CN107308235A - A kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis - Google Patents
A kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to veterinary drug preparation production and applied technical field, there is provided a kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis.The Chinese medicine composition of the preventing and treating chicken coccidiasis, is counted by weight, and its raw material includes：Sophora flower, garden burnet, Artemisia japonica, Radix Codonopsis and honeysuckle.The excellent effect of the traditional Chinese medicine composition for treating chicken coccidiasis, and drug resistance will not be produced, also have no toxic side effect, be difficult to remain in poultry body.The preparation method includes smashing to form mixture after mixing sophora flower, garden burnet, Artemisia japonica, Radix Codonopsis and honeysuckle by weight；Mixture is added to ethanol formation mixed liquor, is filtered after mixed liquor is soaked, collects filtrate, then filtrate is concentrated.The preparation method is simple and easy to apply, and operation is reliable, can prepare the Chinese traditional medicine composition of preventing and treating chicken coccidiasis excellent performance.
Description
Technical field
The invention belongs to veterinary drug preparation production and applied technical field, specifically, it is related to a kind of preventing and treating chicken coccidiasis
Chinese medicine composition and preparation method.
Background technology
Chicken coccidiasis is the parasitic disease that chicken is common and harm is extremely serious, is acute as caused by one or more coccidias
Popular parasitic disease.The economic loss that it is caused is surprising.The chick of 10~30 ages in days or the young chicken of 35~60 ages in days
The incidence of disease and fatal rate may be up to 80%.The chick growth recovered is obstructed, and weightening is slow；Adult Chicken is not fallen ill typically, but is
Carrier, weightening and egg laying performance reduction, are the important pathogenies for propagating global-worm illness.
At present, there is coccidia easily to drug resistant in the medicine of conventional treatment chicken coccidiasis；Anticoccidial drug holds
Easily residue in poultry or egg product, threaten human health；Poultry medication expense headlight shortcoming.
Therefore, inventing a kind of novel drugs of the preventing and treating chicken coccidiasis solved the above problems becomes urgently to be resolved hurrily at present ask
Topic.
The content of the invention
For deficiency above-mentioned in the prior art, the first object of the present invention is to provide in a kind of preventing and treating chicken coccidiasis
Drug composition, the excellent effect of the traditional Chinese medicine composition for treating chicken coccidiasis, and drug resistance will not be produced, also have no toxic side effect, no
Easily remain in poultry body.
The second object of the present invention is to provide a kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis, the preparation
Method is simple and easy to apply, and operation is reliable, can prepare the Chinese medicine composition of preventing and treating chicken coccidiasis excellent performance.
In order to achieve the above object, the preferred solution that uses of the present invention is：
A kind of Chinese medicine composition for preventing and treating chicken coccidiasis, is counted, its raw material includes by weight：35-55 parts of sophora flower,
15-20 parts of 40-50 parts of elm, 20-28 parts of Artemisia japonica, 16-25 parts of Radix Codonopsis and honeysuckle.
Further, in preferred embodiments of the present invention, count by weight, sophora flower is 38-52 parts, garden burnet is 42-
48 parts, Artemisia japonica be 22-26 parts, Radix Codonopsis is 18-22 parts and honeysuckle is 16-19 parts.
Further, in preferred embodiments of the present invention, count by weight, sophora flower is 40 parts, garden burnet is 45 parts, male
Wormwood artemisia is 25 parts, Radix Codonopsis is 20 parts and honeysuckle is 18 parts.
Further, in preferred embodiments of the present invention, the formulation of Chinese medicine composition includes powder, granule or oral
Liquid.
Further, in preferred embodiments of the present invention, by sophora flower, garden burnet, Artemisia japonica, Radix Codonopsis and honeysuckle by weight
Smashed after amount number mixing to 80-100 mesh formation mixture；Mixture is added to 80-90% ethanol formation mixed liquor,
Filtered after mixed liquor is carried out into immersion 72-120 hours, collect filtrate, then filtrate is concentrated.
Further, in preferred embodiments of the present invention, the weight ratio of mixture and ethanol is 1:6-8.
Further, in preferred embodiments of the present invention, the relative density of concentration filtrate to filtrate is 1.2-1.4g/
ml。
The preventing and treating Chinese medicine composition of chicken coccidiasis and the beneficial effect of preparation method that the present invention is provided be：
(1) Chinese medicine composition of preventing and treating chicken coccidiasis provided in an embodiment of the present invention is with the Chinese scholartree of clearing heat and detoxicating cool blood moistening lung
Flower and cooling blood and hemostasis, the garden burnet of removing toxic substances sore is monarch, is dissipated with wind dispelling, and the Artemisia japonica that inducing diaphoresis is brought down a fever is minister, and assistant is mended with nourishes blood and promotes the production of body fluid
The Radix Codonopsis of spleen benefit lung and remove heat from the blood and relieve diarrhea, clearing heat and detoxicating honeysuckle, gather altogether cool blood by becoming silted up, the work(of clearing heat and detoxicating, solid first reinforcing
Effect.
Above-mentioned each raw material components play a part of coordinated simultaneously, and its drug effect of obtained Chinese medicine composition is comprehensive, can
Play effect of excellent preventing and treating chicken coccidiasis.By weight meter sophora flower be 35-55 parts, garden burnet be 40-50 parts, Artemisia japonica be
20-28 parts, Radix Codonopsis is 16-25 parts and honeysuckle is 15-20 parts.The ratio range is pressed through inventor's creativeness experiment gained
The preparation-obtained Chinese medicine composition of raw material prepared according to the proportioning, with excellent prophylactic-therapeutic effect, especially when sophora flower is 40
Part, garden burnet be 45 parts, Artemisia japonica be 25 parts, Radix Codonopsis is 20 parts and prevention effect when honeysuckle is 18 parts is more excellent.
(2) it is provided in an embodiment of the present invention preventing and treating chicken coccidiasis Chinese medicine composition formulation preferably include powder,
Granula or oral liquid, those formulations are convenient for carrying and eaten.
(3) it is provided in an embodiment of the present invention preventing and treating chicken coccidiasis Chinese medicine composition preparation method, by sophora flower, garden burnet,
Artemisia japonica, Radix Codonopsis and honeysuckle are smashed after mixing by weight to 80-100 mesh formation mixture；Wherein, smashing raw material is
In order that its drug effect is fully played, it can be substantially dissolved in provide in solvent also for active principle in follow-up raw material and protect
Barrier, when crushing 80-100 mesh, can farthest volatilize drug effect；Then, mixture is added to ethanol formation mixed liquor, it is excellent
Selection of land, it is contemplated that drug effect farthest dissolves, it is preferable that the concentration of ethanol is 80-90%, and in view of drug effect at utmost
Dissolve on ground, it is preferable that the weight ratio of mixture and ethanol is 1:6-8；Then, by mixed liquor carry out immersion 72-120 hours it is laggard
Row filtering, collects filtrate, then filtrate is concentrated, it is contemplated that conveniently prepare various formulations, it is preferable that be concentrated into filtrate
Relative density is that the active principle that 1.2-1.4g/ml immersions are conducive in raw material for 72-120 hours is fully dissolved.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional production that can be obtained by commercially available purchase
Product.
Embodiment 1
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：35 parts of sophora flower,
15 parts of 40 parts of elm, 20 parts of Artemisia japonica, 16 parts of Radix Codonopsis and honeysuckle.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：35 parts of sophora flower, 40 parts of garden burnet, 20 parts of Artemisia japonica, party
15 parts of 16 parts of ginseng and honeysuckle are smashed after mixing by weight to 80-100 mesh formation mixture；According to mixture and second
Alcohol weight ratio is 1:6, mixture is added to 80-90% ethanol formation mixed liquor, it is small that mixed liquor is carried out into immersion 72-120
When after filtered, collect filtrate, then filtrate concentrated, powder is prepared according to a conventional method.
Embodiment 2
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：55 parts of sophora flower,
20 parts of 50 parts of elm, 28 parts of Artemisia japonica, 25 parts of Radix Codonopsis and honeysuckle.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：55 parts of sophora flower, 50 parts of garden burnet, 28 parts of Artemisia japonica, party
20 parts of 25 parts of ginseng and honeysuckle are smashed after mixing by weight to 80-100 mesh formation mixture；According to mixture and second
Alcohol weight ratio is 1:6, mixture is added to 80-90% ethanol formation mixed liquor, it is small that mixed liquor is carried out into immersion 72-120
When after filtered, collect filtrate, then filtrate concentrated, powder is prepared according to a conventional method.
Embodiment 3
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：Sophora flower be 38 parts,
Garden burnet is 42 parts, Artemisia japonica is 22 parts, Radix Codonopsis is 18 parts and honeysuckle is 16 parts.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：Sophora flower is 38 parts, garden burnet is 42 parts, Artemisia japonica is 22
Part, Radix Codonopsis be 18 parts and honeysuckle be 16 parts mix by weight after smash to 80-100 mesh formation mixture；According to
Mixture is 1 with ethanol weight ratio:6, mixture is added to 80-90% ethanol formation mixed liquor, mixed liquor is soaked
Bubble is filtered after 72-120 hours, collects filtrate, then filtrate is concentrated, and powder is prepared according to a conventional method.
Embodiment 4
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：Sophora flower be 52 parts,
Garden burnet is 50 parts, Artemisia japonica is 28 parts, Radix Codonopsis is 25 parts and honeysuckle is 20 parts.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：Sophora flower is 52 parts, garden burnet is 50 parts, Artemisia japonica is 28
Part, Radix Codonopsis be 25 parts and honeysuckle be 20 parts mix by weight after smash to 80-100 mesh formation mixture；According to
Mixture is 1 with ethanol weight ratio:6, mixture is added to 80-90% ethanol formation mixed liquor, mixed liquor is soaked
Bubble is filtered after 72-120 hours, collects filtrate, then filtrate is concentrated, and powder is prepared according to a conventional method.
Embodiment 5
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：Sophora flower be 45 parts,
Garden burnet is 25 parts, Artemisia japonica is 20 parts, Radix Codonopsis is 20 parts and honeysuckle is 18 parts.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：Sophora flower is 45 parts, garden burnet is 25 parts, Artemisia japonica is 20
Part, Radix Codonopsis be 20 parts and honeysuckle be 18 parts mix by weight after smash to 80-100 mesh formation mixture；According to
Mixture is 1 with ethanol weight ratio:6, mixture is added to 80-90% ethanol formation mixed liquor, mixed liquor is soaked
Bubble is filtered after 72-120 hours, collects filtrate, then filtrate is concentrated, and powder is prepared according to a conventional method.
Embodiment 6
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：Sophora flower be 45 parts,
Garden burnet is 25 parts, Artemisia japonica is 20 parts, Radix Codonopsis is 20 parts and honeysuckle is 18 parts.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：Sophora flower is 45 parts, garden burnet is 25 parts, Artemisia japonica is 20
Part, Radix Codonopsis be 20 parts and honeysuckle be 18 parts mix by weight after smash to 80-100 mesh formation mixture；According to
Mixture is 1 with ethanol weight ratio:8, mixture is added to 80-90% ethanol formation mixed liquor, mixed liquor is soaked
Bubble is filtered after 72-120 hours, collects filtrate, then filtrate is concentrated, and powder is prepared according to a conventional method.
Embodiment 7
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：Sophora flower be 45 parts,
Garden burnet is 25 parts, Artemisia japonica is 20 parts, Radix Codonopsis is 20 parts and honeysuckle is 18 parts.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：Sophora flower is 45 parts, garden burnet is 25 parts, Artemisia japonica is 20
Part, Radix Codonopsis be 20 parts and honeysuckle be 18 parts mix by weight after smash to 80-100 mesh formation mixture；According to
Mixture is 1 with ethanol weight ratio:7, mixture is added to 80-90% ethanol formation mixed liquor, mixed liquor is soaked
Bubble is filtered after 72-120 hours, collects filtrate, then filtrate is concentrated, and powder is prepared according to a conventional method.
Comparative example 1
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：20 parts of sophora flower,
10 parts of 60 parts of elm, 15 parts of Artemisia japonica, 40 parts of Radix Codonopsis and honeysuckle.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：20 parts of sophora flower, 60 parts of garden burnet, 15 parts of Artemisia japonica, party
10 parts of 40 parts of ginseng and honeysuckle are smashed after mixing by weight to 80-100 mesh formation mixture；According to mixture and second
Alcohol weight ratio is 1:6, mixture is added to 80-90% ethanol formation mixed liquor, it is small that mixed liquor is carried out into immersion 72-120
When after filtered, collect filtrate, then filtrate concentrated, powder is prepared according to a conventional method.
Comparative example 2
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：35 parts of sophora flower,
15 parts of 40 parts of elm, 20 parts of Artemisia japonica, 16 parts of Radix Codonopsis and honeysuckle.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：35 parts of sophora flower, 40 parts of garden burnet, 20 parts of Artemisia japonica, party
15 parts of 16 parts of ginseng and honeysuckle are smashed after mixing by weight to 80-100 mesh formation mixture；According to mixture and second
Alcohol weight ratio is 1:1.5, mixture is added to 80-90% ethanol formation mixed liquor, mixed liquor is subjected to immersion 72-120
Filtered after hour, collect filtrate, then filtrate is concentrated, powder is prepared according to a conventional method.
Comparative example 3
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：35 parts of sophora flower,
15 parts of 40 parts of elm, 20 parts of Artemisia japonica, 16 parts of Radix Codonopsis and honeysuckle.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：35 parts of sophora flower, 40 parts of garden burnet, 20 parts of Artemisia japonica, party
15 parts of 16 parts of ginseng and honeysuckle are smashed after mixing by weight to 50-70 mesh formation mixture；According to mixture and ethanol
Weight ratio is 1:6, mixture is added to 80-90% ethanol formation mixed liquor, mixed liquor is subjected to immersion 72-120 hours
Filtered afterwards, collect filtrate, then filtrate is concentrated, powder is prepared according to a conventional method.
Comparative example 4
A kind of formula for the Chinese medicine composition for preventing and treating chicken coccidiasis：Fraction meter by weight, raw material includes：35 parts of sophora flower,
15 parts of 40 parts of elm, 20 parts of Artemisia japonica, 16 parts of Radix Codonopsis and honeysuckle.
A kind of preparation method for the Chinese medicine composition for preventing and treating chicken coccidiasis：35 parts of sophora flower, 40 parts of garden burnet, 20 parts of Artemisia japonica, party
15 parts of 16 parts of ginseng and honeysuckle are smashed after mixing by weight to 80-100 mesh formation mixture；According to mixture and second
Alcohol weight ratio is 1:6, mixture is added to 40-50% ethanol formation mixed liquor, it is small that mixed liquor is carried out into immersion 72-120
When after filtered, collect filtrate, then filtrate concentrated, powder is prepared according to a conventional method.
Experimental example 1
1 similar and good week old broiler chicks of 260 health degrees are chosen, is divided into 13 groups, every group 20, is set to experiment
Group 1-13；Experimental group 1-12 is inoculated with purebred E. pubescens Msxim 50000 respectively, and experimental group 13 is not processed；Respectively
The Chinese medicine composition for the preventing and treating chicken coccidiasis that administration embodiment 1-7 and comparative example 1-4 to experimental group 1-11 are provided, to experimental group
12 apply the Chinese medicine composition of the commercially available preventing and treating chicken coccidiasis of equivalent；Under the same conditions, raising experiment group 1-13 chick
To 4 week old, weigh in the 28th age in days, catch and kill, observation caecum lesion situation is simultaneously scored, while taking cecal content to determine OPG
Value (caecum unrest capsule number), effect of the Chinese medicine composition to chicken coccidiasis of preparation of the invention is evaluated by treating index.
Anticoccidial index (ACI), using the criterion calculation anticoccidial index of Merck ＆ Co., Inc.：Anticoccidial index (ACI)=
(body weight increase rate+survival rate)-(pathological changes value+warm capsule value).Drug effect criterion is：ACI is less than 120, sentences weak curative effect；ACI is
120-160, curative effect is medium；ACI is 160-180, and curative effect is good；ACI is more than 180, sentences curative effect outstanding.Wherein, body weight increase rate
(%)=average weight gain of inoculation medication group/is not inoculated with average weight gain × 100% with not medication group；Survival rate (%)=(group
Interior total chicken number-every group is because of the dead chicken number of infection chicken coccidiasis)/group in total chicken number × 100%；The 4th day extremely after coccidium infection
Excrement is collected in 8 days in ground, every gram of excrement egg sac number (OPG) is calculated according to McMaster ' s methods, according to OPG values.By the following method
The warm capsule value of conversion, when OPG is 0-0.1, oocyst value is 0；When OPG is 0.11-1.0, oocyst value is 1；When OPG is 1.1-1.9,
Oocyst value is 10；When OPG is 2.0-5.9, oocyst value is 20；When OPG is 6.0-10.9, oocyst value is 30；When OPG >=11.0
When, oocyst value is 40；Pathological changes value=every group of average lesion scores × 10.
Lesion is scored, and is scored according to the order of severity of cut open inspection rear intestinal lesion：0 point, no naked eyes lesion；1 point, caecum wall has
The addiction point being seldom dispersed in, intestinal wall is not thickened, and content is normal；2 points, lesion increasing number, cecal content is substantially with blood, caecum
Wall is thick slightly, and content is normal；3 points, there are volume blood and intestines core, the caseous Banana Type of the visible canescence of blood clot in caecum
Block, caecum wall is substantially thickened, and manure content is few in caecum；4 points, substantial amounts of blood and intestines core are full of in caecum, caecum swells
Greatly, excrement slag is contained in intestines core or is free of, because the dead chicken of coccidium infection is also denoted as 4 points.
Record the results are shown in Table shown in 1：
Table 1
From the data in table 1, it can be seen that obviously, experimental group 1-11 ACI is all higher than 190, as outstanding；The ACI of experimental group 13 is small
It is good, the result shows in 180, the Chinese medicine composition tool that raw material provided by the present invention and preparation method are prepared
There is excellent preventing and treating chicken coccidiasis.
Experimental group 1-5 ACI values are more than the ACI of experimental group 8 only, raw material that experimental group 8 and experimental group 1-5 are used and
Preparation method is identical, and each raw material proportioning of experimental group 8 is different, and the result shows, when using sophora flower 35-55 parts, garden burnet 40-50
When part, 20-28 parts of Artemisia japonica, the ratio range of 15-20 parts of 16-25 parts of Radix Codonopsis and honeysuckle, the Chinese traditional medicine composition prepared
The drug effect of thing is more abundant, and prevention effect is more preferable；The ACI values of experimental group 5 are more than test group 1-4, thus illustrate, when sophora flower is 40
Part, garden burnet be 45 parts, Artemisia japonica be 25 parts, Radix Codonopsis is 20 parts and honeysuckle is 18 parts, the preventing and treating chicken of obtained Chinese medicine composition
The effect of global-worm illness is best.
Experimental group 5-7 ACI values are more than experimental group 9, and the ACI values of experimental group 7 are more than experimental group 5 and 6, experimental group 7
Each raw material and its proportioning and preparation method are identical with experimental group 5 and 6, illustrate, when the weight ratio of mixture and ethanol is 1:6-8
When, the effect of the preventing and treating chicken coccidiasis of obtained Chinese medicine composition is best.
The ACI values of test group 1 are more than the ACI values of experimental group 10, and the raw material and proportioning of experimental group 10 and experimental group 1 are homogeneous
Together, the result shows, mixture is being crushed into 80-100 mesh, and its drug effect plays maximum, and active ingredient is most, obtained Chinese medicine
The effect of the preventing and treating chicken coccidiasis of composition is best.
The ACI values of test group 1 are more than the ACI values of experimental group 11, and the raw material and proportioning of experimental group 11 and experimental group 1 are homogeneous
Together, the result shows, when concentration of alcohol is 80-90%, and the effect of the preventing and treating chicken coccidiasis of obtained Chinese medicine composition is best.
In summary, the Chinese medicine composition of preventing and treating chicken coccidiasis provided in an embodiment of the present invention, the traditional Chinese medicine composition for treating
The excellent effect of chicken coccidiasis, and drug resistance will not be produced, also have no toxic side effect, be difficult to remain in poultry body；Prevent and treat chicken ball
The preparation method of the Chinese medicine composition of parasitosis is simple and easy to apply, and operation is reliable, can prepare in preventing and treating chicken coccidiasis excellent performance
Drug composition.
Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (7)
1. a kind of Chinese medicine composition for preventing and treating chicken coccidiasis, it is characterized in that：Count by weight, its raw material includes：Sophora flower 35-55
15-20 parts of part, 40-50 parts of garden burnet, 20-28 parts of Artemisia japonica, 16-25 parts of Radix Codonopsis and honeysuckle.
2. the Chinese medicine composition of preventing and treating chicken coccidiasis according to claim 1, it is characterized in that：Count by weight, it is described
Sophora flower is 38-52 parts, the garden burnet is 42-48 parts, the Artemisia japonica is 22-26 parts, the Radix Codonopsis is 18-22 parts and described
Honeysuckle is 16-19 parts.
3. the Chinese medicine composition of preventing and treating chicken coccidiasis according to claim 1, it is characterized in that：Count by weight, it is described
Sophora flower is 40 parts, the garden burnet is 45 parts, the Artemisia japonica is 25 parts, the Radix Codonopsis is 20 parts and the honeysuckle is 18 parts.
4. the Chinese medicine composition of preventing and treating chicken coccidiasis according to claim 1, it is characterized in that：The agent of the Chinese medicine composition
Type includes powder, granule or oral liquid.
5. a kind of preparation method of the Chinese medicine composition of preventing and treating chicken coccidiasis as described in claim any one of 1-4, its feature
It is：
Smashed after sophora flower, garden burnet, Artemisia japonica, Radix Codonopsis and honeysuckle are mixed by the parts by weight to 80-100 mesh and form mixed
Compound；The mixture is added to 80-90% ethanol formation mixed liquor, the mixed liquor is subjected to immersion 72-120 hours
Filtered afterwards, collect filtrate, then filtrate is concentrated.
6. the preparation method of the Chinese medicine composition of preventing and treating chicken coccidiasis according to claim 5, it is characterized in that：The mixing
The weight ratio of thing and the ethanol is 1:6-8.
7. the preparation method of the Chinese medicine composition of preventing and treating chicken coccidiasis according to claim 5, it is characterized in that：Concentration is described
The relative density of filtrate to the filtrate is 1.2-1.4g/ml.
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