CN111481500A - Formula and preparation process of gardenia jasminoides oral liquid with blood cooling and dysentery stopping effects - Google Patents
Formula and preparation process of gardenia jasminoides oral liquid with blood cooling and dysentery stopping effects Download PDFInfo
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Abstract
The invention discloses a formula of a gardenia jasminoides oral liquid with effects of cooling blood and stopping dysentery and a preparation process thereof, and relates to the technical field of veterinary drugs, wherein the gardenia jasminoides oral liquid comprises the following medicinal components: coptis chinensis, scutellaria baicalensis, gardenia, common andrographis herb, Chinese pulsatilla root, liquorice and purified water; the traditional Chinese medicine composition has good effects of clearing heat and removing toxicity, cooling blood and stopping dysentery, and soothing nerves and relieving pain, has no toxic or side effect, does not generate medicine residues, meets the requirements of safe veterinary medicines and animal-derived food safety, and is low in cost.
Description
Technical Field
The invention relates to the technical field of veterinary medicines, and particularly relates to a formula of a gardenia jasminoides oral liquid with effects of cooling blood and stopping dysentery and a preparation process thereof.
Background
China is a big livestock and poultry breeding country, and research and development work of medicines for treating livestock and poultry diseases is not stopped all the time. In the face of better market trend, the requirements of countries in the world on edible safety are higher and higher, along with the progress of scientific technology, more and more medicine residues are detected and proved to be harmful to human health, the supervision of medicine residue problems is increased in the countries in the world, and the method also generates not less impact on livestock and poultry breeding in China and provides a problem which needs to be solved urgently. The green and healthy traditional Chinese medicine products are more and more valued by the majority of veterinary drug production enterprises, are loved by breeding users and are popular with consumers.
Diarrhea is a common symptom after livestock eats and is manifested in various ways and caused by multiple reasons. Serious and continuous abdomen often causes digestive dysfunction, so that the body is in general malnutrition, emaciation and even death, and the breeding benefit is greatly influenced. With the development of intensive culture, epidemic diseases are more prevalent. The mass diarrhea caused by various virus and bacterial infections or mixed infections is frequent, and the young livestock and poultry are more susceptible than the adult livestock and poultry, wherein the incidence rate of early weaned piglet diarrhea is the highest and can reach about 30 percent. Although many drugs are available on the market for symptomatic treatment of diarrhea, almost all antibiotics or drugs to which antibiotics are added develop resistance due to abuse of antibiotics. Therefore, the drug which is not easy to generate drug resistance and has good drug effect and spectrum for treating the diarrhea of the livestock and poultry is urgently needed by the market.
Disclosure of Invention
The invention aims to: in order to solve the technical problems, the invention provides a formula of a gardenia jasminoides oral liquid with the effects of cooling blood and stopping dysentery and a preparation process thereof.
The invention specifically adopts the following technical scheme for realizing the purpose:
a formula of an oral liquid of cape jasmine for cooling blood and stopping dysentery comprises the following medicinal components: coptis root, scutellaria baicalensis, gardenia, common andrographis herb, Chinese pulsatilla root, liquorice and purified water.
Further, the formula of the gardenia jasminoides oral liquid with the effects of cooling blood and stopping dysentery comprises the following medicinal components in parts by mass: 200 to 350g of coptis root, 450 to 750g of scutellaria root, 400 to 650g of gardenia, 200 to 350g of common andrographis herb, 200 to 350g of Chinese pulsatilla root, 100 to 250g of liquorice and purified water.
Further, the formula of the gardenia jasminoides oral liquid with the effects of cooling blood and stopping dysentery comprises the following medicinal materials in parts by mass: 350g of coptis root, 750g of scutellaria root, 650g of cape jasmine fruit, 350g of andrographis paniculata, 350g of Chinese pulsatilla root, 250g of liquorice and purified water.
Further, the formula of the gardenia jasminoides oral liquid with the effects of cooling blood and stopping dysentery comprises the following medicinal materials in parts by mass: 200g of coptis chinensis, 450g of scutellaria baicalensis, 400g of cape jasmine, 200g of andrographis paniculata, 200g of Chinese pulsatilla root, 100g of liquorice and purified water.
A preparation process of a formula of a gardenia jasminoides oral liquid with effects of cooling blood and stopping dysentery comprises the following steps:
step 1, weighing 200-350 g of coptis chinensis, 450-750 g of scutellaria baicalensis, 400-650 g of gardenia, 200-350 g of andrographis paniculata, 200-350 g of Chinese pulsatilla root and 100-250 g of liquorice, adding water into the six medicinal materials of the coptis chinensis, the scutellaria baicalensis, the gardenia, the andrographis paniculata, the Chinese pulsatilla root and the liquorice, decocting the two medicinal materials twice, and combining and decocting the two medicinal materials to obtain basic liquid medicine;
step 2, filtering the basic liquid medicine obtained in the step 1 to obtain filtrate, and then concentrating the filtrate into clear paste with the relative density of 1.10 at the temperature of 55 ℃;
step 3, adding 50-100 ml of 25% sucrose into the clear paste obtained in the step 2, uniformly stirring, and then adding water to 1000 ml;
and 4, standing for 24 hours, filtering, adding water to 1000ml, and filling to obtain the gardenia jasminoides oral liquid.
The preparation process of the formula of the gardenia jasminoides oral liquid with the effect of cooling blood and stopping dysentery according to claim 2, wherein in the step 2, the stirring speed is 50 times/min.
The invention has the following beneficial effects:
1. the invention is mainly used for treating damp-heat diarrhea and dark brown liquid; the traditional Chinese medicine composition has sweet and bitter taste, has the effects of clearing heat and detoxicating, cooling blood and stopping dysentery, is sealed, is placed in a shady and cool place, has good effects of clearing heat and detoxicating, cooling blood and stopping dysentery, soothing nerves and relieving pain, has no toxic or side effect, does not generate medicine residues, meets the requirements of safe veterinary medicines and guaranteeing the safety of animal-derived foods, has low cost, is convenient to use, contains the natural traditional Chinese medicine components of the coptis chinensis, the scutellaria baicalensis, the gardenia, the andrographis paniculata, the Chinese pulsatilla root and the liquorice, can effectively treat the common symptoms of damp-heat diarrhea, bloody pus and the like of.
2. The traditional Chinese medicine composition has good effects of clearing heat and removing toxicity, cooling blood and stopping dysentery, and soothing nerves and relieving pain, has no toxic or side effect, does not generate medicine residues, meets the requirements of safe veterinary medicines and animal-derived food safety, and is low in cost, convenient to use and simple in preparation method.
Detailed Description
The following examples further describe the invention in detail in order that those skilled in the art may better understand the invention.
Example 1
A preparation process of a formula of a gardenia jasminoides oral liquid with effects of cooling blood and stopping dysentery comprises the following steps:
step 1, weighing 200g of coptis chinensis, 450g of scutellaria baicalensis, 400g of gardenia, 200g of andrographis paniculata, 200g of Chinese pulsatilla root and 100g of liquorice, decocting six medicinal materials of the coptis chinensis, the scutellaria baicalensis, the gardenia, the andrographis paniculata, the Chinese pulsatilla root and the liquorice in water twice, and mixing and decocting to obtain a basic liquid medicine;
step 2, filtering the basic liquid medicine obtained in the step 1 to obtain filtrate, and then concentrating the filtrate into clear paste with the relative density of 1.10 at the temperature of 55 ℃;
step 3, adding 50-100 ml of 25% sucrose into the clear paste obtained in the step 2, uniformly stirring at the stirring speed of 50 times/min, and then adding water to 1000 ml;
and 4, standing for 24 hours, filtering, adding water to 1000ml, and filling to obtain the gardenia jasminoides oral liquid.
Example 2
A preparation process of a formula of a gardenia jasminoides oral liquid with effects of cooling blood and stopping dysentery comprises the following steps:
step 1, weighing 350g of coptis chinensis, 750g of scutellaria baicalensis, 650g of gardenia, 350g of andrographis paniculata, 350g of Chinese pulsatilla root and 250g of liquorice, decocting six medicinal materials of the coptis chinensis, the scutellaria baicalensis, the gardenia, the andrographis paniculata, the Chinese pulsatilla root and the liquorice in water twice, and mixing and decocting to obtain a basic liquid medicine;
step 2, filtering the basic liquid medicine obtained in the step 1 to obtain filtrate, and then concentrating the filtrate into clear paste with the relative density of 1.10 at the temperature of 55 ℃;
step 3, adding 50-100 ml of 25% sucrose into the clear paste obtained in the step 2, uniformly stirring at the stirring speed of 50 times/min, and then adding water to 1000 ml;
and 4, standing for 24 hours, filtering, adding water to 1000ml, and filling to obtain the gardenia jasminoides oral liquid.
Example 3
A preparation process of a formula of a gardenia jasminoides oral liquid with effects of cooling blood and stopping dysentery comprises the following steps:
step 1, weighing 250g of coptis chinensis, 600g of scutellaria baicalensis, 500g of gardenia, 250g of andrographis paniculata, 300g of Chinese pulsatilla root and 180g of liquorice, decocting the six medicinal materials of the coptis chinensis, the scutellaria baicalensis, the gardenia, the andrographis paniculata, the Chinese pulsatilla root and the liquorice with water twice, and mixing and decocting to obtain a basic liquid medicine;
step 2, filtering the basic liquid medicine obtained in the step 1 to obtain filtrate, and then concentrating the filtrate into clear paste with the relative density of 1.10 at the temperature of 55 ℃;
step 3, adding 50-100 ml of 25% sucrose into the clear paste obtained in the step 2, uniformly stirring at the stirring speed of 50 times/min, and then adding water to 1000 ml;
and 4, standing for 24 hours, filtering, adding water to 1000ml, and filling to obtain the gardenia jasminoides oral liquid.
Example 4
A preparation process of a formula of a gardenia jasminoides oral liquid with effects of cooling blood and stopping dysentery comprises the following steps:
step 1, weighing 300g of coptis chinensis, 600g of scutellaria baicalensis, 580g of gardenia, 320g of andrographis paniculata, 290g of Chinese pulsatilla root and 230g of liquorice, decocting six medicinal materials of the coptis chinensis, the scutellaria baicalensis, the gardenia, the andrographis paniculata, the Chinese pulsatilla root and the liquorice in water twice, and mixing and decocting to obtain basic liquid medicine;
step 2, filtering the basic liquid medicine obtained in the step 1 to obtain filtrate, and then concentrating the filtrate into clear paste with the relative density of 1.10 at the temperature of 55 ℃;
step 3, adding 50-100 ml of 25% sucrose into the clear paste obtained in the step 2, uniformly stirring at the stirring speed of 50 times/min, and then adding water to 1000 ml;
and 4, standing for 24 hours, filtering, adding water to 1000ml, and filling to obtain the gardenia jasminoides oral liquid.
In the step 2, the standing time is 15-30 min.
The beneficial effects of the present invention are illustrated by clinical animal tests as follows.
Experimental example 1 treatment of piglet diarrhea
Test drugs: the gardenia jasminoides oral liquid prepared in the example 1, the example 2, the example 3 and the example 4 is taken as an experimental group medicament, and a reference medicament is commercially available 5% florfenicol powder.
Test animals: 60 piglets with diarrhea in 45-80 days old
The test method comprises the steps of randomly dividing 60 pigs into 6 groups, wherein each group comprises 10 pigs, the first 4 groups are experimental groups, the dosage of each 1L water is 1.0-1.5 ml, the 5 th group is a florfenicol powder control group, the 6 th group is a blank control group, no drug is added, normal feeding and free drinking (during and after drug administration) are carried out, and the pigs are continuously observed for 21 days.
The treatment effect judgment standard is invalid, wherein the pigs which have no effect or have unobvious effect in the administration and observation period are regarded as invalid, and the pigs which have no effect or insignificant effect in the administration and observation period are regarded as valid, wherein the pigs which have no effect or have no effect in the administration and observation period are regarded as valid, and the pigs which have no effect have appetite and improved mental state or are completely cured are regarded as valid; the cure is that various clinical symptoms disappear, the diarrhea stops, the appetite and the mental state are good, and the disease does not relapse after the medicine is stopped for one week. The test results and analytical test results are shown in Table 1.
TABLE 1 piglet diarrhea treatment results
| Group of | Number of pigs tested (head) | Number of pigs cured | Cure rate (%) | Total effective pig number (head) | Total effective rate (%) |
| Experimental group 1 | 10 | 7 | 70％ | 8 | 80％ |
| Experimental group 2 | 10 | 7 | 70％ | 9 | 90％ |
| Experimental group 3 | 10 | 8 | 8％ | 10 | 100％ |
| Experimental group 4 | 10 | 9 | 90％ | 10 | 100％ |
| Control group | 10 | 7 | 70％ | 8 | 80％ |
| Blank control group | 10 | 2 | 20％ | 4 | 40％ |
The test result shows that (1) compared with a blank control group without medicines, the other groups treated by medicines have good cure rate and effective rate. The cure rate is more than 70%, and the effective rate is more than 80%; (2) compared with the control group, the experimental groups 1 and 2 have insignificant difference of the cure rate and the effective rate, and compared with the control group, the experimental groups 3 and 4 have obviously better cure rate and effective rate than the control group. The experiments prove that compared with the chemical drug florfenicol powder, the gardenia oral liquid has equivalent or even better treatment effect on common diarrhea of piglets.
Experimental example 2 treatment of pullorum disease
Test drugs: the gardenia jasminoides oral liquid prepared in the example 1, the example 2 and the example 3 is taken as an experimental group medicament, and a control group medicament is commercially available 5% florfenicol powder.
Test animals: 50 chicks with diarrhea
The test method comprises the steps of randomly dividing 50 chickens into 5 groups, wherein each group comprises 10 chickens, the first 3 groups are experimental groups, the dosage of each 1L water is 1.5-2.5 ml, the 4 th group is a florfenicol powdered drug control group, the 5 th group is a blank control group, the chickens are not administrated, and the chickens are continuously observed for 21 days after normal feeding and free drinking (during and after administration).
The treatment effect judgment standard is invalid, wherein the chicken which has no effect or has no obvious effect in the administration and observation period is regarded as invalid, and the chicken which has the effects of relieving various clinical symptoms, obviously reducing abdominal times, improving appetite and mental state or completely curing is regarded as valid; the cure is that various clinical symptoms disappear, the diarrhea stops, the appetite and the mental state are good, and the disease does not relapse after the medicine is stopped for one week. The test results and analytical test results are shown in Table 2.
TABLE 2 treatment results for diarrhea in chicks
| Group of | Test chicken number (only) | Number of cured chicken | Cure rate (%) | Total effective number of chickens (only) | Total effective rate (%) |
| Experimental group 1 | 10 | 7 | 70％ | 8 | 80％ |
| Experimental group 2 | 10 | 8 | 80％ | 9 | 90％ |
| Experimental group 3 | 10 | 8 | 8％ | 9 | 90％ |
| Control group | 10 | 7 | 70％ | 8 | 80％ |
| Blank control group | 10 | 1 | 10％ | 1 | 10％ |
The test result shows that (1) compared with a blank control group without medicines, the other groups treated by medicines have good cure rate and effective rate. The cure rate is more than 70%, and the effective rate is more than 80%; (2) compared with the control group, the experimental group 1 has no obvious difference in the cure rate and the effective rate, and compared with the control group, the experimental groups 2 and 3 have obviously better cure rate and effective rate than the control group. The experiments prove that compared with the chemical florfenicol powder, the gardenia jasminoides oral liquid has equivalent or even better treatment effect on common diarrhea of chicks.
Claims (6)
1. The formula of the gardenia jasminoides oral liquid with the effects of cooling blood and stopping dysentery is characterized by comprising the following medicinal components: coptis root, scutellaria baicalensis, gardenia, common andrographis herb, Chinese pulsatilla root, liquorice and purified water.
2. The formula of the gardenia jasminoides oral liquid with the effect of cooling blood and stopping dysentery according to claim 1, which is characterized by comprising the following medicinal components in parts by mass: 200 to 350g of coptis root, 450 to 750g of scutellaria root, 400 to 650g of gardenia, 200 to 350g of common andrographis herb, 200 to 350g of Chinese pulsatilla root, 100 to 250g of liquorice and purified water.
3. The formula of the gardenia jasminoides oral liquid with the effect of cooling blood and stopping dysentery according to claim 2, which is characterized by comprising the following medicinal materials in parts by mass: 350g of coptis root, 750g of scutellaria root, 650g of cape jasmine fruit, 350g of andrographis paniculata, 350g of Chinese pulsatilla root, 250g of liquorice and purified water.
4. The formula of the gardenia jasminoides oral liquid with the effect of cooling blood and stopping dysentery according to claim 2, which is characterized by comprising the following medicinal materials in parts by mass: 200g of coptis chinensis, 450g of scutellaria baicalensis, 400g of cape jasmine, 200g of andrographis paniculata, 200g of Chinese pulsatilla root, 100g of liquorice and purified water.
5. The preparation process of the formula of the gardenia jasminoides oral liquid with the effects of cooling blood and stopping dysentery according to claim 2, which is characterized by comprising the following steps:
step 1, weighing 200-350 g of coptis chinensis, 450-750 g of scutellaria baicalensis, 400-650 g of gardenia, 200-350 g of andrographis paniculata, 200-350 g of Chinese pulsatilla root and 100-250 g of liquorice, adding water into the six medicinal materials of the coptis chinensis, the scutellaria baicalensis, the gardenia, the andrographis paniculata, the Chinese pulsatilla root and the liquorice, decocting the two medicinal materials twice, and combining and decocting the two medicinal materials to obtain basic liquid medicine;
step 2, filtering the basic liquid medicine obtained in the step 1 to obtain filtrate, and then concentrating the filtrate into clear paste with the relative density of 1.10 at the temperature of 55 ℃;
step 3, adding 50-100 ml of 25% sucrose into the clear paste obtained in the step 2, uniformly stirring, and then adding water to 1000 ml;
and 4, standing for 24 hours, filtering, adding water to 1000ml, and filling to obtain the gardenia jasminoides oral liquid.
6. The preparation process of the formula of the gardenia jasminoides oral liquid with the effect of cooling blood and stopping dysentery according to claim 2, wherein in the step 2, the stirring speed is 50 times/min.
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| CN101850008A (en) * | 2010-06-08 | 2010-10-06 | 江西中成药业集团有限公司 | Bacillus Ling oral liquid and preparation method thereof |
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