CN104383136A - Compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes and preparation method thereof - Google Patents
Compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes and preparation method thereof Download PDFInfo
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- CN104383136A CN104383136A CN201410741756.1A CN201410741756A CN104383136A CN 104383136 A CN104383136 A CN 104383136A CN 201410741756 A CN201410741756 A CN 201410741756A CN 104383136 A CN104383136 A CN 104383136A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- Natural Medicines & Medicinal Plants (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention relates to a compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes. The compound traditional Chinese medicine preparation is prepared from the following components: unprepared rehmannia roots, honeysuckles, fructus forsythiae, herba violae, figwort roots, rhubarbs, baikal skullcap roots and liquorice roots. The compound traditional Chinese medicine is prepared by the following steps: weighing the components in parts by weight, adding the components into a smasher respectively, smashing the components, sieving, mixing, and sieving. When in use, the compound traditional Chinese medicine is mixed with a feeder according to a certain proportion, and then a powdery bonding agent is added into the mixture of the compound traditional Chinese medicine and the feeder to form a medicinal bait. The medicinal bait needs to be aired before being fed to fishes. After the fishes are fed by the medicinal bait continuously for a period of time, the disease of the fishes can be controlled gradually, the appetite of the fishes can return to be normal, and the observation on the dissected fish shows that the upper jaw, lower jaw, oral cavity, branchial mantle, eyes and abdomen of the fish return to be normal, the color of the back of the fish becomes normal. The fishes fed by the preparation can grow well, no medicine is left, and side and toxic effects do not exist.
Description
Technical field
The invention belongs to fish bacterial septicemia treatment technology field, especially a kind ofly prevent and treat compound Chinese medicinal preparation of fish bacterial septicemia and preparation method thereof.
Background technology
The micro-Aeromonas hydrophila of cause of disease, Vibrio flurialis, Yersinia ruckeri etc. of fish bacterial septicemia, observe from pond, before death 1 ~ 2 day shoal of fish to rob food vigorous, floating sleep simultaneously, slowly travelling, occur rising and falling up and down, the fish anorexia be in a bad way or do not eat food, transfixion or paroxysmal occurs disorderly swim, run helter-skelter, have in pool side friction, last exhaustion is dead, observe from fish body, the upper lower jaw of the sick fish of main manifestations, oral cavity, the gill cover, eyes and fish body abdominal part mild hyperaemia, anus is red and swollen, the phenomenons such as fish body back blackening.Cut open in the visible intestinal of abdominal part and have a small amount of food.This plant disease epidemic is the widest, mortality rate is high, also has the features such as the kind endangering fish is many, the range of age is large, causes and serious loss to fish production.At present, mainly the chemicalses such as antibiotic are used to the control of this disease, but residual in fish body of consequent drug resistance and drug toxicity and medicine, cause preventing and curing of fish disease cost to improve, effect reduction, the health of the direct harm humans of disease.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of compound Chinese medicinal preparation of preventing and treating fish bacterial septicemia that scientific matching, therapeutic effect are good, have no side effect is provided.
The technical scheme that the present invention takes is:
Prevent and treat a compound Chinese medicinal preparation for fish bacterial septicemia, it is characterized in that: comprise the following component mixed by weight:
And, comprise the following component mixed by weight:
Another object of the present invention is to provide a kind of preparation method of preventing and treating the compound Chinese medicinal preparation of fish bacterial septicemia, it is characterized in that: comprise the following steps:
(1) take Radix Rehmanniae, Flos Lonicerae, Fructus Forsythiae, Herba Violae, Radix Scrophulariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Radix Glycyrrhizae by metering;
(2) each component is pulverized respectively through pulverizer, excessively blending after 80 mesh sieves;
(3) after 80 mesh sieves, obtain finished product.
Another object of the present invention is to provide a kind of using method of preventing and treating the compound Chinese medicinal preparation of fish bacterial septicemia, it is characterized in that: the medicament of claim 1 or 2 is mixed with feedstuff by the weight ratio of 3:10000, add the flour of the two gross weight 2%, the pharmaceutical chemistry made dries rear throwing something and feeding continuously 5 days.
Advantage of the present invention and good effect are:
In the present invention, take Radix Rehmanniae, Flos Lonicerae, Fructus Forsythiae, Herba Violae, Radix Scrophulariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Radix Glycyrrhizae by metering, add pulverizer respectively and pulverize, mutual blending after sieving, after sieve, obtain finished product.During use, mix with feedstuff by a certain percentage, make pharmaceutical chemistry after adding binding agent flour, dry and to throw something and feed a period of time continuously afterwards, the state of an illness is controlled gradually, the appetite of the shoal of fish recovers normal, observe lower jaw, oral cavity, the gill cover, eyes and fish body abdominal part after dissection to return to normal, fish body back color becomes normal color, shoal of fish well-grown after medication, drug residue free, has no side effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Prevent and treat a compound Chinese medicinal preparation for fish bacterial septicemia, innovation of the present invention is: comprise the following component mixed by weight:
Preferred scheme is: comprise the following component mixed by weight:
Each Chinese medicine all meets " Chinese veterinary pharmacopoeia " version two ministerial standard in 2010.Composition principle of the present invention is: Radix Rehmanniae clearing away heat and cooling blood; Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Fructus Forsythiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens; Herba Violae heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling; Radix Scrophulariae clearing away heat and cooling blood, eliminating fire and detoxication; Radix Et Rhizoma Rhei heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body; Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, hemostasis; Radix Glycyrrhizae invigorating the spleen and replenishing QI, regulating QI to relieve pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.All medicines share, antibacterial and detoxicating, the effects such as anti-inflammation hemostasia.
Embodiment 1
Prevent and treat a compound Chinese medicinal preparation for fish bacterial septicemia, Radix Rehmanniae 8 parts, Flos Lonicerae 8 parts, Fructus Forsythiae 7 parts, Herba Violae 7 parts, Radix Scrophulariae 5 parts, Radix Et Rhizoma Rhei 5 parts, Radix Scutellariae 5 parts, 4 parts, Radix Glycyrrhizae.
(1) take Radix Rehmanniae, Flos Lonicerae, Fructus Forsythiae, Herba Violae, Radix Scrophulariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Radix Glycyrrhizae by metering;
(2) each component is pulverized respectively through pulverizer, cross 80 mesh sieves (180 μm ± 7.6 μm) blending afterwards;
(3) after 80 mesh sieves (180 μm ± 7.6 μm), obtain finished product.
Embodiment 2
Prevent and treat a compound Chinese medicinal preparation for fish bacterial septicemia, Radix Rehmanniae 9 parts, Flos Lonicerae 9 parts, Fructus Forsythiae 7 parts, Herba Violae 7 parts, Radix Scrophulariae 6 parts, Radix Et Rhizoma Rhei 4 parts, Radix Scutellariae 4 parts, 1 part, Radix Glycyrrhizae
Be prepared by step in embodiment 1.
Embodiment 3
Prevent and treat a compound Chinese medicinal preparation for fish bacterial septicemia, Radix Rehmanniae 5 parts, Flos Lonicerae 5 parts, Fructus Forsythiae 4 parts, Herba Violae 4 parts, Radix Scrophulariae 4 parts, Radix Et Rhizoma Rhei 4 parts, Radix Scutellariae 2 parts, 2 parts, Radix Glycyrrhizae
Be prepared by step in embodiment 1.
Embodiment 4
Prevent and treat a compound Chinese medicinal preparation for fish bacterial septicemia, Radix Rehmanniae 6 parts, Flos Lonicerae 6 parts, Fructus Forsythiae 5 parts, Herba Violae 5 parts, Radix Scrophulariae 4 parts, Radix Et Rhizoma Rhei 3 parts, Radix Scutellariae 3 parts, 3 parts, Radix Glycyrrhizae
Be prepared by step in embodiment 1.
Clinical trial:
Administering mode: admix fish-bait feedstuff, 3g, every 1Kg feedstuff, the flour adding 2% makes pharmaceutical chemistry as binding agent, dries.
In August, 2012, the dead 15 tail fishes in fish pond, Tianjin, observe from limit, pond, and it is vigorous that the shoal of fish robs food, simultaneously the floating water surface, slowly travelling, occur rising and falling up and down.Analyse in the visible intestinal of dead fish and have a small amount of food, the upper lower jaw of sick fish, oral cavity, the gill cover, eyes and fish body abdominal part mild hyperaemia, anus is red and swollen, and the phenomenons such as fish body back blackening, are diagnosed as bacterial septicemia, then uses embodiment 2 medicine.Medication is after 1 day, and fish pond continues to occur dead fish, and medication, after 3 days, does not continue dead fish, and after using 5 days continuously, shoal of fish appetite recovers normal, fingerling well-grown.
In the present invention, take Radix Rehmanniae, Flos Lonicerae, Fructus Forsythiae, Herba Violae, Radix Scrophulariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Radix Glycyrrhizae by metering, add pulverizer respectively and pulverize, mutual blending after sieving, after sieve, obtain finished product.During use, mix with feedstuff by a certain percentage, make pharmaceutical chemistry after adding binding agent flour, dry and to throw something and feed a period of time continuously afterwards, the state of an illness is controlled gradually, the appetite of the shoal of fish recovers normal, observe lower jaw, oral cavity, the gill cover, eyes and fish body abdominal part after dissection to return to normal, fish body back color becomes normal color, shoal of fish well-grown after medication, drug residue free, has no side effect.
Claims (4)
1. prevent and treat a compound Chinese medicinal preparation for fish bacterial septicemia, it is characterized in that: comprise the following component mixed by weight:
2. a kind of compound Chinese medicinal preparation of preventing and treating fish bacterial septicemia according to claim 1, is characterized in that: comprise the following component mixed by weight:
3. a kind of preparation method of preventing and treating the compound Chinese medicinal preparation of fish bacterial septicemia according to claim 1 and 2, is characterized in that: comprise the following steps:
(1) take Radix Rehmanniae, Flos Lonicerae, Fructus Forsythiae, Herba Violae, Radix Scrophulariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Radix Glycyrrhizae by metering;
(2) each component is pulverized respectively through pulverizer, excessively blending after 80 mesh sieves;
(3) after 80 mesh sieves, obtain finished product.
4. prevent and treat the using method of the compound Chinese medicinal preparation of fish bacterial septicemia for one kind, it is characterized in that: the medicament of claim 1 or 2 is mixed with feedstuff by the weight ratio of 3:10000, add the flour of the two gross weight 2%, the pharmaceutical chemistry made dries rear throwing something and feeding continuously 5 days.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410741756.1A CN104383136A (en) | 2014-12-08 | 2014-12-08 | Compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes and preparation method thereof |
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| CN201410741756.1A CN104383136A (en) | 2014-12-08 | 2014-12-08 | Compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194086A (en) * | 2015-10-18 | 2015-12-30 | 杨成胜 | Traditional Chinese medicine composition for preventing bacterial hemorrhagic disease of megalobrama amblycephala |
| CN105434706A (en) * | 2016-01-18 | 2016-03-30 | 张嗣喜 | Traditional Chinese medicine composition for treating gill rote disease of fish |
| CN107320637A (en) * | 2017-08-04 | 2017-11-07 | 安徽省泾县丰瑞水产科技有限公司 | A kind of Chinese herbal medicine for treating septicemia of sturgeon |
| CN107412417A (en) * | 2017-04-20 | 2017-12-01 | 安徽省农业科学院水产研究所 | A kind of Chinese herbal formula and method for preventing channel catfish enteric septicemia |
| CN109010497A (en) * | 2018-10-29 | 2018-12-18 | 河南后羿实业集团有限公司 | It is a kind of for treating the drug and preparation method thereof of fish bacterial septicemia and enteritis |
| CN112675208A (en) * | 2020-12-31 | 2021-04-20 | 西藏自治区农牧科学院水产科学研究所 | Premixed preparation for preventing and treating septicemia of Leptospira bifidus and preparation method thereof |
-
2014
- 2014-12-08 CN CN201410741756.1A patent/CN104383136A/en active Pending
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194086A (en) * | 2015-10-18 | 2015-12-30 | 杨成胜 | Traditional Chinese medicine composition for preventing bacterial hemorrhagic disease of megalobrama amblycephala |
| CN105434706A (en) * | 2016-01-18 | 2016-03-30 | 张嗣喜 | Traditional Chinese medicine composition for treating gill rote disease of fish |
| CN107412417A (en) * | 2017-04-20 | 2017-12-01 | 安徽省农业科学院水产研究所 | A kind of Chinese herbal formula and method for preventing channel catfish enteric septicemia |
| CN107320637A (en) * | 2017-08-04 | 2017-11-07 | 安徽省泾县丰瑞水产科技有限公司 | A kind of Chinese herbal medicine for treating septicemia of sturgeon |
| CN109010497A (en) * | 2018-10-29 | 2018-12-18 | 河南后羿实业集团有限公司 | It is a kind of for treating the drug and preparation method thereof of fish bacterial septicemia and enteritis |
| CN112675208A (en) * | 2020-12-31 | 2021-04-20 | 西藏自治区农牧科学院水产科学研究所 | Premixed preparation for preventing and treating septicemia of Leptospira bifidus and preparation method thereof |
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Application publication date: 20150304 |