CN105012395A - Traditional Chinese medicine for treating swine influenza and application thereof - Google Patents
Traditional Chinese medicine for treating swine influenza and application thereof Download PDFInfo
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- CN105012395A CN105012395A CN201510492940.1A CN201510492940A CN105012395A CN 105012395 A CN105012395 A CN 105012395A CN 201510492940 A CN201510492940 A CN 201510492940A CN 105012395 A CN105012395 A CN 105012395A
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Abstract
The invention discloses traditional Chinese medicine for treating swine influenza and an application thereof. A traditional Chinese medicine composition is composed of indigowoad leaves, mulberry leaves and cypress vine whole herbs. According to the traditional Chinese medicine for treating the swine influenza, the medicine preparation is scientific and reasonable, the indigowoad leaves, the mulberry leaves and the cypress vine whole herbs which are extensive in sources are selected to be used as the medicine, the efficacy of clearing heat, detoxifying, diminishing inflammation and swellings, killing worms and promoting blood circulation to remove meridian obstruction is achieved, and the traditional Chinese medicine for treating the swine influenza is suitable for treating pigs with a swine influenza symptom such as higher body temperature, poor spirit and decreased food appetite. In clinical trials, the cure rate of the traditional Chinese medicine composition reaches up to 92.5%, the invalid rate is only 5.0%, the efficacy is significant, and the traditional Chinese medicine for treating the swine influenza can be widely applied to the treatment of the swine influenza.
Description
Technical field
The present invention relates to field of animal, specifically a kind of Chinese medicine and application thereof being used for the treatment of swine flue.
Background technology
Swine influenza, be called for short swine flue (Swine influenza, SI), be acute, the hot and high degree in contact respiratory tract disease of the one of the pig caused by orthomyxovirus section swine influenza virus (Swine influenza virus, SIV).Clinical manifestation is heating, cough, asthenia universalis is unable, present the respiratory inflammation of different characteristics, and very easily cause secondary or the mixed infection of the cause of diseases such as pig breathing and breeding difficulty syndrome virus, porcine pseudorabies virus and actinobacillus pleuropneumoniae, very harmful to pig industry.The more important thing is, there is human influenza virus's receptor (SA-α-2 in porcine respiratory surface epithelial cell simultaneously, 6Gal) with bird flu virus (AIV) receptor (SA-α-2,3Gal), such pig not only can infect human influenza virus but also can infect AIV, thus becomes the ideal " blender " for people-bird flu virus restructuring.Pig in communication process, plays a part intermediate host and multiple host between the influenza kind of fowl-pig and human.Visible, swine flue not only causes great economic loss to livestock and poultry cultivation, but also threatens to the health of the mankind.
The medicine of current treatment swine flue is divided into Chinese medicine and Western medicine, because the theoretical system of Chinese medicine and western medicine is different, so Chinese medicine and Western medicine respectively have its feature to the treatment of swine flue.Western medicine is to the treatment mainly relief of symptoms of flu, prevent secondary infection, its composition mostly or compound preparation independent for the cardinal symptom of catching a cold uses, and the feature of these Western medicine is that specific aim is stronger in relief of symptoms, instant effect, but to virus mostly without obvious inhibitory action.Chinese medicine is because its prescription is unreasonable or just simple pulverizing, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine.Therefore research and develop a kind of evident in efficacy, formula reasonably treat swine flue specific medicament be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The Chinese medicine being used for the treatment of swine flue that the object of the present invention is to provide a kind of formula reasonable, evident in efficacy and application thereof.
For achieving the above object, the invention provides following technical scheme:
Be used for the treatment of a Chinese medicine for swine flue, be made up of Folium Isatidis, Folium Mori and cypress vine herb.
As the further scheme of the present invention: be made up of Folium Isatidis 12-18 part, Folium Mori 5-8 part and cypress vine herb 10-13 part according to the raw material of mass fraction.
The described application in TCM being used for the treatment of swine flue is on the medicine of preparation treatment swine flue.
As the further scheme of the present invention: described Chinese medicine composition is oral formulations.
As the further scheme of the present invention: described oral formulations is decoction, powder or granule.
Compared with prior art, the invention has the beneficial effects as follows:
Compatibility of the present invention is scientific and reasonable, select the Folium Isatidis of wide material sources, Folium Mori and cypress vine all herbal medicine, especially the Folium Isatidis selected and cypress vine herb are common natural herbs, therefore, the present invention have that raw material sources are wide, cost is low, pollution-free, have no side effect, drug residue free, the feature that has no drug resistance.
The present invention with the Folium Isatidis of heat-clearing and toxic substances removing, antiinflammatory, hemostasis for principal agent, with the cypress vine herb of heat-clearing and toxic substances removing, removing heat from blood, anti-inflammation detumescence for spoke medicine, in addition the Folium Mori of promoting blood circulation to remove obstruction in the collateral, removing toxic substances, parasite killing, all medicines share, and play effect of heat-clearing and toxic substances removing, parasite killing, anti-inflammation detumescence, promoting blood circulation and hemostasis, dredging collateral altogether.The present invention has effect of heat-clearing and toxic substances removing, anti-inflammation detumescence, parasite killing, promoting blood circulation to remove obstruction in the collateral, is applicable to the treatment of the pig of the swine influenza symptoms such as body temperature is higher, listless, loss of appetite.
By carrying out contrast test with blank group and antipyretic and detoxicated loose matched group, result of the test shows: Chinese medicine composition of the present invention obviously can alleviate the heating of ill pig, the symptom such as weak all over, within a short period of time can cure ill pig, the cure rate of Chinese medicine composition of the present invention is up to 92.5%, inefficiency only 5.0%, illustrate that the curative effect of Chinese medicine composition of the present invention is very remarkable, the treatment of swine flue can be widely used in.The application of the invention Chinese medicine composition, greatly reduces because swine flue breaks out the pig mortality rate caused, both can retrieve huge economic loss to livestock and poultry breeding industry, turn avoid the threat that the health of swine flue to the mankind causes simultaneously.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine being used for the treatment of swine flue, is made up of Folium Isatidis 12 parts, 8 parts, Folium Mori and cypress vine herb 13 parts.
The described Chinese medicine being used for the treatment of swine flue is powder, and its preparation method is: take Folium Isatidis, Folium Mori and cypress vine herb respectively by above-mentioned mass fraction, dry, chopping, mix homogeneously; After recycling Ultra-Micro Grinding Equipment will mix pulverizing medicinal materials, cross 500 mesh sieves; Mix homogeneously, obtains the Chinese medicine being used for the treatment of swine flue.The instructions of taking of this Chinese medicine composition is: boiled water brews, and wait temperature and gavage, once a day, each 15-20 gram, takes 3-7 days continuously.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine being used for the treatment of swine flue, is made up of Folium Isatidis 12 parts, 5 parts, Folium Mori and cypress vine herb 13 parts.
The described Chinese medicine being used for the treatment of swine flue is granule, and its preparation method is: take Folium Isatidis, Folium Mori and cypress vine herb respectively by above-mentioned mass fraction, dry, chopping, mix homogeneously; Add water and do not live medical material, soak 2-3 hour, pull the medical material after immersion out, decoct with water three times, add the water of 9 times amount of medical material total amount for the first time, decoct 4h, filter and obtain filtrate one and filtering residue one, filtrate one is for subsequent use, second time adds the water of 6 times amount of medical material total amount in filtering residue one, decoct 3h, filter and obtain filtrate two and filtering residue two, filtrate two is for subsequent use; In filtering residue two, add the water of 4 times amount of medical material total amount for the third time, decoct 2h, filter and obtain filtrate three and filtering residue three, filtrate three is for subsequent use; Merging three filtrates, again filtering, through being evaporated to paste; Get concentrated rear paste material, add appropriate dextrin, make granule, vacuum drying, sieve, subpackage, obtain granule.The instructions of taking of this Chinese medicine composition is: boiled water brews, and wait temperature and gavage, once a day, each 0.25g, takes 3-7 days continuously.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine being used for the treatment of swine flue, is made up of Folium Isatidis 18 parts, 5 parts, Folium Mori and cypress vine herb 10 parts.
The described Chinese medicine being used for the treatment of swine flue is decoction, and its preparation method is: take Folium Isatidis, Folium Mori and cypress vine herb respectively by above-mentioned mass fraction, dry, chopping, mix homogeneously; Add water and do not live medical material, soak 2-3 hour, pull the medical material after immersion out, decoct with water twice, add the water of 6 times amount of medical material total amount for the first time, decoct 3h, filter and obtain filtrate one and filtering residue one, filtrate one is for subsequent use, second time adds the water of 4 times amount of medical material total amount in filtering residue one, decoct 1.5h, filter and obtain filtrate two and filtering residue two, filtrate two is for subsequent use; Merge twice filtrate, again filter, obtain decoction.The instructions of taking of this Chinese medicine composition is: wait temperature and gavage, once a day, each 200ml, takes 3-7 days continuously.
The instructions of taking of Chinese medicine composition prepared by foregoing invention embodiment can also be, first according to every consumption per day, the medicine of powder, granule or decoction is added in the conventional feed of a certain meal of ill pig, after adding water or do not add water and mixing well, directly chewed by ill pig and take.
According to Chinese medicine Historical Data Data About, pharmacologically active and the source of Chinese crude drug of the present invention are as follows:
Folium Isatidis, cool in nature, sweet in the mouth is nontoxic.There is heat-clearing and toxic substances removing, antiinflammatory, hemostasis and recover the effect of liver function, promotion liver cell regeneration.Be applicable to acute calenture struvite hemorrhage, yellow cellulitis, hepatitis, pyretic stranguria, hematuria etc.Select the stem of Compositae herbaceos perennial Folium Isatidis, leaf.
Folium Mori, property is put down, and bitter in the mouth, GUIXIN, stomach warp, have effect of promoting blood circulation to remove obstruction in the collateral, removing toxic substances, parasite killing.Main cardiac and abdominal pain, rheumatic arthritis, lumbago, traumatic injury, skin ulcer tinea.Select the shoot of the drying of rosaceous plant Fructus Persicae.
Cypress vine herb: cold in nature, sweet in the mouth, has effect of heat-clearing and toxic substances removing, removing heat from blood, anti-inflammation detumescence.Cure mainly furuncle of external auditory meatus, anal fistula, venom.Select the annual weak voluble herb plant cypress vine Herb of Convolvulaceae.
Compatibility of the present invention is scientific and reasonable, select the Folium Isatidis of wide material sources, Folium Mori and cypress vine all herbal medicine, especially the Folium Isatidis selected and cypress vine herb are common natural herbs, therefore, the present invention have that raw material sources are wide, cost is low, pollution-free, have no side effect, drug residue free, the feature that has no drug resistance.
The present invention with the Folium Isatidis of heat-clearing and toxic substances removing, antiinflammatory, hemostasis for principal agent, with the cypress vine herb of heat-clearing and toxic substances removing, removing heat from blood, anti-inflammation detumescence for spoke medicine, in addition the Folium Mori of promoting blood circulation to remove obstruction in the collateral, removing toxic substances, parasite killing, all medicines share, and play effect of heat-clearing and toxic substances removing, parasite killing, anti-inflammation detumescence, promoting blood circulation and hemostasis, dredging collateral altogether.The present invention has effect of heat-clearing and toxic substances removing, anti-inflammation detumescence, parasite killing, promoting blood circulation to remove obstruction in the collateral, is applicable to the treatment of the pig of the swine influenza symptoms such as body temperature is higher, listless, loss of appetite.
Animal acute toxicity test
Animal acute toxicity test is carried out to foregoing invention embodiment, get Mouse and rat half and half, be divided into 3 groups, wherein first group of oral Chinese medicine composition of the present invention giving embodiment 1 preparation of 5000mg/kg, Chinese medicine composition of the present invention prepared by second group of oral embodiment 2 giving 5000mg/kg, Chinese medicine composition of the present invention prepared by the 3rd group of oral embodiment 3 giving 5000mg/kg, once a day, continues 7 days.To observation post administration 2 weeks, there is no dead mouse.The test dose adopted in animal acute toxicity test is all greater than more than 10 times of pig oral dose every day, and result shows this medicine and has no side effect.Therefore, clinical trial is carried out to the ill pig being diagnosed as swine flue.
Clinical data
Select 200-300 age in days, Laboratory Diagnosed is the pig 120 of swine flue, is isolated and raises separately, complete feed of feeding, and be divided into 3 groups at random, and often organize 40,3 groups of feeding environments are identical, and test period is 7 days; Blank group is left intact, and drug control group adopts antipyretic and detoxicated faling apart to treat, and specifically uses according to antipyretic and detoxicated loose description; Chinese medicine composition group of the present invention can by the ill pig of Chinese medicine composition feeding obtained by the embodiment of the present invention 3, day dose be: boiled water decocts twice, filters and obtains medicinal liquid, and wait temperature and gavage, each 200ml, every day 1 time, is used in conjunction 3-7 days; Reached the object of disease therapy by gastrointestinal absorption after oral.
Treatment effectiveness evaluation
(1) cure: sick temperature of pig body recovers normal, spirit, appetite recover normal; Respiratory symptom disappears; Sick pig is fully recovered gradually, and does not recur.
(2) effective: sick temperature of pig body recovers normal gradually, spirit, appetite recover normal gradually; Respiratory symptom obviously improves; Or sick pig is fully recovered gradually, but recur again in the observation period.
(3) invalid: after medication, sick pig symptom is not alleviated, and even increases the weight of death.
Computational methods: inefficiency=dead pig number/ill pig number × 100%, cure rate=healing pig number/ill pig number × 100%.Following table is the result (testing the 7th day) at the end of experiment.
By carrying out contrast test with blank group and antipyretic and detoxicated loose matched group, result of the test shows: Chinese medicine composition of the present invention obviously can alleviate the heating of ill pig, the symptom such as weak all over, within a short period of time can cure ill pig, the cure rate of Chinese medicine composition of the present invention is up to 92.5%, inefficiency only 5.0%, illustrate that the curative effect of Chinese medicine composition of the present invention is very remarkable, the treatment of swine flue can be widely used in.The application of the invention Chinese medicine composition, greatly reduces because swine flue breaks out the pig mortality rate caused, both can retrieve huge economic loss to livestock and poultry breeding industry, turn avoid the threat that the health of swine flue to the mankind causes simultaneously.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. be used for the treatment of a Chinese medicine for swine flue, it is characterized in that, be made up of Folium Isatidis, Folium Mori and cypress vine herb.
2. the Chinese medicine being used for the treatment of swine flue according to claim 1, is characterized in that, is made up of Folium Isatidis 12-18 part, Folium Mori 5-8 part and cypress vine herb 10-13 part according to the raw material of mass fraction.
3. the application in TCM being used for the treatment of swine flue is as claimed in claim 1 or 2 on the medicine of preparation treatment swine flue.
4. the application being used for the treatment of the Chinese medicine of swine flue according to claim 3, is characterized in that, described Chinese medicine composition is oral formulations.
5. the application being used for the treatment of the Chinese medicine of swine flue according to claim 4, is characterized in that, described oral formulations is decoction, powder or granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510492940.1A CN105012395A (en) | 2015-08-12 | 2015-08-12 | Traditional Chinese medicine for treating swine influenza and application thereof |
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| CN201510492940.1A CN105012395A (en) | 2015-08-12 | 2015-08-12 | Traditional Chinese medicine for treating swine influenza and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620453A (en) * | 2017-02-20 | 2017-05-10 | 天津市宁河区鑫瑞畜牧养殖场 | Swine influenza prescription |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614416A (en) * | 2012-03-23 | 2012-08-01 | 中山市新运来医药科技开发有限公司 | Chinese medicinal granular preparation for preventing and treating influenza A (H1N1) viruses in humans and pigs |
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- 2015-08-12 CN CN201510492940.1A patent/CN105012395A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614416A (en) * | 2012-03-23 | 2012-08-01 | 中山市新运来医药科技开发有限公司 | Chinese medicinal granular preparation for preventing and treating influenza A (H1N1) viruses in humans and pigs |
Non-Patent Citations (2)
| Title |
|---|
| 徐振娜等: "１０种中药体外抗Ｈ１Ｎ１猪流感病毒的效果研究", 《中国畜牧兽医》 * |
| 田新民等: "中草药对猪病毒性疾病的预防和控制研究进展", 《农学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620453A (en) * | 2017-02-20 | 2017-05-10 | 天津市宁河区鑫瑞畜牧养殖场 | Swine influenza prescription |
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Application publication date: 20151104 |