CN101850008A - Bacillus Ling oral liquid and preparation method thereof - Google Patents
Bacillus Ling oral liquid and preparation method thereof Download PDFInfo
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- CN101850008A CN101850008A CN 201010195028 CN201010195028A CN101850008A CN 101850008 A CN101850008 A CN 101850008A CN 201010195028 CN201010195028 CN 201010195028 CN 201010195028 A CN201010195028 A CN 201010195028A CN 101850008 A CN101850008 A CN 101850008A
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Abstract
The invention discloses a bacillus Ling oral liquid and a preparation method thereof. The bacillus Ling oral liquid is mainly prepared from the following raw material components by weight parts: 250-450 parts of rhizoma coptidis, 500-700 parts of baikal skullcap roots, 300-500 parts of gardenia, 200-400 parts of common andrographis herb, 150-300 parts of roots of Chinese pulsatilla and 50-200 parts of liquorice. The preparation method comprises the steps of: mixing the six medicines in uniformity, adding water and decocting for two times; filtering; maintaining the temperature at 55-65 DEG C; decompressing and concentrating into extractum with a relative density of 1.05-1.20g/ml; adding a proper amount of auxiliary materials and 25-40% of sucrose, and stirring in uniformity; adding water to be in 800-2000 parts; settling for 24 hours; adding enough water to be in the original part; and bottling to obtain the bacillus Ling oral liquid. The bacillus Ling oral liquid has the advantages of simple process control, high bioavailability, good effect, high efficacy and low cost.
Description
Technical field
The present invention relates to treat the colibacillosis drug world, be specially bacillus Ling oral liquid that is used for the treatment of the animal large intestine bacillosis and preparation method thereof.
Background technology
Colibacillosis is that what to be caused by bacillus coli (E.Coil)～I is a kind of bacterial infectious disease of feature to face multiple symptoms such as disease performance acute sepsis, yolk peritonitis, arthritis, pericarditis.Risen at present one of the most thorny disease of harm aviculture, colibacillosis mainly takes vaccine immunization, antibacterials and Chinese herbal medicine to prevent and treat.Wherein vaccine immunization is because of its serotype, enteric microorganism antigen and antigenic determinant complexity, and immunologic mechanism there are differences, and prevents and treats this disease from the vaccine angle and does not make a breakthrough as yet, and immune effect is often imprecise.Therefore antibacterials are still the main means of this disease of control.And medication and uncontrolled prolongation administration time are added in the prevention of the abuse of antimicrobial drug and a large amount of inferior therapeutic doses, feedstuff, have all caused the chemical sproof generation of escherichia coli, propagation, caused drug residue simultaneously and endanger human and livestock health and sanitarian may
[1]The continuous appearance of drug resistance strain, many antibacterials after continuous application 2～3 years just curative effect descend, and have that toxicity is big, cost is high, characteristics such as drug residue arranged.Therefore, it is strong, residual and toxicity is low, poultry be difficult for is produced chemical sproof Chinese herbal medicine is the demand in market to seek a kind of antibacterial action.
By the dialectical theory of Chinese veterinarian, colibacillosis is the interior-heat disease that the long-pending intestinal of damp and hot heap soil or fertilizer over and around the roots causes, a surname's heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping.China's tradition Chinese herbal medicine is the natural antibacterial agent of using under traditional Chinese medicine theory instructs, many experiences have been accumulated aspect the bacterial disease preventing and treating, monarch cooperates, coordinate mutually to using, the effect for the treatment of both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors can be reached, and drug resistance and drug residue that the antibiotic abuse causes can be effectively reduced.
Rhizoma Coptidis in the Chinese herbal medicine is rushed down inflammation, detoxifcation, heat clearing away, dampness, has effects such as antibiotic, virus and protozoon, function of gallbladder promoting, is used for diseases such as damp-heat dysentery, conjunctival congestion toxic swelling; Radix Scutellariae heat clearing away, dampness, detoxifcation, hemostasis have the effect of antibiotic, calm analgesic, antiinflammatory and immunity, diseases such as the excessive thirst that is used to generate heat, cough due to lung-heat, dysentery pyretic stranguria, jaundice due to damp-heat, carbuncle sore tumefacting virus; Fructus Gardeniae pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis have hepatic cholagogic, anti-fiery analgesic effect, are used for diseases such as calentura is vexed, conjunctival congestion, jaundice, pathopyretic ulcer; Herba Andrographis heat clearing away, antiinflammatory, detoxifcation have effects such as analgesic, antiinflammatory, resisting pathogenic microbes, are used for anemopyretic cold, enteritis, dysentery, snake venom disease such as bite; Radix Pulsatillae heat-clearing and toxic substances removing, antidiarrheal dysentery relieving have anti-Ah rice and fawn on protozoon, antitumor, effect such as antibiotic, are used for diseases such as bacillary dysentery, amebic dysentery; Effects such as Radix Glycyrrhizae invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, heat-clearing and toxic substances removing, the mediation property of medicine, but the property of medicine of coordinating the actions of various ingredients in a prescription can be gathered the effect of eliminating fire and detoxication better altogether to reach all medicines.
Summary of the invention
Technical problem solved by the invention is to provide a kind of bacillus Ling oral liquid for the treatment of the animal large intestine bacillosis and preparation method thereof, to solve the shortcoming in the above-mentioned background technology.
Technical problem solved by the invention realizes by the following technical solutions:
1, the main component of bacillus Ling oral liquid is formed, and counts by weight, and raw material is composed as follows: Rhizoma Coptidis 250-450 part, Radix Scutellariae 500-700 part, Fructus Gardeniae 300-500 part, Herba Andrographis 200-400 part, Radix Pulsatillae 150-300 part, Radix Glycyrrhizae 50-200 part.
Rhizoma Coptidis is rushed down inflammation, detoxifcation, heat clearing away, dampness, has effects such as antibiotic, virus and protozoon, function of gallbladder promoting, is used for diseases such as damp-heat dysentery, conjunctival congestion toxic swelling; Radix Scutellariae heat clearing away, dampness, detoxifcation, hemostasis have the effect of antibiotic, calm analgesic, antiinflammatory and immunity, diseases such as the excessive thirst that is used to generate heat, cough due to lung-heat, dysentery pyretic stranguria, jaundice due to damp-heat, carbuncle sore tumefacting virus; Fructus Gardeniae pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis have hepatic cholagogic, anti-fiery analgesic effect, are used for diseases such as calentura is vexed, conjunctival congestion, jaundice, pathopyretic ulcer; Herba Andrographis heat clearing away, antiinflammatory, detoxifcation have effects such as analgesic, antiinflammatory, resisting pathogenic microbes, are used for anemopyretic cold, enteritis, dysentery, snake venom disease such as bite; Radix Pulsatillae heat-clearing and toxic substances removing, antidiarrheal dysentery relieving have anti-Ah rice and fawn on protozoon, antitumor, effect such as antibiotic, are used for diseases such as bacillary dysentery, amebic dysentery; Effects such as Radix Glycyrrhizae invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, heat-clearing and toxic substances removing, the mediation property of medicine.
2, and by following processing step and technological parameter prepare:
With Rhizoma Coptidis 250-450 part, Radix Scutellariae 500-700 part, Fructus Gardeniae 300-500 part, Herba Andrographis 200-400 part, Radix Pulsatillae 150-300 part, Radix Glycyrrhizae 50-200 part; 6 flavor medicine mix homogeneously, decoct with water twice, collecting decoction filters, temperature keeps 55-65 ℃ and is evaporated to the extractum that relative density is 1.05～1.20g/ml, add appropriate amount of auxiliary materials and 25-40% sucrose, stir, add water to 800-2000 part, left standstill 24 hours, supply water to original umber, fill, promptly.
In the present invention, the optimum weight proportioning is as follows: 300 parts of Rhizoma Coptidis, 600 parts of Radix Scutellariaes, 450 parts of Fructus Gardeniaes, 250 parts of Herba Andrographis, 250 parts of the Radix Pulsatillaes, 100 parts in Radix Glycyrrhizae; 60 ℃ of best thickening temperatures, best extractum relative density is 1.10g/ml, and best sucrose ratio is 30%, and best amount of water is 1000 parts.
The present invention is a dark-brown liquid; Sweet in the mouth, hardship, eliminating fire and detoxication cures mainly poultry diarrhoea, septicemia, airsacculitis, enteritis and pig Huang that coli-infection causes, Hakuri etc., and the every premium on currency 1.0～1.5ml of pig mixes drink, and the every premium on currency 1.5-2.5ml of fowl mixes drink.
Authentication method of the present invention has 2 kinds, and is as follows:
(1) get this product 10ml, put to steam in the water-bath near and do, add methanol 20ml, reflux 15 minutes filters, and evaporate to dryness in the filtrate water-bath, residue add ethanol 5ml dissolving, as need testing solution.Other gets Rhizoma Coptidis control medicinal material 0.5g, adds methanol 10ml, and reflux 15 minutes filters, and filtrate is medical material solution in contrast.Get the berberine hydrochloride reference substance again, add methanol and make the solution that every 1ml contains 0.5mg, in contrast product solution.Test according to thin layer chromatography, draw each 5 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with benzene-ethyl acetate-isopropyl alcohol-strong ammonia solution (6: 3: 15: be developing solvent 0.5), put in the chromatography cylinder of ammonia saturated with vapor, launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect, with the corresponding position of control medicinal material chromatograph on, show identical yellow fluorescence speckle; With the corresponding position of reference substance chromatograph on, show an identical yellow fluorescence speckle.
(2) get this product 10ml, put to steam in the water-bath near and do, add methanol 20ml, supersound process 20 minutes filters, and filtrate evaporate to dryness, residue add methanol 5ml makes dissolving, as need testing solution.Other gets Radix Scutellariae control medicinal material 1g, shines medical material solution in pairs with legal system.Get the baicalin reference substance again, add methanol and make the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography, draw each 5 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the carboxymethylcellulose sodium solution that contains 4% sodium acetate, with ethyl acetate-butanone-formic acid-water (5: 3: 1: 1) be developing solvent, pre-equilibration 30 minutes launches, and takes out, dry, spray is with 1% ferric chloride alcoholic solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color; With the corresponding position of reference substance chromatograph on, show an identical dirty-green speckle.
Clinical test results of the present invention is as follows:
(1) healthy chicken of random choose 30 ages in days is 180, average weight 0.85kg, be divided into 6 groups at random, comprise small dose group (1.5ml/L drinking water), middle dosage group (2.0ml/L drinking water), heavy dose of group (2.5ml/L drinking water), the routine administration group, positive controls, negative control group, every group 30, and adjust that respectively to organize body weight basic identical; Remove negative control group, all the other 5 groups through thoracic cavity injection escherichia coli suspension 0.8ml (6 * 108 bacterium/ml), the bacillus Ling oral liquid of choosing the present invention's preparation is for being subjected to the reagent thing, and selection control drug enrofloxacin solution (dosage is the 2.5g/L drinking water), 6 hours medication groups liquid medicine that contains of regulation that begins to feed behind the counteracting toxic substances, successive administration 7 days infected the back the 8th day, the Total Test chicken is single only weighs, and calculates and respectively organizes rate of body weight gain.Observe during the administration, write down and respectively organize clinical manifestation, and judge clinical efficacy according to healing, effective, invalid diagnostic criteria.Design experiment, route of administration and therapeutic dose are made table 1.
Table 1
(2) observe clinical manifestation, duration of test is observed and is write down spirit, appetite and the feces of respectively organizing test chicken and discharges situation; Calculate rate of body weight gain: when on-test (average weight after the off-test-average weight) ÷ average weight * 100% during on-test, the relative weight gain rate: medication group or the rate of body weight gain ÷ that infects not medication group do not infect rate of body weight gain * 100% of not medication group; To healing, effective, the invalid statistical analysis that carries out, cure: sick fowl through the Drug therapy clinical symptoms as spirit, appetite, feces etc. normally and healthy chicken symptom indifference in experimental period, effectively: sick fowl all takes a turn for the better as spirit, appetite, feces to some extent through the Drug therapy clinical symptoms in experimental period, invalid: in experimental period sick fowl through the Drug therapy clinical symptoms as spirit, appetite, feces no change, and have the reconstructed image of adding to occur resembling to occur as invalid; Data statistic analysis: the difference of comparing each medication group and positive controls with X 2 test; The relatively difference of large, medium and small dosage group of bacillus Ling oral liquid and routine administration group.
Analysis result is made the influence table 2 of bacillus Ling oral liquid to the chicken growth.
Table 2
△ △ compares with positive controls, and utmost point significant difference (P＜0.01) is arranged
*Compare with the routine administration group, significant difference (P＜0.05) is arranged
As seen from the experiment, the initial average weight of each test group is about 850g, and each administration group the relative weight gain rate of test back is at 64.5-81.4%, and the face positive controls loses weight, and the relative weight gain rate is-10.6%.Each administration group treatment effective percentage has utmost point significant difference (P＜0.01) greater than positive controls; The large, medium and small dosage group clinical effectiveness of bacillus spirit is remarkable, and each organizes effective percentage greater than 93.3%, and wherein heavy dose of group curative effect is better than routine administration matched group (P＜0.05).Show by clinical trial; the compound Chinese medicinal preparation bacillus Ling oral liquid can effectively reduce the chicken death rate that causes because of escherichia coli; alleviate its various symptoms that rise because of ehec infection and the degree of pathological changes, appetite and the spirit of protection chicken are quickened the process of its rehabilitation.Test shows that it has good curative effect to the sick chicken that escherichia coli cause, compares with control drug, is better than similar medicine enrofloxacin.
Beneficial effect:
The bacillus Ling oral liquid technology controlling and process that the present invention makes is simple, the bioavailability height, and good drug efficacy, curative effect is fast, and cost is low.
The specific embodiment
Best embodiment of the present invention divides other scheme according to integral body, implements respectively, below by embodiment the present invention is specifically described:
Embodiment 1:
1. the key component of bacillus Ling oral liquid is formed, and counts by weight, and raw material is composed as follows: 250 parts of Rhizoma Coptidis, 650 parts of Radix Scutellariaes, 400 parts of Fructus Gardeniaes, 200 parts of Herba Andrographis, 200 parts of the Radix Pulsatillaes, 150 parts in Radix Glycyrrhizae;
2. and by following processing step and technological parameter prepare:
With 250 parts of Rhizoma Coptidis, 650 parts of Radix Scutellariaes, 400 parts of Fructus Gardeniaes, 200 parts of Herba Andrographis, 200 parts of the Radix Pulsatillaes, 150 parts in Radix Glycyrrhizae, 6 flavor medicine mix homogeneously decoct with water twice, collecting decoction, filter, temperature keeps 65 ℃ and is evaporated to the extractum that relative density is 1.15g/ml, adds appropriate amount of auxiliary materials and 40% sucrose, stir, add water to 800-2000 part, left standstill 24 hours, supply water to original umber, fill, promptly.
The bacillus Ling oral liquid of producing is mixed drinking water, 30 of the chickling of raising trouble colibacillosis, every 1L water adds the 1.5ml bacillus Ling oral liquid, raises 27 chickling recoveries from illness 8 days.
Embodiment 2:
1. the key component of bacillus Ling oral liquid is formed, and counts by weight, and raw material is composed as follows: 300 parts of Rhizoma Coptidis, 600 parts of Radix Scutellariaes, 450 parts of Fructus Gardeniaes, 250 parts of Herba Andrographis, 250 parts of the Radix Pulsatillaes, 100 parts in Radix Glycyrrhizae;
2. and by following processing step and technological parameter prepare:
With 300 parts of Rhizoma Coptidis, 600 parts of Radix Scutellariaes, 450 parts of Fructus Gardeniaes, 250 parts of Herba Andrographis, 250 parts of the Radix Pulsatillaes, 100 parts in Radix Glycyrrhizae, 6 flavor medicine mix homogeneously decoct with water twice, collecting decoction, filter, temperature keeps 60 ℃ and is evaporated to the extractum that relative density is 1.10g/ml, adds appropriate amount of auxiliary materials and 30% sucrose, stir, add water to 1000 parts, left standstill 24 hours, supply water to original umber, fill, promptly.
The bacillus Ling oral liquid of producing is mixed drinking water, 30 of the young rabbits of raising trouble colibacillosis, every 1L water adds the 1.5ml bacillus Ling oral liquid, raises 29 young rabbits recoveries from illness 8 days.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in the foregoing description and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (7)
1. bacillus Ling oral liquid is characterized in that, its main component is formed, and counts by weight, raw material is composed as follows: Rhizoma Coptidis 250-450 part, Radix Scutellariae 500-700 part, Fructus Gardeniae 300-500 part, Herba Andrographis 200-400 part, Radix Pulsatillae 150-300 part, Radix Glycyrrhizae 50-200 part.
2. bacillus Ling oral liquid according to claim 1 is characterized in that, the optimum weight proportioning is as follows: 300 parts of Rhizoma Coptidis, 600 parts of Radix Scutellariaes, 450 parts of Fructus Gardeniaes, 250 parts of Herba Andrographis, 250 parts of the Radix Pulsatillaes, 100 parts in Radix Glycyrrhizae.
3. the bacillus Ling oral liquid preparation method is characterized in that, and prepares by following processing step and technological parameter:
With Rhizoma Coptidis 250-450 part, Radix Scutellariae 500-700 part, Fructus Gardeniae 300-500 part, Herba Andrographis 200-400 part, Radix Pulsatillae 150-300 part, Radix Glycyrrhizae 50-200 part; 6 flavor medicine mix homogeneously, decoct with water twice, collecting decoction filters, temperature keeps 55-65 ℃ and is evaporated to the extractum that relative density is 1.05～1.20g/ml, add appropriate amount of auxiliary materials and 25-40% sucrose, stir, add water to 800-2000 part, left standstill 24 hours, supply water to original umber, fill, promptly.
4. bacillus Ling oral liquid preparation method according to claim 3 is characterized in that, 60 ℃ of best thickening temperatures.
5. bacillus Ling oral liquid preparation method according to claim 3 is characterized in that, best extractum relative density is 1.10g/ml.
6. bacillus Ling oral liquid preparation method according to claim 3 is characterized in that, best sucrose ratio is 30%.
7. bacillus Ling oral liquid preparation method according to claim 3 is characterized in that, best amount of water is 1000 parts.
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397366A (en) * | 2011-11-16 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis pure Chinese medicinal composition for treating fowl cholera and preparation method thereof |
| CN102552502A (en) * | 2012-01-11 | 2012-07-11 | 河南天纳图生物科技有限公司 | Traditional Chinese medicine for treating bacterial diseases in poultry |
| CN102670762A (en) * | 2012-05-23 | 2012-09-19 | 天津生机集团股份有限公司 | Chinese medicinal composition for treating drug-resistant Salmonellosis avium, and preparation method thereof |
| CN103356775A (en) * | 2013-07-08 | 2013-10-23 | 江西中成药业集团有限公司 | Coptis chinensis-scutellaria baicalensis-cape jasmine oral liquid for livestock and preparation method thereof |
| CN103690771A (en) * | 2013-12-25 | 2014-04-02 | 山东新希望六和集团有限公司 | Drug for treating colibacillosis in lambs and preparation method of drug |
| CN103784858A (en) * | 2012-11-01 | 2014-05-14 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition for treating escherichia coli disease of poultry |
| CN106421305A (en) * | 2016-09-30 | 2017-02-22 | 安徽华澳生物技术有限公司 | Medicament for preventing and controlling avian airsacculitis |
| CN106417972A (en) * | 2016-09-30 | 2017-02-22 | 安徽华澳生物技术有限公司 | Feed capable of preventing chicken air sacculitis |
| CN107137640A (en) * | 2017-06-30 | 2017-09-08 | 张可池 | Prevent and treat traditional Chinese medicine oral liquid of pet porkling virus diarrhea and preparation method thereof |
| CN110787247A (en) * | 2019-11-19 | 2020-02-14 | 大连三仪动物药品有限公司 | Traditional Chinese medicine microecological preparation for preventing and treating livestock and poultry diarrhea and preparation method thereof |
| CN111481500A (en) * | 2020-04-17 | 2020-08-04 | 洛阳朗威动物药业有限公司 | Formula and preparation process of gardenia jasminoides oral liquid with blood cooling and dysentery stopping effects |
| CN115919942A (en) * | 2022-11-03 | 2023-04-07 | 河北农业大学 | Compound prescription of compound Chinese herbal medicine and lactobacillus and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601756A (en) * | 2009-07-23 | 2009-12-16 | 天津生机集团股份有限公司 | Chinese medicine composition of treatment chicken colibacillosis and preparation method thereof |
-
2010
- 2010-06-08 CN CN 201010195028 patent/CN101850008A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601756A (en) * | 2009-07-23 | 2009-12-16 | 天津生机集团股份有限公司 | Chinese medicine composition of treatment chicken colibacillosis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 《中国农业信息网 网址：http://www.agri.gov.cn/webV05/topics/nongshouyuyao/yangzhiwu/zhuxinwen/201005/t20100526_1539655.htm 》 20100526 不详 杆菌灵口服液配方 处方及制法 1-7 , 2 * |
| 《猪病120网 网址：http://www.zhubing120.com/2010/0310/999.html 》 20100330 hns 杆菌灵口服液配方 处方及制法 1-7 , 2 * |
| 《阳光畜牧网 网址：http://www.ygsite.cn/show.asp?id=6158》 20100227 不详 杆菌灵口服液配方 处方及制法 1-7 , 2 * |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397366A (en) * | 2011-11-16 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis pure Chinese medicinal composition for treating fowl cholera and preparation method thereof |
| CN102552502A (en) * | 2012-01-11 | 2012-07-11 | 河南天纳图生物科技有限公司 | Traditional Chinese medicine for treating bacterial diseases in poultry |
| CN102670762B (en) * | 2012-05-23 | 2017-09-29 | 天津生机集团股份有限公司 | Chinese medicine composition for treating fowl drug resistance salmonellosis and preparation method thereof |
| CN102670762A (en) * | 2012-05-23 | 2012-09-19 | 天津生机集团股份有限公司 | Chinese medicinal composition for treating drug-resistant Salmonellosis avium, and preparation method thereof |
| CN103784858A (en) * | 2012-11-01 | 2014-05-14 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition for treating escherichia coli disease of poultry |
| CN103356775A (en) * | 2013-07-08 | 2013-10-23 | 江西中成药业集团有限公司 | Coptis chinensis-scutellaria baicalensis-cape jasmine oral liquid for livestock and preparation method thereof |
| CN103356775B (en) * | 2013-07-08 | 2015-02-18 | 江西中成药业集团有限公司 | Coptis chinensis-scutellaria baicalensis-cape jasmine oral liquid for livestock and preparation method thereof |
| CN103690771A (en) * | 2013-12-25 | 2014-04-02 | 山东新希望六和集团有限公司 | Drug for treating colibacillosis in lambs and preparation method of drug |
| CN103690771B (en) * | 2013-12-25 | 2015-11-04 | 山东新希望六和集团有限公司 | Be used for the treatment of medicine of lamb colibacillosis and preparation method thereof |
| CN106421305A (en) * | 2016-09-30 | 2017-02-22 | 安徽华澳生物技术有限公司 | Medicament for preventing and controlling avian airsacculitis |
| CN106417972A (en) * | 2016-09-30 | 2017-02-22 | 安徽华澳生物技术有限公司 | Feed capable of preventing chicken air sacculitis |
| CN107137640A (en) * | 2017-06-30 | 2017-09-08 | 张可池 | Prevent and treat traditional Chinese medicine oral liquid of pet porkling virus diarrhea and preparation method thereof |
| CN110787247A (en) * | 2019-11-19 | 2020-02-14 | 大连三仪动物药品有限公司 | Traditional Chinese medicine microecological preparation for preventing and treating livestock and poultry diarrhea and preparation method thereof |
| CN110787247B (en) * | 2019-11-19 | 2021-06-01 | 大连三仪动物药品有限公司 | Traditional Chinese medicine microecological preparation for preventing and treating livestock and poultry diarrhea and preparation method thereof |
| CN111481500A (en) * | 2020-04-17 | 2020-08-04 | 洛阳朗威动物药业有限公司 | Formula and preparation process of gardenia jasminoides oral liquid with blood cooling and dysentery stopping effects |
| CN115919942A (en) * | 2022-11-03 | 2023-04-07 | 河北农业大学 | Compound prescription of compound Chinese herbal medicine and lactobacillus and application |
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