chinese medicine composition is prepared into powder or paste.

The second aspect of the invention provides a preparation method of the external traditional Chinese medicine composition for preventing and treating diabetic foot, wherein the traditional Chinese medicine composition is a powder preparation, and the preparation method comprises the following steps:

weighing the dried raw materials in corresponding parts by weight according to the mixture ratio of the composition, crushing the raw materials by a crusher, sieving the crushed raw materials by a sieve of 40-60 meshes, and uniformly mixing the crushed raw materials to obtain a finished powder of the medicine.

The using method comprises the following steps: weighing the 50-55 g of powder finished product, adding a proper amount of water (based on the amount of the water surface capable of being soaked into the inner and outer ankles of the foot after decoction), soaking for 10 minutes, boiling for 20 minutes, standing for cooling, keeping the temperature of the liquid medicine at 40 ℃, and soaking the feet in the liquid medicine for 30-45 minutes. Soaking feet for 2 times every day, and 30 days is a treatment course. Is suitable for 0-grade diabetic foot patients without ulcer surface on foot.

Further, the traditional Chinese medicine composition is an ointment, and the preparation method comprises the following steps:

weighing the dried raw materials in corresponding parts by weight according to the proportion of the composition, coarsely crushing, adding water in an amount which is 6-8 times the total weight of the raw materials, decocting for 1-2 hours, filtering, adding water in an amount which is 3-4 times the total weight of the raw materials into filter residues, decocting for 0.5-1 hour, filtering, combining the two decoction filtrates, concentrating the filtrate to obtain clear paste with the relative density of 1.18-1.22 at 70 ℃, adding a pharmaceutically acceptable carrier into the clear paste, stirring, mixing uniformly, refining slightly, collecting the paste to the relative density of 1.48-1.55, and cooling to obtain the finished paste of the medicine.

Wherein, the carrier refers to a conventional drug carrier in the field of pharmacy. Vaseline or glycerol is preferred.

The using method comprises the following steps: the paste is evenly applied to the focus three times a day, and 30 days is a treatment course. Is suitable for patients with diabetes of above grade 1 with ulcer surface on foot.

The third aspect of the invention provides an application of the external traditional Chinese medicine composition in preparing a medicine for preventing and treating diabetic foot.

The pharmacological effects of the selected traditional Chinese medicines are as follows:

astragalus root: sweet and slightly warm in taste. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Has effects of invigorating qi, consolidating superficial resistance, arresting sweating, promoting granulation, inducing diuresis, and relieving swelling. Can be used for treating deficiency of vital energy, asthenia, collapse of middle-warmer energy, chronic diarrhea, proctoptosis, hematochezia, metrorrhagia, superficial deficiency, spontaneous perspiration, carbuncle, cellulitis, intractable ulcer, blood deficiency, sallow complexion, internal heat, diabetes, chronic nephritis, albuminuria, diabetes, etc. Huang Qi Zhi has the actions of tonifying qi and strengthening middle energizer, while the raw one is used for strengthening exterior and relieving sore.

Radix cyathulae: sweet, slightly bitter and neutral in nature. It enters liver and kidney meridians. Dispersing and descending, and has effects of promoting blood circulation, dredging channels, dispelling pathogenic wind, removing dampness, promoting articulation, and inducing diuresis for treating stranguria.

Chinese angelica: sweet and pungent in flavor and warm in nature. It enters liver, heart and spleen meridians. The functional indications are as follows: tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.

Ligusticum wallichii: pungent flavor and warm nature. It enters liver, gallbladder and heart meridians. It is commonly used for promoting blood circulation and activating qi-flowing, dispelling pathogenic wind and relieving pain, rhizoma Ligustici Chuanxiong is pungent, warm, fragrant and dry, and can disperse and ascend to the vertex; it enters the blood system and goes down to reach the blood sea. Promoting blood circulation and removing blood stasis, and is suitable for various diseases caused by blood stasis; it has good effect in dispelling pathogenic wind and relieving pain, and can be used for treating headache, rheumatalgia, etc. Xiren is that Chuan Xiong is a qi-flowing medicine in blood, but it has the functions of dispersing acrid, relieving depression, dredging and relieving pain.

Safflower: pungent flavor and warm nature. It enters heart and liver meridians. The functional indications are as follows: promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, traumatic injury, and swelling and pain of skin and external diseases.

Caulis spatholobi: bitter and sweet in taste and warm in nature. It enters liver and kidney meridians. The functional indications are as follows: tonify blood, activate blood and dredge collaterals. Can be used for treating menoxenia, blood deficiency, sallow complexion, numbness, paralysis, and rheumatalgia.

Rhizoma atractylodis: pungent and bitter with warm nature. It enters spleen, stomach and liver meridians. The functional indications are as follows: dry dampness and invigorate spleen, dispel wind and cold, improve vision. Can be used for treating abdominal distention, diarrhea, edema, tinea pedis, paralysis 36484m, rheumatalgia, common cold due to wind-cold evil, and night blindness.

Cassia twig: pungent and sweet in flavor and warm in nature. It enters heart, lung and bladder meridians. The functional indications are as follows: induce sweating to relieve muscles, warm and dredge meridians, strengthen yang to transform qi, and smooth the flow of qi. Can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping.

Asarum: pungent flavor and warm nature. It enters heart, lung and kidney meridians. The functional indications are as follows: dispel wind and cold, induce resuscitation and alleviate pain, warm lung and resolve retained fluid. Can be used for treating wind-cold type common cold, headache, toothache, nasal obstruction, nasosinusitis, rheumatalgia, phlegm retention, asthma, and cough.

Dried ginger: pungent flavor and warm property. It enters spleen, stomach, kidney, heart and lung meridians. The functional indications are as follows: gan Jiang warms the middle-jiao to dispel cold, returns yang to activate collaterals, eliminates dampness and eliminates phlegm. Can be used for treating abdominal psychroalgia, emesis, diarrhea, cold limbs, slight pulse, phlegm retention, asthma, and cough.

Radix aconiti: pungent, bitter and warm in flavor. It enters heart, liver, kidney and spleen meridians. Has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain. The main treatment is as follows: can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, and anesthesia and pain relieving.

Herba ephedrae: pungent, slightly bitter and warm in nature. It enters lung meridian and bladder meridian. The efficacy and the effect are as follows: induce sweating and dispel cold, ventilate lung and relieve asthma, induce diuresis to alleviate edema. Herbs with pungent and warm natured exterior-releasing herbs belong to the category of exterior-releasing herbs.

Rhubarb: bitter taste and cold nature. It enters spleen, stomach, large intestine, liver and pericardium meridians. The functional indications are as follows: purge heat and unblock intestines, cool blood and remove toxicity, dispel stasis and dredge meridians. Used for treating excessive heat constipation, abdominal pain due to stagnation, dysentery, damp-heat jaundice, blood heat hematemesis, conjunctival congestion, pharyngeal swelling, acute appendicitis, abdominal pain, carbuncle, furuncle, amenorrhea due to blood stasis, traumatic injury, and scald due to hot water and fire; upper gastrointestinal hemorrhage. The wine rhubarb is good at clearing heat and toxicity in the upper jiao and blood system. It can be used for treating conjunctival congestion, pharyngeal swelling, and gingival swelling and pain. The cooked rhubarb has the functions of relieving the purgation, purging fire and removing toxicity. It can be used for treating pyocutaneous disease due to fire toxin. Rhubarb charcoal cools blood, removes stasis and stops bleeding. Can be used for treating blood heat with blood stasis and hemorrhage.

Phellodendron bark: bitter taste and cold nature. It enters kidney and bladder meridians. The functional indications are as follows: clear heat and dry dampness, purge fire and remove steam, remove toxicity and cure sore. Can be used for treating dysentery due to damp-heat pathogen, jaundice, leukorrhagia, stranguria with heat pathogen, tinea pedis, flaccidity { exorcism }, hectic fever due to yin-deficiency, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, eczema, and pruritus. Salted cortex phellodendri is used for nourishing yin and reducing internal heat. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.

Mirabilite: salty, bitter and cold in nature. It enters stomach and large intestine meridians. The functional indications are as follows: purge heat and relax bowels, moisten dryness and soften hard mass, clear fire and relieve swelling. Used for treating excessive heat constipation, abdominal pain due to stagnation, and intestinal abscess with swelling and pain; it is indicated for acute mastitis, hemorrhoid with swelling and pain.

Herba Violae: bitter and pungent in flavor and cold in nature. It enters heart and lung meridians. Has the functions of clearing away heat and toxic material, cooling blood and detumescence, clearing away heat and promoting diuresis, and is mainly used for treating furuncle, carbuncle swelling, scrofula, jaundice, dysentery, diarrhea, conjunctival congestion, pharyngitis and venomous snake bite.

Nux vomica: bitter taste and warm nature. It enters liver and spleen meridians. Has effects of dredging collaterals, relieving pain, resolving hard mass and eliminating swelling. The main treatment is as follows: traumatic injury, fracture, rheumatism, paralysis, carbuncle, sore, and sore throat.

Licorice root: sweet in nature and taste, neutral in nature. It enters heart, lung, spleen and stomach meridians. The functional indications are as follows: invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Earthworm: salty taste and cold nature. It enters liver, spleen and bladder meridians. The functional indications are as follows: clear heat and calm fright, dredge meridians, relieve asthma and induce diuresis. Can be used for treating hyperpyrexia, unconsciousness, epilepsy, convulsion, arthralgia, numbness of limbs, hemiplegia, cough and asthma due to lung heat, oliguria, edema, and hypertension.

Frankincense: pungent, bitter and warm in nature. It enters heart, liver and spleen meridians. The efficacy is as follows: promote blood circulation, move qi and alleviate pain, resolve swelling and promote tissue regeneration. The main treatment is as follows: can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal pain, rheumatic arthralgia, spasm of muscles and tendons, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Myrrh: pungent and bitter in flavor and mild in nature. It enters heart, liver and spleen meridians. The efficacy is as follows: dispel stasis, relieve pain, resolve swelling and promote tissue regeneration. The main treatment is as follows: can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal mass, rheumatic arthralgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Radix angelicae: pungent flavor and warm nature. It enters stomach, large intestine and lung meridians. The functional indications are as follows: remove dampness, induce resuscitation, alleviate pain, relieve swelling and expel pus. Can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain.

Spina gleditsiae: pungent flavor and warm nature. It enters liver and stomach meridians. The functional indications are as follows: detumescence, expelling toxin, expelling pus and killing parasites. Can be used for treating early carbuncle and cellulitis or suppurative abscess; it is indicated for external treatment of scabies and leprosy.

The invention has the following advantages:

1. the invention adopts dialectical compatibility of various traditional Chinese medicines and assists with each other, wherein, the astragalus root is a monarch drug for tonifying middle-jiao and Qi; radix cyathulae, angelica, ligusticum wallichii, safflower and caulis spatholobi are ministerial drugs for promoting blood circulation and removing blood stasis; rhizoma atractylodis, cassia twig, asarum, dried ginger, radix aconiti and ephedra are used as adjuvant drugs for dispelling dampness and cold; the rhubarb, the phellodendron, the mirabilite, the Chinese violet, the nux vomica, the liquorice, the earthworm, the frankincense, the myrrh, the angelica dahurica and the spina gleditsiae are used as guiding drugs for clearing away heat and toxic materials and removing putrefaction and promoting tissue regeneration, and the efficacy of promoting blood circulation and promoting qi circulation, warming channels and dispelling cold, removing blood stasis and relieving pain, clearing away heat and toxic materials and removing putrefaction and promoting tissue. The powder has good curative effect on the prevention and treatment of diabetic foot, and has the health-care functions of strengthening physique and controlling the development of diabetic foot by adopting the powder for foot bath treatment of a 0-grade diabetic foot patient without an ulcer surface; for the patients with the diabetic foot of more than level 1 of the existing ulcer surface, the paste is adopted for coating treatment, so that the pain of the patients can be relieved, the infection of the ulcer surface can be controlled, the local microcirculation can be improved, the bidirectional transfer function of endothelial cells can be enhanced, the conduction speed of peripheral nerves can be increased, and the tissue repair and the healing of wound surfaces can be promoted.

2. The raw materials of the invention are easy to obtain and have low cost, the preparation method is simple and easy to operate, the obtained traditional Chinese medicine composition has definite curative effect on the prevention and treatment of the diabetic foot, has no toxic or side effect, and is not easy to relapse after the patient is cured.

Detailed Description

The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.

Example 1

An external traditional Chinese medicine composition for preventing and treating diabetic foot comprises the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 15 parts of medicinal cyathula root, 5 parts of angelica sinensis, 5 parts of ligusticum wallichii, 5 parts of safflower, 15 parts of caulis spatholobi, 5 parts of rhizoma atractylodis, 15 parts of cassia twig, 5 parts of asarum, 10 parts of dried ginger, 5 parts of monkshood, 5 parts of ephedra, 15 parts of rheum officinale, 5 parts of cortex phellodendri, 10 parts of mirabilite, 5 parts of philippine violet herb, 5 parts of nux vomica, 5 parts of liquorice, 5 parts of earthworm, 5 parts of frankincense, 5 parts of myrrh, 5 parts of radix angelicae.

The preparation method and the using method of the traditional Chinese medicine composition powder agent of the embodiment are as follows:

weighing the dried raw materials in parts by weight, crushing the raw materials by a crusher, sieving the crushed raw materials by a 40-60-mesh sieve, and uniformly mixing the crushed raw materials to obtain a finished powder of the medicine; weighing 50-55 g of the powder, adding a proper amount of water (based on the amount of the water surface capable of being soaked into the inner and outer ankles of the foot after decoction), soaking for 10 minutes, boiling for 20 minutes, standing for cooling, keeping the temperature of the liquid medicine at 40 ℃, and soaking the feet in the liquid medicine for 30-45 minutes. Soaking feet for 2 times every day, and 30 days is a treatment course.

The preparation method and the application method of the traditional Chinese medicine composition paste of the embodiment are as follows:

weighing the dried raw materials according to the weight parts, coarsely crushing, adding water of which the weight is 7 times of that of the raw materials, decocting for 1.5 hours, filtering, adding water of which the weight is 3 times of that of the raw materials into filter residues, decocting for 0.5 hour, filtering, combining decoction liquids of the two times, concentrating the filtrate to a clear paste with the relative density of 1.20 at 70 ℃, adding vaseline into the clear paste, stirring, mixing uniformly, refining slightly, collecting the paste to the relative density of 1.50, and cooling to obtain a finished paste product of the medicine. The ointment is uniformly applied to the focus, the thickness is about 0.2 cm, three times a day, and 30 days is a treatment course.

Example 2

An external traditional Chinese medicine composition for preventing and treating diabetic foot comprises the following raw materials in parts by weight: 60 parts of astragalus membranaceus, 18 parts of medicinal cyathula root, 6 parts of angelica sinensis, 8 parts of ligusticum wallichii, 5 parts of safflower, 15 parts of caulis spatholobi, 5 parts of rhizoma atractylodis, 18 parts of cassia twig, 5 parts of asarum, 12 parts of dried ginger, 5 parts of monkshood, 8 parts of ephedra, 18 parts of rheum officinale, 8 parts of cortex phellodendri, 12 parts of mirabilite, 8 parts of philippine violet herb, 5 parts of nux vomica, 5 parts of liquorice, 5 parts of earthworm, 10 parts of frankincense, 5 parts of myrrh, 5 parts of radix angelicae and 15 parts of spina gleditsiae, and the preparation method and.

Example 3

An external traditional Chinese medicine composition for preventing and treating diabetic foot comprises the following raw materials in parts by weight: 90 parts of astragalus membranaceus, 22 parts of medicinal cyathula root, 10 parts of angelica sinensis, 12 parts of ligusticum wallichii, 5 parts of safflower, 18 parts of caulis spatholobi, 10 parts of rhizoma atractylodis, 20 parts of cassia twig, 8 parts of asarum, 15 parts of rhizoma zingiberis, 9 parts of radix aconiti, 8 parts of ephedra, 23 parts of rheum officinale, 12 parts of cortex phellodendri, 16 parts of mirabilite, 10 parts of philippine violet herb, 8 parts of nux vomica, 6 parts of liquorice, 10 parts of earthworm, 12 parts of frankincense, 10 parts of myrrh, 10 parts of radix.

The preparation method and the using method of the traditional Chinese medicine composition of the embodiment are the same as those of the embodiment 1.

Example 4

An external traditional Chinese medicine composition for preventing and treating diabetic foot comprises the following raw materials in parts by weight: 100 parts of astragalus mongholicus, 20 parts of medicinal cyathula root, 10 parts of Chinese angelica, 9 parts of ligusticum wallichii, 8 parts of safflower carthamus, 20 parts of caulis spatholobi, 15 parts of rhizoma atractylodis, 20 parts of cassia twig, 6 parts of asarum, 15 parts of dried ginger, 10 parts of monkshood, 5 parts of ephedra, 22 parts of rheum officinale, 12 parts of golden cypress, 15 parts of mirabilite, 11 parts of philippine violet herb, 7 parts of nux vomica, 10 parts of liquorice, 12 parts of earthworm, 10 parts of frankincense, 8 parts of myrrh, 16 parts of radix.

Example 5

An external traditional Chinese medicine composition for preventing and treating diabetic foot comprises the following raw materials in parts by weight: 120 parts of astragalus membranaceus, 25 parts of medicinal cyathula root, 10 parts of angelica sinensis, 12 parts of ligusticum wallichii, 10 parts of safflower, 25 parts of caulis spatholobi, 12 parts of rhizoma atractylodis, 25 parts of cassia twig, 10 parts of asarum, 18 parts of dried ginger, 13 parts of monkshood, 10 parts of ephedra, 28 parts of rheum officinale, 15 parts of cortex phellodendri, 18 parts of mirabilite, 12 parts of philippine violet herb, 8 parts of nux vomica, 9 parts of liquorice, 15 parts of earthworm, 12 parts of frankincense, 10 parts of myrrh, 15 parts of radix angelicae and.

Example 6

An external traditional Chinese medicine composition for preventing and treating diabetic foot comprises the following raw materials in parts by weight: 150 parts of astragalus, 30 parts of medicinal cyathula root, 15 parts of angelica, 15 parts of szechuan lovage rhizome, 10 parts of safflower, 30 parts of suberect spatholobus stem, 15 parts of rhizoma atractylodis, 30 parts of cassia twig, 10 parts of asarum, 20 parts of dried ginger, 15 parts of common monkshood mother root, 10 parts of ephedra herb, 30 parts of rhubarb, 15 parts of amur corktree bark, 20 parts of mirabilite, 15 parts of philippine violet herb, 10 parts of nux vomica, 10 parts of liquorice, 15 parts of earthworm, 15 parts of frankincense, 15 parts of myrrh, 20 parts,

Test examples

In order to show the treatment effect of the traditional Chinese medicine composition on the diabetic foot patients with different grades, the invention carries out the following curative effect tests.

1. Patient data: 100 diabetic foot patients were selected for hospitalization from 8 to 2016 and 10 months. Wherein, 68 men and 32 women have age of 49-85 years, mean age of 61.2 years, and the course of diabetes is as follows: for 6-15 years, the diabetic foot course: patients are free of other serious diseases for 4 weeks to 5 years. All met the diagnostic criteria for diabetic feet, according to the clinical grading criteria (Wagner grading), with 26 cases on a 0-grade (no ulcer), 38 cases on a 1-grade (superficial ulcer), 18 cases on a 2-grade (deep ulcer without abscess formation and bone involvement), 12 cases on a 3-grade (deep ulcer with bone involvement such as cellulitis or abscess formation), and 6 cases on a 4-grade (local gangrene).

2. Standard of therapeutic effect

And (3) curing: after the patients are treated, the clinical symptoms disappear, the skin color of the patients of grade 0 returns to normal, and the ulcer of the patients of grade 1 or above is completely healed.

The effect is shown: after the patients are treated, the clinical symptoms disappear, the skin of the patients with grade 0 recovers to be normal, and most of the ulcer surfaces of the patients with grade 1 or above are recovered.

The method has the following advantages: after the patients are treated, the clinical symptoms are improved, the skin color of the patients of grade 0 gradually changes to light red, small parts of the ulcer surfaces of the patients of grade 1 are recovered, and new granulation tissues grow.

And (4) invalidation: after the treatment, the skin color of the patient is not changed, and the ulcer surface is not recovered.

3. Method of treatment

For the patients with diabetic foot of grade 0 without ulcer, the powder of the embodiment 4 is used for foot bath treatment, feet are soaked for 2 times a day, and 30 days is a treatment course. The paste of the embodiment 4 is applied to patients with diabetic foot of more than 1 grade with existing ulcer surfaces for treatment, three times a day, and 30 days is a treatment course. The traditional Chinese medicine is used for treating and simultaneously matched with the following treatment methods: 1) treating with insulin to control blood sugar to be 7-9 mmol/L; 2) treating patients with complicated infection with antiinflammatory and symptomatic treatment; 3) and (5) performing corresponding treatment on the wound surface of the affected foot.

4. Therapeutic results

By using the traditional Chinese medicine composition, the original symptoms are obviously relieved. According to statistics, patients with 0-grade diabetes and other mild symptoms can be cured in one treatment course, and 72 patients are cured after two treatment courses, wherein the treatment course accounts for 72 percent; 17 cases of obvious effect account for 17 percent; 11 effective cases account for 11%; there is no invalid case.

In the clinical test, the hematuria routine, the liver and kidney functions, the electrocardiogram and the like of the patients before and after the administration are checked and the details are recorded, and the traditional Chinese medicine composition has no toxic or side effect as shown by the comparison that no abnormality is found. The above cases were revisited one year later without recurrence.

Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. The external traditional Chinese medicine composition for preventing and treating diabetic foot is characterized by comprising the following raw materials in parts by weight: 100 parts of astragalus membranaceus, 20 parts of medicinal cyathula root, 10 parts of angelica sinensis, 9 parts of ligusticum wallichii, 8 parts of safflower, 20 parts of caulis spatholobi, 15 parts of rhizoma atractylodis, 20 parts of cassia twig, 6 parts of asarum, 15 parts of dried ginger, 10 parts of monkshood, 5 parts of ephedra, 22 parts of rheum officinale, 12 parts of cortex phellodendri, 15 parts of mirabilite, 11 parts of philippine violet herb, 7 parts of nux vomica, 10 parts of liquorice, 12 parts of earthworm, 10 parts of frankincense, 8 parts of myrrh, 16 parts of radix angelicae; the traditional Chinese medicine composition is prepared into powder or paste, the traditional Chinese medicine composition is powder, and the preparation method comprises the following steps:

weighing the dried raw materials in corresponding parts by weight according to the mixture ratio of the composition, crushing the raw materials by a crusher, sieving the crushed raw materials by a sieve of 40-60 meshes, and uniformly mixing the crushed raw materials to obtain a finished powder of the medicine;

the traditional Chinese medicine composition is an ointment, and the preparation method comprises the following steps:

weighing the dried raw materials in corresponding parts by weight according to the proportion of the composition, coarsely crushing, adding water in an amount which is 6-8 times the total weight of the raw materials, decocting for 1-2 hours, filtering, adding water in an amount which is 3-4 times the total weight of the raw materials into filter residues, decocting for 0.5-1 hour, filtering, combining decoction liquids of two times, concentrating the decoction liquid to obtain clear paste with the relative density of 1.18-1.22 at 70 ℃, adding a pharmaceutically acceptable carrier into the clear paste, stirring, mixing uniformly, refining slightly, collecting the paste to the relative density of 1.48-1.55, and cooling to obtain a finished paste product of the medicine.

2. The external traditional Chinese medicine composition for preventing and treating diabetic foot according to claim 1, wherein one or more traditional Chinese medicines for improving or treating concurrent symptoms can be added into the traditional Chinese medicine composition when in use.

3. The external traditional Chinese medicine composition for preventing and treating diabetic foot according to claim 1, wherein the carrier is vaseline or glycerol.

4. The use of the topical Chinese medicinal composition of claim 1 in the preparation of a medicament for the prevention and treatment of diabetic foot.