CN102389499B - Traditional Chinese medicinal extract used for controlling viral diseases in aquiculture and preparation method thereof - Google Patents
Traditional Chinese medicinal extract used for controlling viral diseases in aquiculture and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal extract used for controlling viral diseases in aquiculture and a preparation method thereof. The traditional Chinese medicinal extract used for controlling viral diseases is prepared by the following major materials according the part by weight: 40 to 60 of rhubarb, 20 to 40 of membranous milkvetch root, 15 to 25 of pilose asiabell root, 20 to 25 of pomegranate bark, 15 to 25 of indigowoad leaf, 20 to 30 of indigowoad root, 15 to 25 of Epimedium, 20 to 30 of divaricate saposhnikovia, 15 to 25 of Peucedanum, 10 to 20 of liquorice root and 20 to 30 of peppermint. The preparation method comprises the steps as follows: weighing the materials, grinding, extracting with an ethanol aqueous solution twice, collecting filtrates, and distilling the filtrates under reduced pressure to obtain the traditional Chinese medicinal extract. The extract can regulate the color of water and improve feed attractant in aquatic animals, has the characteristics of removing heat and toxic substances and improving immunity of aquatic animals, can inhibit the growth and reproduction of bacteria and viruses, and is used for treating various diseases caused by bacteria and viruses. The extract is convenient to administrate and has no drug residues or toxic side effects.
Description
Technical field
The present invention relates to Chinese medicine extraction liquid of a kind of Disease control and preparation method thereof, particularly a kind of Chinese medicine extraction liquid for the control of aquaculture Disease and preparation method thereof, belongs to Disease and prevents and treats technical field of pharmaceuticals.
Background technology
In recent years, aquaculture scale expands rapidly, and cultural technique improves maturation gradually.Along with the large-scale development of culture fishery, cultured area, cultivation intensity constantly increase, and the ecological environment of cultivation constantly worsens, and disease also becomes increasingly conspicuous, wherein especially with virosis for very.Breaking out with popular of water body animal virosis is not still controlled effectively and solution at all, and the impact causing is large, weight losses.Affect serious common prawn ' s virus and mainly contain white spot virus, taura syudrome, hepatopancreatic parvovirus, Virus disease of fish has hemorrhagic disease of grass carp, spring viremia, infectious pancreatic necrosis, eel virus opening disease etc.Because the Virus parasite infecting is in somatic cell, treat more difficultly, in order effectively to prevent and treat the virosis of aquaculture, scientific research and poultry feeders have carried out various explorations.A large amount of researchs show, under suitable condition, water body animal can be carried viral healthy growth, under environmental catastrophe, water body animal immunizing power, in degradation situation, just can fall ill.So, should prevent and treat targetedly water body animal virosis, create and the suitable growing environment of stable water body animal, improve water body animal immunizing power, kill virus or inhibition virus replication etc.
Current research shows, causes that the principal element of virosis has: virus may be propagated in the following manner:
1. horizontal transmission: propagate by source of disease such as viruliferous sick fish and shrimp, dead fish and shrimp, sea water, mud, after water body zoogenetic infection virus, virus is bred in cell, destroy prawn blood regulating liver-QI pancreatic cell function, cause aquatic animal death, then virus is discharged in water, infects new host.Its main path has: 1. culturing pool mud; 2. the sea water of non-sterile; 3. medium biology, as other crustacean in culturing pool (comprising wild shrimps, Eriocheir sinensis class) and Copepods etc.; 4. sick fish and shrimp, dead fish and shrimp in culturing pool; 5. ingested flying bird, the pool side muroid etc. of viruliferous fish and shrimp; 6. polluted bait etc. by virus.
2. vertical transmission: by viruliferous parent by virus disseminating to seedling.Exist larger possibility for this route of transmission, but still lack at present positive evidence.
Virus can not be lived on one's own life because of it, must parasitize in cell, and amount reproduction copies in vivo, the mode that virus is sprouted by cell rupture or from aquatic animal somatic cell film surface propagates into other cells, also can infect by the approach of horizontal transmission other aquatic animal individuality, aquatic animal by viral infection after, its tissue organ function reduces or loses, and causes subsequently aquatic animal death.To its treatment, must kill theoretically cell, thereby reach the object of elimination virus, this is obviously unpractical.Controlling virus by raising aquatic animal autoimmunity is a more satisfactory approach, but some aquatic animal immunologic functions are very low, and these all make virosis lack effective treatment means.
Also have that viral epiphytotics to break out early stage may be first to be infected by vibrio, water body animal immunizing power declines, now virus can be in short several hours or tens hours propagation in a large number.Also there is scholar to think first viral infection, then for the condition that provides is provided antibacterial.In a word, the situation that infects when virus, antibacterial, infects is each other very general, has increased the weight of the state of an illness of virosis.
The growth conditions of water body animal has determined that antibacterial and viral propagation medium are water, if by the regulation and control of water quality, in antibacterial and virus disseminating process, implement to kill, and improve the immunity of prawn by oral extracting solution, anti-bacteria and viral breeding, controlling breaking out of virosis, is a very effective approach.Grope through years of researches and practice, we sum up strick precaution, the Therapeutic Method of a cover system, set up an office and instruct aquaculture family through large area multizone, all prove successfully effective.
Summary of the invention
The object of this invention is to provide a kind of immunity of organisms, resistance against diseases that can regulate cultivation water and raising aquatic animal, reduce the infection of bacterial virus, improve Chinese medicine extraction liquid of aquatic animal bacterial virus prevention effect and preparation method thereof.
In order to address the above problem, the technical solution adopted in the present invention is:
Chinese medicine extraction liquid of the present invention is to be mainly made up of the raw material of following weight portion:
40～60 parts of Radix Et Rhizoma Rhei, 20～40 parts of the Radixs Astragali, 15～25 parts of Radix Codonopsis, 20～25 parts of Pericarpium Granatis, 15～25 parts of Folium Isatidiss, 20～30 parts of Radix Isatidis, 15～25 parts of Herba Epimedii, 20～30 parts of Radix Saposhnikoviaes, 15～25 parts of Radix Peucedanis, 10～20 parts, Radix Glycyrrhizae, 20～30 parts of Herba Menthaes.
Preferred feedstock proportioning is:
48 parts of Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, 26 parts of Radix Saposhnikoviaes, 20 parts of Radix Peucedanis, 12 parts, Radix Glycyrrhizae, 25 parts of Herba Menthaes.
The method of the Chinese medicine extraction liquid of preventing and treating for the preparation of aquaculture Disease, comprises the following steps:
(1) take each raw material by 20～30 parts of 40～60 parts of Radix Et Rhizoma Rhei, 20～40 parts of the Radixs Astragali, 15～25 parts of Radix Codonopsis, 20～25 parts of Pericarpium Granatis, 15～25 parts of Folium Isatidiss, 20～30 parts of Radix Isatidis, 15～25 parts of Herba Epimedii, 20～30 parts of Radix Saposhnikoviaes, 15～25 parts of Radix Peucedanis, 10～20 parts, Radix Glycyrrhizae, Herba Menthae, pulverize for subsequent use;
(2) raw material of step (1) being pulverized soaks twice with 50% ethanol water, add for the first time the amount of ethanol water not have former charge level to be advisable, soaking at room temperature 20 ~ 30 hours, filters out filtrate, and filtering residue adds ethanol water again, the addition of ethanol water was not to have former charge level to be advisable, soaking at room temperature 20 ~ 30 hours, filters out filtrate, merges twice filtrate, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 50 ~ 70 ℃ of constant temperature concentrating under reduced pressure become proportion.
Chinese medicine of the present invention is got the preparation method of liquid, comprises the following steps:
1, described weight ratio takes each raw material preferably: 48 parts of Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, 26 parts of Radix Saposhnikoviaes, 20 parts of Radix Peucedanis, 12 parts, Radix Glycyrrhizae, 25 parts of Herba Menthaes, pulverize for subsequent use;
2, the raw material of pulverizing is soaked twice with 50% ethanol water, add for the first time ethanol water not have former charge level to be advisable, soaking at room temperature 24 hours, filter out filtrate, then add ethanol water not have former charge level, soaking at room temperature 24 hours, merge filtrate twice, by six layers of filtered through gauze twice, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 60 ℃ of constant temperature concentrating under reduced pressure become proportion.
The invention has the beneficial effects as follows:
The present invention selects above-mentioned raw materials combination to make each component and effect produce synergism, thereby can improve immunity of organisms, the resistance against diseases of aquatic animal, reduces the infection of bacterial virus, improves the prevention effect of water body animal bacteria virus.
Wherein selecting Radix Et Rhizoma Rhei is because of its purging heat to relax the bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass clots absorbing.Selecting the Radix Astragali is because of its tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Selecting Radix Codonopsis is because of its invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Select Pericarpium Granati to be because its relieving diarrhea with astringents stops blooding, anthelmintic.Selecting Folium Isatidis is because of its heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Selecting Radix Isatidis is because of its heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Selecting Herba Epimedii is because of its kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Select Radix Saposhnikoviae to be because its inducing diaphoresis to dispel wind wins and wets, spasmolytic.Selecting Radix Peucedani is because of its lowering the adverse-rising QI to resolve phlegm, wind and heat dispersing.Selecting Radix Glycyrrhizae is because of its invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong.Selecting Herba Menthae is because of its wind-dispelling heat-dissipating, the clear sharp head, sore-throat relieving, rash.This prescription has antiviral, antibacterium, heat-clearing and toxin-vanquishing, removing heat from the liver, antibiotic and sterilizing, improve resistance against diseases, stop Virus entry host cell, suppress its DNA and RNA synthetic, suppress viral growth breeding and play antiviral effect.
Chinese medicine extraction liquid of the present invention can regulating water quality, anti-bacteria and viral growth breeding, and convenient drug administration, widely distributed, drug residue free, has no side effect, and safety range is wide.
The specific embodiment
Below by embodiment, the present invention is described in further details, these embodiment are only used for illustrating the present invention, do not limit the scope of the invention.
Embodiment 1
No. 1 preparation of Chinese medicine extraction liquid of the present invention
1, take 40 parts of raw material Radix Et Rhizoma Rhei, 25 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 18 parts of Pericarpium Granatis, 20 parts of Folium Isatidiss, 22 parts of Radix Isatidis, 16 parts of Herba Epimedii, 22 parts of Radix Saposhnikoviaes, 18 parts of Radix Peucedanis, 10 parts, Radix Glycyrrhizae, 21 parts of Herba Menthaes, pulverize for subsequent use;
2, the raw material of pulverizing is soaked twice with 50% ethanol water, add for the first time ethanol water not have former charge level to be advisable, soaking at room temperature 24 hours, filter out filtrate, then add ethanol water not have former charge level, soaking at room temperature 24 hours, merge filtrate twice, by six layers of filtered through gauze twice, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 50 ℃ of constant temperature concentrating under reduced pressure become proportion.
Embodiment 2
No. 2 preparations of Chinese medicine extraction liquid of the present invention
1, take 55 parts of raw material Radix Et Rhizoma Rhei, 35 parts of the Radixs Astragali, 25 parts of Radix Codonopsis, 25 parts of Pericarpium Granatis, 25 parts of Folium Isatidiss, 30 parts of Radix Isatidis, 25 parts of Herba Epimedii, 30 parts of Radix Saposhnikoviaes, 25 parts of Radix Peucedanis, 16 parts, Radix Glycyrrhizae, 30 parts of Herba Menthaes, pulverize for subsequent use;
2, the raw material of pulverizing is soaked twice with 50% ethanol water, add for the first time ethanol water not have former charge level to be advisable, soaking at room temperature 24 hours, filter out filtrate, then add ethanol water not have former charge level, soaking at room temperature 24 hours, merge filtrate twice, by six layers of filtered through gauze twice, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 60 ℃ of constant temperature concentrating under reduced pressure become proportion.
Embodiment 3
No. 3 preparations of Chinese medicine extraction liquid of the present invention
1, take 48 parts of raw material Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, 26 parts of Radix Saposhnikoviaes, 20 parts of Radix Peucedanis, 12 parts, Radix Glycyrrhizae, 25 parts of Herba Menthaes, pulverize for subsequent use;
2, the raw material of pulverizing is soaked twice with 50% ethanol water, add for the first time ethanol water not have former charge level to be advisable, soaking at room temperature 24 hours, filter out filtrate, then add ethanol water not have former charge level, soaking at room temperature 24 hours, merge filtrate twice, by six layers of filtered through gauze twice, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 70 ℃ of degree constant temperature concentrating under reduced pressure become proportion.
Embodiment 4
Safety experiment of the present invention:
In three fishponds, carry out safety testing, Ctenopharyngodon idellus 50 tails are put in each fishpond in a suitable place to breed.First fishpond adds 5ml Disease control of the present invention extracting solution No. 1 in the feedstuff of every day; Second fishpond adds 5ml Disease control of the present invention extracting solution No. 2 in the feedstuff of every day; The 3rd fishpond adds 5ml Disease control of the present invention extracting solution No. 3 in the feedstuff of every day.Observe 30 days.
In 30 days, the fish in three fishponds is all without abnormal, the depressed or phenomena of mortality that are a cup too low, well-grown.Illustrate that Disease control Chinese medicine extraction liquid security performance of the present invention is good.
Embodiment 5
The preventive effect of the present invention to aquaculture viral disease:
In four fishponds, carry out the test of Disease preventive effect.Each 30 tails of Ctenopharyngodon idellus, heavily approximately 100～150g of every urosome are put in each pond.Normally feed every day in first fishpond; Throw something and feed with 1 gram of spice of 5% amantadine hydrochloride soluble powder every day in second fishpond; The 3rd fishpond adds No. 1 1ml spice of Disease control extracting solution of the present invention to throw something and feed; The 4th pond adds No. 3 1ml spices of Disease control extracting solution of the present invention to throw something and feed;
Raise after one week, in four fishponds, respectively put into respectively a Ctenopharyngodon idellus of suffering from hemorrhagic disease of grass carp, observe the growing state of fish in each fishpond.The results are shown in Table 1.Result shows that Disease control extracting solution of the present invention has obvious preventive and therapeutic action to hemorrhagic disease of grass carp.
Table 1: the preventive effect of Chinese medicine extraction liquid of the present invention to hemorrhagic disease of grass carp
Embodiment 6
The therapeutical effect of the present invention to aquaculture viral disease
With Ctenopharyngodon idellus 200 tails of suffering from hemorrhagic disease of grass carp, be divided at random four groups, every group of 50 tails, normally feed first group of every day; Second group adds 2 grams of 5% amantadine hydrochloride soluble powders, and spice is thrown something and fed; The 3rd group with 2 grams of No. 2, Disease of the present invention control extracting solution, and spice is thrown something and fed; The 4th group with 2 grams of No. 3, Disease of the present invention control extracting solution, and spice is thrown something and fed;
Raise after one week, observe the growing state of all Ctenopharyngodon idellus.The results are shown in Table 2: result shows, medicine of the present invention has obvious therapeutical effect to hemorrhagic disease of grass carp.
Table 2: Disease control Chinese medicine of the present invention is got the therapeutical effect of liquid to hemorrhagic disease of grass carp
Claims (6)
1. for a Chinese medicine extraction liquid for aquaculture Disease control, it is characterized in that: the raw material by following weight portion is made:
20～30 parts of 40～60 parts of Radix Et Rhizoma Rhei, 20～40 parts of the Radixs Astragali, 15～25 parts of Radix Codonopsis, 20～25 parts of Pericarpium Granatis, 15～25 parts of Folium Isatidiss, 20～30 parts of Radix Isatidis, 15～25 parts of Herba Epimedii, 20～30 parts of Radix Saposhnikoviaes, 15～25 parts of Radix Peucedanis, 10～20 parts, Radix Glycyrrhizae and Herba Menthaes.
2. for a Chinese medicine extraction liquid for aquaculture Disease control, it is characterized in that:
1), take 40 parts of raw material Radix Et Rhizoma Rhei, 25 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 18 parts of Pericarpium Granatis, 20 parts of Folium Isatidiss, 22 parts of Radix Isatidis, 16 parts of Herba Epimedii, 22 parts of Radix Saposhnikoviaes, 18 parts of Radix Peucedanis, 10 parts, Radix Glycyrrhizae, 21 parts of Herba Menthaes, pulverize for subsequent use;
2), the raw material of pulverizing is soaked twice with 50% ethanol water, add for the first time ethanol water not have former charge level to be advisable, soaking at room temperature 24 hours, filter out filtrate, then add ethanol water not have former charge level, soaking at room temperature 24 hours, merge filtrate twice, by six layers of filtered through gauze twice, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 50 ℃ of constant temperature concentrating under reduced pressure become proportion.
3. for a Chinese medicine extraction liquid for aquaculture Disease control, it is characterized in that:
1), take 55 parts of raw material Radix Et Rhizoma Rhei, 35 parts of the Radixs Astragali, 25 parts of Radix Codonopsis, 25 parts of Pericarpium Granatis, 25 parts of Folium Isatidiss, 30 parts of Radix Isatidis, 25 parts of Herba Epimedii, 30 parts of Radix Saposhnikoviaes, 25 parts of Radix Peucedanis, 16 parts, Radix Glycyrrhizae, 30 parts of Herba Menthaes, pulverize for subsequent use;
2), the raw material of pulverizing is soaked twice with 50% ethanol water, add for the first time ethanol water not have former charge level to be advisable, soaking at room temperature 24 hours, filter out filtrate, then add ethanol water not have former charge level, soaking at room temperature 24 hours, merge filtrate twice, by six layers of filtered through gauze twice, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 60 ℃ of constant temperature concentrating under reduced pressure become proportion.
4. for a Chinese medicine extraction liquid for aquaculture Disease control, it is characterized in that:
1), take 48 parts of raw material Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, 26 parts of Radix Saposhnikoviaes, 20 parts of Radix Peucedanis, 12 parts, Radix Glycyrrhizae, 25 parts of Herba Menthaes, pulverize for subsequent use;
2), the raw material of pulverizing is soaked twice with 50% ethanol water, add for the first time ethanol water not have former charge level to be advisable, soaking at room temperature 24 hours, filter out filtrate, then add ethanol water not have former charge level, soaking at room temperature 24 hours, merge filtrate twice, by six layers of filtered through gauze twice, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 70 ℃ of degree constant temperature concentrating under reduced pressure become proportion.
5. a kind of Chinese medicine extraction liquid for the control of aquaculture Disease according to claim 1, is characterized in that: it is to be made up of the raw material of following weight portion:
25 parts of 48 parts of Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, 26 parts of Radix Saposhnikoviaes, 20 parts of Radix Peucedanis, 12 parts, Radix Glycyrrhizae and Herba Menthaes.
6. for the preparation of a method for the Chinese medicine extraction liquid for the control of aquaculture Disease claimed in claim 1, it is characterized in that:
(1) take each raw material by 20～30 parts of 40～60 parts of Radix Et Rhizoma Rhei, 20～40 parts of the Radixs Astragali, 15～25 parts of Radix Codonopsis, 20～25 parts of Pericarpium Granatis, 15～25 parts of Folium Isatidiss, 20～30 parts of Radix Isatidis, 15～25 parts of Herba Epimedii, 20～30 parts of Radix Saposhnikoviaes, 15～25 parts of Radix Peucedanis, 10～20 parts, Radix Glycyrrhizae and Herba Menthaes, pulverize for subsequent use;
(2) raw material of step (1) being pulverized soaks twice with 50% ethanol water, add for the first time the amount of ethanol water not have former charge level to be advisable, soaking at room temperature 20 ~ 30 hours, filters out filtrate, and filtering residue adds ethanol water again, the addition of ethanol water was not to have former charge level to be advisable, soaking at room temperature 20 ~ 30 hours, filters out filtrate, merges twice filtrate, then in filtrate suction vacuum distillation tower, it is 1.3 extractum that 50 ~ 70 ℃ of constant temperature concentrating under reduced pressure become proportion.
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| CN103494038B (en) * | 2013-09-30 | 2015-08-05 | 江苏省淡水水产研究所 | Anti-white spot syndrome virus Chinese medicine immunity enhancer of a kind of Procambius clarkii and its preparation method and application |
| CN103690617A (en) * | 2014-01-06 | 2014-04-02 | 四川德润通生物科技有限公司 | Antiviral powder capable of clearing heat and removing toxicity |
| CN103720779B (en) * | 2014-01-06 | 2016-04-20 | 四川德润通生物科技有限公司 | The Fuzheng Jiedu superfine powder of high stable |
| CN105726660A (en) * | 2014-01-06 | 2016-07-06 | 四川德润通生物科技有限公司 | Body resistance strengthening and toxin removing ultrafine powder for livestock and poultry |
| CN103705588A (en) * | 2014-01-06 | 2014-04-09 | 四川德润通生物科技有限公司 | Preparation method of high-stability superfine powder for strengthening body resistance and detoxifying |
| CN105770019A (en) * | 2014-01-06 | 2016-07-20 | 四川德润通生物科技有限公司 | Heat-clearing and detoxifying powder for livestock and poultry |
| CN105124200A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of oplegnathidae |
| CN105124201A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of spagrus macrocephalus |
| CN105146140A (en) * | 2015-08-10 | 2015-12-16 | 浙江省海洋开发研究院 | Artificial compound feed for preventing and treating haemorrhage of Japanese flounders |
| CN107373045A (en) * | 2017-07-27 | 2017-11-24 | 张银花 | One kind prevention leukodermal solid feed of lobster and preparation method thereof |
| CN108740555A (en) * | 2018-05-04 | 2018-11-06 | 金寨县康王寨家庭农场 | A kind of nutrition additive for aquaculture |
| CN111587860B (en) * | 2020-06-02 | 2022-05-31 | 长春至应科技有限公司 | Fishing phagostimulant and low-temperature preparation method thereof |
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