CN105832828A - Preparation method of healthy-energy-strengthening and body-detoxifying ultrafine powder agent for livestock and poultry - Google Patents

Preparation method of healthy-energy-strengthening and body-detoxifying ultrafine powder agent for livestock and poultry Download PDF

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CN105832828A
CN105832828A CN201610181343.1A CN201610181343A CN105832828A CN 105832828 A CN105832828 A CN 105832828A CN 201610181343 A CN201610181343 A CN 201610181343A CN 105832828 A CN105832828 A CN 105832828A
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parts
medicine
powder
detoxifying
preparation
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胡学全
陈益德
秦斌
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SICHUAN DERUNTONG BIOTECHNOLOGY Co Ltd
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SICHUAN DERUNTONG BIOTECHNOLOGY Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a preparation method of a healthy-energy-strengthening and body-detoxifying ultrafine powder agent for livestock and poultry. The preparation method includes the steps of crushing the following raw materials including, by weight, 60 parts of radix isatidis, 60 parts of astragalus membranaceus, 30 parts of herba epimedii and 10-16 parts of rhubarb into ultrafine powders being less than 10 [mu]m in particle size, and mixing the ultrafine powders with 13-17 parts of pentaerythritol ultrafine powder to form the ultrafine powder agent. In the invention, the formula is improved, wherein the rhubarb generally used for purging body and eliminating accumulation, purging fire and detoxifying body is added to the powder agent. The rhubarb not causes diarrhea and dysentery of animals but has significant treatment effect on fever of animals. The ultrafine powder agent is prepared with a preferable special dispersion agent, so that the stable period of the product is improved, the product is free of moisture absorption and caking, is prolonged in shelf live, is reduced in cost and avoids resource waste, the formula is still simple and the powder agent has the original various functions of healthy-energy-strengthening and body-detoxifying powder.

Description

A kind of preparation method of poultry Fuzheng Jiedu superfine powder
The application is Application No.: 201410005571.4, and patent name is: " Fuzheng Jiedu of high stable surpasses Micropowder " the divisional application of patent of invention, the original bill applying date: on January 6th, 2014.
Technical field
The present invention relates to veterinary drug, be specifically related to Fuzheng Jiedu medicine, this medicine has enhancing poultry immunity of organism The effect of power, also has the effect of antipyretic antiviral simultaneously.
Background technology
2010 editions " Chinese veterinary pharmacopoeia " has " Fuzheng Jiedu powder " described in (being called for short: pharmacopeia 2010 editions), by Radix Isatidis 60g, Radix Astragali 60g form with Herba Epimedii 30g;Energy strengthening vital QI to eliminate pathogenic factors, heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI. Repairing immune cell function, induction body produces interferon, adjusts body's immunity;Protect the liver and protect kidney, solution Poison toxin expelling, the various secondary infection causing porcine circovirus have specially good effect.Cure mainly infectious bursal disease.Right The infectious disease that other virus causes is the most effective in cure.
Therefore clinic is except for infectious bursal disease.Also use as prophylactic agent, be used for improving poultry Immunity, prevent sub-health state from occurring, adjust animal body each organ functional status, make body be in Optimal physiological status, life-time service purifying aquaculture field viral disease.
Making of current almost all of antiviral chemical synthetic drug such as amantadine, ribavirin, moroxydine etc. With all being prohibited by the Ministry of Agriculture.Therefore, Traditional Chinese Medicine Anti virus becomes technology trends.In this context, Having and chicken, duck, the isometric conventional livestock and poultry virus sexually transmitted disease of pig are had extensive curative effect, formula is simple, and cost is relatively Low Fuzheng Jiedu powder becomes the focus that field of veterinary is researched and developed further.And current technology research direction master If improve the dosage form of Fuzheng Jiedu powder, preparation process improves its drug absorption and utilization rate, improve clinic Curative effect.Such as have and be prepared as oral liquid, have and be prepared as superfine powder.These technology all to this medicine Clinical application serves good facilitation;But only limited from dosage form and technologic room for improvement, difficult To realize technological break-through.
It addition, existing Fuzheng Jiedu powder yet suffers from the biggest deficiency clinically: as the righting solution of prophylactic Poison dissipates the best refrigeration function itself, does not improves significantly animal hyperpyrexia, fervescence;Must Antibiotic or other antipyretic analgesicses must be coordinated to use.Thus cause clinical animal isolation and the inconvenience of medication. If whereas if Fuzheng Jiedu powder can possess preferable refrigeration function, even if then certain facing occurs in animal Bed symptom, then because avoiding hyperpyrexia, high heat, so the preferable mental status, appetite substantially can be kept, And the regulation immunization combining Fuzheng Jiedu powder recovers and voluntarily without using antibiotic.Medication can be facilitated, Reduce again cost, and reduce drug dependence.
The technology the most not improving Fuzheng Jiedu powder refrigeration function is open.According to row Industry regulation does not the most allow antipyretic chemicals to add, and if add, healthy animal body can be caused to be forced to Absorb antipyretic, be not avoided that drug dependence.And add routine heat clearing Chinese medicine such as: Gypsum Fibrosum, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Flos Lonicerae, Radix Rehmanniae etc., be also difficult to reach good effect through overtesting;Or raising antipyretic response While the miopragia such as original antiviral, or formula is complex and existing anti virus herb difference is little ?.
The most such as add a small amount of raw material of Chinese medicine, carry on the premise of keeping formula simplification, the original effect of medicine The refrigeration function of high Fuzheng Jiedu powder, is one, this area technical barrier._
Summary of the invention
It is an object of the invention to provide the Fuzheng Jiedu superfine powder of a kind of high stable, this medicine has good steady Qualitative.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of Fuzheng Jiedu superfine powder of high stable, it is characterised in that: consisting of by weight: Baphicacanthus cusia Root 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 10-16 part;It is superfine powder that described medicine is pulverized, And mix tetramethylolmethane superfine powder 13-17 part and obtain superfine powder.
Preferably, described Radix Et Rhizoma Rhei 12 parts.
Preferably, described tetramethylolmethane superfine powder 15 parts.
Compared with prior art, the invention has the beneficial effects as follows:
1, improve formula, add the Radix Et Rhizoma Rhei being conventionally used for heat and toxic materials clearing away, eliminating fire and detoxication;Not only will not Cause animal to have loose bowels, dysentery;Heating paresthesia to animal plays significant curative effect on the contrary.
2, ensure human body energy and the vigor of animal, coordinate medicine itself to have enhancing immunization, can be notable Improving anti-virus ability, animal viral disease infection rate significantly reduces.Keep the good growth tendency of animal.
3, the use of antibiotic is decreased, it is to avoid poultry produce drug resistance and immunity reduces.Convenient clinic Medication, reduces the cost of cultivation.
4, preferably specific dispersant in superfine powder, can significantly improve the stable period of product, side's moisture absorption, Anti-caking, improves the medicine shelf-life, reduces medicine cost, it is to avoid the wasting of resources.
5, formula is the most relatively simple, and keeps the original various functions of Fuzheng Jiedu powder.
Therefore, the present invention can essentially be not understood as providing: has heat clearing away, improve poultry immunity of organism The Fuzheng Jiedu medicine of power, or heat-clearing and toxic substances removing antiviral powder agent medicine, or the Fuzheng Jiedu ultra micro of high stable Powder medicine.
Detailed description of the invention
Provide below preferred embodiment, so that those skilled in the art are more clear and the skill of the clear and definite present invention Art scheme and Advantageous Effects.But the enforcement of the present invention is not limited in the following example.Do not demonstrate,prove simultaneously The formula of the bright present invention is unique particular requirement, but allows rational equivalent and commercial production, faces The error of bed application.
Embodiment one
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 10 parts.Medicine material Jointly pulverize, cross No. five sieves, mix to obtain powder.
Embodiment two
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 12 parts.Medicine is respectively Pulverize No. five sieves, mix to obtain powder.
Embodiment three
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 16 parts.Medicine is respectively Pulverize No. five sieves, mix to obtain powder.
Embodiment four
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 12 parts.By walking as follows Suddenly oral liquid it is prepared as:
1) four Chinese medicine thing shreds below 2cm size, adds 1.2 times of weight water and soaks 30 minutes;
2) keep micro-boiling 1 hour after boiling, filter;
3) filtering residue adds micro-boiling 45 minutes after 1 times of weight water is boiled, and filters;
4) merge the filtrate of twice, be concentrated into and heavily and get final product with former medicine etc..
Embodiment five
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 13 parts.By walking as follows Suddenly oral liquid it is prepared as:
1) four Chinese medicine thing shreds below 2cm size, adds 1.2 times of weight water and soaks 30 minutes;
2) keep micro-boiling 1 hour after boiling, filter;
3) filtering residue adds micro-boiling 45 minutes after 1 times of weight water is boiled, and filters;
4) merge the filtrate of twice, be concentrated into and heavily and get final product with former medicine etc..
Embodiment six
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 12 parts.Described medicine Thing is pulverized as superfine powder (below particle diameter 10 μm), and mix tetramethylolmethane superfine powder (particle diameter 10 μm with Under) 15 parts obtain superfine powder.
Embodiment seven
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 13 parts.Described medicine Thing is pulverized as superfine powder (below particle diameter 10 μm), and mix tetramethylolmethane superfine powder (particle diameter 10 μm with Under) 16 parts obtain superfine powder.
Comparative example one
Dispersant: tetramethylolmethane superfine powder (below particle diameter 10 μm) 8 parts, remaining is with embodiment six.
Comparative example two
Dispersant: tetramethylolmethane superfine powder (below particle diameter 10 μm) 20 parts, remaining is with embodiment six.
Comparative example three
Dispersant: microcrystalline Cellulose (below particle diameter 10 μm) 15 parts, remaining is with embodiment six.
Comparative example four
Dispersant: starch (below particle diameter 10 μm) 15 parts, remaining is with embodiment six.
Comparative example five
Dispersant: calcium hydrogen phosphate (below particle diameter 10 μm) 15 parts, remaining is with embodiment six.
Stability test
1. materials and methods: the Fuzheng Jiedu medicine of Example one to seven, according to " Chinese veterinary pharmacopoeia " 2010 Year one annex medicine stability experimental technique of version carries out hot and humid high light Acceleration study, by commercially available back, At temperature 40 ± 2 DEG C, relative humidity 75 ± 5%, the medicine stability experimental box (weight of illumination 4500 ± 500LX Celebrating immortality experimental apparatus factory) in place 6 months, take respectively at the 1st, 2,3,6 the end of month of period testing The character of powder, content, granularity, appearance uniform degree, sedimentation volume ratio, redispersibility once, are entered by sample Row is investigated, and result is the most qualified.Because the safety and stability of conventional Chinese medicine is more reliable, the present invention The medication taboo general knowledge the most not gone against the established rules, therefore test data in detail repeats no more.
2. superfine powder medicine stability contrast
Totally 7 groups of medicines of embodiment six, seven and comparative example one to five are being tested period the 1st, 2,3,6 The end of month is separately sampled once, contrasts caking situation, water absorption rate, fineness situation, test data such as table 1 below institute Show.
The stability experiment data of table 1 superfine powder
Visible, the present invention uses the tetramethylolmethane superfine powder superfine powder of specified weight to do dispersant, and superfine powder is steady Qualitative significantly improve.
Veterinary clinic application effect
1. pair infectious bursal disease curative effect
Choose the morbidity chicken group of Hechuan, Chongqing, area, Tongnan plant, therefrom select and do not used any medicine Treatment, by clinical observation, laboratory diagnosis be diagnosed as the broiler 250 of infectious bursal disease, at random It is divided into 5 groups, often group 50.
Test group 1 adds the Fuzheng Jiedu medicine that embodiment 2 prepares in feedstuff;
Test group 2 adds the Fuzheng Jiedu medicine that embodiment 4 prepares in feedstuff;
Test group 3 adds the Fuzheng Jiedu medicine that embodiment 6 prepares in feedstuff;
Test group 4 adds the Fuzheng Jiedu medicine that embodiment 7 prepares in feedstuff;
Matched group 1 adds the Fuzheng Jiedu medicine by pharmacopeia 2010 editions preparation in feedstuff.
Mixed feeding in the quantity set of 1g is all given every day by every chicken;Each continuous use 3 days, stops observation post administration 1 Week.
Curative effect judging standard
Cure: test chicken be administered after, lassitude, suffer from diarrhoea, arrange faint yellow or linen not sample loose stool, The clinical symptoms such as dehydration all disappear;And spirit, appetite, feces, breathing etc. recover normal for curing.
Effective: all during testing, after chicken medication, the spirit of test chicken, appetite, breathing be clearly better into Effectively.
Invalid: during test, there is classical symptom the death of infectious bursal disease in test chicken, and corpse cuts open After inspection, visible chest muscle, lower limb flesh, glandular stomach, kidney and bursal disease etc. have typical feature disease to become, and all can determine that Do not alleviate for infecting death or symptom or continue to deteriorate as invalid.
Experimental result is as shown in the table:
Experimental group does not increase dysentery, the case of symptom of having loose bowels newly.The Fuzheng Jiedu medicine of the present invention as can be seen here Effect in terms for the treatment of chicken bursal disease is no less than existing powder effect.And add Radix Et Rhizoma Rhei also without result in The side effect such as chicken has loose bowels.
2. refrigeration function effect
Choose that Hechuan large-scale hoggery feeding and management condition is essentially identical, age in days is close in birth, swine fever or pig stream Row cold, fever, body temperature, 39.0 ± 5 DEG C of cases 57, is randomly divided into 3 groups, often group 19.
Experimental group one: add the Fuzheng Jiedu medicine that embodiment 6 prepares in feedstuff by per kilogram of body weight every day The ratio of 1g feeds, and disposably feeds intake;
Experimental group one: add the Fuzheng Jiedu medicine that embodiment 7 prepares in feedstuff by per kilogram of body weight every day The ratio of 1g feeds, and disposably feeds intake;
Matched group one: add 5g 10% tilmicosin pre-mixing agent in feedstuff by per kilogram of body weight every day, 1g presses The Fuzheng Jiedu medicine of pharmacopeia 2010 editions preparation, disposably feeds intake;
Matched group two: add the 1g righting by pharmacopeia 2010 editions preparation in feedstuff by per kilogram of body weight every day Antidote, disposably feeds intake.
Other conditions such as each group uses 3 days the most continuously, feeding and management are identical.Then 2 little after feeding for the first time Time, 24 hours, 48 hours, 72 hours, 144 hours measure anus temperature, record data, result see table:
Swine fever or the antipyretic result of the test of swine influenza fever patients (DEG C, ± S)
It can be seen that after 2 hours, use the temperature of pig body of medicine of the present invention to be decreased obviously, within 24 hours, return to Normal level.The test group using tilmicosin pre-mixing agent and existing Fuzheng Jiedu medicine shows and the present invention The performance that medicine is suitable.Use merely existing Fuzheng Jiedu medicine then sick temperature of pig body the most substantially treat with Improve effect.The sick body of two test group can refresh state and appetite substantially in 24 hours, nothing Other antibiotic or antiviral drugs need to be used to fully recover voluntarily.Advantageously promote animal recover the most afterwards and give birth to Long.Reduce antibiotic usage.And experimental group 1,2 does not the most increase dysentery case newly.The sick body of matched group two is all Need to use antibiotic therapy to fully recover, and have an example Relapse rate dead.
Additionally to 1355 chickens of chicken house, by once a day in feedstuff, each per kilogram of body weight 0.5g pre- Anti-consumption feeds;Matched group 1200 is only without medicine, in the case of other condition is identical.Experimental group chicken Infectious bursal disease morbidity example is 5.02%, and matched group is 31%.Same scale of feeding is identical in other condition In the case of, experimental group swine influenza sickness rate is 1.62%, and matched group is 23%.The most do not occur because of The phenomenon suffered from diarrhoea for medication, draw tripe symptom to increase, it is seen that the medicine of the present invention can regulate animal body immunity Power, strengthens anti-virus ability.

Claims (3)

1. the preparation method of a poultry Fuzheng Jiedu superfine powder, it is characterised in that: by weight by 60 Part Radix Isatidis, 60 parts of Radixs Astragali, 30 parts of Herba Epimedii, 10~16 parts of Radix Et Rhizoma Rhei pulverizing are particle diameter surpassing less than 10 μm Micropowder, then 13~17 parts of tetramethylolmethane superfine powder of mixing obtain superfine powder.
The preparation method of a kind of poultry Fuzheng Jiedu superfine powder the most according to claim 1, its feature It is: described Radix Et Rhizoma Rhei 13 parts.
The preparation method of a kind of poultry Fuzheng Jiedu superfine powder the most according to claim 1, its feature It is: described tetramethylolmethane superfine powder 16 parts.
CN201610181343.1A 2014-01-06 2014-01-06 Preparation method of healthy-energy-strengthening and body-detoxifying ultrafine powder agent for livestock and poultry Pending CN105832828A (en)

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CN110051735A (en) * 2019-04-30 2019-07-26 河北维尔利动物药业集团有限公司 Livestock and poultry Fuzheng Jiedu broken wall superfine powder and its preparation process

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