CN105726660A - Body resistance strengthening and toxin removing ultrafine powder for livestock and poultry - Google Patents
Body resistance strengthening and toxin removing ultrafine powder for livestock and poultry Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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Abstract
The invention discloses body resistance strengthening and toxin removing ultrafine powder for livestock and poultry. The ultrafine powder is characterized by being prepared from the following raw materials in parts by weight: 60 parts of indigowoad root, 60 parts of radix astragali, 30 parts of epimedium herb, 10-16 parts of rhubarb and 13-17 parts of pentaerythritol ultrafine powder. The ultrafine powder has the beneficial effects that the formula is improved and rhubarb conventionally used for treating retention by purgation and purging fire for removing toxins is added, so that not only can the ultrafine powder not cause diarrhea and dysentery of animals but also the ultrafine powder has obvious curative effects on fever symptoms of animals; preferentially selected in the ultrafine powder, the specific dispersing agent can conduce to obviously increasing the stable period of the product, is resistant to moisture absorption and caking and has the effects of increasing the shelf life of the drug, reducing the cost of the drug and avoiding resource waste; and the formula is still simpler and maintains the original functions of body resistance strengthening and toxin removing powder.
Description
The application is application number: 201410005571.4, and patent name is: the divisional application of the patent of invention of " the Fuzheng Jiedu superfine powder of high stable ", the original bill applying date: on January 6th, 2014.
Technical field
The present invention relates to veterinary drug, be specifically related to Fuzheng Jiedu medicine, this medicine has the effect strengthening poultry immunity of organisms, also has the effect of antipyretic antiviral simultaneously.
Background technology
2010 editions " Chinese veterinary pharmacopoeia " records " Fuzheng Jiedu powder " in (being called for short: pharmacopeia 2010 editions), is made up of Radix Isatidis 60g, Radix Astragali 60g and Herba Epimedii 30g；Energy strengthening vital QI to eliminate pathogenic factors, heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI.Repairing immune cell function, induction body produces interferon, adjusts body's immunity；Protecting the liver and protect kidney, detoxication and toxicant eliminating function, the various secondary infection that porcine circovirus is caused have specially good effect.Cure mainly infectious bursal disease.The infectious disease that other virus is caused is all effective in cure.
Therefore clinic is except for infectious bursal disease.Also use as prophylactic agent, for improving the immunity of poultry, preventing sub-health state from occurring, adjust each organ functional status of animal body, make body be in best physiological status, life-time service purifying aquaculture field viral disease.
The current almost all of antiviral chemical synthetic drug such as use of amantadine, ribavirin, moroxydine etc. is affected by the Ministry of Agriculture and prohibites.Therefore, Traditional Chinese Medicine Anti virus becomes technology trends.In this context, having and chicken, duck, the isometric conventional livestock and poultry virus sexually transmitted disease of pig are had extensive curative effect, formula is simple, and lower-cost Fuzheng Jiedu powder becomes the focus that field of veterinary is researched and developed further.And current technology research direction mainly improves the dosage form of Fuzheng Jiedu powder, preparation process improves its drug absorption and utilization rate, improve clinical efficacy.Such as there is preparation for oral liquid, have preparation for superfine powder.The application in clinic of this medicine is all served good facilitation by these technology；But it is only limited from dosage form and technologic room for improvement, it is difficult to realize technological break-through.
It addition, existing Fuzheng Jiedu powder yet suffers from very big deficiency clinically: the Fuzheng Jiedu powder itself as prophylactic does not have good refrigeration function, and animal hyperpyrexia, fervescence are not improved significantly；Antibiotic or other antipyretic analgesicses must be coordinated to use.Thus cause the inconvenience of clinical animal isolation and medication.Otherwise, if if Fuzheng Jiedu powder can possess good refrigeration function, even if then there is certain clinical symptoms in animal, then because avoiding hyperpyrexia, high heat, so substantially can keep the good mental status, appetite, and the adjustment immunization in conjunction with Fuzheng Jiedu powder recovers voluntarily without using antibiotic.Medication can be facilitated, reduce again cost, and reduce drug dependence.
Open but without the technology improving Fuzheng Jiedu powder refrigeration function in the art.Antipyretic chemicals is not allowed to add according to industry regulation yet, and if add, healthy animal body can be caused to be forced to absorb antipyretic, be not avoided that drug dependence.And add conventional heat clearing Chinese medicine such as: Gypsum Fibrosum, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Flos Lonicerae, Radix Rehmanniae etc., also it is difficult to reach good effect through overtesting；Or improve while antipyretic response the miopragias such as original antiviral, or formula is complex and existing anti virus herb difference is little.
Therefore as added a small amount of raw material of Chinese medicine, under the premise keeping formula simplification, the original effect of medicine, improve the refrigeration function of Fuzheng Jiedu powder, be one, this area technical barrier._
Summary of the invention
It is an object of the invention to provide the Fuzheng Jiedu superfine powder of a kind of high stable, this medicine has good stability.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of Fuzheng Jiedu superfine powder of high stable, it is characterised in that: consisting of by weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 10-16 part；Described medicine is pulverized as superfine powder, and mixes tetramethylolmethane superfine powder 13-17 part and obtain superfine powder.
Preferably, described Radix Et Rhizoma Rhei 12 parts.
Preferably, described tetramethylolmethane superfine powder 15 parts.
Compared with prior art, the invention has the beneficial effects as follows:
1, improve formula, add the Radix Et Rhizoma Rhei being conventionally used for heat and toxic materials clearing away, eliminating fire and detoxication；Not only be not result in animal have loose bowels, dysentery；On the contrary the heating paresthesia of animal is played significant curative effect.
2, ensureing human body energy and the vigor of animal, coordinate medicine itself to have enhancing immunization, can significantly improve anti-virus ability, animal viral disease infection rate significantly reduces.Keep the good growth tendency of animal.
3, antibiotic use is decreased, it is to avoid poultry produce drug resistance and immunity reduces.Facilitate clinical application, reduce the cost of cultivation.
4, preferred specific dispersant in superfine powder, it is possible to significantly improve the stable period of product, the side moisture absorption, anti-caking, improve the medicine shelf-life, reduce medicine cost, it is to avoid the wasting of resources.
5, formula is still relatively simple, and keeps the original various functions of Fuzheng Jiedu powder.
Therefore, the present invention can essentially be not understood as providing: has heat clearing away, improve the Fuzheng Jiedu medicine of poultry immunity of organisms, or heat-clearing and toxic substances removing antiviral powder agent medicine, or the Fuzheng Jiedu superfine powder medicine of high stable.
Detailed description of the invention
Provide below preferred embodiment so that those skilled in the art clearly with clear and definite technical scheme and Advantageous Effects.But the enforcement of the present invention is not limited in the following example.The formula simultaneously also not proving the present invention is unique particular requirement, and allows for reasonably equivalent replacement and the error of commercial production, clinical practice.
Embodiment one
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 10 parts.Medicine material is jointly pulverized, crosses No. five sieves, is mixed to obtain powder.
Embodiment two
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 12 parts.Medicine was pulverized No. five sieves respectively, was mixed to obtain powder.
Embodiment three
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 16 parts.Medicine was pulverized No. five sieves respectively, was mixed to obtain powder.
Embodiment four
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 12 parts.It is oral liquid by following steps preparation:
1) four Chinese medicine thing shreds below 2cm size, adds 1.2 times of weight water and soaks 30 minutes；
2) keep micro-after boiling to boil 1 hour, filter；
3) filtering residue adds micro-after 1 times of weight water is boiled boiling 45 minutes, filters；
4) merge the filtrate of twice, be concentrated into and heavily and get final product with former medicine etc..
Embodiment five
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 13 parts.It is oral liquid by following steps preparation:
1) four Chinese medicine thing shreds below 2cm size, adds 1.2 times of weight water and soaks 30 minutes；
2) keep micro-after boiling to boil 1 hour, filter；
3) filtering residue adds micro-after 1 times of weight water is boiled boiling 45 minutes, filters；
4) merge the filtrate of twice, be concentrated into and heavily and get final product with former medicine etc..
Embodiment six
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 12 parts.Described medicine is pulverized as superfine powder (particle diameter less than 10 μm), and mixes tetramethylolmethane superfine powder (particle diameter less than 10 μm) 15 parts and obtain superfine powder.
Embodiment seven
By weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30, Radix Et Rhizoma Rhei 13 parts.Described medicine is pulverized as superfine powder (particle diameter less than 10 μm), and mixes tetramethylolmethane superfine powder (particle diameter less than 10 μm) 16 parts and obtain superfine powder.
Comparative example one
Dispersant: tetramethylolmethane superfine powder (particle diameter less than 10 μm) 8 parts, all the other are with embodiment six.
Comparative example two
Dispersant: tetramethylolmethane superfine powder (particle diameter less than 10 μm) 20 parts, all the other are with embodiment six.
Comparative example three
Dispersant: microcrystalline Cellulose (particle diameter less than 10 μm) 15 parts, all the other are with embodiment six.
Comparative example four
Dispersant: starch (particle diameter less than 10 μm) 15 parts, all the other are with embodiment six.
Comparative example five
Dispersant: calcium hydrogen phosphate (particle diameter less than 10 μm) 15 parts, all the other are with embodiment six.
Stability test
1. materials and methods: the Fuzheng Jiedu medicine of Example one to seven, hot and humid high light Acceleration study is carried out according to one annex medicine stability experimental technique of " Chinese veterinary pharmacopoeia " version in 2010, by commercially available back, temperature 40 ± 2 DEG C, relative humidity 75 ± 5%, the medicine stability experimental box (Chongqing immortality experimental apparatus factory) of illumination 4500 ± 500LX is placed 6 months, testing period the 1st, 2, 3, 6 the end of month are separately sampled once, character to powder, content, granularity, appearance uniform degree, sedimentation volume ratio, redispersibility is investigated, result is all qualified.Because the safety and stability of conventional Chinese medicine is comparatively reliable, the present invention is also without the medication taboo general knowledge gone against the established rules, therefore test data repeats no more in detail.
2. superfine powder medicine stability contrast
To totally 7 groups of medicines of embodiment six, seven and comparative example one to five to test the 1st, 2,3,6 the end of month of period separately sampled once, contrasting caking situation, water absorption rate, fineness situation, test data is as shown in table 1 below.
The stability experiment data of table 1 superfine powder
Visible, the present invention adopts the tetramethylolmethane superfine powder superfine powder of specified weight to do dispersant, and superfine powder stability significantly improves.
Veterinary clinic application effect
1. pair infectious bursal disease curative effect
Choose the morbidity chicken group of Hechuan, Chongqing, area, Tongnan plant, therefrom select do not used any Drug therapy, by clinical observation, laboratory diagnosis be diagnosed as the broiler 250 of infectious bursal disease, be randomly divided into 5 groups, often group 50.
Test group 1 adds the Fuzheng Jiedu medicine that embodiment 2 prepares in feedstuff；
Test group 2 adds the Fuzheng Jiedu medicine that embodiment 4 prepares in feedstuff；
Test group 3 adds the Fuzheng Jiedu medicine that embodiment 6 prepares in feedstuff；
Test group 4 adds the Fuzheng Jiedu medicine that embodiment 7 prepares in feedstuff；
Matched group 1 adds the Fuzheng Jiedu medicine by pharmacopeia 2010 editions preparation in feedstuff.
Mixed feeding in the quantity set of 1g is all given every day by every chicken；Respective continuous use 3 days, stops observation post administration 1 week.
Curative effect judging standard
Curing: after test chicken administration, lassitude, diarrhoea, row be faint yellow or the clinical symptoms such as linen not sample loose stool, dehydration all disappears；And spirit, appetite, feces, breathing etc. recover normal for curing.
Effective: all during testing, after chicken medication, the spirit of test chicken, appetite, breathing are clearly better as effectively.
Invalid: during test, there is the classical symptom of infectious bursal disease and dead in test chicken, after necropsy, visible chest muscle, lower limb flesh, glandular stomach, kidney and bursal disease etc. have typical feature disease to become, and all can determine that as infecting death or symptom does not alleviate or continues to worsen as invalid.
Experimental result is as shown in the table:
Experimental group increases the case of dysentery, symptom of having loose bowels newly.The Fuzheng Jiedu medicine of present invention effect in treatment chicken bursal disease is not second to existing powder effect as can be seen here.And add Radix Et Rhizoma Rhei also without the side effect such as cause that chicken has loose bowels.
2. refrigeration function effect
Choose that Hechuan large-scale hoggery feeding and management condition is essentially identical, age in days is close in birth, swine fever or swine influenza heating, body temperature, 39.0 ± 5 DEG C of cases 57, is randomly divided into 3 groups, often group 19.
Experimental group one: the ratio adding the Fuzheng Jiedu medicine 1g that embodiment 6 prepares in per kilogram of body weight every day in feedstuff feeds, disposable feeds intake；
Experimental group one: the ratio adding the Fuzheng Jiedu medicine 1g that embodiment 7 prepares in per kilogram of body weight every day in feedstuff feeds, disposable feeds intake；
Matched group one: add 5g10% tilmicosin pre-mixing agent, 1g in feedstuff by the Fuzheng Jiedu medicine of pharmacopeia 2010 editions preparation by per kilogram of body weight every day, disposable feed intake；
Matched group two: add the 1g Fuzheng Jiedu medicine by pharmacopeia 2010 editions preparation in feedstuff by per kilogram of body weight every day, disposable feed intake.
Other conditions such as each group uses 3 days all continuously, feeding and management are identical.Then within 2 hours, 24 hours, 48 hours, 72 hours, 144 hours after first time feeds, measuring anus temperature, record data, result is shown in following table:
Swine fever or the antipyretic result of the test of swine influenza fever patients (DEG C, ± S)
It can be seen that after 2 hours, use the temperature of pig body of medicine of the present invention to be decreased obviously, within 24 hours, return to normal level.The test group using tilmicosin pre-mixing agent and existing Fuzheng Jiedu medicine shows the performance suitable with medicine of the present invention.Existing Fuzheng Jiedu medicine is used merely then sick temperature of pig body substantially not to be treated and improves effect.The sick body of two test group can refresh state and appetite substantially in 24 hours, it is not necessary to uses other antibiotic or antiviral drugs to fully recover voluntarily.Advantageously promote animal recover more afterwards and grow.Reduce antibiotic usage.And experimental group 1,2 is also without newly-increased dysentery case.The sick body of matched group two is required for using antibiotic therapy to fully recover, and has an example Relapse rate dead.
Additionally to 1355 chickens of chicken house, by once a day in feedstuff, the prevention consumption of each per kilogram of body weight 0.5g feeds；Matched group 1200 is only without medicine, when other condition is identical.The infectious bursal disease morbidity example of experimental group chicken is 5.02%, and matched group is 31%.Same scale of feeding is when other condition is identical, and experimental group swine influenza sickness rate is 1.62%, and matched group is 23%.Also without the phenomenon that appearance is suffered from diarrhoea because of medication, drawn tripe symptom to increase, it is seen that the medicine of the present invention can regulate animal body immunity, strengthen anti-virus ability.
Claims (3)
1. a poultry Fuzheng Jiedu superfine powder, it is characterised in that: it is made up of the raw material of following parts by weight: Radix Isatidis 60 parts, the Radix Astragali 60 parts, Herba Epimedii 30 parts, Radix Et Rhizoma Rhei 10～16 parts, tetramethylolmethane superfine powder 13～17 parts.
2. a kind of poultry Fuzheng Jiedu superfine powder according to claim 1, it is characterised in that: described Radix Et Rhizoma Rhei 13 parts.
3. a kind of poultry Fuzheng Jiedu superfine powder according to claim 1, it is characterised in that: described tetramethylolmethane superfine powder 16 parts.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110051735A (en) * | 2019-04-30 | 2019-07-26 | 河北维尔利动物药业集团有限公司 | Livestock and poultry Fuzheng Jiedu broken wall superfine powder and its preparation process |
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| CN101342231A (en) * | 2008-08-15 | 2009-01-14 | 张秀英 | Ultramicro powder formulation of strengthen the body resistance detoxication powder and preparation method thereof |
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| CN110051735A (en) * | 2019-04-30 | 2019-07-26 | 河北维尔利动物药业集团有限公司 | Livestock and poultry Fuzheng Jiedu broken wall superfine powder and its preparation process |
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Application publication date: 20160706 |