CN109568461B - Traditional Chinese medicine composition for treating damp-heat dysentery of pets and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for treating damp-heat dysentery of pets and preparation method and application thereof Download PDF

Info

Publication number
CN109568461B
CN109568461B CN201811581915.0A CN201811581915A CN109568461B CN 109568461 B CN109568461 B CN 109568461B CN 201811581915 A CN201811581915 A CN 201811581915A CN 109568461 B CN109568461 B CN 109568461B
Authority
CN
China
Prior art keywords
parts
chinese medicine
traditional chinese
preparation
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201811581915.0A
Other languages
Chinese (zh)
Other versions
CN109568461A (en
Inventor
范开
王帅玉
林珈好
管治斌
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
China Agricultural University
Original Assignee
China Agricultural University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by China Agricultural University filed Critical China Agricultural University
Priority to CN201811581915.0A priority Critical patent/CN109568461B/en
Publication of CN109568461A publication Critical patent/CN109568461A/en
Application granted granted Critical
Publication of CN109568461B publication Critical patent/CN109568461B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a traditional Chinese medicine composition for treating damp-heat dysentery of pets, and a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight: 20-80 parts of rhubarb, 20-80 parts of immature bitter orange, 20-80 parts of officinal magnolia bark, 20-80 parts of green tangerine peel, 20-80 parts of costustoot, 10-60 parts of betel nut, 20-80 parts of coptis root, 20-80 parts of baical skullcap root, 50-200 parts of Chinese magnoliavine fruit and 20-80 parts of liquoric root; the dosage form is tablet, capsule, powder or pill; the preparation method comprises pulverizing the raw materials respectively, mixing, and making into various dosage forms. The immature bitter orange, the mangnolia officinalis, the green tangerine orange peel, the betel nut and the elecampane in the traditional Chinese medicine composition promote gastrointestinal peristalsis and accelerate discharge of accumulated substances, the dosage of the rheum officinale is small, the rheum officinale mildly stimulates intestinal peristalsis and achieves the effects of cooling blood and dissipating blood stasis, after the accumulated substances are discharged, irritation factors in intestinal tracts are greatly reduced, vomiting reaction is relieved, the treatment effect is good, and the practical popularization value is important.

Description

Traditional Chinese medicine composition for treating damp-heat dysentery of pets and preparation method and application thereof
Technical Field
The invention belongs to the technical field of veterinary traditional Chinese medicines, relates to the technical field of treatment of damp-heat dysentery of pets, and particularly relates to a traditional Chinese medicine composition for treating damp-heat dysentery of pets, and a preparation method and application thereof.
Background
In the life of pets, the pet often smells, licks and picks up foreign matters, or causes the digestive tract problems of vomiting, diarrhea and the like due to unclean diet. The common symptom is diarrhea, or vomiting first and then diarrhea; the defecation is thin, smelly, sticky and greasy, and often mixed with jelly-like mucus, with occasional occurrence of dirty, smelly, bloody and stool. The disease is more sudden, the course of the disease is generally not long time, the symptoms are characterized by red tongue, powerful pulse and vomiting and diarrhea with foul odor, and the disease belongs to the category of damp-heat dysentery of Chinese veterinarians. In addition, enteritis caused by other reasons, such as canine parvovirus enteritis, is also commonly manifested as damp-heat dysentery in the early stage.
At present, western veterinary medicine for treating damp-heat dysentery mainly treats vomiting, diarrhea and bacteria. Antibacterial is a valuable therapeutic direction; vomiting and diarrhea is a protective reaction after the digestive tract is contacted with harmful substances, and if the harmful substances in the digestive tract are cleared away, the vomiting and diarrhea can be stopped by oneself, so that the vomiting and diarrhea are not always stopped or the diarrhea is stopped when the vomiting and the diarrhea are not very serious but the physical condition is still good. The existing western veterinary treatment has no effective way for promoting the discharge of harmful substances in the intestinal tract.
In digestive tract diseases such as dysentery, if the intestinal deposits are not cleared in time, the intestinal deposits can be fermented continuously to generate a large amount of harmful products, and after absorption, the intestinal deposits can have great adverse effects on the whole body state. The traditional Chinese veterinary medicine for treating damp-heat dysentery has a famous rule that the general cause is common-since diarrhea is a way for expelling harmful substances, the treatment should promote the harmful substances to be expelled as soon as possible. However, at present, Chinese veterinarian treatment for damp-heat dysentery mainly adopts pulsatilla chinensis decoction, which is a medicine for clearing heat, eliminating dampness and astringing. These drugs, while controlling the inflammatory response of the intestinal tract, also have no effect of promoting the excretion of harmful substances from the intestinal tract.
Therefore, it is necessary to research and develop a traditional Chinese medicine composition for treating damp-heat dysentery of pets, which adopts a general-purpose treatment rule of general reasons, promotes sick pets to discharge accumulated matters in intestinal tracts as soon as possible, and is matched with medicines for promoting blood circulation to remove blood stasis and dissipating enteritis.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating damp-heat dysentery of pets, which focuses on promoting the discharge of the accumulated materials in the digestive tract.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating damp-heat dysentery of pets.
The invention also aims to provide application of the traditional Chinese medicine composition for treating damp-heat dysentery of pets.
The purpose of the invention is realized by the following technical scheme:
a traditional Chinese medicine composition for treating damp-heat dysentery of pets comprises the following traditional Chinese medicine components:
rhubarb, immature bitter orange, officinal magnolia bark, green tangerine peel, costustoot, areca seed, golden thread, baical skullcap root, Chinese magnoliavine fruit and liquoric root.
Wherein, rhubarb clears heat and purges fire, purges accumulation and removes stagnation, and activates blood circulation to dissipate blood stasis.
Wherein, the coptis and the scutellaria have the effects of clearing heat and purging fire, and being bitter and cold and drying dampness.
Wherein, the immature bitter orange, the officinal magnolia bark, the green tangerine peel, the betel nut and the costustoot have the functions of eliminating dampness, regulating qi and relaxing bowels.
The combination has the symptoms of diarrhea and qi consumption, and the bitter and dry herbs in the prescription have the symptom of yin impairment, so the liquorice tonifies qi and harmonizes the herbs, and the schisandra chinensis is sour and sweet to transform yin, so the bias of the aromatic and dry herbs is restricted.
In the technical scheme, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:
20-80 parts of rhubarb, 20-80 parts of immature bitter orange, 20-80 parts of officinal magnolia bark, 20-80 parts of green tangerine peel, 20-80 parts of costustoot, 10-60 parts of betel nut, 20-80 parts of coptis root, 20-80 parts of baical skullcap root, 50-200 parts of Chinese magnoliavine fruit and 20-80 parts of liquoric root.
Further, in the technical scheme, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:
60-78 parts of rheum officinale, 58-72 parts of immature bitter orange, 50-64 parts of mangnolia officinalis, 62-74 parts of green tangerine peel, 52-65 parts of costustoot, 42-54 parts of betel nut, 47.5-64 parts of coptis chinensis, 55-64 parts of scutellaria baicalensis, 78-124 parts of schisandra chinensis and 54-65 parts of liquorice.
Still further, in the above technical scheme, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:
72 parts of rhubarb, 66 parts of immature bitter orange, 58 parts of officinal magnolia bark, 68.5 parts of green tangerine peel, 57 parts of costustoot, 48.7 parts of areca seed, 57.4 parts of coptis root, 61.4 parts of baical skullcap root, 98.6 parts of Chinese magnoliavine fruit and 58.8 parts of liquoric root.
Still further, in the above technical scheme, the dosage form of the Chinese medicinal composition is one of oral preparations such as tablets, capsules, powders and pills.
The invention provides a preparation method of a traditional Chinese medicine composition, the dosage form of the traditional Chinese medicine composition is pills, and the preparation method comprises the steps of weighing all traditional Chinese medicine components according to the formula amount, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, adding refined honey to prepare small honeyed pills, drying, polishing and bagging to obtain the traditional Chinese medicine composition.
In the technical scheme, 150g of refined honey is added into 100g of the composite traditional Chinese medicine powder to prepare small honeyed pills, and each pill is 2 g.
The invention provides a preparation method of a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition is in a tablet form, and the preparation method comprises the steps of weighing traditional Chinese medicine components according to formula amount, respectively crushing the traditional Chinese medicine components, sieving the traditional Chinese medicine components by a 100-mesh sieve, uniformly mixing the traditional Chinese medicine components to obtain composite traditional Chinese medicine powder, adding auxiliary materials, tabletting and coating.
The invention provides a preparation method of the traditional Chinese medicine composition, the dosage form of the traditional Chinese medicine composition is capsules, and the preparation method comprises the steps of weighing the traditional Chinese medicine components according to the formula amount, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, adding auxiliary materials, uniformly mixing and encapsulating.
The invention also provides application of the traditional Chinese medicine composition in preparation of veterinary medicines for treating damp-heat dysentery of pets.
The traditional Chinese medicine composition for treating damp-heat dysentery of pets has the following advantages:
(1) in the traditional Chinese medicine composition for treating damp-heat dysentery of pets, the immature bitter orange, the mangnolia officinalis, the green tangerine orange peel, the betel nut, the costustoot and the like promote gastrointestinal peristalsis and accelerate discharge of accumulated substances, but diarrhea aggravation is not caused due to aromatic dampness drying, the using amount of the rhubarb is small, on one hand, intestinal peristalsis is stimulated mildly, on the other hand, the effects of cooling blood and dissipating stasis are achieved, enteritis is dissipated, the effects of clearing heat and activating blood are taken as the main effects, and congestion and bleeding of intestinal tracts are controlled;
(2) in the traditional Chinese medicine composition for treating damp-heat dysentery of pets, after accumulated materials are discharged, irritation factors in intestinal tracts are greatly reduced, diarrhea can be stopped by oneself, stomach emptying is facilitated, and vomiting reaction is also facilitated to be relieved;
(3) the traditional Chinese medicine composition for treating damp-heat dysentery of pets, provided by the invention, is prepared by respectively crushing and mixing the raw material medicines of each component, and then preparing the raw material medicines into various dosage forms, has the advantages of simple required conditions and equipment and simple and controllable process, and can effectively promote the discharge of the accumulated materials in the digestive tract, thereby being beneficial to the treatment of damp-heat dysentery of pets and having very important practical popularization value.
Detailed Description
The following describes the embodiments of the present invention in further detail with reference to specific examples.
The following examples are intended only to further illustrate the present invention and should not be construed as limiting the invention. Modifications or substitutions to methods, procedures, or conditions of the invention may be made without departing from the spirit and scope of the invention.
The raw material sources used in the examples of the invention and the comparative examples are as follows:
the herbal medicines used in the examples and comparative examples of the present invention are all commercially available products.
Unless otherwise specified, the technical means used in the examples of the present invention are conventional means well known to those skilled in the art.
Example 1A Chinese medicinal composition for treating damp-heat dysentery of pets
1. The raw material ratio is as follows:
68 parts of rhubarb, 62 parts of immature bitter orange, 56 parts of officinal magnolia bark, 65 parts of green tangerine peel, 57 parts of costustoot, 46.5 parts of areca seed, 54 parts of coptis root, 58 parts of baical skullcap root, 98 parts of Chinese magnoliavine fruit and 60 parts of liquoric root;
2. the preparation method comprises the following steps:
respectively weighing rhubarb, immature bitter orange, magnolia officinalis, green tangerine orange peel, costustoot, areca nut, coptis chinensis, scutellaria baicalensis, schisandra chinensis and liquorice according to the formula amount, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, then adding a coating agent, an adhesive and the like into the composite traditional Chinese medicine powder, uniformly mixing, and pressing into tablets, wherein each tablet contains 0.45g of the composite traditional Chinese medicine powder.
Example 2A Chinese medicinal composition for treating damp-heat dysentery of pets
1. The raw material ratio is as follows:
48 parts of rhubarb, 64 parts of immature bitter orange, 72 parts of officinal magnolia bark, 66 parts of green tangerine peel, 59 parts of costustoot, 50 parts of areca seed, 42 parts of coptis root, 52.5 parts of baical skullcap root, 148 parts of Chinese magnoliavine fruit and 48 parts of liquoric root.
2. The preparation method comprises the following steps:
respectively weighing rhubarb, immature bitter orange, magnolia officinalis, green tangerine orange peel, costustoot, areca nut, coptis chinensis, scutellaria baicalensis, schisandra chinensis and liquorice according to the formula amount, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, then adding a forming agent into the composite traditional Chinese medicine powder, uniformly mixing, preparing into granules, and filling into capsules, wherein each capsule contains 0.4g of the composite traditional Chinese medicine powder.
Example 3A Chinese medicinal composition for treating damp-heat dysentery of pets
1. The raw material ratio is as follows:
72 parts of rhubarb, 66 parts of immature bitter orange, 58 parts of officinal magnolia bark, 68.5 parts of green tangerine peel, 57 parts of costustoot, 48.7 parts of areca seed, 57.4 parts of coptis root, 61.4 parts of baical skullcap root, 98.6 parts of Chinese magnoliavine fruit and 58.8 parts of liquoric root;
2. the preparation method comprises the following steps:
weighing rhubarb, immature bitter orange, magnolia officinalis, green tangerine orange peel, costustoot, areca nut, coptis chinensis, scutellaria baicalensis, schisandra chinensis and liquorice according to the formula amount, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, then adding 140g of refined honey into every 100g of the composite traditional Chinese medicine powder, and preparing into small honeyed pills, wherein each pill contains 0.9g of the composite traditional Chinese medicine powder.
Comparative example 1A traditional Chinese medicine composition for treating damp-heat dysentery of pets
1. The raw material ratio is as follows:
66 parts of immature bitter orange, 58 parts of officinal magnolia bark, 68.5 parts of green tangerine peel, 57 parts of costustoot, 48.7 parts of areca nut, 57.4 parts of coptis root, 61.4 parts of baical skullcap root, 98.6 parts of Chinese magnoliavine fruit and 58.8 parts of liquoric root;
2. the preparation method comprises the following steps:
weighing fructus Aurantii Immaturus, cortex Magnolia officinalis, pericarpium Citri Reticulatae viride, radix aucklandiae, Arecae semen, Coptidis rhizoma, Scutellariae radix, fructus Schisandrae and Glycyrrhrizae radix according to formula amount, respectively pulverizing, sieving with 100 mesh sieve, mixing well to obtain composite Chinese medicinal powder, adding Mel 125g per 100g of composite Chinese medicinal powder, and making into honeyed pill with composite Chinese medicinal powder 0.9g per pill.
Comparative example 2 traditional Chinese medicine composition for treating damp-heat dysentery of pets
1. The raw material ratio is as follows:
66 parts of rhubarb, 64 parts of immature bitter orange, 59 parts of officinal magnolia bark, 70 parts of green tangerine peel, 57 parts of costustoot, 49.5 parts of areca seed, 12 parts of coptis root, 106 parts of baical skullcap root, 108 parts of Chinese magnoliavine fruit and 60 parts of liquoric root;
2. the preparation method comprises the following steps:
respectively weighing rhubarb, immature bitter orange, magnolia officinalis, green tangerine orange peel, costustoot, areca nut, coptis chinensis, scutellaria baicalensis, schisandra chinensis and liquorice according to the formula amount, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, then adding a coating agent, an adhesive and the like into the composite traditional Chinese medicine powder, uniformly mixing, and pressing into tablets, wherein each tablet contains 0.45g of the composite traditional Chinese medicine powder.
Comparative example 3 traditional Chinese medicine composition for treating damp-heat dysentery of pets
1. The raw material ratio is as follows:
58 parts of rhubarb, 76 parts of immature bitter orange, 80 parts of officinal magnolia bark, 76 parts of green tangerine peel, 69 parts of costustoot, 42 parts of coptis root, 52.5 parts of baical skullcap root, 148 parts of Chinese magnoliavine fruit and 48 parts of liquoric root.
2. The preparation method comprises the following steps:
respectively weighing rhubarb, immature bitter orange, magnolia officinalis, green tangerine orange peel, costustoot, areca nut, coptis chinensis, scutellaria baicalensis, schisandra chinensis and liquorice according to the formula amount, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, then adding a forming agent into the composite traditional Chinese medicine powder, uniformly mixing, preparing into granules, and filling into capsules, wherein each capsule contains 0.4g of the composite traditional Chinese medicine powder.
And (3) comparing test effects:
1. data relating to comparative tests
Case inclusion criteria: selecting a naturally-occurring sick dog and a sick cat suffering from damp-heat dysentery as verification objects, wherein the specific symptoms are as follows: early mental deterioration, loss or abolition of appetite, dryness of the nasoscope, and sometimes elevated body temperature; diarrhea, even bloody stool, brick red, soy sauce color and bright red stool, foul smell of the stool and vomit; the phenomenon of dehydration gradually occurs, the elasticity of the skin decreases, and wrinkles disappear slowly when the skin is pinched. The patients who are treated by the conventional antibacterial and hemostatic therapy (oral administration such as gentamicin, subcutaneous injection of quininone and the like; subcutaneous injection of hemostatic drugs such as etamsylate and the like) for more than 7 days are ineffective and can be treated by experimental treatment.
Criteria for judgment of cure or ineffectiveness: diarrhea completely stops or normal formed feces are excreted, appetite is recovered to be above 1/2 of normal appetite, and mental state is obviously improved. After continuous administration for more than 7 days, loose stool is still seen, and the patients with no improvement or continuous deterioration of spirit and appetite are ineffective.
2. Test method
64 dogs and 16 cats meeting the above criteria were randomized into 8 groups of 8 dogs and 2 cats.
The test groups 1 to 3 were treated with the Chinese medicinal composition preparations of examples 1 to 3, the test groups 4 to 6 were treated with the Chinese medicinal composition preparations of comparative examples 1 to 3, the test group 7 was treated with conventional antibiotics and antiviral drugs, and the test group 8 was a comparative blank test without treatment.
The dosage is controlled such that the weight of the Chinese medicinal composition contained in the preparation is 0.9g per 10kg of body weight, and the administration is carried out 2 times per day.
3. Test results
The results of the above clinical trial treatments are shown in table 1 below.
TABLE 1 comparison of results of clinical trial treatments for each group
The results in table 1 show that the average cure rate of the traditional Chinese medicine composition preparation for treating damp-heat dysentery of pets can reach more than 70 percent (the highest cure rate can reach more than 90 percent), is obviously higher than the treatment effect (cure rate of 60 percent) of the conventional antibiotics and antiviral drugs, and the corresponding medication course is shorter than that of the conventional antibiotics and antiviral drugs.
Typical cases are:
case 1
Tady dog, male, 2 years old, body weight 4kg, already immunized. Vomiting in the early morning 3 days ago, and the vomit is the dog food taken in the early night and has yellow sticky mucus and sour and smelly smell; diarrhea is observed in the afternoon of the day, the excrement is pasty, and the feeding owner uses the berberine by himself, so the effect is not achieved. On the 3 rd day after vomiting and diarrhea, vomiting stopped, but the feces became loose, sticky and greasy, and there was jelly egg white-like mucus in the feces, which was bad in smell, non-appetizing, refreshing, poor in skin elasticity, reddish in tongue, and strong and forceful in pulse, and met the judgment standard of damp-heat dysentery.
After the pill of the invention in the embodiment 3 is taken, the times of defecation increase from afternoon to evening, the foul smell is discharged, the sticky and greasy defecation is discharged, and the appetite begins to recover in the evening; when the medicine is taken for 2 times a day, the feces begin to form the next day; on day 3, the symptoms completely disappeared and the medication was stopped on day 3. After 1 week of follow-up visit, the state of the stool and urine was good.
In this case, berberine taken by the owner of the feed is related to coptis chinensis and scutellaria baicalensis in the invention, but the effect is not ideal because the berberine is lack of medicines for promoting the discharge of intestinal accumulated materials. After the medicine of the present invention is used, harmful deposited matter is exhausted out of body and thus the medicine can recover fast.
Case 2
Labrador retriever, male, 3 months old, 2kg body weight, unclear immune status. After the feed is purchased for 4 days, vomiting occurs, the appetite is poor, and diarrhea is not seen. The parvovirus is detected to be positive. The dog has a reasonable mental state, reddish tongue and hyperdynamic pulse, and although diarrhea is not seen, the dog conforms to the standard of damp-heat dysentery according to clinical symptoms and the development rule of canine parvovirus. The principal of the feed is not enough, so the feed can not be used for treatment of fluid infusion, virus resistance and the like. The pill of example 3 of the present invention was taken with a 30% glucose solution by itself, with the order of stopping eating for 1 day.
The next day of administration, the foul and loose stool is discharged for 3 times, and the foul smell of the stool becomes lighter as the defecation times increase. On day 3, no defecation was observed, appetite was restored, and a small amount of food was ordered. No defecation is seen on day 4, and the appetite is further improved compared with yesterday. The diet II on day 5 was substantially normal.
The disease is not developed soon, but the condition is still acceptable. The parvovirus has foul bloody stool in the later stage, and although defecation is not seen in the initial stage, accumulation in the intestinal tract is judged by the red tongue and the hyperfunction of pulse force, and if the enterovirus is not discharged in time, the toxin can affect the general state after being absorbed. Therefore, even though diarrhea is not seen, the medicine of the invention can be used to achieve the effects of clearing intestine, expelling toxin and preventing diseases and transformation.
Case 3
Golden retriever, male, 3 years old, body weight 30 kg. The habit of picking up food and sundries is always kept. The diarrhea suddenly happens in the morning and evening, red-brown thin bloody stool is sprayed, the smell is fishy, the spirit is normal, the appetite is obviously reduced, and the vomiting is not seen. No obvious foreign body is seen in the abdomen palpation. Through laboratory detection, pancreatic lipase is abnormal, the total number of white blood cells is obviously increased, and pancreatitis is diagnosed. The dog has normal tongue color, and a strong and forceful pulse with a high pulsation. The patients with the disease have excessive pulse force, which indicates that the bloody stool is an excessive syndrome, and meets the damp-heat dysentery standard, and the methods of catharsis and blood circulation can be used; although oral administration is generally not suitable for pancreatitis cases, the patient dog had no vomiting and had a small appetite, and the tablet of example 1 of the present invention was administered. When a feeding owner is ordered to take the oral administration, the tablet of the invention is hydrated into paste by sugar, and the paste is frequently fed by a small amount of a straw, so that the sick dog can accept the oral administration without vomit. In other treatment aspects, the breeder agrees to eat for 1-2 days, during which time a 30% glucose solution is consumed.
The next day after the medicine is taken, the sick dog begins to discharge black sticky excrement, and the fishy smell is reduced; on day 3, no bowel movement occurred and the breeder started to feed the food with dietary preference. On day 5 of administration, feces with normal morphology and color began to be excreted. After the medicine is taken for 5 days, the medicine is stopped, and the state is normal. After 2 weeks of follow-up, the appetite gradually recovered and no abnormality was observed.
Case 4
Female of China garden cat, 3 years old, 3.5kg body weight, without any artificial immunity. The pet can escape from the house when the owner lives on the 1 st floor of the building. Escape before the last week, poor appetite after coming back, occasional vomiting and foul vomiting, and no food intake at all and no defecation before yesterday. The body temperature was measured at 40.3 ℃ at the time of admission, and the feline panleukosis virus was positive. According to clinical manifestations, the intestinal tract is analyzed to have loose stool, but the stool is not discharged yet, and the standard of damp-heat dysentery is met. Generally, cats are not easy to accept oral administration, but the sex of the cats is warm and domesticated, the relation with the breeder is good, and the breeder is unable to pay the expenses of antiviral drugs and fluid infusion. Thus, administration of the bolus of example 3 of the invention ordered the bolus to be a paste in dextrose water, fed drop-on, and given a small number of times an oral rehydration salt in combination with a hypertonic dextrose solution to supplement energy.
After 2 days of administration, the cats discharged a small amount of sticky feces and included a small amount of jelly-like mucus 3 times (confirming that the damp-heat dysentery was indeed met); and appetite begins to appear, after which it gradually increases. No defecation was observed 2 days later. By the 4 th day of administration, the appetite reached half of the normal appetite. On day 5, the spirit and appetite were substantially restored.
Case 5
Autumn dog, male, 5 years old, body weight 23 kg. In the last 1 year, diarrhea attacks have occurred, each time associated with the feeding of meat. When the disease occurs, the disease is tenesmus, a large amount of intestinal mucosa falls off in mucus and stool, the odor does not cause foul odor, but is different from the odor of normal feces, and the disease meets the damp-heat dysentery standard. In the conventional treatment, the dilution lasts for 4 to 7 days every time the cephalosporin or quinuclidinone antibiotics are used. The dog has reddish tongue color and normal pulse strength. Considering that it has repeated attacks of diarrhea for a long time and is related to the feeding of high-protein and high-fat food, it is judged that it should have spleen deficiency but is stimulated by bad food, and the attack shows an excess syndrome. Therefore, in case of onset, excess should be reduced first and then deficiency should be reinforced. The pill of the invention in the embodiment 3 can stop diarrhea after being taken for 2 days, and has obvious and quick curative effect compared with the common treatment. The general purpose drugs for general reasons are used to injure the body resistance, and the administration is stopped in 3 days. Then gradually taking tonification and medication for 1 week, and then taking qi-tonifying and spleen-invigorating medication for 2 weeks. After half a year of follow-up, the diet and the stool are normal, and the secondary attack is not seen.
Finally, the above is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (9)

1. A traditional Chinese medicine composition for treating damp-heat dysentery of pets,
the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:
20-80 parts of rhubarb, 20-80 parts of immature bitter orange, 20-80 parts of officinal magnolia bark, 20-80 parts of green tangerine peel, 20-80 parts of costustoot, 10-60 parts of betel nut, 20-80 parts of coptis root, 20-80 parts of baical skullcap root, 50-200 parts of Chinese magnoliavine fruit and 20-80 parts of liquoric root.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:
60-78 parts of rheum officinale, 58-72 parts of immature bitter orange, 50-64 parts of mangnolia officinalis, 62-74 parts of green tangerine peel, 52-65 parts of costustoot, 42-54 parts of betel nut, 47.5-64 parts of coptis chinensis, 55-64 parts of scutellaria baicalensis, 78-124 parts of schisandra chinensis and 54-65 parts of liquorice.
3. The traditional Chinese medicine composition according to claim 2, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:
72 parts of rhubarb, 66 parts of immature bitter orange, 58 parts of officinal magnolia bark, 68.5 parts of green tangerine peel, 57 parts of costustoot, 48.7 parts of areca seed, 57.4 parts of coptis root, 61.4 parts of baical skullcap root, 98.6 parts of Chinese magnoliavine fruit and 58.8 parts of liquoric root.
4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the dosage form of the Chinese medicinal composition is one of tablets, capsules, powders and pills.
5. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 4,
the preparation method comprises weighing the traditional Chinese medicine components according to the formula amount, respectively crushing, sieving with a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, adding refined honey to prepare into small honeyed pills, drying, polishing and bagging.
6. The preparation method according to claim 5, wherein the compound Chinese medicinal powder is prepared into honeyed pills by adding 150g of refined honey into 100g of the compound Chinese medicinal powder, wherein each pill contains 0.9g of the compound Chinese medicinal powder.
7. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 4,
the preparation method comprises the steps of weighing the traditional Chinese medicine components according to the formula amount, respectively crushing, sieving with a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, adding auxiliary materials, tabletting and coating.
8. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 4,
the preparation method comprises the steps of weighing the traditional Chinese medicine components according to the formula amount, respectively crushing, sieving by a 100-mesh sieve, uniformly mixing to obtain composite traditional Chinese medicine powder, adding auxiliary materials, uniformly mixing and encapsulating.
9. Use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of veterinary drugs for treating damp-heat dysentery of pets.
CN201811581915.0A 2018-12-24 2018-12-24 Traditional Chinese medicine composition for treating damp-heat dysentery of pets and preparation method and application thereof Active CN109568461B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811581915.0A CN109568461B (en) 2018-12-24 2018-12-24 Traditional Chinese medicine composition for treating damp-heat dysentery of pets and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811581915.0A CN109568461B (en) 2018-12-24 2018-12-24 Traditional Chinese medicine composition for treating damp-heat dysentery of pets and preparation method and application thereof

Publications (2)

Publication Number Publication Date
CN109568461A CN109568461A (en) 2019-04-05
CN109568461B true CN109568461B (en) 2021-07-13

Family

ID=65930963

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811581915.0A Active CN109568461B (en) 2018-12-24 2018-12-24 Traditional Chinese medicine composition for treating damp-heat dysentery of pets and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN109568461B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1569170A (en) * 2004-05-11 2005-01-26 杨家亮 Hog cholera treating medicine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1569170A (en) * 2004-05-11 2005-01-26 杨家亮 Hog cholera treating medicine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
反治法在兽医临床应用的探讨;张德民等;《中兽医医药杂志》;19971231(第5期);第34页第2.4节 *
犬痢疾治验一例;崔效成;《中兽医医药杂志》;19881231(第3期);第31页 *
羔羊痢疾的防治;李勇生;《畜牧兽医科技信息》;20041130;第32页 *

Also Published As

Publication number Publication date
CN109568461A (en) 2019-04-05

Similar Documents

Publication Publication Date Title
CN103006792B (en) A kind of herbal medicine for preventing and treating livestock and poultry intestinal canal diseases and preparation method thereof and feed
CN1201786C (en) Traditional Chinese medicine composition for curing child's dyspepsia and cough and its preparing method
CN101698024B (en) Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof
CN103006916A (en) Pure traditional Chinese medicine recipe for curing various animal diarrhoeal diseases and preparation method of pure traditional Chinese medicine recipe
CN100428950C (en) Medicine for treating chicken kidney enlargement disease
CN101698016B (en) Composition for treating cattle omasum obstruction and preparation method thereof
CN101703684B (en) Medicament for treating allergic purpura and preparation method thereof
CN111481618A (en) Traditional Chinese medicine composition with effects of preventing, treating or assisting in treating African swine fever
CN103202909B (en) Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals
CN104940404A (en) Preparation for preventing pullorum disease and preparation method
CN101972390A (en) Traditional Chinese medicine composite for preventing and treating foot-and-mouth disease and preparation method thereof
CN109568461B (en) Traditional Chinese medicine composition for treating damp-heat dysentery of pets and preparation method and application thereof
CN103800464B (en) A kind of Chinese medicine composition for the treatment of yellow and white dysentery of piglet
CN102293952B (en) Chinese medicinal composition for treating unknown swine fever
CN101879238A (en) Medicinal composition for preventing and controlling chicken colibacillosis and preparation method thereof
CN101450193B (en) Traditional Chinese medicine granules for increasing eggs
CN101524447A (en) Pharmaceutical composition for treating constipation and preparation process thereof
CN103610975A (en) Preparation method of cattle medicine for promoting digestion
CN103690842A (en) Traditional Chinese medicine for treating diarrhea of weaned piglet and preparation method thereof
CN103393891A (en) Antiviral compound traditional Chinese medicine for animals, and preparation method and use thereof
CN103479786B (en) Traditional Chinese medicine composition for treating PRRS (Porcine Reproductive and Respiratory Syndrome) and preparation method and application thereof
CN106343243A (en) Chicken feed for preventing coccidiosis
CN102698040A (en) Medicament for treating porcine respiratory disease and preparation method of medicament
CN101972328A (en) Chinese medicinal composition for treating sow milk-lacking symptom and preparation method thereof
CN105250825A (en) Traditional Chinese medicine composition for treating and preventing livestock, poultry and fur-bearing animal gastroenteritis

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant