CN101518630A - Anti-gout traditional Chinese medical composition and preparation method thereof - Google Patents

Abstract

The invention relates to an anti-gout traditional Chinese medical composition, which is prepared with rhizoma atractylodis, radix cyathulae, coix seed, gypsum, radices gentianae macrophyllae, aspongopus, suberect spatholobus stem, papaya, pericarpium citri reticulatae, bulbus fritillariae cirrhosae, giant knotweed rhizome, tuckahoe, rhizoma alismatis, Yunnan wintergreen stem and leaf, bark of tree peony root, cornus dogwood fruit, yam, broomrape, Chinese dodder seed, medicinal indianmulberry root and/or a pharmaceutically acceptable carrier. The invention also relates to a preparation method of the traditional Chinese medical composition. The traditional Chinese medical composition has the functions of clearing away heat, removing dampness, activating blood and dredging collaterals, and is used for treating the symptoms of joint red swelling, heat pain, difficulty in flexion and extension and the like caused by gout due to disease of moist heat and blood stasis.

Description

Chinese medicine composition of a kind of gout and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to Chinese medicine composition of a kind of gout and preparation method thereof.

Background technology

Gout is that the excessive production of uric acid or uric acid row is rushed down insufficient uric acid that causes and piled up and cause, and uric acid crystal is deposited in cartilage, soft tissue, kidney and joint.Deposition at joint can cause violent pain.

The cause of gout is a hyperuricemia, and the reason by hyperuricemia forms can be divided into gout constitutional and Secondary cases two classes.On this basis, according to uricopoiesis and metabolism situation, can be further divided into again and generated many types of and drain the minimizing type.

Uricopoiesis is many types of excessively: mainly be because due to the nucleic acid metabolism enhancing, promptly a variety of causes causes that purine bases are too much synthetic or it is too fast to degrade, and the purine metabolism product is too much, causes blood uric acid to increase.

Drain the minimizing type: in the body free uric acid about 2/3 by renal excretion, 1/3 by digestive tract along with the passive discharge of intestinal juice, uric acid is excreted by bacterial degradation ammonification and carbon dioxide in colon.Low excretion pattern patient nucleic acid in vivo metabolism does not strengthen, and is mainly the renal excretion hypofunction, and urate excretion is crossed slow and the rising of hyperamization uric acid level.

According to investigations, China hyperuricemia patient number reaches 1.2 hundred million at present, and wherein patient with gout surpasses 7,500 ten thousand people, and just increases with annual 0.97% annual rate of growth, gout has become China with the same second largest metabolism class disease of diabetes, and serious harm people's life and health.

According to American-European statistics to the patient with gout cause of death, in the complication that produces because of gout, account at most to merge ischemic heart desease, secondly be uremia, cerebrovascular disease, malignant tumor etc.But the research Japanese in the area, Asia is to rank first with uremia, and next is only ischemic heart desease, cerebrovascular disease and malignant tumor.No matter be which type of complication, these research statistical datas all are worth us to pay attention to.

1, kidney malfunction: if gout does not have treatment carefully, then continue hyperuricemia for a long time, can make too much urate crystal Shen Dian in kidney, cause gouty nephropathy, or cause the kidney malfunction.

2, ischemic heart desease: so-called ischemic heart desease, be meant delivering oxygen and nutrition coronary atherosclerosis or obstruction to cardiac muscle, so that the circulation of blood is hindered, thereby cause chest pain and myocardial necrosis, mainly contain angina pectoris and myocardial infarction, this just looks like that running water pipe is the same, because the relation of dirt obstruction, the water pipe bore is more and more little, causes discharge minimizing or obstructed fully eventually.All can take place this strictly speaking situation per capita, the influence of different is some people can be subjected to specific factor and acceleration, and AHA just classifies gout as the risk factor and the arteriosclerotic promotion factor of ischemic heart desease at present.Because gout is as not treatment carefully, the hyperuricemia that continues can make too much urate crystal Shen Dian in coronary artery, adds that hematoblastic coagulation is hyperfunction, has all quickened arteriosclerotic progress.

3, renal calculus: according to statistics, the probability that renal calculus appears in gout patient is about 1,000 times of the normal person; Therefore because the uric acid amount in the urine is many more, acid-base value is sour more, easy more generation calculus must many excessive pathogenic heat in febrile disease boiled water, take sodium bicarbonate to prevent the generation of renal calculus.

4. obesity: China is owing to economically grow up fast, the grain abundance, and therefore fat people is more and more; Obesity not only can make uric acid synthetic hyperfunction, causes hyperuricemia, also can hinder the drainage of uric acid, easily causes gout, merges hyperlipidemia, diabetes etc.Its main cause is frequent eating and drinking too much at one meal, so the overweight people should lose weight.

5. hyperlipidemia: the normal eating and drinking too much at one meal of the people of gout, and fat phenomenon is arranged more, therefore merge a lot of of hyperlipidemia, this with arteriosclerosis takes place that very confidential relation is arranged.

6. diabetes: the gout sufferer is done the oral glucose stress test, found that 30-40% merges " light disease non-insulin-depending type " diabetes; That be obesity and eating and drinking too much at one meal cause insulin susceptibility low due to, if can just use dietetic therapy in early days, and controlling body weight, the susceptibility of insulin is very fast can restore.

7. hypertension: the goat people is half complicated hypertension approximately, and except the above-mentioned renal hypertension that causes because of the kidney malfunction, it also is one of reason that gout patient merges obesity.Because the hypertension therapeutic medicine often uses the antihypertensive diuretic agent, can suppress urate excretion, and uric acid level is raise, this point must be noted that.

The traditional Chinese medical science thinks that gout belongs to the arthromyodynia category, and is in close relations with arthralgia aggravated by cold, migratory arthralgia.About this cause of disease, " bright doctor's fingers and palms " volume six: " big rate is heated because of blood, from boiling, or relates to the cold wet cold of getting that is subjected to, and the warm blood then dirty tears of coagulating of must trembling with fear must not move, so have a pain." or because of internal injury, deficiency of both QI and blood, affection of exogenous wind-cold or the stagnant meridians of damp-phlegm YIN-fire stream.Disease is seen extremity, or back severe pain, again with refer to that toe joint swells and ache, deformity is for seeing more." the Zhang Shi doctor is logical ": " gout one card, the harmful wind of Miraculous Pivot meaning, the numbness of " element is asked " meaning, " gold is deficient " name is said severe and migratory arthralgia, the severe and migratory arthralgia of renaming later age." doctor slightly the six scripts gout " sets forth this disease and controls meaning: " light arthralgia then, the migratory arthralgia caused by wind extremity are difficult to change one's position, and podomere is red or swollen; Very then all over body scrofula piece, or swollen as gourd, or pain is as pulling quiet play at night in daytime.

The traditional Chinese medical science adopts this disease of decoction for the treatment of clearing away heat and eliminating dampness, diffusing impediment and relieving pain, channels sootheing and network vessel quickening, liver and kidney tonifying.

Summary of the invention

The Chinese medicine composition that the purpose of this invention is to provide a kind of gout.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition of gout, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Rhizoma Atractylodis 5-15 part Radix Cyathulae 5-20 part Semen Coicis 20-50 part

Gypsum Fibrosum 14-30 part Radix Gentianae Macrophyllae 20-40 part Aspongopus 10-30 part

Caulis Spatholobi 10-30 part Fructus Chaenomelis 2-12 part Pericarpium Citri Reticulatae 5-20 part

Bulbus Fritillariae Cirrhosae 10-30 part Rhizoma Polygoni Cuspidati 20-40 part Poria 10-30 part

Rhizoma Alismatis 10-30 part Caulis et folium gaultheriae yunnanensis 10-30 part Cortex Moutan 20-40 part

Fructus Corni 20-50 part Rhizoma Dioscoreae 20-50 part Herba Cistanches 10-30 part

Semen Cuscutae 10-30 part Radix Morindae Officinalis 10-20 part

Effective ingredient is preferably made by weight by following raw materials according:

30 parts of 15 parts of Semen Coiciss of 12 portions of Radix Cyathulaes of Rhizoma Atractylodis

20 parts of 30 portions of Aspongopuss of 24 portions of Radix Gentianae Macrophyllae of Gypsum Fibrosum

15 parts of 10 parts of Pericarpium Citri Reticulataes of 20 portions of Fructus Chaenomeliss of Caulis Spatholobi

15 parts in 30 parts of Poria of 15 parts of Rhizoma Polygoni Cuspidati of Bulbus Fritillariae Cirrhosae

30 parts of 25 parts of Cortex Moutans of 15 parts of Caulis et folium gaultheriae yunnanensiss of Rhizoma Alismatis

25 parts of 40 parts of Herba Cistanches of 35 portions of Rhizoma Dioscoreaes of Fructus Corni

12 parts of 18 parts of Radix Morindae Officinaliss of Semen Cuscutae

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) gypsum powder is broken into impalpable powder;

(2) Aspongopus, Cortex Moutan, Caulis et folium gaultheriae yunnanensis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Rhizoma Atractylodis, Radix Cyathulae, Semen Coicis, Radix Gentianae Macrophyllae, Caulis Spatholobi, Fructus Chaenomelis, Pericarpium Citri Reticulatae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygoni Cuspidati, Poria, Rhizoma Alismatis, Fructus Corni, Rhizoma Dioscoreae, Herba Cistanches, Semen Cuscutae, Radix Morindae Officinalis decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has removing damp-heat, and the effect of promoting blood circulation to remove obstruction in the collateral is used for the redness and swelling of joints that gout causes due to the dampness and heat stasis, burning pain, diseases such as joint stuffiness.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1 Chinese medicinal composition granules of the present invention

(1) gypsum powder is broken into impalpable powder;

(2) Aspongopus, Cortex Moutan, Caulis et folium gaultheriae yunnanensis, with 60% alcohol reflux secondary, each one hour, gradation filtered, it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Rhizoma Atractylodis, Radix Cyathulae, Semen Coicis, Radix Gentianae Macrophyllae, Caulis Spatholobi, Fructus Chaenomelis, Pericarpium Citri Reticulatae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygoni Cuspidati, Poria, Rhizoma Alismatis, Fructus Corni, Rhizoma Dioscoreae, Herba Cistanches, Semen Cuscutae, Radix Morindae Officinalis decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds dextrin 1000g, lactose 800g, mixing, with 75% ethanol wet granulation promptly.

Embodiment 2 Chinese medicinal composition capsules agent of the present invention

(1) gypsum powder is broken into impalpable powder;

(2) Aspongopus, Cortex Moutan, Caulis et folium gaultheriae yunnanensis, with 60% alcohol reflux secondary, each one hour, gradation filtered, it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Rhizoma Atractylodis, Radix Cyathulae, Semen Coicis, Radix Gentianae Macrophyllae, Caulis Spatholobi, Fructus Chaenomelis, Pericarpium Citri Reticulatae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygoni Cuspidati, Poria, Rhizoma Alismatis, Fructus Corni, Rhizoma Dioscoreae, Herba Cistanches, Semen Cuscutae, Radix Morindae Officinalis decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3 Chinese medicine composition tablets of the present invention

(1) Gypsum Fibrosum 300g is ground into impalpable powder;

(2) Aspongopus,, Cortex Moutan, Caulis et folium gaultheriae yunnanensis, with 60% alcohol reflux secondary, each one hour, gradation filtered, it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Rhizoma Atractylodis, Radix Cyathulae, Semen Coicis, Radix Gentianae Macrophyllae, Caulis Spatholobi, Fructus Chaenomelis, Pericarpium Citri Reticulatae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygoni Cuspidati, Poria, Rhizoma Alismatis, Fructus Corni, Rhizoma Dioscoreae, Herba Cistanches, Semen Cuscutae, Radix Morindae Officinalis decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, add starch 300g, microcrystalline Cellulose 200g is with 70% ethanol wet granulation, and tabletting, coating are promptly.

Claims (4)

1, a kind of Chinese medicine composition of gout is by effective ingredient and/or made in pharmaceutically acceptable year, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Rhizoma Atractylodis 5-15 part Radix Cyathulae 5-20 part Semen Coicis 20-50 part

Gypsum Fibrosum 14-30 part Radix Gentianae Macrophyllae 20-40 part Aspongopus 10-30 part

Caulis Spatholobi 10-30 part Fructus Chaenomelis 2-12 part Pericarpium Citri Reticulatae 5-20 part

Bulbus Fritillariae Cirrhosae 10-30 part Rhizoma Polygoni Cuspidati 20-40 part Poria 10-30 part

Rhizoma Alismatis 10-30 part Caulis et folium gaultheriae yunnanensis 10-30 part Cortex Moutan 20-40 part

Fructus Corni 20-50 part Rhizoma Dioscoreae 20-50 part Herba Cistanches 10-30 part

Semen Cuscutae 10-30 part Radix Morindae Officinalis 10-20 part.

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

30 parts of 15 parts of Semen Coiciss of 12 portions of Radix Cyathulaes of Rhizoma Atractylodis

20 parts of 30 portions of Aspongopuss of 24 portions of Radix Gentianae Macrophyllae of Gypsum Fibrosum

15 parts of 10 parts of Pericarpium Citri Reticulataes of 20 portions of Fructus Chaenomeliss of Caulis Spatholobi

15 parts in 30 parts of Poria of 15 parts of Rhizoma Polygoni Cuspidati of Bulbus Fritillariae Cirrhosae

30 parts of 25 parts of Cortex Moutans of 15 parts of Caulis et folium gaultheriae yunnanensiss of Rhizoma Alismatis

25 parts of 40 parts of Herba Cistanches of 35 portions of Rhizoma Dioscoreaes of Fructus Corni

12 parts of 18 parts of Radix Morindae Officinaliss of Semen Cuscutae.

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) gypsum powder is broken into impalpable powder;

(2) Aspongopus, Cortex Moutan, Caulis et folium gaultheriae yunnanensis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Rhizoma Atractylodis, Radix Cyathulae, Semen Coicis, Radix Gentianae Macrophyllae, Caulis Spatholobi, Fructus Chaenomelis, Pericarpium Citri Reticulatae, Bulbus Fritillariae Cirrhosae, Rhizoma Polygoni Cuspidati, Poria, Rhizoma Alismatis, Fructus Corni, Rhizoma Dioscoreae, Herba Cistanches, Semen Cuscutae, Radix Morindae Officinalis decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.