CN105327234A - Traditional Chinese medicine composition for treating coccidiosis of Min pigs and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating coccidiosis of Min pigs and preparation method and application thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a traditional Chinese medicine composition for treating coccidiosis of Min pigs and a preparation method and application thereof and belongs to the field of preparation of traditional Chinese medicines treating pig coccidiosis. The traditional Chinese medicine composition for treating the coccidiosis of the pigs includes caesalpinia sepiaria, rhizoma bletillae, hiraute shiny bugleweed herb, herba ecliptae, kaempferia galanga and hippophae rhamnoides. On the basis of the traditional Chinese medicine composition, polygonum multiflorum, Chinese soapberry fruits and polygonatum sibiricum are added, the traditional Chinese medicine composition has the obvious synergistic effect and can remarkably improve the cure rate of the pig coccidiosis, and the cure rate is as high as 98%. The pig coccidiosis treating effect of the traditional Chinese medicine composition is exact, and the traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, is good in safety and can be applied to preparation of the medicines for treating the pig coccidiosis. The raw materials of the traditional Chinese medicine composition are wide in source, the preparation method is simple, and the traditional Chinese medicine composition is suitable for industrial production.
Description
Technical field
The present invention relates to the Chinese medicine composition for the treatment of pig coccidiosis, also relate to the preparation method and application of described Chinese medicine composition, belong to the Chinese drug preparation field for the treatment of pig coccidiosis.
Background technology
Pig coccidiosis (SwineCoccidiosis) is more common in piglet, be by Amy otology Eimeria (Eimeria) and etc. spore belong to the coccidiosis of (Isospora) and parasitize swine intestinal epithelium cells and the parasitic disease that causes, the digestive tract disease that piglet is serious can be caused.The kind of pig coccidiosis is a lot, but to piglet pathogenicity the strongest be Isospora suis.The infection of Isospora suis with the diarrhoea of water sample or fat sample for feature, Excreta stench, yellowish or white, sick pig performance is weak, dehydration, hypoevolutism, even dead.In recent years, pig coccidium infection ubiquity, in addition concurrent bacterial, virus or other parasitic disease, mortality rate is quite high, in worldwide distribution, causes serious economic loss to pig industry.
Therefore, develop a kind of Chinese medicine composition effectively can treating pig coccidiosis newly have great importance and be worth.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for the treatment of pig coccidiosis, and the cure rate of this Chinese medicine composition to pig coccidiosis is high;
Another technical problem to be solved by this invention is to provide a kind of preparation method of described Chinese medicine composition and the application in the medicine of preparation treatment pig coccidiosis thereof.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
First the present invention discloses a kind of Chinese medicine composition for the treatment of pig coccidiosis, comprises following component: Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae and Fructus Hippophae.
The weight portion of each component is: Semen Caesalpiniae 30-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 30-50 part, Herba Lycopi 20-30 part, Herba Ecliptae 10-25 part, Rhizoma Kaempferiae 5-20 part and Fructus Hippophae 5-20 part; Preferably, the weight portion of each component is: Semen Caesalpiniae 55 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 42 parts, Herba Lycopi 30 parts, Herba Ecliptae 23 parts, Rhizoma Kaempferiae 15 parts and Fructus Hippophae 15 parts.
Semen Caesalpiniae is the seed of pulse family Caesalpinia Semen Caesalpiniae CaesalpinisscpiariaRoxb..Nature and flavor are pungent, temperature.Seed is poisonous.Function cures mainly: seed: dysentery relieving, anthelmintic.
Pseudobulbus Bletillae (Rhizoma Bletillae) is the dry tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletillastriata (Thunb.) Reichb.f..Nature and flavor are bitter, sweet, puckery, are slightly cold.Return lung, liver, stomach warp.Function cures mainly: astringing to arrest bleeding, detumescence and promoting granulation.
Herba Lycopi is the dry aerial parts of labiate hair leaf lycopus lucidus LycopuslucidusTurcz.var.hirtusRegel.Nature and flavor are bitter, pungent, tepor.Return liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, line water detumescence.
Herba Ecliptae is the dry aerial parts of feverfew Eclipta prostrata EcliptaprostrataL..Nature and flavor are sweet, sour, cold.Return kidney, Liver Channel.Function cures mainly: nourishing the liver and kidney, cooling blood for hemostasis.
Rhizoma Kaempferiae is the dry rhizome of zingiberaceous plant Rhizoma Kaempferiae KaempferiagalangaL..Nature and flavor are pungent, temperature.Return stomach warp.Function cures mainly: circulation of qi promoting warming middle-JIAO, helps digestion, pain relieving.
Fructus Hippophae is the dry mature fruit of Elaeangnaceae hippophae plant Fructus Hippophae HippophaerhamnoidesL..Nature and flavor are sour, puckery, temperature.Function cures mainly: eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis.
Chinese medicine composition prepared by Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae and Fructus Hippophae compatibility is had effect of definite treatment pig coccidiosis by the present invention.State effect when Chinese medicine composition basis adding following crude drug with better heat-clearing and toxic substances removing, invigorating the spleen to arrest diarrhea on the invention: Radix Polygoni Multiflori, Fructus Sapindi Mukouossi and Rhizoma Polygonati; The weight portion of each component is, Radix Polygoni Multiflori 20-40 part, Fructus Sapindi Mukouossi 20-30 part and Rhizoma Polygonati 10-25 part; Preferably, the weight portion of each component is: Radix Polygoni Multiflori 35 parts, Fructus Sapindi Mukouossi 30 parts and Rhizoma Polygonati 20 parts.
Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb PolygonummultiflorumThunb..Nature and flavor are bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Function cures mainly: removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.
Fructus Sapindi Mukouossi is the fruit of Sapindaceae soapberry Fructus Sapindi Mukouossi SapindusmukorossiGaertn..Nature and flavor are bitter, micro-pungent, cold.Slightly poisonous.Function cures mainly: clearing heat and dispersing phlegm, sore-throat relieving antidiarrheal.
Rhizoma Polygonati is the dry rhizome of liliaceous plant P. kingianum PolygonatumkingianumColl.etHemsl., Rhizoma Polygonati PolygonatumsibiricumRed. or Polygonatum cyrtonema Hua PolygonatumcyrtonemaHua.Nature and flavor are sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
The invention also discloses a kind of preparation method of described Chinese medicine composition, comprise the following steps: (1) takes each crude drug according to described ratio; (2) by each crude drug extracting in water respectively, merge extractive liquid, filters, concentrated, to obtain final product.
Wherein, step (2) described extracting in water is count in mass ratio, makes solid-liquid ratio be 1:5-20; The temperature extracted is 80-100 DEG C; The time of extracting is 0.5-2 hour; The number of times extracted is 1-3 time.The present invention is not particularly limited described concentrating, and can adjust according to actual needs, preferably filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C) to concentration ratio.
The another kind of preparation method of Chinese medicine composition of the present invention, comprising: after being taken by described weight by each crude drug, pulverizes, sieve (such as, can be 80-300 mesh sieve), and mixing, to obtain final product.
Chinese medicine composition of the present invention can be applied to the medicine of preparation treatment pig coccidiosis.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., be prepared into the suitable oral formulations of any one with the method for Chinese medicinal of routine, described oral formulations can be powder, granule, tablet, oral liquid etc.Pharmaceutically acceptable adjuvant of the present invention includes but not limited to following: diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.; Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.; Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.; Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.; Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods; Correctives: sucrose, monosaccharide, aromatic etc.; Antiseptic: benzoic acid, sorbic acid etc.
The experimental result for the treatment of pig coccidiosis shows, Chinese medicine composition of the present invention has definite therapeutic effect to pig coccidiosis.The Chinese medicine composition prepared by Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae and Fructus Hippophae is 82% to the cure rate of coccidiasis in piglets on some farms.And on Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae and Fructus Hippophae basis, add Radix Polygoni Multiflori, Fructus Sapindi Mukouossi and Rhizoma Polygonati, the cure rate of pig coccidiosis can be significantly improved, 98% is reached to the cure rate of ill piglet.These results suggest that Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae, Fructus Hippophae and Radix Polygoni Multiflori, to there is between Fructus Sapindi Mukouossi and Rhizoma Polygonati obvious synergistic function.
Chinese medicine composition of the present invention is mixed in pig normal feedstuff according to the mass ratio of 0.2%-1%, conventionally feeds, and also can suitably adjust using dosage and service time according to the state of an illness, generally be used in conjunction 5-7 day, can fully recover.The pig coccidiosis caused by coccidiosis that pig coccidiosis of the present invention comprises Amy otology Eimeria and waits spore to belong to.
Chinese medicine composition of the present invention is applicable to the pig of different cultivars, is preferably people pig.People pig is the local varieties pig of China, affiliated regnum animale, and pig subfamily, is distributed in the ground such as Heilungkiang, Jilin, Liaoning, Hebei and Inner Mongolia, has build compared with features such as large, reproductive capacity is strong, body fat is many, cold-resistant, crude feed tolerances.
Technical solution of the present invention compared with prior art, has following beneficial effect:
The determined curative effect of traditional Chinese medicine composition for treating pig coccidiosis of the present invention, cure rate is up to 98%.And Chinese medicine composition of the present invention is nontoxic, has no adverse reaction after using, safety is good.In addition, each crude drug wide material sources of the present invention, preparation method is simple, is suitable for suitability for industrialized production, has applications well prospect.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.It should be understood that described embodiment is only exemplary, any restriction is not formed to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments or replacement all fall into protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 30, Pseudobulbus Bletillae (Rhizoma Bletillae) 30, Herba Lycopi 20, Herba Ecliptae 10, Rhizoma Kaempferiae 5 and Fructus Hippophae 5 according to following ratio;
By each crude drug extracting in water respectively, count in mass ratio, make solid-liquid ratio be 1:5, the temperature of extraction is 80 DEG C; The time of extracting is 0.5 hour; The number of times extracted is 1 time; Merge each extracting solution, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C), to obtain final product.
The preparation of embodiment 2 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 60, Pseudobulbus Bletillae (Rhizoma Bletillae) 50, Herba Lycopi 30, Herba Ecliptae 25, Rhizoma Kaempferiae 20 and Fructus Hippophae 20 according to following ratio;
By each crude drug extracting in water respectively, count in mass ratio, make solid-liquid ratio be 1:20, the temperature of extraction is 100 DEG C; The time of extracting is 2 hours; The number of times extracted is 3 times; Merge each extracting solution, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C), to obtain final product.
The preparation of embodiment 3 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 55, Pseudobulbus Bletillae (Rhizoma Bletillae) 42, Herba Lycopi 30, Herba Ecliptae 23, Rhizoma Kaempferiae 15 and Fructus Hippophae 15 according to following ratio.
By each crude drug extracting in water respectively, count in mass ratio, make solid-liquid ratio be 1:10, the temperature of extraction is 90 DEG C; The time of extracting is 1 hour; The number of times extracted is 2 times; Merge each extracting solution, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C), to obtain final product.
The preparation of embodiment 4 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 30, Pseudobulbus Bletillae (Rhizoma Bletillae) 30, Herba Lycopi 20, Herba Ecliptae 10, Rhizoma Kaempferiae 5, Fructus Hippophae 5, Radix Polygoni Multiflori 20, Fructus Sapindi Mukouossi 20 and Rhizoma Polygonati 10 according to following ratio.
By each crude drug extracting in water respectively, count in mass ratio, make solid-liquid ratio be 1:5, the temperature of extraction is 80 DEG C; The time of extracting is 0.5 hour; The number of times extracted is 1 time; Merge extractive liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C), to obtain final product.
The preparation of embodiment 5 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 60, Pseudobulbus Bletillae (Rhizoma Bletillae) 50, Herba Lycopi 30, Herba Ecliptae 25, Rhizoma Kaempferiae 20, Fructus Hippophae 20, Radix Polygoni Multiflori 40, Fructus Sapindi Mukouossi 30 and Rhizoma Polygonati 25 according to following ratio.
By each crude drug extracting in water respectively, count in mass ratio, make solid-liquid ratio be 1:20, the temperature of extraction is 100 DEG C; The time of extracting is 2 hours; The number of times extracted is 3 times; Merge extractive liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C), to obtain final product.
The preparation of embodiment 6 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 55, Pseudobulbus Bletillae (Rhizoma Bletillae) 42, Herba Lycopi 30, Herba Ecliptae 23, Rhizoma Kaempferiae 15, Fructus Hippophae 15, Radix Polygoni Multiflori 35, Fructus Sapindi Mukouossi 30 and Rhizoma Polygonati 20 according to following ratio.
By each crude drug extracting in water respectively, count in mass ratio, make solid-liquid ratio be 1:10, the temperature of extraction is 90 DEG C; The time of extracting is 1 hour; The number of times extracted is 2 times; Merge each extracting solution, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C), to obtain final product.
The preparation of embodiment 7 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 55, Pseudobulbus Bletillae (Rhizoma Bletillae) 42, Herba Lycopi 30, Herba Ecliptae 23, Rhizoma Kaempferiae 15, Fructus Hippophae 15, Radix Polygoni Multiflori 35, Fructus Sapindi Mukouossi 30 and Rhizoma Polygonati 20 according to following ratio.
Pulverized by each crude drug, cross 200 mesh sieves, mixing, to obtain final product.
The preparation of embodiment 8 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 55, Pseudobulbus Bletillae (Rhizoma Bletillae) 42, Herba Lycopi 30, Herba Ecliptae 23, Rhizoma Kaempferiae 15 and Fructus Hippophae 15 according to following ratio.
Pulverized by each crude drug, cross 300 mesh sieves, mixing, to obtain final product.
The preparation of embodiment 9 Chinese medicine composition
Each crude drug (g) is taken: Semen Caesalpiniae 30, Pseudobulbus Bletillae (Rhizoma Bletillae) 30, Herba Lycopi 20, Herba Ecliptae 10, Rhizoma Kaempferiae 5, Fructus Hippophae 5, Radix Polygoni Multiflori 20, Fructus Sapindi Mukouossi 20 and Rhizoma Polygonati 15 according to following ratio.
Pulverized by each crude drug, cross 80 mesh sieves, mixing, to obtain final product.
The preparation of embodiment 10 tablet
Compositions 15 grams prepared by Example 7 adds starch 15 grams, mix homogeneously, then mixs homogeneously with 30 grams, dextrin, adds ethanol (50%) soft material processed in right amount; Granulated by 16 order nylon mesh, 60 DEG C of dryings, dry granular, after 16 mesh sieve granulate, adds magnesium stearate 5 grams, tabletting after mix homogeneously.
The Experiment on therapy of experimental example 1 pig coccidiosis
1, experimental technique
To be diagnosed as the people porkling pig of 150 14 ages in days of the coccidiosis caused by Isospora suis, cardinal symptom is diarrhoea, and feces is water sample or pasty state, and displaing yellow is to white, and be brown once in a while due to occult blood, stool examination finds egg capsule.Be divided into 3 groups at random, blank group need not any medicine; Test the Chinese medicine composition that 1,2 group is taken embodiment 3 and embodiment 6 preparation respectively, the mass ratio according to 0.5% is mixed in pig feed feeds, and routine is fed, and is used in conjunction 5, adds up the therapeutic effect of each group.
2, experimental result
The therapeutic effect of each group is in table 1.
The statistical result of table 1 therapeutic effect
Result shows, after taking the embodiment of the present invention 3 Chinese medicine composition, the cure rate of affected pig coccidiosis piglet is 70%.Take the embodiment of the present invention 6 Chinese medicine composition after 3 days, most of piglet stops diarrhoea, and the cure rate being used in conjunction ill piglet on the 5th reaches 98%.
These results suggest that, Radix Polygoni Multiflori, Fructus Sapindi Mukouossi and Rhizoma Polygonati are added in Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae and Fructus Hippophae basis, pig coccidiosis cure rate can be significantly improved, prove Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae, Fructus Hippophae and Radix Polygoni Multiflori, there is between Fructus Sapindi Mukouossi and Rhizoma Polygonati obvious synergistic function.
Claims (10)
1. treat a Chinese medicine composition for pig coccidiosis, it is characterized in that, comprise following component: Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae and Fructus Hippophae.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each component is: Semen Caesalpiniae 30-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 30-50 part, Herba Lycopi 20-30 part, Herba Ecliptae 10-25 part, Rhizoma Kaempferiae 5-20 part and Fructus Hippophae 5-20 part.
3. according to the Chinese medicine composition described in claim 1 or 2, it is characterized in that, the weight portion of each component is: Semen Caesalpiniae 55 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 42 parts, Herba Lycopi 30 parts, Herba Ecliptae 23 parts, Rhizoma Kaempferiae 15 parts and Fructus Hippophae 15 parts.
4. treat a Chinese medicine composition for pig coccidiosis, it is characterized in that, comprise following component: Semen Caesalpiniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lycopi, Herba Ecliptae, Rhizoma Kaempferiae, Fructus Hippophae, Radix Polygoni Multiflori, Fructus Sapindi Mukouossi and Rhizoma Polygonati.
5. according to Chinese medicine composition according to claim 4, it is characterized in that, the weight portion of each component is: Semen Caesalpiniae 30-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 30-50 part, Herba Lycopi 20-30 part, Herba Ecliptae 10-25 part, Rhizoma Kaempferiae 5-20 part, Fructus Hippophae 5-20 part, Radix Polygoni Multiflori 20-40 part, Fructus Sapindi Mukouossi 20-30 part and Rhizoma Polygonati 10-25 part.
6. according to the Chinese medicine composition described in claim 4 or 5, it is characterized in that, the weight portion of each component is: Semen Caesalpiniae 55 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 42 parts, Herba Lycopi 30 parts, Herba Ecliptae 23 parts, Rhizoma Kaempferiae 15 parts, Fructus Hippophae 15 parts, Radix Polygoni Multiflori 35 parts, Fructus Sapindi Mukouossi 30 parts and Rhizoma Polygonati 20 parts.
7. a preparation method for claim 1 to 6 Chinese medicine composition described in any one, is characterized in that, comprise the following steps: (1) takes each crude drug according to described ratio; (2) by each crude drug extracting in water respectively, merge extractive liquid, filters, concentrated, to obtain final product;
Preferably, step (2) described extracting in water is count in mass ratio, makes solid-liquid ratio be 1:5-20; The temperature extracted is 80-100 DEG C; The time of extracting is 0.5-2 hour; The number of times extracted is 1-3 time.
8. a preparation method for claim 1 to 6 Chinese medicine composition described in any one, is characterized in that, comprise the following steps: take each crude drug according to described ratio, pulverizes, sieves, and mixing, to obtain final product;
Preferably, wherein saidly to sieve as crossing 80-300 mesh sieve.
9. the application of the Chinese medicine composition of claim 1 to 6 described in any one in the medicine of preparation treatment pig coccidiosis.
10. according to the Chinese medicine composition described in claim 1 or 4, it is characterized in that, described pig comprises: people pig.
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| CN103432441A (en) * | 2013-08-10 | 2013-12-11 | 安徽快康生物科技有限公司 | Traditional Chinese medicine composition for treating coccidiosis in chicken |
| CN104398612A (en) * | 2014-11-10 | 2015-03-11 | 东北农业大学 | Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof |
| CN104958397A (en) * | 2015-05-26 | 2015-10-07 | 安徽恒源药业有限公司 | Traditional Chinese medicine composition for treating poultry small intestine coccidiosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103432441A (en) * | 2013-08-10 | 2013-12-11 | 安徽快康生物科技有限公司 | Traditional Chinese medicine composition for treating coccidiosis in chicken |
| CN104398612A (en) * | 2014-11-10 | 2015-03-11 | 东北农业大学 | Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof |
| CN104958397A (en) * | 2015-05-26 | 2015-10-07 | 安徽恒源药业有限公司 | Traditional Chinese medicine composition for treating poultry small intestine coccidiosis |
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