CN103720779A - High-stability ultramicropowder agent capable of supporting healthy energy and eliminating toxin - Google Patents
High-stability ultramicropowder agent capable of supporting healthy energy and eliminating toxin Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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Abstract
The invention relates to a medicine capable of supporting healthy energy and eliminating toxin, particularly a high-stability ultramicropowder agent capable of supporting healthy energy and eliminating toxin. The invention is characterized in that the ultramicropowder agent is prepared from the following components in parts by weight: 60 parts of radix isatidis, 60 parts of radix astragali, 30 parts of epimedium and 10-16 parts of rhubarb. The medicine is pulverized into ultramicropowder, and mixed with 13-17 parts of pentaerythritol ultramicropowder to obtain the ultramicropowder agent. The formula is improved: the conventional rhubarb for purging intense heat and eliminating toxin is added; and the ultramicropowder agent can not cause diarrhoea of animals, but has obvious curative effect on fever symptoms of the animals. The ultramicropowder agent is preferably a specific dispersing agent, thereby obviously prolonging the stable period of the product, preventing moisture absorption and lumping, prolonging the shelf life of the medicine, lowering the medicine cost and avoiding waste of resources. The formula is still simple, and still has the original functions of the powder capable of supporting healthy energy and eliminating toxin.
Description
Technical field
The present invention relates to veterinary drug, be specifically related to Fuzheng Jiedu medicine, this medicine has the effect that strengthens poultry immunity of organisms, also has antipyretic antiviral effect simultaneously.
Background technology
In 2010 editions < < Chinese veterinary pharmacopoeia > > (being called for short: pharmacopeia 2010 editions), record " Fuzheng Jiedu powder ", by Radix Isatidis 60g, Radix Astragali 60g and Herba Epimedii 30g, formed; Energy strengthening vital QI to eliminate pathogenic factors, heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI.Repair immune cell function, induction body produces interferon, reconditioner body immunity function; Protect the liver and protect kidney, detoxication and toxicant eliminating function, the various secondary infection that porcine circovirus is caused have specially good effect.Cure mainly infectious bursal disease.The infectious disease that other virus is caused is all effective in cure.
Therefore clinical in for infectious bursal disease.Also as prophylactic agent, use, for improve poultry immunity, prevent that sub-health state from occurring, adjust animal body each organ functional status, make body in best physiological status, life-time service purifying aquaculture field viral disease.
Nearly all antiviral chemical synthetic drug is prohibited as the use of amantadine, ribavirin, moroxydine etc. is all subject to the Ministry of Agriculture at present.Therefore, Traditional Chinese Medicine Anti virus becomes technology trends.Under this background, have chicken, duck, the isometric conventional livestock and poultry virus sexually transmitted disease of pig are had to extensive curative effect, formula is simple, and lower-cost Fuzheng Jiedu powder becomes the further focus of research and development of field of veterinary.And dosage form, preparation process that current technical research direction is mainly improvement Fuzheng Jiedu powder improve its drug absorption and utilization rate, improve clinical efficacy.For example have and to be prepared as oral liquid, have and be prepared as superfine powder.These technology have all played good facilitation to the application clinical of this medicine; But only limited from dosage form and technologic room for improvement, be difficult to realize technological break-through.
In addition, still there is clinically very large deficiency in existing Fuzheng Jiedu powder: the Fuzheng Jiedu powder itself as prophylactic does not have good refrigeration function, and animal hyperpyrexia, fervescence are not improved significantly; Must coordinate antibiotic or other antipyretic analgesicses to use.So just cause the inconvenience of clinical animal isolation and medication.Otherwise, if if Fuzheng Jiedu powder can possess good refrigeration function, even if there is certain clinical symptoms in animal, because avoided hyperpyrexia, high heat, so substantially can keep the good mental status, appetite, and in conjunction with the adjusting immunization of Fuzheng Jiedu powder recovers voluntarily without use antibiotic.Can facilitate medication, reduce costs again, and reduce drug dependence.
The technology of also not improving in the art Fuzheng Jiedu powder refrigeration function is open.According to industry regulation, do not allow antipyretic chemicals to add yet, and if add, can cause healthy animal body to be forced to absorb antipyretic yet, fail to avoid drug dependence.And for example adding conventional heat clearing Chinese medicine: Gypsum Fibrosum, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Flos Lonicerae, Radix Rehmanniae etc., be also difficult to the effect that reaches good through overtesting; Or improve miopragias such as separating when thermal effect original antiviral, or formula is comparatively complicated little with existing anti virus herb difference.
Therefore as added a small amount of raw material of Chinese medicine, at the refrigeration function that keeps improving under formula simplification, the former resultful prerequisite of medicine Fuzheng Jiedu powder, be one of this area technical barrier.
Summary of the invention
The Fuzheng Jiedu superfine powder that the object of this invention is to provide a kind of high stable, this medicine has good stability.
For achieving the above object, the present invention adopts following technical scheme:
A Fuzheng Jiedu superfine powder for high stable, is characterized in that: consisting of by weight: 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei 10-16 part; Described medicine is pulverized as superfine powder, and mixes tetramethylolmethane superfine powder 13-17 part and obtain superfine powder.
Preferably, 12 parts of described Radix Et Rhizoma Rhei.
Preferably, 15 parts of described tetramethylolmethane superfine powder.
Compared with prior art, the invention has the beneficial effects as follows:
1, improve formula, increased the conventionally Radix Et Rhizoma Rhei for heat and toxic materials clearing away, eliminating fire and detoxication; Not only can not cause that animal has loose bowels, dysentery; On the contrary the heating paresthesia of animal is played to significant curative effect.
2, guarantee human body energy and the vigor of animal, coordinate medicine itself to have enhancing immunization, can significantly improve anti-virus ability, animal viral disease infection rate significantly reduces.Keep the good growth tendency of animal.
3, reduce antibiotic use, avoided poultry to produce drug resistance and immunity reduction.Facilitate clinical application, reduce the cost of cultivation.
4, preferred specific dispersant in superfine powder, can significantly improve the stable period of product, and the square moisture absorption, anti-caking, improve the medicine shelf-life, reduces medicine cost, avoids the wasting of resources.
5, formula is still comparatively simple, and keeps the original various functions of Fuzheng Jiedu powder.
Therefore, in fact the present invention can be understood as and be to provide: there is heat clearing away, improve the Fuzheng Jiedu medicine of poultry immunity of organisms, or heat-clearing and toxic substances removing antiviral powder agent medicine, or the Fuzheng Jiedu superfine powder medicine of high stable.
The specific embodiment
Provide preferred embodiment below, so that those skilled in the art are more clear and technical scheme clearly of the present invention and useful technique effect.But enforcement of the present invention is not limited in the following example.Simultaneously do not prove that formula of the present invention is unique particular requirement yet, but allow to be reasonably equal to the error of replacement and commercial production, clinical practice.
Embodiment mono-
By weight: 10 parts of 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei.Powder is pulverized, crosses and sieve for No. five, mixed to obtain to medicine material jointly.
Embodiment bis-
By weight: 12 parts of 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei.Medicine was pulverized respectively No. five sieves, was mixed to obtain powder.
Embodiment tri-
By weight: 16 parts of 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei.Medicine was pulverized respectively No. five sieves, was mixed to obtain powder.
Embodiment tetra-
By weight: 12 parts of 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei.By following steps, be prepared as oral liquid:
1) four Chinese medicine thing shreds below 2cm size, adds 1.2 times of weight water soakings 30 minutes;
2) boil that rear maintenance is micro-boils 1 hour, filter;
3) filtering residue adds micro-boiling 45 minutes after 1 times of weight water boil, filters;
4) merge the filtrate of twice, be concentrated into former medicine etc. heavily and get final product.
Embodiment five
By weight: 13 parts of 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei.
By following steps, be prepared as oral liquid:
1) four Chinese medicine thing shreds below 2cm size, adds 1.2 times of weight water soakings 30 minutes;
2) boil that rear maintenance is micro-boils 1 hour, filter;
3) filtering residue adds micro-boiling 45 minutes after 1 times of weight water boil, filters;
4) merge the filtrate of twice, be concentrated into former medicine etc. heavily and get final product.
Embodiment six
By weight: 12 parts of 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei.Described medicine is pulverized as superfine powder (particle diameter 10 μ m are following), and mixes 15 parts of tetramethylolmethane superfine powder (particle diameter 10 μ m are following) and obtain superfine powder.
Embodiment seven
By weight: 13 parts of 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei.Described medicine is pulverized as superfine powder (particle diameter 10 μ m are following), and mixes 16 parts of tetramethylolmethane superfine powder (particle diameter 10 μ m are following) and obtain superfine powder.
Comparative example one
Dispersant: 8 parts of tetramethylolmethane superfine powder (particle diameter 10 μ m are following), all the other are with embodiment six.
Comparative example two
Dispersant: 20 parts of tetramethylolmethane superfine powder (particle diameter 10 μ m are following), all the other are with embodiment six.
Comparative example three
Dispersant: 15 parts of microcrystalline Cellulose (particle diameter 10 μ m are following), all the other are with embodiment six.
Comparative example four
Dispersant: 15 parts of starch (particle diameter 10 μ m are following), all the other are with embodiment six.
Comparative example five
Dispersant: 15 parts of calcium hydrogen phosphate (particle diameter 10 μ m are following), all the other are with embodiment six.
Stability test
1. materials and methods: the Fuzheng Jiedu medicine of getting embodiment mono-to seven, according to appendix medicine stability experimental technique of < < Chinese veterinary pharmacopoeia > > version in 2010, carry out hot and humid high light and accelerate experiment, press commercially available back, 40 ± 2 ℃ of temperature, relative humidity 75 ± 5%, in the medicine stability experimental box (Chongqing immortality experimental apparatus factory) of illumination 4500 ± 500LX, place 6 months, at experimental session the 1st, 2, 3, sample respectively once 6 the end of month, to the character of powder, content, granularity, the outward appearance uniformity, settling volume ratio, redispersibility is investigated, result is all qualified.Because the safety and stability of conventional Chinese medicine is comparatively reliable, the medication taboo general knowledge that the present invention does not also go against the established rules, therefore test data repeats no more in detail.
2. superfine powder medicine stability contrast
Totally 7 groups of medicines to embodiment six, seven and comparative example one to five sample respectively once at experimental session the 1st, 2,3,6 the end of month, contrast caking situation, water absorption rate, and fineness situation, test data is as shown in table 1 below.
The stability experiment data of table 1 superfine powder
Visible, the present invention adopts the tetramethylolmethane superfine powder superfine powder of specified weight to do dispersant, and superfine powder stability significantly improves.
Veterinary clinic effect
1. pair infectious bursal disease curative effect
Choose the morbidity chicken group of Hechuan, Chongqing, Tongnan area plant, 250 of broiler that therefrom select and do not used any Drug therapy, are diagnosed as infectious bursal disease through clinical observation, laboratory diagnosis, are divided into 5 groups, 50 every group at random.
Test group 1 is added the Fuzheng Jiedu medicine that embodiment 2 makes in feedstuff;
Test group 2 is added the Fuzheng Jiedu medicine that embodiment 4 makes in feedstuff;
Test group 3 is added the Fuzheng Jiedu medicine that embodiment 6 makes in feedstuff;
Test group 4 is added the Fuzheng Jiedu medicine that embodiment 7 makes in feedstuff;
Matched group 1 adds the Fuzheng Jiedu medicine by 2010 editions preparations of pharmacopeia in feedstuff.
All by every chicken, give mixed feeding in the quantity set of 1g every day; Continuous use 3 days separately, stops observation post administration 1 week.
Curative effect judging standard
Cure: after test chicken administration, the clinical symptoms such as lassitude, diarrhoea, row faint yellow or linen not sample loose stool, dehydration all disappear; And the recoveries such as spirit, appetite, feces, breathing are normal for curing.
Effective: all at experimental session, after chicken medication, the spirit of test chicken, appetite, breathing are clearly better as effectively.
Invalid: duration of test, there is classical symptom the death of infectious bursal disease in test chicken, after necropsy, visible chest muscle, lower limb flesh, glandular stomach, kidney and bursal disease etc. have the change of typical feature disease, all can be judged to be to infect death or symptom and do not alleviate or continue deterioration for invalid.
Experimental result is as shown in the table:
The case of the not newly-increased dysentery of experimental group, the symptom of having loose bowels.The effect of Fuzheng Jiedu medicine of the present invention aspect treatment chicken bursal disease is not second to existing powder effect as can be seen here.And add the side effect such as Radix Et Rhizoma Rhei does not cause that chicken has loose bowels yet.
2. refrigeration function effect
Choose that large-scale pig farm, Hechuan feeding and management condition is basic identical, close, the swine fever of birth age in days or swine influenza heating, body temperature, 57 of 39.0 ± 5 ℃ of cases, is divided into 3 groups at random, 19 every group.
Experimental group one: in the ratio that every day, per kilogram of body weight was added the Fuzheng Jiedu medicine 1g that embodiment 6 makes in feedstuff, feed, disposable feeding intake;
Experimental group one: in the ratio that every day, per kilogram of body weight was added the Fuzheng Jiedu medicine 1g that embodiment 7 makes in feedstuff, feed, disposable feeding intake;
Matched group one: by every day per kilogram of body weight in feedstuff, add 5g10% tilmicosin pre-mixing agent, 1g by the Fuzheng Jiedu medicine of 2010 editions preparations of pharmacopeia, disposable feeding intake;
Matched group two: by every day per kilogram of body weight in feedstuff, add 1g by the Fuzheng Jiedu medicine of 2010 editions preparations of pharmacopeia, disposable feeding intake.
Each group is all used 3 days continuously, and other condition such as feeding and management is identical.Then within 2 hours, 24 hours, 48 hours, 72 hours, 144 hours after feeding for the first time, measure anus temperature, record data, the results are shown in following table:
Swine fever or the antipyretic result of the test of swine influenza fever patients (℃, ± S)
Can find out: after 2 hours, use the temperature of pig body of medicine of the present invention obviously to decline, within 24 hours, return to normal level.Use the test group of tilmicosin pre-mixing agent and existing Fuzheng Jiedu medicine to show the performance suitable with medicine of the present invention.Use merely existing Fuzheng Jiedu medicine sick temperature of pig body obviously not to be treated and improve effect.The sick body of two test group can substantially can in 24 hours, refresh state and appetite, without using other antibiotic or antiviral drugs to fully recover voluntarily.Promote better animal recover more afterwards and grow.Reducing antibiotic uses.And experimental group 1,2 is not newly-increased dysentery case also.The sick body of matched group two all needs to use antibiotic therapy to fully recover, and has a routine Relapse rate death.
To 1355 chickens of chicken house, in feedstuff, by once a day, the prevention consumption of each per kilogram of body weight 0.5g is fed in addition; 1200 of matched groups do not add medicine, in the identical situation of other condition.The infectious bursal disease morbidity example of experimental group chicken is 5.02%, and matched group is 31%.Same scale of feeding is in the situation that other condition is identical, and experimental group swine influenza sickness rate is 1.62%, and matched group is 23%.Also do not occur the phenomenon of suffering from diarrhoea, drawing tripe symptom to increase because of medication, visible medicine of the present invention can regulate animal body immunity, strengthens anti-virus ability.
Claims (3)
1. a Fuzheng Jiedu superfine powder for high stable, is characterized in that: consisting of by weight: 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii 30, Radix Et Rhizoma Rhei 10-16 part; Described medicine is pulverized as superfine powder, and mixes tetramethylolmethane superfine powder 13-17 part and obtain superfine powder.
2. the Fuzheng Jiedu superfine powder of high stable according to claim 1, is characterized in that: 12 parts of described Radix Et Rhizoma Rhei.
3. the Fuzheng Jiedu superfine powder of high stable according to claim 1, is characterized in that: 15 parts of described tetramethylolmethane superfine powder.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610181343.1A CN105832828A (en) | 2014-01-06 | 2014-01-06 | Preparation method of healthy-energy-strengthening and body-detoxifying ultrafine powder agent for livestock and poultry |
| CN201410005571.4A CN103720779B (en) | 2014-01-06 | 2014-01-06 | The Fuzheng Jiedu superfine powder of high stable |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410005571.4A CN103720779B (en) | 2014-01-06 | 2014-01-06 | The Fuzheng Jiedu superfine powder of high stable |
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| CN201610176813.5A Division CN105726660A (en) | 2014-01-06 | 2014-01-06 | Body resistance strengthening and toxin removing ultrafine powder for livestock and poultry |
| CN201610180425.4A Division CN105708910A (en) | 2014-01-06 | 2014-01-06 | Preparation method of powder for clearing away heat and toxic materials of livestock and poultry |
| CN201610181343.1A Division CN105832828A (en) | 2014-01-06 | 2014-01-06 | Preparation method of healthy-energy-strengthening and body-detoxifying ultrafine powder agent for livestock and poultry |
| CN201610182728.XA Division CN105770019A (en) | 2014-01-06 | 2014-01-06 | Heat-clearing and detoxifying powder for livestock and poultry |
| CN201610182799.XA Division CN105748616A (en) | 2014-01-06 | 2014-01-06 | Preparation method of heat-clearing and toxin-removing oral liquid for livestock and poultry |
| CN201610176792.7A Division CN105726659A (en) | 2014-01-06 | 2014-01-06 | Heat clearing and toxin removing oral liquid for livestock and poultry |
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| CN103720779A true CN103720779A (en) | 2014-04-16 |
| CN103720779B CN103720779B (en) | 2016-04-20 |
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| CN201410005571.4A Expired - Fee Related CN103720779B (en) | 2014-01-06 | 2014-01-06 | The Fuzheng Jiedu superfine powder of high stable |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106309662A (en) * | 2015-06-24 | 2017-01-11 | 罗永辉 | Medicine for treating pullorum disease |
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| CN110051735A (en) * | 2019-04-30 | 2019-07-26 | 河北维尔利动物药业集团有限公司 | Livestock and poultry Fuzheng Jiedu broken wall superfine powder and its preparation process |
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- 2014-01-06 CN CN201610181343.1A patent/CN105832828A/en active Pending
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| CN103720779B (en) | 2016-04-20 |
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