CN1660281A - Combination of medication for treating gastric disease and preparing method - Google Patents
Combination of medication for treating gastric disease and preparing method Download PDFInfo
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- CN1660281A CN1660281A CN 200410089345 CN200410089345A CN1660281A CN 1660281 A CN1660281 A CN 1660281A CN 200410089345 CN200410089345 CN 200410089345 CN 200410089345 A CN200410089345 A CN 200410089345A CN 1660281 A CN1660281 A CN 1660281A
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Abstract
A Chinese medicine in the form of particles for treating gastrosis is prepared from 5 Chinese-medicinal materials including cloves, coptis root, amomum fruit, dandelion herb, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to Chinese patent medicine, specifically a kind of is the pharmaceutical composition and preparation method thereof of the treatment gastropathy of main component with Chinese medicine.
Background technology
Now, the trend that patients with gastric disease increases day by day is very remarkable, mainly due to diet can not control, sudden and violent wine gluttony or work unordered, fatigue and diet do not have due to numerous factors such as rule or long-term nutrition imbalance.Though the stomach medicine is now numerous,, SANJIU WEITAI peaceful etc. as the existing WENWEISHU of Chinese medicine, YANGWEISHU, Veytalo; Western medicine has bismuth aluminate compound, SIDASHU, losec, ranitidine hydrochloride, gastropine etc., but its therapeutic effect is not very good.These medicines can only relief of symptoms, takes stopgap measures and can not effect a permanent cure, and just can not thoroughly effect a radical cure gastropathy.In fact, this does not reach treatment truly yet.And the kind of gastropathy is more, and the price of stomach medicine is higher, and the patient of some low incomes is truly had white elephant.How to seek and the invention good effect, short treating period, the honest and clean stomach medicine of price is a great problem.Particularly people's stomach is the biorgan of a special shape, and is rough and uneven in surface, on gastric antrum is arranged, have at the bottom of the stomach down, in gastral cavilty is arranged, general stomach medicine all is difficult to reach good therapeutic effect to the focus of privileged sites such as gastric antrum, stomach pylorus, duodenum.The medicine time that has is long, and medicine has been produced dependency, outbreak repeatedly, and delay treating time, even cause other disease.
Summary of the invention
Purpose of the present invention is exactly in order to address the above problem, and providing a kind of is the pharmaceutical composition and preparation method thereof of the treatment gastropathy of main component with Chinese medicine.The dosage form of its prescription and selection has very strong specific aim to treatment gastropathy, and has the medicining cycle weak point, and is evident in efficacy, and the cure rate height is difficult for characteristics such as recurrence and cost are low, and very strong generalization is arranged.
Purpose of the present invention can take following method to realize:
A kind of pharmaceutical composition for the treatment of gastropathy is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials:
Flos Caryophylli 50-500 weight portion, Rhizoma Coptidis 25-250 weight portion, Rhizoma Atractylodis Macrocephalae 50-500 weight portion, Fructus Amomi 25-250 weight portion, Herba Taraxaci 30-200 weight portion.
Described preparation of drug combination method is characterized in that comprising the steps:
Take by weighing Flos Caryophylli by prescription, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Herba Taraxaci;
Flos Caryophylli wherein, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi and Herba Taraxaci extract volatile oil, and volatile oil is deposited in addition;
Medicinal residues and Rhizoma Coptidis are used the alcohol reflux secondary, and each 2 hours, leave standstill, filter, behind the filtrate recycling ethanol, simmer down to extractum;
With extractum, volatile oil and an amount of tartaric acid, citric acid, sodium bicarbonate mixing, constantly stir, treat medicine moistening, softening, agglomerating back taking-up, make appropriate particles, dry under 50-60 ℃ of temperature, the sealed container of packing into is immediately preserved standby.
Purpose of the present invention can also take following method to realize:
Its formula optimization is:
Flos Caryophylli 100 weight portions, Rhizoma Coptidis 150 weight portions, the Rhizoma Atractylodis Macrocephalae 200 weight portions, Fructus Amomi 100 weight portions, Herba Taraxaci 150 weight portions.
Described pharmaceutically acceptable additives are following one or more: ethylparaben, tartaric acid, citric acid, sodium bicarbonate, lecithin, sodium lauryl sulphate, glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, dried starch.
Its dosage form can be a said dosage form on any pharmaceutics, as effervescent granule electuary, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; Preferred effervescent granule electuary.
The present invention is an effective ingredient with Flos Caryophylli, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Herba Taraxaci, the compound preparation energy heat-clearing and toxic substances removing of making, spleen benefiting and stimulating the appetite; Can kill or suppress stomach Helicobacter pylori.Its medicine time is short, no dependence, and curative effect is obvious, the cure rate height, treatment gastropathy is with strong points, and sphere of action is extensive.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1:
The preparation method of effervescent granule electuary of the present invention:
Get Flos Caryophylli 100 grams, Rhizoma Coptidis 150 grams, the Rhizoma Atractylodis Macrocephalae 200 grams, Fructus Amomi 100 grams, Herba Taraxaci 150 grams.Flos Caryophylli wherein, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi and Herba Taraxaci extract volatile oil with the way of distillation or volatile oil extractor earlier, and volatile oil is deposited in addition.Medicinal residues and Rhizoma Coptidis be with 75% alcohol reflux secondary, and each 2 hours, leave standstill, filter, behind the filtrate recycling ethanol, press 1: 1 the extractum of weight simmer down to of medical material.Then, with extractum, volatile oil and an amount of tartaric acid, citric acid, sodium bicarbonate mixing, constantly stir, treat medicine moistening, softening, agglomerating back taking-up, make appropriate particles, dry under 50-60 ℃ of temperature, the sealed container of packing into is immediately preserved standby.
In like manner, the present invention said medicine and suitable medicinal additive combination, production technology also can be made into the capsule or the tablet of treatment gastropathy routinely.
Application examples 1:
Matched group is Flos Caryophylli, each 100 weight portion of Rhizoma Coptidis, and of the present invention group is the effervescent granule electuary of embodiment 1.With 30 days be a course of treatment, to total 218 routine patient treatments the results are shown in Table 1, table 2.
Table 1
Group patient's number is cured number cure rate (%)
Matched group 80 13 16.2
Of the present invention group 138 120 86.9.
Table 2
Group is cured not healing number of number and is added up to
Matched group 13 (48.81) 67 (31.19) 80
Of the present invention group 120 (84.19) 18 (53.81) 138
Add up to 133 85 218
Look into subordinate list X
2Value show X
2 0.05(1)=3.841 X
2 0.01(1)=6.635
This example is calculated X
2 0.01=9.24＞6.635 P＜of the present invention group of therapeutic effect of 0.01 explanation has highly significant.By inquiry, wherein 18 routine effects do not show, its main cause be the patient during medication, took other medicines or heavy drinking or work simultaneously and overworked etc. due to the various factors.Then, the continuation medication is kept a course of treatment and is prohibited against alcoholic drinks or take a good rest, and finds that the gastropathy symptom is improved in a large number, and has obtained satisfied effect.
Claims (5)
1, a kind of pharmaceutical composition for the treatment of gastropathy is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials:
Flos Caryophylli 50-500 weight portion, Rhizoma Coptidis 25-250 weight portion, Rhizoma Atractylodis Macrocephalae 50-500 weight portion, Fructus Amomi 25-250 weight portion, Herba Taraxaci 30-200 weight portion.
2, pharmaceutical composition according to claim 1 is characterized in that formula optimization is:
Flos Caryophylli 100 weight portions, Rhizoma Coptidis 150 weight portions, the Rhizoma Atractylodis Macrocephalae 200 weight portions, Fructus Amomi 100 weight portions, Herba Taraxaci 150 weight portions.
3, pharmaceutical composition according to claim 1 is characterized in that: described pharmaceutically acceptable additives are following one or more: ethylparaben, tartaric acid, citric acid, sodium bicarbonate, lecithin, sodium lauryl sulphate, glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, dried starch.
4, preparation of drug combination method as claimed in claim 1 is characterized in that comprising the steps:
Take by weighing Flos Caryophylli by prescription, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Herba Taraxaci;
Flos Caryophylli wherein, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi and Herba Taraxaci extract volatile oil, and volatile oil is deposited in addition;
Medicinal residues and Rhizoma Coptidis are used the alcohol reflux secondary, and each 2 hours, leave standstill, filter, behind the filtrate recycling ethanol, simmer down to extractum;
With extractum, volatile oil and an amount of tartaric acid, citric acid, sodium bicarbonate mixing, constantly stir, treat medicine moistening, softening, agglomerating back taking-up, make appropriate particles, dry under 50-60 ℃ of temperature, the sealed container of packing into is immediately preserved standby.
5, pharmaceutical composition according to claim 1 is characterized in that: its dosage form can be a said dosage form on any pharmaceutics, as effervescent granule electuary, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; Preferred effervescent granule electuary.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100893455A CN100509042C (en) | 2004-12-09 | 2004-12-09 | Combination of medication for treating gastric disease and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100893455A CN100509042C (en) | 2004-12-09 | 2004-12-09 | Combination of medication for treating gastric disease and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1660281A true CN1660281A (en) | 2005-08-31 |
| CN100509042C CN100509042C (en) | 2009-07-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100893455A Expired - Fee Related CN100509042C (en) | 2004-12-09 | 2004-12-09 | Combination of medication for treating gastric disease and preparing method thereof |
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| CN (1) | CN100509042C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070923A (en) * | 2013-01-23 | 2013-05-01 | 广州铁路职业技术学院 | Medicated wine for treating stomach disease and preparation method thereof |
| CN108355103A (en) * | 2018-05-15 | 2018-08-03 | 济南市中医医院 | Treat the Chinese medicine composition of Hp-relative Gastritis and peptic ulcer |
| CN115282246A (en) * | 2022-08-11 | 2022-11-04 | 福建中益制药有限公司 | Traditional Chinese medicine composition for inhibiting helicobacter pylori and preparation method thereof |
-
2004
- 2004-12-09 CN CNB2004100893455A patent/CN100509042C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070923A (en) * | 2013-01-23 | 2013-05-01 | 广州铁路职业技术学院 | Medicated wine for treating stomach disease and preparation method thereof |
| CN103070923B (en) * | 2013-01-23 | 2014-07-16 | 广州铁路职业技术学院 | Medicated wine for treating stomach disease and preparation method thereof |
| CN108355103A (en) * | 2018-05-15 | 2018-08-03 | 济南市中医医院 | Treat the Chinese medicine composition of Hp-relative Gastritis and peptic ulcer |
| CN108355103B (en) * | 2018-05-15 | 2020-12-04 | 济南市中医医院 | Traditional Chinese medicine composition for treating helicobacter pylori related gastritis and peptic ulcer |
| CN115282246A (en) * | 2022-08-11 | 2022-11-04 | 福建中益制药有限公司 | Traditional Chinese medicine composition for inhibiting helicobacter pylori and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100509042C (en) | 2009-07-08 |
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Granted publication date: 20090708 Termination date: 20111209 |