[summary of the invention]
Technical problem to be solved by this invention is to overcome that the treatment cycle of common in the market treatment cervical spondylosis and various osteoarthritis medicines is long, the efficacy of a drug can not be gone directly, and disease institute, unsatisfactory curative effect, drug effect are lasting, defectives such as expense is higher, maneuver complexity, provide a kind of evident in efficacy, effect fast, lasting medicine, the through sick institute of the efficacy of a drug, cost be lower, be suitable for taking for a long time and the treatment cervical spondylosis that has no side effect and the pharmaceutical composition of various joint disease.
Technical problem to be solved by this invention realizes by following technological approaches:
A kind of pharmaceutical composition for the treatment of cervical spondylosis and various joint disease of the present invention, mainly form by the component of following weight portion:
5~50 parts of Ramulus Cinnamomi, 3~30 parts of Radix Angelicae Sinensis, 3~30 parts of Radix Saposhnikoviaes, 1~30 part of Rhizoma Chuanxiong, 1~30 part of Rhizoma Et Radix Notopterygii, 2~30 parts of Radix Angelicae Pubescentiss, 5~50 parts of the Radixs Linderae, 5~50 parts of Rhizoma Cyperis, 5~30 parts of the Radix Aucklandiae, 3~30 parts of Radix Paeoniae Rubra, 5~50 parts of the Radix Paeoniae Albas, 5~50 parts of Cortex Lycii, 3~30 parts of Radix Salviae Miltiorrhizaes, 3~30 parts of Radixs Stephaniae Tetrandrae, 5~40 parts of Cortex Acanthopanciss, 2~30 parts of the Cortexs Eucommiae, 2~30 parts of cattle sunset, 5~50 parts in Poria, 3~30 parts of Cortex Magnoliae Officinalis, 2~30 parts of Rhizoma Atractylodis, 2~30 parts of Rhizoma Alismatis, 3~40 parts of the Rhizoma Atractylodis Macrocephalaes, 5~50 parts of Cortex Cinnamomis, 3~30 parts of Rhizoma Zingiberiss, 2~30 parts in Pericarpium Zanthoxyli, 2~30 parts of Flos Caryophyllis, 1~30 part of Radix Curcumae, 1~50 part of Rhizoma Corydalis, 1~20 part on Flos Carthami, 1~20 part in Semen Persicae, 2~50 parts of Herba Leonuris, 3~50 parts of Rhizoma Dioscoreaes.
Be preferably:
40 parts of Ramulus Cinnamomi, 20 parts of Radix Angelicae Sinensis, 30 parts of Radix Saposhnikoviaes, 10 parts of Rhizoma Chuanxiongs, 20 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Pubescentiss, 30 parts of the Radixs Linderae, 30 parts of Rhizoma Cyperis, 20 parts of the Radix Aucklandiae, 20 parts of Radix Paeoniae Rubra, 30 parts of the Radix Paeoniae Albas, 30 parts of Cortex Lycii, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radixs Stephaniae Tetrandrae, 30 parts of Cortex Acanthopanciss, 20 parts of the Cortexs Eucommiae, 20 parts of cattle sunset, 30 parts in Poria, 20 parts of Cortex Magnoliae Officinalis, 20 parts of Rhizoma Atractylodis, 20 parts of Rhizoma Alismatis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 10 parts in Pericarpium Zanthoxyli, 10 parts of Flos Caryophyllis, 10 parts of Radix Curcumaes, 10 parts of Rhizoma Corydalis, 10 parts on Flos Carthami, 10 parts in Semen Persicae, 20 parts of Herba Leonuris, 30 parts of Rhizoma Dioscoreaes.
The weight portion consumption of each component of pharmaceutical composition of the present invention can also be:
3~50 parts of Radix Astragali, 2~30 parts of Semen Plantaginiss, 1~20 part of Herba Menthae, 5~50 parts of Radix Puerariaes, 2~20 parts of Flos Chrysanthemis, 1~20 part in Herba Ephedrae, 3~30 parts of Fructus Forsythiaes, 5~50 parts of Herba Taraxaci, 3~50 parts of Cortex Moutans, 5~50 parts of Massa Medicata Fermentata, 2~30 parts of Radix Codonopsis, 2~30 parts of Radix Adenophorae (Radix Glehniae), 3~30 parts of Fructus Lyciis.
Be preferably:
30 parts of Radix Astragali, 20 parts of Semen Plantaginiss, 10 parts of Herba Menthaes, 30 parts of Radix Puerariaes, 20 parts of Flos Chrysanthemis, 10 parts in Herba Ephedrae, 20 parts of Fructus Forsythiaes, 30 parts of Herba Taraxaci, 20 parts of Cortex Moutans, 30 parts of Massa Medicata Fermentata, 20 parts of Radix Codonopsis, 10 parts of Radix Adenophorae (Radix Glehniae), 10 parts of Fructus Lyciis.
Aforementioned pharmaceutical compositions of the present invention adds various conventional adjuvant required when preparing different dosage forms, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be pill, tablet, capsule, powder, granule or oral liquid etc.
Pharmaceutical composition of the present invention is based on the differential diagnosis of diseases and the dialectical principle that combines of Chinese traditional treatment cervical spondylosis and various joint disease, treating both the principal and secondary aspects of a disease, deficiency and excess is double to be controlled, internal and external application, filter out and have blood circulation promoting and blood stasis dispelling, regulate the flow of vital energy and promote blood circulation, anti-inflammatory analgetic, the muscle flesh of releiving, interior muscles and bones, close the natural plant of fur outward, according to the theory of Chinese medical science prescription, form according to certain weight portion proportioning.
Pharmaceutical composition of the present invention is got involved various conventional adjuvant required when preparing different dosage forms, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the Chinese medicinal preparation method of routine, for example can be ball, tablet, capsule, powder, granule or oral liquid etc.
The used Chinese medicine of the present invention all can be buied from the Chinese medicine shop, and its specification meets national medical standard.
Usage and consumption: dosage of the present invention depends on concrete dosage form, factors such as patient age, body weight, health status.As guidance: oral: 1) capsule: every day three times, each 2~6, every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2~6, every content of dispersion 0.4 gram, warm water takes.3) pill: every day three times, each 2~5 grams, warm water takes.4) capsule: every day three times, each 2~6, every content of dispersion 0.4 gram, warm water takes.5) granule: every day three times, each 3~5 grams, warm water takes.
The present invention is directed to the intrinsic functional imbalance of cervical spondylosis and various joint disease, affection of exogenous wind-cold heat-damp in summer etc. cause the body meridians to hinder, blood vessels are obstructed, and QI-blood circulation is not smooth, the muscles and bones arthralgia, aching pain of muscles, spasm of muscles and vessels, symptoms such as skin and flesh deflation, to alleviation cervical vertebra muscular tone, the vertigo, extremity are unsuccessful, arthralgia, pain in the lumbar region skelalgia, limb activity inconvenience, the muscle arteries and veins is go the rounds and is obstructed, stagnation of QI-blood, and the cold resistance of blood vessels waits reaction, the mutual synergism of various crude drug can be brought into play drug effect to greatest extent, make the efficacy of a drug sick institute that goes directly, relief of symptoms is given the light sense of whole body fast, can effectively improve body self healing ability, can be significantly, improve symptom apace, have effect in addition lastingly, drug effect is reliable, easy to use, be suitable for life-time service, expense is lower, and advantage such as have no side effect.
[specific embodiment]
Further describe the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never limit the scope of the invention.
The preparation of [embodiment 1] capsule
Take by weighing each crude drug by following weight portion: 40 parts of Ramulus Cinnamomi, 20 parts of Radix Angelicae Sinensis, 30 parts of Radix Saposhnikoviaes, 10 parts of Rhizoma Chuanxiongs, 20 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Pubescentiss, 30 parts of the Radixs Linderae, 30 parts of Rhizoma Cyperis, 20 parts of the Radix Aucklandiae, 20 parts of Radix Paeoniae Rubra, 30 parts of the Radix Paeoniae Albas, 30 parts of Cortex Lycii, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radixs Stephaniae Tetrandrae, 30 parts of Cortex Acanthopanciss, 20 parts of the Cortexs Eucommiae, 20 parts of cattle sunset, 30 parts in Poria, 20 parts of Cortex Magnoliae Officinalis, 20 parts of Rhizoma Atractylodis, 20 parts of Rhizoma Alismatis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 10 parts in Pericarpium Zanthoxyli, 10 parts of Flos Caryophyllis, 10 parts of Radix Curcumaes, 10 parts of Rhizoma Corydalis, 10 parts on Flos Carthami, 10 parts in Semen Persicae, 20 parts of Herba Leonuris, 30 parts of Rhizoma Dioscoreaes.
Each component of above-mentioned weight portion mixed to grind into incapsulate promptly after fine powder is crossed 1500 mesh sieves.
The preparation of [embodiment 2] granule
Take by weighing each crude drug by following weight portion: 40 parts of Ramulus Cinnamomi, 20 parts of Radix Angelicae Sinensis, 30 parts of Radix Saposhnikoviaes, 10 parts of Rhizoma Chuanxiongs, 20 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Pubescentiss, 30 parts of the Radixs Linderae, 30 parts of Rhizoma Cyperis, 20 parts of the Radix Aucklandiae, 20 parts of Radix Paeoniae Rubra, 30 parts of the Radix Paeoniae Albas, 30 parts of Cortex Lycii, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radixs Stephaniae Tetrandrae, 30 parts of Cortex Acanthopanciss, 20 parts of the Cortexs Eucommiae, 20 parts of cattle sunset, 30 parts in Poria, 20 parts of Cortex Magnoliae Officinalis, 20 parts of Rhizoma Atractylodis, 20 parts of Rhizoma Alismatis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 10 parts in Pericarpium Zanthoxyli, 10 parts of Flos Caryophyllis, 10 parts of Radix Curcumaes, 10 parts of Rhizoma Corydalis, 10 parts on Flos Carthami, 10 parts in Semen Persicae, 20 parts of Herba Leonuris, 30 parts of Rhizoma Dioscoreaes.
Each crude drug of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 1500 mesh sieves, add ethanol and make adhesive, add starch and do filler, be pressed into granule promptly.
The preparation of [embodiment 3] tablet
Take by weighing each crude drug by following weight portion: 40 parts of Ramulus Cinnamomi, 20 parts of Radix Angelicae Sinensis, 30 parts of Radix Saposhnikoviaes, 10 parts of Rhizoma Chuanxiongs, 20 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Pubescentiss, 30 parts of the Radixs Linderae, 30 parts of Rhizoma Cyperis, 20 parts of the Radix Aucklandiae, 20 parts of Radix Paeoniae Rubra, 30 parts of the Radix Paeoniae Albas, 30 parts of Cortex Lycii, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radixs Stephaniae Tetrandrae, 30 parts of Cortex Acanthopanciss, 20 parts of the Cortexs Eucommiae, 20 parts of cattle sunset, 30 parts in Poria, 20 parts of Cortex Magnoliae Officinalis, 20 parts of Rhizoma Atractylodis, 20 parts of Rhizoma Alismatis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 10 parts in Pericarpium Zanthoxyli, 10 parts of Flos Caryophyllis, 10 parts of Radix Curcumaes, 10 parts of Rhizoma Corydalis, 10 parts on Flos Carthami, 10 parts in Semen Persicae, 20 parts of Herba Leonuris, 30 parts of Rhizoma Dioscoreaes.
Each crude drug of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 1500 mesh sieves, make granule, and the compacting of dry back in flakes promptly.
The preparation of [embodiment 4] pill
Take by weighing each crude drug by following weight portion: 40 parts of Ramulus Cinnamomi, 20 parts of Radix Angelicae Sinensis, 30 parts of Radix Saposhnikoviaes, 10 parts of Rhizoma Chuanxiongs, 20 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Pubescentiss, 30 parts of the Radixs Linderae, 30 parts of Rhizoma Cyperis, 20 parts of the Radix Aucklandiae, 20 parts of Radix Paeoniae Rubra, 30 parts of the Radix Paeoniae Albas, 30 parts of Cortex Lycii, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radixs Stephaniae Tetrandrae, 30 parts of Cortex Acanthopanciss, 20 parts of the Cortexs Eucommiae, 20 parts of cattle sunset, 30 parts in Poria, 20 parts of Cortex Magnoliae Officinalis, 20 parts of Rhizoma Atractylodis, 20 parts of Rhizoma Alismatis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 10 parts in Pericarpium Zanthoxyli, 10 parts of Flos Caryophyllis, 10 parts of Radix Curcumaes, 10 parts of Rhizoma Corydalis, 10 parts on Flos Carthami, 10 parts in Semen Persicae, 20 parts of Herba Leonuris, 30 parts of Rhizoma Dioscoreaes.
Each crude drug of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 800~1200 mesh sieves, make ball promptly.
The clinical observation on the therapeutic effect test of [test example] medicine composite for curing cervical spondylosis of the present invention and various joint disease
The physical data of experimental subject: adopt pharmaceutical composition of the present invention to treat 57 altogether
The example patient, wherein male 29 examples, women 18 examples; The oldest person 67 years old, age reckling 15 years old.
Therapeutic Method:
Usage and consumption: adopt the prepared medicament of the embodiment of the invention, its usage and consumption are as follows: 1) capsule: every day three times, and each 2~6, every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2~6, every content of dispersion 0.4 gram, warm water takes.3) pill: every day three times, each 2~5 grams, warm water takes.4) capsule: every day three times, each 2~6, every content of dispersion 0.4 gram, warm water takes.5) granule: every day three times, each 3~5 grams, warm water takes.
The course of treatment: one month is a course of treatment, treats three courses of treatment altogether.
Efficacy assessment standard:
Produce effects: sign has remarkable change, and symptom is clearly better, and the X line shows that osteoarthrosis improves significantly.
Effectively: sign has certain change, and symptom has improvement, and the X line shows that osteoarthrosis has improvement.
Invalid: sign does not change, and symptom does not have improvement, and the X line shows the osteoarthrosis no change.
Model case:
1, Wang, man, 43 years old, company manager.
Owing to bend over one's desk working for a long time, suffer from the cervical spondylosis more than two decades, clapped the X line before 15 years and show:
The whole adhesions in cervical vertebra joint, bony spur interpenetrates, and cervical vertebra is tetanic, and the physiology curvature disappears.And the deflation of neck shoulder muscle, head movement is unfavorable, hears during rotation that cervical vertebra screaks, and random thoughts are dizzy, symptoms such as finger tip numbness.Patient's life-time service the whole bag of tricks treatment once, as methods such as acupuncture, massage, massage, cupping, scrape therapy, Chinese medicine for oral administration and externally applied ointments, only take effect, do not see recovery from illness, and use a kind of means after treatment a period of time, effect can be had to abandon worse and worse at last, selects the other treatment method separately.Go round and begin again, lose the confidence.
Begin to take pharmaceutical composition of the present invention in October, 07, every day three times, each 6, after two days, the patient is conscious, and cervical vertebra is free and relaxed, and muscle flesh is releived, shoulder back of the body sense of heaviness subtracts greatly, after one month, through the X ray examination, the cervical vertebra joint accretion significantly improves, take pharmaceutical composition of the present invention again, every day three times, each 5, amount to March, various symptoms disappear substantially.
2, Yang, woman, 65 years old, peasant.
The patient has pain from beginning at an early age during the waist lower limb, because the restriction of family's condition fails to obtain medical treatment.From 05 beginning, lumbago and skelalgia happens occasionally, whole body articular instability in the time of very, and limbs fatigue can not be walked and take care of oneself, and thinks through the X ray examination: lumbar vertebra outmoded injury and lumbar intervertebral disc prolapse.08 on December began to take pharmaceutical composition of the present invention every day three times in 7, each six, second day conscious taking a favorable turn, whole body is light, activity is relatively more convenient, serve on one month after, X ray examination, lumbar intervertebral disc are deviate from and are preceding compared obvious improvement.Other symptom is greatly taken on a new look, and symptom turns for the better by and large behind the first quarter moon, at present still in receiving treatment.
3, Liu so-and-so, man, 44 years old, certain chief inspector of building constructor.
Because the patient lives in the rural area since the childhood, condition is arduouser, and is uncared in addition, the fishing of often going to river, severe winter does not miss according to catching yet, the patient is conscious of 30 years old, and it is uncomfortable that always feel in each joint of whole body, and muscle is tightly short, the contracture of muscle arteries and veins, feel cold every winter from interior and go out, health is shivered sometimes, and once long-term medication treatment had no resolution.
Begin to take pharmaceutical composition of the present invention in August, 06, every day three times, each 6, after one month, whole body is free and relaxed, and the joint is bent and stretched nimble, does not have cold again from interior and sensation that go out, and after took medicine three months, conscious complete obiteration is almost recovered.
4, Lee so-and-so, woman, 42 years old, company clerk.
Patient's readme went to the seabeach, Qinhuangdao to play before more than ten years, health is tired out after the swimming, health is embedded in the sand falls asleep, and the aftersensation whole body of waking up is ice-cold, rustle as shiver, menses soon, is promptly felt dizzy pain when row after going home at a time when this, go cold all over, muscle tightens, and the muscle arteries and veins is twitched, and menses is inaccurate.Once obeying the high amount of drug treatment has no resolution.
In August, 08, take pharmaceutical composition of the present invention, every day three times, each 6, after January, whole body is free and relaxed, and conscious muscles and bones is penetrating, and the muscle arteries and veins is releived, and various symptoms are greatly improved.Took pharmaceutical composition of the present invention again two months, normal substantially.
5, Lee, woman, 63 years old, peasant.
Because sons and daughters patient are more, life phase is fallen sick from overwork when arduous, becomes rheumatalgia eventually.General malaise, lumbago and skelalgia, the joint joint stuffiness, finger swells and ache, and the left hand third finger and right hand forefinger, middle finger, nameless arthroncus distortion are half bending, can't stretch or clench fist.Begin to take pharmaceutical composition of the present invention 06 year summer, every day three times, each six, releive in two weeks aftersensation joint, and both hands firmly can be held fist substantially, and behind the two weeks, both hands are clenched fist freely again, and lumbago and skelalgia is alleviated substantially, and finger swelling sense significantly improves.Take pharmaceutical composition of the present invention again, every day three times, each six, treated two months, greatly take a turn for the better.
6, Liu so-and-so, the man, 47 years old, unemployed.
Patient's health since the childhood is thin and weak, once suffers from a heart complaint, and after the major operation, finds hepatitis B again, prolapse of lumbar intervertebral disc disease, hyperosteogeny of cervical vertebra etc.Cervical vertebra stiffness can not rotary head, lumbar and back pain, and lower limb is soft unable, diseases such as numbness of hands and feet.Through taking pharmaceutical composition of the present invention, every day three times, each six, after one month, symptom greatly alleviates, and takes pharmaceutical composition of the present invention continuously two months again, and prolapse of lumbar intervertebral disc significantly takes a turn for the better, pain disappears, the almost imperceptible uncomfortable reaction of cervical vertebra, and numbness of hands and feet disappears.
7, Hu, woman, 36 years old, corporate accounting.
Patient's cervical spondylosis more than ten years, often occur dizzy, numbness of the fingers, acid precipitation such as omoplate back are unable, can't walk in the time of very, the sideslip of walking, the several years can not go to work, the X ray examination shows: hyperosteogeny of cervical vertebra, tetanic.
Take pharmaceutical composition of the present invention at the beginning of 08, every day three times, each six, symptom greatly alleviates after one month, the cervical vertebra activity freely, phenomenons such as giddy, numbness of hand wood disappear substantially.Take pharmaceutical composition of the present invention again after one month, show through the X ray examination: the tetanic more preceding obvious improvement of cervical vertebra, bony spur diminishes.After take a pharmaceutical composition of the present invention drug withdrawal in month, all symptoms are basic all to disappear.
8, Lee, woman, 35 years old, certain manager of Auditing firm.
The patient feels cervical vertebra and lumbar vertebra discomfort when being in high school, because study is nervous, row is not checked all the time.Dizziness when being educated in the university, neck rotate symptoms such as inconvenience, pain in the lumbar region and happen occasionally, but still can adhere to.Soon, the sensation dizziness is more and more obvious after working in 99 years, and pain in the lumbar region is continuous, find on inspection, and tetanic, the hypertrophy of cervical vertebra, lumbar intervertebral disc is deviate from.Once took Chinese medicine and acupuncture and moxibustion therapy, effect still can, but symptom is recovered in the past again after the drug withdrawal.
08 year, take pharmaceutical composition of the present invention, every day three times, each five.Movable convenient less than first quarter moon sensation cervical vertebra, flank pain subtracts greatly.Took pharmaceutical composition of the present invention again two months, all symptoms turn for the better by and large.
Therapeutic outcome:
Among the 57 routine patients that treated, through treatment in three months, wherein produce effects 48 examples were effective
9 examples, total effective rate reaches 100%.The result shows that pharmaceutical composition of the present invention has significant curative effect to patients such as treatment cervical spondylosis, lumbago and skelalgia and rheumatalgia.Clinical efficacy is significantly reliable, and the characteristic of Chinese medicine and advantage can be brought into play and use to greatest extent.