CN101934052B - Medicament for treating facial chloasma and preparation method thereof - Google Patents

Medicament for treating facial chloasma and preparation method thereof Download PDF

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CN101934052B
CN101934052B CN2010102762302A CN201010276230A CN101934052B CN 101934052 B CN101934052 B CN 101934052B CN 2010102762302 A CN2010102762302 A CN 2010102762302A CN 201010276230 A CN201010276230 A CN 201010276230A CN 101934052 B CN101934052 B CN 101934052B
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radix
rhizoma
fructus
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CN101934052A (en
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魏玮
刘冰
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Abstract

The invention discloses a medicament for treating facial chloasma and a preparation method thereof. The medicament is prepared from the following medicinal raw materials in part by weight: 15 to 25 parts of mulberry leaf, 15 to 30 parts of chrysanthemum, 15 to 25 parts of mongolian snakegourd root, 10 to 20 parts of manyleaf paris rhizome, 15 to 25 parts of purpleflower holly leaf, 15 to 25 parts of root of rehmannia, 15 to 25 parts of cortex moutan, 15 to 25 parts of red paeony root, 15 to 25 parts of sinkiang arnebia root, 15 to 25 parts of beautiful sweetgum fruit, 5 to 25 parts of ricepaper pith, 20 to 30 parts of Indian Buead, 10 to 25 parts of giant typhonium rhizome, 10 to 25 parts of bletilla, 15 to 50 parts of angelica dahurica, 12 to 30 parts of nutgrass galingale rhizome, 10 to 20 parts of szechuan lovage rhizome, 20 to 50 parts of motherwort herb, 10 to 25 parts of Chinese angelica, 15 to 30 parts of white paeony root, 30 to 60 parts of yam, 20 to 50 parts of coix seed, 12 to 30 parts of citron, 12 to 30 parts of fingered citron, 10 to 20 parts of common burreed rhizome, 10 to 20 parts of zedoary, 15 to 50 parts of glossy privet fruit, 15 to 50 parts of eclipta, 15 to 50 parts of malaytea scurfpea fruit, 15 to 50 parts of cornus, 15 to 30 parts of peach seed, 15 to 30 parts of cowherb seed, 20 to 40 parts of Chinese trumpet creeper, 30 to 50 parts of rose and 0.5 to 2 parts of pseudoginseng root powder. The medicament has the advantages of low cost, readily available raw materials, obvious efficacy and no toxic or side effect.

Description

A kind of medicine for the treatment of chloasma faciei and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of chloasma faciei and preparation method thereof.
Background technology
Chloasma faciei is more common in the women, and it is relevant with the endocrine function imbalance that modern medicine is thought.The position of disease is many in the cheekbone both sides, is butterfly-shaped or lamellar is distributed in face, thus claim butterfly spot again, its clear border, NIP, yellowish, yellowish-brown or black, symptoms such as no sufferings, but influence the attractive in appearance of appearance, easily cause the misery on the female mental.
Summary of the invention
The purpose of this invention is to provide a kind of cheap, draw materials conveniently, effect significantly, the medicine of the treatment chloasma faciei that has no side effect and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of medicine for the treatment of chloasma faciei is characterized in that: made by following Chinese herb raw materials by weight:
Folium Mori 15~25; Flos Chrysanthemi 15~30; Radix Trichosanthis 15~25; Rhizoma Paridis 10~20; Ilex purpurea Hassk.[I.chinensis Sims 15~25; The Radix Rehmanniae 15~25; Cortex Moutan 15~25; Radix Paeoniae Rubra 15~25; Radix Arnebiae (Radix Lithospermi) 15~25; Fructus Liquidambaris 15~25; Medulla Tetrapanacis 5~25; Poria 20~30; Rhizoma Typhonii 10~25; The Pseudobulbus Bletillae (Rhizoma Bletillae) 10~25; The Radix Angelicae Dahuricae 15~50; Rhizoma Cyperi 12~30; Rhizoma Chuanxiong 10~20; Herba Leonuri 20~50; Radix Angelicae Sinensis 10~25; The Radix Paeoniae Alba 15~30; Rhizoma Dioscoreae 30~60; Semen Coicis 20~50; Fructus Citri 12~30; Fructus Citri Sarcodactylis 12~30; Rhizoma sparganic 10~20; Rhizoma Curcumae 10~20; Fructus Ligustri Lucidi 15~50; Herba Ecliptae 15~50; Fructus Psoraleae 15~50; Fructus Corni 15~50; Semen Persicae 15~30; Semen Vaccariae 15~30; Flos Campsis 20~40; Flos Rosae Rugosae 30~50; Radix Notoginseng powder 0.5~2.
Medicine according to described treatment chloasma faciei is characterized in that: made by following Chinese herb raw materials by weight:
Folium Mori 20; Flos Chrysanthemi 20; Radix Trichosanthis 20; Rhizoma Paridis 15; Ilex purpurea Hassk.[I.chinensis Sims 20; The Radix Rehmanniae 20; Cortex Moutan 20; Radix Paeoniae Rubra 20; Radix Arnebiae (Radix Lithospermi) 20; Fructus Liquidambaris 20; Medulla Tetrapanacis 20; Poria 25; Rhizoma Typhonii 20; The Pseudobulbus Bletillae (Rhizoma Bletillae) 20; The Radix Angelicae Dahuricae 40; Rhizoma Cyperi 20; Rhizoma Chuanxiong 15; Herba Leonuri 35; Radix Angelicae Sinensis 20; The Radix Paeoniae Alba 20; Rhizoma Dioscoreae 50; Semen Coicis 30; Fructus Citri 20; Fructus Citri Sarcodactylis 20; Rhizoma sparganic 15; Rhizoma Curcumae 15; Fructus Ligustri Lucidi 40, Herba Ecliptae 40; Fructus Psoraleae 40; Fructus Corni 40; Semen Persicae 20; Semen Vaccariae 20; Flos Campsis 30; Flos Rosae Rugosae 30; Radix Notoginseng powder 1.
Medicine according to described treatment chloasma faciei is characterized in that: made by following Chinese herb raw materials by weight:
Folium Mori 25; Flos Chrysanthemi 30; Radix Trichosanthis 25; Rhizoma Paridis 20; Ilex purpurea Hassk.[I.chinensis Sims 25; The Radix Rehmanniae 25; Cortex Moutan 25; Radix Paeoniae Rubra 25; Radix Arnebiae (Radix Lithospermi) 25; Fructus Liquidambaris 25; Medulla Tetrapanacis 25; Poria 30; Rhizoma Typhonii 25; The Pseudobulbus Bletillae (Rhizoma Bletillae) 25; The Radix Angelicae Dahuricae 50; Rhizoma Cyperi 30; Rhizoma Chuanxiong 20; Herba Leonuri 50; Radix Angelicae Sinensis 25; The Radix Paeoniae Alba 30; Rhizoma Dioscoreae 60; Semen Coicis 50; Fructus Citri 30; Fructus Citri Sarcodactylis 30; Rhizoma sparganic 20; Rhizoma Curcumae 20; Fructus Ligustri Lucidi 50, Herba Ecliptae 50; Fructus Psoraleae 50; Fructus Corni 50; Semen Persicae 30; Semen Vaccariae 30; Flos Campsis 40; Flos Rosae Rugosae 40; Radix Notoginseng powder 2.
Medicine according to described treatment chloasma faciei is characterized in that: made by following Chinese herb raw materials by weight:
Folium Mori 15; Flos Chrysanthemi 15; Radix Trichosanthis 15; Rhizoma Paridis 10; Ilex purpurea Hassk.[I.chinensis Sims 15; The Radix Rehmanniae 15; Cortex Moutan 15; Radix Paeoniae Rubra 15; Radix Arnebiae (Radix Lithospermi) 15; Fructus Liquidambaris 15; Medulla Tetrapanacis 5; Poria 20; Rhizoma Typhonii 10; The Pseudobulbus Bletillae (Rhizoma Bletillae) 10; The Radix Angelicae Dahuricae 15; Rhizoma Cyperi 12; Rhizoma Chuanxiong 10; Herba Leonuri 20; Radix Angelicae Sinensis 15; The Radix Paeoniae Alba 15; Rhizoma Dioscoreae 30; Semen Coicis 20; Fructus Citri 12; Fructus Citri Sarcodactylis 12; Rhizoma sparganic 10; Rhizoma Curcumae 10; Fructus Ligustri Lucidi 15, Herba Ecliptae 15; Fructus Psoraleae 15; Fructus Corni 15; Semen Persicae 15; Semen Vaccariae 15; Flos Campsis 20; Flos Rosae Rugosae 30; Radix Notoginseng powder 0.5.
Medicine according to described treatment chloasma faciei is characterized in that: made by following Chinese herb raw materials by weight:
Folium Mori 15; Flos Chrysanthemi 15; Radix Trichosanthis 20; Rhizoma Paridis 15; Ilex purpurea Hassk.[I.chinensis Sims 15; The Radix Rehmanniae 20; Cortex Moutan 15; Radix Paeoniae Rubra 20; Radix Arnebiae (Radix Lithospermi) 20; Fructus Liquidambaris 20; Medulla Tetrapanacis 10; Poria 20; Rhizoma Typhonii 20; The Pseudobulbus Bletillae (Rhizoma Bletillae) 10; The Radix Angelicae Dahuricae 20; Rhizoma Cyperi 15; Rhizoma Chuanxiong 15; Herba Leonuri 25; Radix Angelicae Sinensis 15; The Radix Paeoniae Alba 15; Rhizoma Dioscoreae 40; Semen Coicis 25; Fructus Citri 15; Fructus Citri Sarcodactylis 20; Rhizoma sparganic 15; Rhizoma Curcumae 15; Fructus Ligustri Lucidi 30, Herba Ecliptae 40; Fructus Psoraleae 25; Fructus Corni 30; Semen Persicae 20; Semen Vaccariae 15; Flos Campsis 25; Flos Rosae Rugosae 30; Radix Notoginseng powder 1.5.
A kind of method for preparing described treatment chloasma faciei medicine is characterized in that: according to described medicine material parts by weight, except the Radix Notoginseng powder, put into marmite, add cold water 800 weight portions, soaked 1 hour, after big fire was fried in shallow oil out, little fire was fried in shallow oil 15~20 minutes; Medicine juice is poured in the ready glass container; The medicine in the marmite is added cold water 300 weight portions, as above method is fried again, and medicine juice was poured into again in the glass container and mixed after secondary was boiled medicine, and twice admixing medical solutions 500 weight portion adds Radix Notoginseng powder 1 weight portion.
The present invention is on the basis of clinical treatment experience for many years, in conjunction with latest modern technological pharmacological research achievement, confirms repeatedly through clinical, and formulation science, effect is remarkable, has no side effect.30 Chinese medicine of the five flavours are learnt from other's strong points to offset one's weaknesses among the present invention, and complementation is held up mutually, and combined effect is in liver, spleen and face.Medicine of the present invention not only has the soothing the liver reason spleen of heat clearing away collateral dredging, the blood circulation promoting and blood stasis dispelling regulating menstruation, and effects such as the kidney invigorating speckle removing, and practical value height, cheap, draw materials conveniently, simple for production.The present invention treats chloasma faciei unique significant curative effect.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment:
Embodiment 1 (most preferred embodiment):
A kind of medicine for the treatment of chloasma faciei of the present invention is made by the medicine material of following weight:
Folium Mori 20g; Flos Chrysanthemi 20g; Radix Trichosanthis 20g; Rhizoma Paridis 15g; Ilex purpurea Hassk.[I.chinensis Sims 20g; Radix Rehmanniae 20g; Cortex Moutan 20g; Radix Paeoniae Rubra 20g; Radix Arnebiae (Radix Lithospermi) 20g; Fructus Liquidambaris 20g; Medulla Tetrapanacis 20g; Poria 25g; Rhizoma Typhonii 20g; Pseudobulbus Bletillae (Rhizoma Bletillae) 20g; Radix Angelicae Dahuricae 40g; Rhizoma Cyperi 20g; Rhizoma Chuanxiong 15g; Herba Leonuri 35g; Radix Angelicae Sinensis 20g; Radix Paeoniae Alba 20g; Rhizoma Dioscoreae 50g; Semen Coicis 30g; Fructus Citri 20g; Fructus Citri Sarcodactylis 20g; Rhizoma sparganic 15g; Rhizoma Curcumae 15g; Fructus Ligustri Lucidi 40g, Herba Ecliptae 40g; Fructus Psoraleae 40g; Fructus Corni 40g; Semen Persicae 20g; Semen Vaccariae 20g; Flos Campsis 30g; Flos Rosae Rugosae 30g; Radix Notoginseng powder 1g.
The present invention treats the preparation method and the drug use method of chloasma faciei medicine:
Folium Mori 20g will be placed earlier in the marmite; Flos Chrysanthemi 20g; Radix Trichosanthis 20g; Rhizoma Paridis 15g; Ilex purpurea Hassk.[I.chinensis Sims 20g; Radix Rehmanniae 20g; Cortex Moutan 20g; Radix Paeoniae Rubra 20g; Radix Arnebiae (Radix Lithospermi) 20g; Fructus Liquidambaris 20g; Medulla Tetrapanacis 20g; Poria 25g; Rhizoma Typhonii 20g; Pseudobulbus Bletillae (Rhizoma Bletillae) 20g; Radix Angelicae Dahuricae 40g; Rhizoma Cyperi 20g; Rhizoma Chuanxiong 15g; Herba Leonuri 35g; Radix Angelicae Sinensis 20g; Radix Paeoniae Alba 20g; Rhizoma Dioscoreae 50g; Semen Coicis 30g; Fructus Citri 20g; Fructus Citri Sarcodactylis 20g; Rhizoma sparganic 15g; Rhizoma Curcumae 15g; Fructus Ligustri Lucidi 40g, Herba Ecliptae 40g; Fructus Psoraleae 40g; Fructus Corni 40g; Semen Persicae 20g; Semen Vaccariae 20g; Flos Campsis 30g; Flos Rosae Rugosae 30g.
Add the about 800ml of cold water, soaked 1 hour, after big fire was fried in shallow oil out, little fire was fried in shallow oil 15~20 minutes.Medicine juice is poured in the ready glass container.Again the medicine in the marmite is added cold water 300ml, as above method is fried, and the secondary back medicine juice of boiling medicine is poured into again in the glass container and mixed, twice about 500ml of admixing medical solutions, divide 2 times oral.Need before taking medicine with medicine warm after, take after adding Radix Notoginseng powder 1g.Potion on the one, serveing on 15 is a course of treatment.Medicine juice is poured in the washbasin in the residue marmite, medicine juice is applied face after clean, stops 15~20 minutes.
The present invention puts into marmite with medicine, take Folium Mori, Flos Chrysanthemi, Radix Trichosanthis, Rhizoma Paridis, Ilex purpurea Hassk.[I.chinensis Sims, the Radix Rehmanniae, Cortex Moutan, Radix Paeoniae Rubra, Radix Arnebiae (Radix Lithospermi), Fructus Liquidambaris, Medulla Tetrapanacis, Poria, Rhizoma Typhonii, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Rhizoma Cyperi, Rhizoma Chuanxiong, Herba Leonuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Semen Coicis, Fructus Citri, Fructus Citri Sarcodactylis, rhizoma sparganic, Rhizoma Curcumae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Psoraleae, Fructus Corni, Semen Persicae, Semen Vaccariae, Flos Campsis, the effective ingredient of Flos Rosae Rugosae, put into behind the Radix Notoginseng powder oral again, the external application again of residue medicine juice, 30 Chinese medicine of the five flavours are learnt from other's strong points to offset one's weaknesses, complementation is held up mutually, and combined effect is in liver, spleen and face.This agent medicine has the soothing the liver reason spleen of heat clearing away collateral dredging, blood circulation promoting and blood stasis dispelling regulating menstruation, the kidney invigorating speckle removing effect.The present invention treats chloasma faciei unique significant curative effect.
The side separates:
Folium Mori, Flos Chrysanthemi, Radix Trichosanthis, Rhizoma Paridis, Ilex purpurea Hassk.[I.chinensis Sims: heat-clearing and toxic substances removing, moisturize.
The Radix Rehmanniae, Cortex Moutan, Radix Paeoniae Rubra, Radix Arnebiae (Radix Lithospermi), Fructus Liquidambaris: clearing away heat and cooling blood, invigorate blood circulation collateral dredging.
Poria, Rhizoma Dioscoreae, Semen Coicis, Rhizoma Typhonii, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, the Radix Angelicae Dahuricae: spleen invigorating, warming the meridian, collateral dredging, regulating menstruation, speckle removing.
Rhizoma sparganic, Rhizoma Curcumae: invigorate blood circulation blood stasis dispelling, collateral dredging.
Rhizoma Cyperi, Rhizoma Chuanxiong, Herba Leonuri, Radix Angelicae Sinensis, Medulla Tetrapanacis: invigorate blood circulation, soothing the liver regulating menstruation collateral dredging, blood stasis dispelling.
Fructus Citri, Fructus Citri Sarcodactylis, Semen Persicae, Semen Vaccariae: invigorating spleen to remove dampness, collateral dredging regulating menstruation, blood stasis dispelling.
Radix Notoginseng: blood circulation promoting and blood stasis dispelling.
Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Psoraleae, Fructus Corni: the kidney invigorating collateral dredging.
Flos Campsis, Flos Rosae Rugosae: blood circulation promoting and blood stasis dispelling, speckle removing.
Embodiment 2:
A kind of medicine for the treatment of chloasma faciei of the present invention is made by the medicine material of following weight:
Folium Mori 25g; Flos Chrysanthemi 30g; Radix Trichosanthis 25g; Rhizoma Paridis 20g; Ilex purpurea Hassk.[I.chinensis Sims 25g; Radix Rehmanniae 25g; Cortex Moutan 25g; Radix Paeoniae Rubra 25g; Radix Arnebiae (Radix Lithospermi) 25g; Fructus Liquidambaris 25g; Medulla Tetrapanacis 25g; Poria 30g; Rhizoma Typhonii 25g; Pseudobulbus Bletillae (Rhizoma Bletillae) 25g; Radix Angelicae Dahuricae 50g; Rhizoma Cyperi 30g; Rhizoma Chuanxiong 20g; Herba Leonuri 50g; Radix Angelicae Sinensis 25g; Radix Paeoniae Alba 30g; Rhizoma Dioscoreae 60g; Semen Coicis 50g; Fructus Citri 30g; Fructus Citri Sarcodactylis 30g; Rhizoma sparganic 20g; Rhizoma Curcumae 20g; Fructus Ligustri Lucidi 50g, Herba Ecliptae 50g; Fructus Psoraleae 50g; Fructus Corni 50g; Semen Persicae 30g; Semen Vaccariae 30g; Flos Campsis 40g; Flos Rosae Rugosae 40g; Radix Notoginseng powder 2g.
Present embodiment Chinese herbal medicine dosage is excessive, and stomach discomfort behind general patient's oral drugs has symptom of diarrhea.Behind patient's external application face, scorching hot sense of discomfort is arranged.
Embodiment 3:
A kind of medicine for the treatment of chloasma faciei of the present invention is made by the medicine material of following weight:
Folium Mori 15g; Flos Chrysanthemi 15g; Radix Trichosanthis 15g; Rhizoma Paridis 10g; Ilex purpurea Hassk.[I.chinensis Sims 15g; Radix Rehmanniae 15g; Cortex Moutan 15g; Radix Paeoniae Rubra 15g; Radix Arnebiae (Radix Lithospermi) 15g; Fructus Liquidambaris 15g; Medulla Tetrapanacis 5g; Poria 20g; Rhizoma Typhonii 10g; Pseudobulbus Bletillae (Rhizoma Bletillae) 10g; Radix Angelicae Dahuricae 15g; Rhizoma Cyperi 12g; Rhizoma Chuanxiong 10g; Herba Leonuri 20g; Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Dioscoreae 30g; Semen Coicis 20g; Fructus Citri 12g; Fructus Citri Sarcodactylis 12g; Rhizoma sparganic 10g; Rhizoma Curcumae 10g; Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g; Fructus Psoraleae 15g; Fructus Corni 15g; Semen Persicae 15g; Semen Vaccariae 15g; Flos Campsis 20g; Flos Rosae Rugosae 30g; Radix Notoginseng powder 0.5g.
Present embodiment Chinese herbal medicine dosage is less, and the course of treatment is longer, and effect is relatively poor.
Embodiment 4:
A kind of medicine for the treatment of chloasma faciei of the present invention is made by the medicine material of following weight:
Folium Mori 15g; Flos Chrysanthemi 15g; Radix Trichosanthis 20g; Rhizoma Paridis 15g; Ilex purpurea Hassk.[I.chinensis Sims 15g; Radix Rehmanniae 20g; Cortex Moutan 15g; Radix Paeoniae Rubra 20g; Radix Arnebiae (Radix Lithospermi) 20g; Fructus Liquidambaris 20g; Medulla Tetrapanacis 10g; Poria 20g; Rhizoma Typhonii 20g; Pseudobulbus Bletillae (Rhizoma Bletillae) 10g; Radix Angelicae Dahuricae 20g; Rhizoma Cyperi 15g; Rhizoma Chuanxiong 15g; Herba Leonuri 25g; Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Dioscoreae 40g; Semen Coicis 25g; Fructus Citri 15g; Fructus Citri Sarcodactylis 20g; Rhizoma sparganic 15g; Rhizoma Curcumae 15g; Fructus Ligustri Lucidi 30g, Herba Ecliptae 40g; Fructus Psoraleae 25g; Fructus Corni 30g; Semen Persicae 20g; Semen Vaccariae 15g; Flos Campsis 25g; Flos Rosae Rugosae 30g; Radix Notoginseng powder 1.5g.
Present embodiment dosage is moderate relatively, but mouthfeel is bitter, and effect is not as embodiment 1.
Pharmacodynamic experiment report (drug component with embodiment 1 is treated):
Physical data:
Get outpatient service 200 examples, divide treatment group and matched group at random.100 examples are organized in treatment, and at minimum 22 years old of age, maximum 47 years old, the course of disease was the shortest 3 months, elder 6 years.Workman's 40 examples, peasant's 42 examples, cadre's 18 examples.
Matched group 100 examples, minimum 25 years old of age, the maximum 45 years old.The course of disease is the shortest 6 months, elder 4 years.Workman's 42 examples, peasant's 44 examples, cadre's 14 examples.
Two groups of ages, occupation, course of disease situations compare, and two groups of data are learned processing (P>0.05) by statistics, and no significant difference has comparability.
Diagnostic criteria
1, chloasma faciei betides middle-aged women well.
2, the position of disease is many in the cheekbone both sides, is butterfly-shaped or lamellar is distributed in face, so woman's title butterfly spot.
3, its clear border, NIP, yellowish, yellowish-brown or black, symptom such as painless, as to itch, but influence the attractive in appearance of appearance, easily cause the misery on the female mental.
Therapeutic Method: the treatment group is taken course of treatment of the present invention, observe the curative effect, the oral PAIDU YANGYAN JIAONANG of matched group (the accurate word Z53020685 of traditional Chinese medicines), composition has Radix Et Rhizoma Rhei, Radix Panacis Quinquefolii, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng Rubra, Folium Nelumbinis, Fructus Aurantii Immaturus etc., 3 times on the one, one time 2,15 is a course of treatment, one the course of treatment observe the curative effect.
Therapeutic outcome:
Two groups of chloasma faciei patients observe through a course of therapy, the results are shown in Table:
Table 1 liang group curative effect is than imitating
Figure BSA00000262261700061
Annotate: X 2=67.6P, P<0.01, first course of therapy, two groups of curative effects have highly significant difference.
Use the present invention and treat chloasma faciei 100 examples,, cure 78 examples through 1 course of therapy, 20 examples that take a turn for the better, invalid 2 examples, cure rate 78%, total effective rate 98% is learned by statistics and is handled (X 2Check), treatment group curative effect is apparently higher than matched group (P<0.01).
Through observing 2 courses of treatment, the results are shown in Table 2.
Table 2 liang group curative effect relatively
Figure BSA00000262261700062
Annotate: X 2=77.61P, P<0.01, treat second course of treatment after two groups of curative effects highly significant difference is relatively arranged.
Observe through the 2nd course of therapy, total 94 examples of curing of treatment group, 4 examples that take a turn for the better, cure rate 94%, total effective rate 98% is learned by statistics and is handled (X 2Check), treatment group curative effect is apparently higher than matched group (P<0.01).
The present invention treats the analysis of facial brown spot clinical practice social benefit
Chloasma, good sending out in middle-aged women, the position of disease is many in the cheekbone both sides, is butterfly-shaped or lamellar is distributed in face, so claim butterfly spot again.Its clear border, NIP, yellowish, yellowish-brown or black, symptom such as painless, as to itch, but influence the attractive in appearance of appearance, easily cause the misery on the female mental.Therefore, research treatment chloasma faciei has efficiently, safely, the prescription preparation that has no side effect, to remove women's misery, satisfying the clinical treatment demand has very important meaning.
The present invention is on the basis of clinical treatment experience for many years, in conjunction with latest modern technological pharmacological research achievement, confirms repeatedly through clinical, formulation science, effect is remarkable, has no side effect, and the soothing the liver reason spleen of heat clearing away collateral dredging is not only arranged, the blood circulation promoting and blood stasis dispelling regulating menstruation, effects such as the kidney invigorating speckle removing, and practical value height, cheap, draw materials conveniently, simple for production.
Use the present invention and treat chloasma faciei patient 212 examples, minimum 22 years old of age, the maximum 47 years old, and 212 routine patients are carried out follow-up investigation, and clinical cure 167 examples, cure rate reaches 78.8%, effective 41 examples, invalid 4 examples, total effective rate reaches 98.1%.The patient with slight symptoms takes effect after taking a week, and the patient with severe symptoms serve on 3 courses of treatment, follows up a case by regular visits to the present invention through 6-10 month and does not have any untoward reaction, and chloasma faciei is had significant curative effect, and is safe and reliable.
Model case:
Case one: the king * *, the woman, 45 years old, facial pigmentation 5 years, there is butterfly-shaped dark brown speckle patient's cheekbone both sides.Delayed menstrual cycle, the few color of amount is dark, companion's lower abdomen pain, through the fore udder distending pain, feelings will irritability, dizziness, pale tongue with thin fur, pulsation string.Card belongs to qi depression to blood stasis.Control with blood circulation promoting and blood stasis dispelling circulation of qi promoting, the kidney invigorating speckle dispelling.Take 1 course of treatment of the present invention, above-mentioned all cards alleviate, and the mottle major part disappears, and continue again 2 courses of treatment of clothes the present invention, and chloasma disappears, and complexion is as usual.
Case two: old * *, the woman, 23 years old, the facial area chloasma was surplus March.Body is thin and weak, and the dysmenorrhea history is arranged.Now through after 2 days, lower abdomen dull pain, waist epidemic disease, weak, hectic fever, thin white fur of tongue, thready pulse.Card belongs to the deficiency of the kidney yin blood stasis.Control with blood stasis dispelling, regulating menstruation the kidney invigorating speckle dispelling.After taking the present invention 1 course of treatment, chloasma disappears.
Case three: Zhao * *, woman, 28 years old, facial pigmentation half a year.Patient post-abortion before half a year, chloasma faciei occurs.Existing menstruation rule, thin white fur of tongue, stringy pulse.After taking the present invention 1 course of treatment, the chloasma major part is desalinated, continues again and takes one week of the present invention, and chloasma disappears.

Claims (1)

1. medicine for the treatment of chloasma faciei is characterized in that: made by following Chinese herb raw materials by weight:
Folium Mori 20; Flos Chrysanthemi 20; Radix Trichosanthis 20; Rhizoma Paridis 15; Ilex purpurea Hassk.[I.chinensis Sims 20; The Radix Rehmanniae 20; Cortex Moutan 20; Radix Paeoniae Rubra 20; Radix Arnebiae (Radix Lithospermi) 20; Fructus Liquidambaris 20; Medulla Tetrapanacis 20; Poria 25; Rhizoma Typhonii 20; The Pseudobulbus Bletillae (Rhizoma Bletillae) 20; The Radix Angelicae Dahuricae 40; Rhizoma Cyperi 20; Rhizoma Chuanxiong 15; Herba Leonuri 35; Radix Angelicae Sinensis 20; The Radix Paeoniae Alba 20; Rhizoma Dioscoreae 50; Semen Coicis 30; Fructus Citri 20; Fructus Citri Sarcodactylis 20; Rhizoma sparganic 15; Rhizoma Curcumae 15; Fructus Ligustri Lucidi 40, Herba Ecliptae 40; Fructus Psoraleae 40; Fructus Corni 40; Semen Persicae 20; Semen Vaccariae 20; Flos Campsis 30; Flos Rosae Rugosae 30; Radix Notoginseng powder 1; According to described medicine material parts by weight, except the Radix Notoginseng powder, put into marmite, add cold water 800 weight portions, to soak 1 hour, after big fire was fried in shallow oil out, little fire was fried in shallow oil 15~20 minutes; Medicine juice is poured in the ready glass container; The medicine in the marmite is added cold water 300 weight portions, as above method is fried again, and medicine juice was poured into again in the glass container and mixed after secondary was boiled medicine, and twice admixing medical solutions 500 weight portion adds Radix Notoginseng powder 1 weight portion.
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CN105999118A (en) * 2016-07-26 2016-10-12 林红丽 Traditional Chinese medicinal composition for treating chloasma
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