CN106138709A - A kind of glossy ganoderma composition with treatment gout effect - Google Patents

A kind of glossy ganoderma composition with treatment gout effect Download PDF

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Publication number
CN106138709A
CN106138709A CN201610633544.0A CN201610633544A CN106138709A CN 106138709 A CN106138709 A CN 106138709A CN 201610633544 A CN201610633544 A CN 201610633544A CN 106138709 A CN106138709 A CN 106138709A
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parts
grass
filtrate
ganoderma
glossy ganoderma
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CN201610633544.0A
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Chinese (zh)
Inventor
毛景华
朱健
蔡超婧
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WUYISHAN YUANSHENGTAI BIOTECHNOLOGY CO Ltd
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WUYISHAN YUANSHENGTAI BIOTECHNOLOGY CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention provides a kind of glossy ganoderma composition with treatment gout effect, be composed of the following raw materials by weight: black ant 15 25 parts, the Radix Astragali 10 20 parts, grass summer in winter grass 5 15 parts, Ganoderma 25 35 parts, Rhizoma Polygonati 10 20 parts, Radix Persicae 5 10 parts, Testa arachidis hypogaeae 5 12 parts, Herba Duchesneae Indicae 5 10 parts, Herba Taraxaci 7 12 parts.Glossy ganoderma composition prepared by the present invention has effect that treatment is ventilated, and preparation method is simple, edible safety.

Description

A kind of glossy ganoderma composition with treatment gout effect
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of glossy ganoderma composition with treatment gout effect.
Background technology
Ganoderma is On Polyporaceae Ganoderma also known as Lin Zhongling, fine jade precious (formal name used at school: Ganoderma Lucidum Karst) Sporophore.There is effect of invigorating QI and tranquilization, relieving cough and asthma, for dizziness sleeplessness, shortness of breath and palpitation, neurasthenia, asthenia cough with asthma, prolong Effect that year lengthens one's life.
Gout is also known as hyperuricemia, and sickness rate is high, cure difficult, recurrent exerbation, belongs to the generation that disorders of purine metabolism causes Thanking property disease.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker, and its clinical characters is hyperuricemia and thus The gouty acute arthritis recurrent exerbation caused, tophaceous deposition, tophaceous chronic arthritis and joint deformity etc., to close Joint redness, burning pain, recurrent exerbation, joint motion are dumb for main clinical manifestation.Often involve kidney and cause chronic interstitial kidney Scorching and uric acid kidney stones is formed.
The Western medicine being currently used for treating gout mainly has: colchicine, Phenylbutazone or crovaril, indometacin, Bu Luo Fragrant (ibvprofen, ibuprofen) etc..But said medicine can only stablize the state of an illness mostly, it is impossible to radical cure gout；Also can draw Play serious side effect and cause the infringement of hepatic and renal function；Even if Emergent therapy effectively can not recur by symptom management, and can produce Raw drug resistance and repellence, even there will be leukopenia, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system System, aplastic anemia, cause the complication such as diabetes.Increasing expert thinks: go out from the organic conception of the traditional Chinese medical science Send out, treat with Chinese medicine integral syndrome differentiation, the good footpath of another bar for the treatment of gout of can yet be regarded as；The not only toxic and side effects of Chinese medicine itself Greatly reduce, and Western medicine dose can be reduced, overcome and take merely the huge toxic and side effects that Western medicine is brought for a long time.But at present The Chinese patent medicine treating gout on market is few, and curative effect is the most more a lack of, and patient still can only be by taking toxic and side effects in a large number The state of an illness stablized by bigger Western medicine.
Summary of the invention
It is an object of the invention to provide a kind of glossy ganoderma composition with treatment gout effect.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of glossy ganoderma composition with treatment gout effect, is composed of the following raw materials by weight: black ant 15-25 part, Radix Astragali 10- 20 parts, winter grass summer grass 5-15 part, Ganoderma 25-35 part, Rhizoma Polygonati 10-20 part, Radix Persicae 5-10 part, Testa arachidis hypogaeae 5-12 part, Herba Duchesneae Indicae 5- 10 parts, Herba Taraxaci 7-12 part.
Preferably, it is composed of the following raw materials by weight: black ant 20 parts, the Radix Astragali 15 parts, grass summer in winter grass 10 parts, Ganoderma 30 parts, Rhizoma Polygonati 15 parts, Radix Persicae 8 parts, Testa arachidis hypogaeae 8 parts, Herba Duchesneae Indicae 7 parts, Herba Taraxaci 10 parts.
The preparation method of glossy ganoderma composition, includes the following:
(1) take black ant, the Radix Astragali, grass summer in winter grass, Ganoderma, Rhizoma Polygonati, Radix Persicae, Testa arachidis hypogaeae, Herba Duchesneae Indicae, Herba Taraxaci mixing, add its gross weight Measuring the soak by water 30min of 8 times, filter to get filtrate and filtering residue, the water that filtering residue adds its weight 6 times decocts 30min again, filters and obtains Filtrate, merges twice filtrate, stand-by；
(2) filtrate is concentrated into the 1/3-1/2 of cumulative volume, by filtrate in 121 DEG C, steam sterilization under 0.11Mpa at 70-80 DEG C 30min, subpackage.
Black ant, have antiinflammatory, analgesia, rheumatism, removing toxic substances, calmness, relieving asthma, the pharmacological action such as hepatoprotective, to the deficiency of YIN, yang deficiency, Blood deficiency and QI and blood are double the most applicable.
The Radix Astragali Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.
Cordyceps energy invigorating the lung and the kidney, preventing phlegm from forming and stopping coughing.Cordyceps mainly contains Cordycepin, Cordyceps Cordyceps The compositions such as acid, adenosine and polysaccharide；Cordycepin can suppress the growth of the pathogenic bacteria such as streptococcus, Actinobacillus mallei anthrax bacillus, is again Anticancer active substance, the regulation effect that hormonal system and the nervous system of human body have been had；It is micro-that cordycepic acid can change human body Circulation, has obvious blood fat reducing and Antitussive and Expectorant Effect；Cordyceps polysaccharide is immunomodulator, can enhancing body to virus and post Infested resistance.
Rhizoma Polygonati preventing phlegm from forming and stopping coughing, tonifying YANG is strengthened waist, bright, is improved immunity, beauty care, anti-ageing radioprotective.
Herba Duchesneae Indicae is put down, and bitter in the mouth is micro-pungent, removing pathogenic heat from blood and toxic substance from the body, and it, to eat tender tip tender leaf, can be stir-fried and eaten, make soup or make chaffy dish Material, quality is sharp and clear, the taste of similar Caulis et Folium Chrysanthemi segeti, has the effect such as heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, it is also possible to control urinary system infection, Pharyngolaryngitis, skin infection etc..
Testa arachidis hypogaeae has hemostasis, detumescence effect.For hemophilia, hemophilioid disease, constitutional and Secondary cases thrombocytopenia Property purpura, hepatopathy hemorrhage, postoperative hemorrhage, cancerous protuberance is hemorrhage, and stomach, intestinal, lung, uterus etc. are hemorrhage.
Herba Taraxaci plant becomes containing multiple health-nutritions such as taraxol, taraxacin, choline, organic acid, inulin Point.Nature and flavor are sweet, micro-hardship, cold.Return liver, stomach warp.There are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Control pyretic toxicity, carbuncle, skin infection, interior Carbuncle, conjunctival congestion and swelling pain, damp and hot, the puckery pain of jaundice, dribbling urination, furuncle swelling toxin, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, intestinal Carbuncle, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, Acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection etc..Herba Taraxaci is raw-eaten, stir-fry and eat, cook soup, It it is the plant of dietotherapeutic.Radix Persicae is rosaceous plant Fructus Persicae or the root of Prunus davidiana or root bark, treatment jaundice, haematemesis, epistaxis, amenorrhea, The symptom such as carbuncle, hemorrhoid.
It is an advantage of the current invention that: pharmaceutical composition of the present invention by black ant, the Radix Astragali, grass summer in winter grass, Ganoderma, Rhizoma Polygonati, Radix Persicae, Testa arachidis hypogaeae, Herba Duchesneae Indicae, Herba Taraxaci form, all medicines are harmonious, blood stasis dispelling of gathering altogether dispel turbid, expelling wind and removing dampness, numbness relieving and pain relieving and and improve immunity The merit of power, has and well treats gout, gouty arthritis effect.The consumption of pharmaceutical composition of the present invention is also through invention People gropes to sum up, repeatedly study and verify preferred and obtain in a large number, shows through modern pharmacological research: the present invention has antiinflammatory, analgesia is made With；Show through clinical trial: the present invention has significant curative effect to gout, gouty arthritis, can substantially reduce Level of Serum Uric Acid, and use The untoward reaction such as gastrointestinal tract, allergy does not occurs during medicine.
Detailed description of the invention
Embodiment 1
A kind of glossy ganoderma composition with treatment gout effect, is composed of the following raw materials by weight: black ant 20 parts, the Radix Astragali 15 parts, Grass summer in winter grass 10 parts, Ganoderma 30 parts, Rhizoma Polygonati 15 parts, Radix Persicae 8 parts, Testa arachidis hypogaeae 8 parts, Herba Duchesneae Indicae 7 parts, Herba Taraxaci 10 parts.
The preparation method of glossy ganoderma composition, includes the following:
(1) take black ant, the Radix Astragali, grass summer in winter grass, Ganoderma, Rhizoma Polygonati, Radix Persicae, Testa arachidis hypogaeae, Herba Duchesneae Indicae, Herba Taraxaci mixing, add its gross weight Measuring the soak by water 30min of 8 times, filter to get filtrate and filtering residue, the water that filtering residue adds its weight 6 times decocts 30min again, filters and obtains Filtrate, merges twice filtrate, stand-by；
(2) filtrate is concentrated into the 1/2 of cumulative volume at 75 DEG C, by filtrate in 121 DEG C, steam sterilization 30min under 0.11Mpa, point Dress.
Embodiment 2
A kind of glossy ganoderma composition with treatment gout effect, is composed of the following raw materials by weight: black ant 15 parts, the Radix Astragali 10 parts, Grass summer in winter grass 5 parts, Ganoderma 25 parts, Rhizoma Polygonati 10 parts, Radix Persicae 5 parts, Testa arachidis hypogaeae 5 parts, Herba Duchesneae Indicae 5 parts, Herba Taraxaci 7 parts.
The preparation method of glossy ganoderma composition, includes the following:
(1) take black ant, the Radix Astragali, grass summer in winter grass, Ganoderma, Rhizoma Polygonati, Radix Persicae, Testa arachidis hypogaeae, Herba Duchesneae Indicae, Herba Taraxaci mixing, add its gross weight Measuring the soak by water 30min of 8 times, filter to get filtrate and filtering residue, the water that filtering residue adds its weight 6 times decocts 30min again, filters and obtains Filtrate, merges twice filtrate, stand-by；
(2) filtrate is concentrated into the 1/3 of cumulative volume at 70 DEG C, by filtrate in 121 DEG C, steam sterilization 30min under 0.11Mpa, point Dress.
Embodiment 3
A kind of glossy ganoderma composition with treatment gout effect, is composed of the following raw materials by weight: black ant 25 parts, the Radix Astragali 20 parts, Grass summer in winter grass 15 parts, Ganoderma 35 parts, Rhizoma Polygonati 20 parts, Radix Persicae 10 parts, Testa arachidis hypogaeae 12 parts, Herba Duchesneae Indicae 10 parts, Herba Taraxaci 12 parts.
The preparation method of glossy ganoderma composition, includes the following:
(1) take black ant, the Radix Astragali, grass summer in winter grass, Ganoderma, Rhizoma Polygonati, Radix Persicae, Testa arachidis hypogaeae, Herba Duchesneae Indicae, Herba Taraxaci mixing, add its gross weight Measuring the soak by water 30min of 8 times, filter to get filtrate and filtering residue, the water that filtering residue adds its weight 6 times decocts 30min again, filters and obtains Filtrate, merges twice filtrate, stand-by；
(2) filtrate is concentrated into the 1/2 of cumulative volume at 80 DEG C, by filtrate in 121 DEG C, steam sterilization 30min under 0.11Mpa, point Dress.
In order to confirm the efficacy and saferry of medicine of the present invention, also Ganoderma pharmaceutical composition is carried out pharmacodynamics test and examined Examine.The research method and the result of the test that are used are as follows:
Take Kunming mouse 60, male and female half and half, body weight 18-22g, be randomly divided into normal saline group, endo-medicine of the present invention Dosage group (8g raw medicinal herbs/kg), medicine high dose group of the present invention in low dose group (4g raw medicinal herbs/kg), medicine of the present invention (16g raw medicinal herbs/kg), positive controls (0.1mg/kg), gavage normal saline, medicine of the present invention and colchicine, often respectively Day 1 time, continuous 4d.After last is administered 1h, in addition to normal saline group, remaining each treated animal Intraperitoneal injection of hypoxanthine 1mg/kg is made Become mice hyperuricemia, the capacity blank liquid such as normal saline group injection.0.5h after injection, each treated animal plucks eyeball and takes blood, 3000r/min is centrifuged 15min, takes serum and surveys Level of Serum Uric Acid.
As seen from the table, senior middle school of the present invention low dose group all can reduce Mouse Blood uric acid level, compare with model group have aobvious Write sex differernce.
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with Modify, all should belong to the covering scope of the present invention.

Claims (3)

1. a glossy ganoderma composition with treatment gout effect, it is characterised in that: it is composed of the following raw materials by weight: black ant 15-25 part, Radix Astragali 10-20 part, winter grass summer grass 5-15 part, Ganoderma 25-35 part, Rhizoma Polygonati 10-20 part, Radix Persicae 5-10 part, Testa arachidis hypogaeae 5-12 part, Herba Duchesneae Indicae 5-10 part, Herba Taraxaci 7-12 part.
A kind of glossy ganoderma composition with treatment gout effect the most according to claim 1, it is characterised in that: by following heavy Amount part raw material composition: black ant 20 parts, the Radix Astragali 15 parts, grass summer in winter grass 10 parts, Ganoderma 30 parts, Rhizoma Polygonati 15 parts, Radix Persicae 8 parts, Testa arachidis hypogaeae 8 Part, Herba Duchesneae Indicae 7 parts, Herba Taraxaci 10 parts.
The preparation method of a kind of glossy ganoderma composition with treatment gout effect the most according to claim 1, its feature exists In: described method includes the following:
(1) take black ant, the Radix Astragali, grass summer in winter grass, Ganoderma, Rhizoma Polygonati, Radix Persicae, Testa arachidis hypogaeae, Herba Duchesneae Indicae, Herba Taraxaci mixing, add its gross weight Measuring the soak by water 30min of 8 times, filter to get filtrate and filtering residue, the water that filtering residue adds its weight 6 times decocts 30min again, filters and obtains Filtrate, merges twice filtrate, stand-by；
(2) filtrate is concentrated into the 1/3-1/2 of cumulative volume, by filtrate in 121 DEG C, steam sterilization under 0.11Mpa at 70-80 DEG C 30min, subpackage.
CN201610633544.0A 2016-08-05 2016-08-05 A kind of glossy ganoderma composition with treatment gout effect Pending CN106138709A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102940695A (en) * 2012-11-01 2013-02-27 成都医路康医学技术服务有限公司 Medicine composition for treating gout
CN104069162A (en) * 2014-07-09 2014-10-01 青岛澳普瑞资讯科技有限公司 Traditional Chinese medicine for treating gouty arthritis and various bone and arthrosis pains
CN104491172A (en) * 2014-11-28 2015-04-08 河南省新境界酒业有限公司 Health wine with effect of treating gout

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102940695A (en) * 2012-11-01 2013-02-27 成都医路康医学技术服务有限公司 Medicine composition for treating gout
CN104069162A (en) * 2014-07-09 2014-10-01 青岛澳普瑞资讯科技有限公司 Traditional Chinese medicine for treating gouty arthritis and various bone and arthrosis pains
CN104491172A (en) * 2014-11-28 2015-04-08 河南省新境界酒业有限公司 Health wine with effect of treating gout

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
徐蕾: "《痛风中医特色疗法》", 30 June 2012, 人民军医出版社 *
徐西中: "痛风病机与治则探讨", 《河南中医学院学报》 *

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