CN101897771B - Medicine composition for preventing or treating neurasthenia - Google Patents
Medicine composition for preventing or treating neurasthenia Download PDFInfo
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- CN101897771B CN101897771B CN2009100848753A CN200910084875A CN101897771B CN 101897771 B CN101897771 B CN 101897771B CN 2009100848753 A CN2009100848753 A CN 2009100848753A CN 200910084875 A CN200910084875 A CN 200910084875A CN 101897771 B CN101897771 B CN 101897771B
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- cortex cinnamomi
- rhizoma
- rhizoma nardostachyos
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Abstract
The invention relates to a medicine composition for preventing or treating neurasthenia, in particular to an oral preparation prepared from the following raw materials in parts by weight: 40-100 parts of Chinese medicinal herb Pistacia chinensis Bunge, 1-40 parts of cortex cinnamomi and 20-80 parts of rhizoma nardostachyos. The invention also discloses a health food or medicine thereof capable of being used for preventing or treating vexation, insomnia, dreaminess, palpitation and other neurasthenia.
Description
Technical field
The present invention relates to medical technical field, specifically, relate to a kind of neurasthenic pharmaceutical composition that prevents or treat.
Background technology
Pharmaceutical composition involved in the present invention is " handed over safe ball " and add flavor and got by the Chinese medicine recipe.Hand over safe ball one side, come from diligent " the Han Shi doctor the is logical " book of Ming Dynasty Korea Spro, name is seen Qing Dynasty's " four sections letter efficacious prescriptions ", and we are comprised of Rhizoma Coptidis, Cortex Cinnamomi two flavor medicines.Though flavour of a drug are simple, compatibility is unique, and medicine cold and heat mutually 5 embody the method for clear Wen Bingyong, and take clearly as main, the function relieving restlessness that clears away heart-fire, and guiding fire to origin, restoring normal coordination between the heart and kidney has significant curative effect to the insomnia of disarmony between the heart and kidney.Because of its prescription novel, evident in efficacy, for extensively praising highly later age, clinically except the diseases such as Cure for insomnia, cardiopalmus, seminal emission, the multiple chronic inflammatory diseases such as the various arrhythmia of the treatment of also using, gastritis and chronic pharyngitis, tonsillitis, recurrent stomatitis.Hand over the initiative of safe ball, opened up the new approaches of Cure for insomnia.The traditional Chinese medical science is dialectical to insomnia, thinks due to lack of preservation of spirit or irritability more.Select that the medicine prescription is many calms the nerves or tranquillization with heavy prescription is started with from self-restraint.The product of handing over safe ball Fang Zhongwu to calm the nerves simply, from classification of TCD, Rhizoma Coptidis is antipyretic, Cortex Cinnamomi is drugs for dispelling internal cold, but two medicine compatibilities really can be controlled insomnia.
Radix Et Rhizoma Nardostachyos is the dry root and rhizome of Valerianaceae plant Radix Et Rhizoma Nardostachyos Nardostachys chinensis Batal. or spoon Ye Gansong Nardostachys jatamansi DC..。Radix Et Rhizoma Nardostachyos as Chinese medicine record in " in the Chinese Pharmacopoeia 2005 version, clinical gastropathy, cardiopalmus, gallstones and kidney stones, breast abdomen feeling of fullness, cough, asthma, beriberi, the melancholia etc. of being used for the treatment of, determined curative effect, thus cause the Chinese scholars extensive concern.Modern pharmacological research shows that Radix Et Rhizoma Nardostachyos has calmness, spasmolytic, blood pressure lowering, arrhythmia, the effect such as antibacterial, and main component is volatile oil, ter penoids.Document (Zhang Wenheng, Chen Hubiao, Chinese Wild plant resources, 18 (3): 11-14) show to Rhizoma et radix valerianae, similar sedation is arranged with Rana nigromaculata, rabbit and the white mice evidence Radix Et Rhizoma Nardostachyos of making comparisons.The volatile material of spoon Ye Gansong also has similar sedation, and has certain stable effect; Its organic solvent extract to mice, rat, cat is oral or lumbar injection, can cause calmness, boost, and is the highest with ethanol extraction effect.Effective ingredient valerone in Radix Et Rhizoma Nardostachyos has the effect of anti-arrhythmia.Inhibition to atopy sinus rhythm (the not anesthetized dog after coronary artery second phase ligation) is better than quinidine and Radix et Rhizoma Nardostachyos volatile oil; And the inhibition aspect damaging atrial flutter and the atrial fibrillation of Aconitum carmichjaelii Debx. alkalescence is identical with quinidine.Radix Et Rhizoma Nardostachyos ethanol proposes liquid has the antagonism barium chloride to bring out rat ventricular and chloroform-epinephrine brings out the ARR effect of rabbit, and the refractory stage that can extend the rabbit isolated atria, analyzes its antiarrhythmic effect and may be the direct repression to cardiac muscle.With the experiment of rabbit nerve ischemic-type arrhythmia animal model, after intravenous injection Radix Et Rhizoma Nardostachyos water extract-alcohol precipitation liquid, ventricular premature contraction significantly reduces.
The present invention is take Chinese crude drug Rhizoma Coptidis, Cortex Cinnamomi, Radix Et Rhizoma Nardostachyos as raw material, the effective ingredient by extracting above-mentioned medical material or directly be ground into fine powder and make prevention or treat neurasthenic pharmaceutical composition.Curative effect aspect the neurasthenias such as pharmaceutical composition involved in the present invention is vexed in treatment, insomnia, dreaminess, cardiopalmus is better than handing over safe ball.
Summary of the invention
The invention provides a kind of neurasthenic pharmaceutical composition that prevents or treat, it is characterized in that by Chinese Drug Rhizomes of Coptis, Cortex Cinnamomi, Radix Et Rhizoma Nardostachyos be the preparation that raw material is made.The weight proportion of three kinds of medicinal raw materials of said composition is: Rhizoma Coptidis 40-100 part, and Cortex Cinnamomi 1-40 part, Radix Et Rhizoma Nardostachyos 20-80 part, the preferred weight proportioning is Rhizoma Coptidis 60-90 part, Cortex Cinnamomi 3-20 part, Radix Et Rhizoma Nardostachyos 30-60 part.Above-mentioned composition can be prepared into pharmaceutically acceptable oral formulations with pharmaceutically acceptable adjuvant or adjuvant sexual element, as tablet, hard capsule, soft capsule, drop pill, granule or oral liquid.
Pharmaceutical composition of the present invention can be used for preparing prevention or treats health food or the medicine of the neurasthenias such as vexed, insomnia, dreaminess, cardiopalmus.
The present invention is take Rhizoma Coptidis, Cortex Cinnamomi, Radix Et Rhizoma Nardostachyos three flavor Chinese medicines as raw material, and prescription is simple, but evident in efficacy.The Rhizoma Coptidis nature and flavor are bitter, cold, and GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel have heat clearing and damp drying, and the eliminating fire and detoxication effect can be used for treating unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia.The Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet has benefit fiery supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the promoting blood circulation to restore menstrual flow effect is mainly used in treating sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.The Radix Et Rhizoma Nardostachyos nature and flavor are hot, sweet, and temperature is returned spleen, stomach warp, has regulating QI to relieve pain, and the relieving stagnation and activating the spleen effect is mainly used in treating distension and fullness in the abdomen, inappetence, vomiting.Above-mentioned three flavor Chinese medicines are combined into a side, cold and heat phase 5, clear Wen Bingyong, the relieving restlessness that clears away heart-fire, guiding fire to origin, restoring normal coordination between the heart and kidney.Can produce synergism, evident in efficacy aspect the treatment psychasthenia.
The specific embodiment of form, be described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1
The inhibitory action research of pharmaceutical composition of the present invention to spontaneous activity in mice.
Get 40 of white mice, body weight 22 ± 2g, male and female half and half are divided into 3 groups.
Matched group: gavage normal saline.
Treatment I group: gavage Rhizoma Coptidis and the Cortex Cinnamomi weight ratio decocting liquid of 10: 1.
Treatment II group: gavage Rhizoma Coptidis, Cortex Cinnamomi and the Radix Et Rhizoma Nardostachyos weight ratio decocting liquid of 10: 1: 5.
Decocting liquid concentration is for containing crude drug amount 1g/ml, gavage amount 0.2ml/10g, normal saline isometric(al) gavage is observed respectively before and after medication walk about time and two forelimbs of 1 hour mice and is upwards praised number of times, observing time 2min.Experimental result sees Table 1.
The inhibitory action of table 1 pair spontaneous activity in mice
As can be seen from Table 1, treatment group all has inhibitory action to the spontaneous activity of mice, and treatment II group is more remarkable to the sedation of mice.
Embodiment 2
The impact of pharmaceutical composition p-chlorophcnylalaninc induced insomnia rat blood serum cytokine of the present invention.
Get 40 of SD rats, body weight 200g ± 20g, male and female half and half are divided into normal group, model group, treatment I group, treatment II group, 10 every group.
Treatment I group: Rhizoma Coptidis and the Cortex Cinnamomi weight ratio decocting liquid of 5: 1.
Treatment II group: Rhizoma Coptidis, Cortex Cinnamomi and the Radix Et Rhizoma Nardostachyos weight ratio decocting liquid of 5: 1: 3.
Except normal group, other each group is disposable lumbar injection PCPA 300mg/kg all, observes rat behavior after 30h, copies the rat model of having a sleepless night fully.After modeling success, treatment group is gavage decocting liquid respectively, and dosage is for by crude drug 2.5g/kg, and Normal group and model group are used respectively the normal saline gavage, and consumption is and administration group isometric(al), every day 1 time, continuous 7d.After last administration 24h was respectively organized in experiment, after 100g/L chloral hydrate lumbar injection (2.3mL/kg) anesthesia, abdominal vein was got blood 3mL, standing 1h, 4 ℃ are spent the night, the centrifugal 10min of 10000r/min, get supernatant, adopt the ELISA method to detect IL-1 and TNF-α in rat blood serum.
Rat wakefulness state occurs after PCPA lumbar injection 30h, the treatment group successive administration is after 7 days, and the rat insomnia obviously alleviates, and each organizes IL-1 and TNF-α testing result sees Table 2.
Rat blood serum IL-1 respectively organized by table 2 and the TNF-alpha content compares (pg/ml of unit)
| Group | N | IL-1 | TNF-α |
| Normal group | 10 | 72.468±18.136 | 58.167±21.471 |
| Model group | 10 | 33.711±16.254 | 28.964±18.611 |
| Treatment I group | 10 | 57.421±20.866 | 41.578±22.627 |
| Treatment II group | 10 | 67.193±17.348 | 53.156±17.223 |
Display model group IL-1 and TNF-alpha levels significantly reduce as a result, and treatment group IL-1 and TNF-alpha levels all are significantly increased, and treatment II group effect is more obvious.
Embodiment 3
The preparation of medicine of the present invention:
Take the raw material of weight proportion: Rhizoma Coptidis 400g, Cortex Cinnamomi 10g, Radix Et Rhizoma Nardostachyos 300g decocts with water, and is concentrated, adds sucrose, granulates, and granulate is prepared into granule.
Embodiment 4
The preparation of medicine of the present invention:
Take the raw material of weight proportion: Rhizoma Coptidis 600g, Cortex Cinnamomi 200g, Radix Et Rhizoma Nardostachyos 200g.Wherein Rhizoma Coptidis and Cortex Cinnamomi decoct with water, and Radix Et Rhizoma Nardostachyos adds 50% ethanol and decocts, and be concentrated respectively, merges concentrated solution, adds starch, granulates, and granulate adds magnesium stearate, tabletting, and get final product.
Embodiment 5
The preparation of medicine of the present invention:
Take the raw material of weight proportion: Rhizoma Coptidis 1000g, Cortex Cinnamomi 100g, Radix Et Rhizoma Nardostachyos 500g, wherein Rhizoma Coptidis and Radix Et Rhizoma Nardostachyos decoct with water, and are condensed into thick paste.Cortex Cinnamomi powder is broken into fine powder, adds mixing in above-mentioned thick paste, granulate, and granulate, encapsulated, and get final product.
Embodiment 6
The preparation of medicine of the present invention:
Take the raw material of weight proportion: Rhizoma Coptidis 800g, Cortex Cinnamomi 400g, Radix Et Rhizoma Nardostachyos 600g.Wherein Radix Et Rhizoma Nardostachyos extraction by steam distillation volatile oil, standby.Medicinal residues and Rhizoma Coptidis, Cortex Cinnamomi decoct with water, and concentrated, drying gets dry extract, adds Radix et Rhizoma Nardostachyos volatile oil, and soybean oil, Cera Flava, span 20 are crossed colloid mill and ground, the compacting soft capsule, and get final product.
Embodiment 7
The preparation of medicine of the present invention:
Take the raw material of weight proportion: Rhizoma Coptidis 1000g, Cortex Cinnamomi 200g, Radix Et Rhizoma Nardostachyos 800g decocts with water, and is concentrated, adds sucrose, and antiseptic is prepared into oral liquid, and get final product.
Embodiment 8
The preparation of medicine of the present invention:
Take the raw material of weight proportion: Rhizoma Coptidis 400g, Cortex Cinnamomi 400g, Radix Et Rhizoma Nardostachyos 400g decocts with water, and concentrated, drying gets extract.The said extracted thing is added in the Macrogol 4000 of molten condition, mixing is poured in pill dripping machine, makes drop pill, and get final product.
Claims (3)
1. one kind is prevented or treats neurasthenic pharmaceutical composition, and it is characterized in that: it is to be Rhizoma Coptidis 40-100 part by weight ratio, Cortex Cinnamomi 1-40 part, the preparation that Radix Et Rhizoma Nardostachyos 20-80 part is made.
2. prevention according to claim 1 or treat neurasthenic pharmaceutical composition is characterized in that the weight proportion of described three kinds of raw material of Chinese medicine is: Rhizoma Coptidis 60-90 part, Cortex Cinnamomi 3-20 part, Radix Et Rhizoma Nardostachyos 30-60 part.
3. prevention according to claim 1 and 2 or treat neurasthenic pharmaceutical composition, it is characterized in that, it is to be raw material by Chinese Drug Rhizomes of Coptis, Cortex Cinnamomi, Radix Et Rhizoma Nardostachyos, extract active ingredient or steam distillation extracts active ingredient or directly pulverizes as fine powder is used as medicine through decocting method, add pharmaceutically acceptable adjuvant or the adjuvant sexual element is prepared into pharmaceutically acceptable tablet, hard capsule, soft capsule, drop pill, granule or oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100848753A CN101897771B (en) | 2009-05-26 | 2009-05-26 | Medicine composition for preventing or treating neurasthenia |
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| CN2009100848753A CN101897771B (en) | 2009-05-26 | 2009-05-26 | Medicine composition for preventing or treating neurasthenia |
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| CN101897771A CN101897771A (en) | 2010-12-01 |
| CN101897771B true CN101897771B (en) | 2013-06-12 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102772647A (en) * | 2012-07-13 | 2012-11-14 | 李承平 | Group of tablets for restoring normal coordination between heart and kidney |
| CN103385897A (en) * | 2013-06-20 | 2013-11-13 | 王保安 | Chinese medicine for treating palpitation, neurasthenia and stomach diseases and preparation method and applications thereof |
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2009
- 2009-05-26 CN CN2009100848753A patent/CN101897771B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 交泰丸治疗失眠证的文献与实验研究;林杏娥;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20061015(第10期);中文摘要 * |
| 林杏娥.交泰丸治疗失眠证的文献与实验研究.《中国优秀硕士学位论文全文数据库 医药卫生科技辑》.2006,(第10期),中文摘要. |
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Application publication date: 20101201 Assignee: Guangdong star Pharmaceutical Co., Ltd. Assignor: Beijing Xinghao Medical Co., Ltd. Contract record no.: 2015440000066 Denomination of invention: Medicine composition for preventing or treating neurasthenia Granted publication date: 20130612 License type: Exclusive License Record date: 20150325 |
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