CN104398612A - Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof Download PDF

Info

Publication number
CN104398612A
CN104398612A CN201410628044.9A CN201410628044A CN104398612A CN 104398612 A CN104398612 A CN 104398612A CN 201410628044 A CN201410628044 A CN 201410628044A CN 104398612 A CN104398612 A CN 104398612A
Authority
CN
China
Prior art keywords
radix
chinese medicine
medicine composition
parts
crude drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201410628044.9A
Other languages
Chinese (zh)
Other versions
CN104398612B (en
Inventor
李艳飞
曹峥
李心慰
王凡
王红
徐飞博
杨旭
庄翠翠
胡瑞鸿
袁明霞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northeast Agricultural University
Original Assignee
Northeast Agricultural University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northeast Agricultural University filed Critical Northeast Agricultural University
Priority to CN201410628044.9A priority Critical patent/CN104398612B/en
Publication of CN104398612A publication Critical patent/CN104398612A/en
Application granted granted Critical
Publication of CN104398612B publication Critical patent/CN104398612B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine composition for treating chicken coccidiosis and a preparation method thereof. The composition comprises Chinese pulsatilla root, kudzu vine root, dark plum, garden burnet, fructus forsythiae, phyllanthus urinaria, honeysuckle flower, and banksia rose. The preparation method comprises the following steps: (1) weighing the raw materials mentioned above; (2) adding water to soak the raw materials, then decocting the raw materials in water, filtering the decoction, and saving the filtrate for later use; (3) decocting the dregs with water, filtering, and saving the filtrate; (4) merging the two filtrates so as to obtain the composition. The traditional Chinese medicine composition has the functions of clearing heat, removing toxicity, killing insects, dispelling evil, stopping bleeding, cooling blood, stopping dysentery, alleviating water retention, invigorating stomach, and promoting digestion, is capable of prominently improving the disease resistant performance and immunity of chickens, has a definite curative effect on chicken coccidiosis caused by infection of eimeria coccidium or mixed infection of a plurality of eimeria coccidiums, has a high cure rate, and does not have any side or toxic effect. The relapse rate is zero, and the weight gain and egg yield are not affected the recovery.

Description

Chinese medicine composition for the treatment of chicken coccidiosis and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of poultry disease, particularly relate to a kind of Chinese medicine composition for the treatment of chicken coccidiosis, the invention further relates to the method preparing described Chinese medicine composition, belong to the treatment by Chinese herbs field of chicken coccidiosis.
Background technology
Chicken coccidiosis is the caecum and the small intestinal that are parasitized chicken by one or more coccidiosiss of Eimeria, causes to suffer from diarrhoea, has blood in stool, parasitic disease that loss of appetite, lassitude, anemia are cardinal symptom.This disease can occur the whole year, but is multiplely born in rainy sultry season, and be epidemic season to 9 the end of month from early April, August is the most serious.12-60 Japanese instar chickling and young chicken are to primary disease susceptible, and sickness rate reaches 80%, and case fatality rate can reach 30%, and the chick growth of recovering is obstructed, and feed conversion rate declines, and egg laying performance reduces.The poultry husbandry economic loss that the annual whole world is caused because of chicken coccidiosis and the expense for preventing and treating this disease reach multi-million dollar, have a strong impact on the economic benefit of poultry husbandry.
It is reported, there are 9 kinds of Eimeria coccidiosiss parasitizing chicken in the whole world, and also there is distribution in China, wherein the highest with the infection rate of Eimeria tenella and heap-type Eimeria, and is mostly several coccidiosis mixed infection in producing.Prolonged application antibiotic and chemical synthetic drug control chicken coccidiosis, not only make the strain of drug resistance worm constantly occur, and cause that the chemicals of poultry product is residual to exceed standard and environmental pollution.Therefore, in the urgent need to developing a kind of toxic and side effects coccidiostat that is little, that remain without hazardous drugs.Research shows, but Chinese herbal medicine has the effect of worm of killing, and toxic and side effects is low, use safety, noresidue, and coccidiosis not easily produces drug resistance, has the immunologic function strengthening chicken in addition, improves the advantages such as fertility performance.Up to now, Chinese medicine composition disclosed in document only has definite curative effect for infecting by a kind of Eimeria the chicken coccidiosis caused, for the defect that the chicken coccidiosis existence curative effect in various degree caused by multiple Eimeria mixed infection is definite not; Therefore, develop a kind of Chinese medicine composition for being had definite curative effect by a kind of Eimeria coccidium infection or the chicken coccidiosis caused by the mixed infection of multiple Eimeria coccidiosis, the sound development for poultry husbandry has far reaching significance.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for being had definite curative effect by a kind of Eimeria coccidium infection or the chicken coccidiosis caused by the mixed infection of multiple Eimeria coccidiosis, this Chinese medicine composition is high to the cure rate being infected the chicken coccidiosis caused by one or more Eimerias, more do not recur after, without any side effects and preparation cost is cheap.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
First the present invention discloses a kind of Chinese medicine composition for the treatment of chicken coccidiosis, comprises following crude drug and makes: the Radix Pulsatillae, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Flos Lonicerae and the Radix Aucklandiae; The weight portion of each component is: Radix Pulsatillae 60-90 part, Fructus Mume 50-70 part, Radix Sanguisorbae 50-70 part, Fructus Forsythiae 50-60 part, Flos Lonicerae 30-40 part and Radix Aucklandiae 20-30 part;
Preferably, the weight portion of each crude drug is: the Radix Pulsatillae 70 parts, Fructus Mume 60 parts, Radix Sanguisorbae 60 parts, Fructus Forsythiae 50 parts, Flos Lonicerae 30 parts and the Radix Aucklandiae 20 parts.
The Radix Pulsatillae: be the dry root of the ranunculaceae plant Radix Pulsatillae.Nature and flavor are bitter, cold.Return stomach, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For toxic-heat and blood stasis, pudendal pruritus leukorrhagia, amebic dysentery.
Fructus Mume: be the dry immature fruit of rose department plant plum.Nature and flavor acid, temperature.Enter liver, spleen, lung, large intestine channel.Function cures mainly: convergence is promoted the production of body fluid, relieving colic caused by ascaris anthelmintic.Control chronic cough, deficiency-heat excessive thirst, chronic malaria, chronic diarrhea, dysentery, has blood in stool, hematuria, metrorrhagia, and the ascariasis of biliary tract is suffered from abdominal pain, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.
Radix Sanguisorbae: be the root and rhizome of rosaceous plant Radix Sanguisorbae.Nature and flavor picric acid, cold.Nontoxic.Enter liver, large intestine channel.Function cures mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Function cures mainly: spit blood, epistaxis, dysentery, metrorrhagia, carbuncle, eczema, incised wound, burn.
Fructus Forsythiae: be the fruit of Oleaceae plants Fructus Forsythiae.Nature and flavor are bitter, cool.Enter the heart, liver, gallbladder meridian.Function cures mainly: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.
Flos Lonicerae: be the alabastrum of caprifoliaceae plant Radix Ophiopogonis.Nature and flavor are sweet, cold.Enter lung, stomach warp.Function cures mainly: heat clearing away, removing toxic substances.
The Radix Aucklandiae: be the root of feverfew Saussurea lappa Clarke, vladimiria denticulata Ling, Radix Vladimiriae etc.Nature and flavor are worked hard, temperature.Enter lung, liver, spleen channel.Function cures mainly: circulation of qi promoting is stopped blooding, warming middle-JIAO for easing the stomach.
Chinese medicine composition of the present invention has that heat-clearing and toxic substances removing, parasite killing are eliminating evil, effect of hemostasis removing heat from blood, dysentery relieving diuretic, invigorating the stomach and promoting digestion, effectively can resist and infect by multiple Eimerias such as Eimeria tenella, heap-type Eimeria and Eimeria maximas the mixed infection caused, the resistance of remarkable enhancing chicken and immunity, cure rate is high, does not recur, has no side effect more.
The invention also discloses a kind of Chinese medicine composition for the treatment of chicken coccidiosis, comprise following crude drug: the Radix Pulsatillae, Radix Puerariae, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Herba Phyllanthi Urinariae, Flos Lonicerae and the Radix Aucklandiae; Preferably, the weight portion of each crude drug is: Radix Pulsatillae 60-90 part, Radix Puerariae 30-50 part, Fructus Mume 50-70 part, Radix Sanguisorbae 50-70 part, Fructus Forsythiae 50-60 part, Herba Phyllanthi Urinariae 40-50 part, Flos Lonicerae 30-40 part and Radix Aucklandiae 20-30 part;
Preferred, the weight portion of each crude drug is: the Radix Pulsatillae 70 parts, Radix Puerariae 40 parts, Fructus Mume 60 parts, Radix Sanguisorbae 60 parts, Fructus Forsythiae 50 parts, Herba Phyllanthi Urinariae 40 parts, Flos Lonicerae 30 parts and the Radix Aucklandiae 20 parts.
Radix Puerariae: be the tuber of leguminous plant Pueraria lobota.Nature and flavor are sweet pungent, flat.Enter spleen, stomach warp.Function cures mainly: yang invigorating expelling pathogenic factors from muscles, and rash antidiarrheal, relieving restlessness is quenched the thirst.
Herba Phyllanthi Urinariae: be herb or the whole herb with root of euphorbia plant Cacumen Securinegae Suffruticosae.Nature and flavor sweetness and bitterness, cool.Enter liver, lung two warp.Function cures mainly: calming liver and clearing heat, promoting diuresis to remove toxic substance.
The present invention with the addition of following seven groups of medicines respectively on the basis of the Radix Pulsatillae, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Flos Lonicerae and the Radix Aucklandiae: (1) Radix Puerariae and Herba Phyllanthi Urinariae; (2) Herba Portulacae and Radix Scutellariae; (3) Bin youth and Rhizoma Coptidis; (4) Radix Astragali and Radix Glycyrrhizae; (5) Semen Cucurbitae and the Radix Paeoniae Alba; (6) Radix Isatidis and Flos Sophorae; (7) Radix Et Rhizoma Rhei and Herba Euphorbiae Humifusae; Above-mentioned seven groups of pharmaceutical compositions are prepared medicinal liquid respectively, investigates its therapeutic effect to the chicken that catches an illness of Eimeria tenella, heap-type Eimeria and Eimeria maxima mixed infection.Experimental result shows: the Chinese medicine composition adding Radix Puerariae and Herba Phyllanthi Urinariae on the Radix Pulsatillae, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Flos Lonicerae and Radix Aucklandiae basis up to 98.0%, is significantly higher than other combination to the cure rate of the chicken that catches an illness of Eimeria tenella, heap-type Eimeria and Eimeria maxima mixed infection.Experimental result illustrates, the Radix Pulsatillae, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Flos Lonicerae, the Radix Aucklandiae have significant Synergistic effect with Radix Puerariae together with Herba Phyllanthi Urinariae after compatibility, significantly improve the cure rate to the chicken coccidiosis that multiple Eimeria mixed infection causes.
The result of practical application of traditional Chinese medicine composition for treating chicken coccidiosis of the present invention shows, the chicken coccidiosis determined curative effect that Chinese medicine composition of the present invention causes one or more Eimeria mixed infections, and cure rate all reaches more than 98%, is up to 99.1%; Cure after one week or two weeks, stool examination does not find coccidian oocyst; Ill chicken rate of body weight gain or laying rate more after all uninfluenced, follow up a case by regular visits to laying hen eliminate have no recurrence.
The present invention further discloses a kind of method preparing described Chinese medicine composition, comprise the following steps:
(1) each crude drug is taken according to described proportioning;
(2) decoct after soaking in crude drug, decoction liquor filtered, filtrate is for subsequent use;
(3) add water in medicinal residues and decoct, filter, get filtrate;
(4) filtrate of combining step (2) and step (3), to obtain final product.
Wherein, preferably, decoct after adding the water soaking of 3-6 times of quality in step (2) in crude drug; Described soak time is preferably 20-40 minute, is more preferably 30 minutes; Described decocting time is preferably 35-45 minute.
Preferably, the water adding 3-5 times of quality in step (3) in medicinal residues decocts; Described decocting time is preferably 30-40 minute.
The using method of Chinese medicine composition of the present invention is as follows:
Dosage Chinese medicine composition of the present invention being pressed 3-5mL/ plumage and feedstuff or drink water mixes, and suffer from chicken and freely take food or drink, every day 2 times, the meal with wine state of an illness is used in conjunction 3-5 days; Take the circumstances into consideration to add and subtract each component dosage within the scope of recipe requirements according to the state of an illness and the large I of body weight.
If it is less to suffer from chicken feed intake and amount of drinking water, also can takes the circumstances into consideration to add and subtract dosage according to body weight size within the scope of recipe requirements and gavage; After feed intake and amount of drinking water are recovered, then Chinese medicine composition and feedstuff or drink water is mixed, suffer from chicken and freely take food or drink.
Technical solution of the present invention compared with prior art has following beneficial effect:
(1) in Chinese medicine composition of the present invention, each Component Source is extensive, with low cost;
(2) Chinese medicine composition of the present invention is to being infected the chicken coccidiosis determined curative effect caused by one or more Eimerias, and cure rate all reaches more than 98%, is up to 99.1%; More do not recur after, have no side effect; And ill chicken rate of body weight gain or laying rate are rear unaffected.
(3) easy to use, Chinese medicine composition of the present invention and feedstuff or drink water is mixed, suffers from chicken and freely take food or drink.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.It should be understood that described embodiment is only exemplary, any restriction is not formed to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments or replacement all fall into protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine composition
Each crude drug (g) is taken: the Radix Pulsatillae 60, Fructus Mume 50, Radix Sanguisorbae 50, Fructus Forsythiae 50, Flos Lonicerae 30 and the Radix Aucklandiae 20 according to following weight;
Add in 3500mL water according to described proportioning by above-mentioned all crude drug, soak 30 minutes, slow fire boiling 35 minutes, elimination medicinal residues obtain medicinal liquid and are about 500mL excessively; In the medicinal residues after filtration, add 3000mL water, slow fire boiling 30 minutes again, filter medicinal liquid is about 500mL, merge the medicinal liquid of twice, to obtain final product.
The preparation of embodiment 2 Chinese medicine composition
Each crude drug (g) is taken: the Radix Pulsatillae 90, Fructus Mume 70, Radix Sanguisorbae 70, Fructus Forsythiae 60, Flos Lonicerae 40 and the Radix Aucklandiae 30 according to following weight;
Add in 4000mL water according to described proportioning by above-mentioned all crude drug, soak 30 minutes, slow fire boiling 45 minutes, elimination medicinal residues obtain medicinal liquid and are about 500mL excessively; In the medicinal residues after filtration, add 3500mL water, slow fire boiling 40 minutes again, filter medicinal liquid is about 500mL, merge the medicinal liquid of twice, to obtain final product.
The preparation of embodiment 3 Chinese medicine composition
Each crude drug (g) is taken: the Radix Pulsatillae 70, Fructus Mume 60, Radix Sanguisorbae 60, Fructus Forsythiae 50, Flos Lonicerae 30 and the Radix Aucklandiae 20 according to following weight;
Add in 3800mL water according to described proportioning by above-mentioned all crude drug, soak 20 minutes, slow fire boiling 40 minutes, elimination medicinal residues obtain medicinal liquid and are about 500mL excessively; In the medicinal residues after filtration, add 3200mL water, slow fire boiling 35 minutes again, filter medicinal liquid is about 500mL, merge the medicinal liquid of twice, to obtain final product.
The preparation of embodiment 4 Chinese medicine composition
Each crude drug (g) is taken: the Radix Pulsatillae 60, Radix Puerariae 30, Fructus Mume 50, Radix Sanguisorbae 50, Fructus Forsythiae 50, Herba Phyllanthi Urinariae 40, Flos Lonicerae 30 and the Radix Aucklandiae 20 according to following weight;
Add in 3600mL water according to described proportioning by above-mentioned all crude drug, soak 35 minutes, slow fire boiling 35 minutes, elimination medicinal residues obtain medicinal liquid and are about 500mL excessively; In the medicinal residues after filtration, add 3600mL water, slow fire boiling 35 minutes again, filter medicinal liquid is about 500mL, merge the medicinal liquid of twice, to obtain final product.
The preparation of embodiment 5 Chinese medicine composition
Each crude drug (g) is taken: the Radix Pulsatillae 90, Radix Puerariae 50, Fructus Mume 70, Radix Sanguisorbae 70, Fructus Forsythiae 60, Herba Phyllanthi Urinariae 50, Flos Lonicerae 40 and the Radix Aucklandiae 30 according to following weight;
Add in 4000mL water according to described proportioning by above-mentioned all crude drug, soak 40 minutes, slow fire boiling 45 minutes, elimination medicinal residues obtain medicinal liquid and are about 500mL excessively; In the medicinal residues after filtration, add 3500mL water, slow fire boiling 40 minutes again, filter medicinal liquid is about 500mL, merge the medicinal liquid of twice, to obtain final product.
The preparation of embodiment 6 Chinese medicine composition
Each crude drug (g) is taken: the Radix Pulsatillae 70, Radix Puerariae 40, Fructus Mume 60, Radix Sanguisorbae 60, Fructus Forsythiae 50, Herba Phyllanthi Urinariae 40, Flos Lonicerae 30 and the Radix Aucklandiae 20 according to following weight;
Add in 3800mL water according to described proportioning by above-mentioned all crude drug, soak 30 minutes, slow fire boiling 45 minutes, elimination medicinal residues obtain medicinal liquid and are about 500mL excessively; In the medicinal residues after filtration, add 3500mL water, slow fire boiling 40 minutes again, filter medicinal liquid is about 500mL, merge the medicinal liquid of twice, to obtain final product.
The different Chinese medicine composition of experimental example 1 is tested the therapeutic effect of chicken coccidiosis
1, experimental technique
Chinese medicine composition 1, takes each crude drug (g) according to following weight: the Radix Pulsatillae 70, Fructus Mume 60, Radix Sanguisorbae 60, Fructus Forsythiae 50, Flos Lonicerae 30 and the Radix Aucklandiae 20;
Add in 3500 water according to described proportioning by above-mentioned all crude drug, soak 30 minutes, slow fire boiling 45 minutes, elimination medicinal residues obtain medicinal liquid and are about 500mL excessively; In the medicinal residues after filtration, add 3500mL water, slow fire boiling 40 minutes again, filter medicinal liquid is about 500mL, merge the medicinal liquid of twice, to obtain final product.
Chinese medicine composition 2: add Radix Puerariae 40g, Herba Phyllanthi Urinariae 40g on Chinese medicine composition 1 basis;
Chinese medicine composition 3: add Herba Portulacae 40g, Radix Scutellariae 40g on Chinese medicine composition 1 basis;
Chinese medicine composition 4: add Bin youth 40g, Rhizoma Coptidis 40g on Chinese medicine composition 1 basis;
Chinese medicine composition 5: add Radix Astragali 40g, Radix Glycyrrhizae 40g on Chinese medicine composition 1 basis;
Chinese medicine composition 6: add Semen Cucurbitae 40g, Radix Paeoniae Alba 40g on Chinese medicine composition 1 basis;
Chinese medicine composition 7: add Radix Isatidis 40g, Flos Sophorae 40g on Chinese medicine composition 1 basis;
Chinese medicine composition 8: add Radix Et Rhizoma Rhei 40g, Herba Euphorbiae Humifusae 40g on Chinese medicine composition 1 basis;
The preparation method of each Traditional Chinese medicine composition liquid medicine is with Chinese medicine composition 1.
1-8 group is divided at random by the chicken that catches an illness of Eimeria tenella, heap-type Eimeria and Eimeria maxima mixed infection by through being diagnosed as, often organize 100, respectively the fluid temperature of 8 of above-mentioned preparation groups of Chinese medicine compositions is down to 20-30 DEG C, mix with drinking-water by the dosage of 4mL/ plumage, often group trouble chicken is freely drunk, every day 2 times, be used in conjunction 5 days, add up each group of cure rate.
2, experimental result
Statistical result is in table 1.
Table 1 different traditional Chinese medicine composition for treating chicken coccidiosis statistical effect result
Experimental result shows, at Chinese medicine composition 1 (Radix Pulsatillae 70g, Fructus Mume 60g, Radix Sanguisorbae 60g, Fructus Forsythiae 50g, Flos Lonicerae 30g and Radix Aucklandiae 20g) basis on add Radix Puerariae 40g, the Chinese medicine composition 2 of Herba Phyllanthi Urinariae 40g is to by Eimeria tenella, the cure rate of the chicken that catches an illness of heap-type Eimeria and Eimeria maxima mixed infection is up to 98.0%, be significantly higher than other combination, the Radix Pulsatillae is described, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Flos Lonicerae, the Radix Aucklandiae and Radix Puerariae, there is between Herba Phyllanthi Urinariae significant synergistic function, its compatibility significantly can be promoted together its cure rate to the chicken coccidiosis caused by the mixed infection of multiple Eimeria coccidiosis, by contrast, after together with the Radix Pulsatillae, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Flos Lonicerae, the Radix Aucklandiae and other 6 groups of medication medication compatibilities, for the cure rate of the chicken coccidiosis caused by the mixed infection of multiple Eimeria coccidiosis there are no obvious lifting.
The practical application of experimental example 2 traditional Chinese medicine composition for treating chicken coccidiosis of the present invention
The a certain raiser in Shangzhi City, Heilongjiang Province raises 300 plumage 18 Japanese instar chicklings.In mid-July, 2009, occur that spirit is depressed, feather is fluffy, and head is crispaturaed, loss of appetite, arranges red medicated porridge sample feces symptom, 59 plumages of dying off in 3 days.Through autopsy examination and coccidiosis qualification, be diagnosed as the chicken coccidiosis caused by Eimeria tenella, heap-type Eimeria and Eimeria maxima mixed infection.
The dosage pressing 4mL/ plumage with Chinese medicine composition prepared by the embodiment of the present invention 6 mixes with drinking-water, suffers from chicken and freely drinks, every day 2 times, serve on 4 days.Mainly after medication state symptom and namely alleviate, dead 4 plumages, wherein 2 plumages are dead in the first day for the treatment of, and medication cure rate is 98.3%.After curing one week, stool examination does not find coccidian oocyst.
The practical application of experimental example 3 traditional Chinese medicine composition for treating chicken coccidiosis of the present invention
Harbin, Heilongjiang Province plant raises 1-2 monthly age chickling 1749 plumage, and spirit is depressed about to have the chickling of 1/6th to occur in chick house on June 29th, 2011, loss of appetite, and feather is fluffy, visual mucosal pallor, diarrhoea, the clinical symptoms of hemafecia.Use Amprolium treatment without obvious curative effects, end July 1, chickling phase secondary disease in chick house, dead 319 plumages.Be the chicken coccidiosis caused by Eimeria tenella and the mixed infection of heap-type Eimeria after diagnosing.
With the embodiment of the present invention 6 prepare Chinese medicine composition treat, because of suffer from chicken feed intake and amount of drinking water less, gavage by the dosage of 4mL/ plumage, every day 2 times, after serveing on 2 days, most sick chicken is clearly better and feed intake and amount of drinking water recover to some extent; The dosage then pressing 5mL/ plumage mixes with feedstuff, suffers from chicken and freely takes food, and within 5 days, recovers normal afterwards.
Treat 1430 ptilosis chickens altogether, cure 1402 plumages, dead 28 plumages, cure rate is 98.0%.After curing two weeks, stool examination does not find coccidian oocyst, and rate of body weight gain is uninfluenced, follows up a case by regular visits to and has no recurrence to laying hen is superseded.
The practical application of experimental example 4 traditional Chinese medicine composition for treating chicken coccidiosis of the present invention
In July, 2013, Mudanjiang City of Heilongjiang Province raiser, there is lethargy in 278 plumage 50 age in days Gallus Domesticuss of raising, feather fluffy in succession, slow-witted vertical, and wing is big-eared to hang down, and is polluted, the symptom of visual mucosal pallor and hemafecia, dead 107 plumages in 3 days around cloaca by loose stool.Positive effect is had no with moroxydine and oxytetracycline treatment.Through being diagnosed as the chicken coccidiosis caused by Eimeria tenella, Eimeria maxima, precocious Eimeria and Eimeria Necatrix mixed infection.
By traditional Chinese medicine composition for treating prepared by the embodiment of the present invention 6, mix with drinking-water by the dosage of 5mL/ plumage, suffer from chicken and freely drink, every day 2 times, serve on 5 days.Sick chicken spirit, appetite recover normal, and discharge without hemafecia, stopping of having loose bowels in the 3rd day, fully recovers after taking medicine continuously 5 days.
Treat disease chicken 171 plumage altogether, cure 169 plumages, cure rate reaches 98.8%.After curing two weeks, stool examination does not find coccidian oocyst.
The practical application of experimental example 5 traditional Chinese medicine composition for treating chicken coccidiosis of the present invention
The a certain raiser in Harbin, Heilongjiang Province raises 400 plumage 18 Japanese instar chicklings.In mid-June, 2013, occur that spirit is depressed, feather is fluffy, loss of appetite, arranges red medicated porridge sample feces symptom, 68 plumages of dying off in 3 days.Through autopsy examination and coccidiosis qualification, be diagnosed as the chicken coccidiosis caused by Eimeria Tenella Infection.
The dosage pressing 4mL/ plumage immediately with Chinese medicine composition prepared by the embodiment of the present invention 6 mixes with drinking-water, suffers from chicken and freely drinks, every day 2 times, serve on 4 days.Mainly after medication state symptom and namely alleviate, dead 3 plumages, wherein 2 plumages are dead in the first day for the treatment of, and medication cure rate is 99.1%.After curing one week, stool examination does not find coccidian oocyst.
The practical application of experimental example 6 traditional Chinese medicine composition for treating chicken coccidiosis of the present invention
In June, 2013, there is lethargy in the 388 plumage 50 age in days Gallus Domesticuss that Mudanjiang City of Heilongjiang Province raiser raises, feather fluffy and disorderly in succession, slow-witted vertical, and wing is big-eared to hang down, and is polluted, visual mucosal pallor and hemafecia symptom, dead 98 plumages in 3 days around cloaca by loose stool.Through being diagnosed as the chicken coccidiosis caused by the infection of heap-type Eimeria.
By traditional Chinese medicine composition for treating prepared by the embodiment of the present invention 6, mix with drinking-water by the dosage of 5mL/ plumage, suffer from chicken and freely drink, every day 2 times, serve on 5 days.Sick chicken spirit, appetite recover normal, and discharge without hemafecia, stopping of having loose bowels in the 3rd day, fully recovers after taking medicine continuously 5 days.
Treat disease chicken 290 plumage altogether, cure 285 plumages, cure rate reaches 98.3%.After curing two weeks, stool examination does not find coccidian oocyst.

Claims (10)

1. treat a Chinese medicine composition for chicken coccidiosis, it is characterized in that, be made up of following crude drug: the Radix Pulsatillae, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Flos Lonicerae and the Radix Aucklandiae.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each crude drug is: Radix Pulsatillae 60-90 part, Fructus Mume 50-70 part, Radix Sanguisorbae 50-70 part, Fructus Forsythiae 50-60 part, Flos Lonicerae 30-40 part and Radix Aucklandiae 20-30 part.
3. according to Chinese medicine composition according to claim 2, it is characterized in that, the weight portion of each crude drug is: the Radix Pulsatillae 70 parts, Fructus Mume 60 parts, Radix Sanguisorbae 60 parts, Fructus Forsythiae 50 parts, Flos Lonicerae 30 parts and the Radix Aucklandiae 20 parts.
4. treat a Chinese medicine composition for chicken coccidiosis, it is characterized in that, be made up of following crude drug: the Radix Pulsatillae, Radix Puerariae, Fructus Mume, Radix Sanguisorbae, Fructus Forsythiae, Herba Phyllanthi Urinariae, Flos Lonicerae and the Radix Aucklandiae.
5. according to Chinese medicine composition according to claim 4, it is characterized in that, the weight portion of each crude drug is: Radix Pulsatillae 60-90 part, Radix Puerariae 30-50 part, Fructus Mume 50-70 part, Radix Sanguisorbae 50-70 part, Fructus Forsythiae 50-60 part, Herba Phyllanthi Urinariae 40-50 part, Flos Lonicerae 30-40 part and Radix Aucklandiae 20-30 part.
6. according to Chinese medicine composition according to claim 5, it is characterized in that, the weight portion of each crude drug is: the Radix Pulsatillae 70 parts, Radix Puerariae 40 parts, Fructus Mume 60 parts, Radix Sanguisorbae 60 parts, Fructus Forsythiae 50 parts, Herba Phyllanthi Urinariae 40 parts, Flos Lonicerae 30 parts and the Radix Aucklandiae 20 parts.
7. prepare a method for claim 1 to 6 Chinese medicine composition described in any one, it is characterized in that, comprise the following steps:
(1) each crude drug is taken according to described proportioning;
(2) decoct after soaking in crude drug, decoction liquor filtered, filtrate is for subsequent use;
(3) add water in medicinal residues and decoct, filter, get filtrate;
(4) combining step (2) and step (3) filtrate and get final product.
8. in accordance with the method for claim 7, it is characterized in that: in step (2), decoct add the water soaking of 3-6 times of quality in crude drug after; Described soak time is 20-40 minute, is preferably 30 minutes; Described decocting time is 35-45 minute.
9. in accordance with the method for claim 7, it is characterized in that: the water adding 3-5 times of quality in step (3) in medicinal residues decocts; Described decocting time is 30-40 minute.
10. the purposes of the Chinese medicine composition of claim 1 to 6 described in any one in the medicine or reagent of preparation treatment chicken coccidiosis.
CN201410628044.9A 2014-11-10 2014-11-10 Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof Expired - Fee Related CN104398612B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410628044.9A CN104398612B (en) 2014-11-10 2014-11-10 Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410628044.9A CN104398612B (en) 2014-11-10 2014-11-10 Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof

Publications (2)

Publication Number Publication Date
CN104398612A true CN104398612A (en) 2015-03-11
CN104398612B CN104398612B (en) 2017-01-25

Family

ID=52636321

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410628044.9A Expired - Fee Related CN104398612B (en) 2014-11-10 2014-11-10 Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof

Country Status (1)

Country Link
CN (1) CN104398612B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105327168A (en) * 2015-11-07 2016-02-17 黑龙江省农业科学院畜牧研究所 Traditional Chinese medicine composition for preventing min pig acariasis and preparation method and application thereof
CN105327234A (en) * 2015-11-07 2016-02-17 黑龙江省农业科学院畜牧研究所 Traditional Chinese medicine composition for treating coccidiosis of Min pigs and preparation method and application thereof
CN107308235A (en) * 2017-06-27 2017-11-03 齐全农牧集团股份有限公司 A kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis
CN108310291A (en) * 2018-05-09 2018-07-24 东北农业大学 A kind of Chinese medicine composition and preparation method thereof for treating dove poultry louse disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100788A (en) * 2009-12-16 2011-06-22 青岛康地恩药业有限公司 Chinese medicinal preparation for preventing and treating chicken coccidiosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100788A (en) * 2009-12-16 2011-06-22 青岛康地恩药业有限公司 Chinese medicinal preparation for preventing and treating chicken coccidiosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
葛凯: "鸡球虫的分离鉴定及预防鸡球虫病中草药复方制剂的研究", 《中国优秀硕士学位论文全文数据库 农业科技辑》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105327168A (en) * 2015-11-07 2016-02-17 黑龙江省农业科学院畜牧研究所 Traditional Chinese medicine composition for preventing min pig acariasis and preparation method and application thereof
CN105327234A (en) * 2015-11-07 2016-02-17 黑龙江省农业科学院畜牧研究所 Traditional Chinese medicine composition for treating coccidiosis of Min pigs and preparation method and application thereof
CN107308235A (en) * 2017-06-27 2017-11-03 齐全农牧集团股份有限公司 A kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis
CN108310291A (en) * 2018-05-09 2018-07-24 东北农业大学 A kind of Chinese medicine composition and preparation method thereof for treating dove poultry louse disease

Also Published As

Publication number Publication date
CN104398612B (en) 2017-01-25

Similar Documents

Publication Publication Date Title
CN102078419B (en) Medicament for preventing and treating porcine reproductive and respiratory syndrome (PRRS) and preparation method thereof
CN104398612B (en) Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof
CN104256096A (en) Feed additive and feed for treating piglet diarrhea
CN101744924B (en) Multiple-effect Chinese herbal medicine compound of bacterial diseases of turbot
CN102961636B (en) Pure traditional Chinese medicine composition for treating poultry infectious bursal disease and preparation method thereof
CN104042983A (en) Traditional Chinese medicine for treating infantile diarrhea
CN1883610B (en) Chinese animal medicine for treating birds viral disease and method for preparing same
CN103860949A (en) Traditional Chinese medicine for treating children's diarrhea
CN104041668A (en) Dog food capable of preventing canine distemper and preparation method thereof
CN103285255B (en) Anti-coccidiosis pharmaceutical composition as well as preparation method and use thereof
CN102274303A (en) Traditional Chinese medicine extract compound injection for treating yellow-white dysentery of piglets and preparation method
CN103341005B (en) Traditional Chinese medicine preparation for treating chicken viral liver injury and preparation method thereof
CN104940404A (en) Preparation for preventing pullorum disease and preparation method
CN105250424A (en) Drug for preventing and treating pullorum disease and preparation method thereof
CN105395644A (en) Traditional Chinese medicinal composition for preventing and treating coccidiosis in chicken as well as preparation method and application of traditional Chinese medicinal composition
CN104857376A (en) Compound traditional Chinese medicine capable of promoting growing of broilers
CN104208524A (en) Medicine for treating piglet dysentery
CN107737195A (en) A kind of Chinese veterinary medicinal composition for treating swine fever and its preparation method and application
CN104274791A (en) Compound Chinese medicinal granule for treatment of chicken indigestion and preparation method thereof
CN107737286A (en) A kind of Chinese veterinary medicinal composition for preventing and treating swine enzootic pneumonia and its preparation method and application
CN104147399A (en) Pharmaceutical preparation for swine fever
CN104840591A (en) Traditional Chinese medicine composition with effect of preventing and treating Newcastle disease
CN104173491A (en) Traditional Chinese herbal medicine extract preparation for preventing and treating cow sunstroke and preparation method of traditional Chinese herbal medicine extract preparation
CN106389741A (en) Medicament for preventing and treating chicken coccidiosis
CN102309605A (en) Traditional Chinese medicine particulate agent for controlling infectious bursal disease and preparation method

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20170125

Termination date: 20171110