CN103655999A - Drug for preventing and curing avian influenza and preparation method thereof - Google Patents
Drug for preventing and curing avian influenza and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a drug for preventing and curing avian influenza. The drug is prepared through the steps as follows: firstly, measuring raw materials: measuring the following raw materials in parts by weight: 71-87 parts of astragali radix, 71-87 parts of taraxacum, 71-87 parts of sculellaria barbata, 29-35 parts of glycyrrhiza, 71-87 parts of grassleaf sweelflag rhizome, 71-87 parts of panax ginseng, 72-87 parts of privet leaves, 72-87 parts of folium isatidis, 71-87 parts of horsetail, 72-88 parts of uncaria, 86-106 parts of lotus roots, 71-87 parts of rosa laevigata, 72-88 parts of mentha; secondly, crushing and uniformly mixing the raw materials, and obtaining the drug for preventing and curing avian influenza. According to the invention, the immunity of the poultry uninfected by avian influenza virus such as chickens and ducks can be improved if the drug is taken in advance, and the drug is good in prophylactic effect and has an excellent curing effect on the poultry with the symptoms of avian influenza.
Description
Technical field
The present invention relates to medicine of a kind of fowl epidemic diseases control and preparation method thereof, particularly a kind of medicine that bird flu is had to obvious preventive and therapeutic action and preparation method thereof.
Background technology
Bird flu is the abbreviation of avian influenza, and it is the infectious disease that the hypotype by influenza A virus causes, by International Office of Epizootics, is decided to be category-A infectious disease, claims again fowl plague or European fowl plague.Be not only chicken, some other poultry and wild bird can infect bird flu, and terrestrial birds such as turkey, pigeon, guinea fowl, Carnis Coturnicis japonicae, Psittacula alexandri fasciata all can infection morbidity, but with turkey and chicken susceptible the most, M & M is all very high; The aquatic bird such as duck and goose is easy infection also, and can be with poison or inapparent infection, sometimes also can mortality.And it is as higher in duckling, its mortality rate of young goose for aquatic bird.By the type of pathogen, that bird flu can be divided into is highly pathogenic, low pathogenicity and non-pathogenic three major types.Non-pathogenic bird flu can not cause manifest symptom, produces antiviral antibody in the avian body that only makes to catch an illness.Low pathogenicity bird flu can make birds occur slight respiratory symptom, and appetite reduces, egg production declines, and occurs fragmentary dead.High pathogenic avian influenza is the most serious, and M & M is high, and the chicken group of infection usually " is annihilated ".
Bird flu virus (AIV) belongs to influenza A virus, and influenza virus belongs to the orthomyxovirus section of RNA viruses, minute first, second, the third 3 types.Wherein influenza A virus is mainly in birds, various mammals and the mankind such as some hypotype Ye Ke infected pigs, horse, sea dog and whale; B-mode and influenza virus C sees respectively the infection of sea dog and pig.Influenza A virus is pleomorphism, and wherein spherical diameter 80～120nm, has cyst membrane.Bird flu virus, according to its adventitia hemagglutinin (H)/and the difference of neuraminidase (N) protein antigenicity, can be divided into 16 H hypotypes (H1～H16) and 9 N hypotypes (N1～N9) at present.
Bird flu was found over more than 100 year, and the mankind do not grasp effectively prevention and Therapeutic Method.For avian influenza, people mainly take following measures to tackle at present:
1. slaughter the sick fowl (chicken, duck etc.) of infection.Find in time to infect or morbidity epidemic situation, and the state of virus circulation in environment, taking as early as possible such as slaughters, stop business at the measure of propagating between the elimination source of infection, blocking virus fowl, and dead birds must be burned or be buried.Although this processing method can be stretched to a certain degree controlling avian influenza, the processing cost that need to cost a lot of money, and can cause serious economic loss to raiser.
2. immunity inoculation.Avian influenza virus vaccine inoculation is the first-selected measure of current mankind flu-prevention, particularly in the season occurred frequently of bird flu, every 3～4 months, will carry out primary immune response, and the epidemic prevention of these two kinds of avian influenza vaccines takes interval and carries out for 10 days.Yet, because influenza virus serotype is numerous, once the antigenicity of influenza virus vaccine strain and epidemic strain is not mated, will cause vaccine failure, corresponding protection cannot be provided; Because the speed of influenza virus variation is very fast, the speed of vaccine research and development lags behind the speed of virus variation simultaneously, and after new epidemic strain occurs, the preparation of its corresponding vaccine at least needs the time of 6 months, causes vaccine preparation always in passive state.
3. medical treatment
Use the Chinese herbal medicine that improves immunity to coordinate responsive antibacterials to be used for the treatment of enteritis and salpingitis, then coordinate doxycycline or tylosin etc., while there is laying rate decline, in feedstuff, add vitamin B12, sodium silenite-vitamin E.Although above medical treatment can to a certain degree controlled mortality rate, improve immunity of fowl, current drug main will exist curative effect not obvious, facts have proved that mortality rate is still very high.
Summary of the invention
The object of the invention is to overcome the above-mentioned deficiency of prior art and a kind of medicine of preventing and treating bird flu is provided, medicine of the present invention can effectively be prevented and treated avian influenza; For the fowl (being mainly chicken and duck) that does not infect avian influenza, use in advance medicine of the present invention can improve immunity of fowl especially, bird flu is had to good preventive effect; For the fowl (being mainly chicken and duck) that suffers from avian influenza symptom, there is good therapeutical effect.
Another object of the present invention is to provide a kind of preparation method of said medicine, and its technique is simple, and its crude drug is common, cheap.
Technical scheme of the present invention is: a kind of medicine of preventing and treating bird flu, it is to be made by the crude drug of following proportion by weight: 71～87 parts of the Radixs Astragali, 71～87 parts of Herba Taraxacis, 71～87 parts of Herba Scutellariae Barbataes, 29～35 parts, Radix Glycyrrhizae, 71～87 parts of Rhizoma Acori Graminei, 71～87 parts of Radix Ginsengs, 72～87 parts of the Folium Ligustri Lucidis, 72～87 parts of Folium Isatidiss, 71～87 parts of Herba Equiseties Hiemalis, 72～88 parts of Ramulus Uncariae Cum Uncis, 86～106 parts of Rhizoma Nelumbinis, 71～87 parts of Fructus Rosae Laevigatae, 72～88 parts of Herba Menthaes.
Its further preferred mass part proportioning is: 75～87 parts of the Radixs Astragali, 75～87 parts of Herba Taraxacis, 75～87 parts of Herba Scutellariae Barbataes, 30～35 parts, Radix Glycyrrhizae, 75～87 parts of Rhizoma Acori Graminei, 75～87 parts of Radix Ginsengs, 75～87 parts of the Folium Ligustri Lucidis, 76～87 parts of Folium Isatidiss, 76～87 parts of Herba Equiseties Hiemalis, 76～88 parts of Ramulus Uncariae Cum Uncis, 91～106 parts of Rhizoma Nelumbinis, 75～87 parts of Fructus Rosae Laevigatae, 76～88 parts of Herba Menthaes.
Its further preferred mass part proportioning is: 71～83 parts of the Radixs Astragali, 71～83 parts of Herba Taraxacis, 71～83 parts of Herba Scutellariae Barbataes, 29～34 parts, Radix Glycyrrhizae, 71～83 parts of Rhizoma Acori Graminei, 71～83 parts of Radix Ginsengs, 72～83 parts of the Folium Ligustri Lucidis, 72～84 parts of Folium Isatidiss, 71～83 parts of Herba Equiseties Hiemalis, 72～83 parts of Ramulus Uncariae Cum Uncis, 86～101 parts of Rhizoma Nelumbinis, 71～83 parts of Fructus Rosae Laevigatae, 72～84 parts of Herba Menthaes.
Its further preferred mass part proportioning is: 75～83 parts of the Radixs Astragali, 75～83 parts of Herba Taraxacis, 75～83 parts of Herba Scutellariae Barbataes, 30～34 parts, Radix Glycyrrhizae, 75～83 parts of Rhizoma Acori Graminei, 75～83 parts of Radix Ginsengs, 75～83 parts of the Folium Ligustri Lucidis, 76～84 parts of Folium Isatidiss, 76～83 parts of Herba Equiseties Hiemalis, 76～83 parts of Ramulus Uncariae Cum Uncis, 91～101 parts of Rhizoma Nelumbinis, 75～83 parts of Fructus Rosae Laevigatae, 76～84 parts of Herba Menthaes.
Its further preferred mass part proportioning is:.
Another technical scheme of the present invention is: a kind of preparation method of preventing and treating the medicine of bird flu, it mainly comprises the steps:
One, take raw material
By following proportion by weight, take raw material: 71～87 parts of the Radixs Astragali, 71～87 parts of Herba Taraxacis, 71～87 parts of Herba Scutellariae Barbataes, 29～35 parts, Radix Glycyrrhizae, 71～87 parts of Rhizoma Acori Graminei, 71～87 parts of Radix Ginsengs, 72～87 parts of the Folium Ligustri Lucidis, 72～87 parts of Folium Isatidiss, 71～87 parts of Herba Equiseties Hiemalis, 72～88 parts of Ramulus Uncariae Cum Uncis, 86～106 parts of Rhizoma Nelumbinis, 71～87 parts of Fructus Rosae Laevigatae, 72～88 parts of Herba Menthaes;
Two, by claim raw material pulverizing, mix homogeneously, obtains preventing and treating the medicine of bird flu.
The present invention further another technical scheme is: raw material preferred mass part proportioning that step 1 takes is: 71～83 parts of the Radixs Astragali, 71～83 parts of Herba Taraxacis, 71～83 parts of Herba Scutellariae Barbataes, 29～34 parts, Radix Glycyrrhizae, 71～83 parts of Rhizoma Acori Graminei, 71～83 parts of Radix Ginsengs, 72～83 parts of the Folium Ligustri Lucidis, 72～84 parts of Folium Isatidiss, 71～83 parts of Herba Equiseties Hiemalis, 72～83 parts of Ramulus Uncariae Cum Uncis, 86～101 parts of Rhizoma Nelumbinis, 71～83 parts of Fructus Rosae Laevigatae, 72～84 parts of Herba Menthaes.
The present invention further another technical scheme is: raw material preferred mass part proportioning that step 1 takes is: 79 parts of the Radixs Astragali, 79 parts of Herba Taraxacis, 79 parts of Herba Scutellariae Barbataes, 32 parts, Radix Glycyrrhizae, 79 parts of Rhizoma Acori Graminei, 79 parts of Radix Ginsengs, 79 parts of the Folium Ligustri Lucidis, 80 parts of Folium Isatidiss, 79 parts of Herba Equiseties Hiemalis, 80 parts of Ramulus Uncariae Cum Uncis, 96 parts of Rhizoma Nelumbinis, 79 parts of Fructus Rosae Laevigatae, 80 parts of Herba Menthaes.
The present invention further another technical scheme is: after step 2 raw material pulverizing, cross 100～300 mesh sieves.
The present invention further another technical scheme is: after step 2 raw material pulverizing, cross 120～200 mesh sieves.
Main symbol and name resolving that the present invention uses are as follows:
～: numerical range, for example 1～5 represents 1 to 5.
The primary raw material medicine that the present invention uses is described as follows:
The Radix Astragali: claim again to wear crushed grain in < < Compendium of Materia Medica > >, wear mulberry, grass, hundred, Rhizoma Paridis tetraphyllae, (" stilbene " former conduct " over sixty years of age "); Abnormal smells from the patient (root) is sweet, tepor, nontoxic; Cure mainly: the yellow disease of urinary obstruction, alcoholic jaundice, nebulousurine, sallow terribly thirsty, old man's constipation, stranguria with blood, drench less, spit blood, cough pus hemoptysis, lung abscess, frequent fetal movement, polyhidrosis around the external genitals pruritus due to damp pathogen.Have invigorating the spleen and replenishing QI arresting sweating, control chronic nephritis, the albumen that disappears, removing toxic substances and promoting granulation, the effect such as strengthen the spleen and stomach.The Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting; The Radix Astragali is containing various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper; Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Herba Taraxaci, according to the record of < < Compendium of Materia Medica > >: Herba Taraxaci, release a name name weeding hoe grass, Herba Taraxaci, Herba crotalariae albidae; Abnormal smells from the patient (Seedling) is sweet, flat, nontoxic.< < Chinese medicine voluminous dictionary > > records: Herba Taraxaci, [different name] wild duck Herba Taraxaci, servant's Herba Taraxaci (< < prescriptions worth thousand gold > >), Pu Gongcao (< < Newly Revised Canon of Materia Medica > >), the public small-mouthed jar (< < Bencao Tujing > >) of falling forward, Herba Violae (< < Amplification on Materia Medica > >), comet comet fourth dish, Hemerocallis citrina Baroni Seedling, Hemerocallis citrina Baroni youth (< < Herbal for Relief of Famines > >), wood pigeon English (pungent beautiful volume > > in < < heptan), grandmother's fourth (< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >), Herba crotalariae albidae, Pu Gongding, Canis familiaris L. silkweed (< < detailed outline > >), milk grass (< < herbal classic is met former > >), yellow dog head (< < Zhiwu Mingshi Tukao > >), foretell DIWUGONG, Herba Clerodendri fortunati (< < vegetation is square > > just), Herba Malvastri Coromandeliani (< < Jiangsu flora > >), [base is former] is the herb that Compositae Dandelion plant dandelion, alkali ground Herba Taraxaci, Herba Taraxaci ohwiani, different luxuriant Herba Taraxaci, Taraxacum asiatica Dahlst, Taraxacum erythropodium Kifag etc. belong to various plants together, [function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, cure mainly acute mastitis, lung abscess, acute appendicitis, mumps, scrofula, treats carbuncle toxin, conjunctival congestion and swelling pain, cold, fever, cough, laryngopharynx swelling and pain, gastritis, enteritis, dysentery, hepatitis, cholecystitis, urinary tract infection, snake bite and insect sting, burn and scald.
Herba Scutellariae Barbatae, Herba Portulacae Grandiflorae of recording of < < Pharmacopoeia of People's Republic of China > > version in 1985 is this product.Another name: and head grass, narrow leaf Herba Scutellariae indicae, toothbrush grass, Herba Scutellariae Darbatae, Herba Scutellariae Barbatae, Herba Carpesii Cernui, Aleuritopteris argentea (Gmel.) Fee, the purple grass that connects, little Herba Scutellariae indicae, little Han letter, little scutllaria indica, Herba Carpesii Divaricati grass, box is picked one's ears, scutllaria indica, small stream limit Radix Scutellariae, wild Spica Prunellae, Fang Ercao, half to flower, demifacet flower, head is careless partially, Rabdosia stracheyi(Benth.ex Hook.f.)Hara[Plectranthus stracheyi Benth.ex Hook.f., small size India skullcap, tiger stings red, aftergrass, Herba hyperici attenuati, narrow leaf India skullcap.Prescription name: Herba Portulacae Grandiflorae, Herba Scutellariae Barbatae, fresh Herba Portulacae Grandiflorae.Effect classification: heat and toxic materials clearing away medicine; Hemorrhage.Section belongs to classification: Labiatae, Scutellaria.Function: heat clearing away, removing toxic substances, dissipating blood stasis, hemostasis, inducing diuresis to remove edema, analgesic therapy.Cure mainly: control haematemesis, epistaxis, stranguria with blood, bloody dysentery, jaundice, has sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom.Nature and flavor: acrid in the mouth; Bitter; Cold in nature.Herba Scutellariae Barbatae return through: return lung meridian; Liver Channel; Kidney channel.
Radix Glycyrrhizae: < < Chinese medicine voluminous dictionary > > records: Radix Glycyrrhizae, [different name] Glycyrrhizae, honey sweet (< < herbal classic > >), honeywort, black root grass (< < does not record > >), state old (< < Collective Notes to Canon of Materia Medica > >), well-informed (< < account pearl > >), Radix Glycyrrhizae (< < florilegium > >), Herba Hedyotis cantonensis (< < medicinal plants in China will > >), sweet root (< < Chinese medicinal herbal > >), rod grass (< < Heilungkiang Chinese medicine > >), [base is former] is the root and rhizome of pulse family glycyrrhiza genus Radix Glycyrrhizae, Glycyrrhiza glabra L., Glycyrrhiza inflata Bat., [function cures mainly] and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, asthenia lack of appetite, stomachache loose stool, the anxious pain of extremity contraction, cardiopalmus, hysteria, lung productive cough is coughed, raw with controlling laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore, infantile carbuncle, and medicine, alimentary toxicosis.According to the record of < < Compendium of Materia Medica > >: Radix Glycyrrhizae, also sweet, honeywort, Glycyrrhizae, grass of name honey, well-informed, state is old; Abnormal smells from the patient (root) is sweet, flat, nontoxic.
Rhizoma Acori Graminei: [another name] white flag, prosperous, Chinese onion when Rhizoma Acori Graminei, prosperous sun, prosperous grass, Yao, Yao's fragrant-flowered garlic, haze tallow, spring snow, see disappear, water Rhizoma Acori Graminei, bitter Rhizoma Acori Graminei, powder Chang, Rhizoma Acori Graminei, sword-like leave, Rhizoma Acori Graminei, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek, Herba Kyllingae, Rhizoma et radix valerianae.[source] medical material Ji Yuan: be the rhizome of acorus gramineus araceae plant.Gas fragrance, bitter in the mouth, micro-pungent.The bar of take is thick, section color class is white, the dense person of fragrance is as good.Meridian distribution of property and flavor: pungent, bitter, temperature.GUIXIN, stomach warp.Function cures mainly: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
Radix Ginseng: have another name called also pellet of Sphallerocarpus gracilis, Herba Wedeliae Wallichii, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), SHENCAO, Rhizoma Panacis Japonici, Herba Stellariae Saxatilis, sea fat, drawn grain, abnormal smells from the patient (root) is sweet, be slightly cold, nontoxic, cure mainly: the disease of cloudy thanks to YANG exhaustion is (giddy, spontaneous perspiration, rale, large pulse), fullness and hardness of the abdomen, coerces subinverse gas and robs the heart in the heart, deficiency of spleen-QI and stomach-QI, anorexia, appetizing is reduced phlegm, cold syndrome of the stomach fullness caused by stagnant QI, feeling of hunger but failing to eat, insufficiency of stomach bad habit, or vomiting has expectorant, regurgitation (drink vomiting while food taken, patient's languishment), pregnant woman's acid regurgitation of suffering from abdominal pain, can not diet, yang deficiency asthma, spontaneous sweating, the dizziness of breathing hard, dyspnea with rapid respiration wild, puerperal breathing heavily, puerperal all void, heating, spontaneous perspiration, puerperal, stool can not be hemorrhage a lot, the footling presentation of growing wild, palpitation with a distress feeling spontaneous perspiration, deficiency of heart-QI, chronic cough of deficiency lung, breathe heavily the hemoptysis of coughing, weak pulse is unable, cough is spitted blood, haematemesis hematochezia, Blood gushed forth in fountains, nose bleeding is more than, deficiency of YIN hematuria, water is thirsty, dysentery is fainted for a long time, six kinds of pulses Lignum Aquilariae Resinatum, prohibit a mouthful dysentery, old man's dysentery of deficiency type is more than, can not diet, bad disease of typhoid fever (typhoid fever or other epidemic diseases, disease is weak for a long time, deep-hidden pulse, syncope), typhoid fever is fainted against (slight fever, agitation, six deep-thready pulses), muscles and bones wind pain, children's's wind knots, after children's is frightened, eye tiltedly, Scolopendra, honeybee a kind of scorpion sting.There are the effects such as QI invigorating heart tonifying, detumescence, beneficial brain refreshment.
The Folium Ligustri Lucidi: [another name] Folium Ilicis Purpureae (< < sea side > >), native Buddha's warrior attendant leaf, firecracker leaf (< < Guizhou side's medicine among the people collection > >).The blade of [source] Oleaceae plants Fructus Ligustri Lucidi, can adopt the whole year.[nature and flavor] < < detailed outline > >: micro-hardship, flat, nontoxic.[function cures mainly] dispels the wind, improving eyesight, detumescence, pain relieving.Control head's dusk pain, wind heat is red follows, and skin ulcer turgescence canker is scalded stomatitis.1. < < detailed outline > >: except the loose blood of wind, subduing swelling and relieving pain.Control head's dusk pain, all malignant boil are swollen, and top gem of a girdle-pendant skin ulcer is festered, and person is with decocting in water for a long time, take advantage of heat posted it, again and again change easily, rice vinegar boils also can.Aphtha of the mouth and tongue, glossoncus expansion, smashes juice impregnation salivation.2. < < Guizhou side's medicine among the people collection > >: external application is only hemorrhage due to wound, and anti-inflammation detumescence, controls burn.For oral administration can cough-relieving coughing, emesis blood.
Folium Isatidis: [another name] Folium Isatidis (< < book on Chinese herbal medicine Jing Ji village > >), LANYE, blue dish, blue buttocks leaf.Leaf or the branch and leaf of [source] cruciferae isatis.Medical material nature and flavor: hardship, cold.1. < < does not record > >: " bitter in the mouth is Great Cold, nontoxic." 2. < < property of medicine opinion > >: " sweet in the mouth." 3. < < detailed outline > >: " gas is cold, and mildly bitter flavor is salty." [return through] enters liver, the heart, stomach warp.1. < < must join herbal > >: " enter foot sun bright, meridian of Hand-SHAO YIN." 2. < < book on Chinese herbal medicine newer > >: " enter liver, spleen two warps." 3. < < book on Chinese herbal medicine brief points > >: " enter foot fall the moon, shaoyin channel."。Function cures mainly: heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Herba Equiseti Hiemalis: another name: file grass, nib grass, Herba equiseti ramosissimi, Herba Equiseti Hiemalis etc. are Equisetaceae plant Herba Equiseti Hiemalis's herb.[nature and flavor] are sweet, bitter, flat.[return through] returns lung, Liver Channel.[function cures mainly] wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, nebula removing.Control the raw nebula of order, epiphora induced by wind, discharging fresh blood stool, dysentery, de-liver, malaria, laryngalgia, carbuncle.1. < < praises blessing book on Chinese herbal medicine > >: " argument disease, nebula removing film.Removing food stagnancy piece again, the liver benefiting gallbladder, improving eyesight, treats hemorrhoidal hamorrhage, dysentery relieving and married woman's metrorrhagia."; 2. < < detailed outline > >: " expelling pathogenic factors from muscles, arresting lacrimation, hemostasis, curing rheumatism, colic, large intestine proctoptosis."; 3. the positive > > of < < book on Chinese herbal medicine: " diaphoresis, expelling pathogenic factors from muscles.Cure the wound cold, malaria.Curing rheumatism, loose pathogenic fire."
Ramulus Uncariae Cum Uncis, calls large Ramulus Uncariae Cum Uncis, Ramulus Uncariae macrophyllae, is a kind of evergreen liana.The Ramulus Uncariae Cum Uncis beginning is loaded in < < Mingyi Bielu > >, original name Ramulus Uncariae cum Uncis.[section belongs to classification]: Rubiaceae.[effect classification]: liver wind calming drug.[another name]: hang rattan, Ramulus Uncariae Cum Uncis hook, fishhook rattan, Oriolus chinensis diffusus pawl wind, tender hook hook, golden Ramulus Uncariae Cum Uncis, hook rattan, Ramulus Uncariae Cum Uncis, Ramulus Uncariae Cum Uncis, lifting lug, Ramulus Uncariae macrophyllae, Wang Gambirplant Branchlet, reversal of the natural order of things is perverse.[nature and flavor]: sweetness and bitterness; Be slightly cold.[return through]: < Liver Channel < heart channel.[function]: heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind.[curing mainly]: infantile convulsion; Night cry; Intenseness of heat wind symptom; Eclamposia; Dizziness due to hyperactivity of liver-YANG; Liver-fire distending pain in the head.
Rhizoma Nelumbinis: claim again Rhizoma Nelumbinis, belong to nymphaeaceae plant, Rhizoma Nelumbinis is micro-sweet and crisp, can eat raw also and can cook, and medical value is quite high, its Gen Genyeye, and stamen or pistil fruit, is precious invariably, all can nourish and be used as medicine.Nature and flavor: sweet in the mouth, cool in nature, main invigorating middle warmer is burnt, repose, physical strength profiting.Energy clearing away heat and promoting production of body fluid, cooling blood for hemostasis, dissipating blood stasis blood.The ripe tepor of using, can strengthen the spleen and stomach, antidiarrheal, beneficial blood, granulation promoting.Cure mainly: invigorating middle warmer is reposed, except all kinds of diseases and ailments.Informal dress, makes light of one's life by commiting suicide resistance to old, life lengthening.Tonification twelve regular channels vim and vigour, flat body Nei Yangre crosses Sheng, hyperactivity of fire.The kidney of laying one's heart bear, thick the intestines and stomach, controlling nocturnal emission with astringent drugs gas, bone and muscle strengthening, tonifying deficiency, the disease such as sharp knowledge, and eliminating cold-damp, stop the splenic diarrhea chronic dysentery, woman's Massive Bleeding in non-menstrual period.Eat too much fine motion gas raw.Smash to pieces and the rice food of cooking congee, make people strong, steamed wheaten foods might as well.The dry puckery people that defecates can not eat it.Lotus is fruit of strengthening the spleen.
Fructus Rosae Laevigatae: Fructus Rosae Laevigatae another name: Cortex Hemipteleae Davidii, thorn pear, golden small-mouthed jar, Catunaregam spinosa (Thunb.) Tirveng., Gallus jabouillei chieftain, sugared Oriolus chinensis diffusus, sugar bowl, confection, Mel tank, Semen Arecae, golden tall bottle with spout, sugared Fructus Citri tangerinae, yellow tea bottle, rattan hook, Mantidis fruit, sugared bur, Radix Ribis manschurici, thorn Fructus Canarii albi, Radix Ribis manschurici, the blue stalk of thorn are rosaceous plant.Source: this product is the dry mature fruit of rosaceous plant Fructus Rosae Laevigatae.[performance] sweet in the mouth, micro-acid, puckery, property is flat.Energy controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.Function cures mainly: 1, controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.2, reducing urination for preventing enuresis.3, relieving cough and asthma, spasmolytic.4, blood fat reducing.5, anti-inflammation.[nature and flavor]: really: sour, sweet, flat, nontoxic.[function]: astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, stopping leak dysentery, urine reducing.[effect]: astringent therapy, controlling nocturnal emission with astringent drugs, antidiarrheal.Be applicable to the diseases such as spermatorrhea, seminal emission, the enuresis, frequent micturition, insufficiency of the spleen chronic diarrhea and women's leukorrhagia, uterine prolapse.During catching a cold or heating patient's inedibility.
Herba Menthae: another name wild mint.Function cures mainly: 1. for anemopyretic cold, epidemic febrile disease from the beginning of.These product are pungent to disperse, cool to heat clearing away, clear light cool loose, are the product that dispelling wind and heat pathogens is conventional, control anemopyretic cold or epidemic febrile disease from the beginning of, evil defending minute therefore available, and headache, heating, the micro evil wind person that trembles with fear often joins Flos Lonicerae, sticks up, Fructus Arctii, Herba Schizonepetae be equal to use, as Lonicerae and Forsythiae Powder.2. for the conjunctival congestion of having a headache, laryngopharynx swelling and pain.These product lightly float and rise floating, awakening consciousness, kind part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, the throat evacuated of merit.With controlling in wind heat, attack, headache conjunctival congestion, polygamy closes Folium Mori, Flos Chrysanthemi, Fructus Viticis and is equal to use; With controlling wind heat, stop up to contain, laryngopharynx swelling and pain, often joins Radix Platycodonis, Radix Glycyrrhizae, Bombyx Batryticatus, Herba Schizonepetae, Radix Saposhnikoviae and is equal to use.3. for measles without adequate eruption, rubella pruritus.A surname is loose for this product light weight, has dispelling wind and heat pathogens, declares the merit of malicious rash, and with controlling wind heat bundle table, measles without adequate eruption, often joins Periostracum Cicadae, Herba Schizonepetae, Fructus Arctii, Radix Arnebiae (Radix Lithospermi) etc., as rash soup; Treatment rubella pruritus, can be equal to use with Radix Sophorae Flavescentis, Cortex Dictamni, Radix Saposhnikoviae, gets the antipruritic effect of its rash of dispeling the wind.4. for stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.These product are double enters Liver Channel, can dispersing the stagnated live-QI to relieve the stagnation of QI, often coordinate the product of the depressed liver-energy dispersing and QI regulating regulating menstruations such as Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, and treatment stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, menoxenia, as XIAOYAO POWDER.Meridian distribution of property and flavor: pungent, cool.Enter lung meridian, Liver Channel.
< < Chinese medicine voluminous dictionary > >: < < Chinese medicine voluminous dictionary > > second edition is write by Nanjing University of Traditional Chinese Medicine, Shanghai Century publishes limited company and Shanghai science tech publishing house publishes and distributes.
Efficacy of drugs of the present invention with cure mainly:
1. medicine of the present invention has the effect of heat-clearing and toxic substances removing, cooling blood, expelling wind, enhancing immunity;
2. the following symptom of pair fowl has obvious preventive and therapeutic effect: fervescence to 38.0 ℃～40.0 ℃, spirit is depressed, fb dur loss of appetite or do not eat, feather pine disorderly, furious shedding tears, conjunctiva inflammation, secretions increase, respiratory disorder, coughs, gets rid of head, sneeze;
3. the inventor, by a large amount of contrast control tests, fully proves that the medicine of control bird flu of the present invention has obvious preventive and therapeutic action to avian influenza, can control well the mortality rate of fowl.
4. pure Chinese medicine is made, few side effects.
In order to be illustrated more clearly in the present invention, enumerate following examples, but it is without any restrictions to scope of invention.
The specific embodiment
embodiment 1
Take 700 grams of Spina Gleditsiaes, 700 grams of Rhizoma Phragmitiss, 420 grams of astragalus polysaccharidess, 700 grams of Radix Saposhnikoviaes, 710 grams of Ramulus Cinnamomi, 700 grams of Radix Bupleuri, 710 grams of Herba Dendrobiis, 700 grams of Endothelium Corneum Gigeriae Galli, 720 grams of Radix Notoginseng, 700 grams of Radix Salviae Miltiorrhizaes, 1130 grams of Rhizoma Osmundae, 700 grams of Fructus Schisandrae Chinensis, 710 grams of Fructus Gardeniaes, 700 grams of Herba Lobeliae Chinensis, these material compositions are the quality after drying, with super micron mill, be ground into 100～300 orders (being generally 120～200 orders), mix homogeneously, then with plastic bag sealing, pack, make the medicine of control bird flu.
using method:during each nursing, according to forage volume, take the medicine (being the medicine that each hundred kilograms of feedstuff takes the control bird flu that the present embodiment of 1.5 to 2.0 kilograms obtains) of the control bird flu that the present embodiment of 1.5～2.0% feeding qualities obtains, again by this medicine with appropriate water to mixing up, then add in feedstuff, mix all, feed immediately, every day, sooner or later each was fed once, within 4～7 days, was a course for the treatment of, fed a course for the treatment of of this medicine every 30 days.
contrast control test:
1. the symptom standard (for judging the state of an illness) for observing:
Symptom 1: non-evident sympton, avian flu virus detection is negative, healthy;
Symptom 2: fervescence to 38.0 ℃～40.0 ℃, sick chicken spirit is depressed, fb dur loss of appetite or do not eat, feather pine disorderly, is envious and sheds tears, conjunctiva inflammation, secretions increase, respiratory disorder, cough, get rid of head, sneeze, sample (be generally propose serum) detects bird flu virus and is positive, and infects;
Symptom 3: fervescence to 40.5 ℃～41 ℃, breathing is the devil, serious dysentery, row's yellow green feces, skin is dark violet without hair place color, has nervous symptoms, and performance head and neck, to layback, is twitched, movement disorder, paralysis etc., sample (being generally to propose serum) detects bird flu virus and is positive; Serious;
Symptom 4: 41 ℃ of left and right of body temperature, are septicemia phenomenon, extensive bleeding; Peritoneum, serous coat, intestinal are hemorrhage to some extent, often have hyperemia, hemorrhage and gangrenosum acne symptom, cloaca hemorrhagic necrosis on skin, cockscomb, wattle; Can see stomach fat, lower limb flesh, chest muscle hemorrhage, sample (being generally to propose serum) detects bird flu virus and is positive; Be critically ill;
Symptom 5: death.
2. control is divided into four-stage (natural law in each stage all goes out the birthday from chicken and starts at) course for the treatment of:
First stage: the 1st day～the 30th day;
Second stage: the 31st day～the 60th day;
Phase III: the 61st day～the 120th day;
Fourth stage: the 121st day～the 180th day.
3. group experiment.
When within 2011, there is bird flu in Hunan, the inventor has bought 100 of chickens (birth 5-10 days), be divided into two groups, every group 50, in Hengyang one Yang Zhi ?raise, cultivation place between two groups of chickens is separated with wire gauze, the medicine that first group of 50 chicken are the control bird flu that makes by the present embodiment is prevented and treated test group (being that embodiment prevents and treats test group), and second group of 50 chicken prevents and treats test group (contrast and prevent and treat test group) for contrast by currently available vaccines, existing vaccines and antibiotic.
4. embodiment prevents and treats test group: first group of 50 chicken adds respectively the medicine of the control bird flu that the present embodiment of 1.5～2.0% obtains sooner or later during feeding in feedstuff, use 7 days continuously, during by the 10th day, for first course for the treatment of (being the first stage), there are 3 chickens to occur that avian influenza symptom 2(infects), all 50 chickens are carried out to avian flu virus detection, and it is positive that result detects the bird flu viruss of 5 chickens, and it is healthy that all the other are symptom 1(); The feedstuff 7 days that feed to add again the medicine of the present embodiment after 30 days, is second course for the treatment of (being second stage), has 4 chickens to occur that avian influenza symptom 2(infects), all the other are symptom 1; Again through within 30 days, feed adding again the feedstuff 4 days of the medicine of the present embodiment, not only through 30 days but also feed the feedstuff 4 days of the medicine that adds the present embodiment, be the 3rd course for the treatment of (being the phase III), have 2 chickens to occur that avian influenza symptom 2(infects), all the other are symptom 1; Again through within 30 days, feed adding again the feedstuff 4 days of the medicine of the present embodiment, not only through 30 days but also feed the feedstuff 4 days of the medicine that adds the present embodiment, while delivering for sale to 6 months (fourth stage), be all that symptom 1(is all healthy chicken), the average weight of 50 chickens increases by 1.3 kilograms, does not occur dead.
5. contrast prevents and treats test group:
The inoculation of injection avian influenza virus vaccine, then coordinate doxycycline or tylosin etc., the medicines such as vitamin B12, sodium silenite-vitamin E.
Second group of 150 chicken are all injected avian influenza virus vaccine inoculation control, through 10 days, i.e. and first stage, there are 5 chickens to occur symptom 2, have 2 chickens to occur symptom 3, all the other are symptom 1, then to occurring that the chicken of symptom 2,3 is fed doxycycline, tylosin is treated; During second stage (by the 60th day time), there are 10 chickens to occur symptom 2, have 8 chickens to occur symptom 3, have 2 chickens to occur symptom 4, all the other are symptom 1, then to there is chicken nursing doxycycline, the tylosin of symptom 2, symptom 3, symptom 4, every 30 days, once feed control, one time 4 days; During the phase III (by the 120th day time), there are 15 chickens to occur symptom 2, there are 10 chickens to occur symptom 3, there are 8 chickens to occur symptom 4, have 8 chickens to occur symptom 5 (dead), all the other are symptom 1, then to there is chicken nursing doxycycline, the tylosin of symptom 2, symptom 3, symptom 4, every 30 days, once feed control, one time 4 days; During fourth stage (by the 180th day time), have 10 chickens to occur symptom 2, have 11 chickens to occur symptom 3, have 8 chickens to occur symptom 4, have again 10 chickens to occur symptom 5 (dead), all the other are symptom 1,0.7 kilogram of remaining chicken average weight gain; Mortality rate is 36%.
embodiment 2-14
Embodiment 2-14 is except raw material mass mixture ratio is different from embodiment 1, its raw material type and step of preparation process are identical with embodiment 1, as shown in Table 1 below, table 1 below shows raw material and the quality that embodiment 1-14 is used for the raw material that embodiment 2-14 is used and quality.
Table 1
The inventor also adopts respectively the medicine of embodiment 2-14 to do Contrast control test substantially the same manner as Example 1 different local during within 2011 to 2013, there is bird flu, embodiment 1-14 altogether contrast test 1400 chickens.While feeding by medicine of the present invention 700 chickens to 6 month that carry out avian influenza prevention, only have 10 death, mortality rate is 1.4%, is weak and sickly chicken itself mostly, 1.2 kilograms of the chicken average weight gains of living; And while adopting prior art to prevent and treat 700 chickens to 6 month of comparative example, 220 death, mortality rate 31%, 0.8 kilogram of the chicken average weight gain of living.By contrast culture experiment, show that medicine of the present invention has good prevention effect to avian influenza.
The inventor also adopts the present invention, and each is implemented, during 2011 to 2013,1000 ducks have been cooked to contrast culture experiment, by the time with the essentially identical culture experiment result of chicken, adopt 500 of the ducks that this medicine feeds, duck mortality rate is 1.1%, weak and sickly duck itself mostly, 1.5 kilograms of the duck average weight gains of living; And adopt 500 duck mortality rates of duck of prior art control, be 29%, 0.9 kilogram of the duck average weight gain of living.
From above contrast control test data, can find out, the medicine of bird flu of the present invention has obvious preventive and therapeutic action to avian influenza.
So the present invention is not limited to the control medicine as bird flu, so long as within composition of raw materials medicine identical with the present invention or that be equal to just drops on protection scope of the present invention.The raw material of the control medicine same recipe with control bird flu of the present invention is made within any Chinese medicine preparation also drops on protection scope of the present invention, within as long as the composition of raw materials medicine identical with the present invention just drop on protection scope of the present invention.
Claims (10)
1. a medicine of preventing and treating bird flu, is characterized in that: it is to be made by the crude drug of following proportion by weight: 71～87 parts of the Radixs Astragali, 71～87 parts of Herba Taraxacis, 71～87 parts of Herba Scutellariae Barbataes, 29～35 parts, Radix Glycyrrhizae, 71～87 parts of Rhizoma Acori Graminei, 71～87 parts of Radix Ginsengs, 72～87 parts of the Folium Ligustri Lucidis, 72～87 parts of Folium Isatidiss, 71～87 parts of Herba Equiseties Hiemalis, 72～88 parts of Ramulus Uncariae Cum Uncis, 86～106 parts of Rhizoma Nelumbinis, 71～87 parts of Fructus Rosae Laevigatae, 72～88 parts of Herba Menthaes.
2. the medicine of control bird flu according to claim 1, is characterized in that: 75～87 parts of the Radixs Astragali, 75～87 parts of Herba Taraxacis, 75～87 parts of Herba Scutellariae Barbataes, 30～35 parts, Radix Glycyrrhizae, 75～87 parts of Rhizoma Acori Graminei, 75～87 parts of Radix Ginsengs, 75～87 parts of the Folium Ligustri Lucidis, 76～87 parts of Folium Isatidiss, 76～87 parts of Herba Equiseties Hiemalis, 76～88 parts of Ramulus Uncariae Cum Uncis, 91～106 parts of Rhizoma Nelumbinis, 75～87 parts of Fructus Rosae Laevigatae, 76～88 parts of Herba Menthaes.
3. the medicine of control bird flu according to claim 1, is characterized in that: 71～83 parts of the Radixs Astragali, 71～83 parts of Herba Taraxacis, 71～83 parts of Herba Scutellariae Barbataes, 29～34 parts, Radix Glycyrrhizae, 71～83 parts of Rhizoma Acori Graminei, 71～83 parts of Radix Ginsengs, 72～83 parts of the Folium Ligustri Lucidis, 72～84 parts of Folium Isatidiss, 71～83 parts of Herba Equiseties Hiemalis, 72～83 parts of Ramulus Uncariae Cum Uncis, 86～101 parts of Rhizoma Nelumbinis, 71～83 parts of Fructus Rosae Laevigatae, 72～84 parts of Herba Menthaes.
4. the medicine of control bird flu according to claim 1, is characterized in that: 75～83 parts of the Radixs Astragali, 75～83 parts of Herba Taraxacis, 75～83 parts of Herba Scutellariae Barbataes, 30～34 parts, Radix Glycyrrhizae, 75～83 parts of Rhizoma Acori Graminei, 75～83 parts of Radix Ginsengs, 75～83 parts of the Folium Ligustri Lucidis, 76～84 parts of Folium Isatidiss, 76～83 parts of Herba Equiseties Hiemalis, 76～83 parts of Ramulus Uncariae Cum Uncis, 91～101 parts of Rhizoma Nelumbinis, 75～83 parts of Fructus Rosae Laevigatae, 76～84 parts of Herba Menthaes.
5. according to the medicine of the control bird flu described in claim 1 or 2 or 3 or 4, it is characterized in that: 79 parts of the Radixs Astragali, 79 parts of Herba Taraxacis, 79 parts of Herba Scutellariae Barbataes, 32 parts, Radix Glycyrrhizae, 79 parts of Rhizoma Acori Graminei, 79 parts of Radix Ginsengs, 79 parts of the Folium Ligustri Lucidis, 80 parts of Folium Isatidiss, 79 parts of Herba Equiseties Hiemalis, 80 parts of Ramulus Uncariae Cum Uncis, 96 parts of Rhizoma Nelumbinis, 79 parts of Fructus Rosae Laevigatae, 80 parts of Herba Menthaes.
6. a preparation method of preventing and treating the medicine of bird flu, is characterized in that: it mainly comprises the steps:
One, take raw material
By following proportion by weight, take raw material: 71～87 parts of the Radixs Astragali, 71～87 parts of Herba Taraxacis, 71～87 parts of Herba Scutellariae Barbataes, 29～35 parts, Radix Glycyrrhizae, 71～87 parts of Rhizoma Acori Graminei, 71～87 parts of Radix Ginsengs, 72～87 parts of the Folium Ligustri Lucidis, 72～87 parts of Folium Isatidiss, 71～87 parts of Herba Equiseties Hiemalis, 72～88 parts of Ramulus Uncariae Cum Uncis, 86～106 parts of Rhizoma Nelumbinis, 71～87 parts of Fructus Rosae Laevigatae, 72～88 parts of Herba Menthaes;
Two, by claim raw material pulverizing, mix homogeneously, obtains preventing and treating the medicine of bird flu.
7. the preparation method of the medicine of control bird flu according to claim 6, is characterized in that: raw materials quality part proportioning that step 1 takes is: 75～83 parts of the Radixs Astragali, 75～83 parts of Herba Taraxacis, 75～83 parts of Herba Scutellariae Barbataes, 30～34 parts, Radix Glycyrrhizae, 75～83 parts of Rhizoma Acori Graminei, 75～83 parts of Radix Ginsengs, 75～83 parts of the Folium Ligustri Lucidis, 76～84 parts of Folium Isatidiss, 76～83 parts of Herba Equiseties Hiemalis, 76～83 parts of Ramulus Uncariae Cum Uncis, 91～101 parts of Rhizoma Nelumbinis, 75～83 parts of Fructus Rosae Laevigatae, 76～84 parts of Herba Menthaes.
8. the preparation method of the medicine of control bird flu according to claim 6, is characterized in that: raw materials quality part proportioning that step 1 takes is: 79 parts of the Radixs Astragali, 79 parts of Herba Taraxacis, 79 parts of Herba Scutellariae Barbataes, 32 parts, Radix Glycyrrhizae, 79 parts of Rhizoma Acori Graminei, 79 parts of Radix Ginsengs, 79 parts of the Folium Ligustri Lucidis, 80 parts of Folium Isatidiss, 79 parts of Herba Equiseties Hiemalis, 80 parts of Ramulus Uncariae Cum Uncis, 96 parts of Rhizoma Nelumbinis, 79 parts of Fructus Rosae Laevigatae, 80 parts of Herba Menthaes.
9. according to the preparation method of the medicine of the control bird flu described in claim 6 or 7 or 8, it is characterized in that: after step 2 raw material pulverizing, cross 100～300 mesh sieves.
10. the preparation method of the medicine of control bird flu according to claim 9, is characterized in that: after step 2 raw material pulverizing, cross 120～200 mesh sieves.
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| CN106309679A (en) * | 2016-08-26 | 2017-01-11 | 唐莹 | Traditional Chinese veterinary medicine preparation for treating avian influenza |
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