CN103610982A - Medicine for treating rheumatic arthritis - Google Patents
Medicine for treating rheumatic arthritis Download PDFInfo
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Abstract
The invention discloses a medicine for treating rheumatic arthritis. The medicine is characterized by consisting of granules, tablets or capsules prepared from the following raw material medicines in parts by weight: 2-4 parts of masson pine bark, 1.5-2.5 parts of herba cepbalanoplosis segeti, 2.3-3.5 parts of white paeony root, 2-4 parts of sageretia theezans root, 1.5-2.5 parts of honeysuckle, 2-4 parts of pseudo-ginseng, 1.5-2.5 parts of baking soda, 2-4 parts of rhizoma heterosmilacis japonicae, 1.5-2.5 parts of radix rehmanniae recen and 1.5-2.5 parts of eleusine indica. The medicine is used for treating rheumatic arthritis, has a good curative effect after administration and has the effects of subsiding joint swelling, relieving pain and restoring functions of joints. According to preliminary clinical verification, the cure rate of rheumatic arthritis can be 74 percent, and the effective rate can be 96 percent. In addition, the medicine has the characteristics of simplicity and availability in raw materials, convenience in administration and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that is used for the treatment of rheumatic arthritis.
Background technology
Rheumatic arthritis is a kind of commonly encountered diseases and frequently-occurring disease.At present, doctor trained in Western medicine is used the medicines such as glucocorticoids, immunosuppressant to treat this disease more, though there is certain curative effect, therapeutic effect is unsatisfactory, and such medicine also has suitable toxic and side effects, and life-time service is larger to patient's harm.Through a large amount of clinical verifications, though Chinese medicine decoction has certain therapeutic effect for treatment rheumatic arthritis, but decoction decocting is cumbersome, and patient is difficult to adhere to for a long time taking.In addition, also there are clinically a large amount of Chinese medicine preparation to be applied to treat rheumatic arthritis, therapeutic effect is different, this class Chinese medicine preparation has various dosage forms, but medicament or the raw material of Chinese medicine of employing compatibility are nearly more than tens kinds mostly, manufacturing process very complex, so just applies and has brought many restrictions to it.
Summary of the invention
Task of the present invention is to provide a kind of medicine for the treatment of rheumatic arthritis, and this medicine is realized determined curative effect, medicine material is simple and easy to get, and taking convenience.
Its technical solution is:
Treat a medicine for rheumatic arthritis, the granule of being made by the crude drug of following weight portion, tablet or capsule:
Horse hair Cortex Pini Massonianae 2～4, Herba Cirsii 1.5～2.5, the Radix Paeoniae Alba 2.3～3.5, Sageretia theezans root 2～4, Flos Lonicerae 1.5～2.5, Radix Notoginseng 2～4, sodium bicarbonate 1.5～2.5, hargil Poria 2～4, Radix Rehmanniae 1.5～2.5, Herba Eleusines Indicae 1.5～2.5.
As a kind of preferred technical scheme, a kind of medicine for the treatment of rheumatic arthritis, the granule of being made by the crude drug of following weight portion, tablet or capsule:
Horse hair Cortex Pini Massonianae 3, Herba Cirsii 2, the Radix Paeoniae Alba 2.5, Sageretia theezans root 3, Flos Lonicerae 2, Radix Notoginseng 3, sodium bicarbonate 2, hargil Poria 3, Radix Rehmanniae 2, Herba Eleusines Indicae 2.
The present invention can be made into granule, capsule or tablet, and Coming-of-Age Day takes three times, each serving with 5～10 grams.
Pharmacology analysis:
Horse hair Cortex Pini Massonianae in the present invention, the dry bark of Pinus massoniana Lamb, has wind-damp dispelling, blood circulation promoting and blood stasis dispelling, pain relieving, hemostasis, the loose effect swelling and ache.Herba Cirsii, another name claims field thistle, luxuriant dish etc., has the effect of cooling blood for hemostasis, removing blood stasis to reduce swelling.The Radix Paeoniae Alba, has except effects such as arthralgia due to stagnation of blood, broken heavily fortified point amass, pain relieving, QI invigorating.Sageretia theezans (Sageretia theezans), according to the record of < < Chinese Plants will > > (Science Press, 1982), is Rhamnaceae, rattan shape or upright shrub; Sprig tool thorn, alternate or closely to life, brown, by pubescence; Originate in Yangtze River in China basin and southeastern coast each province, also there are distribution in Japan and India, are subtropical zone preferential species of tree; Sageretia theezans root, has the effects such as lowering the adverse-rising QI to resolve phlegm, wind-damp dispelling, benefit muscles and bones, can treat the diseases such as scabies, edema, the arthroncus of knee.Flos Lonicerae, has the effects such as dispelling wind-heat, removing summer-heat blood poison.Radix Notoginseng, has the effects such as dissipating blood stasis hemostasis, subduing swelling and relieving pain.Sodium bicarbonate, is weak base, can be rapidly after for oral administration in and gastric acid, a little less than its antiacid effect and of short duration.Hargil Poria, has the effects such as removing toxic substances dehumidifying, easing joint movement.Radix Rehmanniae, has clearing away heat and cooling blood, the effects such as YIN nourishing and the production of body fluid promoting.Herba Eleusines Indicae, has the effects such as heat clearing away, dampness removing.
Above-mentioned Ten Herbs use, can have removing toxic substances dehumidifying, strong muscles and bones, and reducing swelling and alleviating pain, easing joint movement, the effects such as expelling wind and removing dampness, have good curative effect for treatment rheumatic arthritis.
The present invention is used for the treatment of rheumatic arthritis, takes the rear good curative effect that all has, and has that arthroncus is disappeared, pain relief, and joint functional recovery improvement texts.Through clinical principium checking, for rheumatic arthritis cure rate, can reach more than 74%, effective percentage can reach more than 96%.In addition, also there is medicine material simple and easy to get, and the feature such as taking convenience.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
Treat a medicine for rheumatic arthritis, the granule of being made by the crude drug of following weight portion:
Horse hair Cortex Pini Massonianae 2, Herba Cirsii 1.5, the Radix Paeoniae Alba 2.3, Sageretia theezans root 2, Flos Lonicerae 1.5, Radix Notoginseng 2, sodium bicarbonate 1.5, hargil Poria 2, Radix Rehmanniae 1.5, Herba Eleusines Indicae 1.5.
Said medicine can adopt following preparation method, and the method comprising the steps of:
A is by 150 grams of 200 grams of horse hair Cortex Pini Massonianae, 150 grams of Herba Cirsiis, 230 grams of the Radix Paeoniae Albas, 200 grams of Sageretia theezans roots, 200 grams of Radix Notoginseng, 200 grams, hargil Poria and Herba Eleusines Indicae, mix, then decoct with water twice, add the water of 10～12 times at every turn, each decoction 3 hours, decocting liquid filters, and twice filtrate is merged, and mix homogeneously, then heating is concentrated into every ml and is equivalent to 2 grams of crude drugs.Add ethanol, the ethanol content adding reaches more than 75% again, after static 12 hours, filters, and reclaims ethanol, obtains solids, and this solids vacuum drying is ground into extractum fine powder, standby.
B is by 150 grams of 150 grams of Flos Loniceraes, 150 grams of sodium bicarbonate and Radix Rehmanniae, mix, then decoct with water twice, add the water of 8～10 times at every turn, each decoction 2 hours, decocting liquid filters, and twice filtrate is merged, and mix homogeneously, the clear paste of the relative density 1.30～1.50 when then heating is concentrated into 50 ℃.
The clear paste that the extractum fine powder that c obtains step a, step b obtain is mixed homogeneously in the ratio of 4:3:2 with maltodextrin, according to conventional method, makes granulated quickly dissolving, 10 grams of every bag of granule pastilles.
Usage: above-mentioned one bag of granule is poured in cup, added 100ml hot water dissolved, drink-service; Every day 3 times.
Embodiment 2
Treat a medicine for rheumatic arthritis, the granule of being made by the crude drug of following weight portion:
Horse hair Cortex Pini Massonianae 4, Herba Cirsii 2.5, the Radix Paeoniae Alba 3.5, Sageretia theezans root 4, Flos Lonicerae 2.5, Radix Notoginseng 4, sodium bicarbonate 2.5, hargil Poria 4, Radix Rehmanniae 2.5, Herba Eleusines Indicae 2.5.
Said medicine can adopt following preparation method, and the method comprising the steps of:
A is by 250 grams of 400 grams of horse hair Cortex Pini Massonianae, 250 grams of Herba Cirsiis, 350 grams of the Radix Paeoniae Albas, 400 grams of Sageretia theezans roots, 400 grams of Radix Notoginseng, 400 grams, hargil Poria and Herba Eleusines Indicae, mix, then decoct with water twice, add the water of 10～12 times at every turn, each decoction 3 hours, decocting liquid filters, and twice filtrate is merged, and mix homogeneously, then heating is concentrated into every ml and is equivalent to 2 grams of crude drugs.Add ethanol, the ethanol content adding reaches more than 75% again, after static 12 hours, filters, and reclaims ethanol, obtains solids, and this solids vacuum drying is ground into extractum fine powder, standby.
B is by 250 grams of 250 grams of Flos Loniceraes, 250 grams of sodium bicarbonate and Radix Rehmanniae, mix, then decoct with water twice, add the water of 8～10 times at every turn, each decoction 2 hours, decocting liquid filters, and twice filtrate is merged, and mix homogeneously, the clear paste of the relative density 1.30～1.50 when then heating is concentrated into 50 ℃.
The clear paste that the extractum fine powder that c obtains step a, step b obtain is mixed homogeneously in the ratio of 4:3:2 with maltodextrin, according to conventional method, makes granulated quickly dissolving, 10 grams of every bag of granule pastilles.
Usage: above-mentioned one bag of granule is poured in cup, added 100ml hot water dissolved, drink-service; Every day 3 times.
Embodiment 3
Treat a medicine for rheumatic arthritis, the granule of being made by the crude drug of following weight portion:
Horse hair Cortex Pini Massonianae 3, Herba Cirsii 2, the Radix Paeoniae Alba 2.5, Sageretia theezans root 3, Flos Lonicerae 2, Radix Notoginseng 3, sodium bicarbonate 2, hargil Poria 3, Radix Rehmanniae 2, Herba Eleusines Indicae 2.
Said medicine can adopt following preparation method, and the method comprising the steps of:
A is by 200 grams of 300 grams of horse hair Cortex Pini Massonianae, 200 grams of Herba Cirsiis, 250 grams of the Radix Paeoniae Albas, 300 grams of Sageretia theezans roots, 300 grams of Radix Notoginseng, 300 grams, hargil Poria and Herba Eleusines Indicae, mix, then decoct with water twice, add the water of 10～12 times at every turn, each decoction 3 hours, decocting liquid filters, and twice filtrate is merged, and mix homogeneously, then heating is concentrated into every ml and is equivalent to 2 grams of crude drugs.Add ethanol, the ethanol content adding reaches more than 75% again, after static 12 hours, filters, and reclaims ethanol, obtains solids, and this solids vacuum drying is ground into extractum fine powder, standby.
B is by 200 grams of 200 grams of Flos Loniceraes, 200 grams of sodium bicarbonate and Radix Rehmanniae, mix, then decoct with water twice, add the water of 8～10 times at every turn, each decoction 2 hours, decocting liquid filters, and twice filtrate is merged, and mix homogeneously, the clear paste of the relative density 1.30～1.50 when then heating is concentrated into 50 ℃.
The clear paste that the extractum fine powder that c obtains step a, step b obtain is mixed homogeneously in the ratio of 4:3:2 with maltodextrin, according to conventional method, makes granulated quickly dissolving, 10 grams of every bag of granule pastilles.
Usage: above-mentioned one bag of granule is poured in cup, added 100ml hot water dissolved, drink-service; Every day 3 times.
Trial edition invention Chinese medicine composition, in June, 2009 to 2012 year December for clinical observation, treatment 150 Patients with Knee Osteoarthritis patient.Clinical report is as follows:
1, physical data
In 150 routine patients, at 40～70 years old age, the course of disease is many at 6 months to 10 years, 58 years old mean age.In this 150 routine patient, using 50 examples of previous tretament as the first test group, using 50 examples of intermediate period treatment as the second test group, using 50 examples of Emergent therapy as the 3rd test group.
2, diagnostic criteria
With reference to the arthritis diagnosis and treatment guide draft gonarthritis diagnostic criteria > > in 2002 of rheumatism branch of < < Chinese Medical Association, draft: 1. nearly one month frequent gonalgia repeatedly; 2. X-ray film (erect position or Weight carrying position) joint space narrows down; 3. limpid, the thickness of joint fluid (at least 2 times), WBC≤200/ml; 4. person in middle and old age person (>=40 years old); 5. knee joint morning stiff≤30 minutes; When 6. movable, there is friction sound.Meet above-mentioned 1. with 2., or 3., 5. with 6., or 1., 4., 5. with 6. item forms diagnosis.According to sign: the 1. gonalgia, walking function obstacle, when fatigue and stair activity, symptom increases the weight of, and involves periarticular myalgia.2. health check-up knee joint is unrestrained swollen, patella and inside and outside Xiyan place tenderness+, patella grinds pain, floating patella test+, it is limited that knee joint is stretched flex, atrophy of quadriceps femoris.
3, Therapeutic Method and therapeutic outcome
About the first test group:
3.1 Therapeutic Method
3.11 prescriptions: take the granule that above-described embodiment 1 obtains.
3.12 usages: above-mentioned one bag of granule is poured in cup, added 100ml hot water dissolved, drink-service; Every day 3 times, once a bag.
3.13 courses for the treatment of: three courses for the treatment of.
3.2 therapeutic outcomes:
3.21 treatment evaluation criterias, the < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > formulating according to State Administration of Traditional Chinese Medicine judges:
Clinical cure: knee joint swelling, pain disappear, bends and stretches range of activity and recovers normal, and walking freely;
Effective: knee joint swelling substantially disappears or obviously goes down, and pain obviously alleviates, bend and stretch range of activity normal;
Take a turn for the better: knee joint swelling and pain all have and alleviates in various degree and alleviate, and bend and stretch range of activity and are also improved;
Invalid: knee joint swelling and pain are all without alleviating.
3.22 results: in 50 routine patients, clinical cure 37 examples (74%), effective example 7 (14%), 3 examples that take a turn for the better (6%), invalid 3 examples (6%), total effective rate is 94%.
About the second test group:
3.3 Therapeutic Method
3.31 prescriptions: take the granule that above-described embodiment 2 obtains.
3.32 usages: above-mentioned one bag of granule is poured in cup, added 100ml hot water dissolved, drink-service; Every day 3 times, once a bag.
3.33 courses for the treatment of: three courses for the treatment of.
3.4 therapeutic outcome
3.41 treatment evaluation criterias, the < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > formulating according to State Administration of Traditional Chinese Medicine judges:
Clinical cure: knee joint swelling, pain disappear, bends and stretches range of activity and recovers normal, and walking freely;
Effective: knee joint swelling substantially disappears or obviously goes down, and pain obviously alleviates, bend and stretch range of activity normal;
Take a turn for the better: knee joint swelling and pain all have and alleviates in various degree and alleviate, and bend and stretch range of activity and are also improved;
Invalid: knee joint swelling and pain are all without alleviating.
3.42 results: in 50 routine patients, clinical cure 38 examples (76%), effective example 10 (20%), 1 example that takes a turn for the better (2%), invalid 1 example (2%), total effective rate is 98%.
About the 3rd test group:
3.5 Therapeutic Method
3.51 prescriptions: take the granule that above-described embodiment 3 obtains.
3.52 usages: above-mentioned one bag of granule is poured in cup, added 100ml hot water dissolved, drink-service; Every day 3 times, once a bag.
3.53 courses for the treatment of: three courses for the treatment of.
3.6 therapeutic outcome
3.61 treatment evaluation criterias, the < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > formulating according to State Administration of Traditional Chinese Medicine judges:
Clinical cure: knee joint swelling, pain disappear, bends and stretches range of activity and recovers normal, and walking freely;
Effective: knee joint swelling substantially disappears or obviously goes down, and pain obviously alleviates, bend and stretch range of activity normal;
Take a turn for the better: knee joint swelling and pain all have and alleviates in various degree and alleviate, and bend and stretch range of activity and are also improved;
Invalid: knee joint swelling and pain are all without alleviating.
3.62 results: in 50 routine patients, clinical cure 40 examples (80%), effective example 9 (18%), invalid 1 example (1%), total effective rate is 98%.
Model case wherein:
Case 1, king so-and-so, man, 60 years old, first visit on June 25 in 2009, two knee joints are weak, pain, squat down limited 6 years, increase the weight of six months.Have a medical check-up: the inside and outside Xiyan of double knee joint and fat pad place tenderness (++), 10 ° of 80 ° of outward turnings of left knee joint flexing, 100 ° of right knee joint flexings, 15 ° of outward turnings, squat down obviously limited.X-ray film shows: two knee joint patella osteomalacia, fat pad calcification, and between tibial plateau and condyle, ridge hyperosteogeny is obvious; The calcification of knee joint peripheral ligament, articular surface cartilage wearing and tearing, part comes off, gap turn narrow, not wide, joint deformity, with left knee joint for very.Diagnosis: two knee osteoarthritiss.Through above-mentioned treatment, further consultation result after month: patient main suit's double knee joint pain obviously alleviates, and the function of squatting down is obviously improved, look into two inside and outside Xiyans of knee joint without tenderness, 140 ° of left knee joint flexings, 20 ° of outward turnings, 145 ° of left knee joint flexings, 20 ° of outward turnings, X shows: two knee joint patella density, articular surface is normal, fat pad calcification, ridge hyperosteogeny between tibial plateau and condyle, knee joint peripheral ligament density is normal, joint space broadens, and it is normal that the joint line of force is recovered, and reached clinical cure standard.
Case 2, Lee, female, 45 years old, first visit on March 10 in 2011, nearly 1 year of two gonalgia, over nearly one month, right swelling and pain in knee obviously increases the weight of, and upper all needs staircase downstairs, and seat dysstasia is met overcast and rainy symptom obvious, and morning is stiff, and idol has interlocking phenomenon.Check: inner side tenderness under kneecap: left knee joint (+), right knee joint (++); Right knee joint is micro-swollen, right Range of motion of knee joint: 45 °; Tongue is greasy in vain, stringy and rolling pulse.Diagnosis: knee osteoarthritis.Through above-mentioned treatment, further consultation result after one and a half months, recovery from illness.
Case 3, Zhang, man, 52 years old, first visit on June 11 in 2012, main suit: the right side gonalgia more than 3 years, increases the weight of one month.At the beginning of 2012, there is the right side gonalgia, companion's difficulty in walking, oral administration Western medicine and physical therapy symptom alleviate, but outbreak repeatedly.Month cause is suffered from cold and is caused pain and increase the weight of, and short walk and stair activity be difficulty all.The right knee joint of the patient that haves a medical check-up is local without red and swollen, the obvious tenderness in neix place, right side, and X-ray film shows right knee joint degeneration.Through above-mentioned treatment, further consultation result after month, main suit: right knee joint is weak, pain disappears, squats down and recovers normal.Look into the inside and outside Xiyan of right knee joint without tenderness, 140 ° of right knee joint flexings, 20 ° of outward turnings, X shows: knee joint patella density, articular surface is normal, fat pad calcification, ridge hyperosteogeny between tibial plateau and condyle, knee joint peripheral ligament density is normal, and joint space broadens, it is normal that the joint line of force is recovered, and reached clinical cure standard.
In addition to the implementation, medicine of the present invention can also be made tablet or capsule.
The relevant technologies content of not addressing in aforesaid way is taked or is used for reference prior art and can realize.
It should be noted that, under the instruction of this description, those skilled in the art can also make such or such easy variation pattern, such as equivalent way, or obvious mode of texturing.Above-mentioned variation pattern all should be within protection scope of the present invention.
Claims (2)
1. treat a medicine for rheumatic arthritis, it is characterized in that granule, tablet or the capsule by the crude drug of following weight portion, made:
Horse hair Cortex Pini Massonianae 2～4, Herba Cirsii 1.5～2.5, the Radix Paeoniae Alba 2.3～3.5, Sageretia theezans root 2～4, Flos Lonicerae 1.5～2.5, Radix Notoginseng 2～4, sodium bicarbonate 1.5～2.5, hargil Poria 2～4, Radix Rehmanniae 1.5～2.5, Herba Eleusines Indicae 1.5～2.5.
2. a kind of medicine for the treatment of rheumatic arthritis according to claim 1, is characterized in that the weight portion proportioning of above-mentioned raw materials medicine is:
Horse hair Cortex Pini Massonianae 3, Herba Cirsii 2, the Radix Paeoniae Alba 2.5, Sageretia theezans root 3, Flos Lonicerae 2, Radix Notoginseng 3, sodium bicarbonate 2, hargil Poria 3, Radix Rehmanniae 2, Herba Eleusines Indicae 2.
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| CN201310647066.5A CN103610982B (en) | 2013-02-19 | 2013-12-04 | A kind of medicine for the treatment of rheumatic arthritis |
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| CN2013100534254 | 2013-02-19 | ||
| CN201310053425.4 | 2013-02-19 | ||
| CN2013100534254A CN103100010A (en) | 2013-02-19 | 2013-02-19 | Drug for treatment of rheumatic arthritis |
| CN201310647066.5A CN103610982B (en) | 2013-02-19 | 2013-12-04 | A kind of medicine for the treatment of rheumatic arthritis |
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| CN201310647066.5A Expired - Fee Related CN103610982B (en) | 2013-02-19 | 2013-12-04 | A kind of medicine for the treatment of rheumatic arthritis |
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| CN103393824A (en) * | 2013-07-19 | 2013-11-20 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine containing radix aconiti preparata and preparation method thereof |
| CN103623091B (en) * | 2013-12-04 | 2015-04-15 | 武瑞美 | Medicament for external use for treating gout |
| CN104258316A (en) * | 2014-10-31 | 2015-01-07 | 蔡明杰 | Pharmaceutical composition for treating rheumatic arthritis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1868535A (en) * | 2005-05-27 | 2006-11-29 | 王楚清 | Medicine composition for treating rheumatic arthritis and rheumatoid arthritis, and its prepn. method |
| CN102488879A (en) * | 2011-12-22 | 2012-06-13 | 赵国辉 | Medicinal composition for treating rheumatism |
| CN102526451A (en) * | 2010-12-15 | 2012-07-04 | 黄启仁 | Traditional Chinese medicine formula for activating tibia |
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| CN101579434A (en) * | 2008-05-15 | 2009-11-18 | 刘人源 | Traditional Chinese medicine preparation for curing femoral head necrosis and vasculitis |
| CN101919988B (en) * | 2009-06-10 | 2011-10-26 | 胡国伟 | Medicine compound for curing rheumatism rheumatoid arthritis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1868535A (en) * | 2005-05-27 | 2006-11-29 | 王楚清 | Medicine composition for treating rheumatic arthritis and rheumatoid arthritis, and its prepn. method |
| CN102526451A (en) * | 2010-12-15 | 2012-07-04 | 黄启仁 | Traditional Chinese medicine formula for activating tibia |
| CN102488879A (en) * | 2011-12-22 | 2012-06-13 | 赵国辉 | Medicinal composition for treating rheumatism |
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