CN101590166B - Traditional Chinese medicine combination for treating gout and preparation method thereof - Google Patents

Traditional Chinese medicine combination for treating gout and preparation method thereof Download PDF

Info

Publication number
CN101590166B
CN101590166B CN2008101132125A CN200810113212A CN101590166B CN 101590166 B CN101590166 B CN 101590166B CN 2008101132125 A CN2008101132125 A CN 2008101132125A CN 200810113212 A CN200810113212 A CN 200810113212A CN 101590166 B CN101590166 B CN 101590166B
Authority
CN
China
Prior art keywords
chinese medicine
extract
preparing
medicine composition
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2008101132125A
Other languages
Chinese (zh)
Other versions
CN101590166A (en
Inventor
赵晓霞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Baode Runsheng Health Management Co.,Ltd.
Original Assignee
Beijing Increase Pharmaceutical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Increase Pharmaceutical Technology Co Ltd filed Critical Beijing Increase Pharmaceutical Technology Co Ltd
Priority to CN2008101132125A priority Critical patent/CN101590166B/en
Publication of CN101590166A publication Critical patent/CN101590166A/en
Application granted granted Critical
Publication of CN101590166B publication Critical patent/CN101590166B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses to a traditional Chinese medicine combination for treating gout and a preparation method thereof. The combination is prepared by rhizoma smilacis glabrae, ash bark, large-leaved gentian, red paeony root and plantain seed by a certain weight proportioning. The combination can be prepared into any kind of usual dosage form. The traditional Chinese medicine combination of the invention has the functions of clearing heat and drying damp, detoxicating, promoting diuresis and easing joint movement and is applied to treating gout.

Description

A kind of Chinese medicine composition that is used to treat gout and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition that is used to treat gout and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Gout is uric acid crystal and tissue injury's property disease of causing in purine metabolism obstacle and the blood in the body.Various disease conditions such as clinical characters is that hyperuricemia and the gouty arthritis that causes are thus shown effect repeatedly, tophus deposition, gouty kidney and dysbolismus pathological changes are shown effect for seeing with gouty arthritis repeatedly.The Along with people's living standard improves, the change of nutrition and diet structure, and the gout sickness rate is and obviously increases trend.
The traditional Chinese medical science thinks that the joint meridians that stagnate flow by the resistance of the turbid damp stasis of blood in gout system, and due to QI and blood was smooth, non-general ailment said due to cold or exposure was done.The heresy of turbid damp, non-receive in outside, and in main being born in.General patient with gout is mainly in middle-aged and elderly people, plump people, its internal organs degradation, if having a liking for the food greasy and surfeit flavour, infringement function of a specified duration is the most outstanding to damage the pure and impure metabolic function of spleen kidney especially.Dysfunction of the spleen in transportation, ascending the clear and descending the turbid is had no right, the weary gasification of kidney, separating clear and excreting turbid mistake department, water paddy is reforming not, gives birth in the turbid poison, is detained in the blood, with the capable distribution of blood, a series of pathological changes takes place.Diseases such as gouty arthritis are the marks of disease, purine metabolism obstacle (the pure and impure metabolism of spleen kidney) is not normal is only disease this, the turbid poison of uric acid is the middle pathological product of pathological changes, and produces disease such as gouty arthritis thus.
The inventor thinks that the cause of disease of gout mainly is that institute causes, is main so the rule of treatment is worked as with heat clearing and damp drying, detoxifcation, diuretic, easing joint movement by " give birth in damp and hot, the turbid poison, diseases caused by retention of fluid is stagnated ".
Summary of the invention
The present invention provides a kind of new Chinese medicine composition, and said composition has the effect of heat clearing and damp drying, detoxifcation, diuretic, easing joint movement, is used to treat gout.
Another object of the present invention provides the method for preparing of above-mentioned Chinese medicine composition.
The present invention realizes through following technical scheme:
The present invention is processed by the following weight proportion raw material: Rhizoma Smilacis Glabrae 15-60 part, Cortex Fraxini 6-12 part, Radix Gentianae Macrophyllae 3-9 part, Radix Paeoniae Rubra 6-12 part, Semen Plantaginis 9-15 part.
Preferred weight portion proportioning is: 30 parts of Rhizoma Smilacis Glabraes, 9 parts of Cortex Fraxinis, 6 parts of Radix Gentianae Macrophyllae, 9 parts of Radix Paeoniae Rubra, 12 parts of Semen Plantaginiss.
The method for preparing of Chinese medicine composition of the present invention is following:
Above medical material adds 8 times of amount 70% ethanol extractions, extracts each 1-1.5 hour 2 times; Being concentrated into relative density is the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa); Promptly get extract; Add appropriate amount of auxiliary materials, be prepared into pharmaceutically acceptable oral formulations, for example capsule, tablet, pill, drop pill etc.
The method for preparing of the preferred pill of Chinese medicine composition of the present invention is following:
Extract is ground into fine powder, adds proper honey, evenly mixed, the pill agent.
The method for preparing of Chinese medicine composition preferred capsule of the present invention agent is following:
Extract is ground into fine powder, adds lactose, mixing is used 95% alcohol granulation, and drying incapsulates, and promptly gets capsule.
The method for preparing of the preferred tablet of Chinese medicine composition of the present invention is following:
Extract is ground into fine powder, adds lactose, mixing is granulated, drying, and the adding magnesium stearate is an amount of, mixing, tabletting, coating promptly gets tablet.
The compatibility mechanism of pharmaceutical composition of the present invention is following:
The traditional Chinese medical science thinks that the joint meridians that stagnate flow by the resistance of the turbid damp stasis of blood in gout system, and due to QI and blood was smooth, non-general ailment said due to cold or exposure was done.The heresy of turbid damp, non-receive in outside, and in main being born in.General patient with gout is mainly in middle-aged and elderly people, plump people, its internal organs degradation, if having a liking for the food greasy and surfeit flavour, infringement function of a specified duration is the most outstanding to damage the pure and impure metabolic function of spleen kidney especially.Dysfunction of the spleen in transportation, ascending the clear and descending the turbid is had no right, the weary gasification of kidney, separating clear and excreting turbid mistake department, water paddy is reforming not, gives birth in the turbid poison, is detained in the blood, with the capable distribution of blood, a series of pathological changes takes place.Diseases such as gouty arthritis are the marks of disease, purine metabolism obstacle (the pure and impure metabolism of spleen kidney) is not normal is only disease this, the turbid poison of uric acid is the middle pathological product of pathological changes, and produces disease such as gouty arthritis thus.
The inventor thinks that the cause of disease of gout mainly is that institute causes, is main so the rule of treatment is worked as with heat clearing and damp drying, detoxifcation, diuretic, easing joint movement by " give birth in damp and hot, the turbid poison, diseases caused by retention of fluid is stagnated ".
In the drug composition, the mechanism of action of each medicine is following in the present invention:
Rhizoma Smilacis Glabrae: sweet, light, flat.Return liver, stomach warp.Dehumidifying, detoxifcation, easing joint movement.Be used for damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, the limbs contracture due to the scrofula, scabies, syphilis and mercurialism, bones and muscles pain.
Cortex Fraxini: bitter, puckery, cold.Return liver, gallbladder, large intestine channel.Heat clearing and damp drying, astringent therapy makes eye bright.Be used for hematodiarrhoea, have loose bowels, leucorrhea with red and white discharge, conjunctival congestion and swelling pain, order is given birth to the nebula film.
Radix Gentianae Macrophyllae: hot, bitter, flat.Return stomach, liver, gallbladder meridian.Wind-damp dispelling, clearing away damp-heat, stopping numbness pain.Be used for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, infantile malnutrition heating.
Radix Paeoniae Rubra: hardship is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.
Semen Plantaginis: sweet, be slightly cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, makes eye bright, and eliminates the phlegm.Be used for the edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
In the present invention in the drug composition with Rhizoma Smilacis Glabrae as monarch drug; Bring into play the effect of its dehumidifying, detoxifcation, easing joint movement, Cortex Fraxini, Radix Gentianae Macrophyllae play the effect of heat clearing and damp drying as ministerial drug; Radix Paeoniae Rubra, Semen Plantaginis make for assistant altogether; Get the effect of its clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, five medicines are harmonious, and play the effect of heat clearing and damp drying, detoxifcation, diuretic, easing joint movement altogether.
Below, foregoing of the present invention is done further to specify through the specific embodiment:
Concrete embodiment
Embodiment 1:
Rhizoma Smilacis Glabrae 30kg, Cortex Fraxini 9kg, Radix Gentianae Macrophyllae 6kg, Radix Paeoniae Rubra 9kg, Semen Plantaginis 12kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds proper honey, evenly mixed, the pill agent.
Embodiment 2:
Rhizoma Smilacis Glabrae 20kg, Cortex Fraxini 9kg, Radix Gentianae Macrophyllae 6kg, Radix Paeoniae Rubra 9kg, Semen Plantaginis 12kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds the 40kg lactose, mixing is used 95% alcohol granulation, and drying incapsulates, and promptly gets capsule.
Embodiment 3:
Rhizoma Smilacis Glabrae 30kg, Cortex Fraxini 12kg, Radix Gentianae Macrophyllae 6kg, Radix Paeoniae Rubra 9kg, Semen Plantaginis 12kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds the 40kg lactose, mixing is granulated, drying, and the adding magnesium stearate is an amount of, mixing, tabletting, coating promptly gets tablet.
Embodiment 4:
Rhizoma Smilacis Glabrae 30kg, Cortex Fraxini 9kg, Radix Gentianae Macrophyllae 9kg, Radix Paeoniae Rubra 9kg, Semen Plantaginis 12kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds proper honey, evenly mixed, the pill agent.
Embodiment 5:
Rhizoma Smilacis Glabrae 30kg, Cortex Fraxini 9kg, Radix Gentianae Macrophyllae 6kg, Radix Paeoniae Rubra 12kg, Semen Plantaginis 12kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds the 40kg lactose, mixing is used 95% alcohol granulation, and drying incapsulates, and promptly gets capsule.
Embodiment 6:
Rhizoma Smilacis Glabrae 30kg, Cortex Fraxini 9kg, Radix Gentianae Macrophyllae 6kg, Radix Paeoniae Rubra 9kg, Semen Plantaginis 15kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds the 40kg lactose, mixing is granulated, drying, and the adding magnesium stearate is an amount of, mixing, tabletting, coating promptly gets tablet.
Embodiment 7:
Rhizoma Smilacis Glabrae 15kg, Cortex Fraxini 9kg, Radix Gentianae Macrophyllae 6kg, Radix Paeoniae Rubra 9kg, Semen Plantaginis 12kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds proper honey, evenly mixed, the pill agent.
Embodiment 8:
Rhizoma Smilacis Glabrae 30kg, Cortex Fraxini 6kg, Radix Gentianae Macrophyllae 6kg, Radix Paeoniae Rubra 9kg, Semen Plantaginis 12kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds the 40kg lactose, mixing is used 95% alcohol granulation, and drying incapsulates, and promptly gets capsule.
Embodiment 9:
Rhizoma Smilacis Glabrae 30kg, Cortex Fraxini 9kg, Radix Gentianae Macrophyllae 3kg, Radix Paeoniae Rubra 9kg, Semen Plantaginis 12kg
Above medical material adds 8 times of amount 70% ethanol extractions, extracts 2 times, and each 1 hour, being concentrated into relative density was the thick paste of 1.30-1.35 (50 ℃), drying under reduced pressure (60 ℃ ,-0.08Mpa), promptly get extract;
Extract is ground into fine powder, adds the 40kg lactose, mixing is granulated, drying, and the adding magnesium stearate is an amount of, mixing, tabletting, coating promptly gets tablet.
Come further to set forth the beneficial effect of pharmaceutical composition according to the invention through following experiment:
The laboratory observation of traditional Chinese medicine composition for treating rat gout model of the present invention
1 materials and methods
1.1 laboratory animal and grouping
30 of Wistar cleaning level male rats, body weight 200-250g is divided into normal group, gout model group and Chinese herb prevention group at random, 10 every group.
1.2 the preparation of urate crystal
With reference to the Seemiller method, uric acid (Uric acid) is dissolved in the NaOH solution of 1mol/L, with HCl adjustment pH, through stirring, filtration, cold drying, screening, sterilize, be prepared into aseptic urate crystal.
1.3 gout Preparation of model
The scorching animal model of experimental uric acid salt ankle joint is made with reference to Coderre TJ and the improvement of Chen Shi method and is carried out.With sterile working's method, with No. 4 injection needles,, inject the articulatio tibiotarsalis intracavity of gout model group and Chinese herb prevention group rat right hind leg internal malleolus with 5% urate solution, 50 μ l, each animal is only injected 1 time.
1.4 medicine
Treatment group rat is raised with Chinese medicine composition medicinal liquid of the present invention, with 10 times of amounts of per kilogram of body weight of people, 4h left and right sides gastric infusion after modeling in the preparation of gout model.Irritate stomach every day 1 time, continuously 3d.Normal group and gout model group rat are irritated isopyknic normal saline.
1.5 observation index
1.5.1 general signs
Observe the outward appearance of rat right hind leg internal malleolus articulatio tibiotarsalis, the active situation of limbs etc.
1.5.2 the K+ concentration of right side ankle joint and surrounding tissue thereof
After modeling the 4th day, the sacrificed by decapitation animal is got hot-tempered joint, right side and surrounding tissue thereof, weighs, homogenate, centrifuging and taking supernatant, with the K+ concentration of the SYNCHRON EL-ISE of U.S. Beckman company analysis-e/or determining tissue.
1.5.3 the tissue pathologies change of right side ankle joint and surrounding tissue thereof
Get right side ankle joint and surrounding tissue thereof, make light microscopic and detect.With conventional method with BIAO and BEN fix, decalcification, paraffin embedding, section, HE dyeing.
2 results
2.1 general signs
Gout model group and treatment rat; After being injected urate solution about the 2nd day (about 24h); The articulatio tibiotarsalis of internal malleolus has occurred all that ankle swelling in various degree, slow, the sufficient pawl of walking are curled, limbs are reluctant to put forth effort to bear a heavy burden, and individual animal hind leg occurs and excessively bows in the wrongly, even walks lamely.After the modeling day, treatment was organized right ankle swelling and is disappeared obviously, various signs on the whole, the gout model group overweights the treatment group.
2.2 the K+ concentration of right side ankle joint and surrounding tissue thereof
The K+ concentration of gout model group ankle joint and surrounding tissue thereof is apparently higher than normal group (p<0.05), and no tangible difference (table 1) between treatment group and the normal group.
The K+ concentration of table 1 ankle joint and surrounding tissue thereof
Figure S2008101132125D00052
Compare * p<0.05 with normal group
2.3 the tissue pathologies change of ankle joint and surrounding tissue thereof
Normal group: ankle joint and structures surrounding thereof are normally clear, do not have any tissue pathologies change.
The gout model group: finding during topography has the urate crystal calmness in the ankle joint intracavity.The visible down significantly arthritis pathology of light microscopic changes; There is tangible foreign body granuloma to form around the tibia shank; Show as the more foreign body multinucleated giant cell of appearance in the foreign body granuloma tissue, newborn little vascularization and more fibroblast, local cartilaginous tissue is destroyed.
Treatment group: the urate crystal calmness is arranged in the ankle joint intracavity.The down visible arthritis pathology of light microscopic changes, and the foreign body multinucleated giant cell is less sees, has newborn little vascularization and the local cartilaginous tissue of less fibroblast that destruction is also arranged.But on the population structure, obviously be better than the gout model group, what have has almost recovered normal.
3 these experimental results of conclusion have been pointed out the treatment of the rat acute gout model that utilization Chinese medicine composition of the present invention is used for being caused by the local injection urate, can obtain comparatively satisfied effect.General signs takes a turn for the better; The PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM that the swelling of ankle joint has the K+ concentration of significantly disappear joint and surrounding tissue thereof obviously to reduce tissue also shows; The pathological change of treatment group arthritis compares with the gout model group, on population structure, improves significantly.Chinese medicine composition of the present invention can the efficacious therapy gout.

Claims (6)

1. a Chinese medicine composition that is used to treat gout is characterized in that, it is to be processed by following bulk drugs: Rhizoma Smilacis Glabrae 15-60 part, Cortex Fraxini 6-12 part, Radix Gentianae Macrophyllae 3-9 part, Radix Paeoniae Rubra 6-12 part, Semen Plantaginis 9-15 part.
2. according to the Chinese medicine composition of claim 1, it is characterized in that it is to be processed by following bulk drugs: 30 parts of Rhizoma Smilacis Glabraes, 9 parts of Cortex Fraxinis, 6 parts of Radix Gentianae Macrophyllae, 9 parts of Radix Paeoniae Rubra, 12 parts of Semen Plantaginiss.
3. the method for preparing of claim 1 or 2 described Chinese medicine compositions is characterized in that, this method is: above medical material adds 8 times of amount 70% ethanol extractions; Extract 2 times, each 1-1.5 hour, the thick paste that to be concentrated into 50 ℃ of relative densities be 1.30-1.35; At 60 ℃, drying under reduced pressure under the-0.08Mpa condition promptly gets extract; Add appropriate amount of auxiliary materials, be prepared into capsule, tablet, pill, drop pill.
4. the method for preparing of Chinese medicine composition according to claim 3 is characterized in that, the method for preparing of pill is: extract is ground into fine powder, adds proper honey, and evenly mixed, the pill agent.
5. the method for preparing of Chinese medicine composition according to claim 3 is characterized in that, the method for preparing of capsule is: extract is ground into fine powder, adds lactose, mixing is used 95% alcohol granulation, and drying incapsulates, and promptly gets capsule.
6. the method for preparing of Chinese medicine composition according to claim 3 is characterized in that, the method for preparing of tablet is: extract is ground into fine powder, adds lactose, mixing is granulated, drying, and the adding magnesium stearate is an amount of, mixing, tabletting, coating promptly gets tablet.
CN2008101132125A 2008-05-27 2008-05-27 Traditional Chinese medicine combination for treating gout and preparation method thereof Active CN101590166B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2008101132125A CN101590166B (en) 2008-05-27 2008-05-27 Traditional Chinese medicine combination for treating gout and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2008101132125A CN101590166B (en) 2008-05-27 2008-05-27 Traditional Chinese medicine combination for treating gout and preparation method thereof

Publications (2)

Publication Number Publication Date
CN101590166A CN101590166A (en) 2009-12-02
CN101590166B true CN101590166B (en) 2012-08-08

Family

ID=41405166

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008101132125A Active CN101590166B (en) 2008-05-27 2008-05-27 Traditional Chinese medicine combination for treating gout and preparation method thereof

Country Status (1)

Country Link
CN (1) CN101590166B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101850063A (en) * 2010-04-02 2010-10-06 贵阳春科药业技术研发有限公司 Medicinal preparation for preventing and treating gout and preparation method
CN108653538A (en) * 2018-07-17 2018-10-16 李开国 A kind of Chinese herbal medicine formula for treating gout
CN110251564B (en) * 2019-07-11 2021-06-29 青岛大学 External medicine for treating gouty arthritis and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1628768A (en) * 2004-08-26 2005-06-22 成都中汇制药有限公司 Medicine for treating gout affection and its symptoms
CN1927330A (en) * 2006-09-05 2007-03-14 广州固志医药科技有限公司 Chinese medicine composition for treating gout and preparing method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1628768A (en) * 2004-08-26 2005-06-22 成都中汇制药有限公司 Medicine for treating gout affection and its symptoms
CN1927330A (en) * 2006-09-05 2007-03-14 广州固志医药科技有限公司 Chinese medicine composition for treating gout and preparing method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
孙光卿.愈痹饮治痛风良效.《江西中医药》.1996,第27卷(第06期), *
尹莲等.四妙丸加味治疗急性痛风性关节炎概述.《中国中医药科技》.2004,第11卷(第01期), *

Also Published As

Publication number Publication date
CN101590166A (en) 2009-12-02

Similar Documents

Publication Publication Date Title
CN101590168B (en) Traditional Chinese medicine combination for treating gout and preparation method thereof
CN101590184B (en) Traditional Chinese medicine combination for treating gout and preparation method thereof
CN100443112C (en) Medicine for treating gout and gout arthritis
CN101062372A (en) Chinese herbal medicine preparation for dissolving hepatobiliary system calculi
CN106266463B (en) Traditional Chinese medicine composition for treating hyperuricemia and application thereof
CN101032593A (en) Acne-treating Chinese medicine preparation
CN101590167B (en) Traditional Chinese medicine combination for treating gout and preparation method thereof
CN101590169B (en) Traditional Chinese medicine combination for treating gout and preparation method thereof
CN101590166B (en) Traditional Chinese medicine combination for treating gout and preparation method thereof
CN102671178A (en) Chinese medicinal composition for treating nephrotic syndrome and uremia and preparation method and application thereof
CN101112533A (en) A Chinese medicinal composition for treating and preventing gout, and its preparation method
CN1840160A (en) Powder for resisting hyperosteogeny
CN107115493A (en) It is a kind of to treat Chinese medicine composition of fracture and its production and use
CN102038778A (en) Chinese medicinal composition with effects of relaxing meridians, activating collaterals, expelling wind and removing dampness and preparation method thereof
CN102091285B (en) Medicinal preparation for clearing heat and restoring consciousness, preparation method thereof and application thereof
CN105106919B (en) A kind of healthy medicated wine and its preparation method and application
CN100534466C (en) Preparation for treating arthritis and preparation method thereof
CN1824103A (en) External use medicine for treating knocks and falls and bone joining
CN104107288A (en) Sinew-relaxing collateral-activating pill
CN106362066A (en) Medicinal liquor for treatment of rheumatic and rheumatoid diseases and preparation method thereof
CN1562116A (en) Chinese medicine preparation with invigorating kidney function
CN110478416A (en) The composition and its preparation method and application for treating rheumatic rheumatoid arthritis
CN114984160B (en) Mongolian medicine for treating alcoholic liver disease
CN112755137B (en) Traditional Chinese medicine composition for treating mild and moderate knee osteoarthritis and application thereof
CN107982409B (en) Traditional Chinese medicine composition and pill for treating syringomyelia and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP01 Change in the name or title of a patent holder

Address after: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003

Patentee after: BEIJING INCREASE PHARMACEUTICAL INSTITUTE Co.,Ltd.

Address before: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003

Patentee before: BEIJING INCREASE PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd.

Address after: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003

Patentee after: BEIJING INCREASE PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd.

Address before: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003

Patentee before: BEIJING INCREASE PHARMACEUTICAL TECHNOLOGY Co.,Ltd.

CP01 Change in the name or title of a patent holder
CP03 Change of name, title or address

Address after: Double camp 102299 West Road Beijing city Changping District Science Park No. 79, No. 24 building 6 layer cloud Valley Park

Patentee after: Beijing Increasepharm Co.,Ltd.

Address before: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003

Patentee before: BEIJING INCREASE PHARMACEUTICAL INSTITUTE Co.,Ltd.

CP03 Change of name, title or address
TR01 Transfer of patent right

Effective date of registration: 20180904

Address after: 519000 room 312-60, 3 / F, aviation and new town planning exhibition hall, Jin Wan District, Zhuhai, Guangdong (central office area)

Patentee after: Ying Kerui (Zhuhai) innovation Pharmaceutical Manufacturing Co.,Ltd.

Address before: 102299 Beijing 6 Changping District science and Technology Park No. 79, No. 24, No.

Patentee before: Beijing Increasepharm Co.,Ltd.

TR01 Transfer of patent right
CP03 Change of name, title or address

Address after: 519090 No. 201, 2nd Floor, South Side of Plant 3#, No. 362, Dingwan 7th Road, Sanzao Town, Jinwan District, Zhuhai City, Guangdong Province

Patentee after: Yingkerui (Zhuhai Jinwan) Pharmaceutical Co.,Ltd.

Address before: 519000 room 312-60, 3 / F, aviation and new town planning exhibition hall, Jin Wan District, Zhuhai, Guangdong (central office area)

Patentee before: Ying Kerui (Zhuhai) innovation Pharmaceutical Manufacturing Co.,Ltd.

CP03 Change of name, title or address
TR01 Transfer of patent right

Effective date of registration: 20230103

Address after: 102299 Room 408 and 409, Floor 4, Building 24, No. 79 Yard, Shuangying West Road, Science Park, Changping District, Beijing

Patentee after: Beijing Baode Runsheng Health Management Co.,Ltd.

Address before: 519090 No. 201, 2nd Floor, South Side of Plant 3#, No. 362, Dingwan 7th Road, Sanzao Town, Jinwan District, Zhuhai City, Guangdong Province

Patentee before: Yingkerui (Zhuhai Jinwan) Pharmaceutical Co.,Ltd.

TR01 Transfer of patent right