CN106729327A - It is a kind of to treat qi-blood deficiency and renal deficiency type irregular menstruation Chinese medicine composition - Google Patents
It is a kind of to treat qi-blood deficiency and renal deficiency type irregular menstruation Chinese medicine composition Download PDFInfo
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Abstract
Qi-blood deficiency and renal deficiency type irregular menstruation Chinese medicine composition is treated the invention discloses a kind of, its raw material composition is：25 35 parts of Radix Codonopsis, 25 35 parts of astragalus root, 10 14 parts of Radix Angelicae Sinensis, 25 35 parts of amethyst, 12 18 parts of cultivated land, 10 14 parts of the root of herbaceous peony, 16 20 parts of mulberries, 10 14 parts of Poria cocos, 10 14 parts of rhizoma atractylodis macrocephalae, 16 20 parts of barrenwort, 16 20 parts of teasel root, 12 18 parts of rhizoma cyperi, 10 14 parts of radix bupleuri, 10 14 parts of Ligusticum wallichii, 10 14 parts of safflower, 16 20 parts of the red sage root, 10 14 parts of dried orange peel, 10 14 parts of the banksia rose, 10 14 parts of fructus amomi, 10 14 parts of the root bark of tree peony, 10 14 parts of embryo nelumbinis, 10 14 parts of the tuber of dwarf lilyturf, 48 parts of honey-fried licorice root.Medicinal material compatibility is suitable selected by Chinese medicine composition of the invention, refining formula, functionally complement each other, for the purpose of nourishing qi and blood, kidney and spleen invigorating, all medicines are used cooperatively, estradiol and follicular stimulating hormone can be promoted to raise, the symptoms, effect is significant such as patient menstrual cycle is disorderly and abnormal colour of menses can be improved；All medicines are mutually made in the property of medicine and are mutually helped, and toxicity is few, take safety.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of to treat qi-blood deficiency and renal deficiency type irregular menstruation Chinese medicine
Composition.
Background technology
Irregular menstruation is common gynecological disease, means menstrual cycle, menstrual period and exception occurs through amount and significant discomfort occurs
The disease of symptom, has a strong impact on and restricts female life and work.The Syndrome Types of TCM of irregular menstruation mainly has：QIXUELIANGXU type,
Blood-cold type, blood-heat type (real heat, abnormal heat), qi stagnation and blood stasis type, renal deficiency type etc., the symptom and therapy of different syndrome type irregular menstruation are equal
It is otherwise varied, wherein, qi-blood deficiency and renal deficiency type irregular menstruation cardinal symptom has：Menstrual cycle is delayed, few through amount, color it is light or
Dim, matter is thin, or under band is clear；Or refreshing tired fatigue and asthenia, underbelly secret anguish, dizzy, palpitation and sleeplessness, pale complexion or wither
It is yellow；Or soreness and weakness of waist and knees, dizziness and tinnitus, complexion is dark dim；Tongue is weak, tongue is thin white, and arteries and veins is thin and delicate.
At present, western medicine mainly adjusts menstrual cycle and ovulation induction with estrogen and progestogen for the treatment of menstrual disorder, side
Case is relatively simple.The traditional Chinese medical science thinks that the main pathogenesis of menstrual disorder are that Exogenous and internal injuries cause body visceral dysfunction, qi and blood entanglement
It is damaged with wantonly two arteries and veins is rushed, organic conception, diagnosis and treatment should be focused in treatment.But in the concrete practice of Chinese traditional treatment irregular menstruation
In, its dialectical viewpoint for treating but differs, and some attention are dialectical from kidney, and irregular menstruation is treated using Kidney-Nourishing；What is had thinks spleen
Stomach is the foundation of acquired constitution, and source of generating QI and blood treats irregular menstruation using Buzhong Yiqi Tang；Also have from the empty opinion of liver and control, be considered as liver
The deficiency of vital energy, liver-yang are empty, 4 aspects of liver blood deficiency and the deficiency of the liver-yin；Also emphasize that the organic conception of the traditional Chinese medical science is controlled from lung opinion, pay attention to a surname's hair of lung
Respectful drop and the relation of qi-blood-body fluid, prescription is carried out according to above-mentioned different treatment thoughts, and its therapeutic effect to irregular menstruation is poor
It is different larger；And lack specific aim for the selection of each bulk drug and the allotment of compatibility relationship in prescription, being mostly simply will tool
The medicine for having the effects such as QI invigorating, blood-nourishing, kidney tonifying, invigorating the spleen is combined, therefore, the curative effect of the Chinese medicine of most for the treatment of irregular menstruations
It is still unsatisfactory, or even some drugs on patients's bodies also have certain side effect.
The content of the invention
For above-mentioned prior art, treat qi-blood deficiency and renal deficiency type irregular menstruation it is an object of the invention to provide a kind of
Chinese medicine composition.
To achieve the above object, the present invention uses following technical proposals：
First aspect present invention, there is provided a kind of to treat qi-blood deficiency and renal deficiency type irregular menstruation Chinese medicine composition, it is former
Expect that composition is：
Radix Codonopsis 25-35 parts, astragalus root 25-35 parts, Radix Angelicae Sinensis 10-14 parts, amethyst 25-35 parts, cultivated land 12-18 parts, the root of herbaceous peony
10-14 parts, mulberries 16-20 parts, Poria cocos 10-14 parts, rhizoma atractylodis macrocephalae 10-14 parts, barrenwort 16-20 parts, teasel root 16-20 parts, rhizoma cyperi
12-18 parts, radix bupleuri 10-14 parts, Ligusticum wallichii 10-14 parts, safflower 10-14 parts, red sage root 16-20 parts, dried orange peel 10-14 parts, banksia rose 10-14
Part, fructus amomi 10-14 parts, root bark of tree peony 10-14 parts, embryo nelumbinis 10-14 parts, tuber of dwarf lilyturf 10-14 parts, honey-fried licorice root 4-8 parts.
Treatment of the invention is qi-blood deficiency and renal deficiency type irregular menstruation Chinese medicine composition, and preferred prescription is：
30 parts of Radix Codonopsis, 30 parts of astragalus root, 12 parts of Radix Angelicae Sinensis, 30 parts of amethyst, 15 parts of cultivated land, 12 parts of the root of herbaceous peony, 18 parts of mulberries, Fu
12 parts of Siberian cocklebur, 12 parts of rhizoma atractylodis macrocephalae, 18 parts of barrenwort, 18 parts of teasel root, 15 parts of rhizoma cyperi, 12 parts of radix bupleuri, 12 parts of Ligusticum wallichii, 12 parts of safflower is red
18 parts of ginseng, 12 parts of dried orange peel, 12 parts of the banksia rose, 12 parts of fructus amomi, 12 parts of the root bark of tree peony, 12 parts of embryo nelumbinis, 12 parts of the tuber of dwarf lilyturf, 6 parts of honey-fried licorice root.
The compatibility mechanism of Chinese medicine composition of the present invention：With Radix Codonopsis, astragalus root, Radix Angelicae Sinensis, amethyst as monarch drug in a prescription, nourishing qi and blood,
Kidney and spleen invigorating.Cultivated land, the root of herbaceous peony, mulberries nourishing yin and nourishing blood, enriching kidney essence；Barrenwort warm kidney sun, the flat tonifying kidney-yin kidney yang of teasel root；Fry white
Art, Poria cocos invigorating the spleen to clear away damp pathogen, all medicines are minister, altogether principal drug assistance；Ligusticum wallichii, safflower, the red sage root, root bark of tree peony nourshing blood and promoting blood circulation menstruation regulating, it is strongly fragrant purify the blood again in
Heat；Rhizoma cyperi, radix bupleuri harmonizing the functional activities of vital QI, make all building up one's health by taking tonic without stagnant；Dried orange peel, the banksia rose, fructus amomi regulating qi-flowing for harmonizing stomach；Embryo nelumbinis mental-tranquilization, closes
Tuber of dwarf lilyturf nourishing Yin and clearing heat, is altogether adjutant；Honey-fried licorice root is to make, coordinating the drug actions of a prescription.
The present invention for qi-blood deficiency and renal deficiency type irregular menstruation carry out it is dialectical treat, kinds of traditional Chinese medicines is carried out into compatibility, medicine
The effect of nourishing qi and blood, kidney and spleen invigorating is played between thing jointly, with obvious synergistic effect, having given full play to mutual reinforcement between mutually makes
Compatibility relationship.
Selected medicinal material compatibility is suitable in side, and refining formula functionally complements each other, and is with nourishing qi and blood, kidney and spleen invigorating
Purpose, all medicines are used cooperatively, and estradiol (E2) and follicular stimulating hormone (FSH) can be promoted to raise, and can improve patient menstrual cycle
The disorderly and symptom, effect is significant such as abnormal colour of menses；All medicines are mutually made in the property of medicine and are mutually helped, and toxicity is few, take safety.
In the Chinese medicine composition of the qi-blood deficiency simultaneous renal deficiency type irregular menstruation for the treatment of of the invention, each raw material components are one to be had
The entirety of machine is indispensable.Inventor has found in R＆D process, reduces any one of above-mentioned composition raw material components,
Or the raw material components of Chinese medicine composition of the present invention are replaced with the bulk drug with the similar property of medicine, then Chinese medicine composition entirety
Action effect significantly reduce；Other raw material components, Chinese traditional medicine composition are further added by the basis of Chinese medicine composition of the invention
The whole structure of thing does not improve significantly, or even the situation for having the whole structure reduction of Chinese medicine composition occurs.
Above-mentioned treatment is qi-blood deficiency and the Chinese medicine composition of renal deficiency type irregular menstruation can be added water to cook, and is made decoction；Also may be used
Prepared with according to other method.In the specific embodiment of the present invention, above-mentioned treatment is qi-blood deficiency and renal deficiency type menstruation
The preparation method of uncomfortable Chinese medicine composition is：
(1) amethyst is decocted 30-40 minutes in marmite；
(2) amethyst and Radix Codonopsis, astragalus root, Radix Angelicae Sinensis, cultivated land, the root of herbaceous peony, mulberries, Poria cocos, rhizoma atractylodis macrocephalae, excessive sheep after decocting
The leaves of pulse plants, teasel root, rhizoma cyperi, radix bupleuri, Ligusticum wallichii, safflower, the red sage root, dried orange peel, the banksia rose, the root bark of tree peony, embryo nelumbinis, the tuber of dwarf lilyturf, honey-fried licorice root mixing, add water pan-fried
Boil and (add 8-10 times for the first time and measure water, decoct 30-60 minutes twice；Second plus 6-8 times measure water, decoct 20-40 minutes), the
Secondary decoction terminates first 5-10 minutes and adds fructus amomi, filters, and merging filtrate is obtained final product.
Traditional Chinese medicine ingredients are complicated, existing water soluble ingredient in a kind of medicinal material, there is oil-soluble or Alcohol soluble composition again, and some are lived
Property composition is easily inactivated at high temperature, therefore Effective Component of Chinese Medicine is carried out by selecting suitable extracting method and extraction process
Extract and separate, can to greatest extent extract active ingredient and ensure the activity of active ingredient, so as to ensure the clinic of product
Effect.
Experiment proves that, using above-mentioned preparation method, can extract to greatest extent in Chinese medicine composition it is effective into
Divide and ensure the activity of active ingredient, so as to ensure the clinical effectiveness of product.For example, for the amethyst in raw material, using " first
Decoct " mode, can strengthen the dissolving of active ingredient, sufficiently achieve saturation capacity；For the fructus amomi in raw material, using " under afterwards "
Mode, the volatilizing loss of active ingredient in fructus amomi can be reduced, its active ingredient is retained in soup to greatest extent.
Application of the above-mentioned Chinese medicine composition in the pharmaceutical preparation for preparing the qi-blood deficiency simultaneous renal deficiency type irregular menstruation for the treatment of
It is the scope of protection of the invention.
Second aspect present invention, there is provided a kind of to treat qi-blood deficiency and renal deficiency type irregular menstruation pharmaceutical preparation, by above-mentioned
Chinese medicine composition and pharmaceutically acceptable auxiliary material are prepared from.
Said medicine preparation can be made various pharmaceutical dosage forms, such as pill, capsule, tablet, powder, granule or oral
Liquid etc..
The pharmaceutically acceptable auxiliary material is the customary adjuvant in pharmaceutical preparation, such as：Disintegrant, lubricant, binder
Deng；One or more preferably in glycerine, butanediol, trehalose, glycine betaine, starch, sodium carboxymethylcellulose.
Effect of Chinese medicine composition of the invention or pharmaceutical preparation：Nourishing qi and blood, kidney and spleen invigorating.Cure mainly qi-blood deficiency and kidney
Asthenic symptoms, card is shown in that the menstrual cycle is delayed, and few through amount, color is light or dim, and matter is thin, or under band is clear；Or refreshing tired fatigue and asthenia, underbelly is hidden
Bitterly, it is dizzy, palpitation and sleeplessness, pale or sallow complexion；Or soreness and weakness of waist and knees, dizziness and tinnitus, complexion is dark dim；Tongue is weak, tongue is thin white,
Arteries and veins is thin and delicate.It is adapted to delayed menstrual cycle, Hypomenorrhea etc., and sees above-mentioned all card persons.
Beneficial effects of the present invention：
Medicinal material compatibility is suitable selected by Chinese medicine composition of the invention, and refining formula functionally complements each other, and is supported with QI invigorating
For the purpose of blood, kidney and spleen invigorating, all medicines are used cooperatively, and estradiol (E2) and follicular stimulating hormone (FSH) can be promoted to raise, and can be improved
Patient's dysmenorrhoea, the confusion of the menstrual cycle and the symptom, effect is significant such as abnormal colour of menses；All medicines are mutually made in the property of medicine and are mutually helped, and poison is secondary anti-
Should lack, take safety.
Specific embodiment
Below by instantiation, the present invention will be further elaborated, it should explanation, the description below be only for
The present invention is explained, its content is not defined.
Embodiment 1：
Formula：30 grams of Radix Codonopsis, 30 grams of astragalus root, 12 grams of Radix Angelicae Sinensis, 30 grams of amethyst, 15 grams of cultivated land, 12 grams of the root of herbaceous peony, mulberries 18
Gram, 12 grams of Poria cocos, 12 grams of rhizoma atractylodis macrocephalae, 18 grams of barrenwort, 18 grams of teasel root, 15 grams of rhizoma cyperi, 12 grams of radix bupleuri, 12 grams of Ligusticum wallichii, safflower 12
Gram, 18 grams of the red sage root, 12 grams of dried orange peel, 12 grams of the banksia rose, 12 grams of fructus amomi, 12 grams of the root bark of tree peony, 12 grams of embryo nelumbinis, 12 grams of the tuber of dwarf lilyturf, honey-fried licorice root 6
Gram.
Preparation method：
(1) amethyst is decocted 35 minutes in marmite；
(2) amethyst and Radix Codonopsis, astragalus root, Radix Angelicae Sinensis, cultivated land, the root of herbaceous peony, mulberries, Poria cocos, rhizoma atractylodis macrocephalae, excessive sheep after decocting
The leaves of pulse plants, teasel root, rhizoma cyperi, radix bupleuri, Ligusticum wallichii, safflower, the red sage root, dried orange peel, the banksia rose, the root bark of tree peony, embryo nelumbinis, the tuber of dwarf lilyturf, honey-fried licorice root mixing, add water pan-fried
Boil and (add 8 times of amount water for the first time, decoct 40 minutes twice；Second plus 8 times of amount water, decoct 30 minutes), decoct knot at second
Add fructus amomi within 5 minutes before beam, filtered after decoction, merging filtrate is obtained final product.
Filtrate after decoction is orally taken, sooner or later twice daily, 10 days as one therapeutic course.
Embodiment 2：
Formula：25 grams of Radix Codonopsis, 35 grams of astragalus root, 10 grams of Radix Angelicae Sinensis, 35 grams of amethyst, 12 grams of cultivated land, 14 grams of the root of herbaceous peony, mulberries 16
Gram, 14 grams of Poria cocos, 10 grams of rhizoma atractylodis macrocephalae, 20 grams of barrenwort, 16 grams of teasel root, 18 grams of rhizoma cyperi, 10 grams of radix bupleuri, 14 grams of Ligusticum wallichii, safflower 10
Gram, 20 grams of the red sage root, 10 grams of dried orange peel, 14 grams of the banksia rose, 10 grams of fructus amomi, 14 grams of the root bark of tree peony, 10 grams of embryo nelumbinis, 14 grams of the tuber of dwarf lilyturf, honey-fried licorice root 4
Gram.
Preparation method and application method are with embodiment 1.
Embodiment 3：
Formula：35 grams of Radix Codonopsis, 25 grams of astragalus root, 14 grams of Radix Angelicae Sinensis, 25 grams of amethyst, 18 grams of cultivated land, 10 grams of the root of herbaceous peony, mulberries 20
Gram, 10 grams of Poria cocos, 14 grams of rhizoma atractylodis macrocephalae, 16 grams of barrenwort, 20 grams of teasel root, 12 grams of rhizoma cyperi, 14 grams of radix bupleuri, 10 grams of Ligusticum wallichii, safflower 14
Gram, 16 grams of the red sage root, 14 grams of dried orange peel, 10 grams of the banksia rose, 14 grams of fructus amomi, 10 grams of the root bark of tree peony, 14 grams of embryo nelumbinis, 10 grams of the tuber of dwarf lilyturf, honey-fried licorice root 8
Gram.
Preparation method and application method are with embodiment 1.
Embodiment 4：
Filtrate after embodiment 1 is decocted is prepared into capsule in conventional manner, and specification is 0.25g/.
Embodiment 5：
Filtrate after embodiment 1 is decocted is prepared into pill in conventional manner.
Embodiment 6：
Filtrate after embodiment 1 is decocted is prepared into granule in conventional manner.
Comparative example 1：
The present inventor the multi-flavor bulk drug with the close property of medicine has been carried out in R＆D process compatibility relationship investigation and
The research of drug effect, as a result finds, even if similar but different from other the bulk drug compatibility of the property of medicine between a few taste bulk drugs makes
With rear, its effect significant difference.For example：Mulberries, fructus amomi, lotus seed kernel and the tuber of dwarf lilyturf in the medicament composing prescription of embodiment 1 are replaced
It is thizoma curculiginis, donkey-hide gelatin, mistletoe, Semen Cuscutae and the fruit of Chinese wolfberry；Consumption and preparation method are with embodiment 1.
Delayed menstrual cycle rat model (menstrual cycle is delayed, few through amount) is set up in conventional manner, investigates the embodiment of the present invention 1
With the Chinese medicine composition of comparative example 1 to the therapeutic effect of irregular menstruation, animal experiment shows, the Chinese medicine group of the embodiment of the present invention 1
The therapeutic effect of compound will be significantly better than comparative example 1.Illustrate that composition of the invention meets the compatibility relationship of Chinese medicine, each group divides it
Between have collaboration facilitation, be not the simple replacement or combination of the bulk drug with the similar property of medicine.
Comparative example 2：
The dose of each bulk drug is the mark efficacy of a drug in Chinese medicine composition, even if the medicine composition of prescription is identical, if but medicine
The consumption of thing is different, and its efficacy of a drug then has dividing for size, and compatibility relationship then has the change of monarch, so that its effect is then
It is each different.The present inventor has carried out investigation and drug effect in R＆D process to the content of each raw material in Chinese medicine composition
Research, as a result finds, the difference of inappropriate raw material proportioning relation, especially monarch drug in a prescription and deal shared by ministerial drug, its effect
Significant difference.For example：The consumption of Radix Codonopsis in embodiment 1 is adjusted to 20 grams, the consumption of astragalus root is adjusted to 40 grams, the use of Radix Angelicae Sinensis
Amount is adjusted to 8 grams, and the consumption of amethyst is adjusted to 20 grams, and the consumption of cultivated land is adjusted to 20 grams, and the consumption of the root of herbaceous peony is adjusted to 8 grams,
The consumption of other raw materials is prepared as described in Example 1 with embodiment 1.
Delayed menstrual cycle rat model (menstrual cycle is delayed, few through amount) is set up in conventional manner, investigates the embodiment of the present invention 1
With the Chinese medicine composition of comparative example 2 to the therapeutic effect of irregular menstruation, animal experiment shows, the Chinese medicine group of the embodiment of the present invention 1
Compound will be significantly better than comparative example 2 to the therapeutic effect of irregular menstruation.Illustrate the consumption of each bulk drug in composition of the invention
It is not that conventional adjustment institute is getable, in Chinese prescription of the invention, the consumption proportion of each raw medicinal material is according to its medicine
What the various Considerations such as material characteristic, monarch compatibility were determined, the overall drug effect for Chinese medicine composition plays extremely important
Effect.
Safety testing：
(1) acute toxicity test：
By the Chinese medicine composition of the embodiment of the present invention 1 with Cmax, maximum volume gastric infusion, continuously given in 24h
Medicine 3 times, per minor tick 4h, accumulation medicine total amount reaches 26g/kg.After administration in 7 days, mouse activity, feed, excretion are normal, raw
Long good, hair color light, its average weight increases with the extension of test period.8d puts to death test mice, carries out system corpse
Inspection and organ coefficient and histological examination, it is as a result without exception, show Chinese medicine composition of the invention without acute toxic reaction.
(2) long term toxicity test：
By the Chinese medicine composition of the embodiment of the present invention 1 be divided into 4.0g (crude drug)/kg/ days, 8.0g (crude drug)/kg/ days and
16.0g (crude drug)/kg/ days three dosage groups, after continuous gavage is administered 2 months, puts to death test mice, determines indices.See
Examine and measure project includes such as outward appearance Signs and behavioral activity, secretion, fecal character；The conventional index and biochemistry of blood refer to
Mark；The content such as system postmortem and organ coefficient and histological examination.
Result shows：Mouse continuous oral is given with various dose, on the food-intake and body weight increase of mouse without influence.It is right
Hepatic and renal function does not find that overt toxicity is acted on；Illustrate Chinese medicine composition safety non-toxic of the invention.
Clinical test：
1. research object
In the May, 2015 of September in 2013 irregular menstruation patient 120 to hospital is chosen, selected patient is divided at random
It is treatment group and control group, every group 60.Age, course of disease for the treatment of group and control group etc. are without significant (p ＞ 0.05), tool
There is comparativity.
2. diagnostic criteria：According to《Chinese medical disease Standardization of diagnosis and curative effect》(State Administration of Traditional Chinese Medicine) formulates, diagnostic criteria
It is as follows：
(1) continuous 2 more than the menstrual cycle more than 35 days the menstrual cycle；
(2) women of child-bearing age delay in the cycle, should mutually differentiate with gestation, puberty, climacteric menstruation later stage；
(3) gynecologial examination, B ultrasonic or pneumoperitoneography, to exclude uterus and ovary organic disease.
3. treatment method：
Decoction prepared by the oral embodiment of the present invention 1 for the treatment of group, twice daily, 10 days as one therapeutic course.
The oral gynecologic rehabilitation capsules of control group, by specification is taken, 10 days as one therapeutic course.
It is continuous to take 3 courses for the treatment of, the treatment of two groups of observation, and carry out statistical analysis.
4. criterion of therapeutical effect：According to《Chinese medical disease Standardization of diagnosis and curative effect》(State Administration of Traditional Chinese Medicine) formulates, specific as follows：
(1) cure：Menstrual cycle recovers normal, maintains more than 3 months.
(2) take a turn for the better：Menstrual cycle recovers normal, but can not maintain more than 3 months.
(3) do not heal：Menstrual cycle does not improve.
5. result：
Treatment results are shown in Table 1.
Table 1：Treatment results
Through X2Inspection, compares with control group, and treatment group significantly improves (P to the treatment total effective rate of irregular menstruation<0.05),
Have no adverse reaction example in therapeutic process.Illustrate that there is Chinese medicine composition of the invention good clinical treatment to imitate to irregular menstruation
Really, and safe without toxic side effect.
Model case：
Case 1：Lee, female, 26 years old.The past menstruation rule, January a line, nearly in menstrual cycle, 3 is delayed, the 2-3 months one
OK, few through amount, color is light or dim, and matter is thin, and with underbelly secret anguish is seen, dizzy, palpitation and sleeplessness, pale complexion, tongue is weak, tongue is thin
In vain, arteries and veins is thin and delicate.It is diagnosed as：Delayed menstrual cycle, Hypomenorrhea.It is dialectical for qi-blood deficiency, kidney qi is weak；Therapy：Nourishing qi and blood, kidney tonifying
Invigorating the spleen.Take 1 course for the treatment of of Chinese medicine composition (decoction) of the embodiment of the present invention 1, menstrual period, through measuring normal, underbelly secret anguish, head
The symptoms such as dizzy dim eyesight, palpitation and sleeplessness disappear substantially；1 course for the treatment of is continued to strengthen, all symptoms disappear, the menstrual cycle recovers normal,
Cure.6 months no relapse of follow-up.
Case 2：Wang, female, 28 years old.The first visit of in April, 2014.The past menstruation rule, now continuous 4 menstrual cycles delay 7
It or so, is reduced with through amount, and color is light red, usually spiritlessness and weakness, is defecated shapeless.Give the decoction 1 of the preparation of the embodiment of the present invention 1
The individual course for the treatment of, its symptom is relieved, and after continuing to strengthen 1 course for the treatment of, the menstrual cycle recovers normal, is obviously improved earlier above through amount.Suffer from
Person's private prosecution is without any side effects during taking medicine.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
It is any to be familiar with those skilled in the art in the technical scope of present disclosure, technology according to the present invention scheme and its invention
Design is subject to equivalent or change, should all be included within the scope of the present invention.
Claims (8)
1. it is a kind of to treat qi-blood deficiency and renal deficiency type irregular menstruation Chinese medicine composition, it is characterised in that its raw material constitutes and is：
Radix Codonopsis 25-35 parts, astragalus root 25-35 parts, Radix Angelicae Sinensis 10-14 parts, amethyst 25-35 parts, cultivated land 12-18 parts, root of herbaceous peony 10-14
Part, mulberries 16-20 parts, Poria cocos 10-14 parts, rhizoma atractylodis macrocephalae 10-14 parts, barrenwort 16-20 parts, teasel root 16-20 parts, rhizoma cyperi 12-18
Part, radix bupleuri 10-14 parts, Ligusticum wallichii 10-14 parts, safflower 10-14 parts, red sage root 16-20 parts, dried orange peel 10-14 parts, banksia rose 10-14 parts, sand
Benevolence 10-14 parts, root bark of tree peony 10-14 parts, embryo nelumbinis 10-14 parts, tuber of dwarf lilyturf 10-14 parts, honey-fried licorice root 4-8 parts.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that its raw material composition is：
30 parts of Radix Codonopsis, 30 parts of astragalus root, 12 parts of Radix Angelicae Sinensis, 30 parts of amethyst, 15 parts of cultivated land, 12 parts of the root of herbaceous peony, 18 parts of mulberries, Poria cocos 12
Part, 12 parts of rhizoma atractylodis macrocephalae, 18 parts of barrenwort, 18 parts of teasel root, 15 parts of rhizoma cyperi, 12 parts of radix bupleuri, 12 parts of Ligusticum wallichii, 12 parts of safflower, the red sage root 18
Part, 12 parts of dried orange peel, 12 parts of the banksia rose, 12 parts of fructus amomi, 12 parts of the root bark of tree peony, 12 parts of embryo nelumbinis, 12 parts of the tuber of dwarf lilyturf, 6 parts of honey-fried licorice root.
3. the preparation method of the Chinese medicine composition described in claim 1 or 2, it is characterised in that step is as follows：
(1) amethyst is decocted 30-40 minutes in marmite；
(2) it is amethyst and Radix Codonopsis, astragalus root, Radix Angelicae Sinensis, cultivated land, the root of herbaceous peony, mulberries, Poria cocos, rhizoma atractylodis macrocephalae, barrenwort after decocting, continuous
Disconnected, rhizoma cyperi, radix bupleuri, Ligusticum wallichii, safflower, the red sage root, dried orange peel, the banksia rose, the root bark of tree peony, embryo nelumbinis, the tuber of dwarf lilyturf, honey-fried licorice root mixing, add water to cook two
It is secondary, add fructus amomi within 5-10 minutes before second decoction terminates, filter, merging filtrate is obtained final product.
4. preparation method as claimed in claim 3, it is characterised in that the concrete operations that decocting is boiled are：Add 8-10 times for the first time
Amount water, decocts 30-60 minutes；Add 6-8 times for second and measure water, decoct 20-40 minutes.
5. the Chinese medicine composition described in claim 1 or 2 is preparing the medicine system of the qi-blood deficiency simultaneous renal deficiency type irregular menstruation for the treatment of
Purposes in agent.
6. it is a kind of to treat qi-blood deficiency and renal deficiency type irregular menstruation pharmaceutical preparation, the Chinese traditional medicine composition as described in claim 1 or 2
Thing and pharmaceutically acceptable auxiliary material are prepared from.
7. pharmaceutical preparation as claimed in claim 6, it is characterised in that the pharmaceutically acceptable auxiliary material is disintegrant, profit
Lubrication prescription or binder.
8. pharmaceutical preparation as claimed in claim 6, it is characterised in that the formulation of the pharmaceutical preparation is pill, capsule, piece
Agent, powder, granule or oral liquid.
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| CN114432410A (en) * | 2021-12-28 | 2022-05-06 | 上海中医药大学附属曙光医院 | Blood-activating and stasis-removing ointment formula and application thereof |
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| 徐勤都等: ""刘瑞芬辨治月经后期导致不孕的经验"", 《甘肃中医学院学报》 * |
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| CN114432410A (en) * | 2021-12-28 | 2022-05-06 | 上海中医药大学附属曙光医院 | Blood-activating and stasis-removing ointment formula and application thereof |
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