CN101732663B - Rebamipide-containing Chinese and western medicinal composition - Google Patents
Rebamipide-containing Chinese and western medicinal composition Download PDFInfo
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- CN101732663B CN101732663B CN2009102444218A CN200910244421A CN101732663B CN 101732663 B CN101732663 B CN 101732663B CN 2009102444218 A CN2009102444218 A CN 2009102444218A CN 200910244421 A CN200910244421 A CN 200910244421A CN 101732663 B CN101732663 B CN 101732663B
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Abstract
The invention discloses a rebamipide-containing and Chinese medicinal extract-containing cooperative medicinal composition, and application of the composition in preparing a medicament for treating gastric ulcer.
Description
The present invention relates to a kind of medicine for the treatment of gastropathy, is the compositions of being made by Chinese crude drug extract and Western medicine, is particularly suitable for the medicine as treatment gastritis, peptic ulcer gastropathy such as (containing gastric ulcer and duodenal bulbar ulcer).
Gastropathy, particularly gastritis (shallow harmony in the exterior atrophic), peptic ulcer (containing gastric ulcer and duodenal bulbar ulcer) is a kind of commonly encountered diseases, frequently-occurring disease.At present, the medicine for the treatment of these diseases is more, the curative effect of the degree of having nothing in common with each other, but generally speaking, curative effect is not ideal enough, and relapse rate is higher after the drug withdrawal, and with regard to better medicine at present commonly used: its effective percentage is below 80%, and its relapse rate is more than 36%.
Purpose of the present invention just is: invent a kind of composition medicine of being made up of Chinese medicine extract and Western medicine for the treatment of gastropathy, to improve the treatment curative effect and to reduce relapse rate.
The present invention realizes its purpose like this: the present composition comprises Chinese medicine extract and Western medicine, and wherein Chinese medicine extract is prepared by following method:
Chinese medicine medical material component and proportional quantity thereof, % counts with percentage ratio:
Rhizoma Alpiniae Officinarum 4, the Radix Aucklandiae 3, Os Sepiae 3, Rhizoma Curcumae 10, Amomum globosum loureiro 1,
Radix Et Rhizoma Nardostachyos 6, dried Alumen 3, Endothelium Corneum Gigeriae Galli 3, Rhizoma Coptidis 3, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10,
Rhizoma Corydalis 11, Fructus Hordei Germinatus 1, Radix Aristolochiae 20, Semen Trichosanthis 2, Corium elephatis 20,
The summation of its each component is 100%.
Earlier Chinese crude drug is cleaned, press the proportional quantity metering, and medical material is concocted with conventional concocting method, be ground into powder, decoct with water, filtration, concentrated filtrate is to thick paste, drying.
Pharmaceutical composition Chinese medicine and western medicine of the present invention in addition is a rebamipide, and the weight ratio of Chinese medicine extract and Western medicine is 56: 1.
Chinese medicine extract prescription in the pharmaceutical composition of the present invention is from the embodiment 1 of CN1055015C.
Pharmaceutical composition of the present invention can be made into various peroral dosage forms, and three times on the one, each 2 grams, seriously ill person's four times a day, boiled water is taken after mixing it with water.For gastritis (shallow table or atrophic), 7 is a course of treatment, serve on 2-3 the course of treatment, and for peptic ulcer (containing gastric ulcer and bulboduodenal ulcer), be a course of treatment January, serve on 2-3 the course of treatment.Taboo: dry peppery, the raw food food such as hard of fasting.
Clinical effectiveness:
To peptic ulcer (containing gastric ulcer and duodenal bulbar ulcer) 40 examples, treat 5 courses of treatment after.Through hospital's fiber microscopy and biopsy, 18 examples of wherein fully recovering, effective 19 examples, invalid 3 examples.Average total effective rate is 92.5%, and the toxic side effect reaction is found at the end.And with the pure Chinese medicine extract or the rebamipide of Isodose, effective percentage is respectively 68% and 86%.
The treatment standard declaration: recovery from illness refers to after 2-3 the course of treatment 1 clinical symptom disappearance.Through fiber microscopy and biopsy, foci disappearance.Effectively refer to after 2～8 courses of treatment, through fiber microscopy and biopsy, clinical symptom disappearance, the lesion tissue scope is dwindled.Invalid finger is after 2-3 the course of treatment, and clinical symptoms does not have significant change before fiber microscopy and biopsy and treatment.
Pharmacology and resultant effect analysis.The Rhizoma Curcumae heat-clearing and toxic substances removing of this medicine with the same usefulness of Rhizoma Coptidis, strengthens heat-clearing toxin-expelling functions, Corium elephatis granulation promoting good medicine, and dried Alumen is held back skin ulcer, reuses poliosis, the same usefulness of three flavors, granulation promoting power is grand, and it is remarkable to hold back skin ulcer, promotes the lesion tissue reparation effectively, and well can end digestive tract hemorrhage preferably; Semen Trichosanthis a surname spleen helps circulation of qi promoting intestinal stasis relieving class efficacy of drugs such as Radix Et Rhizoma Nardostachyos more remarkable, has effectively promoted the recovery of gastric motility function, reuses Rhizoma Corydalis, Radix Aristolochiae, fast and effeciently pain relieving.Therefore, comprehensive compatibility, this Chinese patent medicine is heat-clearing and toxic substances removing effectively, and rebamipide can effectively be protected gastric mucosa.The Chinese medicine and western medicine binding energy fundamentally reaches therapeutic purposes.
Claims (2)
1. compositions for the treatment of gastric ulcer, said composition comprises Chinese medicine extract and Western medicine, and wherein Chinese medicine extract is prepared by following method:
Chinese medicine medical material component and proportional quantity thereof, % counts with percentage ratio:
Rhizoma Alpiniae Officinarum 4, the Radix Aucklandiae 3, Os Sepiae 3, Rhizoma Curcumae 10, Amomum globosum loureiro 1,
Radix Et Rhizoma Nardostachyos 6, dried Alumen 3, Endothelium Corneum Gigeriae Galli 3, Rhizoma Coptidis 3, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10,
Rhizoma Corydalis 11, Fructus Hordei Germinatus 1, Radix Aristolochiae 20, Semen Trichosanthis 2, Corium elephatis 20,
The summation of its each component is 100%,
Earlier Chinese crude drug is cleaned, press the proportional quantity metering, and medical material is concocted with conventional concocting method, be ground into powder, decoct with water, filtration, concentrated filtrate is to thick paste, drying;
Western medicine is a rebamipide in addition, and the weight ratio of Chinese medicine extract and Western medicine is 56: 1.
2. the purposes of compositions as claimed in claim 1 in the medicine of preparation treatment gastric ulcer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102444218A CN101732663B (en) | 2009-12-30 | 2009-12-30 | Rebamipide-containing Chinese and western medicinal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102444218A CN101732663B (en) | 2009-12-30 | 2009-12-30 | Rebamipide-containing Chinese and western medicinal composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101732663A CN101732663A (en) | 2010-06-16 |
| CN101732663B true CN101732663B (en) | 2011-11-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102444218A Expired - Fee Related CN101732663B (en) | 2009-12-30 | 2009-12-30 | Rebamipide-containing Chinese and western medicinal composition |
Country Status (1)
| Country | Link |
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| CN (1) | CN101732663B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055015C (en) * | 1997-10-21 | 2000-08-02 | 肖启美 | Weijisan for gastropathy |
| CN101066434A (en) * | 2007-06-05 | 2007-11-07 | 陈旭龙 | Omeprazole-containing medicine |
| CN101269200A (en) * | 2008-04-29 | 2008-09-24 | 乐亚 | Chinese-western medicine composition containing carafate for treating gastric ulcer |
| CN100515484C (en) * | 2007-06-05 | 2009-07-22 | 陈旭龙 | Iprazole containing medicine |
-
2009
- 2009-12-30 CN CN2009102444218A patent/CN101732663B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055015C (en) * | 1997-10-21 | 2000-08-02 | 肖启美 | Weijisan for gastropathy |
| CN101066434A (en) * | 2007-06-05 | 2007-11-07 | 陈旭龙 | Omeprazole-containing medicine |
| CN100515484C (en) * | 2007-06-05 | 2009-07-22 | 陈旭龙 | Iprazole containing medicine |
| CN101269200A (en) * | 2008-04-29 | 2008-09-24 | 乐亚 | Chinese-western medicine composition containing carafate for treating gastric ulcer |
Non-Patent Citations (1)
| Title |
|---|
| 岑永加等.慢性萎缩性胃炎中西医结合干预治疗48例.《现代中西医结合杂志》.2007,第16卷(第20期),2083-2084. * |
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| Publication number | Publication date |
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| CN101732663A (en) | 2010-06-16 |
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Owner name: NINGBO YINZHOU AOSHENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: ZHANG XIXIN Effective date: 20110810 |
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Inventor after: Xiao Yu Inventor after: Zhang Xixin Inventor before: Zhang Xixin |
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Free format text: CORRECT: ADDRESS; FROM: 100020 CHAOYANG, BEIJING TO: 315194 NINGBO, ZHEJIANG PROVINCE Free format text: CORRECT: INVENTOR; FROM: ZHANG XIXIN TO: XIAO YU ZHANG XIXIN |
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