CN103054985A - Pure Chinese medicinal composition for treating red fin disease of eels and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating red fin disease of eels and preparation method of pure Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating the red fin disease of eels. The pure Chinese medicinal composition is prepared by mixing the following components in part by weight: 25 to 45 parts of houttuynia cordata, 15 to 40 parts of Chinese knotweed herb, 15 to 35 parts of red-knees herb, 15 to 35 parts of licorice root, 15 to 35 parts of indigowoad root, 15 to 35 parts of hedyotis diffusa, 10 to 20 parts of salt, 20 to 40 parts of dried orange peel, 20 to 40 parts of plantain herb and 20 to 40 parts of lonicera japonica. The invention has the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of toxic or side effects, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability, can treat both symptoms and root causes and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the red fin disease of the eels.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of the Anguillar japonica red fin fish disease and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment Anguillar japonica red fin fish disease and preparation method thereof.
Background technology
The Anguillar japonica red fin fish disease is a kind ofly to have that spread speed is fast, relapse rate is high by what Aeromonas hydrophila caused, and the easy deadly infectious disease of other bacterial disease of secondary.Sick eel anal fin, pectoral fin are rubescent, and the veutro skin of trunk and head has hemorrhage and ecchymosis, and above-mentioned position is all rubescent when serious, even trunk back and dorsal fin also take on a red color.Sick eel does not eat food, and near the pool wall transfixion, the head that has upwards " erects trip " feebly, and is most dead in several days.The sick eel intestinal of anatomic observation is congested, rubescent, and liver congestion is kermesinus, the kidney enlargement.Cultivation causes serious economic loss to this disease to the Anguillar japonica class.
This disease almost spreads all over all eel culture countries of the world, is widely distributed.The primary disease western medicine mainly uses antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese prescription for the treatment of the Anguillar japonica red fin fish disease, micronizing, bioavailability height, the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simply, micronizing, high, the treating both the principal and secondary aspects of a disease of bioavailability, pure Chinese medicine composition of effective treatment Anguillar japonica red fin fish disease of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of the Anguillar japonica red fin fish disease, by following component by weight mixed preparing form: Herba Houttuyniae 25-45 part, Herb Polygoni Chinensis 15-40 part, Herba polygoni hydropiperis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Isatidis 15-35 part, Herba Hedyotidis Diffusae 15-35 part, Sal 10-20 part, Pericarpium Citri Reticulatae 20-40 part, Herba Plantaginis 20-40 part, Flos Lonicerae 20-40 part.
Described various component optimum ratio amount is: 35 parts of Herba Houttuyniae, 25 parts of Herb Polygoni Chinensiss, 25 parts of Herba polygoni hydropiperis, 25 parts in Radix Glycyrrhizae, 25 parts of Radix Isatidis, 25 parts of Herba Hedyotidis Diffusaes, 15 parts of Sal, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Herba Plantaginiss, 30 parts of Flos Loniceraes.
A kind of preparation method for the treatment of the pure Chinese medicine composition of Anguillar japonica red fin fish disease, carry out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Herba Houttuyniae 25-45 part, Herb Polygoni Chinensis 15-40 part, Herba polygoni hydropiperis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Isatidis 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Herba Hedyotidis Diffusae 15-35 part, Sal 10-20 part, Pericarpium Citri Reticulatae 20-40 part, Herba Plantaginis 20-40 part, Flos Lonicerae 20-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Herba Houttuyniae: hot, be slightly cold, return lung meridian, have the functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
The Herb Polygoni Chinensis: sour, puckery, cool, return liver, large intestine channel, have heat-clearing and toxic substances removing, the antipruritic function of dampness removing; Cure mainly hygropyretic dysentery, eczema etc.
Herba polygoni hydropiperis: hot, warm, return lung, liver, large intestine channel, have the function of detoxifcation, damp eliminating, dissipating blood stasis, hemostasis; Cure mainly dysentery, rheumatic arthralgia, carbuncle furuncle, eczema, traumatic hemorrhage etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Herba Hedyotidis Diffusae: bitter, sweet, cold, GUIXIN, liver, spleen channel have the functions such as heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema, cure mainly laryngopharynx swelling and pain, dyspnea and cough due to lung-heat, the puckery pain of pyretic stranguria, jaundice due to damp-heat, venom, the swollen hot carbuncle of skin ulcer etc.
Sal: cold, become, return stomach, kidney, lung, liver, large intestine, small intestine meridian, have heat-clearing and toxic substances removing, removing heat from blood, softening the hard mass, parasite killing, antipruritic function; Cure mainly trusted subordinate's distension syndrome, constipation and anuresis, hemorrhage, skin infection etc.
Pericarpium Citri Reticulatae: bitter, hot, warm, return lung, spleen channel, have the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly that poor appetite, stomachache, tripe expand, have loose bowels, productive cough due to phlegm-damp etc.
Herba Plantaginis: sweet, cold, return lung, kidney, liver, small intestine meridian, have clearing away heat and promoting diuresis, eliminate the phlegm, the function of removing heat from blood, detoxifcation; Cure mainly that pyretic stranguria, short urination are red, diarrhea due to damp-heat, phlegm-heat cough, carbuncle sore tumefacting virus etc.
Flos Lonicerae: sweet, cold, attach to the lung and stomach meridians, have the function of heat-clearing and toxic substances removing, heat radiation dispelling wind; Cure mainly cough due to lung-heat, epidemic febrile disease heating, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
More than all herbal medicines according to the theoretical compatible combination of Chinese veterinarian, for paathogenic factor and the clinical symptoms of Anguillar japonica red fin fish disease, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, and it is wide to draw materials, micronizing, bioavailability height, curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this ten herbal medicine, and they are formed according to optimum ratio, and clinical practice proves that treatment Anguillar japonica red fin fish disease is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of the red fin of Anguillar japonica and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of Herba Houttuyniae, 150 parts of Herb Polygoni Chinensiss, 150 parts of Herba polygoni hydropiperis, 150 parts in Radix Glycyrrhizae, 150 parts of Radix Isatidis, mix 5-10 minute to even;
(3) take by weighing by weight 150 parts of Herba Hedyotidis Diffusaes, 100 parts of Sal, 200 parts of Pericarpium Citri Reticulataes, 200 parts of Herba Plantaginiss, 200 parts of Flos Loniceraes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of the Anguillar japonica red fin fish disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of Herba Houttuyniae, 300 parts of Herb Polygoni Chinensiss, 250 parts of Herba polygoni hydropiperis, 250 parts in Radix Glycyrrhizae, 250 parts of Radix Isatidis, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Herba Hedyotidis Diffusaes, 150 parts of Sal, 300 parts of Pericarpium Citri Reticulataes, 300 parts of Herba Plantaginiss, 300 parts of Flos Loniceraes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of the Anguillar japonica red fin fish disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 450 parts of Herba Houttuyniae, 400 parts of Herb Polygoni Chinensiss, 350 parts of Herba polygoni hydropiperis, 350 parts in Radix Glycyrrhizae, 350 parts of Radix Isatidis, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Herba Hedyotidis Diffusaes, 200 parts of Sal, 400 parts of Pericarpium Citri Reticulataes, 400 parts of Herba Plantaginiss, 400 parts of Flos Loniceraes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
The clinical experiment animal selects 300 ages in days, body weight at 0.08kg-0.1kg, and Laboratory Diagnosed is the ill fish of Anguillar japonica red fin fish disease.Ill fish isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 60 tails, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " eel Yukangsan " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes bait feeding in 2.5% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the applicable cases contrast of the present invention and other medicines treatment Anguillar japonica red fin fish disease:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 23.3 | 52.7 | 40.0 |
| II | Eel Yukangsan group | 10.0 | 76.7 | 13.3 |
| III | Present composition group | 6.7 | 86.6 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with eel Yukangsan group aspect the cure rate.
Safety testing:
Choose healthy Anguillar japonica 30 tails of 80 ages in days, 5 times according to the embodiment of the invention 1 made compositions recommended dose took orally 10 days, during the medication, any bad or Deviant Behavior performance does not appear in healthy fish, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment Anguillar japonica red fin fish disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of the Anguillar japonica red fin fish disease, it is characterized in that by following component by weight mixed preparing form: Herba Houttuyniae 25-45 part, Herb Polygoni Chinensis 15-40 part, Herba polygoni hydropiperis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Isatidis 15-35 part, Herba Hedyotidis Diffusae 15-35 part, Sal 10-20 part, Pericarpium Citri Reticulatae 20-40 part, Herba Plantaginis 20-40 part, Flos Lonicerae 20-40 part.
2. the pure Chinese medicine composition for the treatment of according to claim 1 Anguillar japonica red fin fish disease, it is characterized in that by following component by weight mixed preparing form: 35 parts of Herba Houttuyniae, 25 parts of Herb Polygoni Chinensiss, 25 parts of Herba polygoni hydropiperis, 25 parts in Radix Glycyrrhizae, 25 parts of Radix Isatidis, 25 parts of Herba Hedyotidis Diffusaes, 15 parts of Sal, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Herba Plantaginiss, 30 parts of Flos Loniceraes.
3. the preparation method of the pure Chinese medicine composition of a treatment according to claim 1 and 2 Anguillar japonica red fin fish disease is characterized in that carrying out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Herba Houttuyniae 25-45 part, Herb Polygoni Chinensis 15-40 part, Herba polygoni hydropiperis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Isatidis 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Herba Hedyotidis Diffusae 15-35 part, Sal 10-20 part, Pericarpium Citri Reticulatae 20-40 part, Herba Plantaginis 20-40 part, Flos Lonicerae 20-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435423A (en) * | 2014-11-13 | 2015-03-25 | 桂东县华溪石蛙养殖专业合作社 | Traditional Chinese medicine composition for preventing and treating skin disease of rana spinosa and preparation method of traditional Chinese medicine composition |
| CN106214819A (en) * | 2016-08-30 | 2016-12-14 | 澧县玖久养蜂专业合作社 | The medicine for the treatment of ascospherosis of bee |
| CN107875254A (en) * | 2017-12-19 | 2018-04-06 | 长春市水产品质量安全检测中心 | A kind of Chinese medicine additive for preventing and treating loach fin rot |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102524526A (en) * | 2012-02-03 | 2012-07-04 | 湖北武当生物医药科技有限公司 | Traditional Chinese medicine vegetable feed additive containing honeysuckle and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102524526A (en) * | 2012-02-03 | 2012-07-04 | 湖北武当生物医药科技有限公司 | Traditional Chinese medicine vegetable feed additive containing honeysuckle and preparation method thereof |
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| 丁信: "防治鱼病小验方", 《农村天地》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435423A (en) * | 2014-11-13 | 2015-03-25 | 桂东县华溪石蛙养殖专业合作社 | Traditional Chinese medicine composition for preventing and treating skin disease of rana spinosa and preparation method of traditional Chinese medicine composition |
| CN104435423B (en) * | 2014-11-13 | 2017-12-29 | 桂东县华溪石蛙养殖专业合作社 | Prevent and treat dermopathic Chinese medicine composition of the stone frog and preparation method thereof |
| CN106214819A (en) * | 2016-08-30 | 2016-12-14 | 澧县玖久养蜂专业合作社 | The medicine for the treatment of ascospherosis of bee |
| CN107875254A (en) * | 2017-12-19 | 2018-04-06 | 长春市水产品质量安全检测中心 | A kind of Chinese medicine additive for preventing and treating loach fin rot |
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