CN102028816B - Chinese herbal medicinal compound preparation for treating hemorrhage disease of grass carp - Google Patents
Chinese herbal medicinal compound preparation for treating hemorrhage disease of grass carp Download PDFInfo
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Abstract
The invention relates to a Chinese herbal medicinal compound preparation and a preparation method thereof, in particular to a Chinese herbal medicinal compound preparation for treating the hemorrhage disease of grass carp and a preparation method thereof. The Chinese herbal medicinal compound preparation for treating the hemorrhage disease of the grass carp comprises the following raw materials in parts by weight: 80 to 100 parts of rheum officinale, 40 to 100 parts of smoked plum, 40 to 50 parts of gallnut, 15 to 30 parts of Chinese wingmut leaves, 30 to 50 parts of liquorice, 100 to 150 parts of alternanthera philoxeroides, 50 to 80 parts of datura flower, and 20 to 30 parts of rhizoma ligustici wallichii. Regarding the characteristics of the pathogenesis causing the hemorrhage disease of the grass carp and the symptom, corresponding medicaments are screened to perform symptomatic treatment, so that the hemorrhage disease and corresponding diseases which are generated along with the hemorrhage disease can be effectively treated. The Chinese herbal medicinal compound preparation has no residue, no toxic or side effect, and has remarkable curative effect through clinical application.
Description
[technical field]
The present invention relates to a kind of Chinese herbal compound preparation and preparation method thereof, relate in particular to a kind of Chinese herbal compound preparation that is used to treat hemorrhagic disease of grass carp.
[background technology]
Along with developing rapidly of culture fishery and improving constantly of per unit area yield, the improvement of pond environment condition is but strong inadequately, and aqiuculrue trouble bacterial disease and viral disease situation are more and more serious.Particularly the Ctenopharyngodon idellus of one of China four large Chinese carps is in breeding process, and especially the 4-9 month in its growth busy season, fish diseases harm is comparatively serious, from the fingerling to the adult fish, all very easily infects this disease.Hemorrhagic disease of grass carp is a kind of infectious disease that is caused by reovirus, and sickness rate is up to more than 90%, and death rate of the onset is 30～50%, reaches as high as 60～80%, and fulminant is strong, and harm is big, and all cause great economic loss to the raiser every year.Therefore, the Therapeutic Method of research hemorrhagic disease of grass carp is a ring of most critical during current Ctenopharyngodon idellus is cultured.The treatment difficulty of hemorrhagic disease of grass carp is bigger, up to the present, does not also have a kind of chemicals can treat this disease effectively; The research that Chinese herbal medicine is used for preventing and treating hemorrhagic disease of grass carp has certain effect; Commonly used is Radix Isatidis or SANHUANG (Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei), can prevent and treat hemorrhagic disease of grass carp to a certain extent, but effect is not desirable especially; Can only make survival rate improve 15～30%, the breed loss is still very big.Therefore filtering out a kind ofly has the medicine of significant curative effect to be necessary to hemorrhagic disease of grass carp and syndrome thereof.The Chinese medicine species resource is abundant, filters out can bring into play specific medicine in each morbidity stage of hemorrhagic disease of grass carp and make up, and the thinking of processing Chinese herbal compound preparation is very feasible.
[summary of the invention]
To the problems referred to above, the purpose of this invention is to provide and a kind ofly can effectively treat hemorrhagic disease of grass carp, and other diseases that hemorrhagic disease is supervened are had good therapeutic efficiency, can reduce economic loss, increase Chinese herbal compound preparation of culture benefit and preparation method thereof.
For realizing above-mentioned purpose, the technical scheme that the present invention taked is following:
A kind of Chinese herbal compound preparation that is used to treat hemorrhagic disease of grass carp comprises the raw material of following parts by weight: Radix Et Rhizoma Rhei 80-100 part, Fructus Mume 40-100 part; Galla Chinensis 40-50 part, leaf of Pterocarya Stenoptera 15-30 part, Radix Glycyrrhizae 30-50 part; Water peanut 100-150 part, Flos Daturae 50-80 part, Rhizoma Chuanxiong 20-30 part.
Said each raw material is selected from the crude drug of natural drying or 40～50 ℃ of oven dry.
A kind of method for preparing the Chinese herbal compound preparation of above-mentioned treatment hemorrhagic disease of grass carp is pulverized said raw material, and is crossed 100 mesh sieves through undue appearance, the raw material after will pulverizing is then put into mixer, mixes to get final product in 10 minutes.
During use, the addition of Chinese herbal compound preparation of the present invention in feedstuff is that every 100kg Ctenopharyngodon idellus adds 0.3～1kg.
Should be noted that when using Chinese herbal compound preparation of the present invention prevention, treatment grass carp hemorrhage property disease and complication following some: 1, all of the fish pond that will put in poison are deposited pond fish estimated weight more accurately; According to the consumption of every 100kg Ctenopharyngodon idellus weight, calculate total dose that needs in whole fish pond then; 2, dispensing will be thrown foot according to a course of treatment of total requiremants, guarantees the drug effect accumulative effect; 3, in the medicinal bait of throwing something and feeding, also essential factor pool suiting measures to different conditions is administered the Fish ecological environment, uses sterilization medicine and water transfer product to carry out water quality adjustment, could at utmost bring into play drug effect, reaches the purpose of radical cure fish diseases.
The present invention is directed to the cause of disease of grass carp hemorrhage property disease generation and symptom feature occurs; Screen corresponding medicine and carry out symptomatic treatment; Radix Et Rhizoma Rhei in this compound preparation has eliminating fire and detoxication, bowel relieving relieving constipation, eliminating blood stasis and inducing menstruation effect; Staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery bacterium, multiple gram positive and negative property bacterium and various skin fungus all there are strong inhibitory action, also have antivirus action simultaneously; Fructus Mume is inhibited to various pathogens, can the enhancing human body immunity function; Galla Chinensis has the effect of resisting gram-positive bacteria and negative bacterium, and skin, mucosa, ulcer are had good astriction, and the his-and-hers watches dermophyte also has inhibitory action; Flos Daturae contains the hyoscyamine composition, has the neuroregulation effect, has pharmacological actions such as calcium antagonism, antioxidation, film protection and microcirculation improvement; Water peanut has the removing pathogenic heat from blood and toxic substance from the body effect; Leaf of Pterocarya Stenoptera has performances such as astringing to arrest bleeding, anti-inflammtory anti-dysentery, can suppress virus, and is also inhibited to pathogenic bacterium; Radix Glycyrrhizae has pharmacological actions such as detoxifcation, antiinflammatory, blood pressure lowering, analgesia, antiallergic action; Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping can be used for calmness, blood pressure lowering, antibiotic.The corresponding disease that this Chinese medicine formula can effectively be treated hemorrhagic disease of grass carp and supervened, noresidue has no side effect, and through clinical practice significant curative effect is arranged.
[specific embodiment]
Below in conjunction with specific embodiment the present invention is described further.
Embodiment 1
A kind of Chinese herbal compound preparation that is used to treat hemorrhagic disease of grass carp takes by weighing respectively from the crude drug that is selected from natural drying or 40～50 ℃ of oven dry: Radix Et Rhizoma Rhei 100g, Fructus Mume 40g, Galla Chinensis 50g; Flos Daturae 80g, water peanut 150g, leaf of Pterocarya Stenoptera 20g; Radix Glycyrrhizae 30g, Rhizoma Chuanxiong 30g pulverizes these raw materials through undue appearance; And cross 100 mesh sieves, the raw material after will pulverizing is then put into mixer, mixes promptly to get Chinese herbal compound preparation of the present invention in 10 minutes.
Embodiment 2
A kind of Chinese herbal compound preparation that is used to treat hemorrhagic disease of grass carp takes by weighing respectively from the crude drug that is selected from natural drying or 40～50 ℃ of oven dry: Radix Et Rhizoma Rhei 100g, Fructus Mume 100g, Galla Chinensis 50g; Flos Daturae 50g, water peanut 100g, leaf of Pterocarya Stenoptera 30g; Radix Glycyrrhizae 50g, Rhizoma Chuanxiong 20g pulverizes these raw materials through undue appearance; And cross 100 mesh sieves, the raw material after will pulverizing is then put into mixer, mixes promptly to get Chinese herbal compound preparation of the present invention in 10 minutes.
Embodiment 3
A kind of Chinese herbal compound preparation that is used to treat hemorrhagic disease of grass carp takes by weighing respectively from the crude drug that is selected from natural drying or 40～50 ℃ of oven dry: Radix Et Rhizoma Rhei 80g, Fructus Mume 100g, Galla Chinensis 50g; Flos Daturae 60g, water peanut 120g, leaf of Pterocarya Stenoptera 20g; Radix Glycyrrhizae 50g, Rhizoma Chuanxiong 20g pulverizes these raw materials through undue appearance; And cross 100 mesh sieves, the raw material after will pulverizing is then put into mixer, mixes promptly to get Chinese herbal compound preparation of the present invention in 10 minutes.
When adopting Chinese herbal compound preparation of the present invention to prevent and treat grass carp hemorrhage property disease and complication, as long as the dose foot is thrown something and fed and noted simultaneously regulating breeding environment, effective percentage can reach more than 95%, and cure rate reaches more than 70%.
Embodiment 4
The compliance test result test
(1) aquarium test:
1, test material
1.1 aquarium
Select 7 circulation aquariums, remove contamination with siphonage in the test, 25～30 ℃ of water temperatures, PH7～7.5.
1.2 fish challenge test
Buy grass carp hemorrhage virus GCHV from Chinese Academy of Sciences's aquatile institute, titre TCID50 is 3.5.When fish length is above to 2.5cm, begin to carry out counteracting toxic substances, stimulate the generation of hemorrhagic disease of grass carp.
1.3 pharmaceutical chemistry
Choose above-mentioned three groups of embodiment medicines, use 0.5kg medicine, 0.5kg Sal to process pharmaceutical chemistry by every 100kg fish.
2, test method:
2.1 the screening of sick fish
Choose each 30 tail of Ctenopharyngodon idellus of counteracting toxic substances morbidity, be respectively charged into number consecutively and be in 1～No. 7 the aquarium.Extraction is with the Ctenopharyngodon idellus of wholesale disease, and visual inspection fish body colour is turned black, and body surface is slightly congested.It is seriously congested to cut open the visible fish intestinal of inspection, and intestinal all is a cerise, mesentery, fat, the hyperemia of fish glue wall point-like, and the liver lighter color has a large amount of erythrocyte and the epithelial cell that comes off in the visible enteric cavity of microscopy.Laboratory diagnosis is that the disease fish is the enteritis type hemorrhagic disease of grass carp.
2.2 feeding experiment
With the feed of grass carp of 1 and 2 group, 3 and 4 groups, 5 and 6 groups interpolation embodiment 1,2,3 medicines of throwing something and feeding respectively, throw something and feed 7 groups of blank bait of contrast of throwing something and feeding, the young grass carps material 8610 that the Hai Wei Co., Ltd., Guangzhou City of feeding produces every day 2 times.
3, above each test group is all observed and is raised 20d, and record fish body is ingested and dead, survival.
4, result of the test: result of the test is seen table
Compare with matched group, behind the medicinal bait 3d of the present invention that feeds, begin to stop dead fish, especially embodiment 2, obviously reduce the 2nd day dead fish of feeding, and fish ingests to be increased to some extent.According to the data show of last table, use survival rate that medicine of the present invention can obviously improve hemorrhagic disease of grass carp more than 35～50%, especially embodiment 2, can improve the Ctenopharyngodon idellus survival rate and reach more than 80%, and effect is remarkable.
(2) pond medicine controlled trial
1, material
1.1 pond and sick fish
Choose 6 mouthfuls in the fish pond of outburst hemorrhagic disease of grass carp, the pond area is 8 mu, and the depth of water 1.5～1.8m is at the bottom of the pond about mud 40cm.Culvert system is complete, and 1 in 3kw aerator is equipped with in every pond, and the pond is main to support Ctenopharyngodon idellus, grow flower 20～30 of silver carps of cover.6 ponds are cultures the Ctenopharyngodon idellus marketable fish poud, about specification 0.4～0.6kg.
1.2 medicine
Choose medicine of the present invention and fully mix with feedstuff, set up test group, medicine matched group, blank group, experimental group is chosen medicine embodiment 2 drug regimens of the present invention, and prescription is formed and ratio is: Radix Et Rhizoma Rhei 100g; Fructus Mume 100g, Galla Chinensis 50g, Flos Daturae 50g, water peanut 100g; Leaf of Pterocarya Stenoptera 30g, Radix Glycyrrhizae 50g, Rhizoma Chuanxiong 20g pulverizes these raw materials through undue appearance; And cross 100 mesh sieves, the raw material after will pulverizing is then put into mixer, mixes promptly to get Chinese herbal compound preparation of the present invention in 10 minutes.
It is present market Chinese medicine composition " SANHUANGFEN "+Ramulus Et Folium Picrasmae commonly used that the medicine matched group is selected medicine for use, and its composition and ratio are: SANHUANG (Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei) 50%, Ramulus Et Folium Picrasmae 50%.
Experimental group and medicine matched group all mix bait feeding according to every 100kg fish with 0.5kg medicine, 0.5kg Sal.
The blank group is not added any medicine, the Ctenopharyngodon idellus adult fish material 8612 of selecting for use the Hai Wei Co., Ltd., Guangzhou City to produce.
2 methods
Selective examination morbidity Ctenopharyngodon idellus, visual inspection fish body is found blackout, cuts open the sick fish of inspection and finds the congested inflammation of intestinal,
6 morbidity ponds are divided into three groups of A, B, C, and every group is provided with 2 repetitions, use medicine embodiment of the present invention 2, medicine matched group, blank group to throw something and feed successively.
First discharge section pond Lao Shui before the medication, and the new water of annotating.Depth of water 1m, the pharmaceutical chemistry 2 times of throwing something and feeding every day, the pharmaceutical chemistry amount of throwing something and feeding every day is 2% of a pond fish weight, increases the aerator working time, the new water of regularly annotating.
3 therapeutic effect
Therapeutic effect sees following table for details:
Through evidence, use medicine of the present invention can alleviate the fish diseases symptom as early as possible, and final thoroughly recovery from illness.Compare with hemorrhagic disease medicine commonly used on the market, medicine instant effect of the present invention, the 5d that throws something and feeds promptly stops dead fish fully, and it is vigorous just to occur behind the 7d that throws something and feeds ingesting, the fireballing phenomenon of ingesting, effect is remarkable.
Claims (3)
1. Chinese herbal compound preparation that is used to treat hemorrhagic disease of grass carp is characterized in that its raw material is made up of the component of following parts by weight: Radix Et Rhizoma Rhei 80-100 part, Fructus Mume 40-100 part; Galla Chinensis 40-50 part; Leaf of Pterocarya Stenoptera 15-30 part, Radix Glycyrrhizae 30-50 part, water peanut 100-150 part; Flos Daturae 50-80 part, Rhizoma Chuanxiong 20-30 part.
2. the Chinese herbal compound preparation of treatment hemorrhagic disease of grass carp as claimed in claim 1 is characterized in that said each raw material is selected from the crude drug of natural drying or 40～50 ℃ of oven dry.
3. a method for preparing the Chinese herbal compound preparation of treating hemorrhagic disease of grass carp according to claim 1 is characterized in that said raw material is pulverized through undue appearance, and crosses 100 mesh sieves, and the raw material after will pulverizing is then put into mixer, mixes to get final product in 10 minutes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105631420A CN102028816B (en) | 2010-11-24 | 2010-11-24 | Chinese herbal medicinal compound preparation for treating hemorrhage disease of grass carp |
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| CN2010105631420A CN102028816B (en) | 2010-11-24 | 2010-11-24 | Chinese herbal medicinal compound preparation for treating hemorrhage disease of grass carp |
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| CN102028816B true CN102028816B (en) | 2012-03-28 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103655855B (en) * | 2012-09-24 | 2015-10-14 | 天津瑞贝特科技发展有限公司 | Chinese medicine composition for the treatment of research of hemorrhage of grass carp and preparation method thereof |
| CN103055047B (en) * | 2012-12-04 | 2014-12-10 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof |
| CN104189887A (en) * | 2014-07-30 | 2014-12-10 | 严中明 | Medicine for preventing and treating hemorrhagic diseases of grass carps |
| CN116942710A (en) * | 2023-06-16 | 2023-10-27 | 北京生泰尔科技股份有限公司 | Traditional Chinese medicine extract and application thereof in preparation of products for preventing, relieving or treating common fish virus diseases |
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| CN1091969A (en) * | 1993-03-10 | 1994-09-14 | 黄永培 | Compound drug for curing fish diseases |
| CN1102333A (en) * | 1993-11-04 | 1995-05-10 | 张素芳 | Medicine for fish |
| CN1099648A (en) * | 1994-05-27 | 1995-03-08 | 齐宝山 | Traditional Chinese medicine for curing bleeding disease and preparing method |
| CN1903280A (en) * | 2006-07-28 | 2007-01-31 | 河南农业大学 | Yukangsan herb medicine powder for treating fish diseases |
| CN101721512A (en) * | 2009-11-30 | 2010-06-09 | 常先苗 | Medicine for treating fishy fulminant hemorrhage |
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| 侯和菊.中草药与鱼病防治.《内陆水产》.2006,(第10期), * |
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