CN100515484C - Iprazole containing medicine - Google Patents
Iprazole containing medicine Download PDFInfo
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- CN100515484C CN100515484C CNB200710105984XA CN200710105984A CN100515484C CN 100515484 C CN100515484 C CN 100515484C CN B200710105984X A CNB200710105984X A CN B200710105984XA CN 200710105984 A CN200710105984 A CN 200710105984A CN 100515484 C CN100515484 C CN 100515484C
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- rhizoma
- chinese medicine
- medicine
- radix
- treatment
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Abstract
The present invention discloses one kind of synergistic medicine composition containing iprazole and Chinese medicine extract, and the application of the medicine composition in preparing medicine for treating gastric ulcer.
Description
The present invention relates to a kind of medicine for the treatment of gastropathy, is the compositions of being made by Chinese crude drug extract and Western medicine, is particularly suitable for the medicine as treatment gastritis, peptic ulcer gastropathy such as (containing gastric ulcer and duodenal bulbar ulcer).
Gastropathy, particularly gastritis (shallow harmony in the exterior atrophic), peptic ulcer (containing gastric ulcer and duodenal bulbar ulcer) is a kind of commonly encountered diseases, frequently-occurring disease.At present, the medicine for the treatment of these diseases is more, the curative effect of the degree of having nothing in common with each other, but generally speaking, curative effect is not ideal enough, and relapse rate is higher after the drug withdrawal, and with regard to better medicine at present commonly used: its effective percentage is below 80%, and its relapse rate is more than 36%.
Purpose of the present invention just is: invent a kind of composition medicine of being made up of Chinese medicine extract and Western medicine for the treatment of gastric ulcer, to improve the treatment curative effect and to reduce relapse rate.
The present invention realizes its purpose like this: the present composition comprises Chinese medicine extract and Western medicine, and wherein Chinese medicine extract is prepared by following method:
Chinese medicine medical material component and proportional quantity thereof, % counts with percentage ratio:
Rhizoma Alpiniae Officinarum 4, the Radix Aucklandiae 3, Os Sepiae 3, Rhizoma Curcumae 10 ， Cao guans 1,
Radix Et Rhizoma Nardostachyos 6, dried Alumen 3, Endothelium Corneum Gigeriae Galli 3, Rhizoma Coptidis 3, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10,
Rhizoma Corydalis 11, Fructus Hordei Germinatus 1, Radix Aristolochiae 20, Semen Trichosanthis 2, Corium elephatis 20.
The summation of its each component is 100%.
Earlier Chinese crude drug is cleaned, press the proportional quantity metering, and the medicine village is concocted with conventional concocting method, powder is defended in pulverizing, decoct with water, and filtration, concentrated filtrate is to thick paste, drying.
Pharmaceutical composition Chinese medicine and western medicine of the present invention in addition is an ilaprazole, and the weight ratio of Chinese medicine extract and Western medicine is 53: 1.
Chinese medicine extract prescription in the pharmaceutical composition of the present invention is from the embodiment 1 of CN1055015C.
Pharmaceutical composition of the present invention can be made into various peroral dosage forms, and three times on the one, each 2 grams, seriously ill person's four times a day, boiled water is taken after mixing it with water.For gastritis (shallow table or atrophic), 7 is a course of treatment, serve on 2-3 the course of treatment, and for peptic ulcer (containing gastric ulcer and bulboduodenal ulcer), be a course of treatment January, serve on 2-3 the course of treatment.Taboo: dry peppery, the raw food food such as hard of fasting.
Clinical effectiveness:
To gastric ulcer 36 examples, treat 5 courses of treatment after.Through hospital's fiber microscopy and biopsy, 17 examples of wherein fully recovering, effective 17 examples, invalid 2 examples.Average total effective rate is that the toxic side effect reaction is found at the 94.4%. end.And with the pure Chinese medicine extract or the ilaprazole of Isodose, effective percentage is respectively 66% and 84%.
The treatment standard declaration: recovery from illness refers to after 2-3 the course of treatment 1 clinical symptom disappearance.Through fiber microscopy and biopsy, foci disappearance.Effectively refer to behind 2～8 strokes, through fiber microscopy and biopsy, clinical symptom disappearance, the lesion tissue scope is dwindled.Invalid finger is after 2-3 the course of treatment, and clinical symptoms does not have significant change before fiber microscopy and biopsy and treatment.
Pharmacology and resultant effect analysis.The Rhizoma Curcumae heat-clearing and toxic substances removing of this medicine with the same usefulness of Rhizoma Coptidis, strengthens the heat reliving and toxin-eliminating effect, Corium elephatis granulation promoting good medicine, and dried Alumen is held back skin ulcer, reuses poliosis, the same usefulness of three flavors, granulation promoting power is grand, and it is remarkable to hold back skin ulcer, promotes the lesion tissue reparation effectively, and well can end digestive tract hemorrhage preferably; Semen Trichosanthis a surname spleen helps circulation of qi promoting intestinal stasis relieving class efficacy of drugs such as Radix Et Rhizoma Nardostachyos more remarkable, has effectively promoted the recovery of gastric motility function, reuses Rhizoma Corydalis, Radix Aristolochiae, fast and effeciently pain relieving.Therefore, comprehensive compatibility, this Chinese patent medicine is heat-clearing and toxic substances removing effectively, and effectively gastric acid inhibitory secretion of ilaprazole.The Chinese medicine and western medicine binding energy fundamentally reaches therapeutic purposes.
Claims (2)
1 one kinds of compositionss for the treatment of gastric ulcer, said composition comprises Chinese medicine extract and Western medicine, and wherein Chinese medicine extract is prepared by following method:
Chinese medicine medical material component and proportional quantity thereof, % counts with percentage ratio:
Rhizoma Alpiniae Officinarum 4, the Radix Aucklandiae 3, Os Sepiae 3, Rhizoma Curcumae 10, Amomum globosum loureiro 1,
Radix Et Rhizoma Nardostachyos 6, dried Alumen 3, Endothelium Corneum Gigeriae Galli 3, Rhizoma Coptidis 3, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10,
Rhizoma Corydalis 11, Fructus Hordei Germinatus 1, Radix Aristolochiae 20, Semen Trichosanthis 2, Corium elephatis 20.
The summation of its each component is 100%,
Earlier Chinese crude drug is cleaned, press the proportional quantity metering, and medical material is concocted with conventional concocting method, be ground into powder, decoct with water, filtration, concentrated filtrate is to thick paste, drying;
Pharmaceutical composition Chinese medicine and western medicine of the present invention in addition is an ilaprazole, and the weight ratio of Chinese medicine extract and Western medicine is 53: 1.
The purposes of 2 compositionss as claimed in claim 1 in the medicine of preparation treatment gastric ulcer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710105984XA CN100515484C (en) | 2007-06-05 | 2007-06-05 | Iprazole containing medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710105984XA CN100515484C (en) | 2007-06-05 | 2007-06-05 | Iprazole containing medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101066435A CN101066435A (en) | 2007-11-07 |
| CN100515484C true CN100515484C (en) | 2009-07-22 |
Family
ID=38879217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200710105984XA Expired - Fee Related CN100515484C (en) | 2007-06-05 | 2007-06-05 | Iprazole containing medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100515484C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732663B (en) * | 2009-12-30 | 2011-11-02 | 宁波市鄞州奥胜生物科技有限公司 | Rebamipide-containing Chinese and western medicinal composition |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797359B (en) * | 2009-12-30 | 2011-06-15 | 叶希友 | Chinese and western medicinal composition containing pantoprazole |
| CN101797357B (en) * | 2009-12-30 | 2011-06-15 | 李孟 | Chinese-western medicinal composition containing lansoprazole |
| CN101797358B (en) * | 2009-12-30 | 2011-06-15 | 李孟 | Medicinal composition containing roxatidine |
| CN101797356B (en) * | 2009-12-30 | 2011-06-15 | 李孟 | Traditional Chinese medicine and Western medicine composition containing Lafutidine |
| CN101721657B (en) * | 2009-12-30 | 2011-06-15 | 叶希友 | Chinese and western medicine composition containing licorzinc |
| CN101797364B (en) * | 2010-04-15 | 2011-06-15 | 叶希友 | Marzulene-s-containing combined medicine |
| CN101810828B (en) * | 2010-04-15 | 2011-08-31 | 罗丹晓 | Combination medicament containing teprenone |
| CN105055342A (en) * | 2015-08-13 | 2015-11-18 | 青岛蓝盛洋医药生物科技有限责任公司 | Sodium ilaprazole medicine composition freeze-dried powder injection for treating peptic ulcer |
| CN105055343A (en) * | 2015-08-31 | 2015-11-18 | 青岛蓝盛洋医药生物科技有限责任公司 | Ilaprazole sodium composition freeze-dried powder injection serving as medicine for treating stomach diseases |
-
2007
- 2007-06-05 CN CNB200710105984XA patent/CN100515484C/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| 中西药结合治疗消化性溃疡的临床研究. 顾萍等.南京中医药大学学报，第20卷第3期. 2004 |
| 中西药结合治疗消化性溃疡的临床研究. 顾萍等.南京中医药大学学报，第20卷第3期. 2004 * |
| 西药联用中药消溃平汤剂治疗消化性溃疡53例. 赖四海等.现代中西医结合杂志，第16卷第12期. 2007 |
| 西药联用中药消溃平汤剂治疗消化性溃疡53例. 赖四海等.现代中西医结合杂志，第16卷第12期. 2007 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732663B (en) * | 2009-12-30 | 2011-11-02 | 宁波市鄞州奥胜生物科技有限公司 | Rebamipide-containing Chinese and western medicinal composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101066435A (en) | 2007-11-07 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090722 Termination date: 20100605 |