CN103405582A - Traditional Chinese medicine composition for improving joint gall of rheumatoid arthritis - Google Patents
Traditional Chinese medicine composition for improving joint gall of rheumatoid arthritis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for improving joint gall of rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicine comprises the following raw materials: shinyleaf pricklyash root, kadsura longepedunculata, cortex acanthopanacis, tinospora sinensis merr, clematis chinensis, cissus pteroclada hayata, sargentodoxa cuneata and Chinese starjasmine stem, and is applied to joint gall caused by wind, cold, wet, phlegm and blood stasis obstruction of meridians and collaterals. The effective constituents of the traditional Chinese medicine composition provided by the invention are the following raw materials: shinyleaf pricklyash root, kadsura longepedunculata, cortex acanthopanacis, tinospora sinensis merr, clematis chinensis, cissus pteroclada hayata, sargentodoxa cuneata and Chinese starjasmine stem. The traditional Chinese medicine composition has a remarkable curative effect on the aspect of improving joint gall of the rheumatoid arthritis, and the effect is superior to that of the prior art.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition that improves the rheumatoid arthritis arthralgia and preparation method thereof.
Background technology
Rheumatoid arthritis (rheumatoid arthritis, RA) is a kind of general autoimmune disease of aggressivity arthritis as main manifestations of take.Primary disease is multiple with the women.The about 1:3 of the ill ratio of men and women.RA can betide any age, take 30～50 years old as the morbidity peak.The RA prevalence in China mainland area is about 0.2%-0.4%.Primary disease shows as take the little joint involvement such as both hands and carpal joint and is main symmetry, persistence polyarthritis.Pathological manifestations is that chronic inflammatory disease, the pannus of synovium of joint forms, and cartilage and the osteoclasia in joint occur, finally can cause joint deformity and afunction.If without regular treatment, approximately 75% patient occurred maimed in 3 years.
The purpose for the treatment of rheumatoid arthritis is to control the state of an illness, improves function of joint and prognosis.
Traditional NSAID (non-steroidal anti-inflammatory drug) and improve state of an illness antirheumatic as main is still take in the at present treatment of rheumatoid arthritis, and intractable rheumatoid arthritis is used to low dose of glucocorticoid.Enter 21 century by biology the biological preparation that genetic engineering is produced magnetic target therapy arise at the historic moment, the biological preparation that can treat RA mainly comprises tumor necrosis factor (TNF)-alpha-2 antagonists, interleukin (IL)-l and IL-6 antagonist, IDEC-C2B8 and the agent of T cell co-stimulatory signal suppressing etc., but due to its somewhat expensive, clinical practice is restricted.Still there are in addition immunologic purging, stem cell transplantation and T cell vaccine effective to the alleviation possibility of RA, but are only applicable to small number of patients, still need further clinical observation.
In clinical application, treatment for rheumatoid arthritis, although use NSAID (non-steroidal anti-inflammatory drug) and improve state of an illness antirheumatic, the state of an illness improves, but still leave over the symptom swollen and ache repeatedly in the part joint, can not alleviate fully for a long time, and the untoward reaction such as gastrointestinal reaction, hepatic and renal function injure occur in the process of Long-term taking medicine.How to alleviate rheumatoid arthritis patients arthralgia repeatedly, reduce the goal in research that drug side effect becomes us.
Because the untoward reaction of western medical treatment is more, more patient is partial to and uses the Chinese traditional treatment rheumatoid arthritis.Chinese patent CN201210186089.6 " a kind of Chinese medicinal ointment for the treatment of rheumatic arthritis " discloses the formula that uses 15 flavor medical materials to form, and CN200510045203.3 " a kind of capsule for unblocking collaterals to treat arthritis " has been used 25 flavor medicines to form the formula for the treatment of rheumatic arthritis.These prescriptions are used flavour of a drug more, and rare medicinal herbs is arranged, and patient's long-term taking medical expense is very large." the routine observation of curative effect of Aconitum carmichjaelii Debx. Tonga flavor treatment rheumatoid arthritis 35 " (being published in " the Sichuan traditional Chinese medical science " the 24th the 1st phase of volume in 2006), the case observation that adds flavor Aconiti Decoction treatment rheumatoid arthritis by taking is disclosed." the medication Frequence Analysis of compound of Chinese medicine zoopery rheumatoid arthritis " (being published in the 30th the 3rd phase of volume of " Hunan University of Traditional Chinese Medicine's journal " March in 2010), classification by the Chinese medicine compound to 74 treatment rheumatoid arthritis gathers, the curative effect of finding Chinese medicine in treating rheumatoid arthritis obtains more and more certainly than doctor trained in Western medicine, in all kinds of pattern of syndrome, the more medicine of medicine frequency used is very close.In 74 groups of compound recipes, plan side is in the great majority certainly.Because though the actual clinical case has intermingling cold and heat, great majority or take partially cold or partial heat as main, the very large uncertainty of the method for the treatment of choosing side of the side of plan existence, may lack repeatability certainly.In the rheumatoid arthritis Chinese prescription used at present, mostly be furnished with the flavour of a drug with mild toxicity or toxicity, long-term taking orally easily causes toxicity to accumulate, and injures interior internal organs, if use medicated wine to be coated with outward, easily volatilization, curative effect is not lasting.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition that improves the rheumatoid arthritis arthralgia;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method of improving the rheumatoid arthritis arthralgia.
The objective of the invention is to realize by following technical scheme:
The described Chinese medicine composition that improves the rheumatoid arthritis arthralgia of patent of the present invention, it is to be prepared from by the raw material that comprises following weight portion:
70-30 parts of Radix Zanthoxylis, 70-30 parts of Fructus Schisandrae Sphenantheraes, 50-10 parts of Cortex Acanthopanciss, 50-10 parts of Herba Lycopodii, 50-10 parts of Radix Clematidis, 50-10 parts of Cissus pteroclada Hayatas, 50-10 parts of Caulis Sargentodoxae, 50-10 parts of Caulis Trachelospermis;
Preferably, be to be prepared from by the raw material that comprises following weight portion:
60-40 parts of Radix Zanthoxylis, 60-40 parts of Fructus Schisandrae Sphenantheraes, 40-20 parts of Cortex Acanthopanciss, 40-20 parts of Herba Lycopodii, 40-20 parts of Radix Clematidis, 40-20 parts of Cissus pteroclada Hayatas, 40-20 parts of Caulis Sargentodoxae, 40-20 parts of Caulis Trachelospermis;
More preferably, be to be prepared from by the raw material that comprises following weight portion:
50 parts of Radix Zanthoxylis, 50 parts of Fructus Schisandrae Sphenantheraes, 30 parts of Cortex Acanthopanciss, 30 parts of Herba Lycopodii, 30 parts of Radix Clematidis, 30 parts of Cissus pteroclada Hayatas, 30 parts of Caulis Sargentodoxae, 30 parts of Caulis Trachelospermis.
Below the crude drug source of Chinese medicine preparation of the present invention:
Radix Zanthoxyli is rutaceae Radix Zanthoxyli Zanthoxylum nitidum(Roxb.) dry root of DC..Record in " one one the 157th page of Chinese pharmacopoeia version in 2010.
Fructus Schisandrae Sphenantherae is the dry mature fruit of Magnoliacea plant schisandra chinensis Schisandra sphenanthera Rehd. Et Wils..Record in " one one the 227th page of Chinese pharmacopoeia version in 2010.
Cortex Acanthopancis is the dry root bark of Araliaceae acanthopanax gracilistylus Acanthopanax gracilistylus W. W. Smith.Record in " one one the 61st page of Chinese pharmacopoeia version in 2010.
Herba Lycopodii is that Menispermaceae Tinospora plant Tinospora sinensis Tinospora sinensis (Lour.) Merr. has rattan.Record in " the Sanitation Ministry medicine standard Tibetan medicine " first the 87th page.
Radix Clematidis is the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis chinensis Osbeck, Clematis hexapetala Clematis hexapetala Pall. or northeast clematis Clematis manshurica Rupr..Record in " one one the 234th page of Chinese pharmacopoeia version in 2010.
Cissus pteroclada Hayata is the stem of dicotyledon medicine vitaceae Cissus pteroclada Hayata.Record in " one one the 158th page of Chinese pharmacopoeia version in 1977.
Caulis Sargentodoxae is the dry rattan of plants of Lardizabalaceae Caulis Sargentodoxae Sargentodoxa cuneata (Oliv.) Rehd. et wils..Record in " one one the 19th page of Chinese pharmacopoeia version in 2010.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Record in " one one the 252nd page of Chinese pharmacopoeia version in 2010.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and its preparation method is as follows:
Scheme one: get whole 8 flavor medical materials, dipping extracts 3-4 time, adds medical material gross weight 2-4 50-90% alcohol dipping 12-60 hour doubly at every turn, incline and get supernatant, the squeezing medicinal residues, merge three supernatant and pressed liquor, filter, be concentrated into and be equivalent to 4～6 times of medical material gross weights, obtain active component.
Scheme two: get whole 8 flavor medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge three times extracting solution, filter, filtrate is concentrated into the extractum that 80 ℃ of lower relative densities are 1.10-1.30, add ethanol, make to contain the alcohol amount and be 40-70%, standing 12-24 hour, filter, when filtrate was concentrated into 80 ℃, relative density was the extractum of 1.10-1.25, obtained active component.
Scheme three: get whole 8 flavor medical materials, use 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is the medical material total amount doubly, extraction time is 1-4 hour, and merge extractive liquid, filters, when filtrate was concentrated into 60-80 ℃, relative density was the extractum of 1.10-1.25, obtained active component.
Scheme four: get whole 8 flavor medical materials, add 40%～60% the alcohol dipping 12～48 hours that is equivalent to 1～2 times of this 8 flavor medical material gross weight, then with 40%～60% ethanol, carry out percolation with the speed that accounts for raw material gross weight 0.2%～0.6% per minute, collection is equivalent to the percolate that this 8 flavor medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to 1～2 times that is equivalent to 8 flavor medical material gross weights, filter, obtain medicinal liquid A; Medicinal liquid A is active component.
Scheme five: get whole 8 flavor medical materials, adding the volume by volume concentration that is equivalent to 1～2 times of this 8 flavor medical material gross weight is 50%～56% alcohol dipping 24～36 hours, then with the ethanol that volume by volume concentration is 50%～56%, carry out percolation with the speed that accounts for raw material gross weight 0.3%～0.5% per minute, collection is equivalent to the percolate that this 8 flavor medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to 1～2 times that is equivalent to 8 flavor medical material gross weights, filter, obtain medicinal liquid A; Medicinal liquid A is active component.
The Chinese medicine composition that improves the rheumatoid arthritis arthralgia of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms.
For example, it can be prepared as various common exterior-applied formulations by one of following method:
Method 1: tincture
Get the 8 flavor medical materials such as Radix Zanthoxyli, Fructus Schisandrae Sphenantherae, Cortex Acanthopancis, Herba Lycopodii, Radix Clematidis, Cissus pteroclada Hayata, Caulis Sargentodoxae, Caulis Trachelospermi, dipping extracts 3-4 time, add medical material gross weight 2-4 50-90% alcohol dipping 12-60 hour doubly at every turn, incline and get supernatant, the squeezing medicinal residues, merge three supernatant and pressed liquor, filter, be concentrated into and be equivalent to 4～6 times of medical material gross weights, filter, packing, sealing, obtain the tincture of Chinese medicine composition of the present invention.
Method 2: ointment
Get Radix Zanthoxyli, Fructus Schisandrae Sphenantherae, Cortex Acanthopancis, Herba Lycopodii, Radix Clematidis, Cissus pteroclada Hayata, Caulis Sargentodoxae, the 8 flavor medical materials such as Caulis Trachelospermi, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge three times extracting solution, filter, filtrate is concentrated into the extractum that 80 ℃ of lower relative densities are 1.10-1.30, add ethanol, make to contain the alcohol amount and be 40-70%, standing 12-24 hour, filter, when filtrate was concentrated into 80 ℃, relative density was the extractum of 1.10-1.25, dry, pulverize, with appropriate water-soluble base, coordinate, stir, obtain the ointment of Chinese medicine composition of the present invention.
Method 3: gel rubber plaster unguentum
Get the 8 flavor medical materials such as Radix Zanthoxyli, Fructus Schisandrae Sphenantherae, Cortex Acanthopancis, Herba Lycopodii, Radix Clematidis, Cissus pteroclada Hayata, Caulis Sargentodoxae, Caulis Trachelospermi, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is the medical material total amount doubly, extraction time is 1-4 hour, merge extractive liquid,, filter, when filtrate was concentrated into 60-80 ℃, relative density was the extractum of 1.10-1.25; After extractum and appropriate hydrophilic matrix are mixed, be coated with cream lid lining, section, obtain the gel rubber plaster unguentum of Chinese medicine composition of the present invention.
Method 4: lotion
Get the 8 flavor medical materials such as Radix Zanthoxyli, Fructus Schisandrae Sphenantherae, Cortex Acanthopancis, Herba Lycopodii, Radix Clematidis, Cissus pteroclada Hayata, Caulis Sargentodoxae, Caulis Trachelospermi, add 40%～60% the alcohol dipping 12～48 hours that is equivalent to 1～2 times of this 8 flavor medical material gross weight, then with 40%～60% ethanol, carry out percolation with the speed that accounts for raw material gross weight 0.2%～0.6% per minute, collection is equivalent to the percolate that this 8 flavor medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to 1～2 times that is equivalent to 8 flavor medical material gross weights, filter, obtain medicinal liquid A, medicinal liquid A is active component; In active component, add glycerol, make the lotion of Chinese medicine composition of the present invention.
Method 5: powder
Get the 8 flavor medical materials such as Radix Zanthoxyli, Fructus Schisandrae Sphenantherae, Cortex Acanthopancis, Herba Lycopodii, Radix Clematidis, Cissus pteroclada Hayata, Caulis Sargentodoxae, Caulis Trachelospermi, extracting in water 2-3 time, each amount of water is equivalent to 8-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filter, concentrated, add ethanol to make to contain the alcohol amount and be 50-70%, standing 12-48 hour, elimination precipitate, drying, pulverize, obtain the powder of Chinese medicine composition of the present invention.
Rheumatoid arthritis belongs to motherland's medical science " Bi condition " category, and ancient medicine thinks that the damp and hot heresy of wind and cold is the exopathogenic factor that rheumatoid arthritis occurs more, and insufficiency of vital energy and blood, battalion to defend imbalance be the important endogenous cause of ill of primary disease.The people of the Guangxi Yao nationality are because the place, residence is remote, thickly forested mountains, height above sea level, very cold humidity, rheumatic arthralgia are frequently-occurring disease, endemic diseases, and the precious jade doctor is referred to as " the wind enemy is sick " (precious jade name: buermgh kiex mun), treatment to this class disease, the precious jade medical conclusion various informative external therapy, abundant in content, determined curative effect, use directly, often can play the effect of getting instant result.
The applicant is on the basis of research tradition Chinese herbal medicine, and through test for many years, the precious jade medicine proved recipe from spreading, screen multiple formulations, found the good several drugs of primary disease therapeutic effect has been completed to the present invention.
Chinese medicine composition effective ingredient disclosed in this invention is to be prepared from by raw materials such as Radix Zanthoxyli, Fructus Schisandrae Sphenantherae, Cortex Acanthopancis, Herba Lycopodii, Radix Clematidis, Cissus pteroclada Hayata, Caulis Sargentodoxae, Caulis Trachelospermis.What in side, Radix Zanthoxyli belonged to precious jade medicine " five tigers " enters the mountain tiger, the removing toxic substances dehumidifying of dispeling the wind, promoting blood circulation and detumescence pain relieving; Herba Lycopodii, Radix Clematidis belong to nine Ns inner of green grass or young crops of precious jade medicine " nine Ns ", black nine Ns and open and close saturating key, expelling wind and removing dampness, soothing the channels and quicking the network vessels function; Caulis Sargentodoxae, Cissus pteroclada Hayata, Fructus Schisandrae Sphenantherae belong to that the inner Semen Arecae of precious jade medicine " 18 bore " bores, bore in four directions and bradawl has and passes away arteries and veins, the merit of expelling wind and activating blood circulation, promoting the circulation of QI to relieve pain; Caulis Trachelospermi belongs to " 72 wind " inner wall wind of climbing and has expelling wind and removing dampness, dredge the meridian passage, the effect of eliminating stasis to stop pain; Cortex Acanthopancis, precious jade name bar chucking, have liver and kidney tonifying, reducing swelling and alleviating pain.Expelling wind and removing dampness is played, promoting blood circulation to remove obstruction in the collateral, the merit of reducing swelling and alleviating pain altogether in top.Chinese medicine composition of the present invention to because of wind, cold, wet, expectorant is turbid, Yu Xue Bi resistance meridians, the joint caused significant curative effect that swollen and ache, can alleviate rapidly the rheumatoid arthritis patients arthralgia, reduce the endo-medicine consumption, avoid the untoward reaction such as gastrointestinal reaction, hepatic and renal function injure.
Chinese medicine composition of the present invention can also be used conventional method, makes Emulsion, patch, varnish, spray, liniment etc.
A kind of Chinese medicine composition that improves the rheumatoid arthritis arthralgia provided by the invention has the following advantages:
1, the present invention to because of wind, cold, wet, expectorant is turbid, Yu Xue Bi resistance meridians, joint caused inflammation and arthralgia have significant curative effect, and old trouble is for many years also had to same significant curative effect.
2, use chemical drugs fail to respond to any medical treatment or curative effect not remarkable, symptom does not disappear or disappears after incomplete rheumatoid arthritis arthralgia patient uses the present invention to treat, arthralgia, alleviate patient's misery rapidly.
3, external preparation of the present invention can be alleviated rapidly the rheumatoid arthritis patients arthralgia, reduces the endo-medicine consumption, avoids gastrointestinal reaction to reduce drug effect, and causes the untoward reaction such as hepatic and renal function injure.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are be used to the present invention rather than limitation of the present invention are described.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v means the volume ratio of solution.
Embodiment 1: the preparation of tincture
Get Radix Zanthoxyli 50g, Fructus Schisandrae Sphenantherae 50g, Cortex Acanthopancis 30g, Herba Lycopodii 30g, Radix Clematidis 30g, Cissus pteroclada Hayata 30g, Caulis Sargentodoxae 30g, Caulis Trachelospermi 30g, clean, break into coarse powder, 80% alcohol dipping 48 hours that adds 2 times of medical material gross weights, incline and get supernatant, 75% alcohol dipping 48 hours that adds again 2 times of medical material gross weights, incline and get supernatant, 70% alcohol dipping 24 hours that adds again 2 times of medical material gross weights, incline and get supernatant, the squeezing medicinal residues, merge three supernatant and pressed liquor, filter, be concentrated into and be equivalent to 6 times of medical material gross weights, filter, packing, sealing, obtain.
Embodiment 2: the preparation of tincture
Get Radix Zanthoxyli 40g, Fructus Schisandrae Sphenantherae 60g, Cortex Acanthopancis 20g, Herba Lycopodii 40g, Radix Clematidis 40g, Cissus pteroclada Hayata 40g, Caulis Sargentodoxae 10g, Caulis Trachelospermi 30g, clean, break into coarse powder, 90% alcohol dipping 60 hours that adds 4 times of medical material gross weights, incline and get supernatant, 70% alcohol dipping 48 hours that adds again 3 times of medical material gross weights, incline and get supernatant, 50% alcohol dipping 12 hours that adds again 2 times of medical material gross weights, incline and get supernatant, the squeezing medicinal residues, merge three supernatant and pressed liquor, filter, be concentrated into and be equivalent to 4 times of medical material gross weights, filter, packing, sealing, obtain.
Embodiment 3: the preparation of tincture
Get Radix Zanthoxyli 30g, Fructus Schisandrae Sphenantherae 60g, Cortex Acanthopancis 40g, Herba Lycopodii 40g, Radix Clematidis 20g, Cissus pteroclada Hayata 30g, Caulis Sargentodoxae 30g, Caulis Trachelospermi 20g, clean, break into coarse powder, 90% alcohol dipping 54 hours that adds 4 times of medical material gross weights, incline and get supernatant, 75% alcohol dipping 36 hours that adds again 3 times of medical material gross weights, incline and get supernatant, 60% alcohol dipping 12 hours that adds again 2 times of medical material gross weights, incline and get supernatant, the squeezing medicinal residues, merge three supernatant and pressed liquor, filter, be concentrated into and be equivalent to 5 times of medical material gross weights, filter, packing, sealing, obtain.
Embodiment 4: the preparation of ointment
Get Radix Zanthoxyli 60g, Fructus Schisandrae Sphenantherae 40g, Cortex Acanthopancis 40g, Herba Lycopodii 20g, Radix Clematidis 40g, Cissus pteroclada Hayata 20g, Caulis Sargentodoxae 40g, Caulis Trachelospermi 20g, extracting in water three times, each amount of water is equivalent to 10 times of medical material gross weight, 2 hours extraction times for the first time, 1 hour extraction time for the second time, 1 hour extraction time for the third time, merge three times extracting solution, filter, it is 1.10(80 ℃ that filtrate is concentrated into relative density), add ethanol, making to contain the alcohol amount is 70%, standing 12 hours, filter, when filtrate was concentrated into 80 ℃, relative density was 1.25 extractum, dry, pulverize, standby.Get appropriate water-soluble base, after water-bath is dissolved, then add appropriate penetrating agent, stir.Above-mentioned substrate is progressively joined in standby fine powder, stir, after the ointment shape that congeals into, embedding, in ointment tube, obtains.
Embodiment 5: the preparation of ointment
Get Radix Zanthoxyli 55g, Fructus Schisandrae Sphenantherae 60g, Cortex Acanthopancis 40g, Herba Lycopodii 25g, Radix Clematidis 40g, Cissus pteroclada Hayata 35g, Caulis Sargentodoxae 35g, Caulis Trachelospermi 35g, extracting in water three times, each amount of water is equivalent to 6 times of medical material gross weight, 3 hours extraction times for the first time, 2 hours extraction times for the second time, 1 hour extraction time for the third time, merge three times extracting solution, filter, it is 1.30(80 ℃ that filtrate is concentrated into relative density), add ethanol, making to contain the alcohol amount is 40%, standing 24 hours, filter, when filtrate was concentrated into 80 ℃, relative density was 1.10 extractum, dry, pulverize, standby.Get appropriate water-soluble base, after water-bath is dissolved, then add appropriate penetrating agent, stir.Above-mentioned substrate is progressively joined in standby fine powder, stir, after the ointment shape that congeals into, embedding, in ointment tube, obtains.
Embodiment 6: the preparation of gel rubber plaster unguentum
Get Radix Zanthoxyli 30g, Fructus Schisandrae Sphenantherae 70g, Cortex Acanthopancis 10g, Herba Lycopodii 10g, Radix Clematidis 50g, Cissus pteroclada Hayata 50g, Caulis Sargentodoxae 20g, Caulis Trachelospermi 40g, add 80% alcohol reflux three times, each amount of alcohol added is 4 times of medical material total amount, extraction time was respectively 3 hours, 2 hours, 1 hour, merge extractive liquid,, filter, when filtrate was concentrated into 60 ℃, relative density was 1.25 extractum, obtained active component.
Active component adds the adjuvants such as appropriate adhesive, wetting agent, filler, stirs, and coats on back lining materials, obtains gel rubber plaster unguentum of the present invention.
Embodiment 7: the preparation of gel rubber plaster unguentum
Get Radix Zanthoxyli 65, Fructus Schisandrae Sphenantherae 65g, Cortex Acanthopancis 25g, Herba Lycopodii 25g, Radix Clematidis 30g, Cissus pteroclada Hayata 30g, Caulis Sargentodoxae 15g, Caulis Trachelospermi 15g, add twice of 40% alcohol reflux, each amount of alcohol added is 10 times of medical material total amount, extraction time was respectively 4 hours, 3 hours, merge extractive liquid,, filter, when filtrate was concentrated into 80 ℃, relative density was 1.10 extractum, obtained active component.
Active component adds the adjuvants such as appropriate adhesive, wetting agent, filler, stirs, and coats on back lining materials, obtains gel rubber plaster unguentum of the present invention.
Embodiment 8: the preparation of gel rubber plaster unguentum
Get Radix Zanthoxyli 55, Fructus Schisandrae Sphenantherae 55g, Cortex Acanthopancis 45g, Herba Lycopodii 45g, Radix Clematidis 15g, Cissus pteroclada Hayata 15g, Caulis Sargentodoxae 50g, Caulis Trachelospermi 50g, add 40% alcohol reflux three times, each amount of alcohol added is 8 times of medical material total amount, extraction time was respectively 3 hours, 3 hours, 2 hours, merge extractive liquid,, filter, when filtrate was concentrated into 70 ℃, relative density was 1.15 extractum, obtained active component.
Active component adds the adjuvants such as appropriate adhesive, wetting agent, filler, stirs, and coats on back lining materials, obtains gel rubber plaster unguentum of the present invention.
Embodiment 9: the preparation of lotion
Get Radix Zanthoxyli 70g, Fructus Schisandrae Sphenantherae 30g, Cortex Acanthopancis 50g, Herba Lycopodii 20g, Radix Clematidis 10g, Cissus pteroclada Hayata 30g, Caulis Sargentodoxae 50g, Caulis Trachelospermi 10g, adding the volume by volume concentration that is equivalent to 2 times of this 8 flavor medical material gross weights is 60% alcohol dipping 48 hours, then with the ethanol that volume by volume concentration is 60%, carry out percolation with the speed that accounts for raw material gross weight 0.2% per minute, collection is equivalent to the percolate of 10 times of amounts of this 8 flavor medical material gross weight, reclaim ethanol, be evaporated to 2 times that are equivalent to 8 flavor medical material gross weights, filter, filtrate, add 2g glycerol, mix, obtain lotion.
Embodiment 10: the preparation of lotion
Get Radix Zanthoxyli 55g, Fructus Schisandrae Sphenantherae 55g, Cortex Acanthopancis 45g, Herba Lycopodii 40g, Radix Clematidis 50g, Cissus pteroclada Hayata 10g, Caulis Sargentodoxae 50g, Caulis Trachelospermi 10g, adding the volume by volume concentration that is equivalent to 1 times of this 8 flavor medical material gross weight is 40% alcohol dipping 12 hours, then with the ethanol that volume by volume concentration is 40%, carry out percolation with the speed that accounts for raw material gross weight 0.6% per minute, collection is equivalent to the percolate of 5 times of amounts of this 8 flavor medical material gross weight, reclaim ethanol, be evaporated to 1 times that is equivalent to 8 flavor medical material gross weights, filter, filtrate, add 1.5g glycerol, mix, obtain lotion.
Embodiment 11: the preparation of powder
Get Radix Zanthoxyli 50g, Fructus Schisandrae Sphenantherae 40g, Cortex Acanthopancis 30g, Herba Lycopodii 50g, Radix Clematidis 20g, Cissus pteroclada Hayata 10g, Caulis Sargentodoxae 40g, Caulis Trachelospermi 50g, extracting in water three times, each amount of water is equivalent to 8 times of medical material gross weight, each extraction time was respectively 2 hours, 1 hour, 1 hour, merge extractive liquid,, filter, concentrated, adding ethanol to make to contain the alcohol amount is 70%, standing 12 hours, elimination precipitate, drying, pulverize, obtain the powder of Chinese medicine composition of the present invention.
Embodiment 12: the preparation of powder
Get Radix Zanthoxyli 30g, Fructus Schisandrae Sphenantherae 30g, Cortex Acanthopancis 10g, Herba Lycopodii 50g, Radix Clematidis 30g, Cissus pteroclada Hayata 50g, Caulis Sargentodoxae 50g, Caulis Trachelospermi 30g, extracting in water twice, each amount of water is equivalent to 12 times of medical material gross weight, each extraction time is 3 hours, merge extractive liquid,, filter, concentrated, adding ethanol to make to contain the alcohol amount is 50%, standing 48 hours, elimination precipitate, drying, pulverize, obtain the powder of Chinese medicine composition of the present invention.
Clinical treatment is summed up
The selection of 1 case
1.1 criteria for classification: the rheumatoid arthritis criteria for classification that adopts American Rheumatism Association's revision in 1987
1.1.1 at least 1 hour (>=6 week) of deadlock morning
1.1.2 3 or 3 above hinge area swollen joints (>=6 week)
1.1.3 close between wrist, metacarpophalangeal joints or near-end refer to. joint swollen (>=6 week)
1.1.4 symmetry swollen joint (>=6 week)
1.1.5 subcutaneous nodule
1.1.6 the both hands X-ray changes
1.1.7 the rheumatoid factor positive (titre>1:32)
All patients all meet in above-mentioned 7 more than 4 or 4
1.2 inclusive criteria: 1. allly meet simultaneously above-mentioned doctor trained in Western medicine criteria for classification, TCM syndrome diagnostic criteria patient; 2. age 18-65 year person; 3. function of joint I-III level person; 4. be ready to accept 2 all therapists; 5. signature enters clinical research Informed Consent Form person.
The function of joint grade scale:
I level functional status is intact, and daily routines are unrestricted.
II level energy normal activity, but have one or more joint motions limited or uncomfortable.
III level joint motion is limited, can only be competent at a part or the general occupational task that grosses incompetence, or can not take care of number one well.
The IV level is most of or completely lose mobility, and life can't be taken care of oneself.
1.3 exclusion standard: 1. do not meet above-mentioned criteria for classification and inclusive criteria; 2. accept other relevant treatment, may affect this research effect index observer; 3. merge the serious life-threatening primary diseases such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system, diabetes and psychotic; 4. the age is under-18s or over-65s patient; 5. gestation or age of sucking the patient; 6. patients with terminal, joint severe deformities, function of joint IV level person; 7. merge other autoimmune disease, serious other rheumatism patients such as knee osteoarthritis; 8. to drug allergy person used; 9. local skin ulceration, sepage, the pus infections is arranged and the skin infectious disease patient is arranged; 10. can not accept 2 all therapists.
2 medicines
Embodiment 1-3: press the preparation of embodiment method
Meloxicam tablet: purchased from Shanghai Boehringer Ingelheim pharmaceutcal corporation, Ltd
Methotrexate sheet: purchased from Shanghai Sine Pharmaceutical Co., Ltd.
3 treatment groupings
Treatment group: the medicine that uses the embodiment of the present invention 1.
Matched group: take meloxicam tablet, methotrexate sheet.
4 Therapeutic Method
The embodiment group: the medicine of the embodiment of the present invention 1, adopt the absorb the drug mode of rear hot compress of towel.Every day 1 time, each 20 minutes, 7 was 1 course for the treatment of, was used in conjunction for 2 courses for the treatment of.
Matched group: meloxicam tablet 15mg, every day 1 time; Methotrexate sheet 10mg, 1 time weekly.
5 observation index
Tenderness is closed joint number, is swollen and ache and close joint number, erythrocyte sedimentation rate
Observe totally 28, joint: comprise both shoulders, duplex, two wrist, both hands metacarpophalangeal joints, both hands proximal interphalangeal joint, double knee joint
6 evaluation methodologys:
Improvement disease activity standard (3 variable) [modified disease activity score (3 variables) is called for short DAS28-3] the judgement conditions of patients activeness that adopts European rheumatism alliance to formulate.
DAS28-3 scores with 28 joints: comprise both shoulders, duplex, two wrist, both hands metacarpophalangeal joints, both hands proximal interphalangeal joint, double knee joint.
DAS28-3=(0.56 * tenderness number+0.28 * swelling number+0.70 * erythrocyte sedimentation rate) * 1.08+0.16
Catabasis DAS28-3≤2.6 minute
Low 2.6 minutes<DAS28-3 of activeness≤3.2 minutes
3.2 minutes<DAS28-3 of moderate activity≤5.1 minutes
High activeness DAS28-3 > 5.1 minutes.
7 results
| Group | Number of cases | Before treatment | After treatment |
| Embodiment 1 | 30 | 5.12±0.78 | 2.71±0.69*△ |
| Matched group 1 | 30 | 5.16±0.81 | 3.53±0.76* |
Annotate: * means to compare before the treatment of this group, P<0.05; △ means treatment group and matched group group relatively, P<0.05.
Upper table result shows: after embodiment 1, treatment of control group, the state of an illness all is improved, and embodiment 1 compares with the effect after treatment of control group, has significant difference (P<0.05).
Result shows: Chinese medicine composition provided by the invention has and improves the effect that rheumatoid arthritis knuckle swells and ache, and effect is better than matched group, compares with matched group, has significant difference.
Model case
1, Wang, the female, 56 years old, the Liujiang man of Liuzhou City, in May, 2012 is medical, and extremities joint swelled and ache more than 3 years repeatedly, once took the treatments such as methotrexate, meloxicam, but still have the both hands proximal interphalangeal joint to swell and ache, be coated on affected part through the medicine of the embodiment of the present invention 4, both hands proximal interphalangeal joint basic disappearance of swelling and ache after 2 weeks for the treatment of.
2, Zhang, the female, 52 years old, people from Liuzhou, in March, 2012 is medical, extremities joint swelled and ache more than 5 years repeatedly, previously once tossed about in bed Guangxi Duo Jia hospital and clinic treatment, after treatment, the state of an illness is controlled and still can, but still leave over right carpal joint swelling and pain, use the medicine hot compress of the embodiment of the present invention 6 affected part of apting, treat 3 times after symptom namely improve.
3, Wei, the female, 48 years old, people from Liuzhou, in JIUYUE, 2012 is medical, and extremities joint swelled and ache more than 6 years repeatedly, once used the treatments such as leflunomide, sulfasalazine, oxychloroquine, now still have two knee joints, right ankle to swell and ache, limitation of activity, symptom is alleviated substantially after the embodiment of the present invention 9 medicine heating foam washings are treated 10 days.
4, the Qin, man, 60 years old, people from Rong'an, Guangxi, in JIUYUE, 2012 is medical, and extremities joint swelled and ache more than 10 years repeatedly, once uses the treatments such as prednisone, methotrexate for many years, still has left shoulder pain, limitation of activity, press 7 days rear left shoulder pains for the treatment of through the medicine hot compress of the embodiment of the present invention 11 and disappear, and activity freely.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. Chinese medicine composition that improves the rheumatoid arthritis arthralgia is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
70-30 parts of Radix Zanthoxylis, 70-30 parts of Fructus Schisandrae Sphenantheraes, 50-10 parts of Cortex Acanthopanciss, 50-10 parts of Herba Lycopodii, 50-10 parts of Radix Clematidis, 50-10 parts of Cissus pteroclada Hayatas, 50-10 parts of Caulis Sargentodoxae, 50-10 parts of Caulis Trachelospermis.
2. Chinese medicine composition according to claim 1 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
60-40 parts of Radix Zanthoxylis, 60-40 parts of Fructus Schisandrae Sphenantheraes, 40-20 parts of Cortex Acanthopanciss, 40-20 parts of Herba Lycopodii, 40-20 parts of Radix Clematidis, 40-20 parts of Cissus pteroclada Hayatas, 40-20 parts of Caulis Sargentodoxae, 40-20 parts of Caulis Trachelospermis.
3. Chinese medicine composition according to claim 1 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
50 parts of Radix Zanthoxylis, 50 parts of Fructus Schisandrae Sphenantheraes, 30 parts of Cortex Acanthopanciss, 30 parts of Herba Lycopodii, 30 parts of Radix Clematidis, 30 parts of Cissus pteroclada Hayatas, 30 parts of Caulis Sargentodoxae, 30 parts of Caulis Trachelospermis.
4. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that its active component is prepared from by the following method:
Get whole 8 flavor medical materials, dipping extracts 3-4 time, adds medical material gross weight 2-4 50-90% alcohol dipping 12-60 hour doubly at every turn, incline and get supernatant, the squeezing medicinal residues, merge three supernatant and pressed liquor, filter, be concentrated into and be equivalent to 4～6 times of medical material gross weights, obtain.
5. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that its active component is prepared from by the following method:
Get whole 8 flavor medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge three times extracting solution, filter, filtrate is concentrated into the extractum that 80 ℃ of lower relative densities are 1.10-1.30, add ethanol, make to contain the alcohol amount and be 40-70%, standing 12-24 hour, filter, when filtrate was concentrated into 80 ℃, relative density was the extractum of 1.10-1.25, obtained.
6. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that its active component is prepared from by the following method:
Get whole 8 flavor medical materials, use 40-80% alcohol reflux 2-3 time, doubly, extraction time is 1-4 hour to the 4-10 that each ethanol consumption is the medical material total amount, and merge extractive liquid,, filter, and when filtrate was concentrated into 60-80 ℃, relative density was the extractum of 1.10-1.25, obtained.
7. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that its active component is prepared from by the following method:
Get whole 8 flavor medical materials, add 40%～60% the alcohol dipping 12～48 hours that is equivalent to 1～2 times of this 8 flavor medical material gross weight, then with 40%～60% ethanol, carry out percolation with the speed that accounts for raw material gross weight 0.2%～0.6% per minute, collection is equivalent to the percolate that this 8 flavor medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to 1～2 times that is equivalent to 8 flavor medical material gross weights, filter, obtain medicinal liquid A; Medicinal liquid A is active component.
8. Chinese medicine composition according to claim 7 is characterized in that its active component is prepared from by the following method:
Get whole 8 flavor medical materials, adding the volume by volume concentration that is equivalent to 1～2 times of this 8 flavor medical material gross weight is 50%～56% alcohol dipping 24～36 hours, then with the ethanol that volume by volume concentration is 50%～56%, carry out percolation with the speed that accounts for raw material gross weight 0.3%～0.5% per minute, collection is equivalent to the percolate that this 8 flavor medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to 1～2 times that is equivalent to 8 flavor medical material gross weights, filter, obtain medicinal liquid A; Medicinal liquid A is active component.
9. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that its powder is prepared from by the following method:
Get whole 8 flavor medical materials, extracting in water 2-3 time, each amount of water is equivalent to 8-12 times of medical material gross weight, and each extraction time is 1-3 hour, merge extractive liquid,, filter, concentrated, add ethanol to make to contain the alcohol amount and be 50-70%, standing 12-48 hour, the elimination precipitate, dry, pulverize, and obtains.
10. Chinese medicine preparation that improves the rheumatoid arthritis arthralgia, comprise the Chinese medicine composition for the treatment of damp-heat type osteoarthritis of any one in claim 1～3 and pharmaceutically acceptable carrier.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103877329A (en) * | 2014-04-16 | 2014-06-25 | 李国宣 | Chinese traditional medicine composition for curing sciatica and lumbar muscle strain and preparation method of composition |
| CN104740402A (en) * | 2015-04-09 | 2015-07-01 | 包月妹 | Medicinal composition for treating rheumatoid arthritis |
| CN105412416A (en) * | 2015-12-22 | 2016-03-23 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine lotion for treating rheumatic arthritis and preparation method thereof |
| CN110638913A (en) * | 2019-10-11 | 2020-01-03 | 广西中医药大学 | Yao medicine composition for treating rheumatoid arthritis and preparation method and application thereof |
| CN112933205A (en) * | 2021-01-21 | 2021-06-11 | 贵州溥正生物科技有限公司 | Pharmaceutical composition for treating osteoarthritis and preparation method thereof |
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| CN1616058A (en) * | 2004-09-28 | 2005-05-18 | 叶耀良 | Chinese medicine compound rheumatism preparation for improving bioavailability and medicine effect and preparing method |
| CN102048965A (en) * | 2010-12-08 | 2011-05-11 | 惠州市欧野科技有限公司 | Medicinal knee belt for treating rheumatalgia |
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- 2013-08-07 CN CN201310340795.6A patent/CN103405582B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1616058A (en) * | 2004-09-28 | 2005-05-18 | 叶耀良 | Chinese medicine compound rheumatism preparation for improving bioavailability and medicine effect and preparing method |
| CN102048965A (en) * | 2010-12-08 | 2011-05-11 | 惠州市欧野科技有限公司 | Medicinal knee belt for treating rheumatalgia |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877329A (en) * | 2014-04-16 | 2014-06-25 | 李国宣 | Chinese traditional medicine composition for curing sciatica and lumbar muscle strain and preparation method of composition |
| CN104740402A (en) * | 2015-04-09 | 2015-07-01 | 包月妹 | Medicinal composition for treating rheumatoid arthritis |
| CN105412416A (en) * | 2015-12-22 | 2016-03-23 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine lotion for treating rheumatic arthritis and preparation method thereof |
| CN110638913A (en) * | 2019-10-11 | 2020-01-03 | 广西中医药大学 | Yao medicine composition for treating rheumatoid arthritis and preparation method and application thereof |
| CN112933205A (en) * | 2021-01-21 | 2021-06-11 | 贵州溥正生物科技有限公司 | Pharmaceutical composition for treating osteoarthritis and preparation method thereof |
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